CN107029152A - A kind of Chinese medical extract for treating ox diarrhoea - Google Patents

A kind of Chinese medical extract for treating ox diarrhoea Download PDF

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CN107029152A
CN107029152A CN201710310360.5A CN201710310360A CN107029152A CN 107029152 A CN107029152 A CN 107029152A CN 201710310360 A CN201710310360 A CN 201710310360A CN 107029152 A CN107029152 A CN 107029152A
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extract
parts
diarrhoea
treating
chinese medical
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胡建军
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Tarim University
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a kind of Chinese medical extract for treating ox diarrhoea, it is prepared from by the raw material of following parts by weight：20 30 parts of Emilia sonchifolia extracts, 6 18 parts of astragalus polyose, 10 20 parts of fennel powder, 10 20 parts of malt extract, 10 20 parts of Endothelium Corneum Gigeriae Galli extract, 10 20 parts of Massa Medicata Fermentata extract, 40 60 parts of Honegsukle flower P.E, 15 25 parts of dipotassium glycyrrhizinate, 6 18 parts of Schisandra chinens P.E.The present invention is warming middle-Jiao and tonifying deficiency, and inner emergency, appetite-stimulating indigestion-relieving, antidiarrheal spleen-enlivening have preferable curative effect in the treatment of calf diarrhea, can improve the immunity of organisms of ox, and toxicity is low, noresidue, be not likely to produce drug resistance, and with good antiviral efficacy.

Description

A kind of Chinese medical extract for treating ox diarrhoea
Technical field
The present invention relates to field of fodder, and in particular to a kind of Chinese medical extract for treating ox diarrhoea.
Background technology
Calf diarrhea refers to the calf just in nursing period, because enterocinesia is hyperfunction, and intestinal contents absorbs incomplete or absorbs tired Difficulty, causes intestinal contents to be excreted with volume moisture, and excrement is in watery soup or water sample, and calf, which produces, to be dehydrated, acid poisoning etc. one Plant illness.Clinical manifestation is spiritual depressed, hyperpyrexia, abdominal distension, stomachache, and give up food, and short of breath, excrement stench blacks, or be mixed with Trace of blood bubble, acute a large amount of watery diarrheas, is dehydrated, acidosis symptom in progressive.It is to cause calf retarded growth and death One of principal disease, the disease is referred to as the killer of newborn calf by someone.This disease can occur throughout the year, to be born one month Interior calf morbidity and mortality highest, accounts for intestines of the calf incidence of disease or so, and sizable economic damage is caused to cattle-raising Lose.
Antibiotic, hormone, chemical synthetic drug are generally used in the treatment of diarrhoeal diseases at present, or this is added in feed A little medicines are treated and alleviating diarrhoea, but the long-term use of these materials can make pathogenic microorganism produce drug resistance, reduction Curative effect of medication.In addition, these medicines, which are largely used, causes livestock products drug residue seriously to threaten human health.
Postnatal initially several days of calf, its immunity is extremely low, at this moment needs to provide basic antibody by colostrum, to prevent Only calf produces the generation of stress reaction and disease.But, due to feeding management error, cause colostrum feeding time too late, feed Amount is very few or does not feed, causes calf to obtain maternal antibody and reduce immunity, leads to the generation of diarrhoea.
Traditional Chinese veterinary medicine thinks that calf is young sun, and the body qi and blood of young sun does not fill, and internal organs are tender and lovely, and taste element is weak, thus spleen is normal not Foot, such as feeding management is improper, and fever and chills are uncomfortable and chill summer-heat and damp is invaded, and cause dysfunction of spleen and stomach and suffer from diarrhoea.
The content of the invention
To solve the above problems, the invention provides a kind of Chinese medical extract for treating ox diarrhoea, it is warming middle-Jiao and tonifying deficiency and inner slow Anxious, appetite-stimulating indigestion-relieving, antidiarrheal spleen-enlivening have preferable curative effect in the treatment of calf diarrhea, can improve the immunity of organisms of ox, toxicity Low, noresidue, it is not likely to produce drug resistance.
To achieve the above object, the technical scheme taken of the present invention is：
A kind of Chinese medical extract for treating ox diarrhoea, is prepared from by the raw material of following parts by weight：
20-30 parts of Emilia sonchifolia extracts, 6-18 parts of astragalus polyose, 10-20 parts of fennel powder, 10-20 parts of malt extract, 10-20 parts of Endothelium Corneum Gigeriae Galli extract, 10-20 parts of Massa Medicata Fermentata extract, 40-60 parts of Honegsukle flower P.E, dipotassium glycyrrhizinate 15-25 Part, 6-18 parts of Schisandra chinens P.E.
Preferably, the Emilia sonchifolia extracts are as obtained by prepared by following steps：
Dry tassel flower is placed in 90% methanol or ethanol solution that flash extracter adds 6 times of volumes, 3-6 points of processing After clock, separation of solid and liquid, methanol or ethanol solution, concentration are reclaimed so that extract is in paste, then with water-saturated n-butanol to carrying Take thing to extract 3 times, after recycling design, extract is concentrated in vacuo drying, Emilia sonchifolia extracts are obtained.
Preferably, the Honegsukle flower P.E is as obtained by prepared by following steps：
S1, it will clean and drain rear honeysuckle and carry out ultramicro grinding processing, after the completion of crushing, 3-8 times of water is added into powder, Cellulase is added for 0.5-2% ratio by mass percentage, 0.5-2h is digested at 30-50 DEG C, filtered, high temperature goes out enzyme, obtains Enzymolysis liquid；
S2, by the enzymolysis liquid of gained with 3-7BV/h flow velocity by macroporous resin column, after Dynamic Adsorption saturation, spend from Sub- water is colourless to efflux with the 5-8BV/h above-mentioned macroporous resin column of flow velocity elution, then the second for being 50%-70% with volume fraction Alcohol is eluted with 8-12BV/h flow velocity, is collected eluent, is concentrated under reduced pressure, obtains medicinal extract；
S3, medicinal extract water is dissolved after with 3-5BV/h flow velocity by polyamide column, after Dynamic Adsorption saturation, use 3-7BV Deionized water elutes above-mentioned polyamide column, then the ethanol water for being 30%-50% with volume fraction with 2-10BV/h flow velocity Eluted with 5-10BV/h flow velocity, collection has eluent, be spray-dried, obtain Honegsukle flower P.E.
Preferably, the Massa Medicata Fermentata extract is as obtained by prepared by following steps：
After Medicated Leaven ultramicro grinding, with distilled water immersion 10 days, low salt solutions soaked 3-4 days, pulled out, with cellulose Enzyme-pectinase solution is hybridly prepared into mixed liquor, and temperature control will be mixed at 32-42 DEG C using pipeline high shear grinding machine Liquid interval is crushed 2-3 times, obtains Massa Medicata Fermentata extract
Preferably, the Endothelium Corneum Gigeriae Galli extract is as obtained by prepared by following steps：
The clean the membrane of a chicken's gizzard is placed in enzymatic vessel, is by mass percentage 3-5% addition neutral proteinases, 20-30 DEG C, Enzymolysis 1-2 hours, per half an hour, once, control pH value is between 3.5-6.2 for stirring, oxygenation；Digest enzymolysis liquid liter after terminating Temperature is to 85-100 DEG C, and go out enzyme 30-40 minute, filters, obtains Endothelium Corneum Gigeriae Galli extract.
Preferably, the Schisandra chinens P.E is as obtained by prepared by following steps：
The dry fruit of Chinese magnoliavine is placed in after flash extracter processing, Nadou enzyme, 20- is added by mass percentage for 3-5% 30 DEG C, digest 1-2 hours, per half an hour, once, control pH value is between 3.5-6.2 for stirring, oxygenation；Enzymolysis will enzymolysis after terminating Liquid is warming up to 85-100 DEG C, and go out enzyme 30-40 minutes, adds 90% ethanol solution of 6 times of volumes, handles 1-3 minutes, separation of solid and liquid Afterwards, ethanol solution is reclaimed, concentration obtains Schisandra chinens P.E.
Preferably, the malt extract is as obtained by prepared by following steps：
Take malt to clean to drain after overtemperature crushing, carry out CO2Supercritical extract, fluid extraction pressure is 30-50MPa, extraction Take 30-40 DEG C of temperature, CO2Fluid flow is 750-850L/h, and extraction time is 3-5h, obtains malt extract.
Preferably, the volume ratio of the cellulase-pectinase solution cellulase and pectase is 1:1.
The invention has the advantages that：
It is warming middle-Jiao and tonifying deficiency, and inner emergency, appetite-stimulating indigestion-relieving, antidiarrheal spleen-enlivening, there is preferable curative effect, energy in the treatment of calf diarrhea The immunity of organisms of ox is improved, toxicity is low, noresidue, be not likely to produce drug resistance, and with good antiviral efficacy.
Embodiment
In order that objects and advantages of the present invention are more clearly understood, the present invention is carried out with reference to embodiments further Describe in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair It is bright.
Emilia sonchifolia extracts are as obtained by prepared by following steps used in following examples：
Dry tassel flower is placed in 90% methanol or ethanol solution that flash extracter adds 6 times of volumes, 3-6 points of processing After clock, separation of solid and liquid, methanol or ethanol solution, concentration are reclaimed so that extract is in paste, then with water-saturated n-butanol to carrying Take thing to extract 3 times, after recycling design, extract is concentrated in vacuo drying, Emilia sonchifolia extracts are obtained.
The Honegsukle flower P.E is as obtained by prepared by following steps：
S1, it will clean and drain rear honeysuckle and carry out ultramicro grinding processing, after the completion of crushing, 3-8 times of water is added into powder, Cellulase is added for 0.5-2% ratio by mass percentage, 0.5-2h is digested at 30-50 DEG C, filtered, high temperature goes out enzyme, obtains Enzymolysis liquid；
S2, by the enzymolysis liquid of gained with 3-7BV/h flow velocity by macroporous resin column, after Dynamic Adsorption saturation, spend from Sub- water is colourless to efflux with the 5-8BV/h above-mentioned macroporous resin column of flow velocity elution, then the second for being 50%-70% with volume fraction Alcohol is eluted with 8-12BV/h flow velocity, is collected eluent, is concentrated under reduced pressure, obtains medicinal extract；
S3, medicinal extract water is dissolved after with 3-5BV/h flow velocity by polyamide column, after Dynamic Adsorption saturation, use 3-7BV Deionized water elutes above-mentioned polyamide column, then the ethanol water for being 30%-50% with volume fraction with 2-10BV/h flow velocity Eluted with 5-10BV/h flow velocity, collection has eluent, be spray-dried, obtain Honegsukle flower P.E.
The Massa Medicata Fermentata extract is as obtained by prepared by following steps：
After Medicated Leaven ultramicro grinding, with distilled water immersion 10 days, low salt solutions soaked 3-4 days, pulled out, with cellulose Enzyme-pectinase solution is hybridly prepared into mixed liquor, and temperature control will be mixed at 32-42 DEG C using pipeline high shear grinding machine Liquid interval is crushed 2-3 times, obtains Massa Medicata Fermentata extract；The body of the cellulase-pectinase solution cellulase and pectase Product is than being 1:1.
The Endothelium Corneum Gigeriae Galli extract is as obtained by prepared by following steps：
The clean the membrane of a chicken's gizzard is placed in enzymatic vessel, is by mass percentage 3-5% addition neutral proteinases, 20-30 DEG C, Enzymolysis 1-2 hours, per half an hour, once, control pH value is between 3.5-6.2 for stirring, oxygenation；Digest enzymolysis liquid liter after terminating Temperature is to 85-100 DEG C, and go out enzyme 30-40 minute, filters, obtains Endothelium Corneum Gigeriae Galli extract.
The Schisandra chinens P.E is as obtained by prepared by following steps：
The dry fruit of Chinese magnoliavine is placed in after flash extracter processing, Nadou enzyme, 20- is added by mass percentage for 3-5% 30 DEG C, digest 1-2 hours, per half an hour, once, control pH value is between 3.5-6.2 for stirring, oxygenation；Enzymolysis will enzymolysis after terminating Liquid is warming up to 85-100 DEG C, and go out enzyme 30-40 minutes, adds 90% ethanol solution of 6 times of volumes, handles 1-3 minutes, separation of solid and liquid Afterwards, ethanol solution is reclaimed, concentration obtains Schisandra chinens P.E.
The malt extract is as obtained by prepared by following steps：
Take malt to clean to drain after overtemperature crushing, carry out CO2Supercritical extract, fluid extraction pressure is 30-50MPa, extraction Take 30-40 DEG C of temperature, CO2Fluid flow is 750-850L/h, and extraction time is 3-5h, obtains malt extract.
Embodiment 1
A kind of Chinese medical extract for treating ox diarrhoea, is prepared from by the raw material of following parts by weight：
25 parts of Emilia sonchifolia extracts, 14 parts of astragalus polyose, 15 parts of fennel powder, 15 parts of malt extract, the membrane of a chicken's gizzard are extracted 15 parts of thing, 15 parts of Massa Medicata Fermentata extract, 50 parts of Honegsukle flower P.E, 20 parts of dipotassium glycyrrhizinate, 12 parts of Schisandra chinens P.E.
Embodiment 2
A kind of Chinese medical extract for treating ox diarrhoea, is prepared from by the raw material of following parts by weight：
20 parts of Emilia sonchifolia extracts, 6 parts of astragalus polyose, 10 parts of fennel powder, 10 parts of malt extract, Endothelium Corneum Gigeriae Galli extract 10 parts, 10 parts of Massa Medicata Fermentata extract, 40 parts of Honegsukle flower P.E, 15 parts of dipotassium glycyrrhizinate, 6 parts of Schisandra chinens P.E.
Embodiment 3
A kind of Chinese medical extract for treating ox diarrhoea, is prepared from by the raw material of following parts by weight：
30 parts of Emilia sonchifolia extracts, 18 parts of astragalus polyose, 20 parts of fennel powder, 20 parts of malt extract, the membrane of a chicken's gizzard are extracted 20 parts of thing, 20 parts of Massa Medicata Fermentata extract, 60 parts of Honegsukle flower P.E, 25 parts of dipotassium glycyrrhizinate, 18 parts of Schisandra chinens P.E.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (8)

1. a kind of Chinese medical extract for treating ox diarrhoea, it is characterised in that be prepared from by the raw material of following parts by weight：
20-30 parts of Emilia sonchifolia extracts, 6-18 parts of astragalus polyose, 10-20 parts of fennel powder, 10-20 parts of malt extract, in chicken Golden extract 10-20 parts, 10-20 parts of Massa Medicata Fermentata extract, 40-60 parts of Honegsukle flower P.E, 15-25 parts of dipotassium glycyrrhizinate, five 6-18 parts of taste seed extract.
2. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 1, it is characterised in that the Emilia sonchifolia extracts As obtained by prepared by following steps：
Dry tassel flower is placed in 90% methanol or ethanol solution that flash extracter adds 6 times of volumes, handled 3-6 minutes, After separation of solid and liquid, methanol or ethanol solution, concentration are reclaimed so that extract is in paste, then with water-saturated n-butanol to extracting Thing is extracted 3 times, and after recycling design, extract is concentrated in vacuo into drying, Emilia sonchifolia extracts are obtained.
3. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 1, it is characterised in that the Honegsukle flower P.E As obtained by prepared by following steps：
S1, it will clean and drain rear honeysuckle and carry out ultramicro grinding processing, and after the completion of crushing, 3-8 times of water be added into powder, by matter Measure percentage and add cellulase for 0.5-2% ratio, digest 0.5-2h at 30-50 DEG C, filter, high temperature goes out enzyme, must digest Liquid；
S2, by the enzymolysis liquid of gained with 3-7BV/h flow velocity by macroporous resin column, after Dynamic Adsorption saturation, use deionized water Above-mentioned macroporous resin column is eluted with 5-8BV/h flow velocity colourless to efflux, then the ethanol for being 50%-70% with volume fraction with 8-12BV/h flow velocity is eluted, and is collected eluent, is concentrated under reduced pressure, obtains medicinal extract；
S3, medicinal extract water is dissolved after with 3-5BV/h flow velocity by polyamide column, after Dynamic Adsorption saturation, gone with 3-7BV from Sub- water elutes above-mentioned polyamide column with 2-10BV/h flow velocity, then the ethanol water for being 30%-50% with volume fraction is with 5- 10BV/h flow velocity is eluted, and collection has eluent, is spray-dried, is obtained Honegsukle flower P.E.
4. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 1, it is characterised in that the Massa Medicata Fermentata extract As obtained by prepared by following steps：
After Medicated Leaven ultramicro grinding, with distilled water immersion 10 days, low salt solutions soaked 3-4 days, pulled out, with cellulase-fruit Glue enzyme solutions are hybridly prepared into mixed liquor, temperature control at 32-42 DEG C, using pipeline high shear grinding machine by mixed liquor interval Crush 2-3 times, obtain Massa Medicata Fermentata extract.
5. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 1, it is characterised in that the Endothelium Corneum Gigeriae Galli extract As obtained by prepared by following steps：
The clean the membrane of a chicken's gizzard is placed in enzymatic vessel, neutral proteinase, 20-30 DEG C, enzymolysis is added by mass percentage for 3-5% 1-2 hours, per half an hour, once, control pH value was between 3.5-6.2 for stirring, oxygenation；Enzymolysis liquid is warming up to by enzymolysis after terminating 85-100 DEG C, go out enzyme 30-40 minutes, and filtering obtains Endothelium Corneum Gigeriae Galli extract.
6. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 1, it is characterised in that the Schisandra chinens P.E As obtained by prepared by following steps：
The dry fruit of Chinese magnoliavine is placed in after flash extracter processing, is by mass percentage 3-5% addition Nadou enzymes, 20-30 DEG C, Enzymolysis 1-2 hours, per half an hour, once, control pH value is between 3.5-6.2 for stirring, oxygenation；Digest enzymolysis liquid liter after terminating Temperature is to 85-100 DEG C, and go out enzyme 30-40 minute, adds 90% ethanol solution of 6 times of volumes, processing 1-3 minutes, after separation of solid and liquid, Ethanol solution is reclaimed, concentration obtains Schisandra chinens P.E.
7. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 1, it is characterised in that the malt extract leads to Cross following steps and prepare gained：
Take malt to clean to drain after overtemperature crushing, carry out CO2Supercritical extract, fluid extraction pressure is 30-50MPa, extraction temperature 30-40 DEG C, CO2Fluid flow is 750-850L/h, and extraction time is 3-5h, obtains malt extract.
8. a kind of Chinese medical extract for treating ox diarrhoea as claimed in claim 4, it is characterised in that the cellulase-fruit The volume ratio of glue enzyme solutions cellulase and pectase is 1:1.
CN201710310360.5A 2017-05-03 2017-05-03 A kind of Chinese medical extract for treating ox diarrhoea Pending CN107029152A (en)

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CN109432389A (en) * 2018-12-28 2019-03-08 河北肽都生物科技有限公司 A kind of Chinese medicine peptide for treating bovine viral diarrhoea, drug and preparation method thereof
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Application publication date: 20170811