CN107006694B - A kind of beef cattle, mutton sheep plant essential oil composition, preparation method and applications - Google Patents
A kind of beef cattle, mutton sheep plant essential oil composition, preparation method and applications Download PDFInfo
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- CN107006694B CN107006694B CN201710166576.9A CN201710166576A CN107006694B CN 107006694 B CN107006694 B CN 107006694B CN 201710166576 A CN201710166576 A CN 201710166576A CN 107006694 B CN107006694 B CN 107006694B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
Abstract
The present invention provides a kind of beef cattle, mutton sheep plant essential oil composition, preparation method and applications.Beef cattle, mutton sheep plant essential oil composition include the raw material of following parts by weight: being sustained the mixture of 1-15 parts of 1-8 parts of fennel oil, the cinnamic acid of processing and the carvacrol of rumen bypass processing and Thymol, the carvacrol of rumen bypass processing and the mixture of Thymol include 1-8 parts of carvacrol, 1-8 parts of Thymol and 10-40 parts of rumen bypass carrier.When preparation, carvacrol and Thymol are done into rumen bypass coating with carrier with rumen bypass, obtained product is uniformly mixed with fennel oil and cinnamic acid, obtains beef cattle, mutton sheep plant essential oil composition.Beef cattle of the present invention, mutton sheep are mainly used for substituting Rumensin in cud with plant essential oil composition, harmful bacteria is killed in suppression in intestine of ruminants simultaneously, promote beneficial bacterium proliferation, the digestion and absorption of nutriment in promotion beef cattle, mutton sheep small intestine, and then improve survival rate, beef cattle, mutton sheep diarrhea and constipation are prevented, daily gain and feed conversion rate are improved, prevents yellow mark meat.
Description
Technical field
The invention belongs to field of feed additive technology more particularly to a kind of beef cattle, mutton sheep plant essential oil composition, systems
Preparation Method and its application.
Background technique
The use of antibiotic ionophore (Rumensin) can reduce because of lumen fermentation caused by energy and protein
Loss.However, drug-fast bacteria may be remained and generate in livestock products without by big well-established by adding antibiotic in feed.
In January, 2006, European Union has prohibited the use of antibiotic.China cannot clearly add antibiotic in milk cow forage,
Although not being banned from use antibiotic in beef cattle, sheep feed, in today that food safety is increasingly paid attention to, resist
Application of the raw element in feed can will gradually be prohibited.Based on this, animal nutrition science man begins one's study the substitution of antibiotic
Object regulates and controls lumen fermentation, including yeast, organic acid, plant extracts (mainly plants essential oil) and probiotic.
Plants essential oil has extensive antibacterial activity, has inhibitory or killing effect for Gram-negative bacteria and positive bacteria.These
What substance had can promote lumen fermentation, some inhibition lumen fermentations, and some inhibition methane generates, and some can change volatility
The composition and nitrogen metabolism of fatty acid.It is some the study found that certain plants essential oil and its group branch change each volatile fatty acid
Ratio acts on (for example reducing proportion of acetic acid, increase propionic acid ratio) similar with coban, these are considered as addition plant essence
The Beneficial Effect of oil.
Thymol (C10H14O), it is also Thymol, is the isomer of carvacrol, to most of Gram-positives
Bacterium and Gram-negative bacteria have inhibiting effect, are the active constituents for studying a kind of more plants essential oil at present.Borchers
(1965) influence of the thymol to lumen fermentation is had studied in vitro method, the thymol for adding 1000mg/L reduces culture
The concentration of ammonia nitrogen improves the concentration of amino acid nitrogen, illustrates that it can inhibit deamination.Evans etc. (2000) report,
Under the conditions of pure culture, thymol has an impact to bargen's streptococcus and the energetic supersession for ruminating the crescent monad of beast.It can be dropped
The concentration of low-methoxyl alkane and lactic acid, but the production of nutritive digestibility and general volatile fatty acid can be reduced by improving additive capacity
Amount.Addition 100-400mg/L thymol increases the ratio of acetic acid and propionic acid.Sensitivity of the crescent monad to thymol
Property by force than bargen's streptococcus (main Lactic Acid Producing), so as to cause the accumulation of lactic acid in rumen fluid, causes rumen fluid ph to drop
It is low, it has a negative impact to lumen fermentation.And the purpose of regulating rumen is exactly the opposite, it should try hard to reduce the concentration of lactic acid.It answers
The growth of the stimulation meniscus monad, inhibits the growth of bargen's streptococcus.It is slow that cud can be added while adding thymol
Electuary (NaHCO3Deng).Castillejos etc. (2006) in vitro study shows that the thymol of 50mg/L does not have lumen fermentation
It influences, but the dosage of 500mg/L reduces the concentration of general volatile fatty acid and ammoniacal nitrogen；Long-term continuous cultivation and fermentation system
Result of study shows that the optimal dose of thymol is 50-500mg/L.In addition, the effect of thymol is by daily ration and cud
The influence of pH value.In daily ration essence slightly than being 40: 60 (coarse fodder is alfalfa), under conditions of pH is 6.4, thymol is improved
The ratio of acetic acid and propionic acid.In daily ration essence slightly than being 90: 10 (coarse fodder is stalk, and fine fodder is corn, barley and dregs of beans), pH is
Under the conditions of 5.5, thymol reduces the ratio of acetic acid and propionic acid.
Fennel oil, may also be referred to as oil of badian, and octagonal mattress perfume (or spice) is Magnoliaceae illiciumverum platymiscium illiciumverum (Illicium
Verum Hookf.) ripening fruits, alias anise, aniseed, spiced octagonal, warm-natured, acrid flavour, be special product of China spice and
The condiment of Chinese medicine and herbal.
Oil of badian (Star Anise Oil) be extracted from the fruit or branches and leaves of Chinese anise it is a kind of at
Divide more complex natural perfume material oil, main component is anethole, that is, anethole (Anethole), account for about 80%-90%, point
Minor is C10H12O, Chinese be it is dilute to acrylic anisic acid, methylchavicol, Anethole and fennel, it is generally colourless or yellowish
Color volatility oily liquids has preferable antibacterial, increasing leukocyte, analgesia, insecticidal activity and free radical resisting oxidation.Eight
Erect hypecoum oil can be used for the flavoring of toothpaste and tooth powder, improve the taste of medicament, it can also be used to the production of candy and drinks, in China
All make fumet with it in many meat products；As Chinese medicine, oil of badian has appetizer under the gas, cold dispelling, warm kidney, analgesic equivalent
Fruit, some researches show that it to have preferable antibacterial, insecticidal activity and free radical resisting oxidation in recent years.Production is directed in the world
Specific drug-Tamiflu raw material of bird flu are exactly the shikimic acid extracted from Chinese anise.
The antibacterial activity of fennel oil is related with the ether group on its aromatic rings, and the oxygen atom in thioether group and bacterial growth are numerous
The oxydasis containing sulfydryl in cysteine molecule necessary to spreading out is cystine linkage, stop bacterium cannot due to a lack of cysteine
Only biological oxidation damages the eubolism of bacterium to prevent bacterial cell division, inhibits the growth and procreation of bacterium.
The fennel oil and anisole for adding 2.2mg/l reduce general volatile aliphatic acid yield and acetic acid/propionic acid ratio, improve fourth
The ratio of acid, anisole are bigger than the influence of fennel oil.Concentration of the two all without influencing ammonia nitrogen.Cardozo etc. is using continuous
Culture systems have studied influence of the 0.22mg/l fennel oil to protein degradation, the concentration of peptide and ammonia nitrogen are improved, to volatility
Fatty acid does not influence.When beef cattle is research object, pH5.5, thick ratio of essence is 90:10 (coarse fodder is stalk), ammonia nitrogen concentration with
The ratio of acetic acid reduces, and propionic acid ratio improves.Cardozo etc. adds fennel in the growing cattle daily ration that ratio is 90:10 smart slightly
Sesame oil is improved the trend of dry matter intake, and general volatile fatty acid concentration does not change, and proportion of acetic acid reduces, propionic acid
Molar ratio improves, and the third ratio of second reduces, and fennel oil also reduces the concentration of ammonia nitrogen and the quantity of protozoon simultaneously.Add anise
Sesame oil and chilli oil, dry matter intakes amount increase.In vitro in test, Rumen Fermentation becomes towards the trend for reducing first institute
Change.Liu Yanci etc. selects fennel seeds, cortex cinnamomi, rhizoma zingiberis, Radix Glycyrrhizae, mountain to study influence of the Chinese herb feed additive to chicken flavor
The Chinese herbal medicines such as short, bristly hair or beard, Divine Comedy, malt are as feed addictive, and inosine acid content dramatically increases in Muscle of chicken as the result is shown, significantly
Improve chicken flavor
Cinnamic acid (C9H8O) there is antibacterial activity, be the main active of cassia oil, account for 75% of extract or so.
Cardozo etc. (2005) report, test use dosage for the continuous culture system of 0.22mg/L rumen fluid, the results showed that, it is right
Nitrogen metabolism has regulating and controlling effect, inhibits the activity of peptase, but to volatile fatty acid almost without effect.Cassia oil and cinnamic acid
Additive capacity is that 3000mg/L rumen fluid reduces general volatile fatty acid and ammonia nitrogen concentration.To single volatile fatty acid ratio
Influence it is different, cassia oil improves the molar ratio of acetic acid, but does not influence on the molar ratio of propionic acid and butyric acid,
Cinnamic acid improves the ratio of propionic acid, does not influence on acetic acid and butyric acid.These results indicate that cinnamic acid is the main of cassia oil
Active constituent, other compositions and cinnamic acid in cassia oil have interaction, and the effect of cinnamic acid is more ideal.Busquet etc.
(2005) every liter of rumen fluid is had studied using Dual-flow continuous culture fermentation system and adds 31.2,312mg cinnamic acid respectively to tumor
The influence of stomach fermentation.The result shows that improving the molar ratio of propionic acid and butyric acid which reduce the molar ratio of acetic acid.Ferme
It is reported Deng (2004), cinnamic acid can reduce the quantity of melaninogenicus, and this bacterium has the function of deamination.Above test knot
Fruit and discussion are obtained under conditions of high coarse fodder daily ration based on milk cow.Cardozo etc. (2005) uses smart slightly ratio for 90: 10
The rumen fluid of beef cattle under the conditions of daily ration, the in vitro study effect of cassia oil and cinnamic acid.When pH is 7, can both improve
The ratio of acetic acid and propionic acid reduces the concentration of ammonia nitrogen, shows that nutrient utilization efficiency reduces.Comparatively, when pH is 5.5,
Ammonia nitrogen concentration and the third ratio of second all reduce.
(2011) such as domestic scholars woods waves have studied cinnamon oil, origanum oil and its main component cinnamic acid, perfume (or spice) in vitro method
0,50,200,500 and 750mg/L, hair are added in the influence that celery phenol ferments to vitro Rumen and methane generates in fermentation liquid respectively
Existing general volatile fatty acid concentration is reduced with the increase of plants essential oil additive amount, and high dose (500,750mg/L) adds
When, entire fermentation process is significantly inhibited.
In conclusion addition cinnamic acid and fennel oil have positive acting to ruminant tumor gastric function, it can improve tumor
Propionic acid yield in stomach reduces acetic acid/propionic acid ratio.And adding thymol has negative role to ruminant tumor gastric function, that is, drops
Low propionic acid yield improves acetic acid/propionic acid ratio.
Han Xu (2013) on laying hen studies have shown that addition origanum oil after can reduce enteron aisle Escherichia coli, Salmonella
The quantity of bacterium improves enteron aisle lactic acid bacteria and bifidobacteria, improves the height of intestinal villi, reduce the depth of crypts, improves
The activity of enteron aisle amylase, trypsase and lipase, increases glucose transporters (SGLT1, GLUT2) and small peptide transhipment carries
The mrna expression amount of body (PePT1), and then improve laying hen enteron aisle digestion and absorption function, improve the quantity of small bowel lymphatics cell.Hao
Dan Dan (2014), further studies have shown that the amount of CD4+ in spleen can be improved after addition origanum oil, reduces CD8+ on laying hen
Amount, improve CD4+/CD8+ ratio, the amount of IgG, IgA, IgM in chicken serum can be improved.The expression quantity of IL-2mRNA in spleen
It is significantly improved with the expression quantity of IL-4mRNA.Show that the immunity of body significantly enhances.
Summary of the invention
In view of the problems of prior art, the present invention provides a kind of beef cattle, mutton sheep plant essential oil composition, preparation
Method and its application are mainly used for substituting Rumensin in cud, while harmful bacteria is killed in suppression in intestine of ruminants, promotes to have
Beneficial bacteria is proliferated, the digestion and absorption of nutriment in promotion beef cattle, mutton sheep small intestine, and then improves survival rate, prevents beef cattle, mutton sheep
Diarrhea and constipation improve daily gain and feed conversion rate, prevent yellow mark meat.
The technical scheme to solve the above technical problems is that
A kind of beef cattle, mutton sheep plant essential oil composition, the raw material including following parts by weight: 1-8 parts of fennel oil, cinnamic acid
The mixture of 1-15 parts and the carvacrol and Thymol that are handled through rumen bypass, in the carvacrol and hundred of rumen bypass processing
The mixture of fragrant phenol includes 1-8 parts of carvacrol, 1-8 parts of Thymol and 10-40 parts of rumen bypass carrier.
Having the beneficial effect that using the above scheme
Beef cattle of the invention, mutton sheep are with the effect of each component in plant essential oil composition:
Fennel oil and cinnamic acid can substitute the proliferation that Rumensin promotes rumen microorganism in cud, improve and wave in cud
Hair property content of fatty acid, improves propionic acid yield, reduces acetic acid/propionic acid ratio；And carvacrol and Thymol discharge in enteron aisle,
Promote lactic acid bacteria and Bifidobacterium proliferation, suppression in enteron aisle to kill the harmful bacterias such as enteron aisle Escherichia coli, salmonella, improves nutriment
Digestion is absorbed and is transported.And then beef cattle, mutton sheep daily gain are improved, feed-weight ratio is reduced, feed conversion rate is improved, meanwhile, improve machine
Body immunity and disease resistance improve beef cattle, mutton sheep survival rate, the yellow mark meat of prevention.
The present invention is conducive to fennel oil and cinnamic acid and gives full play to work in cud by the ratio of the suitable component of setting
With, reach promote rumen microorganism proliferation, improve cud in Volatile fatty acid contents, improve propionic acid yield, reduce acetic acid/
Propionic acid ratio and other effects.And the ratio of carvacrol and Thymol is suitable, is conducive to preferably discharge in enteron aisle, promotes enteron aisle
The harmful bacterias such as enteron aisle Escherichia coli, salmonella are killed in middle lactic acid bacteria and Bifidobacterium proliferation, suppression, improve nutrient digestion, inhale
It receives and transports.And then beef cattle, mutton sheep daily gain are improved, feed-weight ratio is reduced, feed conversion rate is improved, meanwhile, further improve
Immunity of organisms and disease resistance improve beef cattle, mutton sheep survival rate, the yellow mark meat of prevention.
Further, the fennel oil be 2-5 parts by weight, cinnamic acid be 6-10 parts by weight, carvacrol be 3-5 parts by weight, hundred
In fragrant phenol be 3-5 parts by weight.
Having the beneficial effect that using above-mentioned proportional region using the above scheme, may further ensure that sustained release coating and
The successful preparation of rumen bypass coating, it is ensured that fennel oil and cinnamic acid play a role in cud, and Thymol and carvacrol are rear
It plays a role in enteron aisle.
Further, the rumen bypass is saturated fatty acid with carrier；The saturated fatty acid include C16 saturated fatty acid and
C16 or more saturated fatty acid；
In the saturated fatty acid, including C16-C18 saturated fatty acid, the content of C16-C18 saturated fatty acid are saturated fat
70% or more of fat acid.
Having the beneficial effect that using the above scheme carries out rumen bypass packet to carvacrol and Thymol by saturated fatty acid
Clothing processing, keeps carvacrol and Thymol rumen-protected, to guarantee that carvacrol and Thymol can play in enteron aisle
Effect.Selection saturated fatty acid is more advantageous to product and passes through cud；Ruminant is conducive to saturated fat using C16-C18
The consumption of fat acid is absorbed and is utilized.Preferably, 70% or more the content of C16-C18 can be further improved ruminant to fat
The utilizing status of acid.
Further, the rumen bypass is selected from stearic acid, stearate, the hydrogenated fatty acid of animal or plant, rouge with carrier
The mixing of one or more of fat alcohols or acrylic resin IV.
Having the beneficial effect that using the above scheme is conducive to further increase rumen bypass using the fatty acid of mentioned kind
Effect.
It further, further include following parts by weight of component: 1-20 parts and adsorbent 10-40 parts of coating carrier.
It further, further include solvent 30-60 parts by weight, the solvent can be water.
Having the beneficial effect that using the above scheme
Sustained release coating processing is carried out to fennel oil and cinnamic acid by coating carrier, makes cinnamic acid and fennel oil with sustained release agent
Form exist, be conducive to extend the action time of fennel oil and cinnamic acid in cud, keep its continual in cud
It plays a role.
Addition solvent is conducive to sufficiently dissolve coating carrier, and fennel oil and cinnamic acid is fully emulsified, is uniformly mixed, keeps away
Exempt from fennel oil, cinnamic acid volatilization；Adsorbent can make solvent adsorption, be conducive to avoid fennel oil, cinnamic acid volatilization.
Further, the coating carrier includes methylcellulose and yellow mustard glue, and the parts by weight of methylcellulose are 0.5-10
Part, the parts by weight of yellow mustard glue are 0.5-10 parts.
Having the beneficial effect that using the above scheme
It is used cooperatively using methylcellulose and yellow mustard glue as coating carrier and the suitable proportion of setting, first for it
Any raw material in his raw material or methylcellulose and yellow mustard glue, is more advantageous to slow release of the product in cud, reaches
Slow release effect avoids essential oil from volatilizing and aoxidize, reduces effect.
Further, the methylcellulose is a kind of in hydroxymethyl cellulose, sodium carboxymethylcellulose and sodium alginate
Or several mixing.
Having the beneficial effect that using the above scheme is conducive to further increase sustained release using the methylcellulose of mentioned kind
Effect.
Further, the adsorbent is white carbon black.
The present invention provides the preparation method of a kind of a kind of above-mentioned beef cattle, mutton sheep plant essential oil composition, including following step
It is rapid: carvacrol and Thymol to be done into rumen bypass coating with carrier with rumen bypass, obtained product and fennel oil and cinnamic acid mix
It closes uniformly, obtains beef cattle, mutton sheep plant essential oil composition.
Using the above scheme have the beneficial effect that fennel oil and cinnamic acid can substitute Rumensin and promote cud in cud
The proliferation of microorganism improves Volatile fatty acid contents in cud, improves propionic acid yield, reduces acetic acid/propionic acid ratio；And Sheep's-parsley
Phenol and Thymol discharge in enteron aisle, and lactic acid bacteria and Bifidobacterium proliferation, suppression in enteron aisle is promoted to kill enteron aisle Escherichia coli, sramana
The harmful bacterias such as Salmonella improve nutrient digestion, absorption and transhipment.And then beef cattle, mutton sheep daily gain are improved, feed-weight ratio is reduced,
Feed conversion rate is improved, meanwhile, immunity of organisms and disease resistance are improved, beef cattle, mutton sheep survival rate, the yellow mark meat of prevention are improved.
The present invention also provides a kind of above-mentioned beef cattles, the preparation method of mutton sheep plant essential oil composition, comprising the following steps:
Coating carrier is dissolved in solvent, fennel oil and cinnamic acid is added, is uniformly mixed, adsorbent absorption is added, it is mixed to obtain first
Close object；Carvacrol and Thymol are done into rumen bypass coating with rumen bypass with carrier, obtain the second mixture；By the first mixture
It is mixed with the second mixture, obtains beef cattle, mutton sheep plant essential oil composition.
Take having the beneficial effect that for above scheme
The present invention is cinnamic acid and fennel oil to be made sustained release agent substitution Rumensin to play a role in cud, be can be improved
Propionic acid yield reduces acetic acid/propionic acid ratio, improves function of rumen.Rumen bypass is made in carvacrol and Thymol, allows it
Safety cud, plays a role in enteron aisle.
It is considered that addition cinnamic acid and fennel oil have positive acting to ruminant tumor gastric function, it can improve cud
Middle propionic acid yield reduces acetic acid/propionic acid ratio.And adding thymol has negative role to ruminant tumor gastric function, that is, reduces
Propionic acid yield improves acetic acid/propionic acid ratio.So sustained release agent substitution cud is made in cinnamic acid and fennel oil on beef cattle, mutton sheep
Element plays a role in cud, and carvacrol and Thymol with it is rumen-protected play a role in enteron aisle it is necessary.
In this way, sustained release agent substitution Rumensin is made in cinnamic acid and fennel oil to play a role in cud, it can
To improve propionic acid yield, acetic acid/propionic acid ratio is reduced, improves function of rumen.Carvacrol and Thymol are protected with rumen bypass
Shield plays restraining and sterilizing bacteria effect in enteron aisle, improves digestion, absorption and the transhipment of enteral nutrition substance, and it is immune to improve ruminant
Power improves the daily gain and feedstuff-meat ratio of beef cattle, mutton sheep, improves dressing percentage.
It further, include following with rumen bypass with the specific method that carrier does rumen bypass coating by carvacrol and Thymol
Step: being heated to 90 DEG C of meltings with carrier for rumen bypass, carvacrol and Thymol be added according to the ratio, mixes, dry, cold later
But.
Rumen bypass is heated to 90 DEG C with carrier by having the beneficial effect that using the above scheme, is conducive to rumen bypass carrier
Sufficiently melting, plants essential oil and rumen bypass are sufficiently mixed with carrier, guarantee the uniformity and rumen bypass rate of product.
Above-mentioned beef cattle, mutton sheep can be applied with plant essential oil composition in cattle feed or meat sheep feed.
Specific embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
A kind of beef cattle, mutton sheep plant essential oil composition, the raw material including following parts by weight: 1-8 parts of fennel oil, cinnamic acid
The mixture of 1-15 parts and the carvacrol and Thymol that are handled through rumen bypass, in the carvacrol and hundred of rumen bypass processing
The mixture of fragrant phenol includes 1-8 parts of carvacrol, 1-8 parts of Thymol and 10-40 parts of rumen bypass carrier.
In various embodiments of the present invention, fennel oil is using oil of badian.
When preparation, comprising the following steps: carvacrol and Thymol are done rumen bypass coating with carrier with rumen bypass, obtained
Product be uniformly mixed with fennel oil and cinnamic acid, obtain beef cattle, mutton sheep plant essential oil composition.
Preferably, in above-mentioned formula, the fennel oil is 2-5 parts by weight, and cinnamic acid is 6-10 parts by weight, carvacrol 3-
5 parts by weight, Thymol are 3-5 parts by weight.
In above-mentioned formula, the rumen bypass is saturated fatty acid with carrier.In the saturated fatty acid, including C16-C18 full
And fatty acid, the content of C16-C18 saturated fatty acid are 70% or more of saturated fatty acid.
Preferably, the fusing point of saturated fatty acid is 52 DEG C or 52 DEG C or more.
The saturated fatty acid can be selected from stearic acid, stearate, the hydrogenated fatty acid of animal or plant, fatty alcohols
Or acrylic resin IV etc., it can be to be one such, it can also be with several mixing therein.
In order to make fennel oil and cinnamic acid that there is slow release effect.A kind of beef cattle, mutton sheep plant essential oil composition, including with
The raw material of lower parts by weight: 1-8 parts of fennel oil, 1-15 parts of cinnamic acid, 1-8 parts of carvacrol, 1-8 parts of Thymol, rumen bypass carry
10-40 parts of body, 1-20 parts of coating carrier, 10-40 parts of adsorbent and 30-60 parts of solvent.
The coating carrier includes methylcellulose and yellow mustard glue.Methylcellulose is a kind of substance that can be dissolved in water.It is yellow
Mustard glue refers to the colloid extracted from yellow mustard seeds, can pass through the preparation of the conventional method of this field or commercially available acquisition.
The parts by weight of methylcellulose are 0.5-10 parts, and the parts by weight of yellow mustard glue are 0.5-10 parts.
The methylcellulose is selected from hydroxymethyl cellulose, sodium carboxymethylcellulose and sodium alginate etc., can be for wherein
One kind or in which several mixing, the adsorbent be white carbon black, the solvent be water.
A kind of beef cattle, mutton sheep plant essential oil composition preparation method, comprising the following steps: coating carrier is dissolved in molten
In agent, fennel oil and cinnamic acid is added, is uniformly mixed, adds adsorbent absorption, obtains the first mixture；By carvacrol and hundred
In fragrant phenol with rumen bypass with carrier do rumen bypass coating, obtain the second mixture；First mixture and the second mixture are mixed,
Obtain beef cattle, mutton sheep plant essential oil composition.
Carvacrol and Thymol can be used into following steps with the specific method that saturated fatty acid does rumen bypass coating:
Rumen bypass is heated to 90 DEG C of meltings with carrier, carvacrol and Thymol are added according to the ratio, mixes, it is dry later, cooling.
Note that the first mixture and the second mixture are merely for convenience of description, do not represent and limit the successive suitable of preparation
Sequence.For example, it is also possible to the first mixture can also be prepared again by first preparing the second mixture, it can also be by the first mixture and second
Mixture is prepared simultaneously.
The present invention is beef cattle, mutton sheep plant essential oil composition, and wherein fennel oil and cinnamic acid are made into sustained release preparation, and fragrant
Celery phenol and Thymol do rumen bypass coating.Its effect is that fennel oil and cinnamic acid can substitute Rumensin and promote tumor in cud
The proliferation of stomach microorganism improves Volatile fatty acid contents in cud, improves propionic acid yield, reduces acetic acid/propionic acid ratio；And it is fragrant
Celery phenol and Thymol discharge in enteron aisle, and lactic acid bacteria and Bifidobacterium proliferation, suppression in enteron aisle is promoted to kill enteron aisle Escherichia coli, sand
The harmful bacterias such as door Salmonella, improve nutrient digestion, absorption and transhipment.And then beef cattle, mutton sheep daily gain are improved, reduce material weight
Than, feed conversion rate is improved, meanwhile, immunity of organisms and disease resistance are improved, beef cattle, mutton sheep survival rate, the yellow mark of prevention are improved
Meat.
It is introduced below by specific embodiment.
Embodiment 1
This example prepares the beef cattle of total plants essential oil content 10%, mutton sheep plant essential oil composition
1) fennel oil 30g, cinnamic acid 40g, carvacrol 10g are weighed, Thymol 20g is spare.
2) methylcellulose 8g and yellow mustard glue 17g are weighed, the two is dissolved in 405ml distilled water, fennel oil and meat is added
Cinnamic aldehyde is uniformly mixed, adds 180g white carbon black and adsorbed, and mixes, obtains the first mixture.
3) weighing saturated fatty acid 290g, (in the saturated fatty acid, the content of C16-C18 saturated fatty acid is 72%, is satisfied
Fusing point with fatty acid is 52 DEG C), 90 DEG C of meltings are heated to, carvacrol and Thymol are added into molten product and mixes,
Mixed product is sprayed onto cooling tower by the spray head of drying machine with centrifugal spray to get the second mixture.
4) the first mixture and the second mixture are uniformly mixed, obtain the beef cattle of plants essential oil content 10%, mutton sheep is used
Plant essential oil composition.
Embodiment 2
This example prepares the beef cattle of total plants essential oil content 20%, mutton sheep plant essential oil composition.
1) fennel oil 40g, cinnamic acid 80g, carvacrol 40g are weighed, Thymol 40g is spare.
2) methylcellulose 10g and yellow 20 grams of glue of mustard are weighed, the two is dissolved in 400ml distilled water, be added fennel oil and
Cinnamic acid is uniformly mixed, adds 200 grams of white carbon blacks and adsorbed, and is uniformly mixed, obtains the first mixture.
3) weighing saturated fatty acid 170g, (in the saturated fatty acid, the content of C16-C18 saturated fatty acid is 72%, is satisfied
Fusing point with fatty acid is 52 DEG C), 90 DEG C of meltings are heated to, carvacrol and Thymol are added into molten product and mixes,
The mixed product is sprayed onto cooling tower by the spray head of drying machine with centrifugal spray to get the second mixture.
4) the first mixture and the second mixture are uniformly mixed, obtain the beef cattle of plants essential oil content 20%, mutton sheep is used
Plant essential oil composition.
Embodiment 3
This example prepares the beef cattle of total plants essential oil content 25%, mutton sheep plant essential oil composition
1) fennel oil 60g, cinnamic acid 80g, carvacrol 50g are weighed, Thymol 60g is spare.
2) methylcellulose 10g and yellow mustard glue 20g are weighed, the two is dissolved in 330ml distilled water, fennel oil and meat is added
Cinnamic aldehyde is uniformly mixed, adds 200g white carbon black and adsorbed, and mixes, obtains the first mixture.
3) weighing saturated fatty acid 190g, (content of C16-C18 saturated fatty acid and 72%, is saturated in the saturated fatty acid
The fusing point of fatty acid is 52 DEG C), 90 DEG C of meltings are heated to, carvacrol and Thymol are added into molten product and mixes,
The mixed product is sprayed onto cooling tower by the spray head of drying machine with centrifugal spray to get the second mixture.
4) the first mixture and the second mixture are uniformly mixed, obtain the beef cattle of plants essential oil content 25%, mutton sheep is used
Plant essential oil composition.
Embodiment 4
On the basis of embodiment 1, the weight that will prepare the raw material of beef cattle, mutton sheep plant essential oil composition adjusts are as follows:
Fennel oil 10g, cinnamic acid 10g, carvacrol 80g, Thymol 10g, methylcellulose 5g, yellow mustard glue 5g, saturated fatty acid
100g, white carbon black 100g and distilled water 600g, remaining is same as Example 1.Beef cattle, mutton sheep plant essential oil composition system
Preparation Method is same as Example 1.
Embodiment 5
On the basis of embodiment 1, the weight that will prepare the raw material of beef cattle, mutton sheep plant essential oil composition adjusts are as follows:
Fennel oil 80g, cinnamic acid 150g, carvacrol 80g, Thymol 80g, methylcellulose 100g, yellow mustard glue 100g, saturated fat
Sour 400g, white carbon black 400g and distilled water 200g, remaining is same as Example 1.Beef cattle, mutton sheep plant essential oil composition
Preparation method is same as Example 1.
Effect example
In order to verify the properties of product of beef cattle prepared by the present invention, mutton sheep plant essential oil composition, feeding experiment is carried out,
The specific implementation is as follows:
1 test material and method
1.1 experimental animals and experimental design
It selects that or so 12 monthly ages, body condition are good, the approximate Simmental of weight 50, is randomly divided into 5 groups, every group 10
Ox.Control group fed basal diet (mixed concentrate+corn stover: essence is slightly than 45:55)；Processing 1 (referred to as group 1) feeding is on basis
Coban 300mg/d is added on the basis of daily ration；Processing 2 (referred to as group 2), processing 3 (referred to as group 3) and processing 4 (referred to as group 4) point
Embodiment 1, embodiment 2,3 500g/ tons of gained plants essential oil mixture of embodiment are not added on the basis of basal diet.Preliminary trial period
10d, it is positive to try phase 60d.It tests and is carried out in August, 2016~2016 year October.
1.2 test daily rations and feeding management
It tests daily ration to prepare according to beef cattle nutritional need and feeding standard, be made of mixed concentrate and corn stover, group
At and trophic level be shown in Table 1.The essence of diet is slightly than being 45:55.The raising of test ox list slot, daily 07:00 and 19:00 feeding.From
By searching for food, free water.
1 experimental basis daily ration of table composition and trophic level
The acquisition of 1.3 samples and measurement
1.3.1 feed intake measurement and Feed Sample acquisition and analysis
Day by day feed intake and surplus forage amount are recorded during test in detail, acquires fine fodder and corn stover sample in proportion daily
Product save backup after measuring just moisture.
1.3.2 weight and daily gain
Feeding experiment starts and terminates, and whole oxen are weighed on an empty stomach by same sequence, and weighing even claims 2d every time, and 2 times difference is super
When 3%, 3d claims once, to be averaged again, finally calculates daily gain according to test whole story weight and number of days.
1.3.3 the acquisition and measurement of rumen fluid
Last 2d at the end of experimental period, before feeding (07: 00) and feeding after 3,6,9h using negative pressure device utilize stomach tube
Rumen fluid 200ml is acquired, with 4 layers of filtered through gauze, uses Startorius Basic pH Meter2, PB-20 type acidometer immediately
PH value is measured, takes supernatant in -40 DEG C of freezen protectives after 3000rpm centrifugation 10min.Ammonia is measured using magnesia direct distillation
State nitrogen.Take rumen fluid 1ml, 25% metaphosphoric acid solution of 0.2ml be added, be uniformly mixed, placed in ice-water bath after 30min in
16000rpm is centrifuged 15min, supernatant is then taken, with GC102AF gas chromatograph for determination volatile fatty acid (VFA), chromatography
Column is φ 4 (outer) × 2M glass column, and stationary phase PEG-20M, coating concentration 3%, carrier is Chromsorb WAWDMCS；Color
160 DEG C of column temperature, 200 DEG C of temperature of vaporization chamber of spectrum；Air pressure 0.12Mpa, Hydrogen Vapor Pressure 0.06Mpa, nitrogen pressure 0.08Mpa；
Nitrogen (carrier gas) flow velocity 30ml/min, hydrogen flow rate 60ml/min, air velocity 360ml/min；Sensitivity 10-10, decaying 16；
1 μ l of sample volume.
1.4 data processings and statistical analysis
The One-way-anova of data application SPSS statistical analysis software carries out variance analysis and LSD Multiple range test.
2 results and analysis
The influence of 2.1 pairs of beef cattle production performances
This testing inspection feed intake of ox, daily gain and feed conversion rate etc., as a result see Table 2 for details.
Influence of the table 2 to ox feed intake, daily gain and feed efficiency
Note: there is identical expression difference not significant (P > 0.05) in colleague letter a, b, c, alphabetical difference person indicates that difference is aobvious
It writes (P < 0.05).
As can be seen from Table 2, original body mass difference is not significant (P > 0.05) between test each group；4 processing end weight and
Average daily gain is all significantly higher than control group (P < 0.05), organizes 2 average daily gains and feed-weight ratio is substantially less than group 1, group 3 and group
4, terminate weight lower than other processing, but difference is not significant；Group 3 and group 4 are all excellent in average daily gain, end weight and feed-weight ratio
In group 1, but difference is not significant.
Influence of the table 3 to Simmental lumen fermentation
Note: there is identical expression difference not significant (P > 0.05) in colleague letter a, b, c, alphabetical difference person indicates that difference is aobvious
It writes (P < 0.05).
As can be seen from Table 3, test each group between pH value, acetic acid/propionic acid, ammoniacal nitrogen be significantly better than control group (P <
0.05)；Group 1, group 3 and 4 each test indexes of group are better than 2 (P < 0.05) of group；Group 3, the pH value of group 4 are better than group 1, the not significant (P of difference
>0.05)；The ratio of second third, the ammonia nitrogen concentration of group 4 are better than group 1, and difference is not significant (P > 0.05)；The second third of group 1 is denseer than, ammoniacal nitrogen
For degree better than group 3, difference is not significant (P > 0.05).
3 summarize
Beef cattle of the present invention, mutton sheep plant essential oil composition can improve ruminal environment, improve general volatile fatty acid
Amount improves propionic acid content, reduces second/third ratio, reduces the concentration of ammoniacal nitrogen, improve lumen fermentation effect, improve nutriment
Effective use.Meanwhile the present invention can be improved intestine of ruminants function, improve the digestion and absorption of nutriment, and then improve
Feed conversion rate, improves the daily gain of beef cattle, reduces feedstuff-meat ratio, improves the production performance of beef cattle mutton sheep, and effect reaches or excellent
In the effect of coban.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (13)
1. a kind of beef cattle, mutton sheep plant essential oil composition, which is characterized in that the raw material including following parts by weight: fennel oil 1-8
The mixture of part, 1-15 parts of cinnamic acid and the carvacrol and Thymol that are handled through rumen bypass, the perfume (or spice) of the rumen bypass processing
The mixture of celery phenol and Thymol includes 1-8 parts of carvacrol, 1-8 parts of Thymol and 10-40 parts of rumen bypass carrier.
2. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 1, which is characterized in that the fennel oil is
2-5 parts by weight, cinnamic acid are 6-10 parts by weight, and carvacrol is 3-5 parts by weight, and Thymol is 3-5 parts by weight.
3. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 1, which is characterized in that the rumen bypass is used
Carrier is saturated fatty acid；In the saturated fatty acid, including C16-C18 saturated fatty acid, the content of C16-C18 saturated fatty acid
It is 70% or more of saturated fatty acid；And/or the rumen bypass is selected from stearic acid, stearate, animal or plant with carrier
The mixing of one or more of hydrogenated fatty acid, fatty alcohols or acrylic resin IV.
4. a kind of any one of -3 beef cattles, mutton sheep plant essential oil composition according to claim 1, which is characterized in that also wrap
Include following parts by weight of component: 1-20 parts and adsorbent 10-40 parts of coating carrier.
5. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 4, which is characterized in that further include solvent 30-
60 parts by weight.
6. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 5, which is characterized in that the solvent is water.
7. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 6, which is characterized in that the coating carrier
Including methylcellulose and yellow mustard glue, the parts by weight of methylcellulose are 0.5-10 parts, and the parts by weight of yellow mustard glue are 0.5-10 parts.
8. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 7, which is characterized in that the Methyl cellulose
Element mixing one or more of in hydroxymethyl cellulose, sodium carboxymethylcellulose and sodium alginate.
9. a kind of beef cattle, mutton sheep plant essential oil composition according to claim 7, which is characterized in that the adsorbent is
White carbon black.
10. the preparation method of a kind of a kind of any one of claim 1-3 beef cattle, mutton sheep plant essential oil composition, special
Sign is, comprising the following steps: carvacrol and Thymol are done into rumen bypass coating with carrier with rumen bypass, obtained product with
Fennel oil and cinnamic acid are uniformly mixed, and obtain beef cattle, mutton sheep plant essential oil composition.
11. the preparation method of a kind of any one of claim 5-9 beef cattle, mutton sheep plant essential oil composition, feature exist
In, comprising the following steps: coating carrier is dissolved in solvent, fennel oil and cinnamic acid is added, is uniformly mixed, adds adsorbent
Absorption, obtains the first mixture；Carvacrol and Thymol are done into rumen bypass coating with rumen bypass with carrier, obtain the second mixing
Object；First mixture and the second mixture are mixed, beef cattle, mutton sheep plant essential oil composition are obtained.
12. according to claim 11 a kind of beef cattle, mutton sheep plant essential oil composition preparation method, which is characterized in that
Carvacrol and Thymol are done into the specific method of rumen bypass coating the following steps are included: rumen bypass is used with rumen bypass with carrier
Carrier is heated to melt, and carvacrol and Thymol are added according to the ratio, mixes, dry later, cooling.
13. the described in any item beef cattles of claim 1-9, mutton sheep are preparing cattle feed or mutton sheep feeding with plant essential oil composition
Application in material.
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| CN109043155A (en) * | 2018-07-24 | 2018-12-21 | 沈徽霞 | A kind of preparation method of the meat sheep feed additive instead of antibiotic |
| CN109527262A (en) * | 2018-12-04 | 2019-03-29 | 广东省农业科学院动物科学研究所 | Fat or oil composition and chicken feed |
| CN109549001A (en) * | 2018-12-26 | 2019-04-02 | 无锡正大生物股份有限公司 | A kind of suckling piglet nanometer coating plants essential oil and preparation method thereof |
| CN109645241A (en) * | 2019-02-26 | 2019-04-19 | 武汉华扬动物药业有限责任公司 | A kind of plants essential oil feed addictive and its preparation method and application |
| CN110201035B (en) * | 2019-06-21 | 2021-08-24 | 辽宁菲迪饲料科技有限责任公司 | Plant essential oil composition for poultry and preparation method and application thereof |
| CN112931720A (en) * | 2021-03-04 | 2021-06-11 | 安佑生物科技集团股份有限公司 | Feed additive for improving salpingitis of laying fowls, preparation method and application thereof |
| CN112998146A (en) * | 2021-04-23 | 2021-06-22 | 成都大帝汉克生物科技有限公司 | Regulator for promoting intestinal health of ruminant |
| CN113892561A (en) * | 2021-10-27 | 2022-01-07 | 潍坊加易加生物科技有限公司 | Slow-release feed additive for pigs and poultry and preparation method and application thereof |
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| PL2871973T3 (en) * | 2012-07-12 | 2019-02-28 | Novus International Inc. | Matrix and layer compositions for protection of bioactives |
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Effective date of registration: 20190802 Address after: 125000 Xingcheng Binhai Economic Zone, Liaoning, Huludao Patentee after: Liaoning Feidi Feed Science and Technology Co., Ltd. Address before: 100085 Beijing Haidian District Shangdi Information Road A 28 Keshi Building B Block 05A-2 Patentee before: Liu Chunhai |