CN107050406A - Child's sterilizing liquid and preparation method thereof - Google Patents
Child's sterilizing liquid and preparation method thereof Download PDFInfo
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- CN107050406A CN107050406A CN201710078739.8A CN201710078739A CN107050406A CN 107050406 A CN107050406 A CN 107050406A CN 201710078739 A CN201710078739 A CN 201710078739A CN 107050406 A CN107050406 A CN 107050406A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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Abstract
Child's sterilizing liquid and preparation method thereof, it belongs to infant health field of medical technology.Currently marketed child's sterilizing liquid, containing alcohol or Western medicine antiseptic, perfume ingredient, excitant is stronger when using, and is not appropriate for child and is commonly used.Child of the present invention is mainly made up with sterilizing liquid of plant composite extract, glycerine, polysorbate60, preservative, deionized water, its parts by weight be respectively 10~20 parts Chinese medicine composite extract, 5~10 parts of glycerine, 1~5 part of Tween 80,0.5~3 part of preservative, 80~100 parts of deionized water, described Chinese medicine composite extract is mainly made up of cannalike dona rhizome, greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf, mile swertia herb, henry hemsleya root, selfheal, tea rose, small adder tongue herb, gray gum, emblic leafflower bark, folium artemisiae argyi, aloe, ginger.The present invention has complementary advantages plurality of raw materials mix and match, scientific composition, each raw material, and sterilizing bactericidal effect is good.
Description
Technical field
The invention belongs to infant health field of medical technology；Specifically related to a kind of child's sterilizing liquid and its preparation side
Method.
Background technology
During child's outdoor activity, winter cold is dried, and the moisture loss in child's skin is more, smegma compared with
It is few, skin easily occur it is dry and cracked itch, summer weather moistening, but because mosquito is more, easily causes and bite, and high humidity
When bacterium liquid easily grow.Harmful substance is readily adsorbed on skin.And child is in delicate health bears a pretty, delicate skin, organ function
With immunologic function all prematurities, if there is bacterial invasion to cause infection.Wherein with staphylococcus aureus, enteropathogenic E. Coli
Property diarrhoea and salmonella at most, infection is popular, once occurring, and propagates quickly.So the health of child's skin and protection are extremely closed
It is important.
Currently marketed child's sterilizing liquid, typically contains a large amount of alcohol or Western medicine antiseptic composition, also containing perfume (or spice)
The compositions such as essence, excitant is stronger when using, and is not appropriate for child and is commonly used.
The content of the invention
It is an object of the present invention to provide it is a kind of it is gentle, with skin care and bactericidal effect and child's sterilizing liquid for depositing
And preparation method thereof.
The present invention is achieved through the following technical solutions：
A kind of child's sterilizing liquid, described child is with sterilizing liquid mainly by plant composite extract, sweet
Oil, polysorbate60, preservative, deionized water are made, its parts by weight be respectively 10~20 parts Chinese medicine composite extract, 5~10
The glycerine of part, 1~5 part of Tween 80,0.5~3 part of preservative, 80~100 parts of deionized water, described Chinese medicine is compound to be carried
If taking owner by cannalike dona rhizome, greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf, mile swertia herb, henry hemsleya root, selfheal, tea rose, small
Adder tongue herb, gray gum, emblic leafflower bark, folium artemisiae argyi, aloe, ginger are made.
The parts by weight of cannalike dona rhizome are in child's sterilizing liquid of the present invention, described plant composite extract
7~15 parts, the parts by weight of greater celandine be 15~20 parts, the parts by weight of the balsarm of Peru be 15~20 parts, the weight of pinkflower ecdysanthera root and leaf
Amount number is 10~15 parts, the parts by weight of mile swertia herb are 7~10 parts, the parts by weight of henry hemsleya root are 10~20 parts, selfheal
Parts by weight be 10~15 parts, the parts by weight of tea rose be 5~10 parts, the parts by weight of small adder tongue herb be 7~15 parts,
The parts by weight of gray gum are 10~20 parts, the parts by weight of emblic leafflower bark are 5~10 parts, the parts by weight of folium artemisiae argyi are 20~30
Part, the parts by weight of aloe be 20~30 parts, the parts by weight of ginger be 10~20 parts.
Child's sterilizing liquid of the present invention, described preservative is the mixing of potassium sorbate and western pyrrole chloramines
Thing, the wherein mass ratio of potassium sorbate and western pyrrole chloramines are 1:1.
Plant composite extract in child's sterilizing liquid of the present invention, described child's sterilizing liquid
Parts by weight are 10 parts, and the parts by weight of glycerine are 5 parts, and the parts by weight of Tween 80 are 1 part, and the parts by weight of preservative are
0.5 part, the parts by weight of deionized water are 80 parts.
Plant composite extract in child's sterilizing liquid of the present invention, described child's sterilizing liquid
Parts by weight are 20 parts, and the parts by weight of glycerine are 10 parts, and the parts by weight of Tween 80 are 5 parts, and the parts by weight of preservative are 3
Part, the parts by weight of deionized water are 100 parts.
The preparation method of child's sterilizing liquid of the present invention, comprises the following steps：
The preparation of step 1, plant composite extract；
Step 2, the plant composite extract that 10~20 parts are weighed according to parts by weight respectively, 5~10 parts of glycerine, will claim
Measured plant composite extract is slowly added in glycerine, the first mixed liquor is obtained after stirring stand-by；
Step 3, the Tween 80 that weighs according to parts by weight 1~5 part respectively, 0.5~3 part of preservative, 80~100 parts
Deionized water, load weighted medicine is poured into deionized water, the second mixed liquor is obtained after stirring stand-by；
Step 4, by the first mixed liquor made from step 2, second is slowly added to made from step 3 under conditions of stirring and is mixed
Close in liquid, after stirring, obtain described child's sterilizing liquid.
The preparation method of child's sterilizing liquid of the present invention, the system of the plant composite extract described in step 1
It is standby, comprise the following steps：
Step A, the cannalike dona rhizome for weighing according to parts by weight certain mass respectively, greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf,
Mile swertia herb, henry hemsleya root, selfheal, tea rose, small adder tongue herb, gray gum, emblic leafflower bark, folium artemisiae argyi, aloe, ginger, will be weighed
Good Chinese medicine is respectively placed in 5~20min of crushing in Study on Supermicro-pulverization of Traditional Chinese Drugs machine, crushes acc power 1.8kw, pulverizer rotating speed
22000rad/min, 1~4kg/h of crushing quantity, cross 100 mesh sieves standby after crushing；
Weighed after step B, the plant powder for crushing step A are well mixed, institute is poured into the plant powder mixed
Claim the alcoholic solution of 10~20 times of quality, carry out alcoholic extract under the cooperation of ultrasonic wave, interruption ultrasound, per hour ultrasound 5~
15min, 1000~5000Hz of supersonic frequency, 5~10h of alcoholic extract time, take supernatant A stand-by, and remaining filter residue continues to press
Soaked once with alcoholic solution according to the above method, the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B pass through vacuum distillation recovered alcohol, control 55~65 DEG C of temperature, pressure
- 0.1MPa, obtains plant compound collecting concentrate by force；
Step D, the plant compound collecting concentrate that step C is obtained is freeze-dried, -60 DEG C of cryogenic temperature, freezing
Pressure 30Pa, 10~20h of cooling time, obtains plant composite extract.The purpose of freeze-drying is to obtain pure vegetable jelly
Dry composite extract, it is to avoid the residual of alcohol in step B alcoholic extracts.
Stirring condition in the preparation method of child's sterilizing liquid of the present invention, step 2 is speed of agitator 100
~200rad/min, 5~10min of mixing time.
Stirring condition in the preparation method of child's sterilizing liquid of the present invention, step 3 is speed of agitator 100
~200rad/min, 2~5min of mixing time.
Stirring condition in the preparation method of child's sterilizing liquid of the present invention, step 4 is speed of agitator 100
~200rad/min, 10~30min of mixing time.
Child of the present invention is with the rhizome that the cannalike dona rhizome in sterilizing liquid is Marantaceae plant cannalike dona rhizome, with clear
The effect of thermal detoxification, relieving cough and relieving asthma, anti-inflammation and sterilization.Pulmonary tuberculosis is controlled, tracheobronchitis, asthma, hyperpyrexia prevents children's measles
Merge pneumonia, cold, fever, various dermopathic effects.Greater celandine can be used in gastritis, and gastric ulcer is suffered from abdominal pain, enteritis, dysentery,
Jaundice, chronic bronchitis, pertussis；Paddy-field dermatitis is controlled in external application, is prevented and is treated insect-bite.The balsarm of Peru is dense oily
Body, brown redness of the skin or complexion or even crineous, thin layer are then transparent, in rufous, non-adhesiveness and lead a property, there is disinfective action, oleoresin portion
Divide energy promotion organization reparation, the effect that resin also has localised protection and reduced inflammation, thus can be used for skin, the chronic inflammation of mucous membrane
Disease；And ulcer, the healing of wound can be promoted.The fungal infection of some skins can also be treated.Pinkflower ecdysanthera root and leaf can anti-inflammatory, sterilization,
Go rotten dirty.Control stomatitis, laryngitis, gingivitis, boil ulcer.Solution big tea medicine poison, wood eat poison, crotons poison.Mile swertia herb is Gentianaceae
The herb of plant North Guangdong Swertia patens, is distributed in the ground such as Yunnan, Guangdong, the effects such as having clearing heat and detoxicating, relaxing liver and strengthening stomach, anti-inflammation and sterilization.
Henry hemsleya root can be clearing heat and detoxicating；Analgesic.Main bacillary dysentery；Enteritis；Gastritis；Sphagitis；Parotitis；Periodontitis；Epidemic conjunctivitis；Tonsillotome
It is scorching；Hyperpyrexia；Urinary tract infections.Selfheal is the fruit ear of labiate selfheal or long hat selfheal, and clearing heat-fire, improving eyesight dissipates
Knot detumescence.Tea rose is the rose family, is used as medicine with root, leaf, insect gall,：Regulating the qi flowing in the channels and blood, stop dysentery, cough-relieving, Dingchuan, anti-inflammatory, sterilization.
Dysentery is cured mainly, children's hernia, asthma is suffered from diarrhoea,；Sore, carbuncle, furuncle are controlled in external application.Small adder tongue herb is used as medicine with root, anti-inflammatory, sterilization, diuresis,
Desinsection.Cure mainly amoebic dysentery, laryngitis, athlete's foot, poor appetite, abdominal distension.Gray gum being capable of anti-inflammation and sterilization, expelling phlegm and arresting coughing, receipts
Hold back desinsection.For preventing influenza, Japanese Type-B encephalitis.Prevent and treat malaria, enteritis, diarrhoea, dysentery, exanthemv, carbuncle
Sore is red and swollen, erysipelas, mastitis, trauma infection contamination, psoriasis, neurodermatitis.Leptospirosis can be also controlled, tracheitis is coughed, can
Smoked mosquito.Contain Lupeol, leucodelphindin in emblic leafflower bark.In withe containing corilagin, glucogallin,
Chebulagic acid, chebulinic acid, 3,6- digalloylglucoses, benzoaric acid, to staphylococcus aureus, hemolytic chain
Coccus, Pseudomonas aeruginosa, bacterium flexneri, proteus, Escherichia coli have vitro antibacterial activity.Folium artemisiae argyi ends for feverfew
Dried leaf.Spring, Xia Erji, are plucked when Hua Weikai, leafiness, are dried or are dried in the shade.There is rationale blood, by cold-dampness；Wen Jing, hemostasis
Effect.Aloe is a kind of Liliaceae herbaceous plant, originates in Africa, and according to wild aloe kind kind more than 300 of textual criticism, it is for many years
Raw Liliaceae meat herbaceous plant.Extremely have containing abundant polysaccharide, protein, amino acid, vitamin, organized enzyme and to human body
The trace element of benefit, sterilization, anti-inflammatory is immunized, removing toxic substances.Ginger is pungent, tepor, return lung taste warp, inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting,
Warm lung cough-relieving, solving toxin of fish and crab, antidote poison.
Child of the present invention with the significant cannalike dona rhizome of the selected effect of sterilizing liquid, greater celandine, pinkflower ecdysanthera root and leaf, green grass or young crops
The high-quality genunie medicinal materials compatibility such as Ye Dan, henry hemsleya root, selfheal, tea rose, small adder tongue herb, gray gum, folium artemisiae argyi balsarm of Peru, oil
Mandarin orange wood skin, using the warm-natured characteristic of ginger, adjusts cold in medicinal material, to be adapted to the use of child, is equipped with moisturizing, the profit of aloe
Effect of skin so that the present invention is not only the effect killed virus, sterilized, and also with certain moisturizing, skin care, prevents bite by mosquitos
Effect.Elite active component is taken out using superfine communication technique combination alcoholic extract, makes plant essence and Peru fragrant to greatest extent
Glue, emblic leafflower bark composition are combined together, and to kill various bacteriums, removing toxicity for detumescence, hemostasis and pain-relieving is effectively solved multipath
The problem of skin surface.
Child of the present invention effectively kills the various bacteriums between palm and webs, such as gas with sterilization liquid energy
It is monad, staphylococcus, corynebacteria, Klebsiella, acinetobacter haemolyticus, lung inflammatory streptococcus, Escherichia coli, pathogenic
Saccharomycete, and use and easy to carry, both hands can be cleaned whenever and wherever possible, and the Disinfection Effect duration is long, sustainable 4-6
Hour, effectively reduce the cross-infection of public place.
Child of the present invention is with sterilizing liquid by plurality of raw materials mix and match, and scientific composition, each raw material advantage is mutual
Mend, using its mutual collaboration or resistant function, add moisturizing skin care ingredient, such as glycerine, aloe are reduced to skin
Stimulation, nourishes rough skin, keep hand moisten, it is nontoxic to normal skin non-stimulated, add the balsarm of Peru, the oil of Anti-mosquito disinsectization
The extract of mandarin orange wood skin, and ginger is added to improve the property of medicine gently, it is safe and efficient.
Embodiment
Embodiment one：
A kind of child's sterilizing liquid, described child is with sterilizing liquid mainly by plant composite extract, sweet
Oil, polysorbate60, preservative, deionized water are made, its parts by weight be respectively 10 parts Chinese medicine composite extract, 5 parts of glycerine,
1 part of Tween 80,0.5 part of preservative, 80 parts of deionized water, described Chinese medicine composite extract mainly by cannalike dona rhizome,
Greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf, mile swertia herb, henry hemsleya root, selfheal, tea rose, small adder tongue herb, gray gum, phyllanthus emblica wood
Skin, folium artemisiae argyi, aloe, ginger are made.
The parts by weight of cannalike dona rhizome in child's sterilizing liquid described in present embodiment, described plant composite extract
Number is 7 parts, the parts by weight of greater celandine are 15 parts, the parts by weight of the balsarm of Peru are 15 parts, the parts by weight of pinkflower ecdysanthera root and leaf are
10 parts, the parts by weight of mile swertia herb be 7 parts, the parts by weight of henry hemsleya root be 10 parts, the parts by weight of selfheal be 10 parts, perfume
The parts by weight of Chinese rose are 5 parts, the parts by weight of small adder tongue herb are 7 parts, the parts by weight of gray gum are 10 parts, emblic leafflower bark
Parts by weight are 5 parts, the parts by weight of folium artemisiae argyi are 20 parts, the parts by weight of aloe are 20 parts, the parts by weight of ginger are 10 parts.
Child's sterilizing liquid described in present embodiment, described preservative is the mixed of potassium sorbate and western pyrrole chloramines
Compound, the wherein mass ratio of potassium sorbate and western pyrrole chloramines are 1:1.
Sterilization experiment is carried out with sterilizing liquid using child made from present embodiment, experimental strain is golden yellow grape
Coccus, Candida albicans, pseudomonas aeruginosa, Escherichia coli, the control group of bacteriostatic experiment use the tincture of iodine of 0.5% concentration, bacterium
It is beef-protein medium to plant culture medium.
Specific experiment step is：
(1) bacterium solution is prepared, above-mentioned four groups of strains are inoculated on beef-protein medium respectively, is cultivated at 37 DEG C
24h, with a little thalline of oese picking in the test tube equipped with sterile saline, concussion is uniform, and bacteria suspension is made；
(2) described child's sterilizing liquid and each 20ml of the tincture of iodine is taken respectively, is respectively placed in sterile petri dish, it is standby
With；
(3) the bacteria suspension 0.1ml being made is respectively placed in test cultures ware, is well mixed, is respectively labeled as thimerosal
Group and tincture of iodine group, test result are as shown in table 1：It can be derived that present embodiment has compared to the general tincture of iodine from table 1 more preferable
Bactericidal effect, and being capable of fungistatic effect for a long time.
The bactericidal effect table of comparisons of table 1
Embodiment two：
The preparation method of child's sterilizing liquid according to embodiment one, comprises the following steps：
The preparation of step 1, plant composite extract；
Step 2, the plant composite extract that 10 parts are weighed according to parts by weight respectively, 5 parts of glycerine, plant load weighted
Thing composite extract is slowly added in glycerine, the first mixed liquor is obtained after stirring stand-by；
Step 3, the Tween 80,0.5 part of preservative, 80 parts of deionized water for weighing according to parts by weight 1 part respectively, will
Load weighted medicine is poured into deionized water, the second mixed liquor is obtained after stirring stand-by；
Step 4, by the first mixed liquor made from step 2, second is slowly added to made from step 3 under conditions of stirring and is mixed
Close in liquid, after stirring, obtain described child's sterilizing liquid.
The preparation method of child's sterilizing liquid described in present embodiment, the plant composite extract described in step 1
Preparation, comprise the following steps：
Step A, the cannalike dona rhizome for weighing according to parts by weight certain mass respectively, greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf,
Mile swertia herb, henry hemsleya root, selfheal, tea rose, small adder tongue herb, gray gum, emblic leafflower bark, folium artemisiae argyi, aloe, ginger, will be weighed
Good Chinese medicine, which is respectively placed in Study on Supermicro-pulverization of Traditional Chinese Drugs machine, crushes 10min, crushes acc power 1.8kw, pulverizer rotating speed 22000rad/
Min, 1~4kg/h of crushing quantity, cross 100 mesh sieves standby after crushing；
Weighed after step B, the plant powder for crushing step A are well mixed, institute is poured into the plant powder mixed
Claim the alcoholic solution of 10 times of quality, alcoholic extract is carried out under the cooperation of ultrasonic wave, interruption is ultrasonic, per hour ultrasound 5min, surpasses
Acoustic frequency 1000Hz, alcoholic extract time 10h, takes supernatant A stand-by, and remaining filter residue continues molten with alcohol according to the method described above
Immersion is steeped once, and the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B by vacuum distillation recovered alcohol, control 55 DEG C of temperature, pressure-
0.1MPa, obtains plant compound collecting concentrate；
Step D, the plant compound collecting concentrate that step C is obtained is freeze-dried, -60 DEG C of cryogenic temperature, freezing
Pressure 30Pa, cooling time 10h, obtains plant composite extract.
Stirring condition in the preparation method of child's sterilizing liquid described in present embodiment, step 2 turns for stirring
Fast 200rad/min, mixing time 5min.
Stirring condition in the preparation method of child's sterilizing liquid described in present embodiment, step 3 turns for stirring
Fast 200rad/min, mixing time 5min.
Stirring condition in the preparation method of child's sterilizing liquid described in present embodiment, step 4 turns for stirring
Fast 200rad/min, mixing time 15min.
Described child prepared by present embodiment carries out irritation test test with sterilizing liquid, and method of testing is divided into
Multiple intact skin irritant test and disposable damaged skin irritant test：
Multiple intact skin Irritation Test Method is the healthy white rabbits 3 of selection body weight 20-25kg, and 24h will before experiment
The hair of white rabbit back backbone both sides is cut, the left and right each about 3cm*3cm of unhairing scope.Next day, by child's sterilizing liquid
Stoste 0.5ml is uniformly applied to side skin of unhairing surface, and opposite side skin of unhairing is used as blank control.4h is smeared, with distillation
Water removes residual tested material, smears once daily, continuously smears 14d, if necessary cropping, not injured skin.After each smear
24h observes result；
The healthy white rabbits 3 of disposable damaged skin irritant test selection body weight 20-25kg, test preceding 24h by rabbit
The hair of back backbone both sides is cut, the left and right each about 3cm*3cm of unhairing scope.Next day, first sterilized with concentration for 75% alcohol wipe
Unhairing area skin, with the damaged wound of injection needle standardized " well " shape in dermatotome, by 0.5ml child's sterilizing liquid
Stoste is dripped on the 4 layers of gauze covered on damaged part skin, is then covered with one layer of oilpaper, then solid with nonirritant adhesive plaster
It is fixed.Opposite side unhairing damaged skin, as control, is equally handled with equivalent sterile purified water with preceding work.After application 4h, with distillation
Water remove residual child use sterilizing liquid stoste, respectively at remove tested material after 1,24,48h, observation local skin reaction.
The conclusion of two groups of skin irritation tests is：Skin irritation test result shows, child is with sterilizing liquid pair
The multiple irritant test rabbit epidermis of rabbit intact skin is determined as nonirritant without significant change；To rabbit damaged skin once
Sexual stimulus is tested, and rabbit epidermis is determined as nonirritant without significant change.
Described child prepared by present embodiment carries out acute eye irritation test with sterilizing liquid and takes child to sterilize
Eye conjunctivas are intracapsular on the left of thimerosal 0.1ml, 3 rabbit of instillation, and another branch hole is used as control using sterile saline.Drip tested material
Afterwards, eye is passively closed after 4s, 30s and rinsed with sterile saline.Different time visually observes rabbit eye conjunctiva, rainbow after eye drip
The damage of film and cornea and recovery situation.
Acute eye irritation test result is that child's sterilizing liquid is instilled after rabbit eyes, 3 rabbit contamination sides after 1h
The eye conjunctiva congestion of blood vessel and slight oedema, cornea and iris not damaged；Eye irritation reaction is wholly absent in 72h, termination test.
Show that child is gentle thimerosal with sterilizing liquid by 3 groups of experiments, excitant is very little, thimerosal
In not spirituosity and western medicine composition, the healthy prevention that being adapted to child is used for usually uses.
Claims (10)
1. a kind of child's sterilizing liquid, it is characterised in that：Described child is mainly combined with sterilizing liquid by plant
Extract, glycerine, polysorbate60, preservative, deionized water are made, and its parts by weight is respectively 10~20 parts of Chinese medicine compound collecting
Thing, 5~10 parts of glycerine, 1~5 part of Tween 80,0.5~3 part of preservative, 80~100 parts of deionized water, it is described in
Medicine composite extract is mainly by cannalike dona rhizome, greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf, mile swertia herb, henry hemsleya root, selfheal, perfume
Chinese rose, small adder tongue herb, gray gum, emblic leafflower bark, folium artemisiae argyi, aloe, ginger are made.
2. child's sterilizing liquid according to claim 1, it is characterised in that：Bamboo in described plant composite extract
The parts by weight of leaf any of several broadleaf plants are 7~15 parts, the parts by weight of greater celandine are 15~20 parts, the parts by weight of the balsarm of Peru are 15~20
Part, the parts by weight of pinkflower ecdysanthera root and leaf be 10~15 parts, the parts by weight of mile swertia herb be 7~10 parts, the parts by weight of henry hemsleya root be
10~20 parts, the parts by weight of selfheal be 10~15 parts, the parts by weight of tea rose be 5~10 parts, the weight of small adder tongue herb
Amount number is 7~15 parts, the parts by weight of gray gum are 10~20 parts, the parts by weight of emblic leafflower bark are 5~10 parts, folium artemisiae argyi
Parts by weight are 20~30 parts, the parts by weight of aloe are 20~30 parts, the parts by weight of ginger are 10~20 parts.
3. child's sterilizing liquid according to claim 1 or 2, it is characterised in that：Described preservative is sorbic acid
The mixture of potassium and western pyrrole chloramines, the wherein mass ratio of potassium sorbate and western pyrrole chloramines are 1:1.
4. child's sterilizing liquid according to claim 1, it is characterised in that：In described child's sterilizing liquid
The parts by weight of plant composite extract are 10 parts, and the parts by weight of glycerine are 5 parts, and the parts by weight of Tween 80 are 1 part, anti-corrosion
The parts by weight of agent are 0.5 part, and the parts by weight of deionized water are 80 parts.
5. child's sterilizing liquid according to claim 1, it is characterised in that：In described child's sterilizing liquid
The parts by weight of plant composite extract are 20 parts, and the parts by weight of glycerine are 10 parts, and the parts by weight of Tween 80 are 5 parts, are prevented
The parts by weight of rotten agent are 3 parts, and the parts by weight of deionized water are 100 parts.
6. the preparation method of child's sterilizing liquid described in a kind of one of claim 1-5, it is characterised in that：Including as follows
Step：
The preparation of step 1, plant composite extract；
Step 2, the plant composite extract that 10~20 parts are weighed according to parts by weight respectively, 5~10 parts of glycerine, will be weighed
Plant composite extract be slowly added in glycerine, the first mixed liquor is obtained after stirring stand-by；
Step 3, the Tween 80 for weighing according to parts by weight 1~5 part respectively, 0.5~3 part of preservative, 80~100 parts go from
Sub- water, load weighted medicine is poured into deionized water, the second mixed liquor is obtained after stirring stand-by；
Step 4, by the first mixed liquor made from step 2, the second mixed liquor made from step 3 is slowly added under conditions of stirring
In, after stirring, obtain described child's sterilizing liquid.
7. the preparation method of child's sterilizing liquid according to claim 6, it is characterised in that：Plant described in step 1
The preparation of thing composite extract, comprises the following steps：
Step A, cannalike dona rhizome, greater celandine, the balsarm of Peru, pinkflower ecdysanthera root and leaf, the leafiness for weighing according to parts by weight certain mass respectively
Pellet, henry hemsleya root, selfheal, tea rose, small adder tongue herb, gray gum, emblic leafflower bark, folium artemisiae argyi, aloe, ginger, will be load weighted
Chinese medicine is respectively placed in 5~20min of crushing in Study on Supermicro-pulverization of Traditional Chinese Drugs machine, crushes acc power 1.8kw, pulverizer rotating speed 22000rad/
Min, 1~4kg/h of crushing quantity, cross 100 mesh sieves standby after crushing；
Weighed after step B, the plant powder for crushing step A are well mixed, alleged matter is poured into the plant powder mixed
10~20 times of alcoholic solution of amount, carries out alcoholic extract under the cooperation of ultrasonic wave, interruption ultrasound, per hour ultrasound 5~
15min, 1000~5000Hz of supersonic frequency, 5~10h of alcoholic extract time, take supernatant A stand-by, and remaining filter residue continues to press
Soaked once with alcoholic solution according to the above method, the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B by vacuum distillation recovered alcohol, control 55~65 DEG C of temperature, pressure-
0.1MPa, obtains plant compound collecting concentrate；
Step D, the plant compound collecting concentrate that step C is obtained is freeze-dried, -60 DEG C of cryogenic temperature, freezes pressure
30Pa, 10~20h of cooling time, obtains plant composite extract.
8. the preparation method of oral nursing liquid according to claim 6, it is characterised in that：Stirring condition in step 2 is
100~200rad/min of speed of agitator, 5~10min of mixing time.
9. the preparation method of oral nursing liquid according to claim 6, it is characterised in that：Stirring condition in step 3 is
100~200rad/min of speed of agitator, 2~5min of mixing time.
10. the preparation method of oral nursing liquid according to claim 6, it is characterised in that：Stirring condition in step 4 is
100~200rad/min of speed of agitator, 10~30min of mixing time.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107115510A (en) * | 2017-06-28 | 2017-09-01 | 长春德泰恒医疗技术有限公司 | Lotion preparation for Mucocutaneous diseases and preparation method thereof |
| CN107372477A (en) * | 2017-09-02 | 2017-11-24 | 赖进九 | A kind of agricultural composite medicine fresh-keeping for cutting flower |
| CN110565224A (en) * | 2019-08-26 | 2019-12-13 | 徐州锦业纺织科技有限公司 | Processing method of degreased rayon yarn |
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| CN105409791A (en) * | 2015-11-30 | 2016-03-23 | 芜湖悠派护理用品科技股份有限公司 | Chinese herbal medicine pet nursing mat |
| CN105617316A (en) * | 2016-01-02 | 2016-06-01 | 韩凤霞 | Antibacterial disinfectant for clinical laboratory and preparation method |
| CN106344461A (en) * | 2016-10-28 | 2017-01-25 | 皖南医学院 | Multifunctional environment-friendly infant wet tissue and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105409791A (en) * | 2015-11-30 | 2016-03-23 | 芜湖悠派护理用品科技股份有限公司 | Chinese herbal medicine pet nursing mat |
| CN105617316A (en) * | 2016-01-02 | 2016-06-01 | 韩凤霞 | Antibacterial disinfectant for clinical laboratory and preparation method |
| CN106344461A (en) * | 2016-10-28 | 2017-01-25 | 皖南医学院 | Multifunctional environment-friendly infant wet tissue and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107115510A (en) * | 2017-06-28 | 2017-09-01 | 长春德泰恒医疗技术有限公司 | Lotion preparation for Mucocutaneous diseases and preparation method thereof |
| CN107372477A (en) * | 2017-09-02 | 2017-11-24 | 赖进九 | A kind of agricultural composite medicine fresh-keeping for cutting flower |
| CN110565224A (en) * | 2019-08-26 | 2019-12-13 | 徐州锦业纺织科技有限公司 | Processing method of degreased rayon yarn |
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