CN107019093A - A kind of oral liquid of the extract containing leaf of Fructus clausenae lansii and preparation method thereof - Google Patents

A kind of oral liquid of the extract containing leaf of Fructus clausenae lansii and preparation method thereof Download PDF

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CN107019093A
CN107019093A CN201610060064.XA CN201610060064A CN107019093A CN 107019093 A CN107019093 A CN 107019093A CN 201610060064 A CN201610060064 A CN 201610060064A CN 107019093 A CN107019093 A CN 107019093A
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leaf
clausenae lansii
fructus clausenae
oral liquid
extract
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冯谟潇
潘源礼
王战
韦永然
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Guangxi Nanning Nuoer Network Communication Technology Co Ltd
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Guangxi Nanning Nuoer Network Communication Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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Abstract

The invention discloses oral liquid of a kind of extract containing leaf of Fructus clausenae lansii and preparation method thereof, using leaf of Fructus clausenae lansii as primary raw material, described preparation method is, leaf of Fructus clausenae lansii is cleaned, dried, 40-60 mesh is crushed to, by adding the leaf of Fructus clausenae lansii extract oral liquid obtained after pure water, the technical process such as ultrasonic wave extraction, clarification, filtering, concentration, 0~10% Chinese herbal medicine of addition and 0.1~0.3% sodium benzoate, sterilizing encapsulation.The leaf of Fructus clausenae lansii extract oral liquid contains abundant amino acid, protein, vitamin, antibacterial and immune substance, is prevented and cured diseases available for all kinds of domestic animals, is particularly raised pigs for nonreactive, disease prevention and cure effect is notable, manufacturing process is simple, saves the energy and time, it is easy to accomplish industrialized production.

Description

A kind of oral liquid of the extract containing leaf of Fructus clausenae lansii and preparation method thereof
Technical field
The present invention relates to a kind of oral liquid of domestic animal, especially using natural agricultural byproducts leaf of Fructus clausenae lansii extract as oral liquid of principal component and preparation method thereof.
Background technology
At present, domestic animal, poultry farming progressively move towards maximization, scale.And such aquaculture model, it if once occurring epidemic disease, very fast will soon spread, cause domestic animal, the morbidity of poultry large area, huge economic loss is caused to raiser.Therefore, raiser will be so that An ounce of prevention is worth a pound of cure.At present, what some existing domestic animals of in the market were special prevents and treats cold drug;Such as Chinese Patent Application No. discloses a kind of preventing and treating domestic animal, the preparation method of poultry bird flu oral liquid for 2008100282661, and the consumption of its raw material is:10-20 parts of the capsule of weeping forsythia, 10-25 parts of asarum, 5-20 parts of ilex pubescens, 15-30 parts of the wind-weed, 8-20 parts of chrysanthemum indicum, 10-20 parts of polygala, 10-25 parts of Chinese lobelia, 2-5 parts of snake gall, 10-25 parts of ox courage, 40-60 parts of aloe, 25-40 parts of rock sugar, 5-15 parts of Rimantadine, 3-10 parts of azithromycin.The oral liquid serves preferable prevention effect to avian influenza virus.But, its required component is more, and necessarily causing it to prepare cost can be higher;And its component is Chinese herbal medicine, having taken more the growth on domestic animal/poultry also can more or less cause certain influence.Therefore, people begin one's study, and some are not only nutritious but also can prevent and treat the composition of medicine of epidemic disease.
Clausenae Lansium(Clausena lansium (Lour.) Skeels), also known as:Yellow bullet, Calusena lansium, yellow Pi, ellow pellet, king's jar.It is clausenae Lansium golden yellow color, bright and clean dazzling, according to nature and flavor, sweet tea, sour two systems can be divided, some kind sweet and sour palatabilities, juice are abundant and have fragrance, are the fruit of excellent in color, can be with lichee and claiming.Leaf, root skin and the equal hyoscine of fruit stone.Proverb cloud among the people:" eating litchi chinesis while you are hungry, and eating calusena lansium while you are full ", illustrates that Calusena lansium can be helped digest.Clausenae Lansium is containing abundant vitamin C, sugar, organic acid and pectin;Pericarp and leaf contain volatile oil, and leaf contains phenols, glycosides displayed and amino acid again;Bark is containing a variety of alkaloids, sterol, lymphatic temperament, phenols components such as jamaicin, phellodendrine, palmatines.Fruit eliminates indigestion and phlegm, qi-regulating effect, for accumulation of food in the stomach and intes tine due to indigestion, chest the diaphragm completely disease such as pain, phlegm and retained fluid cough and asthma, and can remove stagnant heat, manage colic, leaf is pungent in flavor and cool in property, there are expelling wind to resolve the exterior, eliminating phlegm promoting the circulation of qi effect, for preventing and treating the diseases such as influenza, warm disease body heat, cough, asthma, water swelling stomachache, malaria, difficult urination, heat toxin scabies leprosy;Gen Kezhi gas pain and colic.
According to inventor's inspection information, there is not yet preparing the relevant report of the oral liquid for preventing and treating epidemic disease of domestic animal by main material of leaf of Fructus clausenae lansii.
The content of the invention
It is an object of the invention to provide a kind of domestic animal is special, disease prevention and cure effect significantly, preparation technology is simple, the oral liquid of the low extract containing leaf of Fructus clausenae lansii of production cost and preparation method thereof.
To achieve these goals, present invention employs following technical scheme:
A kind of oral liquid of the extract containing leaf of Fructus clausenae lansii, wherein, in terms of weight fraction, the oral liquid is water containing 5~40% leaf of Fructus clausenae lansii extracts, 0~10% Chinese herbal medicine, 0.1~0.3% sodium benzoate, surplus;Described Chinese herbal medicine is the composition of one or both of the capsule of weeping forsythia, walnut kernel, honeysuckle, Chinese lobelia, penholder grass, purple perilla, Asiatic plantain and field pennycress any of the above proportioning combination.
It is used as the preferred of each component content of the present invention:In terms of weight fraction, the oral liquid is water containing 15~30% leaf of Fructus clausenae lansii extracts, 5~10% Chinese herbal medicines, 0.1~0.3% sodium benzoate, surplus.
As further illustrating for the present invention, above-described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
In the oral liquid of the present invention, principle active component is leaf of Fructus clausenae lansii extract, and it contains abundant amino acid, protein, vitamin, antibacterial and immune substance, and the disease prevention and cure effect to domestic animal especially hog is very notable;And leaf of Fructus clausenae lansii wide material sources, purchasing price are also low, therefore it is easily achieved industrialized production.In order to make the disease prevention and cure of oral liquid better, the Chinese herbal medicine of some disease preventing and treatings can also be added in oral liquid.
The capsule of weeping forsythia:Medicinal plant, stem, leaf, fruit, root can be used as medicine.Its pharmacological action such as there is antibacterial, cardiac stimulant, diuresis, town to tell, the diseases such as the acute anemopyretic cold of conventional forsythia fruit for treating, carbuncle sore tumefacting virus, scrofula, urinary tract infections, are Shuanghuanglian oral liquid, dual coptis powder, heat-clearing and detoxicating oral liquid, the primary raw material for connecting the Chinese medicine preparations such as careless antipyretic oral liquid, flos ionicerae and fructus forsythiae infusion for detoxication.The capsule of weeping forsythia has broad-spectrum antibacterial action and antiinflammatory action, there is very strong inhibitory action to staphylococcus aureus, Hayes shigella dysenteriae, has certain inhibitory action to other pathogenic bacteria, influenza virus, fungi.
Walnut kernel:Also known as juglandis,semen, juglandis,semen is containing crude protein 22.18%, and the wherein composition of soluble protein is arginine and aspartic acid based on glutamic acid, secondly.Thick lipid 64.23%, wherein neutral lipid accounts for 93.05%;Aliphatic acid composition is mainly Asia acid 64.48%-69.95% and oleic acid 13.89%-15.36% in triacylglycerol 82.05% in neutral lipid, sterol ester 3.86%, the total fat of free fatty 4.80%. and neutral lipid;Triacylglycerol institute fatty acids are mainly leukotrienes 69.98;Sterol ester non-saponified portions is mainly cupreol, and has a small amount of campesterol, stigmasterol, oat steroid -5- enols, beans steroid -7- dilute alcohols;Carbohydrate 13%;A variety of free essential amino acids;Isoleucine, leucine, tryptophan, phenylalanine, valine, threonine and lysine etc., its content are the 47.50% of total amino acid.Function:The strong body of qi-restoratives, offer nutrition, anti-inflammation and sterilization, maintaining skin, Semen Persicae have direct inhibiting bacteria and diminishing inflammation to act on.According to clinical report, walnut kernel is mashed to the walnut tar zinc oxide paste being made, treatment dermatitis, eczema are efficient up to 100%.
Honeysuckle:Honeysuckle is cold in nature, sweet, enters lung, the heart, stomach, has effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind, cures mainly disease under turgor, warm disease heating, the disease such as heat toxin large carbuncle and tumour.It has certain curative effect for illnesss such as dizzy dizziness, thirst, hidrosis unhappiness, enteritis, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer furunculosis, erysipelas, parotitis, suppurative tonsillitis.
Chinese lobelia:Chinese lobelia is the whole herb with root of Campanulaceae Chinese lobelia.Effect of Chinese lobelia is clearing heat and detoxicating, inducing diuresis for removing edema.The effect of Chinese lobelia is to control venomous snake bite, carbuncle swells furunculosis, tonsillitis, warm rash, tinea pedis, traumatic injury.Chinese lobelia alias has half of flower, arrow beans grass, flag, monolithic bud, anxious solution rope, Hedyotis diffusa Willd, thin rice grass, HERBA HEDYOTIS DIFFUSAE, fish tail flower, half of chrysanthemum, Semi-pinnated Brake Herb, milk is careless with the wind, small lotus flower grass, continuous beeweed, blow that blood grass, Veronicastrum Herb, infantile malnutrition due to digestive disturbances or intestinalparasites are careless, cured grass skating, golden aster grass, golden pheasant tongue, film clips lotus, Pian Lian, the edible kernel of melon seeds be careless in vain, snake pecks careless, long cordyceps sinensis.
Penholder grass:Also known as marsh horsetail herb, hay 15~302 milligrams of % containing alkaloid, wherein having equisetine, palustridine, a small amount of nicotinamides etc..Also containing aconitic acid and Kaempferol -8- rhamnose glucose -7- glycosides, MSM, thymidine etc..It is mild-natured, sweet and slightly bitter taste.Effect:Dispelling wind, improving eyesight, promoting blood circulation, relaxing muscles and tendons.Control tearing against wind, pterygium, traumatic injury, intestines wind, bleeding.
Purple perilla:Alias is weak, red Soviet Union, common perilla, fragrant Soviet Union etc., scientific name Perillafrutescens L., are Labiatae annual herb plant.It can sweating cold dispelling it is evil with inducing diaphoresis, and can promoting the circulation of qi it is wide in, solve strongly fragrant preventing or arresting vomiting, it is therefore simultaneous seeing symptoms of emesis uncomfortable in chest to chill table disease, be very much suitable using this product;Or have the not smooth symptom of the stagnation of the circulation of vital energy without table disease, it can also be used to Xuan Tong.
Asiatic plantain:With the effect of eliminating the phlegm, antibechic, antiasthmatic effect and resisting pathogenic microbes.
Field pennycress:That is Chinese ixeris herb;Pungent, hardship, is slightly cold;It is clearing heat and detoxicating, cool blood, the carbuncle that disappears apocenosis, stasis-dispelling and pain-killing;For acute appendicitis, lung carbuncle hyperpyrexia coughs vomiting of pus and blood, and heat toxin sore malignant boil, boil pain is swollen, chest and abdomen pain, appendicitis, enteritis, dysentery, postpartum abdominal pain, dysmenorrhoea.
Sodium benzoate:Benzoic acid is also known as benzoic acid, therefore sodium benzoate is also known as sodium benzoate.Benzoic acid is insoluble in water at normal temperatures, in air(Particularly hot-air)In micro- volatilization, have hygroscopicity, about 0.34g/100ml under normal temperature;But it is dissolved in hot water;It also is soluble in ethanol, chloroform and nonvolatile oil.It is in use to select sodium benzoate more;The character and antiseptic property of benzoic acid and sodium benzoate are all similar.Sodium benzoate is mostly white particle, odorless or micro-strip styrax smell, and the micro- sweet tea of taste has convergence;It is soluble in water(Normal temperature)53.0g/100ml left and right, PH is 8 or so;Sodium benzoate is also acid preservative, without sterilization, bacteriostasis in alkaline medium;The optimal PH of its anti-corrosion is 2.5-4.0, and in PH5.0,5% solution bactericidal effect is nor very well.Sodium benzoate lipophile is larger, and easy penetration cell film enters in cell body, the permeability of interference cell film, suppresses absorption of the cell membrane to amino acid;Intracellular alkali storage is acidified into cell body internal ionization, and suppresses the activity of the breathing enzyme system of cell, acetyl coenzyme A condensation reaction is prevented, so as to play the purpose of food antiseptic.Sodium benzoate is the preservative for oral liquid preparation, and having prevents the rotten effect turned sour, extended the shelf life, and consumption excessively can produce harm to human liver, or even carcinogenic. Provided according to the state health standards of GB2760-1996, sodium benzoate must not be used in meat system food.
A kind of method for the oral liquid for preparing the above-mentioned extract containing leaf of Fructus clausenae lansii, comprises the following steps:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 40~60 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract of extraction, Chinese herbal medicine and sodium benzoate are soluble in water, and configuration contains 5~40% leaf of Fructus clausenae lansii extracts, 0~10% Chinese herbal medicine, the semi-finished product oral liquid of 0.1~0.3% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Advantages of the present invention:
The leaf of Fructus clausenae lansii extract oral liquid contains abundant amino acid, protein, vitamin, antibacterial and immune substance, integrate nutrition and drug effect, prevented and cured diseases available for all kinds of domestic animals, particularly it is used to nonreactive raise pigs, significantly, manufacturing process is simple for disease prevention and cure effect, saves the energy and time, and production cost is low, it is easy to accomplish industrialized production.
Embodiment
With reference to embodiment, the present invention is further described, but protection scope of the present invention is not limited to these embodiments.
Embodiment 1:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 5% leaf of Fructus clausenae lansii extract, 0.1% sodium benzoate, surplus.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 40 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 5% leaf of Fructus clausenae lansii extract, the semi-finished product oral liquid of 0.1% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Embodiment 2:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 40% leaf of Fructus clausenae lansii extract, 0.3% sodium benzoate, surplus.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 60 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 40% leaf of Fructus clausenae lansii extract, the semi-finished product oral liquid of 0.3% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Embodiment 3:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 25% leaf of Fructus clausenae lansii extract, 0.2% sodium benzoate, surplus.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 50 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 25% leaf of Fructus clausenae lansii extract, the semi-finished product oral liquid of 0.2% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Embodiment 4:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 5% leaf of Fructus clausenae lansii extract, 1% Chinese herbal medicine, 0.1% sodium benzoate, surplus;Described Chinese herbal medicine is the composition of the capsule of weeping forsythia, walnut kernel, honeysuckle, Chinese lobelia, penholder grass, purple perilla, Asiatic plantain and field pennycress by any proportioning combination.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 40 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 5% leaf of Fructus clausenae lansii extract, 1% Chinese herbal medicine, the semi-finished product oral liquid of 0.1% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Embodiment 5:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 40% leaf of Fructus clausenae lansii extract, 10% Chinese herbal medicine, 0.3% sodium benzoate, surplus;Described Chinese herbal medicine is the composition of the capsule of weeping forsythia, walnut kernel, honeysuckle, Chinese lobelia, penholder grass, purple perilla, Asiatic plantain and field pennycress by any proportioning combination.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 60 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 40% leaf of Fructus clausenae lansii extract, 10% Chinese herbal medicine, the semi-finished product oral liquid of 0.3% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Embodiment 6:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 15% leaf of Fructus clausenae lansii extract, 5% Chinese herbal medicine, 0.3% sodium benzoate, surplus;Described Chinese herbal medicine is the composition of the capsule of weeping forsythia, walnut kernel, Chinese lobelia, penholder grass, purple perilla, Asiatic plantain and field pennycress by any proportioning combination.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 50 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 15% leaf of Fructus clausenae lansii extract, 5% Chinese herbal medicine, the semi-finished product oral liquid of 0.3% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
Embodiment 7:
A kind of oral liquid of extract containing leaf of Fructus clausenae lansii, in terms of weight fraction, the oral liquid is water containing 30% leaf of Fructus clausenae lansii extract, 8% Chinese herbal medicine, 0.2% sodium benzoate, surplus;Described Chinese herbal medicine is the composition of the capsule of weeping forsythia, walnut kernel, honeysuckle, Chinese lobelia, penholder grass and field pennycress by any proportioning combination.Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
The preparation method of the oral liquid of the extract containing leaf of Fructus clausenae lansii is as follows:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 40 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract and sodium benzoate of extraction are soluble in water, and configuration contains 30% leaf of Fructus clausenae lansii extract, 8% Chinese herbal medicine, the semi-finished product oral liquid of 0.2% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.

Claims (4)

1. a kind of oral liquid of extract containing leaf of Fructus clausenae lansii, it is characterised in that:In terms of weight fraction, the oral liquid is water containing 5~40% leaf of Fructus clausenae lansii extracts, 0~10% Chinese herbal medicine, 0.1~0.3% sodium benzoate, surplus;Described Chinese herbal medicine is more than one or both of the capsule of weeping forsythia, walnut kernel, honeysuckle, Chinese lobelia, penholder grass, purple perilla, the Asiatic plantain and field pennycress composition by any proportioning combination.
2. the oral liquid of the extract according to claim 1 containing leaf of Fructus clausenae lansii, it is characterised in that:In terms of weight fraction, the oral liquid is water containing 15~30% leaf of Fructus clausenae lansii extracts, 5~10% Chinese herbal medicines, 0.1~0.3% sodium benzoate, surplus.
3. the oral liquid of the extract according to claim 1 or 2 containing leaf of Fructus clausenae lansii, it is characterised in that:Described leaf of Fructus clausenae lansii extract be by leaf of Fructus clausenae lansii it is cleaned, dry, crush, add water, ultrasonic wave extraction, clarification, filtering, the product obtained after concentration.
4. a kind of method for the oral liquid for preparing the extract containing leaf of Fructus clausenae lansii as described in claim 1-3 is any, it is characterised in that:Comprise the following steps:
(1)The extraction of leaf of Fructus clausenae lansii extract
After leaf of Fructus clausenae lansii is cleaned up, it is dried, crushes, then cross 40~60 mesh, adds water, ultrasonic wave extraction, clarification, filtering, leaf of Fructus clausenae lansii extract is obtained after concentration;
(2)By step(1)The leaf of Fructus clausenae lansii extract of extraction, Chinese herbal medicine and sodium benzoate are soluble in water, and configuration contains 5~40% leaf of Fructus clausenae lansii extracts, 0~10% Chinese herbal medicine, the semi-finished product oral liquid of 0.1~0.3% sodium benzoate;
(3)By step(2)Semi-finished product oral liquid sterilized, encapsulated, that is, obtain finished product oral liquid.
CN201610060064.XA 2016-01-29 2016-01-29 A kind of oral liquid of the extract containing leaf of Fructus clausenae lansii and preparation method thereof Pending CN107019093A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112450396A (en) * 2020-11-18 2021-03-09 广州合诚三先生物科技有限公司 Clausena lansium compound composition and preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112450396A (en) * 2020-11-18 2021-03-09 广州合诚三先生物科技有限公司 Clausena lansium compound composition and preparation method and application thereof

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