CN104138557A - Chinese herbal medicine compound preparation for preventing and treating senile dementia - Google Patents
Chinese herbal medicine compound preparation for preventing and treating senile dementia Download PDFInfo
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- CN104138557A CN104138557A CN201410422068.9A CN201410422068A CN104138557A CN 104138557 A CN104138557 A CN 104138557A CN 201410422068 A CN201410422068 A CN 201410422068A CN 104138557 A CN104138557 A CN 104138557A
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Abstract
The invention relates to a Chinese herbal medicine compound preparation for preventing and treating senile dementia. The Chinese herbal medicine compound preparation is prepared through the steps of preparing thick paste from seven traditional Chinese medicines including cinnamon, peanut leaves, sunflower seeds, fructus alpinia oxyphylla, dendrobe, walnut kernels, placenta hominis through processes such as alcohol extraction, water boiling, alcohol precipitation and the like; then, adding a proper amount of auxiliary materials, uniformly mixing, drying and smashing to form fine powder; adding a proper amount of corrigent, and uniformly mixing; granulating by using ethanol with a certain concentration, and drying; and adding a proper amount of lubricating agent, and uniformly mixing to prepare the preparation. The Chinese herbal medicine compound preparation has the effects of warming and invigorating kidney yang as well as invigorating the brain and developing intelligence, is suitable for syndrome types such as liver and kidney deficiency, spleen-kidney deficiency and the like with the symptoms as follows: oldness and vigor attenuation as well as encephala deficiency or valetudinarianism and blood and qi deficiency or improper diet and spleen and stomach deficiency or unsmooth feelings, stagnation of liver qi, qi stagnation and blood stasis. The Chinese herbal medicine compound preparation is capable of treating both symptoms and root causes, convenient to use, controllable in quality, exact in curative effect, safe and reliable.
Description
Technical field
The present invention relates to a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, see for prevention and treatment senile dementia: moving obstacle, under the state that there is no disturbance of consciousness, the obstacle of the aspects such as memory, thinking, analysis judgement, visual space identification, emotion.Its characteristic pathological change is cerebral cortex atrophy, and with amyloid-beta deposition, neurofibrillary tangles, mass memory neuron number reduces, and the formation of senile plaque.There is no at present the medicine of specific treatment or reverse progression of disease.
Background technology
It is aging that alzheimer disease (Alzheimer's disease disease) refers to that old degree of aging exceedes physiological, or premature aging, causes disordered brain function, causes acquired, persistence disturbance of intelligence.The in the situation that of unconscious obstacle, there are memory and cognitive function disorder, with speech, visual space technical ability, emotion or personality changes, and affect its social activity.Owing to there is no effective medicine and means, alzheimer disease increases the weight of day by day, finally because of body complication threat to life.Onset concealment, early symptom is nearly hypomnesis, personality changes, intelligence declines to some extent, and spatial orientation is bad, and often go astray from the group, fail to see homeward journey or initiative and reduce, labile affect, but daily life still can keep.Further develop cognitive decrease, occur aphasia, agnosia, sometimes sicken for consciousness.Can occur neural location sign, daily life can not be taken care of oneself, often has shameless behavior, ethics behavior all can change.Very occur auditory hallucination, photis, vain hope, manic or depressed symptom.Late period comprehensive disturbance of intelligence, bed, without autonomic movement.Keep silent without language or the fragmentation of giving ambiguous stayements, can't take care of oneself at all, finally because complication causes death.Modal complication is pulmonary infection, skin infection, urinary system infection, or chronic failure, dyscrasia, multiple organ failure, MOF and threat to life.The investigation such as Yan Fang show that over-65s senile dementia sickness rate is 1-3%, within 65 years old, dementia incidence rate is 2.5%, it is more than 90 years old that dementia incidence rate is 85.6%, according to another report, senile dementia mostly occurs over-65s old man, accounts for 4-5%, within 75 years old, account for above 10%, within 85 years old, account for above 20%, prompting every growth of old man's age 10 years old, prevalence of dementia approximately increases by 1 times.According to another report, old women is suffered from senile dementia a little more than male.There is no at present specific medicament and special therapeutic method, with early prevention, actively self health care is particularly important.China's Chinese medicine has the history of more than 5,000 year, according to Chinese medicine theory, except actively preventing and treating hypertension, heart and brain disease, diabetes, control blood pressure and blood glucose, reduce blood fat and hyperlipidemia be outside one's consideration the phychology that also will keep good, keep on a diet, coordinate the traditional Chinese medical science to adopt effectively prevention and the treatment senile dementia of medicine of invigorating the liver and kidney spleen invigorating Fructus Alpiniae Oxyphyllae
We take from the well-known traditional Chinese medical science and apply clinical experience side for many years, warming and recuperating the kidney-YANG, nourishing the brain and improving intelligence is main, to mend fiery supporing yang key medicine Cortex Cinnamomi as monarch drug, adopt multi-medicament composition of prescription, and press existing new drug requirements of customs declaration through Yaogu Sci-Tech Development Co., Ltd., Wuhan, preferred formulation moulding process, develop Chinese medicine, the preparation of natural drug new drug six classes, in side, seven flavor medicine material has been imperial medical material, not containing drug toxicity and eighteen incompatible medicaments, the medicine of the incompatibilitys such as nineteen medicaments of mutual restraint, its reasonable recipe, there is treating both the principal and secondary aspects of a disease, easy to use, quality controllable, drug effect is definite, safe and reliable advantage, can meet the demand of extensive patients.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, this medicine has effect of warming and recuperating the kidney-YANG, nourishing the brain and improving intelligence, is applicable to the pattern of syndrome such as caused by liver and kidney deficiency, spleen kidney deficiency, and card is shown in that old essence declines, brains deficiency, or eipathia asthenia, vim and vigour virtual loss, or eating and drinking without temperance, weakness of the spleen and stomach, or feelings are not easypro, depression of liver-QI, qi depression to blood stasis.
Medicine of the present invention is made up of the raw material of Chinese medicine of following weight proportioning:
Cortex Cinnamomi 60 ~ 200g Folium Arachidis hypogaeae 60 ~ 200g sunflower seed 100 ~ 350g Fructus Alpiniae Oxyphyllae 100 ~ 350g Herba Dendrobii 60 ~ 200g Semen Juglandis 60 ~ 200g Placenta Hominis 20 ~ 100g
The optimum weight proportioning of the each raw material of the present invention is:
Cortex Cinnamomi 150g Folium Arachidis hypogaeae 150g sunflower seed 300g Fructus Alpiniae Oxyphyllae 300g
Herba Dendrobii 150g Semen Juglandis 150g Placenta Hominis 50g
Preparation method of the present invention is: above seven tastes, get the 70% alcoholic solution reflux, extract, twice that Cortex Cinnamomi, Folium Arachidis hypogaeae, sunflower seed, Semen Juglandis add 6 times of amounts, and each 1.5 hours, merge extractive liquid, Fructus Alpiniae Oxyphyllae, Herba Dendrobii, Placenta Hominis adds 8 times of water gagings, decoct twice, each two hours, filter, merging filtrate, filtrate is concentrated into relative density 1.15(60 DEG C) thick paste, add ethanol to containing alcohol amount 70%, stir, place 24 hours, get supernatant, filter, the extracting solution such as filtrate and Cortex Cinnamomi merges, reclaim ethanol, be evaporated to relative density 1.23(60 DEG C) thick paste, add appropriate amount of auxiliary materials to mix, dry, be ground into fine powder, add appropriate correctives to mix, use finite concentration alcohol granulation, dry, add moderate lubrication agent, mix, make preparation, obtain.
Medicine of the present invention can add one or more pharmaceutic adjuvants as required, pharmaceutic adjuvant can be diluent, binding agent, correctives, excipient, as sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin, magnesium stearate, micropowder silica gel.
The present invention can make any clinical pharmaceutical preparation that is applicable to according to existing process of Chinese medicine preparation, comprises solid preparation (hard capsule, granule, tablet, dispersible tablet, soft capsule, drop pill, pill), liquid preparation (syrup, soft extract, oral liquid, mixture) etc.The preferred dosage form of the present invention is capsule, tablet.
The present invention is formed by seven taste Chinese prescriptions, and wherein Cortex Cinnamomi benefit fire is supporing yang, warming and recuperating the gate of life, let the fire back to its origin, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, promoting blood circulation, therefore be monarch drug; The linoleic acid content of the raw sunflower seed of sunflower seed can reach 70%. blood cholesterol levels that contribute to reduce human body, is of value to protection cardiovascular and cerebrovascular vessel health.In raw sunflower seed, vitamin E prevents cell ageing, prevention adult disease.Raw sunflower seed also has the effect of Cure for insomnia, memory reinforcing; Fructus Alpiniae Oxyphyllae acrid in the mouth, warm in nature, warming the spleen warming the kidney solid and gas arresting seminal emission; Semen Juglandis sweet in the mouth, warm in nature, nourishing the liver and kidney, the logical brain of the kidney invigorating, useful wisdom, also has benefiting qi and nourishing blood, effect of moistening the lung and resolving the phlegm in addition.To be ministerial drug.Folium Arachidis hypogaeae slightly sweet flavor, property is flat, heat-clearing and toxic substances removing, the blood pressure lowering of allaying excitement; Herba Dendrobii sweet in the mouth, cold nature.Energy replenishing YIN and removing heat, reinforcing stomach reg fluid; , Placenta Hominis sweet-salty, warm in nature, for deficiency of kidney-QI, essence and blood is empty to be lost.
An important feature of the present invention is pure Chinese medicinal preparation, and determined curative effect, toxic and side effects are little, forms the place of the through focus of drug effect by motherland's traditional medicine prescription.Meanwhile, after preparations shaping, facilitated carrying and taking of patient, and quality controllable, safety good.
Using method of the present invention: one day twice, each two, avoid greasy, maror during medication.
The present invention derives from hospital clinical through proved recipe, and in 2011-2013 clinical observation patients with Alzheimer disease 85 examples, clinical summary was as follows:
In 85 routine patients, age 56-78 year, 69 years old mean age, course of disease 0.5-3, wherein male 50 examples, female's 35 examples, 85 selected examples are all selected with reference to the diagnostic criteria of American Psychiatric Association's (psychotic diagnostic and statistical manual) third edition (ASM-III) and international disease classification standard (ICD-10).Selected case all meets Chang Gu river Dementia scale, scoring < 10.Use this product treatment one day twice, each two 30 days is a course for the treatment of, according to mental state scale (MMSE) evaluation criterion, judges total effects: normal: before and after treatment, intelligence mark improves more than 10 points, and total score reaches 23 points; Effective: before and after treatment, intelligence mark raising 5-10 divides; Effective: before and after treatment, intelligence mark improves lower than 5 points; Invalid: treatment front and back intelligence mark is unchanged or treatment is front declines.Result: normal 12 examples (14.1%), effective 38 examples (44.7%), effective 27 examples (31.8%), invalid 8 examples (9.4%)
Model case: Hu: man, 71 years old, being reticent, often misdrawed clothes, is not familiar with household, and before being admitted to hospital, appearance walking shakiness, easily excited, talking nonsense, and hit the person, especially always say night and oneself breaking people.Use after the course for the treatment of of medicine of the present invention, to murmur to oneself situation reduces than before, can understand others' question brief answer, and freely, stability is strengthened in walking.
Liu: man, 56 years old, show as recent memory and decline, decline with computing power, to calculate slowly, ability to work declines, and faculty of understanding is normal, uses after the course for the treatment of of medicine of the present invention, and memory, computing capability are greatly improved, and ability to work is recovered normally.
The results of pharmacodynamic test of the present invention's treatment and prevention senile dementia is as follows:
With 60 of 15 monthly age senile rats, within 4 weeks, add with D-galactose lumbar injection senile dementia (AD) model that the injection of amanitin brain kernel is manufactured, be divided at random three groups according to weight data: AD model group, matched group, of the present invention group, twice of every day, each 2, medication in continuous 4 weeks, the improvement situation of application Morris determined with Morris water learning and memory in rats.There were significant differences for result the present invention and model group, matched group (P < 0.05) illustrates that the present invention can obviously improve senile dementia (AD) rat space exploration learning and memory function.
Detailed description of the invention
Realize and further illustrating of the present invention by following detailed description of the invention, but should not be understood to any limitation of the invention.
Press column weight amount and take raw material:
Cortex Cinnamomi 150g Folium Arachidis hypogaeae 150g sunflower seed 300g Fructus Alpiniae Oxyphyllae 300g
Herba Dendrobii 150g Semen Juglandis 150g Placenta Hominis 50g
Preparation method: above seven tastes, get the 70% alcoholic solution reflux, extract, twice that Cortex Cinnamomi, Folium Arachidis hypogaeae, sunflower seed, Semen Juglandis add 6 times of amounts, each 1.5 hours, merge extractive liquid, Fructus Alpiniae Oxyphyllae, Herba Dendrobii, Placenta Hominis adds 8 times of water gagings, decoct twice, each two hours, filter, merging filtrate, filtrate is concentrated into relative density 1.15(60 DEG C) thick paste, add ethanol to containing alcohol amount 70%, stir, place 24 hours, get supernatant, filter, the extracting solution such as filtrate and Cortex Cinnamomi merges, reclaim ethanol, be evaporated to relative density 1.23(60 DEG C) thick paste, add appropriate amount of auxiliary materials to mix, dry, be ground into fine powder, add appropriate correctives to mix, use finite concentration alcohol granulation, dry, add moderate lubrication agent, mix, make preparation, obtain.
Claims (5)
1. for preventing and treat Chinese prescription and the preparation of senile dementia, it is characterized in that it is to be made up of the raw material of Chinese medicine of following weight proportion:
Cortex Cinnamomi 60 ~ 200g Folium Arachidis hypogaeae 60 ~ 200g sunflower seed 100 ~ 350g Fructus Alpiniae Oxyphyllae 100 ~ 350g Herba Dendrobii 60 ~ 200g Semen Juglandis 60 ~ 200g Placenta Hominis 20 ~ 100g
According to claim 1 a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, it is characterized in that this product is made up of the material component of following optimum weight proportioning:
Cortex Cinnamomi 150g Folium Arachidis hypogaeae 150g sunflower seed 300g Fructus Alpiniae Oxyphyllae 300g
Herba Dendrobii 150g Semen Juglandis 150g Placenta Hominis 50g
According to claim 1 a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, it is characterized in that preparation method is: above seven tastes, get Cortex Cinnamomi,, Semen Juglandis, sunflower seed add 70% alcoholic solution reflux, extract, twice of 6 times of amounts, each 1.5 hours, merge extractive liquid, Folium Arachidis hypogaeae, Fructus Alpiniae Oxyphyllae, Herba Dendrobii, Placenta Hominis adds 8 times of water gagings, decoct twice, each two hours, filter, merging filtrate, filtrate is concentrated into relative density 1.15(60 DEG C) thick paste, add ethanol to containing alcohol amount 70%, stir, place 24 hours, get supernatant, filter, the extracting solution such as filtrate and Cortex Cinnamomi merges, reclaim ethanol, be evaporated to relative density 1.23(60 DEG C) thick paste, add appropriate amount of auxiliary materials to mix, dry, be ground into fine powder, add appropriate correctives to mix, use finite concentration alcohol granulation, dry, add moderate lubrication agent, mix, make preparation, obtain.
2. according to claim 1 a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, wherein appropriate amount of auxiliary materials is diluent, excipient.
3. according to claim 1 a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, wherein adjuvant is one or more in sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin.
4. according to claim 1 a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, wherein lubricant is one or more in magnesium stearate, micropowder silica gel.
5. according to claim 1 a kind of for preventing and treat Chinese prescription and the preparation of senile dementia, wherein preparation is the one in capsule, granule, tablet, powder, suspensoid, bag tea agent.
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| CN201410422068.9A CN104138557A (en) | 2014-08-26 | 2014-08-26 | Chinese herbal medicine compound preparation for preventing and treating senile dementia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113889215A (en) * | 2021-10-13 | 2022-01-04 | 芸豆数字科技有限公司 | Incompatibility early warning prompting method, device, equipment and storage medium |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1875769A (en) * | 2005-06-10 | 2006-12-13 | 李东坡 | Brain-nourishing health food and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1875769A (en) * | 2005-06-10 | 2006-12-13 | 李东坡 | Brain-nourishing health food and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 胡增峣等: "中药复方治疗老年痴呆的用药规律分析", 《中药药理与临床》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113889215A (en) * | 2021-10-13 | 2022-01-04 | 芸豆数字科技有限公司 | Incompatibility early warning prompting method, device, equipment and storage medium |
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