CN107007666A - Composition for the treatment of and improvement insomnia and its production and use - Google Patents
Composition for the treatment of and improvement insomnia and its production and use Download PDFInfo
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- CN107007666A CN107007666A CN201710278143.2A CN201710278143A CN107007666A CN 107007666 A CN107007666 A CN 107007666A CN 201710278143 A CN201710278143 A CN 201710278143A CN 107007666 A CN107007666 A CN 107007666A
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- 206010022437 insomnia Diseases 0.000 title claims abstract description 60
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 11
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- SAADBVWGJQAEFS-UHFFFAOYSA-N flurazepam Chemical compound N=1CC(=O)N(CCN(CC)CC)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1F SAADBVWGJQAEFS-UHFFFAOYSA-N 0.000 description 1
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- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 229960003987 melatonin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to medicines and health protection technical field.To solve existing treatment and improving the toxic side effect and drug dependence, tolerance of sleep Western medicine；Chinese medicine action is slowly, obvious and epiphysin health food does not influence the technical problems such as Reproductive Performance, composition that a kind for the treatment of of present invention offer and improvement are had a sleepless night and its production and use to curative effect, and the composition is made up of the component of following parts by weight：10 80 parts of spina date seed, 10 80 parts of cloves, 10 80 parts of nutmeg, 10 80 parts of black pepper, 10 80 parts of Chinese cassia tree, using carbon dioxide supercritical extraction, fully extract the active ingredient in raw material, have no toxic side effect, no dependence, without tolerance, take safety, treatment and improvement insomnia effect are notable, the crowd of being applicable extensively, is adapted to long-term taking, and for preparing treatment and improving medicine, health food or the functional food of insomnia.
Description
Technical field
The invention belongs to medicines and health protection technical field, and in particular to a kind for the treatment of and composition and its preparation for improving insomnia
Method and purposes.
Background technology
With socio-economic development, intensified competition, insomnia crowd's quantity Fast Persistence increases and shows rejuvenation trend,
Insomnia has become most commonly seen disease and the principal character of inferior health, as infringement human physical and mental health, triggers a variety of diseases
Disease and cause one of root of serious problem of society today and economic problems.
China is used as one of emphasis country of World Health Organization's " whole world sleep epidemiology survey ", Chinese Medical Association's essence
Credit can the survey showed that for refreshing disease：The people that China has 45.4% is perplexed by different degrees of insomnia, severely impacts state
The physical and mental health of the people.To improve fitness-for-all sleep consciousness, serious problem of society today and the economic problems triggered by insomnia are prevented,
WHO has carried out " whole world sleep and health plan " educational activities, and annual March 21 is set to " World Sleep Day ".
The investigation of U.S.'s hypnosphy meeting shows that there is the puzzlement that 40,000,000 people are had a sleepless night for a long time in the U.S., there is 2,000 ten thousand to 3000
The sleep of ten thousand people can not reach ideal effect.Annual 45% traffic accident, 55% industrial accident are caused by insomnia.Adjust in Europe
Look into, 66% women, 34% male suffer from insomnia, wherein 39% people is more serious.
The reason for causing insomnia is complicated, mainly there is region, environmental factor (High aititude hypoxemia)；Physiology, pathological factor (constitution
Weakness, nervous system, respiratory system, cardiovascular system, gastrointestinal system disorder etc.)；Drug factors (excitement, depression etc.).Mesh
Before, the medicine and health food for the treatment of and improvement insomnia mainly have following three class：
1st, chemical drugs species
With Benzodiazepines (diazepam (stable), Flurazepam (fludiazepam), triazolam etc.)；Barbiturates (barbital, Shandong
Rice that etc.) be main curative product.The common feature of this kind of medicine：(1) it is drug-dependent (medicine can not be departed from)：It once is discontinued
It will have a rebound, cause further aggravate of having a sleepless night；(2) drug tolerance (continuing to increase dose)：Long-term taking causes people
Internal drug accumulation, accumulation causes poisoning to a certain extent, and consequence is very serious；(3) this kind of medicine is classified as mental by country
Medicine, strict control uses crowd, uses metering and cycle.First National hypnotic drug side effect survey data shows, in clothes
In the used stable patient for waiting chemicals, there are various drug side-effects in more than 50% people, and nearly 70% people has produced bright
Aobvious drug dependence and drug tolerance.
2nd, traditional Chinese patent medicine species
Traditional Chinese patent medicine thing (colleague's Baizi Yangxin Pills, zhusha anshen pills, JIAWEI XIAOYAOWAN etc.) is into square basis in tradition
On, medicinal raw material is directly prepared into the water-bindered pill, honeyed bolus after infiltration, cleaning, drying, cutting, smashing, or is extracted by water, ethanol
Concentrated extract spraying drying powder-forming is formed, the oral formulations such as hard shell capsules, piece, dripping pill, particle, oral liquid are made.This kind of medicine
Common feature is：(1) active ingredient of medicine is imprecise；(2) the necessary active ingredient of some in raw material can not be extracted；
(3) material effective component purification degree is inadequate；(4) work slow, curative effect is not obvious.
3rd, healthcare food
Nearly 20 years, improve the health food of sleep in China market, more than 95% using epiphysin as raw material, mainstream product
" melatonin ".Country defends planning commission (the former Ministry of Public Health) has clear stipulaties to the edible crowd of epiphysin class health food：Must be 40
Year above adult.Teenager, pregnancy women, Patients with Cardiovascular/Cerebrovascular Diseases, hepatic and kidney function obstacle person and alcohol intolerance person are not
Preferably take.European Countries have carried out strict limitation to taking epiphysin.Germany demonstrates epiphysin to reproduction by zoopery
Function has obvious inhibitory action.The research of Jew of U.S. medical research center shows that epiphysin causes releasing for proinflammatory disease chemicals
Put, this is the mark of asthma, point out asthma patient to avoid using epiphysin.
The content of the invention
It is an object of the invention to solve above problems of the prior art, there is provided a kind of plant with integration of drinking and medicinal herbs
For raw material, treatment and improve insomnia effect significantly, have no toxic side effect, no dependence, without tolerance, take safety, be applicable crowd
Extensively, it is adapted to the treatment of long-term taking and improves composition of insomnia and its production and use.
The purpose of the present invention is achieved through the following technical solutions：
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
10-80 parts, 10-80 parts of cloves, 10-80 parts of nutmeg, 10-80 parts of black pepper, 10-80 parts of Chinese cassia tree.
Further, the composition is made up of the component of following parts by weight：20-70 parts of spina date seed, cloves 20-70
Part, 20-70 parts of nutmeg, 20-70 parts of black pepper, 20-70 parts of Chinese cassia tree.
Further, the formulation of the composition is peroral dosage form.
Further, the peroral dosage form is soft capsule, hard capsule, film coating tablet or drops.
A kind of preparation method for the composition treated and improve insomnia, comprises the following steps：
A. pre-process：Spina date seed, cloves, nutmeg, black pepper, Chinese cassia tree are weighed according to part by weight mix crushing obtain
Grain；
B. carbon dioxide supercritical extraction：The particle is passed through into carbon dioxide supercritical extraction, ultraviolet radiation sterilization
After obtain extract.
Further, the preparation method of the composition of described treatment and improvement insomnia, before the step B is carried out,
The particle is crossed into 20 mesh sieves.
Further, the preparation method of the composition of described treatment and improvement insomnia, the carbon dioxide described in step B
The extracting pressure of supercritical extract is 25Mpa-35Mpa, and extraction temperature is 40 DEG C -50 DEG C, and extraction time is 3h-4h.
Further, the step B also includes the extract oral soft capsule, hard capsule, film coating is made
Tablet or drops.
The composition for the treatment of and improvement insomnia is used for medicine, health food or the functional food for preparing treatment and improvement insomnia
Purposes.
The present invention is relative to the beneficial effect of prior art：
The present invention defends spina date seed, cloves, nutmeg, the black Hu of integration of drinking and medicinal herbs as defined in planning commission (the former Ministry of Public Health) from country
Green pepper, Chinese cassia tree are raw material, using advanced carbon dioxide supercritical extraction technology, fully extract the active ingredient in raw material, nontoxic
Side effect, no dependence, without tolerance, take safety, treatment and improve insomnia effect significantly, be applicable crowd extensively, be applicable length
Phase takes.And avoid what toxic side effect, drug dependence and the tolerance of existing treatment insomnia chemicals were caused to human body
Grievous injury；The active ingredient for avoiding traditional Chinese patent medicine presence is imprecise, and extraction process can not be extracted in material effective component
Liposoluble position, work slow, the unconspicuous problem of therapeutic effect；The health food using epiphysin as raw material is avoided to people's reproduction
The serious consequence that function and asthma patient are caused, the various drawbacks that edible crowd is limited.It is adapted to prepare treatment and improves insomnia
The purposes of medicine or health food.
Embodiment
Following embodiment is of the invention in order to enable those skilled in the art to sufficiently complete understanding, but can not
Therefore it is interpreted as any limitation to the scope of the claims of the present invention.It should be noted that following is only being preferable to carry out for the present invention
Mode, for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some changes
Shape and improvement, these belong to protection scope of the present invention.
First, treating and improve the extract of insomnia composition is used to prepare treatment and improves the medicine of insomnia, health food
Or the purposes of functional food
In the present composition fat oil of spina date seed have it is calm, calm the nerves, hypnosis effect；The eugenol of cloves has town
Quiet, anticonvulsion effect；Myristic grease has sleeping, extension deep sleep time effect；Black pepper oil has anticonvulsion, town
Quiet, analgesic efficacy；The volatile oil of Chinese cassia tree can reduce the spontaneous activity in sleep, calm, extension deep sleep.The present invention is according to the traditional Chinese medical science
Medicine " monarch " is theoretical and Tibetan medicine and pharmacology " theory of three types of disease causes " (imperial, the red bar of section, Baconic) is theoretical.By modern plants biology, medicine
The multi-disciplinary experiment such as thing chemistry, analysis, demonstration.From dialectical treatmert, recuperate under medical treatment, nurse one's health, adjusting, comprehensive effect of taking good care of oneself is used
Row product prescription, complete, scientific evidence is abundant comprehensively for prescription theory, the rigorous refining of compatibility, effect are definitely notable.The present invention is prominent
The characteristics of and advantage be to possess the close composition of numerous chemical constitutions, form corresponding with the effective part group human body of active component and lose
The polymorphism of dormancy, the effect for the treatment of is played altogether and improves insomnia.
Disease prevention and control center's safety toxicology that present composition extract defends planning commission's identification through country is tested
As a result show：Its mouse oral acute toxicity test belongs to nontoxic level；Mutagenicity is had no through genetoxic detection；30 days feeding trials
Visual animal well-grown, figure is active, has no that poisoning symptom and death occurs in animal；Blood biochemical detects only visible male mouse flesh
Acid anhydride is decreased obviously and female mice albumin is significantly raised；Histopathologic examination has no that toxic injury changes.
Improve sleep Experiment on Function result to show：Visual animal well-grown after continuous 14 days nutrition purposes, especially for feeding animals, can significantly prolong
The long yellow Jackets inducing mouse length of one's sleep and the sleep incidence that can increase the induction of amobarbital sub-threshold dose, as a result show
There is the effect for improving sleep to animal.
Hygienic Index is examined and stability test is all qualified.
2nd, medicine is constituted
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
10-80 parts, 10-80 parts of cloves, 10-80 parts of nutmeg, 10-80 parts of black pepper, 10-80 parts of Chinese cassia tree.
In order to reach more preferable therapeutic effect, further optimization each component is as follows：
Further, the composition is made up of the component of following parts by weight：20-70 parts of spina date seed, cloves 20-70
Part, 20-70 parts of nutmeg, 20-70 parts of black pepper, 20-70 parts of Chinese cassia tree.
3rd, application method
The formulation of the extract for the treatment of and improvement the insomnia composition is the oral of medicine, health food or functional food
Formulation.
Soft capsule, hard capsule, film coating tablet is made in the treatment and the extract for improving insomnia composition
Or drops.
A kind of preparation method treated and improve insomnia composition, comprises the following steps：
A, pretreatment：According to part by weight weigh spina date seed, cloves, nutmeg, black pepper, Chinese cassia tree mix crushed 20 mesh
Sieve obtains particle；
B, carbon dioxide supercritical extraction：The particle is passed through into carbon dioxide supercritical extraction, ultraviolet radiation sterilization
Obtain extract；The extracting pressure of carbon dioxide supercritical extraction is 25Mpa-35Mpa, and extraction temperature is 40 DEG C -50 DEG C, extraction
Time is 3h-4h；Oral soft capsule, hard capsule, film coating tablet or drops is made in the extract of composition.
4th, embodiment
Embodiment 1
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
10 parts, 10 parts of cloves, 10 parts of nutmeg, 10 parts of black pepper, 10 parts of Chinese cassia tree.
By the extract of the composition as steps described below, oral soft capsule is made, comprises the following steps that：
1st, by edible gelatin, glycerine and pure water dispensing glue in proportion, dynamic viscosity is detected.
2nd, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Take thing and edible oil to stir in proportion, detect functional component content.
3rd, by specification standards pill, pill weight variation is detected.
4th, shape, wash ball, drying, polish, select ball.
5th, by packing specification it is aluminum-plastic packaged or bottling.
1-5 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 2
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
80 parts, 80 parts of cloves, 80 parts of nutmeg, 80 parts of black pepper, 80 parts of Chinese cassia tree.
By the extract of the composition as steps described below, oral hard capsule is made, comprises the following steps that：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Thing is taken to be wrapped up with cyclodextrine.
2nd, capsule is filled by specification standards, detects pill weight variation.
3rd, by packing specification it is aluminum-plastic packaged or bottling.
1-3 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 3
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
20 parts, 20 parts of cloves, 15 parts of nutmeg, 15 parts of black pepper, 20 parts of Chinese cassia tree.
By the extract of the composition as steps described below, oral hard capsule is made, comprises the following steps that：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Thing is taken to be wrapped up with cyclodextrine.
2nd, capsule is filled by specification standards, detects pill weight variation.
3rd, by packing specification it is aluminum-plastic packaged or bottling.
1-3 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 4
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
20 parts, 20 parts of cloves, 20 parts of nutmeg, 20 parts of black pepper, 20 parts of Chinese cassia tree.
By the extract of the composition as steps described below, oral soft capsule is made, comprises the following steps that：
1st, by edible gelatin, glycerine and pure water dispensing glue in proportion, dynamic viscosity is detected.
2nd, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Take thing and edible oil to stir in proportion, detect functional component content.
3rd, by specification standards pill, pill weight variation is detected.
4th, shape, wash ball, drying, polish, select ball.
5th, by packing specification it is aluminum-plastic packaged or bottling.
1-5 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 5
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
70 parts, 70 parts of cloves, 70 parts of nutmeg, 70 parts of black pepper, 70 parts of Chinese cassia tree.
By the extract of the composition as steps described below, oral film coating tablet is made, comprises the following steps that：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Thing is taken to be wrapped up with cyclodextrine.
2nd, by piece weight-normality lattice tabletting, tablet weight variation is detected.
3rd, film coating.
4th, by packing specification it is aluminum-plastic packaged or bottling.
1-4 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 6
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
30 parts, 10 parts of cloves, 10 parts of nutmeg, 20 parts of black pepper, 30 parts of Chinese cassia tree.
Soft capsule, hard capsule, film coating tablet or drops is made in the extract of the composition.
Or, Oral drops are made by the extract of the composition as steps described below, comprise the following steps that：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Take thing and edible oil to stir in proportion, detect functional component content.
2nd, it is filling by filling specification, detect content uniformity.
1-2 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 7
A kind of composition treated and improve insomnia, the Chinese medicine composition is made up of the component of following parts by weight：Acid
10 parts of jujube kernel, 20 parts of cloves, 30 parts of nutmeg, 30 parts of black pepper, 10 parts of Chinese cassia tree.
Soft capsule, hard capsule, film coating tablet or drops is made in the extract of the composition.
Or, oral soft capsule is made by the extract of the composition as steps described below, comprise the following steps that：
1st, by edible gelatin, glycerine and pure water dispensing glue in proportion, dynamic viscosity is detected.
2nd, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Take thing and edible oil to stir in proportion, detect functional component content.
3rd, by specification standards pill, pill weight variation is detected.
4th, shape, wash ball, drying, polish, select ball.
5th, by packing specification it is aluminum-plastic packaged or bottling.
1-5 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 8
It is a kind of treat and improve insomnia Chinese medicine composition, the Chinese medicine composition by following parts by weight component group
Into：30 parts of spina date seed, 30 parts of cloves, 30 parts of nutmeg, 15 parts of black pepper, 15 parts of Chinese cassia tree.
Soft capsule, hard capsule, film coating tablet or drops is made in the extract of the composition.
Or, oral hard capsule is made by the extract of the composition as steps described below, comprise the following steps that：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Thing is taken to be wrapped up with cyclodextrine.
2nd, capsule is filled by specification standards, detects pill weight variation.
3rd, by packing specification it is aluminum-plastic packaged or bottling.
1-3 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 9
A kind of composition treated and improve insomnia, the Chinese medicine composition is made up of the component of following parts by weight：Acid
60 parts of jujube kernel, 10 parts of cloves, 10 parts of nutmeg, 10 parts of black pepper, 10 parts of Chinese cassia tree.
Soft capsule, hard capsule, film coating tablet or drops is made in the extract of the composition.
Or, oral film coating tablet is made, comprises the following steps that by the extract of the composition as steps described below：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Thing is taken to be wrapped up with cyclodextrine.
2nd, by piece weight-normality lattice tabletting, tablet weight variation is detected.
3rd, film coating.
4th, by packing specification it is aluminum-plastic packaged or bottling.
1-4 step workshop environmental requirements：100,000 grades of air purity.
Embodiment 10
A kind of composition treated and improve insomnia, the composition is made up of the component of following parts by weight：Spina date seed
10 parts, 10 parts of cloves, 10 parts of nutmeg, 10 parts of black pepper, 80 parts of Chinese cassia tree.
Soft capsule, hard capsule, film coating tablet or drops is made in the extract of the composition.
Or, Oral drops are made by the extract of the composition as steps described below, comprise the following steps that：
1st, by according to the extraction of the composition for the treatment of of the present invention and the composition for improving insomnia and preparation method thereof gained
Take thing and edible oil to stir in proportion, detect functional component content.
2nd, it is filling by filling specification, detect content uniformity.
1-2 step workshop environmental requirements：100,000 grades of air purity.
Technical scheme can preferably be realized according to the record of this specification.
Claims (9)
1. it is a kind of treat and improve insomnia composition, it is characterised in that the composition by following parts by weight component group
Into：10-80 parts of spina date seed, 10-80 parts of cloves, 10-80 parts of nutmeg, 10-80 parts of black pepper, 10-80 parts of Chinese cassia tree.
2. treatment according to claim 1 and the composition of improvement insomnia, it is characterised in that the composition by weighing as follows
Measure the component composition of number：20-70 parts of spina date seed, 20-70 parts of cloves, 20-70 parts of nutmeg, 20-70 parts of black pepper, Chinese cassia tree
20-70 parts.
3. treatment according to claim 1 or 2 and the composition of improvement insomnia, it is characterised in that the agent of the composition
Type is peroral dosage form.
4. treatment according to claim 3 and the composition of improvement insomnia, it is characterised in that the peroral dosage form is flexible glue
Wafer, hard capsule, film coating tablet or drops.
5. a kind for the treatment of of claim 1 or 2 and the preparation method for improving the composition having a sleepless night, it is characterised in that including as follows
Step：
A. pre-process：According to part by weight weigh spina date seed, cloves, nutmeg, black pepper, Chinese cassia tree mix crushing obtain particle；
B. carbon dioxide supercritical extraction：The particle is obtained after carbon dioxide supercritical extraction, ultraviolet radiation sterilization
To extract.
6. treatment according to claim 5 and the preparation method for the composition for improving insomnia, it is characterised in that carrying out institute
State before step B, the particle is crossed into 20 mesh sieves.
7. treatment according to claim 6 and the preparation method for the composition for improving insomnia, it is characterised in that in step B
The extracting pressure of described carbon dioxide supercritical extraction is 25Mpa-35Mpa, and extraction temperature is 40 DEG C -50 DEG C, extraction time
For 3h-4h.
8. the preparation method of the composition for the treatment of and improvement insomnia according to claim 5 or 7, it is characterised in that described
Step B also includes the extract oral soft capsule, hard capsule, film coating tablet or drops is made.
9. the composition that insomnia was treated and improved to claim 1 or 2 is used to prepare treatment and improves the medicine of insomnia, health food
Or the purposes in functional food.
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| Application Number | Priority Date | Filing Date | Title |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483430A (en) * | 2002-09-19 | 2004-03-24 | 中国科学院西北高原生物研究所 | Health care medicinal composition for improving sleeping and preparation preocess thereof |
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2017
- 2017-04-25 CN CN201710278143.2A patent/CN107007666A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483430A (en) * | 2002-09-19 | 2004-03-24 | 中国科学院西北高原生物研究所 | Health care medicinal composition for improving sleeping and preparation preocess thereof |
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Application publication date: 20170804 |