CN108371682A - A kind of drug for treating constipation and preparation method thereof and purposes - Google Patents
A kind of drug for treating constipation and preparation method thereof and purposes Download PDFInfo
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- CN108371682A CN108371682A CN201810380130.0A CN201810380130A CN108371682A CN 108371682 A CN108371682 A CN 108371682A CN 201810380130 A CN201810380130 A CN 201810380130A CN 108371682 A CN108371682 A CN 108371682A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to the field of Chinese medicines, in particular to a kind of drug for treating constipation and preparation method thereof and purposes.The drug includes the material component of following proportioning：2~8 parts by weight of 10~17 parts by weight of chrysanthemum, 1~6 parts by weight of potentilla discolor and matrimony vine.The drug can effectively treat constipation, without apparent toxicity.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of drug for treating constipation and preparation method thereof and purposes.
Background technology
As society continues to develop, survival pressure further increases, and increasingly competitive and ingesta structure etc. is no
It is disconnected to change, cause constipation illness rate to gradually increase.It is shown according to the related epidemiological investigation data in the U.S., in the U.S.,
The incidence of constipation is 2%, and several National sex investigations are shown, the age ratio of more great trouble constipation disease is higher.It consults
The relevant epidemiologic survey report of the related constipation of China shows that the constipation incidence in China is 6.07%, in China's constipation
Incidence influenced by provincialism, show regional disparity, but the incidence of the disease is all higher than 2%.Elderly population even
It can reach 15%~20%.Constipation symptom is obstinate, makes patient suffering endlessly, seriously affects the quality of life of broad masses of the people,
Multiple complications can also be generated.But also it is the risk factor of the disease such as alzheimer's disease, hepatic encephalopathy.Even acute myocardial infarction or brain
Blood vessel can surprisingly be induced because of constipation, and patient vitals are directly on the hazard.
Ancient Times in China doctor is more to the classification of constipation, such as《The Treatise on Fevrile Diseases》Constipation is divided into " yin constipation ", " yang constipation ", " spleen
About ", " Tianjin exhausts " etc.；Later age doctor be divided into again wind is secret, gas is secret, it is wet it is secret, it is cold it is secret, heat is secret, constipation due to endogenous cold, empty secret, hot dry, wind-dryness.Afterwards
Again because vertical name is too numerous, and constipation is divided into yin constipation and yang constipation to summarize:It is yang constipation to have fiery person, and no fiery person is yin constipation.It is either cloudy
Knot or yang constipation are all because intestinal environment is lacked of proper care, caused by viscera function exception.Constipation can be divided into secondary constipation and primary
Property constipation.Constipation of slow-remove type is main one kind in primary functional consitipation, and incidence accounts for about entire constipation patient
45.5%.It is abundant for the treatment motherland medical practice of constipation, more show significant advantage in terms of preventing constipation of slow-remove type,
And Small side effects, curative for effect etc..
Medicine type about constipation is various, but most of drug initial stage is preferable using curative effect by clinic application, but
With the extension of usage time, effect is more and more unsatisfactory, and drug side-effect Probability also greatly increases therewith.Also occur
Medication is diarrhea, the drug dependence for i.e. constipation of being discontinued.Therefore the sufferings of prolonged constipation patient how are enable to mitigate, by constipation
Caused adverse consequences is reduced, and effectively treats constipation, this vital task is put in face of numerous medical personnels.
The prescription of Chinese traditional treatment constipation is various, and the specific aim of each prescription is different, but generally existing formula is complicated, prepares cost height etc. and asks
Topic, thus need further research.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of drug for treating constipation, and the drug has good drug efficacy, without bright
The advantages that aobvious toxicity.
The drug of the treatment constipation of the present invention is made of the raw material of following proportioning：10~17 parts by weight of chrysanthemum, potentilla discolor 1~
2~8 parts by weight of 6 parts by weight and matrimony vine.
The second object of the present invention is to provide the method for preparing drug of the present invention.
In one embodiment, each raw material is crushed, is mixed.
In one embodiment, the method for the present invention includes the following steps：
(a) each starting material with water is decocted, obtains decocting liquid, or extracted with ethanol water, obtains extracting solution；
(b) required dosage form is prepared with the decocting liquid or the extracting solution.
Another aspect of the present invention is related to purposes of the drug of the present invention in preparing the medicament for treating constipation.
Compared with prior art, beneficial effects of the present invention are：
(1) good drug efficacy, pure Chinese medicine formula, without apparent toxicity；
(2) medication in the form of Chinese medicine preparation, convenient to take, effect is good；
(3) constipation can effectively be treated.
Specific implementation mode
One aspect of the present invention is related to treating the drug of constipation, is made of following raw material：Chrysanthemum, potentilla discolor and matrimony vine.
Preferably, drug of the invention is made of the raw material of following proportioning：10~17 parts by weight of chrysanthemum, 1~6 weight of potentilla discolor
Measure part and 2~8 parts by weight of matrimony vine.
Preferably, drug of the invention is made of the raw material of following proportioning：11~16 parts by weight of chrysanthemum, 2~5 weight of potentilla discolor
Measure part and 3~7 parts by weight of matrimony vine.
Preferably, drug of the invention is made of the raw material of following proportioning：12~15 parts by weight of chrysanthemum, 3~4 weight of potentilla discolor
Measure part and 4~6 parts by weight of matrimony vine.
Preferably, drug of the invention is made of the raw material of following proportioning：13~14 parts by weight of chrysanthemum, 3.5 weight of potentilla discolor
Measure part and 5 parts by weight of matrimony vine.
One, raw material (component)
(1) chrysanthemum
Chrysanthemum (scientific name：Chrysanthemum it) is commonly called as chrysanthemum, alias longevity visitor, Jin Ying, Huang Hua, Qiu Ju, Tao Ju etc., are chrysanthemums
A category for mesh composite family herbaceos perennial.There are about 40 kinds under it, wherein most of originate in East Asia, center of divergence exists
China.It is preferred that the tribute chrysanthemum in Mount Huang, the FLOS CHRYSANTHEMI ALBA from Haizhou of China (Chrysanthemum morifolium) of Tongxiang and the wild chrysanthemum in Shandong.Chrysanthemum
Flower includes chrysanthemum glucoside, amino acid, flavonoids and multivitamin and trace element.Traditional medicine thinks, chrysanthemum have nourish the liver to improve visual acuity,
Clear away heart-fire, kidney tonifying, strengthening the spleen and stomach, wet one's whistle, promote the production of body fluid, and adjustment blood fat and other effects.Often drink chrysanthemum tea, can with the spring it is warm dry, summer heat solution
Yearningly, solution dry, winter on autumn days relieves inflammation or internal heat.
(2) potentilla discolor
Potentilla discolor (scientific name：Potentilla discolor) be rose family Potentilla plant.Potentilla discolor alias chicken feet
Pawl, thousand hammerings, Japanese Raspberry Root etc. belong to the rose family.Various regions are produced, raw ripe equal edible, can hyoscine.Root contains Flavonoid substances,
Potentilla discolor is mild-natured, sweet-bitter flavor, nontoxic.Herb contains tannin.There is the effect of clearing heat and detoxicating, stop dysentery hemostasis.
(3) matrimony vine
Matrimony vine (scientific name：Lycium chinense) be Solanaceae Lycium one kind, fruit claims the fruit of Chinese wolfberry, tender leaf to claim matrimony vine
Head.The present invention use be matrimony vine fruit medicine.The fruit of lycium barbarum (L.barbarum) can also be used.Matrimony vine is main
As medicinal and tonic, two kinds of purposes.Matrimony vine alias " son on the sunny side ", the moon of energy filling liver kidney, the red category fire of color mend able-bodied sun.
Preferably, drug as described above, the drug further comprise auxiliary material or excipient.
Two, form and dosage form
In one embodiment, drug of the invention is simple mixtures.Preparation process is by each medicinal material (raw material) letter
Single mixing, this simple mixtures are suitable for decoction.
In another embodiment, drug of the invention can be made into the form of Chinese patent drug.The dosage form packet of Chinese patent drug
Include but be not limited to pill, powder, paste, tablet, granule (electuary), pastille, capsule, aqua, tincture.
(1) pill
Pill is fine medicinal material powder or medicinal substances extract adds suitable binders or auxiliary material, manufactured spherical or spherical solid
Preparation is most ancient one of the dosage form of Chinese patent drug.It is divided into as honeyed bolus, water-honeyed pill, the water-bindered pill, paste according to the different pills of adhesive
The types such as ball, condensed pill, pellet.
It is preferable to use condensed pills.Condensed pill is the decocting liquid or extracting solution of whole medicinal materials or part medicinal material, with suitable auxiliary material
Or fine drug powder adds suitable adhesive to be made.According to the difference of adhesive, it is divided into as concentration honeyed bolus, the concentration water-bindered pill, condensed water
Honeyed bolus.Condensed pill is small, and effective ingredient content is high, is easy to take, and it is slower to dissolve absorption in vivo.
In a preferred embodiment, by whole medicinal materials or the decocting liquid or extracting solution of part medicinal material, with auxiliary material or medicine
Object fine powder adds adhesive that condensed pill is made.Preferably, by whole medicinal material decocting liquids or extracting solution and adhesive and optional auxiliary material system
At condensed pill.
(2) powder
Powder is the powder preparation that one or more medicinal materials are mixed, and divides oral powder and external pulvis, is China
One of ancient times dosage form.Powder therapeutic domain is wide, disperses soon, to prove effective rapid after taking, and with easy to make, easy to carry, section
The advantages that saving medicinal material.
(3) paste
One of paste system pharmaceutical dosage form.Paste is that drug water or vegetable oil are decocted dosage form made of concentration.Have for oral administration
With two kinds of external application.Cream for oral administration is usually divided into liquid extract, medicinal extract, three kinds of soft extracts；External plaster has two kinds of ointment, plaster.It is wherein for oral administration
Soft extracts and externally-applied ointment are common dosage forms in paste.Soft extracts for oral administration is called cream taste, is to add decocting to endure drug, filters dregs, adds
Enter rock sugar, honey etc., be boiled into the cream of stiff, can take for a long time.It is usually used in chronic disease or person in poor health.The ointment of external application claims
Ointment, general ointment are that beeswax is added in cotton seed oil or peanut oil, and heating fusing multiplies the fine drug powder that application is added in heat, no
Disconnected stirring, to be condensed.The readily volatilized medicine such as borneol, camphor can be added after ointment is cold and stir evenly.External-applied ointment is generally used
In outer painting skin ulcer mange etc..
For the medicament for the treatment of hemorrhoid provided by the present invention, it is preferred to use the form of ointment for oral administration.
(4) tablet
Tablet is fine medicinal material powder or extract and Formulation, sub-dip cream made of suitable auxiliary material or fine medicinal material powder compacting
Piece, semi-extract tablets and full powder piece etc., are one of common modern formulations.Tablet volume is small, and dosage is accurate, and easy disintegrating comes into force soon,
And have the advantages that production efficiency it is high, it is at low cost, take and storage and transportation is convenient.Tablet is suitable for various diseases.The present invention preferably makes
With medicinal extract piece.
(5) granule
Granule (electuary) be medicinal substances extract with suitable auxiliary material or with granular formulations made of fine medicinal material powder, be
The novel form to grow up on the basis of decoction, powder and syrup.There are two kinds of graininess and bulk, is divided into soluble, suspension
The different types such as property, effervescency and sugar-containing type, Sugarless type.Granule is small, light-weight, takes simply, and in good taste, effect is fast
Speed, the drug for the effects that being chiefly used in help, cough-relieving, heat-clearing.
Preferably, it is prepared using water extract (decocting liquid) when preparation.
(6) pastille
Pastille is that regulation shape is made with suitable amount of adhesive such as honey, glutinous rice flour or the viscosity using medicinal material itself in fine medicinal material powder
The solid pharmaceutical preparation of shape.It for for oral administration or external application, takes effect orally and is approached with starched pill, external application applies affected part after being mostly used water or vinegar mill juice.
Holding in the mouth or the eyes is used pastille type mostly.
Preferably, pastille of the invention is pastille for oral administration.
(7) capsule
Capsule includes hard capsule and soft capsule.
Hard capsule be by suitable medicinal substances extract, medicinal substances extract dosing powder or auxiliary material be made uniform powder or
Grain, is filled in hard capsule and manufactured dosage form.It is mainly oral.Hard capsule appearance is neat and artistic, is easy to swallow, and can cover medicine
The bad odor of object, disintegration is fast, good absorbing.Suitable for light sensitive, unstable or wet, thermally labile the drug of chance, or there is spy
The drug of different odor, or need the drug of timing positioning release.Children, the drug strong to gastric irritation should not be made
Capsule.
Soft capsule is by oils or to be closed in capsule material to liquid medicine of the capsule materials such as gelatin without dissolution or suspension
Dosage form made of interior.Feature is similar to hard capsule.Hard capsule and soft capsule handle by proper method or with other medicinal high scores
Sub- material processing, makes softgel shell not dissolve in gastric juice, but be disintegrated discharge active component in intestinal juice, is capsulae enterosolubilis.
Preferably, capsule of the invention is that the medicinal substances extract for obtaining decocting liquid or extracting solution adds auxiliary material that uniform powder is made
End or particle, are filled in hard capsule and manufactured dosage form.
(8) tincture
Tincture is that the ethyl alcohol of drug normal concentration leaches or dissolve manufactured supernatant liquid preparation, can also use liquid extract
Dilution is made.It is divided to for oral administration and two kinds of external application.Tincture is prepared without heating, and ingredient is purer, and active constituent content is high, and dosage is accurate
Really, it absorbs rapidly, is suitable for preparing the preparation containing volatile ingredient or thermo-labile component.Preferably, tincture of the invention is
Tincture for oral administration.
Three, purposes
Another aspect of the present invention is related to purposes of the drug of the present invention in preparing the drug for treating constipation.
Four, preparation method
Another aspect of the present invention is related to treating the preparation method of the drug of constipation.
1, the preparation of simple mixtures
Above-mentioned raw materials can be simply mixed together, to prepare the simple mixtures of the present invention.
In one embodiment, the method for preparing the drug includes the following steps：Each component is crushed, is blended in one
It rises.
Preferably, for ease of use, the method further includes, by the drug packages in medicine bag.
The medicine bag eats grid cloth and prepares, and directly medicine bag can duck in drink, and carries and eats easily.
2, the preparation of Chinese patent drug
In one embodiment, the method for preparing drug of the present invention includes the following steps：
(a) above-mentioned raw materials are decocted with water, obtains decocting liquid, or extracted with ethanol water, obtains extracting solution；
(b) required dosage form is prepared with decocting liquid.
Dosage form can be above-mentioned dosage form, for example, pill, powder, paste, tablet, granule (electuary), pastille, capsule,
Aqua or tincture.
Five, it takes and curative effect explanation：
For simple mixtures, for example, it is one including 13 grams of chrysanthemum, 3.5 grams of potentilla discolor, 5 grams of matrimony vine it is one.Every dose of clothes
It is soaked to take with two days.Defaecation in 1~5 hour after less serious case takes, severe one generally have clear improvement after 24 hours, are within 6 days
One course for the treatment of.
It is of course also possible to take Chinese patent drug dosage form.On the basis of above-mentioned decocting liquid dosage, Chinese patent drug dosage form dose passes through
Clinical trial in the art can determine.
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
It can be with conventional products that are commercially available.
Embodiment 1
14 grams of chrysanthemum, 3.5 grams of potentilla discolor, 5 grams of matrimony vine.
Above-mentioned raw materials are packed using medicine bag, soaked to take, every dose is used in conjunction two days, 6 days as a treatment course.
Embodiment 2
13 grams of chrysanthemum, 3 grams of potentilla discolor, 6 grams of matrimony vine.
It takes as described in Example 1.
Embodiment 3
14 grams of chrysanthemum, 4 grams of potentilla discolor, 4 grams of matrimony vine.
It takes as described in Example 1.
Embodiment 4
15 grams of chrysanthemum, 3 grams of potentilla discolor, 6 grams of matrimony vine.
It takes as described in Example 1.
Embodiment 5
12 grams of chrysanthemum, 4 grams of potentilla discolor, 4 grams of matrimony vine.
It takes as described in Example 1.
Embodiment 6 (aqua)
110 grams of chrysanthemum, 50 grams of potentilla discolor, 30 grams of matrimony vine.
2 liters of drinking water are added and stew boiling 40 minutes, are concentrated into 100mL to get aqua.
Embodiment 7 (condensed pill)
160 grams of chrysanthemum, 20 grams of potentilla discolor, 70 grams of matrimony vine.
2.5 liters of drinking water are added and stew boiling 60 minutes, are then concentrated into paste, make pelletization.
Embodiment 8 (soft extract)
170 grams of chrysanthemum, 60 grams of potentilla discolor, 20 grams of matrimony vine.
1.5 liters of drinking water are added and stew boiling 60 minutes, then concentrate, xylitol is added, soft extract is made.
Embodiment 9 (tablet)
100 grams of chrysanthemum, 60 grams of potentilla discolor, 80 grams of matrimony vine.
1.5 liters of drinking water are added and stew boiling 60 minutes, then concentrate, dextrin mixing is added, suppresses, it is dry, tablet is made.
Experimental example
Experimental method：Experimental animal is purchased from Beijing dimension tonneau China, strain C57, every group of animal 10.
With compound diphenoxylate (0.1mg/10g) gavage, Constipated mice is made.Each group animal is gavaged respectively, continuously
40 days gavages.It needs to manufacture the deficiency of vital energy and the secret type mice with constipation model of gas simultaneously, i.e., on the Constipation Model basis that diphenoxylate is produced
On it is full uneven plus swimming 2 times daily with famine, along with tying up tired mouse four limbs by its irritability.
Experimental group：It is gavaged after modeling using tablet made from embodiment 9 as experimental group, specification；5mg/ pieces, by the tablet
It grinds, then adds and steam feedback water, suspension is made into, with 0.5ml/10g gavages.
Blank group：Not modeling, with 0.1ml/10g physiological saline gavages.
Model group, with 0.1ml/10g physiological saline gavages after modeling.
Positive controls：With Mosapride 0.3mg/ml gavages after modeling.
It is any of the above to press《Herbal pharmacology research methodology》Calculate gavage after Chinese medicine people's mouse equivalent dose.
Observation index：Small mouse's head pellet just efflux time, mouse argol points, the quantity of weight and non-defecation mouse, then
Respectively different reagent gavage needs, with prepared Chinese ink gavage, to re-record the time that first grain melena is discharged in mouse after 30 minutes.
Argol points, weight and the quantity of non-defecation mouse of 3 days record each group mouse.
The experimental results are shown inthe following table：
| Project | Experimental group | Blank group | Model group | Positive controls |
| First grain melena efflux time (min) | 59.2±11.4*# | 54.6±14.7 | 131.4±35.2 | 67.8±18.5* |
| Mouse melena grain number | 6.1±0.2*# | 7.0±0.3 | 2.4±0.4 | 4.8±0.3* |
| Stool in mice weight (g) | 4.7±0.4* | 5.3±0.3 | 1.7±0.4 | 4.0±0.2* |
| Non- defecation number of mice (only) | 0 | 0 | 8 | 2 |
*p<0.05, vs model group；#p<0.05, vs positive controls.
The deficiency of vital energy and the secret type mouse of gas are produced with irregular diet, binding and excessive fatigue, with giving compound on its basis
Fragrant promise ester produces Constipation Model.The drug that the upper experimental result display present invention is prepared is to (deficiency of vital energy and Qi-stagnation type) mice with constipation
Enterocinesia improve apparent, melena grain number and weight increases, defecation number of animals is reduced.And drug effect is better than Western medicine group.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, but it will be understood by those of ordinary skill in the art that：Its
It still can be with technical scheme described in the above embodiments is modified, either to which part or all technical features
Carry out equivalent replacement；And these modifications or replacements, various embodiments of the present invention skill that it does not separate the essence of the corresponding technical solution
The range of art scheme.
Claims (10)
1. a kind of drug for treating constipation, which is characterized in that the drug includes the material component of following proportioning：
2~8 parts by weight of 10~17 parts by weight of chrysanthemum, 1~6 parts by weight of potentilla discolor and matrimony vine.
2. drug according to claim 1, which is characterized in that the drug includes the material component of following proportioning：
3~7 parts by weight of 11~16 parts by weight of chrysanthemum, 2~5 parts by weight of potentilla discolor and matrimony vine.
3. drug according to claim 1, which is characterized in that the drug includes the material component of following proportioning：
4~6 parts by weight of 12~15 parts by weight of chrysanthemum, 3~4 parts by weight of potentilla discolor and matrimony vine.
4. drug according to claim 1, which is characterized in that the drug includes the material component of following proportioning：
5 parts by weight of 13~14 parts by weight of chrysanthemum, 3.5 parts by weight of potentilla discolor and matrimony vine.
5. drug according to claim 1, which is characterized in that the drug further comprises auxiliary material or excipient.
6. drug according to claim 1, which is characterized in that the dosage form of the drug be pill, powder, paste, tablet,
Granule, pastille, capsule, aqua or tincture.
7. the method for preparing drug according to any one of claims 1 to 6, which is characterized in that include the following steps：It will be each
Raw material crushes, and mixes.
8. the method according to the description of claim 7 is characterized in that the method further includes, by the drug packages in medicine bag
In.
9. the method for preparing drug according to any one of claims 1 to 6, which is characterized in that include the following steps：
(a) each starting material with water is decocted, obtains decocting liquid, or extracted with ethanol water, obtains extracting solution；
(b) required dosage form is prepared with the decocting liquid or the extracting solution.
10. purposes of the drug described in any one of claim 1 to 5 in preparing the medicament for treating constipation.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145180A (en) * | 1996-03-01 | 1997-03-19 | 石良永 | Health tea for aged people |
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2018
- 2018-04-25 CN CN201810380130.0A patent/CN108371682A/en active Pending
Patent Citations (1)
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| CN1145180A (en) * | 1996-03-01 | 1997-03-19 | 石良永 | Health tea for aged people |
Non-Patent Citations (2)
| Title |
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| 刘丽芳: "柴芍四君汤加味治疗功能性便秘（气虚兼气滞型）的临床观察和实验研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
| 刘工文: "喝的时尚", 《林业财务与会计》 * |
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