CN106963706A - A kind of eye-care compositions and medicine and eye-care product comprising said composition - Google Patents
A kind of eye-care compositions and medicine and eye-care product comprising said composition Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of eye-care compositions, the component of following parts by weight is included：0.1 2 parts of tuberose extract, 0.1 2 parts of European horse-chestnut seed extract, 0.1 4 parts of coffee berry extract, 0.1 2 parts of tocopherol phosphate sodium, 5 0.001 0.01 parts of acetyl group tetrapeptide.Eye-care compositions of the present invention, each composition plays a role jointly, the reason for livid ring around eye, pouch and eye wrinkle-removing for causing eye aesthetic problem, remotivate the skin blood circulatory system and skin collagen synthesis, make eye contour recover script shape and the colour of skin, build evenly, more smooth, brighter, younger appearance；Meanwhile, invention additionally discloses a kind of medicine containing the eye-care compositions or eye-care product, different application targets can be directed to, improves and reduce livid ring around eye, pouch and the eye wrinkle-removing of influence eye aesthetic problem.
Description
Technical field
The present invention relates to a kind of composition, especially a kind of eye-care compositions and medicine and eye comprising said composition
Portion's nursing product.
Background technology
Eye profile is a unique region, and it is different from other positions of face.Skin around eyes is very tender
Weak, thickness is probably 1st/1 to five/3rds of other area skin thickness on the face, therefore is highly susceptible to external rings
The stimulation and influence of the pressure of border and body interior；Moreover, originally slim and frahile blood and lymphatic circulation are even more meeting with year
The increase in age and it is more weak and weary.Lymphatic Circulation and blood circulation become slower, and blood backflow is not enough so that skin color is more near the eyes
It is deep, while hemochrome may be caused to be accumulated in connective tissue, form livid ring around eye.As time go on, weak skin corium is gradually
Supplement and the support of collagen and elastin laminin are gradually lost, skin around eyes organizational slack can cause eyelid to become edema,
The wrinkle of crow's feet and palpebra inferior starts to occur.In addition to age factor, blink This move can also aggravate the evil of wrinkle near the eyes
Change.In addition, same weak epidermis can also make the thickness of water adipose membrane decline, the water loss speed of skin near the eyes is accelerated,
Skin lacks elasticity near the eyes.So, livid ring around eye, pouch, eyelid relaxation are often accompanied with crow's foot.
So-called livid ring around eye are exactly dark the presented outward appearance of eyelid color at eye socket position.Livid ring around eye and the color of eyelid in itself
The factors such as vascular flow color and light projecting direction in plain number, eyelid are relevant.Because the skin thickness of eyelid is complete
Body most thin place, so the pigment of skin or subcutaneous blood flow color are all easily reflected in eyelid surface.In addition when light is thrown
When penetrating, shade can be presented in the back of the body recess of protrusion, therefore the position seems just slightly dark.Similarly, the back of the body recess below pouch
Also shade can be presented.
The reason for livid ring around eye are formed is roughly divided into three kinds：Genotype livid ring around eye, pigment type livid ring around eye and vascular type livid ring around eye.
The black-eyed congenital comparison of skin near the eyes of genotype is plump, or the pigment accumulated in around eyelid is heavier, so ash is presented
The livid ring around eye of color.In general, genotypical livid ring around eye are difficult to desalinate it by smearing eye cream, only pass through the color make-ups such as foundation emulsion
Product are covered.Pigment type livid ring around eye are produced because melanin is generated with being metabolized incomplete.The skin of circumference of eyes is especially fragile, and it is thick
Degree only has 1st/1 to five/3rds of the other position skin of face, along with eye skin grease body of gland is less in itself, from
The naturally moist film that facial skin possesses so also just is lacked, so eye is easiest to go wrong.In strong Exposure to Sunlight illumination
Under, fragile eye skin can be easier to be attacked, and cause pigment aggravation calm, and the dark brown and brownish black of formation color spot type is black
Eyelet.Pigment type livid ring around eye are solved, first have to accomplish to prevent solar exposure, adhere to using suncream and parasols, next to that making
With the eyeware products and solution for lenses and contact lenses containing whitening composition.Vascular type livid ring around eye are because caused by capillary blood delay.Part blood
It can be oozed out from capillary, and accumulate in circumference of eyes.There is the mechanism of these excess bloods of special oxidation in human body, made by enzyme
With these red blood cells are destroyed, hemochrome is included.It can change au bleu to purple after hemochrome is destroyed, and in relatively thin eye
Become apparent upon under surrounding skin.Here it is the black-eyed most common origin cause of formation around eyes.For vascular type livid ring around eye, need
Promote blood microcirculation, enhancing capillary structure and regulation capillary permeability, accelerated decomposition hematogenous pigment.
Pouch is the skin around the unnecessary moisture of the not good accumulation of eye fatigue, aging, long-term microcirculation and fat, eye socket
Elasticity reduction, eye part skin relaxation, subcutaneous fat move down the satchel protruded in inferior orbit formation.Pouch and livid ring around eye usually by
Inflammation triggers.Ultraviolet, the oxidation of free radical, pressure, fatigue and allergy can all trigger inflammation.Inflammation causes fine vascular
Sepage, is deposited in below eye.Generally, body automatically can reabsorb hydrops and go back, and local edema is also just therewith
Disappear.But, if without ancillary method, this process often continues several all times.Caused by inflammation and sepage
Outside temporary edema, aging can cause eye permanent pouch formed below.With advancing age, eye skin can be gradually
Thinning to follow the string, subcutaneous fat accumulation makes skin below eye protrude and form pouch.It is special that permanent pouch needs
Nursing could allow skin to recover elasticity, or try to reduce the subcutaneous fat accumulation below eye.
The formation of eye wrinkle-removing is primarily due to epidermal tissue and dries thinning, skin corium collagen and elastic fibers benefit
Fill not enough and lose mesh-supported power.Skin follows the string, and is just no longer restored after being extruded, so as to form skin sagging, production
Raw wrinkle.If the function of sebaceous glands declines, sebum secretion is reduced, and sebum film is difficult to be formed, and the moisture of cuticula will be easy
It is lost in, skin is become drying, be easier to produce small microgroove.Secondly, eye part skin is influenceed by external environment, forms free
Free radical, free radical destruction normal cell membrane tissue in collagen, elastin laminin, oxidative cell and form microgroove, wrinkle.
The content of the invention
Based on this, provided it is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art a kind of gentle, safety,
Effective eye-care compositions.
To achieve the above object, the technical solution used in the present invention is：A kind of eye-care compositions, comprising following heavy
Measure the component of part：0.1-2 parts of tuberose extract, 0.1-2 parts of European horse-chestnut seed extract, 0.1-4 parts of coffee berry extract,
0.1-2 parts of tocopherol phosphate sodium, 0.001-0.01 parts of acetyl group tetrapeptide -5.
Eye-care compositions of the present invention pay close attention to two key points of eye skin：Eyelid and canthus, for causing eye
The major reason of the livid ring around eye of aesthetic problem, pouch and eye wrinkle-removing, remotivates the skin blood circulatory system and skin collagen
Albumen is synthesized, and is promoted blood microcirculation and lymph row to lead, is strengthened capillary structure, reduce capillary permeability, reduce oedema
Swollen with adipose tissue, accelerate cellulite to decompose, remove oxidized hemochrome, reduce wrinkle, eye contour is recovered originally
Shape and the colour of skin, build evenly, more smooth, brighter, younger appearance.
Tuberose (POLIANTHES TUBEROSA) extract is water-soluble active thing, with skin irritatin of releiving, is highlighted
The colour of skin dispels livid ring around eye, the skin that compacts and eliminates edema and the effect of crow's feet.Tuberose extract of the present invention can directly from
Market purchase gained, such as buy in the trade name InitialE [PT+TMG] of NAOLYS companies product.Flow over time
Die, weak skin corium loses supplement and the support of collagen and elastin laminin gradually, circumference of eyes skin becomes not bullet
Property, it is stiff, the wrinkle of crow's feet and palpebra inferior starts to occur；In addition to age factor, blink This move can also aggravate near the eyes
The deterioration of wrinkle；Skin around eyes organizational slack, can cause eyelid to become edema.Skin around eyes contains substantial amounts of fertilizer
Maxicell, make near the eyes skin do not tolerate stimulation more, it is easier to allergy, may make it that skin reddens near the eyes；And it is originally slim and frahile
Blood and lymphatic circulation are even more can be more weak and weary with the increase at age, also results in Lymphatic Circulation and blood circulation becomes
Obtain slower, blood backflow is not enough so that skin color is deeper near the eyes, while hemochrome may be caused to be accumulated in connective tissue,
Form livid ring around eye.Tuberose extract improves and recovered corium layer function by promoting fiber to synthesize, and makes skin more bullet near the eyes
Property；It can also suppress inflammation, skin irritatin of releiving, and exclude toxin, strengthen skin resistance, recover the microcirculqtory system of skin,
The shape and the colour of skin for eye contour is recovered script more become clear.
European horse-chestnut seed extract is water miscible brown ceramic powder, seven leaf haemolysis saponin content >=90%, with water resistant
It is swollen, impervious go out, effect of protection blood vessel and oxidation and removing free radicals, European horse-chestnut seed extract of the present invention can be with
Directly purchase gained, such as buys in Sabinsa Corporation trade name90% product.Horse chestnut
Saponin(e stimulates circulation, so as to provide various nutrition for skin, take away metabolite, accelerates skin metabolism, reaches and change
Low and deep matt, the reduction microgroove of kind elasticity of skin, improvement skin, improvement are dried coarse, reduction fat metabolism Product bulk, improved
Skin senescence and sub-health state；Ba 2672 can suppress destroy venous structures integrality enzyme (such as Collagenase,
Hyaluronidase, gst enzyme and elastoser etc.) activity, maintaining healthy blood vessel structure balance and blood circulation,
The permeability of capillary is reduced, improves and reduce the appearance of red blood silk, hence it is evident that improves the eye caused by microcirculation is not smooth and floats
It is swollen, for because the pouch that fat accumulation is produced also has certain effect；Ba 2672 can be stored up by suppressing leucocyte, living
Change leucocyte, help its phagocytosis to inflammatory factors such as antihistamines, eliminate the inflammatory symptoms such as oedema, promote wound healing, help extensive
The balance of multiple blood vessel structure, reduces the permeability of blood vessel, and maintains the integrality of venous structures and the tonicity (normal forces of blood vessel
Degree and tension force)；Ba 2672 has certain to the oxidation resistant effect of Green Tea Extract, repairs capillary wall, safeguards capillary
The integrality of wall；Ba 2672 improves fibroblast convergent force so that dermostenosis, so as to improve the skin of wrinkle etc
Skin state, makes skin close and flexible.
Coffee berry extract is the cyclodextrin wrappage of coffee bean extract, with good water solubility, convenient to make up
Applied in product.Caffeine, which has, to be reduced edema, remove pouch and reduces black-eyed effect.Coffee berry extract of the present invention can
Directly to buy gained, such as buy in the Cyclosystem of I.R.A.Istituto Ricerche Applicate companiesCaffeina 50%, contains 50% caffeine.From medically saying, cellulite is the chaotic one kind of microcirculation
Basic reflection, it causes the destruction of human body skin adipose tissue.Two kinds of different effects must be possessed by removing the composition of cellulite：
Lipolytic effect and stimulation blood vessel microcirculation functions, and caffeine exactly works in terms of solution fat and vascular stimulation two.
Caffeine assigns solution fat effect, stimulates solution fat by the effect on cAMP (CAMP) level, decomposes triglyceride；
There are vasoconstrictive properties blood vessel can be made to diminish for it simultaneously, to reduce the appearance of edema and pouch；The diuretic property of caffeine makes
It stimulates circulation while edema is reduced, and reduces livid ring around eye.Therefore, caffeine is from terms of solution fat and vascular stimulation two
Effect.
Tocopherol phosphate sodium is a kind of watermiscible vitamin E, has prevention and improves near the eyes that the colour of skin is uneven, blue brown is black
The effect of eyelet.The tocopherol phosphate sodium that skin is absorbed can be in skin under the catalysis of phosphatase, and rapid hydrolysis is
Active tocopherol, and then the damaging action of active oxygen is protected the skin from, improve eyelid and eye caused by light inflammation
Rubescent and inflammation below eyelid.Tocopherol phosphate sodium can promote to remove the gene expression of the enzyme of hematogenous pigment, decompose and clear
Remove due to the hematogenous pigment that blood microcirculation is bad and gathers, double pupils is more become clear.
Acetyl group tetrapeptide -5 is the artificial synthesized tetrapeptide with antioedematous effect, and it can prevent the formation of pouch and subtract
The pouch of small swelling.A main cause for forming pouch is the accumulation of moisture, is generally termed palpebral edema.Lymphatic Circulation is not smooth
It is the main cause for causing moisture to accumulate to the continuous enhancing of capillary permeability with moisture.Acetyl group tetrapeptide, which has, improves blood
The antihypertensive function and suppression vascular permeability of circulation.The crosslinking of collagen is another main original of pouch formation
Cause, saccharification reaction of the acetyl group tetrapeptide to collagen has rejection ability.
Preferably, the eye-care compositions also include at least one in glycosyl hesperidin, niacinamide, rhizobium glue
Kind.
It is highly preferred that when the eye-care compositions include glycosyl hesperidin, the parts by weight of glycosyl hesperidin are
0.1-1 parts；When the eye-care compositions include niacinamide, the parts by weight of niacinamide are 0.1-5 parts；When eye shield
When managing composition comprising rhizobium glue, the parts by weight of rhizobium glue are 0.1-1 parts.
Glycosyl hesperidin is that the hesperidin that native starch glucose is originated with orange peel obtains a kind of high through glycosylation reaction
Water miscible alpha-glycosyl hesperidin.When the cosmetics containing glycosyl hesperidin are applied on skin, one kind is naturally occurring in
Glycosidase in skin can slowly hydrolyze glycosyl hesperidin and discharge hesperidin.During hesperidin is a kind of biological flavone, orange peel
Active component, the microcirculation of skin can be promoted, make fragility capillary become strong and reduce their permeability, dispel
Except livid ring around eye, the colour of skin caused by the poor circulation due to skin are intensely dark and skin turgor, skin health is reappeared honorable.
Niacinamide (vitamin B3) is a kind of water soluble vitamin, and vitamin B3 has prominent effect in terms of anti-aging.
A variety of researchs show that vitamin B3 has the effect of activation collagen synthesis and strengthens the barrier function of skin, can protect
Skin from solar UV injury and prevent skin pigment excessively calm.Vitamin B3 by activating collagen synthesis,
Help to strengthen the construction of blood vessel basement layer, help to safeguard by playing a protective role to blood vessel or recover normal blood stream
It is dynamic.
Rhizobium glue is the side chain polysaccharide formed by fermentation by the wheat bran culture medium containing rhizobium, and it is powder
Shape, the dalton of molecular weight 800,000, the sequential cells being made up of following ingredients：6 neutral sugars (3 grapes of pyranose form
Glycan molecule and 3 galactose molecules) and 1 electrically charged glucuronic acid molecule, and acetyl group and acetone acidic group are carried, because
This turns into the polysaccharide with electric charge.Rhizobium glue Vitamin K, reduction rubefaction phenomenon, moisturizing immediately and can be tightened up
Skin.Preferably, when the parts by weight of the rhizobium glue are 0.5-1 parts, there is the eye-care compositions instant eye to protect
Manage effect.
Eye-care compositions of the present invention, are used for the focus difference or formulation difference of eye problems
Various combination, in above-mentioned parts by weight and weight ratio, can make for specific purpose eye-care compositions nursing efficacy and into
Originally optimum balance is reached.
Meanwhile, the present invention also provides a kind of medicine containing above-mentioned eye-care compositions or eye-care product.This is sent out
Bright composition is used for medicine and cosmetics so that medicine and cosmetics, which have to improve and reduce, causes the black of eye aesthetic problem
Eyelet, pouch and eye wrinkle-removing.
Preferably, the eye-care product also include auxiliary material, and auxiliary material is referred to currently used for the customary adjuvant in cosmetics,
Those skilled in the art can select the auxiliary material of Optimum Contents according to prior art and the formulation of cosmetics, purposes etc., as long as institute
The auxiliary material of selection not for fear of the desired function of the present composition just.Cosmetic can be《It is former using cosmetics
Expect Names Catalogue》Find.
It is highly preferred that the auxiliary material be preservative, chelating agent, essence, grease, NMF, thickener, surfactant,
At least one of emulsifying agent, colouring agent, antioxidant, penetration-assisting agent, skin sense conditioning agent；
When the eye-care product include preservative, the preservative is Form aldehyde release body class, parabens, halogen
Plain class, quaternary ammonium salt, organic acid, alcohols at least one of the preservatives；Preferably, the preservative is organic acid anti-corrosion
Agent or alcohols preservative；
When the eye-care product include NMF, the NMF is glycerine, propane diols, butanediol, 1,2- penta 2
In alcohol, 1,2- hexylene glycols, pyrrolidone sodium carboxylate, 2-pyrrolidone-5-carboxylic acid's potassium, Sodium Hyaluronate, carbohydrate, polyethylene glycol at least
It is a kind of；
When the eye-care product include thickener when, the thickener be cellulose, xanthans, carragheen, gellan gum,
At least one of pectin, locust bean gum, carbomer, polyacrylic acid analog copolymer, Magnesiumaluminumsilicate, lithium magnesium silicate, sodium magnesium silicate；
When the eye-care product include antioxidant, the antioxidant is tocopherol (vitamin E), tocopherol second
At least one of acid esters, Butylated Hydroxytoluene, parahydroxyacet-ophenone；
When the eye-care product include penetration-assisting agent, the penetration-assisting agent is Laurocapram, ethoxydiglycol, gathers sweet
At least one of the oily acid esters of -10,20 carbon two, the acid esters of 14 carbon two, glycerine.
Preservative, NMF, thickener, antioxidant and the penetration-assisting agent of eye-care product of the present invention are included but not limited
In the preferred material.
Preferably, the eye-care product are the resident product of liquid, gel shape, emulsion form or cream shape.From using
Aspect of performance considers that the cosmetics are more preferably cream shape.The preparation preparation method of the eye-care product can be by ability
Field technique personnel are selected according to conventional methods.
Relative to prior art, beneficial effects of the present invention are：
(1) eye-care compositions provided by the present invention, each composition plays a role jointly, for causing eye is attractive in appearance to ask
The major reason of the livid ring around eye of topic, pouch and eye wrinkle-removing, remotivates the skin blood circulatory system and skin collagen is closed
Into promotion blood microcirculation and lymph row lead, and strengthen capillary structure, reduce capillary permeability, reduce oedema and fat
Tissue swells, and accelerates cellulite to decompose, and removes oxidized hemochrome, reduces wrinkle, eye contour is recovered the shape of script
And the colour of skin, build evenly, more smooth, brighter, younger appearance；
(2) by the way that the eye-care compositions of the present invention are made into different State of cosmetics for different application targets,
It can improve and reduce livid ring around eye, pouch and the eye wrinkle-removing of influence eye aesthetic problem.
Brief description of the drawings
Fig. 1 is to remove livid ring around eye effect assessment statistical chart.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.Tuberose extract in embodiment is to buy the trade name InitialE [PT+ in NAOLYS companies
TMG] product；European horse-chestnut seed extract is to buy in Sabinsa Corporation trade name
90% product；Coffee berry extract is to buy in I.R.A.Istituto Ricerche Applicate companies
CyclosystemCaffeina 50% product.
Embodiment 1
A kind of embodiment of eye-care compositions of the present invention, eye-care compositions described in the present embodiment include with
The composition of lower parts by weight：0.1 part of tuberose extract, 0.1 part of European horse-chestnut seed extract, 0.1 part of coffee berry extract, life
Educate 1 part of 2 parts of phenol sodium phosphate, 0.001 part of acetyl group tetrapeptide -5 and glycosyl hesperidin.
The preparation method of eye-care compositions described in the present embodiment is：First disperse coffee berry extract with 50 parts of water, stir
Tocopherol phosphate sodium is added after mixing uniformly, is stirred, tuberose extract, European horse-chestnut seed is eventually adding and extracts
Thing, acetyl group tetrapeptide -5, glycosyl hesperidin and residual share, stir as eye-care compositions.
Embodiment 2
A kind of embodiment of eye-care compositions of the present invention, eye-care compositions described in the present embodiment are comprising following heavy
Measure the component of part：0.1 part of tuberose extract, 2 parts of European horse-chestnut seed extract, 4 parts of coffee berry extract, tocopherol phosphoric acid
5 parts of 0.1 part of ester sodium, 0.01 part of acetyl group tetrapeptide -5 and niacinamide.
The preparation method of eye-care compositions described in the present embodiment is：First disperse coffee berry extract with 50 parts of water, stir
Tocopherol phosphate sodium is added after mixing uniformly, is stirred, tuberose extract, European horse-chestnut seed is eventually adding and extracts
Thing, acetyl group tetrapeptide -5, niacinamide and residual share, stir as eye-care compositions.
Embodiment 3
A kind of embodiment of eye-care compositions of the present invention, eye-care compositions described in the present embodiment are comprising following heavy
Measure the component of part：2 parts of tuberose extract, 0.1 part of European horse-chestnut seed extract, 0.1 part of coffee berry extract, tocopherol phosphorus
0.1 part of 0.1 part of acid esters sodium, 0.01 part of acetyl group tetrapeptide -5,5 parts of niacinamide and rhizobium glue.
The preparation method of eye-care compositions described in the present embodiment is：First disperse rhizobium glue with 50 parts of water, it is uniform after
Coffee berry extract is added, tocopherol phosphate sodium is added after stirring, is stirred, tuberose extraction is eventually adding
Thing, European horse-chestnut seed extract, acetyl group tetrapeptide -5, the water of niacinamide and residual share, stir as eye-care
Composition.
Embodiment 4
A kind of embodiment of eye-care compositions of the present invention, eye-care compositions described in the present embodiment are comprising following heavy
Measure the component of part：0.1 part of tuberose extract, 0.1 part of European horse-chestnut seed extract, 0.1 part of coffee berry extract, tocopherol
1 part of 0.2 part of sodium phosphate, 0.001 part of acetyl group tetrapeptide -5,0.1 part of niacinamide and rhizobium glue.
The preparation method of eye-care compositions described in the present embodiment is：Rhizobium glue is first disperseed with 50 parts of water, uniformly
Coffee berry extract is added afterwards, is continued to be stirring evenly and then adding into tocopherol phosphate sodium, is stirred, is eventually adding tuberose and carries
The water of thing, European horse-chestnut seed extract, acetyl group tetrapeptide -5, niacinamide and residual share is taken, is stirred as eye shield
Manage composition.
Embodiment 5
A kind of embodiment of eye-care compositions of the present invention, eye-care compositions described in the present embodiment are comprising following heavy
Measure the component of part：1 part of tuberose extract, 1 part of European horse-chestnut seed extract, 4 parts of coffee berry extract, tocopherol phosphate
0.5 part of 1 part of sodium, 0.005 part of acetyl group tetrapeptide -5,0.1 part of glycosyl hesperidin, 3 parts of niacinamide and rhizobium glue.
The preparation method of eye-care compositions described in the present embodiment is：First disperse rhizobium glue with 80 parts of water, it is uniform after
Coffee berry extract is added, tocopherol phosphate sodium is added after stirring, is stirred, tuberose extraction is eventually adding
Thing, European horse-chestnut seed extract, acetyl group tetrapeptide -5, glycosyl hesperidin and niacinamide, stir as eye-care group
Compound.
Embodiment 6 goes the preparation of livid ring around eye frost
A kind of embodiment of eye-care product of the present invention, eye-care product described in the present embodiment is remove livid ring around eye frost, and it contains
There are eye-care compositions described in embodiment 1.Go the composition of livid ring around eye frost as shown in table 1 described in the present embodiment.
Table 1 removes livid ring around eye frost composition
The preparation technology for removing livid ring around eye frost of the present embodiment is as follows：
1) by No. 1-No. 5 raw material agitating and heatings of raw material serial number in table 1, he uses reserved 5 parts of No. 1 raw material, and 80 DEG C-85
DEG C insulated and stirred 20 minutes, this is 1. phase；
2) by No. 6-No. 10 raw material agitating and heatings of raw material serial number in table 1,80 DEG C-85 DEG C insulated and stirreds 10 minutes,
As 2. phase；
3) emulsification pot, homogeneous 5 minutes, 80 DEG C -85 DEG C insulated and stirreds 15 minutes, cooling 1. mutually and 2. mutually will successively be added
Cooling, as 3. phase；
4) add and disperse No. 13 raw materials in advance with 5 parts of No. 1 raw materials, No. 14 raw materials are added after stirring, continue to stir
Uniformly, No. 11, No. 12, No. 15, No. 16 and No. 17 raw materials are eventually adding, stir i.e. 4. phase.
5) it will 4. be added in 40 DEG C of 3. phase, stir 15 minutes, filtering and discharging obtains 5. phase, as remove livid ring around eye frost.
Embodiment 7 goes the preparation of eyelid cream
A kind of embodiment of eye-care product of the present invention, eye-care product described in the present embodiment is remove eyelid cream, and it contains
Eye-care compositions described in embodiment 2.Go the composition of eyelid cream as shown in table 2 described in the present embodiment.
Table 2 goes eyelid cream to constitute
The preparation technology for removing eyelid cream of the present embodiment is as follows：
1) by No. 1-No. 5 raw material agitating and heatings of raw material serial number in table 2, he uses reserved 10 parts of No. 1 raw material, 80 DEG C-
85 DEG C of insulated and stirreds 20 minutes, this is 1. phase；
2) by No. 6-No. 10 raw material agitating and heatings of raw material serial number in table 2,80 DEG C-85 DEG C insulated and stirreds 10 minutes,
As 2. phase；
3) emulsification pot, homogeneous 5 minutes, 80 DEG C -85 DEG C insulated and stirreds 15 minutes, cooling 1. mutually and 2. mutually will successively be added
Cooling, as 3. phase；
4) add and disperse No. 13 raw materials in advance with 10 parts of No. 1 raw materials, No. 14 raw materials are added after stirring, continue to stir
Uniformly, No. 11, No. 12, No. 15, No. 16 and No. 17 raw materials are eventually adding, stir i.e. 4. phase.
5) it will 4. be added in 40 DEG C of 3. phase, stir 15 minutes, filtering and discharging obtains 5. phase, as removes eyelid cream.
The preparation of the Wrinkle removing eye cream of embodiment 8
A kind of embodiment of eye-care product of the present invention, eye-care product described in the present embodiment are Wrinkle removing eye cream, and it contains
Eye-care compositions described in embodiment 3.The composition of Wrinkle removing eye cream described in the present embodiment is as shown in table 3.
The Wrinkle removing eye cream of table 3 is constituted
| Sequence number | Material name | Parts by weight/part | Application target (role) |
| 1 | Water | 73.99 | Solvent |
| 2 | Xanthan gum | 0.20 | Thickener |
| 3 | Rhizobium glue | 0.1 | Skin conditioning agent |
| 4 | Glycerine | 3.0 | NMF |
| 5 | 1,2- hexylene glycols | 0.40 | NMF |
| 6 | Parahydroxyacet-ophenone | 0.50 | Antioxidant |
| 7 | MONTANOV 68 | 2.0 | Emulsifying agent |
| 8 | Cetostearyl alcohol | 3.0 | Emulsifying agent |
| 9 | Dimethyl silicone polymer | 1.0 | Emollient |
| 10 | Parleam | 4.0 | Emollient |
| 11 | Jojoba seed oil | 4.0 | Emollient |
| 12 | Tuberose extract | 2.0 | Skin conditioning agent |
| 13 | European horse-chestnut seed extract | 0.1 | Skin conditioning agent |
| 14 | Coffee berry extract | 0.1 | Skin conditioning agent |
| 15 | Tocopherol phosphate sodium | 0.1 | Skin conditioning agent |
| 16 | Acetyl group tetrapeptide -5 | 0.01 | Skin conditioning agent |
| 17 | Niacinamide | 5.0 | Skin conditioning agent |
| 18 | Panthenol | 0.50 | Skin conditioning agent |
The preparation technology of the Wrinkle removing eye cream of the present embodiment is as follows：
1) No. 2 and No. 3 raw materials of raw material serial number in table 3 are sprinkled into No. 1 raw material of stirring, reserved 10 parts of No. 1 raw material he
With, stir 30 minutes, it is uniform after continuously add No. 4-No. 6, agitating and heating, 80 DEG C-85 DEG C insulated and stirreds 20 minutes, 1. this is
Phase；
2) by No. 7-No. 11 raw material agitating and heatings of raw material serial number in table 3,80 DEG C-85 DEG C insulated and stirreds 10 minutes,
As 2. phase；
3) emulsification pot, homogeneous 5 minutes, 80 DEG C -85 DEG C insulated and stirreds 15 minutes, cooling 1. mutually and 2. mutually will successively be added
Cooling, as 3. phase；
4) add and disperse No. 14 raw materials in advance with 10 parts of No. 1 raw materials, stir, No. 15 originals are added after stirring
Material, continues to stir, is eventually adding No. 12, No. 13, No. 16, No. 17 and No. 18 raw materials, and stir i.e. 4. phase.
5) it will 4. be added in 40 DEG C of 3. phase, stir 15 minutes, filtering and discharging obtains 5. phase, as Wrinkle removing eye cream.
The preparation of the non-woven fabrics stress relief eye mask liquid of embodiment 9
A kind of embodiment of eye-care product of the present invention, cosmetics described in the present embodiment are non-woven fabrics stress relief eye mask
Liquid, it contains eye-care compositions described in embodiment 4.The composition such as table of non-woven fabrics stress relief eye mask liquid described in the present embodiment
Shown in 4.
The non-woven fabrics stress relief eye mask liquid of table 4 is constituted
| Sequence number | Material name | Parts by weight/part | Application target (role) |
| 1 | Water | 88.99 | Solvent |
| 2 | Rhizobium glue | 1.0 | Skin conditioning agent |
| 3 | Glycerine | 3.0 | NMF |
| 4 | 1,2- hexylene glycols | 0.40 | NMF |
| 5 | Parahydroxyacet-ophenone | 0.50 | Antioxidant |
| 6 | Erythrite | 5.0 | NMF |
| 7 | Tuberose extract | 0.10 | Skin conditioning agent |
| 8 | European horse-chestnut seed extract | 0.10 | Skin conditioning agent |
| 9 | Coffee berry extract | 0.10 | Skin conditioning agent |
| 10 | Tocopherol phosphate sodium | 0.20 | Skin conditioning agent |
| 11 | Acetyl group tetrapeptide -5 | 0.0010 | Skin conditioning agent |
| 12 | Niacinamide | 0.1 | Skin conditioning agent |
| 13 | Panthenol | 0.50 | Skin conditioning agent |
The preparation technology of the non-woven fabrics stress relief eye mask liquid of the present embodiment is as follows：
1) No. 2 raw materials stirring in table 4 is added in No. 1 raw material, stirred, add No. 3-No. 6 raw materials, stirring
Heating, 70 DEG C -75 DEG C insulated and stirreds 30 minutes, this is 1. phase；
2) 1. will mutually it cool, No. 7-No. 13 raw materials of raw material serial number in 40 DEG C of addition tables 4 stir, filtered
Discharging, obtains 2. phase, as non-woven fabrics stress relief eye mask liquid.
The compliance test result of embodiment 10 example
(1) test case 1 is applied
Method：54 female volunteers, the age, average age 40 years old had obvious microcirculation not from 35 years old to 50 years old
The vascular type livid ring around eye freely caused.Livid ring around eye frost, once in the morning and once at night, 56 days by a definite date are removed using the embodiment of the present invention 6.Survey
Examination process carries out survey to volunteer, is tested color intensity and the face of the front and rear livid ring around eye skin of personnel's self-contrast treatment
Product, to going livid ring around eye effect to give a mark.0 point indicates no positive effect, and 1 point of expression is effective, and 2 points indicate positive effect, 3
Divide and indicate clearly effect.In 0 day, 14 days, 28 days and 56 days records appraisal result, statistical result was as shown in Figure 1.
From Fig. 1 statistical result can be seen that volunteer using the embodiment of the present invention 6 go livid ring around eye frost, 14 days timeliness
It is effective (average 1.3) that fruit, which is evaluated, and effect assessment is that have substantially when effect assessment is effective (average 1.7) 56 days at 28 days
Effect (average 2.1).
(2) test case 2 is applied
Method：15 female volunteers, the age, average age 46 years old had obvious microcirculation not from 40 years old to 60 years old
The pouch freely caused.Using the eyelid cream that goes of the embodiment of the present invention 7, once in the morning and once at night, continue 56 days.Test process is to will
Hope person carries out survey, pouch area before and after the nursing of personnel's self-contrast is tested, to going pouch effect to give a mark.0 point
No positive effect is indicated, 1 point of expression is effective, and 2 points indicate positive effect, and 3 points indicate clearly effect.0 day, 14
My god, 28 days and 56 days records appraisal results, statistical result is as shown in table 5.
Table 5 goes pouch effect volunteer self-assessment to count
Go eyelid cream of the volunteer using the embodiment of the present invention 6 is can be seen that from the statistical result of table 5,73% at 14 days
Volunteer evaluate be effective, at 28 days 87% volunteer evaluate is effective, at 56 days 93% volunteer evaluate is
It is effective.
(3) test case 3 is applied
Method：20 female volunteers, the age, average age 50 years old used the embodiment of the present invention 8 from 40 years old to 65 years old
Wrinkle removing eye cream, once in the morning and once at night, continues 30 days.Survey is carried out to volunteer at the end of test, personnel are tested certainly
I evaluates the improvement situation of the front and rear eye part skin aridity of nursing, roughness, wrinkle quantity and wrinkle depth, counts each project
Confirm the improved number of tested volunteer, statistical result is as shown in table 6.
The Wrinkle removing eye cream volunteer self-assessment of table 6 is counted
| Test event | Aridity improves | Roughness improves | Wrinkle quantity is reduced | Wrinkle depth shoals |
| Number | 17 | 17 | 16 | 15 |
The Wrinkle removing eye cream that tested volunteer uses the embodiment of the present invention 8,75% are can be seen that from the statistical result of table 6
(15/20) tested volunteer thinks that wrinkle depth shoals, and the tested volunteer in 80% (16/20) thinks that wrinkle quantity is reduced, 85%
(17/20) tested volunteer thinks that aridity and roughness are improved.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (8)
1. a kind of eye-care compositions, it is characterised in that include the component of following parts by weight：0.1-2 parts of tuberose extract,
0.1-2 parts of European horse-chestnut seed extract, 0.1-4 parts of coffee berry extract, 0.1-2 parts of tocopherol phosphate sodium, acetyl group four
0.001-0.01 parts of peptide -5.
2. eye-care compositions as claimed in claim 1, it is characterised in that also comprising glycosyl hesperidin, niacinamide, root nodule
At least one of bacterium glue.
3. eye-care compositions as claimed in claim 2, it is characterised in that when the eye-care compositions include glycosyl
During hesperidin, the parts by weight of glycosyl hesperidin are 0.1-1 parts；When the eye-care compositions include niacinamide, niacinamide
Parts by weight be 0.1-5 parts；When the eye-care compositions include rhizobium glue, the parts by weight of rhizobium glue are 0.1-1
Part.
4. eye-care compositions as claimed in claim 2 or claim 3, it is characterised in that the parts by weight of the tuberose extract
For 1-2 parts, the parts by weight of the niacinamide are 3-5 parts.
5. eye-care compositions as claimed in claim 2 or claim 3, it is characterised in that the parts by weight of the rhizobium glue are
0.5-1 parts.
6. the medicine or eye-care product of a kind of eye-care compositions containing described in any one of Claims 1 to 5.
7. eye-care product as claimed in claim 6, it is characterised in that the eye-care product also include auxiliary material, described auxiliary
Expect for preservative, chelating agent, essence, grease, NMF, thickener, surfactant, emulsifying agent, colouring agent, antioxidant,
At least one of penetration-assisting agent, skin sense conditioning agent；
When the eye-care product include preservative, the preservative is Form aldehyde release body class, parabens, containing halogen
Class, quaternary ammonium salt, organic acid, alcohols at least one of the preservatives；
When the eye-care product include NMF when, the NMF be glycerine, propane diols, butanediol, 1,2- pentanediols, 1,
At least one of 2- hexylene glycols, pyrrolidone sodium carboxylate, 2-pyrrolidone-5-carboxylic acid's potassium, Sodium Hyaluronate, carbohydrate, polyethylene glycol；
When the eye-care product include thickener, the thickener is cellulose, xanthans, carragheen, gellan gum, fruit
At least one of glue, locust bean gum, carbomer, polyacrylic acid analog copolymer, Magnesiumaluminumsilicate, lithium magnesium silicate, sodium magnesium silicate；
When the eye-care product include antioxidant, the antioxidant is tocopherol, tocopherol acetate, fourth hydroxyl first
At least one of benzene, parahydroxyacet-ophenone；
When the eye-care product include penetration-assisting agent when, the penetration-assisting agent be Laurocapram, ethoxydiglycol, polyglycereol-
10th, at least one of the acid esters of 20 carbon two, the acid esters of 14 carbon two, glycerine.
8. eye-care product as claimed in claim 7, it is characterised in that the eye-care product are liquid, gel shape, emulsion
The resident product of shape or cream shape.
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| CN201710163719.0A CN106963706A (en) | 2017-03-17 | 2017-03-17 | A kind of eye-care compositions and medicine and eye-care product comprising said composition |
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|---|---|---|---|
| CN201710163719.0A CN106963706A (en) | 2017-03-17 | 2017-03-17 | A kind of eye-care compositions and medicine and eye-care product comprising said composition |
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| CN201710163719.0A Pending CN106963706A (en) | 2017-03-17 | 2017-03-17 | A kind of eye-care compositions and medicine and eye-care product comprising said composition |
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| CN108478479A (en) * | 2018-04-02 | 2018-09-04 | 青岛科技大学 | Crease-resistant gel of eye containing the pterostilbene compound that can voluntarily provide weak acid environment and preparation method thereof |
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| CN110638707A (en) * | 2019-10-29 | 2020-01-03 | 浙江英树生物科技有限公司 | Eye care cream and preparation method thereof |
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| CN111544759A (en) * | 2020-04-26 | 2020-08-18 | 优微（珠海）生物科技有限公司 | Microneedle patch for removing black eye circles and preparation method thereof |
| CN112641717A (en) * | 2021-02-05 | 2021-04-13 | 东晟源研究院(广州)有限公司 | Eye-protecting cream with upper eyelid and lower eyelid for zone nursing |
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| US11160744B2 (en) | 2017-10-11 | 2021-11-02 | Showa Denko K.K. | Gel composition |
| EP3695829A4 (en) * | 2017-10-11 | 2021-07-14 | Showa Denko K.K. | Gel composition |
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| CN110179715B (en) * | 2019-06-27 | 2022-02-15 | 广州康蓓纳生物科技有限公司 | Black eye removing composition, black eye removing eye mask and preparation method thereof |
| CN110787082A (en) * | 2019-09-29 | 2020-02-14 | 广州达达眼健康管理有限公司 | Eye cell repair composition and eye care product containing same |
| CN110638707A (en) * | 2019-10-29 | 2020-01-03 | 浙江英树生物科技有限公司 | Eye care cream and preparation method thereof |
| CN111544759A (en) * | 2020-04-26 | 2020-08-18 | 优微（珠海）生物科技有限公司 | Microneedle patch for removing black eye circles and preparation method thereof |
| CN112641717A (en) * | 2021-02-05 | 2021-04-13 | 东晟源研究院(广州)有限公司 | Eye-protecting cream with upper eyelid and lower eyelid for zone nursing |
| CN112972314A (en) * | 2021-03-31 | 2021-06-18 | 科丝美诗(中国)化妆品有限公司 | Eye repair composition and preparation method and application thereof |
| CN112972314B (en) * | 2021-03-31 | 2023-04-25 | 科丝美诗(中国)化妆品有限公司 | Eye repair composition and preparation method and application thereof |
| CN117815099A (en) * | 2024-03-06 | 2024-04-05 | 珠海金肽生物科技有限公司 | Peptide-containing anti-aging and skin micro-ecological regulation composition and preparation method and application thereof |
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Application publication date: 20170721 |