CN105688070A

CN105688070A - Medicine composition for treating postpartum depression

Info

Publication number: CN105688070A
Application number: CN201610159883.XA
Authority: CN
Inventors: 陈霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-14
Filing date: 2016-03-14
Publication date: 2016-06-22

Abstract

The invention relates to a medicine composition for treating postpartum depression. The medicine composition is prepared from rhizoma acori graminei, dwarf lilyturf roots, rhizoma ligustici wallichii, poria cocos, wild jujube seeds, fruit of Chinese magnoliavine, radix salviae miltiorrhizae, radix curcumae, pericarpium citri reticulatae, fructus aurantii, polygala tenuifolia, liquorice roots, herba menthae and flos chrysanthemi. The medicine composition has a good effect for treating postpartum depression, and the untoward effect is less than that of common antidepressant of western medicine.

Description

A kind of pharmaceutical composition treating postpartum depression

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of pharmaceutical composition for treating postpartum depression。

Background technology

Postpartum depression is puerpera with the low mood disorders for principal character of mental state。Primary disease sickness rate is higher, and along with socioeconomic development presents the trend continuing to raise。Postpartum depression not only has a strong impact on the physical and mental health of puerpera, and affects development and the family harmony of the emotion of baby, intelligence and behavior。Postpartum depression can develop into major depression, hallucination, autotomy occurs, commits suiside or infanticide, and it is even lifelong that the course of disease can delay several months to the several years。Therefore, the clinical intervention that the needs of patients of postpartum depression is positive, to alleviate or to eliminate postpartum depression symptom as early as possible and to reduce the risk of recurrence。At present that the Study of Etiology of postpartum depression is not yet clear and definite, therefore there is no unified therapeutic scheme clinically。

Summary of the invention

The goal of the invention of the present invention is to provide a kind of Chinese medicine composition treating postpartum depression, to solve the problem that existing Therapeutic Method is imprecise and side effect is big。

The pharmaceutical composition of the present invention is by weight ratio: Rhizoma Acori Graminei, Radix Ophiopogonis, Rhizoma Chuanxiong, Poria, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Curcumae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Polygalae, Radix Glycyrrhizae, Herba Menthae, Flos Chrysanthemi。

The pharmaceutical composition of the present invention is by weight ratio: Rhizoma Acori Graminei 25 parts, Radix Ophiopogonis 25 parts, Rhizoma Chuanxiong 25 parts, 20 parts of Poria, Semen Ziziphi Spinosae 20 parts, Fructus Schisandrae Chinensis 20 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Curcumae 20 parts, Pericarpium Citri Reticulatae 18 parts, Fructus Aurantii 18 parts, Radix Polygalae 15 parts, 15 parts of Radix Glycyrrhizae, Herba Menthae 15 parts, Flos Chrysanthemi 15 parts。

The preparation method of above pharmaceutical composition is: take the mixing of above pharmaceutical composition crude drug, it is ground into 10～20 order coarse granules, add 60% ethanol 6 times (volume), extracting three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, and clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, adds proper auxiliary materials, makes corresponding dosage form。

Adjuvant in the present invention can be acceptable any excipient or carrier on pharmaceutics。

Rhizoma Acori Graminei: have one's ideas straightened out, allay excitement, removing dampness to restore normal function of the stomach。Modern pharmacy research proves, Rhizoma Acori Graminei has the effects such as calmness, cooling, spasmolytic, antifungal。

Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire。Modern pharmacy research proves, Radix Ophiopogonis containing multiple steroid saponin, Radix Ophiopogonis Saponin A, B, C, D, glycoside unit is ruscogenin, separately containing ophiopogonin B ', C ', D ', glycoside unit is diosgenin；Still containing multiple flavone compound, as Radix Ophiopogonis methyl yellow alkanone A, B, Radix Ophiopogonis flavanone A, ophiopogonone A, B, methyl ophiopogonone A, B etc., have calmness, improve immunity, fatigue-resisting function。

Rhizoma Chuanxiong: blood circulation promoting and blood stasis dispelling, wind-expelling pain-stopping。Modern pharmacy research proves, Chuanxiong bioalkali, ferulic acid and cnidium lactone have spasmolysis, and ligustilide is then the main component of spasmolytic, and large intestine, dysentery (Song Nei Shi), deformation, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc. are had inhibitory action。Some pathogenic dermatophytes is in vitro also had inhibitory action by Rhizoma Chuanxiong water logging agent (1: 3)。Having obvious analgesic activity, sodium ferulate can reduce H₂O₂And O₂The lipid peroxidation caused, has oh resistant and the effect of malonaldehyde (MDA) haemolysis。Sodium ferulate can obviously reduce complement hemolysis, it is suppressed that the combination of complement component 3 b (C36) and erythrocyte membrane。

Poria: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming。Modern pharmacy research proves, Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect。

Semen Ziziphi Spinosae: tranquilizing by nourishing the heart, tonifying YIN arresting sweating。Modern pharmacy research proves, Semen Ziziphi Spinosae has the effects such as calmness, hypnosis, stable, analgesia。

Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming。Modern pharmacy research proves, schisandrol extract can reduce the laboratory animal glutamate pyruvate transaminase that caused by carbon tetrachloride, thioethanolamine etc. and raise. and wuweizisu B (schisandrin B) has anti-liver injury effect, also has stable, heart tonifying, enhancing immunity, the effect such as antibacterial。

Radix Salviae Miltiorrhizae: nourishing blood to tranquillize the mind, blood circulation promoting and blood stasis dispelling。Modern pharmacy research proves, Radix Salviae Miltiorrhizae contains TANSHINONES, salvianolic acid, flavone, the material such as triterpene, sterol, can strengthen myocardial contraction, improve cardiac function, does not increase myocardial oxygen consumption。

Radix Curcumae: regulating qi to disperse stagnation, heart fire-clearing upset-relieving。Modern pharmacy research proves, Radix Curcumae is containing volatile oil, wherein there are camphene, Camphora, curcumene, also containing curcumin, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone, still contain starch, fatty oil, rubber, weld, Eucarvone and phellandrene etc., there is the effects such as antifungal。

Pericarpium Citri Reticulatae: in regulating qi-flowing for strengthening spleen, tune。Modern pharmacy research proves that gastrointestinal tract is had the stimulation of gentleness by volatile oil contained by Pericarpium Citri Reticulatae, can the secretion of facilitating digestion liquid, get rid of pneumatosis in intestinal tube, also there is the effect such as defying age, antioxidation。

Fructus Aurantii: dispelling the stagnated QI, row expectorant, removing food stagnancy。Modern pharmacy research proves, Fructus Aurantii has the effect of antiallergic action。

Radix Polygalae: Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subside a swelling。Modern pharmacy research proves, Radix Polygalae have eliminate the phlegm, calmness, the effect such as analgesia。

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription。Modern pharmacy research proves, Radix Glycyrrhizae has antiinflammatory, antiallergic action, antianaphylactic effect, and licoflavone, Radix Glycyrrhizae extractum and enoxolone all have obvious antitussive effect。

Herba Menthae: wind-dispelling heat-dissipating, refresh oneself, throat。Modern pharmacy research proves, Herba Menthae contains menthol, and this material has antipruritic, pain relieving, anticorrosion, stimulation, anesthesia, refrigerant and antiinflammatory action。

Flos Chrysanthemi: dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight。Modern pharmacy research proves, Flos Chrysanthemi has the effect of antiviral, and foreign study scholar finds, herpes simplex virus poliovirus and Measles virus are had inhibitory action in various degree by Flos Chrysanthemi。Additionally, also have the effect such as antiinflammatory, antitumor。

In order to show that postpartum depression is had good therapeutic effect by the present invention, carry out following clinical trial:

1. data and method

1.1 physical data: my institute's department of obstetrics and gynecology Hospitalized puerpera in June ,-2015 in June, 2014, wherein 52 example patients with postpartum depression, age 19-42 year, average 25.3 years old。It is divided into two groups according to Therapeutic Method different random, western medicine group 26 example, treatment by Chinese herbs group 26 example。

1.2 diagnostic criterias: with reference to the 7th edition " obstetrics and gynecology ", the standard of the Puerperous Depression that Americanism association formulates at " diagnostic & statistical manual of mental sickness "。There is the symptom of following 5 or more than 5 of appearance in 2 weeks puerperal。(must possess 1. 2. two) is 1. in a very depressed state；2. whole or most activities are substantially lacked interest or joyful；3. body weight is remarkably decreased or increases；4. insomnia or hypersomnia；5. psychomotor excitement or sluggishness；6. tired or weak；7. all feel meaningless when anything crops up or have inferiority complex；8. thinking ability goes down or absent minded；9. idea that is dead or that commit suiside occurs repeatedly。Fell ill within 4 weeks puerperal。

1.3 Therapeutic Method: Western medicine group: with serotonin reuptake inhibithors fluoxetine or tricyclic antidepressant amitriptyline。4～6 weeks medicine times are not etc.。Chinese drug-treated group: the embodiment of the present invention 1 granule, each two bags, every day three times, the course for the treatment of is 4～6 weeks。

1.4 curative effects are passed judgment on

Each patient is evaluated curative effect by improvement degree average after the treatment of 9 symptoms of primary disease diagnostic criteria。Each severe symptom 2 points, the lighter 1 point, symptom without or disappearance person 0 point。After treatment, total score reduces by more than 6 points persons is effective, reduces 3～5 and is divided into effectively, and reducing by 0～2 point of person is DeGrain。The average mark that after contrasting two groups of patient, symptom is improved。With statistical method comparing difference significance。And record frequency and degree that relevant Drug side reaction occurs。

2. result

2.1 comparitive study:

Western medicine group effect shows author 12 example, responder 8 example, DeGrain person 6 example。

Chinese drug-treated group effect shows author 13 example, responder 8 example, DeGrain person 5 example。

Statistical analysis, two groups of curative effect no difference of science of statistics。

2.2 adverse effectes:

In Western medicine group, 9 examples occur that side effect is lassitude on daytime, drowsiness, account for 34.62%。

In Chinese drug-treated group 26 example, without lethargy and drowsiness person on daytime occurs。

Clinical trial shows that medicine of the present invention has the effect of good treatment postpartum depression, similar with Western medicine fluoxetine or amitriptyline effect on the whole, but there is no obvious adverse reaction。Antidepressant fluoxetine or amitriptyline that Chinese medicine preparation of the present invention is better than commonly using are described。

Specific embodiment

Embodiment 1 Rhizoma Acori Graminei 25g, Radix Ophiopogonis 25g, Rhizoma Chuanxiong 25g, Poria 20g, Semen Ziziphi Spinosae 20g, Fructus Schisandrae Chinensis 20g, Radix Salviae Miltiorrhizae 20g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 18g, Fructus Aurantii 18g, Radix Polygalae 15g, Radix Glycyrrhizae 15g, Herba Menthae 15g, Flos Chrysanthemi 15g

The preparation method of granule of the present invention: take the mixing of above pharmaceutical composition crude drug, it is ground into 10～20 order coarse granules, add 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, adds amylum pregelatinisatum 500g, sodium carboxymethyl cellulose 250g, mixed 80 mesh sieves, adds suitable quantity of water and granulates, 60 DEG C of drying under reduced pressure, granulate, is distributed into 100 bags, to obtain final product。

Embodiment 2 Rhizoma Acori Graminei 25g, Radix Ophiopogonis 25g, Rhizoma Chuanxiong 25g, Poria 20g, Semen Ziziphi Spinosae 20g, Fructus Schisandrae Chinensis 20g, Radix Salviae Miltiorrhizae 20g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 18g, Fructus Aurantii 18g, Radix Polygalae 15g, Radix Glycyrrhizae 15g, Herba Menthae 15g, Flos Chrysanthemi 15g

The preparation method of hard capsule of the present invention: take the mixing of above pharmaceutical composition crude drug, it is ground into 10～20 order coarse granules, add 60% ethanol 6 times (volume), extracting three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, and clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, loads capsule, to obtain final product。

Embodiment 3 Rhizoma Acori Graminei 25g, Radix Ophiopogonis 25g, Rhizoma Chuanxiong 25g, Poria 20g, Semen Ziziphi Spinosae 20g, Fructus Schisandrae Chinensis 20g, Radix Salviae Miltiorrhizae 20g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 18g, Fructus Aurantii 18g, Radix Polygalae 15g, Radix Glycyrrhizae 15g, Herba Menthae 15g, Flos Chrysanthemi 15g

The preparation method of Tablets: take the mixing of above pharmaceutical composition crude drug, be ground into 10～20 order coarse granules, add 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, and clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, add starch, Pulvis Talci and Magnesium Stearate proper quantity, granulate, tabletted, coating, to obtain final product。

Claims

1. the Chinese medicine composition treating postpartum depression, it is characterised in that the raw material making this pharmaceutical composition active component is: Rhizoma Acori Graminei, Radix Ophiopogonis, Rhizoma Chuanxiong, Poria, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Curcumae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Polygalae, Radix Glycyrrhizae, Herba Menthae, Flos Chrysanthemi。

2. Chinese medicine composition as claimed in claim 1, it is characterized in that in parts by weight, the raw material making this pharmaceutical composition active component is: Rhizoma Acori Graminei 25 parts, Radix Ophiopogonis 25 parts, Rhizoma Chuanxiong 25 parts, 20 parts of Poria, Semen Ziziphi Spinosae 20 parts, Fructus Schisandrae Chinensis 20 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Curcumae 20 parts, Pericarpium Citri Reticulatae 18 parts, Fructus Aurantii 18 parts, Radix Polygalae 15 parts, 15 parts of Radix Glycyrrhizae, Herba Menthae 15 parts, Flos Chrysanthemi 15 parts。

3. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that it is granule, tablet or capsule。

4. Chinese medicine composition as claimed in claim 3, it is characterized in that method for making is as follows: take the mixing of described pharmaceutical composition crude drug, it is ground into 10～20 order coarse granules, adds 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, and dried cream powder is broken, add proper auxiliary materials, make corresponding dosage form。

5. Chinese medicine composition as claimed in claim 4, it is characterized in that method for making is as follows: take Rhizoma Acori Graminei 25g, Radix Ophiopogonis 25g, Rhizoma Chuanxiong 25g, Poria 20g, Semen Ziziphi Spinosae 20g, Fructus Schisandrae Chinensis 20g, Radix Salviae Miltiorrhizae 20g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 18g, Fructus Aurantii 18g, Radix Polygalae 15g, Radix Glycyrrhizae 15g, Herba Menthae 15g, Flos Chrysanthemi 15g, mixing, it is ground into 10～20 order coarse granules, add 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, add amylum pregelatinisatum 500g, sodium carboxymethyl cellulose 250g, mixed 80 mesh sieves, add suitable quantity of water to granulate, 60 DEG C of drying under reduced pressure, granulate, it is distributed into 100 bags。