CN107050234A - A kind of pharmaceutical composition for treating soft tissue injury - Google Patents
A kind of pharmaceutical composition for treating soft tissue injury Download PDFInfo
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- CN107050234A CN107050234A CN201611007452.8A CN201611007452A CN107050234A CN 107050234 A CN107050234 A CN 107050234A CN 201611007452 A CN201611007452 A CN 201611007452A CN 107050234 A CN107050234 A CN 107050234A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention relates to a kind of pharmaceutical composition for treating soft tissue injury and preparation method thereof, the pharmaceutical composition is made up of the medicine of following parts by weight：Himalayan mayapple fruit, hawthorn, stachyurus pith, leaf of negundo chastetree, sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae, the technique such as boil by alcohol extracting, decocting to be made, observation by pharmaceutical composition of the present invention to 630 soft tissue injury clinical efficacies, main clinical manifestation is pain, swelling, tenderness, ecchymosis, dysfunction, the efficient average out to 98.4% of each embodiment, effect is obvious, and adverse reaction and toxic side effect are not found, illustrate that pharmaceutical composition of the present invention is evident in efficacy in terms of soft tissue injury is treated, with good promotional value.
Description
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of pharmaceutical composition for treating soft tissue injury and its preparation
Method.
Background technology
Soft tissue injury refers to soft tissue or skeletal muscle by direct or indirect violence, or one caused by long-term chronic strain
Major class wound syndrome.Using swelling, pain as main performance.Acute stage, local oozing of blood, oedema, sharp ache.Late period may go out
Existing muscle, the adhesion of tendon, ischemic contracture, periarthritis, or even cause joint stiffness.Treatment method mainly has：1. pair
Disease etiological treatment；2. physical therapy；3. drug therapy, also can external plaster for state of an illness reasonable selection anti-inflammatory analgesic class medicine
It is affixed on affected part；4. operative treatment；5. early stage rest braking, convalescence appropriate functional training.At present, the medicine of soft tissue is treated very
Many, existing Chinese medicine also has Western medicine, there is externally applied drug, also there is innerlich anwenden, but how further to shorten the course for the treatment of, mitigates the pain of the wounded
Hardship, is current problem.
The present inventor have developed a kind of new drug to solve the above problems.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating soft tissue injury.
It is a further object of the present invention to provide a kind of preparation method for the pharmaceutical composition for treating soft tissue injury.
The present invention provides a kind of pharmaceutical composition for treating soft tissue injury, the pharmaceutical composition by following parts by weight medicine
Thing is made：10-40 parts of Himalayan mayapple fruit, 10-50 parts of hawthorn, 10-30 parts of stachyurus pith, 10-35 parts of leaf of negundo chastetree, 15-45 parts of sea-buckthorn, cockscomb
It is 10-40 parts of flower, 10-40 parts of palm, 10-40 parts of clam shell, 15-50 parts of Chinese torreyanut, 15-60 parts of Chinese violet, 10-40 parts of the bark of eucommia, sweet
It is careless 10-40 parts.
It is preferred that, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：12-38 parts of Himalayan mayapple fruit, mountain
15-45 parts of short, bristly hair or beard, 12-28 parts of stachyurus pith, 12-32 parts of leaf of negundo chastetree, 18-42 parts of sea-buckthorn, 12-38 parts of cockscomb, 12-38 parts of palm,
12-35 parts of clam shell, 20-45 parts of Chinese torreyanut, 20-55 parts of Chinese violet, 12-38 parts of the bark of eucommia, 12-38 parts of radix glycyrrhizae.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Himalayan mayapple fruit 15-35
Part, 20-40 parts of hawthorn, 15-26 parts of stachyurus pith, 15-29 parts of leaf of negundo chastetree, 22-38 parts of sea-buckthorn, 15-35 parts of cockscomb, palm 15-
35 parts, 15-32 parts of clam shell, 25-40 parts of Chinese torreyanut, 25-50 parts of Chinese violet, 15-35 parts of the bark of eucommia, 15-35 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Himalayan mayapple fruit 20-
30 parts, 25-35 parts of hawthorn, 18-23 parts of stachyurus pith, 19-25 parts of leaf of negundo chastetree, 25-35 parts of sea-buckthorn, 20-30 parts of cockscomb, palm
20-30 parts, 18-28 parts of clam shell, 28-38 parts of Chinese torreyanut, 30-45 parts of Chinese violet, 20-30 parts of the bark of eucommia, 20-30 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Himalayan mayapple fruit 25
Part, 30 parts of hawthorn, 21 parts of stachyurus pith, 22 parts of leaf of negundo chastetree, 30 parts of sea-buckthorn, 25 parts of cockscomb, 25 parts of palm, 25 parts of clam shell, Chinese torreyanut
34 parts, 38 parts of Chinese violet, 25 parts of the bark of eucommia, 25 parts of radix glycyrrhizae.
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is liquid preparation；The liquid preparation spray.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：By Himalayan mayapple fruit, hawthorn, stachyurus pith, male
Jing Ye, sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae pulverize and sieve, and are carried with pharmaceutically acceptable
Body or diluent are well mixed, are prepared into preparation.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added 3-5 times and measures water heating decoction 2-4 times, it is each 1-3 hours, filter, filter
Liquid is concentrated and dried, and is ground into fine powder, standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, 6-8 times of radix glycyrrhizae addition are measured decocting and boils 2-4
Secondary, each 1-3 hours, filtering, merging filtrate, filtrate is concentrated and dried, and is ground into fine powder standby；Filter residue adds 6-9 times and measures 75%
Ethanol soak 3-6 hour, filtering, filtrate concentrate drying, be ground into fine powder, it is standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
It is preferred that, the preparation method of pharmaceutical composition of the present invention comprises the following steps：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of amount refers to the weight ratio of medicinal material again.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in adhesive, disintegrant, lubricant, surfactant or flavouring.
Wherein described filler is selected from starch, sucrose, lactose, mannitol, sorbierite, xylitol, microcrystalline cellulose or Portugal
Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginates, gelatin or polyvinylpyrrolidone etc.；
The disintegrant is selected from microcrystalline cellulose, sodium carboxymethyl starch, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or Ac-Di-Sol；
The lubricant is selected from stearic acid, polyethylene glycol, calcium carbonate, sodium acid carbonate, silica, talcum powder or stearic acid
Magnesium；
The surfactant is selected from neopelex, stearic acid, Pluronic F68, fat
Sorb is smooth or polysorbate (tween) etc. for fat acid；
The flavouring is selected from Aspartame, Sucralose or saccharin sodium.
The invention has the advantages that：
Observation by pharmaceutical composition of the present invention to 630 soft tissue injury clinical efficacies, main clinical manifestation is pain
Bitterly, swelling, tenderness, ecchymosis, dysfunction, the efficient average out to 98.4% of each embodiment, effect substantially, and are not found bad
Reaction and toxic side effect, illustrate that pharmaceutical composition of the present invention is evident in efficacy in terms of soft tissue injury is treated, with good popularization
Value.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription：Himalayan mayapple fruit 10g, hawthorn 10g, stachyurus pith 10g, leaf of negundo chastetree 10g, sea-buckthorn 15g, cockscomb 10g, palm 10g,
Clam shell 10g, Chinese torreyanut 15g, Chinese violet 15g, bark of eucommia 10g, radix glycyrrhizae 10g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 3 times of amount water heating to decoct 2 times, 1 hour every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 6 times of amount decoctings to boil 2 times,
1 hour every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 6 times of amounts 75%
Bubble 3 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 2
Prescription：Himalayan mayapple fruit 40g, hawthorn 50g, stachyurus pith 30g, leaf of negundo chastetree 35g, sea-buckthorn 45g, cockscomb 40g, palm 40g,
Clam shell 40g, Chinese torreyanut 50g, Chinese violet 60g, bark of eucommia 40g, radix glycyrrhizae 40g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 5 times of amount water heating to decoct 4 times, 3 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 8 times of amount decoctings to boil 4 times,
3 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 9 times of amounts 75%
Bubble 6 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 3
Prescription：Himalayan mayapple fruit 12g, hawthorn 15g, stachyurus pith 12g, leaf of negundo chastetree 12g, sea-buckthorn 18g, cockscomb 12g, palm 12g,
Clam shell 12g, Chinese torreyanut 20g, Chinese violet 20g, bark of eucommia 12g, radix glycyrrhizae 12g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 7 times of amounts 75%
Bubble 4 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 4
Prescription：Himalayan mayapple fruit 38g, hawthorn 45g, stachyurus pith 28g, leaf of negundo chastetree 32g, sea-buckthorn 42g, cockscomb 38g, palm 38g,
Clam shell 35g, Chinese torreyanut 45g, Chinese violet 55g, bark of eucommia 38g, radix glycyrrhizae 38g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 5
Prescription：Himalayan mayapple fruit 15g, hawthorn 20g, stachyurus pith 15g, leaf of negundo chastetree 15g, sea-buckthorn 22g, cockscomb 15g, palm 15g,
Clam shell 15g, Chinese torreyanut 25g, Chinese violet 25g, bark of eucommia 15g, radix glycyrrhizae 15g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 6
Prescription：Himalayan mayapple fruit 35g, hawthorn 40g, stachyurus pith 26g, leaf of negundo chastetree 29g, sea-buckthorn 38g, cockscomb 35g, palm 35g,
Clam shell 32g, Chinese torreyanut 40g, Chinese violet 50g, bark of eucommia 5g, radix glycyrrhizae 35g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 7
Prescription：Himalayan mayapple fruit 20g, hawthorn 25g, stachyurus pith 18g, leaf of negundo chastetree 19g, sea-buckthorn 25g, cockscomb 20g, palm 20g,
Clam shell 18g, Chinese torreyanut 28g, Chinese violet 30g, bark of eucommia 20g, radix glycyrrhizae 20g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 8
Prescription：Himalayan mayapple fruit 30g, hawthorn 35g, stachyurus pith 23g, leaf of negundo chastetree 25g, sea-buckthorn 35g, cockscomb 30g, palm 30g,
Clam shell 28g, Chinese torreyanut 38g, Chinese violet 45g, bark of eucommia 30g, radix glycyrrhizae 30g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
Embodiment 9
Prescription：Himalayan mayapple fruit 25g, hawthorn 30g, stachyurus pith 21g, leaf of negundo chastetree 22g, sea-buckthorn 30g, cockscomb 25g, palm 25g,
Clam shell 25g, Chinese torreyanut 34g, Chinese violet 38g, bark of eucommia 25g, radix glycyrrhizae 25g.
Preparation method：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings to boil 3 times,
2 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；Filter residue adds the ethanol leaching of 8 times of amounts 75%
Bubble 5 hours, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration, stirring is equal
It is even, it is closed, 7 hours are stood, in filling device spray bottle, spray is produced.
In order to further inquire into beneficial effects of the present invention, inventor has carried out clinical test, specific as follows：
1st, general information
630 patients are chosen in volunteer, age 9-66 Sui, trauma time is most short 2 minutes, most long 48 hours, owned
Case checks heel row except fracture and the situation of abarticulation through X pieces.
2nd, test method：9 groups are randomly divided into, respectively using 1-9 of embodiment of the present invention medicine.Uniformly it is sprayed on damage
Place, five times a day.
3rd, treatment results：
3.1st, reference《New Chinese medicine guideline of clinical investigations》In relevant standard formulation point system, by its clinical manifestation journey
The different point three-levels of degree are scored：
(1) pain：
3 points of severe, hurt like hell is lasted more than；
2 points of moderate, pain can bear, and break out often；
Slight 1 point, mild pain, when as when stop；
Normal 0 point；
(2) swelling (ruler method is good for side contrast)：
3 points of severe, swelling is obvious, centre-height ＞ 1cm；
2 points of moderate, moderate swelling, centre-height about 0.5-1cm；
Slight 1 point, swelling is lighter, centre-height ＜ 0.5cm；
Normal 0 point；
(3) tenderness：
3 points of severe, light pressure is pain or tenderness；
2 points of moderate, pain, tenderness during the pressing of medium dynamics and without tenderness；
Slight 1 point, pain during weight；
It is normal without 0 point of tenderness；
(4) ecchymosis (segmentation ruler method)：
3 points of severe, ecchymosis darkviolet, area ＞ 16cm；
2 points of moderate, ecchymosis area 4-16cm；
Slight 1 point, ecchymosis area ＜ 4cm；Without 0 point of ecchymosis；
(5) dysfunction：3 points of severe, affected part movable function is lost, and can't take care of oneself；
2 points of moderate, affected part activity moderate is limited, and life can take care of oneself, but can not do manual work；
Slight 1 point, affected part activity light restraint can be engaged in normal activity；
Function is without influence, normal 0 point of activity.
3.2nd, criterion of therapeutical effect：
Clinical cure：Symptom reduces >=95% with somatic feature score, and joint motion is normal；
It is effective：Symptom reduces >=70% with somatic feature score, and joint motion is unrestricted；
Effectively：Symptom reduces >=30% with somatic feature score, and joint motion improves；
It is invalid：Symptom is reduced less than 30% with somatic feature score, and joint motion is unchanged.
3.3 result：It is shown in Table 1.
The curative effect statistical form of table 1
| Group | Clinical recovery | It is effective | Effectively | It is invalid | It is total | Efficient (%) |
| Embodiment 1 | 65 | 4 | 1 | 0 | 70 | 100% |
| Embodiment 2 | 66 | 2 | 1 | 1 | 70 | 98.6% |
| Embodiment 3 | 64 | 4 | 1 | 1 | 70 | 98.6% |
| Embodiment 4 | 63 | 4 | 1 | 2 | 70 | 97.1% |
| Embodiment 5 | 65 | 4 | 1 | 0 | 70 | 100% |
| Embodiment 6 | 63 | 4 | 1 | 2 | 70 | 97.1% |
| Embodiment 7 | 65 | 3 | 1 | 1 | 70 | 98.6% |
| Embodiment 8 | 62 | 4 | 1 | 3 | 70 | 95.7% |
| Embodiment 9 | 65 | 4 | 1 | 0 | 70 | 100% |
Soft tissue injury 630 is treated, the efficient average out to 98.4% of each embodiment, effect substantially, and is not found not
Good reaction and toxic side effect, illustrate that pharmaceutical composition of the present invention is evident in efficacy in treatment soft tissue injury, with good promotion price
Value.
Model case：
Case 1 shuts out certain, female, 26 years old, and during because of work accidentally, left hand is weighed wounded by machine, checks left finesse and the swelling of the back of the hand portion
Substantially, livid purple in blocks, pain with tenderness, X-ray film shows without fracture and dislocation sign.It is diagnosed as left hand spreading wound.The spray present invention is implemented
The medicine of example 1, five times a day, after 3 days, symptom mitigation is continuing with 10 days, recovery from illness.
Case 2：Field, man, 33 years old, right crus of diaphragm bruise, swelling pain, inconvenient walking sprayed the medicine group of the embodiment of the present invention 2
Compound, 5 hours/time, pain relief after 24 hours, swelling pain is completely eliminated after 5 days, and walking is fully recovered freely.
Case 3：Wu, man, 42 years old, sprains when right hand middle finger is because of work, swells and ache, and generates heat, and congestion and swelling pain sprays this hair
The bright pharmaceutical composition of embodiment 3,5 hours/time, pain relief after 24 hours continues medication 4 days, symptom eliminates recovery from illness.
The Guo of case 4, female 37 years old, sprains left ankle, substantially, local swelling is obvious, ankle-joint for left ankle external malleolus tenderness accidentally
Dorsiflexion, flexing, rotary moveable are limited.Clap X-ray and exclude fracture and dislocation sign, be diagnosed as left and right sprain of ankle joint.Spray this hair
The bright pharmaceutical composition of embodiment 4,5 hours/time, after 3 days, all diseases mitigate, and are continuing with 10 days, fully recover.
The Chinese cabbage of case 5, man, 10 years old, sprains right ankle-joint, redness and swelling of joints, crushing pain when being at play.Right ankle-joint x-ray
Piece, soft tissue swelling, no fracture is diagnosed as right sprain of ankle joint.Spray the pharmaceutical composition of the embodiment of the present invention 5,5 hours/time, 2
After it, symptom mitigation is continuing with 10 days, recovery from illness.
Case 6 shuts out certain, man, 26 years old, sprains left foot because playing soccer, and checks the swelling of the left foot back of the body substantially, livid purple in blocks, pain
Pain tenderness, X pieces show without fracture and dislocation sign.The medicine of the embodiment of the present invention 6 is sprayed, five times a day, after 3 days, symptom mitigation, after
It is continuous to use 15 days, recovery from illness.
The Xiao of case 7, man 11 years old, sprains right hand middle finger, middle finger is red and swollen, tenderness when being at play.X pieces are without fracture.Spray is originally
The pharmaceutical composition of inventive embodiments 7,5 hours/time, after 24 hours, symptom mitigation is continuing with 3 days, recovery from illness.
Case 8：Tan, man, 26 years old, sprains accidentally when right crus of diaphragm is walked, and congestion and swelling pain occurs, sprays the medicine of the embodiment of the present invention 8
Compositions, 5 hours/time, pain relief after 24 hours continues medication 2 days, symptom eliminates recovery from illness.
Case 9：Guo, female, 33 years old, left foot bruise, red and swollen, pain, inconvenient walking sprayed the medicine of the embodiment of the present invention 9
Composition, 5 hours/time, pain relief after 24 hours, swelling pain is completely eliminated after 6 days, and walking is fully recovered freely.
Although above having made to retouch in detail to the present invention with general explanation, embodiment and experiment
State, but on the basis of the present invention, some modifications can be made to it or are improved, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (10)
1. a kind of pharmaceutical composition for treating soft tissue injury, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：10-40 parts of Himalayan mayapple fruit, 10-50 parts of hawthorn, 10-30 parts of stachyurus pith, 10-35 parts of leaf of negundo chastetree, 15-45 parts of sea-buckthorn, cockscomb
10-40 parts, 10-40 parts of palm, 10-40 parts of clam shell, 15-50 parts of Chinese torreyanut, 15-60 parts of Chinese violet, 10-40 parts of the bark of eucommia, radix glycyrrhizae
10-40 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：12-38 parts of Himalayan mayapple fruit, 15-45 parts of hawthorn, 12-28 parts of stachyurus pith, 12-32 parts of leaf of negundo chastetree, 18-42 parts of sea-buckthorn, cockscomb
12-38 parts, 12-38 parts of palm, 12-35 parts of clam shell, 20-45 parts of Chinese torreyanut, 20-55 parts of Chinese violet, 12-38 parts of the bark of eucommia, radix glycyrrhizae
12-38 parts.
3. pharmaceutical composition according to claim 2, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：15-35 parts of Himalayan mayapple fruit, 20-40 parts of hawthorn, 15-26 parts of stachyurus pith, 15-29 parts of leaf of negundo chastetree, 22-38 parts of sea-buckthorn, cockscomb
15-35 parts, 15-35 parts of palm, 15-32 parts of clam shell, 25-40 parts of Chinese torreyanut, 25-50 parts of Chinese violet, 15-35 parts of the bark of eucommia, radix glycyrrhizae
15-35 parts.
4. pharmaceutical composition according to claim 3, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：20-30 parts of Himalayan mayapple fruit, 25-35 parts of hawthorn, 18-23 parts of stachyurus pith, 19-25 parts of leaf of negundo chastetree, 25-35 parts of sea-buckthorn, cockscomb
20-30 parts, 20-30 parts of palm, 18-28 parts of clam shell, 28-38 parts of Chinese torreyanut, 30-45 parts of Chinese violet, 20-30 parts of the bark of eucommia, radix glycyrrhizae
20-30 parts.
5. pharmaceutical composition according to claim 4, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：25 parts of Himalayan mayapple fruit, 30 parts of hawthorn, 21 parts of stachyurus pith, 22 parts of leaf of negundo chastetree, 30 parts of sea-buckthorn, 25 parts of cockscomb, 25 parts of palm,
25 parts of clam shell, 34 parts of Chinese torreyanut, 38 parts of Chinese violet, 25 parts of the bark of eucommia, 25 parts of radix glycyrrhizae.
6. the pharmaceutical composition according to claim any one of 1-5, it is characterised in that the pharmaceutical composition also contains pharmacy
Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, it is characterised in that described pharmaceutical composition is liquid preparation；It is described
Liquid preparation spray.
8. a kind of method for preparing the pharmaceutical composition described in claim any one of 1-5, it is characterised in that this method include with
Lower step：By Himalayan mayapple fruit, hawthorn, stachyurus pith, leaf of negundo chastetree, sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia,
Radix glycyrrhizae pulverizes and sieves, and is well mixed with pharmaceutically acceptable carrier or diluent, is prepared into preparation.
9. a kind of method for preparing any one of claim 1-5 described pharmaceutical composition, it is characterised in that this method includes following
Step：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added 3-5 times and measures water heating decoction 2-4 times, each 1-3 hours, filtering, filtrate is dense
Contracting dry, pulverize into fine powder, standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, 6-8 times of radix glycyrrhizae addition are measured decocting and boiled 2-4 times,
1-3 hours every time, filtering, merging filtrate, filtrate was concentrated and dried, and is ground into fine powder standby；75% second is measured in 6-9 times of filter residue addition
Alcohol soaks 3-6 hours, and filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration stirs, close
Close, stand 7 hours, in filling device spray bottle, produce spray.
10. the preparation method of pharmaceutical composition according to claim 9, it is characterised in that this method comprises the following steps：
1) Himalayan mayapple fruit, hawthorn, stachyurus pith are added into 4 times of amount water heating to decoct 3 times, 2 hours every time, filtering, filtrate was concentrated and dried,
Fine powder is ground into, it is standby；
2) that leaf of negundo chastetree is ground into fine powder is standby；
3) sea-buckthorn, cockscomb, palm, clam shell, Chinese torreyanut, Chinese violet, the bark of eucommia, radix glycyrrhizae are added into 7 times of amount decoctings and boils 3 times, every time 2
Hour, filtering, merging filtrate, filtrate is concentrated and dried, and is ground into fine powder standby；The ethanol immersion 5 that filter residue adds 8 times of amounts 75% is small
When, filtering, filtrate is concentrated and dried, and is ground into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds and soaked 3 hours with 2 times of 75% ethanol of amount, filtration stirs, close
Close, stand 7 hours, in filling device spray bottle, produce spray.
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| CN109316519A (en) * | 2018-11-09 | 2019-02-12 | 南宁学院 | A kind of Chinese medicine composition and preparation method thereof for treating traumatic injury |
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