CN107029139B

CN107029139B - Traditional Chinese medicine composition and preparation for clearing phlegm and moistening lung and preparation method thereof

Info

Publication number: CN107029139B
Application number: CN201710369159.4A
Authority: CN
Inventors: 王安军; 俞琦
Original assignee: Guiyang College of Traditional Chinese Medicine
Current assignee: Guizhou University of Traditional Chinese Medicine
Priority date: 2017-05-23
Filing date: 2017-05-23
Publication date: 2020-12-29
Anticipated expiration: 2037-05-23
Also published as: CN107029139A

Abstract

The invention provides a traditional Chinese medicine composition for clearing phlegm and moistening lung, a preparation and a preparation method thereof, the traditional Chinese medicine composition is prepared from traditional Chinese medicines of wrinkled gianthyssop, fingered citron, perilla leaves, red tangerine peel, lotus leaves, heartleaf houttuynia herb, white mulberry root-bark, bamboo juice and peppermint oil, the formula dosage is reasonable, the structure is strict, the medicine property is mild, and the traditional Chinese medicine composition has the effects of clearing phlegm and moistening lung, ventilating and discharging pus; the composition can be directly ground into powder and mixed or the active ingredients extracted by the conventional extraction technology in the field are combined with pharmaceutically acceptable pharmaceutic adjuvants to prepare various pharmaceutical dosage forms; the composition can also be prepared into a mask containing traditional Chinese medicines, has an improvement effect on discomfort of the throat and the lung caused by air particulate pollution and smoking, and has a remarkable curative effect.

Description

Traditional Chinese medicine composition and preparation for clearing phlegm and moistening lung and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and preparation for clearing phlegm and moistening lung and a preparation method thereof.

Background

In recent years, the air pollution in China has the composite characteristic of coexistence of the traditional soot type pollution and the motor vehicle tail gas type pollution, and Particulate Matters (PM) are still the primary air pollutants in most cities in China. The environmental pollution threatens the health of human beings, the atmospheric pollution is the most important component in the environmental pollution, and the atmospheric particulates are the main component of the atmospheric pollution, and the atmospheric particulates have the characteristics of strong toxicity and great harm to human bodies, and at present, the atmospheric particulates are used as the marker pollutants for evaluating the quantitative health hazard of the atmospheric pollution in China. The composite type characteristics of air pollution in partial areas of China are increasingly obvious, and the novel air pollution problems of dust haze, photochemical smog and the like are increasingly prominent, thereby forming a serious threat to the health of the masses of people and becoming a great environmental problem with high attention of all circles of the society. In addition, smoking has a particularly serious impact on the health of the population. Chinese smoking harm health report (it is pointed out that more than 3.0 hundred million of Chinese smokers and about 7.4 hundred million of non-smokers suffer from second-hand smoking, and smoking can cause various diseases such as chronic obstructive pulmonary disease, chronic pharyngolaryngitis, etc.

As people who are exposed in the environment polluted by the particles for a long time, the environmental sanitation workers have high probability of suffering from sphagitis and lung discomfort, and a method for reducing and lightening the harm caused by the direct inhalation of the particles into the lungs is urgently needed to be found, so that the health of the environmental sanitation workers is ensured. In addition, how to reduce and alleviate the harm to human beings caused by environmental particulate pollution and improve the health of smoking people is also an urgent problem to be solved in the economic development process.

Disclosure of Invention

In order to solve the problems, the invention provides a traditional Chinese medicine composition for clearing phlegm and moistening lung, which is prepared from 20-46 parts of wrinkled gianthyssop herb, 10-28 parts of finger citron, 10-28 parts of perilla leaf, 10-28 parts of red tangerine peel, 8-22 parts of lotus leaf, 8-22 parts of heartleaf houttuynia herb, 9-25 parts of white mulberry root-bark, 10-28 parts of bamboo juice and 5-18 parts of peppermint oil in parts by weight.

Specifically, the method comprises the following steps: the invention provides a traditional Chinese medicine composition for clearing phlegm and moistening lung, which is prepared from 28-35 parts of wrinkled gianthyssop herb, 17-22 parts of finger citron, 17-22 parts of perilla leaf, 17-22 parts of tangerine peel, 12-18 parts of lotus leaf, 12-18 parts of heartleaf houttuynia herb, 15-20 parts of white mulberry root-bark, 15-20 parts of bamboo juice and 9-14 parts of peppermint oil in parts by weight.

More specifically, the invention provides a traditional Chinese medicine composition for clearing phlegm and moistening lung, which is prepared from 31 parts of wrinkled gianthyssop herb, 20 parts of finger citron, 20 parts of perilla leaf, 20 parts of red tangerine peel, 15 parts of lotus leaf, 15 parts of heartleaf houttuynia herb, 17 parts of white mulberry root-bark, 17 parts of bamboo juice and 12 parts of peppermint oil in parts by weight.

The composition can be directly ground into powder and mixed or the active ingredients extracted by the conventional extraction technology in the field and pharmaceutically acceptable pharmaceutic adjuvants are prepared into various pharmaceutical dosage forms.

The medicinal adjuvants can be sweetener, sour agent, antiseptic, wetting agent, lubricant, wetting agent, disintegrating agent, diluent and adhesive.

The invention also provides a preparation method of the traditional Chinese medicine composition for clearing phlegm and moistening lung, which comprises the following steps:

decocting herba agastaches, fingered citron, perilla leaves, exocarpium citri rubrum, lotus leaves, houttuynia cordata, white mulberry root-bark and bamboo juice in water twice by a water extraction method, adding 10 times of water of the total amount of the medicinal materials for the first time, decocting for 2 hours, filtering by 200 meshes to obtain filtrate for later use, adding 8 times of water for decocting for 1 hour for the second time, filtering by 200 meshes, combining the filtrates of the two times, and concentrating the extracting solution at 60 ℃ under reduced pressure until the relative density is 1.10-1.15 to obtain concentrated solution; and then the concentrated solution, the peppermint oil and pharmaceutically acceptable pharmaceutic adjuvants are prepared into various pharmaceutical dosage forms.

The medicament dosage forms are oral liquid, tablets, capsules, granules, pills and film medicament membranes.

The invention also provides a preparation method of the mask containing traditional Chinese medicines, which comprises the following steps:

taking 8-12 parts of white vaseline, 2-6 parts of glycerol and 1-3 parts of peppermint oil by weight, uniformly stirring, adding 5-10 parts of concentrated solution by weight, uniformly grinding to form cream, coating the cream on gauze with the diameter of 3cm multiplied by 3cm, drying at the temperature of 30-42 ℃, and putting the cream into an interlayer cut by a common mask to obtain the mask.

Further, the preparation method of the mask containing traditional Chinese medicines comprises the following steps:

taking 10 parts by weight of white vaseline, 4 parts by weight of glycerol and 2 parts by weight of peppermint oil, uniformly stirring, adding 8 parts by weight of concentrated solution, uniformly grinding to form cream, coating the cream on gauze with the thickness of 3cm multiplied by 3cm, drying at 38 ℃, and putting the cream into an interlayer cut by a common mask to obtain the ointment.

The invention uses the following components with the characteristics and effects:

agastache rugosus: is the whole herb of patchouli or agastache rugosus of Labiatae family; pungent and mild-warm; fast qi, harmonize middle energizer, avoid filthy, dispel dampness. It is used to treat common cold with summer-heat and dampness, cold and heat, headache, fullness and distention in chest and abdomen, emesis, diarrhea, malaria, dysentery, and halitosis.

Fingered citron: is dried fruit of Citrus medica L.var.sarcodactylis Swingle of Citrus of Rutaceae; pungent, bitter, sour, warm; soothing liver, regulating qi, harmonizing stomach and relieving pain. Can be used for treating qi stagnation of liver and stomach, distending pain in chest and hypochondrium, fullness and distention in stomach, anorexia, and emesis.

And (3) perilla leaves: dried leaves (or shoots) of Perilla frutescens (L.) Britt, a plant of Labiatae; pungent and warm; relieve exterior syndrome, dispel cold, move qi and harmonize stomach. Can be used for treating wind-cold type common cold, cough, emesis, vomiting of pregnancy, and fish and crab poisoning.

Orange peel: dried outer peel of Citrus reticulata Blanco and cultivars thereof, Citrus grandis Osbeck var. tomentosa Hort, a Rutaceae plant; pungent, bitter and warm; dispel cold, dry dampness, promote qi circulation and resolve phlegm. Can be used for treating cough due to wind-cold evil, itching throat, excessive phlegm, food stagnation, alcohol injury, nausea, vomiting, and stuffiness.

Lotus leaf: the traditional Chinese medicine holds that the lotus leaves are bitter and astringent in flavor and neutral, and enter liver, spleen, stomach and heart channels. Has effects of clearing summer-heat, promoting diuresis, raising hair, clearing yang, cooling blood, and stopping bleeding. But also has the function of mitosis resistance and stronger bacteriostatic effect. It also has health promoting effect when drinking more.

Houttuynia cordata: the herba Houttuyniae can enhance phagocytosis of WBC and increase serum properdin, and when used for treating chronic tracheitis, the synthesized houttuynin can significantly improve the phagocytosis of white staphylococcus by WBC and increase serum properdin.

White mulberry root-bark: sweet in nature and taste and cold in nature. Enter the lung meridian. Has the effects of purging the lung, relieving asthma, promoting diuresis and relieving swelling

Bamboo juice: heated outflow of bamboo juice from Phyllostachys nigra (Lodd.) Munro var. hennonis (Mitf.) Stapf ex Rendle of Gramineae; sweet and cool; clear heat and eliminate phlegm. Can be used for treating phlegm accumulation of middle-jiao wind, lung heat cough and asthma, and fever dysphoria.

Peppermint oil: drying the stem and leaf of herba Menthae to semi-dry, and distilling to obtain oleum Menthae Dementholatum; pungent and cool; disperse wind-heat. Clear head and eyes, promote eruption. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, and chest and hypochondrium swelling.

The principle and the beneficial effects of the invention are as follows:

the traditional Chinese medicine composition consists of agastache rugosus, fingered citron, perilla leaves, red tangerine peel, lotus leaves, houttuynia cordata, white mulberry root-bark, bamboo juice and peppermint oil, wherein the agastache rugosus is used for dispelling summer-heat, relieving exterior syndrome, and resolving dampness and harmonizing stomach; the fingered citron can regulate qi to reduce phlegm, stop vomiting and relieve distension; folium Perillae has effects in dispelling cold, relieving exterior syndrome, regulating qi-flowing, and relieving epigastric distention; exocarpium Citri rubrum for eliminating phlegm and relieving cough; the lotus leaves clear summer heat and promote diuresis, ascend hair and clear yang, cool blood and stop bleeding; herba Houttuyniae has effects of refreshing mind, clearing away heat and toxic materials; cortex Mori has effects in clearing away heat, promoting diuresis, removing toxic materials, and relieving swelling; zhu Li is effective in clearing heat, eliminating phlegm and relieving convulsion; the peppermint oil can disperse wind heat; the traditional Chinese medicines are mutually synergistic, perilla leaves in the formula are pungent and warm exterior-resolving medicines, pungent flavor is used for dispelling wind, warm and cold-dispelling, so the effect of dispelling wind cold is achieved, mint is pungent and cool exterior-resolving medicines, pungent flavor is used for dispelling wind, cold and heat-dispelling, so the effect of dispelling wind heat is achieved, wrinkled gianthyssop is used for dispelling cold and exterior-resolving, the effect of dispelling exterior-syndrome is achieved, fingered citron, red tangerine peel and bamboo juice have the effect of reducing phlegm, the white mulberry root-bark is used for clearing heat and removing toxicity, lotus leaves and houttuynia cordata have the effects of promoting qi circulation and activating blood, the lung and skin and hair are mutually exterior and interior, exogenous pathogenic factors invade the skin and. The cough-relieving and phlegm-resolving medicine has the effects of relieving cough and eliminating phlegm, can improve the lung function, ensures that lung qi is normally dispersed and descended, can better enhance the skin and hair defense function through 'lung towards all veins and essence deposition in skin and hair', is favorable for relieving exterior syndromes.

According to a large number of formula researches and clinical screening tests, the traditional Chinese medicine formula disclosed by the invention is determined to take agastache rugosus, fingered citron, perilla leaves, red tangerine peel, lotus leaves, houttuynia cordata, white mulberry root-bark, bamboo juice and peppermint oil as the composition, the composition is prepared into tablets and put into an interlayer of a mask, the tablets have the effects of clearing away the lung-heat and moistening the lung, and the tablet has the effects of improving the throat and lung discomfort caused by air particulate pollution and smoking, is remarkable in curative effect and is convenient to use.

In order to better illustrate the advantageous effects of the present invention, the following test examples are also presented in the present invention, which are intended to illustrate the advantageous effects of the present invention, but are by no means limited to the scope of protection of the present invention.

Experimental example 1 Effect of the composition of the present invention on Lung function in PM 2.5-induced Lung injury model mouse

Experimental methods

1.1 test animals

Clean-grade healthy CIR female mice 90, with a body mass of 25-27 g.

1.2 test drugs, reagents and subgroups

PM2.5 suspension: and (3) carrying out particle removal treatment on the PM2.5 of the atmospheric particulates by using deionized water and an ultrasonic oscillator, filtering, taking filtrate, freezing and drying in vacuum, taking powder, and preparing the powder into 6mg/mL PM2.5 suspension by using 0.9% sodium chloride solution.

Test group 1: concentrated solution prepared from herba Agastaches 18g, fructus Citri Sarcodactylis 8g, folium Perillae 8g, exocarpium Citri rubrum 8g, folium Nelumbinis 6g, herba Houttuyniae 6g, cortex Mori 7g, succus Bambusae 8g, and oleum Menthae Dementholatum 4 g;

test group 2: concentrated solution prepared from herba Agastaches 20g, fructus Citri Sarcodactylis 10g, folium Perillae 10g, exocarpium Citri rubrum 10g, folium Nelumbinis 8g, herba Houttuyniae 8g, cortex Mori 9g, succus Bambusae 10g, and oleum Menthae Dementholatum 5 g;

test group 3: concentrated solution prepared from herba Agastaches 28g, fructus Citri Sarcodactylis 17g, folium Perillae 17g, exocarpium Citri rubrum 17g, folium Nelumbinis 12g, herba Houttuyniae 12g, cortex Mori 15g, succus Bambusae 15g, and oleum Menthae Dementholatum 9 g;

test group 4: concentrated solution prepared from herba Agastaches 31g, fructus Citri Sarcodactylis 20g, folium Perillae 20g, exocarpium Citri rubrum 20g, folium Nelumbinis 15g, herba Houttuyniae 15g, cortex Mori 17g, succus Bambusae 17g, and oleum Menthae Dementholatum 12 g;

test group 5: concentrated solution prepared from 35g of wrinkled gianthyssop herb, 22g of finger citron, 22g of perilla leaf, 22g of red tangerine peel, 18g of lotus leaf, 18g of heartleaf houttuynia herb, 20g of white mulberry root-bark, 20g of bamboo juice and 14g of peppermint oil;

test group 6: concentrated solution prepared from herba Agastaches 46g, fructus Citri Sarcodactylis 28g, folium Perillae 28g, exocarpium Citri rubrum 28g, folium Nelumbinis 22g, herba Houttuyniae 22g, cortex Mori 25g, succus Bambusae 28g, and oleum Menthae Dementholatum 18 g;

test group 7: concentrated solution prepared from herba Agastaches 48g, fructus Citri Sarcodactylis 30g, folium Perillae 30g, exocarpium Citri rubrum 30g, folium Nelumbinis 24g, herba Houttuyniae 24g, cortex Mori 27g, succus Bambusae 30g, and oleum Menthae Dementholatum 20 g;

1.3 test methods

Establishing an animal model: 10 mice in each group are bred adaptively for 1 week, blank control groups are bred normally in the model building days 8, 14, 20 and 26 after nasal drip of 0.9% sodium chloride solution (20 mu L/mouse) in the model building days 8, 14, 20 and 26 respectively, and the mice in the other time are bred normally; the model control group adopts a method of nasal cavity instillation of PM2.5 suspension, the prepared PM2.5 suspension is instilled through nasal cavities for 8 days, 14 days, 20 days and 26 days respectively, 40mg/kg of PM2.5 suspension is established in the model, and the model of the test group 1-7 is established in the same model control group. The blank control group and the model control group were orally administered 0.5 mL/day of 0.9% sodium chloride solution from the day of molding, and the test groups 1 to 7 were orally administered 0.5 mL/day of a diluent of the concentrate (diluted with water at a ratio of 1: 7) from the day of molding.

Detection indexes are as follows: before and after the test, the test is carried out, a 1% pentobarbital is intraperitoneally injected with a deep anesthesia mouse (0.15ml/30g), the neck skin is cut off, the trachea is separated in a blunt manner, an incision of about 1.0mm is cut at the head of the trachea, the trachea joint of the intubation is inserted into the trachea and is fixed by cotton threads, the mouse is transferred to a stereograph platform, an auxiliary respirator and the trachea joint are connected, and the indexes of the lung functions of the mouse, such as RLMax, ReMax, RLArea, ReArea, Cdynmax, CdynArea, PEF and the like are recorded.

1.4 results of the experiment

1.4.1 general case:

the blank control group mice did not die, had good hair gloss, gradually increased body mass, and normal breathing and thoracic activities; 1 mouse dies in the model making period of the model control group, the hair glossiness of the surviving mouse is poor, the physical quality is increased little, and part of the mice have physical quality decline, rapid respiration, obvious thoracic activity and mental restlessness; the test groups 1-7 mice have no death, good hair glossiness, slow body mass growth, smooth breathing movement and normal thoracic movement, and the weight change of the mice in each group is shown in the following table 1:

table 1: variation in body Mass (x. + -. s, g) of mice in each group

From the table above, the model control group and the blank control group have significant difference (p <0.05), which indicates that the model building is successful, and the adverse effect of the particulate matter PM2.5 on the growth and development of animals can be effectively improved by the intervention of the administration of the test groups 1 to 7 (p <0.05 compared with the model control group), wherein the test group 4 has the most significant effect, the growth and development condition is close to the blank control group, which indicates that the influence of the drug group determined by the invention on the living condition of the mice in the PM2.5 environment can be remarkably improved.

1.4.2 mouse Lung function:

table 2: lung function status in mice:

group of	RLMax	ReMax	CdynMax	RLArea	ReArea	CdynArea	PEF
								Blank control group	9.30	7.70	20.35	9.14	8.24	16.03	19.55
Control model group	19.85	19.60	4.59	18.63	16.42	7.45	5.80
								Test group 1	10.85	11.35	10.49	10.87	13.82	12.12	10.20
Test group 2	10.15	11.00	11.26	10.25	12.67	13.45	11.50
								Test group 3	9.65	10.05	11.49	9.36	12.01	14.67	12.30
Test group 4	8.70	9.00	11.68	8.97	11.21	15.43	13.35
								Test group 5	8.85	9.05	11.64	9.06	11.28	15.07	13.15
Test group 6	9.00	9.15	11.23	9.08	11.30	14.75	13.00
								Test group 7	9.05	9.20	11.20	9.15	11.89	14.04	12.65

As can be seen from the above table, the lung function index of the model control group has significant difference (p <0.05) compared with that of the blank control group, which indicates that the molding is successful; the inspiratory resistance and the expiratory resistance (RLMax, ReMax, RLArea and ReArea) of the test groups 1-7 are all smaller than those of the model control group (p is less than 0.05), the airway compliance (CdynMax and CdynArea) and the maximum forced expiratory flow rate (PEF) of the test groups 1-7 are reduced compared with those of the blank control group, and are obviously improved compared with the model control group and are closer to the blank control group, which shows that the ventilation function of PM2.5 to mice is limited, and the traditional Chinese medicine composition has obvious curative effect on improving the lung function of the mice; the test group 4 is optimal, the test group 1 and the test group 7 are low and high components of the traditional Chinese medicine composition, the test group 1 has poor effect, and the test group 7 has no obvious effect, so the optimal formula ratio of the composition is as follows: 20-46 parts of wrinkled gianthyssop herb, 10-28 parts of fingered citron, 10-28 parts of perilla leaf, 10-28 parts of red tangerine peel, 8-22 parts of lotus leaf, 8-22 parts of heartleaf houttuynia herb, 9-25 parts of white mulberry root-bark, 10-28 parts of bamboo juice and 5-18 parts of peppermint oil, wherein the optimal formula ratio is as follows: 31 parts of wrinkled gianthyssop herb, 20 parts of finger citron, 20 parts of perilla leaf, 20 parts of red tangerine peel, 15 parts of lotus leaf, 15 parts of heartleaf houttuynia herb, 17 parts of white mulberry root-bark, 17 parts of bamboo juice and 12 parts of peppermint oil.

Test example 2: investigation of phlegm eliminating effect of traditional Chinese medicine composition

2.1 test animals

SD rat: 50 male, 180-220 g.

2.2 test drugs and groups

Positive control group: ammonium chloride 0.1g/mL

Blank control group: physiological saline

Test group 1: the concentrate obtained in example 1 was diluted 1:7 with water;

test group 2: the concentrate obtained in example 3 was diluted 1:7 with water;

test group 3: the concentrate obtained in example 5 was diluted 1:7 with water;

2.3 test methods

After 1 day of adaptive feeding, the medicine liquid with corresponding dose is administered by intragastric administration according to different groups, the medicine liquid is administered by intragastric administration of 10mL/kg, and the medicine liquid is continuously administered for 10 days. Before the experiment, the patient is fasted and not forbidden to be watered for 8-12 h, and after the last administration, the 10% chloral hydrate is 0.3 mL/100g for intraperitoneal injection anesthesia, and the patient is fixed in a supine position. The skin in the middle of the neck is cut open, the air outlet pipe is separated, a small hole is pricked between two cartilage rings at the center of the lower edge of the thyroid cartilage by using a sharp injection needle, and then a glass capillary tube which is heparinized in advance is inserted, so that the capillary tube just contacts the surface of the bottom of the trachea, and the sputum at the rear part of the trachea is sucked. When the capillary vessels were filled with sputum, another one was immediately replaced. The length of the sputum absorbed by the capillary tube is used for evaluating the phlegm-resolving effect of the medicine. The secreted sputum of each group was recorded for 2 h.

2.4 test results

Table 3 rat body weight and capillary sputum excretion (x ± s, n ═ 10)

Group of	Body weight before test	Weight at end of test	Sputum and sputum for 2h
				Positive control group	196.7±6.8	238.4±9.2	5.43±0.89
Blank control group	193.4±7.2	235.6±10.4	2.69±0.87
				Test group 1	198.9±4.6	239.9±9.3	7.64±1.25
Test group 2	195.2±5.3	237.2±8.3	8.26±1.03
				Test group 3	194.1±5.8	236.7±8.8	7.93±0.77

As can be seen from the above table, the weights of the rats in the positive control group and the test group 1-3 are not significantly different (P >0.05), the lengths of the sputum aspirated by the capillaries in the positive control group and the test group 1-3 are both significantly increased, and the significant difference (P <0.05) is compared with the blank control group, which indicates that the positive control group and the test group 1-3 can promote the discharge of the respiratory tract secretion, and have good sputum excretion function, and the lengths of the sputum aspirated by the capillaries in the test group 1-3 are higher than those in the positive control group, indicating that the sputum excretion function of the traditional Chinese medicine composition is stronger than that of the positive medicine ammonium chloride.

Test example 3: the invention discloses a traditional Chinese medicine-containing mask for investigating the curative effect

Subject: in the high haze period in winter, 60 people with symptoms of pharyngeal discomfort and dry cough exist in sanitation workers who often work outdoors.

The experimental method comprises the following steps: dividing the experimental subject into a test group, a blank group and a control group, wherein each group contains 20 persons;

test groups: the mask containing traditional Chinese medicine prepared in the embodiment 6 of the invention is dispatched to an experimental subject for use, and the using method is as follows; it is used in outdoor work every day for 7 days.

Blank group: only a common mask is used.

Control group: the haze-preventing mask manufactured according to patent CN201510988291.4 was used for the subjects in the same manner as the test groups.

The results are shown in Table 4.

Table 4: the traditional Chinese medicine-containing mask prepared by the invention has a curative effect investigation condition table (according to the number of people)

As can be seen from the above table, compared with the blank group, both the control group and the test group can significantly improve the symptoms (P <0.05) of pharyngeal discomfort, dry cough and the like of the test subject, and compared with the control group, the test group has better curative effect and the effective rate can reach 95%, which indicates that the mask containing traditional Chinese medicine prepared by the invention has significant curative effect on the symptoms of pharyngeal discomfort, dry cough and the like.

Test example 4: the mask containing traditional Chinese medicines prepared by the invention is used for improving respiratory discomfort caused by smoking:

test subjects: over 3 years of smoking, 60 smokers often have symptoms of pharyngeal discomfort, retching, excessive phlegm and the like.

The experimental method comprises the following steps: dividing the experimental subject into a test group and a blank group, wherein each group contains 30 persons;

test groups: the mask containing traditional Chinese medicine (prepared in example 6) was worn for 3 hours every day for 7 consecutive days;

blank group: 3 hours per day for 7 days;

the results are shown in Table 5.

Table 5: the mask containing traditional Chinese medicine prepared by the invention is used for improving respiratory discomfort caused by smoking (according to the number of people)

The test result shows that: compared with the blank group, the test group can effectively improve symptoms of respiratory tract pharyngeal discomfort, retching, excessive phlegm and the like caused by smoking, and the effective rate can reach 96.7 percent, which shows that the mask containing traditional Chinese medicine prepared by the invention has obvious curative effect on improving the respiratory tract discomfort caused by smoking.

The specific implementation mode is as follows:

example 1: preparation of traditional Chinese medicine composition for clearing phlegm and moistening lung

The formula is as follows: 20g of wrinkled gianthyssop herb, 10g of finger citron, 10g of perilla leaf, 10g of red tangerine peel, 8g of lotus leaf, 8g of heartleaf houttuynia herb, 9g of white mulberry root-bark, 10g of bamboo juice and 5g of peppermint oil

The preparation method comprises the following steps: decocting herba agastaches, fingered citron, perilla leaves, exocarpium citri rubrum, lotus leaves, houttuynia cordata, white mulberry root-bark and bamboo juice in water twice by a water extraction method, adding 10 times of water of the total amount of the medicinal materials for the first time, decocting for 2 hours, filtering by 200 meshes to obtain filtrate for later use, adding 8 times of water for decocting for 1 hour for the second time, filtering by 200 meshes, combining the filtrates of the two times, and concentrating the extracting solution at 60 ℃ under reduced pressure until the relative density is 1.10-1.15 to obtain concentrated solution; adding oleum Menthae Dementholatum into the concentrated solution, and mixing.

Example 2: preparation of traditional Chinese medicine composition for clearing phlegm and moistening lung

The formula is as follows: 28g of wrinkled gianthyssop herb, 17g of finger citron, 17g of perilla leaf, 17g of red tangerine peel, 12g of lotus leaf, 12g of heartleaf houttuynia herb, 15g of white mulberry root-bark, 15g of bamboo juice and 9g of peppermint oil

Example 3: preparation of traditional Chinese medicine composition for clearing phlegm and moistening lung

The formula is as follows: 31g of wrinkled gianthyssop herb, 20g of finger citron, 20g of perilla leaf, 20g of red tangerine peel, 15g of lotus leaf, 15g of heartleaf houttuynia herb, 17g of white mulberry root-bark, 17g of bamboo juice and 12g of peppermint oil

Example 4: preparation of traditional Chinese medicine composition for clearing phlegm and moistening lung

The formula is as follows: 35g of wrinkled gianthyssop herb, 22g of finger citron, 22g of perilla leaf, 22g of red tangerine peel, 18g of lotus leaf, 18g of heartleaf houttuynia herb, 20g of white mulberry root-bark, 20g of bamboo juice and 14g of peppermint oil

Example 5: preparation of traditional Chinese medicine composition for clearing phlegm and moistening lung

The formula is as follows: 46g of wrinkled gianthyssop herb, 28g of finger citron, 28g of perilla leaf, 28g of red tangerine peel, 22g of lotus leaf, 22g of heartleaf houttuynia herb, 25g of white mulberry root-bark, 28g of bamboo juice and 18g of peppermint oil

Example 6: preparation method of mask containing traditional Chinese medicine

The formula is as follows: 31g of wrinkled gianthyssop herb, 20g of finger citron, 20g of perilla leaf, 20g of red tangerine peel, 15g of lotus leaf, 15g of heartleaf houttuynia herb, 17g of white mulberry root-bark and 17g of bamboo juice

The preparation method comprises the following steps: (1) decocting herba agastaches, fingered citron, perilla leaves, exocarpium citri rubrum, lotus leaves, houttuynia cordata, white mulberry root-bark and bamboo juice in water twice by a water extraction method, adding 10 times of water of the total amount of the medicinal materials for the first time, decocting for 2 hours, filtering by 200 meshes to obtain filtrate for later use, adding 8 times of water for decocting for 1 hour for the second time, filtering by 200 meshes, combining the filtrates of the two times, and concentrating the extracting solution at 60 ℃ under reduced pressure until the relative density is 1.10-1.15 to obtain concentrated solution;

(2) taking 10g of white vaseline, 4g of glycerol and 2g of peppermint oil, uniformly stirring, adding 8g of concentrated solution, uniformly grinding to obtain an emulsion, coating the emulsion on gauze with the diameter of 3cm multiplied by 3cm, drying at 38 ℃, and putting the emulsion into an interlayer cut by a common mask to obtain the ointment.

Claims

1. The traditional Chinese medicine composition for clearing phlegm and moistening lung is characterized by comprising the following components in parts by weight: is prepared from 20-46 parts of wrinkled gianthyssop herb, 10-28 parts of fingered citron, 10-28 parts of perilla leaf, 10-28 parts of red tangerine peel, 8-22 parts of lotus leaf, 8-22 parts of heartleaf houttuynia herb, 9-25 parts of white mulberry root-bark, 10-28 parts of bamboo juice and 5-18 parts of peppermint oil;

the preparation method of the traditional Chinese medicine composition for clearing phlegm and moistening lung comprises the following steps:

decocting herba agastaches, fingered citron, perilla leaves, exocarpium citri rubrum, lotus leaves, houttuynia cordata, white mulberry root-bark and bamboo juice in water twice by a water extraction method, adding 10 times of water of the total amount of the medicinal materials for the first time, decocting for 2 hours, filtering by 200 meshes to obtain filtrate for later use, adding 8 times of water for decocting for 1 hour for the second time, filtering by 200 meshes, combining the filtrates of the two times, and concentrating the extracting solution at 60 ℃ under reduced pressure until the relative density is 1.10-1.15 to obtain concentrated solution; then the concentrated solution, the peppermint oil and pharmaceutically acceptable pharmaceutic adjuvants are prepared into various pharmaceutical dosage forms;

the medicament dosage forms are oral liquid, tablets, capsules, granules, pills and mask medicament films.

2. The traditional Chinese medicine composition according to claim 1, which is characterized in that: is prepared from 28-35 parts of wrinkled gianthyssop herb, 17-22 parts of fingered citron, 17-22 parts of perilla leaf, 17-22 parts of red tangerine peel, 12-18 parts of lotus leaf, 12-18 parts of heartleaf houttuynia herb, 15-20 parts of white mulberry root-bark, 15-20 parts of bamboo juice and 9-14 parts of peppermint oil.

3. The traditional Chinese medicine composition according to claim 1, which is characterized in that: is prepared from 31 parts of wrinkled gianthyssop herb, 20 parts of finger citron, 20 parts of perilla leaf, 20 parts of red tangerine peel, 15 parts of lotus leaf, 15 parts of heartleaf houttuynia herb, 17 parts of white mulberry root-bark, 17 parts of bamboo juice and 12 parts of peppermint oil.

4. The traditional Chinese medicine composition for clearing phlegm and moistening lung according to claim 1, wherein the pharmaceutical excipients are a sweetening agent, an acidulant, a preservative, a lubricant, a wetting agent, a disintegrating agent, a diluent and an adhesive.