CN107029277A - 使用纯化的逆向热敏聚合物的内镜粘膜切除 - Google Patents

使用纯化的逆向热敏聚合物的内镜粘膜切除 Download PDF

Info

Publication number
CN107029277A
CN107029277A CN201611014752.9A CN201611014752A CN107029277A CN 107029277 A CN107029277 A CN 107029277A CN 201611014752 A CN201611014752 A CN 201611014752A CN 107029277 A CN107029277 A CN 107029277A
Authority
CN
China
Prior art keywords
composition
purifying
volume
transition temperature
poloxamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611014752.9A
Other languages
English (en)
Chinese (zh)
Inventor
J-M.富格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Priority claimed from CN200880126231.XA external-priority patent/CN101932287B/zh
Publication of CN107029277A publication Critical patent/CN107029277A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/34Trocars; Puncturing needles
    • A61B17/3478Endoscopic needles, e.g. for infusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30Post-polymerisation treatment, e.g. recovery, purification, drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/00234Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00269Type of minimally invasive operation endoscopic mucosal resection EMR
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
CN201611014752.9A 2007-11-29 2008-12-01 使用纯化的逆向热敏聚合物的内镜粘膜切除 Pending CN107029277A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99104907P 2007-11-29 2007-11-29
US60/991049 2007-11-29
CN200880126231.XA CN101932287B (zh) 2007-11-29 2008-12-01 使用纯化的逆向热敏聚合物的内镜粘膜切除

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880126231.XA Division CN101932287B (zh) 2007-11-29 2008-12-01 使用纯化的逆向热敏聚合物的内镜粘膜切除

Publications (1)

Publication Number Publication Date
CN107029277A true CN107029277A (zh) 2017-08-11

Family

ID=40679021

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611014752.9A Pending CN107029277A (zh) 2007-11-29 2008-12-01 使用纯化的逆向热敏聚合物的内镜粘膜切除

Country Status (5)

Country Link
US (2) US20110052490A1 (enExample)
EP (1) EP2219546B1 (enExample)
JP (2) JP5613567B2 (enExample)
CN (1) CN107029277A (enExample)
WO (1) WO2009070793A1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4989309B2 (ja) 2007-05-18 2012-08-01 株式会社半導体エネルギー研究所 液晶表示装置
US9041202B2 (en) 2008-05-16 2015-05-26 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and manufacturing method of the same
US8314765B2 (en) 2008-06-17 2012-11-20 Semiconductor Energy Laboratory Co., Ltd. Driver circuit, display device, and electronic device
WO2010032638A1 (en) 2008-09-19 2010-03-25 Semiconductor Energy Laboratory Co., Ltd. Display device
TWI574423B (zh) 2008-11-07 2017-03-11 半導體能源研究所股份有限公司 半導體裝置和其製造方法
US8232947B2 (en) 2008-11-14 2012-07-31 Semiconductor Energy Laboratory Co., Ltd. Liquid crystal display device
US8461582B2 (en) 2009-03-05 2013-06-11 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and method for manufacturing the same
KR101752640B1 (ko) 2009-03-27 2017-06-30 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체장치
KR102256492B1 (ko) 2009-06-30 2021-05-26 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치 제조 방법
CN104835850B (zh) 2009-07-10 2018-10-26 株式会社半导体能源研究所 半导体器件
KR101772639B1 (ko) 2009-10-16 2017-08-29 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
CN107731931B (zh) 2009-10-21 2021-03-23 株式会社半导体能源研究所 显示装置和包括显示装置的电子设备
KR102321812B1 (ko) 2009-10-29 2021-11-03 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
KR101876473B1 (ko) 2009-11-06 2018-07-10 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치 및 반도체 장치의 제작 방법
KR102352590B1 (ko) 2009-12-18 2022-01-17 가부시키가이샤 한도오따이 에네루기 켄큐쇼 액정 표시 장치 및 전자 기기
CN102656625B (zh) 2009-12-18 2016-08-03 株式会社半导体能源研究所 用于驱动液晶显示设备的方法
KR101805378B1 (ko) 2010-01-24 2017-12-06 가부시키가이샤 한도오따이 에네루기 켄큐쇼 표시 장치와 이의 제조 방법
WO2011111549A1 (en) 2010-03-08 2011-09-15 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and manufacturing method thereof
JP5784479B2 (ja) 2010-12-28 2015-09-24 株式会社半導体エネルギー研究所 半導体装置
RU2478344C2 (ru) * 2011-03-31 2013-04-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Иркутский государственный университет Способ эндоскопической резекции слизистой желудка
KR20130043063A (ko) 2011-10-19 2013-04-29 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치 및 반도체 장치의 제작 방법
US8962386B2 (en) 2011-11-25 2015-02-24 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and method for manufacturing the same
US9312257B2 (en) 2012-02-29 2016-04-12 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device
JP2014027263A (ja) 2012-06-15 2014-02-06 Semiconductor Energy Lab Co Ltd 半導体装置およびその作製方法
KR102072340B1 (ko) 2012-11-08 2020-01-31 가부시키가이샤 한도오따이 에네루기 켄큐쇼 금속 산화물 막 및 금속 산화물 막의 형성 방법
KR102442752B1 (ko) 2013-05-20 2022-09-14 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
CN107281545A (zh) 2013-06-27 2017-10-24 里捐提司生物材料有限公司 包含聚合物蛋白质偶联物及环境响应性聚合物的组成物及其应用
TWI667520B (zh) 2013-08-28 2019-08-01 日商半導體能源研究所股份有限公司 顯示裝置
ITMI20131927A1 (it) * 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
ITMI20131924A1 (it) * 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
JP2016001712A (ja) 2013-11-29 2016-01-07 株式会社半導体エネルギー研究所 半導体装置の作製方法
AU2015212418B2 (en) * 2014-01-29 2020-01-23 Cosmo Technologies Limited Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum
KR102799986B1 (ko) 2014-11-28 2025-04-23 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치, 모듈, 및 전자 기기
JP6736321B2 (ja) 2015-03-27 2020-08-05 株式会社半導体エネルギー研究所 半導体装置の製造方法
TWI777164B (zh) 2015-03-30 2022-09-11 日商半導體能源研究所股份有限公司 半導體裝置的製造方法
JP2017022377A (ja) 2015-07-14 2017-01-26 株式会社半導体エネルギー研究所 半導体装置
KR102477518B1 (ko) 2015-10-23 2022-12-15 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치 및 전자 기기
WO2017208119A1 (en) 2016-06-03 2017-12-07 Semiconductor Energy Laboratory Co., Ltd. Metal oxide and field-effect transistor
KR101884467B1 (ko) * 2017-06-12 2018-08-02 한국맥널티 주식회사 알긴산 또는 그 약학적으로 허용되는 염과 콜로이드성 다당류를 함유하는 액상 조성물
EP3897673A4 (en) * 2018-12-21 2022-07-13 Qmark Medical Inc. HYDROGEL COMPOSITION FOR MUCOUS LIFTING IN ANATOMIC LUMEN STRUCTURES
JP7598850B2 (ja) 2019-02-22 2024-12-12 生化学工業株式会社 保存性向上方法
EP4154865A1 (en) * 2021-09-23 2023-03-29 Ovesco Endoscopy AG Process for manufacturing an injection agent and injection agent obtainable by this process

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046438A2 (en) * 2003-11-06 2005-05-26 Pluromed, Inc. Internal clamp for surgical procedures
US20060070631A1 (en) * 2004-09-27 2006-04-06 Boston Scientific Scimed, Inc. Devices and methods for agent-assisted medical procedures
CN1794980A (zh) * 2003-03-24 2006-06-28 生物领域医疗公司 利用逆向热敏聚合物的暂时栓塞

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US5567859A (en) * 1991-03-19 1996-10-22 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
DE69230372T2 (de) 1991-03-19 2000-06-15 Cytrx Corp., Norcross Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität
US5696298A (en) 1991-03-19 1997-12-09 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5800711A (en) * 1996-10-18 1998-09-01 Mdv Technologies, Inc. Process for the fractionation of polyoxyalkylene block copolymers
AU2001241958A1 (en) * 2000-03-03 2001-09-17 Valentis, Inc. Improved poloxamer and poloxamine compositions for nucleic acid delivery
GB2362100B (en) * 2000-05-08 2002-05-08 Maelor Pharmaceuticals Ltd Wound gels
US6761824B2 (en) 2000-08-17 2004-07-13 Reeve Lorraine E Process for the fractionation of polymers
TW200307011A (en) * 2002-04-18 2003-12-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modifier
US20050079147A1 (en) * 2003-10-14 2005-04-14 Bernard Delaey Wound healing compositions and uses
WO2005037062A2 (en) * 2003-10-14 2005-04-28 Pluromed, Inc. Confinement of kidney-stone fragments during lithotripsy
JP2008514640A (ja) * 2004-09-27 2008-05-08 バレンティス,インコーポレイティド 炎症性疾患治療のための製剤と方法
AU2006216420B2 (en) * 2005-02-25 2010-07-15 The Regents Of The University Of Michigan Compositions and methods for treating and preventing cardiomyopathy and heart disease
EP2601972B1 (en) * 2005-05-02 2014-11-05 Genzyme Corporation Non-lithotripsic kidney-stone therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1794980A (zh) * 2003-03-24 2006-06-28 生物领域医疗公司 利用逆向热敏聚合物的暂时栓塞
WO2005046438A2 (en) * 2003-11-06 2005-05-26 Pluromed, Inc. Internal clamp for surgical procedures
US20060070631A1 (en) * 2004-09-27 2006-04-06 Boston Scientific Scimed, Inc. Devices and methods for agent-assisted medical procedures

Also Published As

Publication number Publication date
EP2219546A4 (en) 2012-01-18
CN101932287A (zh) 2010-12-29
JP5613567B2 (ja) 2014-10-22
US20110052490A1 (en) 2011-03-03
JP2011505377A (ja) 2011-02-24
US20160317701A1 (en) 2016-11-03
WO2009070793A1 (en) 2009-06-04
EP2219546A1 (en) 2010-08-25
JP6049658B2 (ja) 2016-12-21
JP2014221205A (ja) 2014-11-27
EP2219546B1 (en) 2017-02-01

Similar Documents

Publication Publication Date Title
CN107029277A (zh) 使用纯化的逆向热敏聚合物的内镜粘膜切除
US20220354956A1 (en) Biodegradable drug delivery for hydrophobic compositions
AU2018285975B2 (en) Polymeric paste compositions for drug delivery
Xuan et al. Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam
CN1234416C (zh) 持续释放疏水药物的组合物及其制备方法
US20090148498A1 (en) Controlled release implantable dispensing device and method
CA2348922A1 (en) Polymeric systems for drug delivery and uses thereof
CN1671362A (zh) 用于药物递送的生物可降解嵌段共聚组合物
Luan et al. Thermogel loaded with low-dose paclitaxel as a facile coating to alleviate periprosthetic fibrous capsule formation
Cao et al. Safe and efficient colonic endoscopic submucosal dissection using an injectable hydrogel
US20230210790A1 (en) Gel for use in gastrointestinal endoscopy and endodermal, epidermal, and other mucosal uses
JP6250005B2 (ja) 制御放出製剤
JP2019518569A (ja) 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス
Kanellos et al. Pneumomediastinum after dilatation of anal stricture following stapled hemorrhoidopexy
CN101932287B (zh) 使用纯化的逆向热敏聚合物的内镜粘膜切除
EP4384277A1 (en) Targeted delivery of anti-csf1r antibodies
US20240399020A1 (en) Methods and material compositions for preventing non-target embolization
Balavigneswaran et al. Polymeric gels for the controlled drug delivery applications
Al-Wiswasi et al. Formulation and in vitro evaluation of in-situ gelling liquid suppositories for naproxen
Alvarez-Lorenzo et al. Poly (ethylene oxide)-poly (propylene oxide) block copolymer micelles and gels in drug delivery: state-of-the-art and future perspectives
Godfroy Polymeric micelles–the future of oral drug delivery
Bhosale In Situ Implant for the Treatment of Prostate Cancer
Dumortier et al. Expert Review

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170811

WD01 Invention patent application deemed withdrawn after publication