CN106962640A - A kind of feed addictive and preparation method for being used to prevent and treat sucking pig roundworm disease - Google Patents
A kind of feed addictive and preparation method for being used to prevent and treat sucking pig roundworm disease Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to field of feed additive technology there is provided a kind of feed addictive and preparation method for being used to prevent and treat sucking pig roundworm disease, the feed addictive for being used to prevent and treat sucking pig roundworm disease includes following component：Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei.The feed addictive is made in the processes such as above-mentioned raw materials are cleaned, immersion, backflow purification, mixing.The feed addictive of the present invention for being used to prevent and treat sucking pig roundworm disease uses the Chinese herbal medicine formula containing aldehydes matter, and combine the Chinese herbal medicine with clearing heat and detoxicating and strengthen immunity, the problem of eliminating big drug resistance, medicament residue, toxic side effect, less effective while reaching that efficiently preventing and treating ascaris suum is sick；Meanwhile, the present invention provides a kind of preparation method for being used to prevent and treat the feed addictive of sucking pig roundworm disease, and the preparation method can fully extract the active ingredient of herbal control ascaris suum and keep greater activity.
Description
Technical field
The invention belongs to field of feed additive technology, in particular it relates to a kind of feed for being used to prevent and treat sucking pig roundworm disease
Additive and preparation method.
Background technology
Ascaris suum belongs to obligatory parasitism, and it neither parasitizes equus, does not also parasitize ruminant, and it is small that it colonizes in pig
Parasitic disease caused by intestines, fresh polypide is pale red or faint yellow, and polypide is in the thinner cylinder in middle slightly thick, two ends,
Like the large-scale nematode of earthworm shape.Male worm 15~25cm of length, tail end is bent to the outside of belly, is similar to fish hook；Female adult 20~40cm of length, worm
Body is more straight, and tail end is slightly blunt.Worm's ovum is approximate circle, yellowish-brown, and chorion is thick, by 4 in groups into outermost layer is the protein of undulate
Film.Pig has eaten infectious roundworm egg and has been infected, and roundworm egg development adult needs 50~60 days, roundworm destruction pig liver, lungs,
The institutional framework and physiological function of enteron aisle, show as the bleeding of liver small point-like and the muddy swelling of liver cell, steatosis and necrosis,
So that the densification that hepatic tissue becomes, surface is bled profusely a little.The diarrhoea of sucking pig is understood when Ascaris suum larvae is divided a word with a hyphen at the end of a line in pig body, is disappeared
Thin, anaemia, bleeding, undergrowth, and easily cause the secondary of Other diseases, serious causes sucking pig dead.When adult is parasitic
Small enteral has a large amount of roundworms, and occurs intestinal obstruction, it is seen that small intestinal mucosa has catarrhal inflammation, bleeding or ulcer.Adult is in enteron aisle
It is interior to fight for nutrition with pig, turn into the infection sources with excrement discharge.
Ascaris suum disease it is popular with it is widely distributed, it is high to sucking pig infection rate, it is pathogenic by force.Sucking pig parasitic disease must be carried out
Preventing and controlling.It is main at present that ascaris suum disease is prevented and treated using medicine, it is workable to have metrifonate, Pyrantel, levamisol
Deng, but these medicines easily trigger the resistance to the action of a drug and can be remained in body, and it is unfavorable to the healthy growth of pig.Therefore, research and develop a kind of
Preventing and treating ascaris suum is sick and has no toxic side effect, the medicine of drug residue free is field scientific research technical staff problem anxious to be resolved.
Containing abundant aldehydes matter in some Chinese herbal medicines, metabolism of the aldehydes matter to roundworm has upset effect, prevents
It grows.Therefore, the Chinese herbal medicine containing aldehydes matter is can select to treat ascaris suum disease.
The content of the invention
For defect of the prior art, present invention aim to address the medicine treatment that current preventing and treating ascaris suum disease is used
The problem of drug resistance that method is produced, medicament residue, toxic side effect big, less effective, is used to prevent and treat sucking pig roundworm disease there is provided one kind
Feed addictive, it is described be used for prevent and treat sucking pig roundworm disease feed addictive use the Chinese herbal medicine formula containing aldehydes matter,
And the medicinal herb componentses with clearing heat and detoxicating and strengthen immunity are combined, while reaching that efficiently preventing and treating ascaris suum is sick, eliminate
The problem of drug resistance, medicament residue, big toxic side effect；Meanwhile, the present invention provides a kind of feed for being used to prevent and treat sucking pig roundworm disease
The preparation method of additive, the preparation method can fully extract the active ingredient of herbal control ascaris suum and keep higher work
Property.
A kind of feed addictive for being used to prevent and treat sucking pig roundworm disease is provided according to an aspect of the present invention, it is described to be used to prevent
Controlling the feed addictive of sucking pig roundworm disease includes the component of following parts by weight：It is 6~12 parts of lotus leaf, 3~9 parts of the dried immature fruit of citron orange, pale reddish brown
5~13 parts of fourth, 7~12 parts of rhizoma woodwardiae, 7~14 parts of litchi rind, 8~12 parts of sealwort, 8~13 parts of lycopodium calvatum, tribulus terrestris 7~13
5~9 parts of part, 9~12 parts of fennel seeds and Rhizoma Arthromeritis mairei.
Preferably, the feed addictive for being used to prevent and treat sucking pig roundworm disease includes the component of following parts by weight：Lotus leaf 7
~11 parts, 6~8 parts of the dried immature fruit of citron orange, 7~11 parts of Chinese violet, 9~11 parts of rhizoma woodwardiae, 8~13 parts of litchi rind, 9~11 parts of sealwort,
6~8 parts of 9~12 parts of lycopodium calvatum, 8~11 parts of tribulus terrestris, 10~11 parts of fennel seeds and Rhizoma Arthromeritis mairei.
Preferably, the feed addictive for being used to prevent and treat sucking pig roundworm disease includes the component of following parts by weight：Lotus leaf 8
Part, 7 parts of the dried immature fruit of citron orange, 9 parts of Chinese violet, 10 parts of rhizoma woodwardiae, 9 parts of litchi rind, 10 parts of sealwort, 10 parts of lycopodium calvatum, 9 parts of tribulus terrestris,
7 parts of 10 parts of fennel seeds and Rhizoma Arthromeritis mairei.
Preferably, the feed addictive for being used to prevent and treat sucking pig roundworm disease is liquid.
Preferably, addition of the feed addictive for being used to prevent and treat sucking pig roundworm disease in the pig drinking water is 90
~130 g kgs.
There is provided the described feed addictive preparation side for being used to prevent and treat sucking pig roundworm disease according to another aspect of the present invention
Method, methods described comprises the following steps：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 2~4 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 3~5 times of weight waters respectively, soak 0.5~1.0 hour, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 50~60 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 3~6 times of weight percent methanols and 2~3 times of weight waters, it is Celsius 40~50
Under degree, refluxing extraction 5~7 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 2~3 times, finally by each filtrate
Mixing；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
Compared with prior art, the present invention has following beneficial effect：
（1）The feed addictive of the present invention for being used to prevent and treat sucking pig roundworm disease uses the Chinese herbal medicine formula containing aldehydes matter,
Wherein lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind etc. contain aldehydes matter, and metabolism of the aldehydes matter to roundworm has
Upset is acted on, and prevents it from growing.Therefore, ascaris suum disease is treated with the Chinese herbal medicine containing aldehydes matter, has significant curative effect, simultaneously
Ascaris suum disease is efficiently prevented and treated with reference to clearing heat and detoxicating and strengthen immunity Chinese herbal medicine, reaching；
（2）Drug resistance, medicament residue, toxic side effect that the present invention can eliminate conventional medication generation be big, less effective asks
Topic；
（3）Preparation method of the present invention can fully extract the active ingredient of herbal control ascaris suum and keep greater activity.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.
Embodiment 1
Being used to prevent and treat the feed addictive of sucking pig roundworm disease described in the present embodiment includes the component of following parts by weight：Lotus leaf 12
Part, 3 parts of the dried immature fruit of citron orange, 13 parts of Chinese violet, 7 parts of rhizoma woodwardiae, 14 parts of litchi rind, 8 parts of sealwort, 13 parts of lycopodium calvatum, 7 parts of tribulus terrestris,
5 parts of 12 parts of fennel seeds and Rhizoma Arthromeritis mairei.The feed addictive for being used to prevent and treat sucking pig roundworm disease is liquid；It is described to be used to prevent and treat breast
Addition of the feed addictive of ascaris suum disease in the pig drinking water is 130 g kgs.
It is used for the feed addictive preparation method for preventing and treating sucking pig roundworm disease described in the present embodiment, methods described includes following step
Suddenly：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 2 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 5 times of weight waters respectively, soak 0.5 hour, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 60 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 6 times of weight percent methanols and 2 times of weight waters, at 50 c, backflow
Extract 5 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 3 times, finally mix each filtrate；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
Embodiment 2
Being used to prevent and treat the feed addictive of sucking pig roundworm disease described in the present embodiment includes the component of following parts by weight：6 parts of lotus leaf,
9 parts of the dried immature fruit of citron orange, 5 parts of Chinese violet, 12 parts of rhizoma woodwardiae, 7 parts of litchi rind, 12 parts of sealwort, 8 parts of lycopodium calvatum, 13 parts of tribulus terrestris, fennel fruit
Fragrant 9 parts and 9 parts of Rhizoma Arthromeritis mairei.The feed addictive for being used to prevent and treat sucking pig roundworm disease is liquid；It is described to be used to prevent and treat sucking pig ascarid
Addition of the feed addictive of parasitosis in the pig drinking water is 90 g kgs.
It is used for the feed addictive preparation method for preventing and treating sucking pig roundworm disease described in the present embodiment, methods described includes following step
Suddenly：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 4 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 3 times of weight waters respectively, soak 1.0 hours, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 50 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 3 times of weight percent methanols and 3 times of weight waters, under 40 degrees Celsius, backflow
Extract 7 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 2 times, finally mix each filtrate；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
Embodiment 3
Being used to prevent and treat the feed addictive of sucking pig roundworm disease described in the present embodiment includes the component of following parts by weight：Lotus leaf 11
Part, 6 parts of the dried immature fruit of citron orange, 11 parts of Chinese violet, 9 parts of rhizoma woodwardiae, 13 parts of litchi rind, 9 parts of sealwort, 12 parts of lycopodium calvatum, 8 parts of tribulus terrestris,
6 parts of 11 parts of fennel seeds and Rhizoma Arthromeritis mairei.The feed addictive for being used to prevent and treat sucking pig roundworm disease is liquid；It is described to be used to prevent and treat breast
Addition of the feed addictive of ascaris suum disease in the pig drinking water is 130 g kgs.
It is used for the feed addictive preparation method for preventing and treating sucking pig roundworm disease described in the present embodiment, methods described includes following step
Suddenly：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 3 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 4 times of weight waters respectively, soak 0.8 hour, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 55 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 4 times of weight percent methanols and 3 times of weight waters, under 45 degrees Celsius, backflow
Extract 6 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 3 times, finally mix each filtrate；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
Embodiment 4
Being used to prevent and treat the feed addictive of sucking pig roundworm disease described in the present embodiment includes the component of following parts by weight：7 parts of lotus leaf,
8 parts of the dried immature fruit of citron orange, 7 parts of Chinese violet, 11 parts of rhizoma woodwardiae, 8 parts of litchi rind, 11 parts of sealwort, 9 parts of lycopodium calvatum, 11 parts of tribulus terrestris, fennel fruit
Fragrant 10 parts and 8 parts of Rhizoma Arthromeritis mairei.The feed addictive for being used to prevent and treat sucking pig roundworm disease is liquid；It is described to be used to prevent and treat sucking pig ascarid
Addition of the feed addictive of parasitosis in the pig drinking water is 120 g kgs.
It is used for the feed addictive preparation method for preventing and treating sucking pig roundworm disease described in the present embodiment, methods described includes following step
Suddenly：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 3 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 3 times of weight waters respectively, soak 0.6 hour, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 58 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 5 times of weight percent methanols and 3 times of weight waters, under 48 degrees Celsius, backflow
Extract 5 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 3 times, finally mix each filtrate；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
Embodiment 5
Being used to prevent and treat the feed addictive of sucking pig roundworm disease described in the present embodiment includes the component of following parts by weight：8 parts of lotus leaf,
7 parts of the dried immature fruit of citron orange, 9 parts of Chinese violet, 10 parts of rhizoma woodwardiae, 9 parts of litchi rind, 10 parts of sealwort, 10 parts of lycopodium calvatum, 9 parts of tribulus terrestris, fennel fruit
Fragrant 10 parts and 7 parts of Rhizoma Arthromeritis mairei.The feed addictive for being used to prevent and treat sucking pig roundworm disease is liquid；It is described to be used to prevent and treat sucking pig ascarid
Addition of the feed addictive of parasitosis in the pig drinking water is 110 g kgs.
It is used for the feed addictive preparation method for preventing and treating sucking pig roundworm disease described in the present embodiment, methods described includes following step
Suddenly：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 4 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 3 times of weight waters respectively, soak 0.9 hour, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 53 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 6 times of weight percent methanols and 2 times of weight waters, under 44 degrees Celsius, backflow
Extract 5 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 2 times, finally mix each filtrate；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
Experimental example
1st, experimental subjects
Experiment pig is the domestic pig family natural infection ascaris suum of Chuzhou one disease 33,27~39kg of body weight.
2nd, experiment process
By 33 its random point 6 groups of natural infection ascaris suum disease, be divided into control group, 1 group, 2 groups, 3 groups, 4 groups and 5 groups, often
Group pig's head number is respectively 5,5,5,6,6 and 6, and experimental period is 25 days；Control group adds third in its drinking water
Sulphur imidazoles, addition of the zental in the pig drinking water is 100 g kgs, 1 group, 2 groups, 3 groups, 4 groups and 5 components
The feed addictive for being used to prevent and treat sucking pig roundworm disease that Jia Ru be described in embodiment 1,2,3,4,5.
3rd, experiment management
Each group feeding and management condition all same during experiment, observes the clinical symptoms of each group pig, feeding, drinking-water, spirit, excrement etc.
Situation.
4th, criterion
Prevention effect criterion is：Spirit, diet, defecation recover normal, and symptom, which is wholly absent, to be judged to cure；Spirit, diet,
Defecation take a favorable turn, and symptom substantially mitigates, and is judged to effectively；Symptom is even dead without taking a turn for the better, cut open inspection, and it is invalid to be judged to, and the results are shown in Table 1.
The ascaris suum preparation of table 1 is to ascaris suum prevention effect situation list
| Title | Spirit | Diet | Defecation | Cure rate（%） |
| 1 group | Swinery is energetic | Normally | Normally | 93.1 |
| 2 groups | Swinery is energetic | Normally | Normally | 94.1 |
| 3 groups | Swinery is energetic | Normally | Normally | 93.4 |
| 4 groups | Swinery is energetic | Normally | Normally | 93.9 |
| 5 groups | Swinery is energetic | Normally | Normally | 92.9 |
| Control group | 1 pig is listless | Normally | 1 pork chop excrement is abnormal | 90.6 |
As can be seen from Table 1, the present invention is used for the feed addictive for preventing and treating sucking pig roundworm disease with preferably preventing and treating ascaris suum effect
Really.Meanwhile, the feed addictive for preventing and treating sucking pig roundworm disease is used for as described in experimental result can draw embodiment 4, to preventing and treating pig
The improvement of roundworm and production performance is more excellent.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring the substantive content of the present invention.
Claims (6)
1. a kind of feed addictive for being used to prevent and treat sucking pig roundworm disease, it is characterised in that：It is described to be used to prevent and treat sucking pig roundworm disease
Feed addictive includes the component of following parts by weight：6~12 parts of lotus leaf, 3~9 parts of the dried immature fruit of citron orange, 5~13 parts of Chinese violet, rhizoma cibotii
7~12 parts of rhizome of cyrtomium, 7~14 parts of litchi rind, 8~12 parts of sealwort, 8~13 parts of lycopodium calvatum, 7~13 parts of tribulus terrestris, fennel seeds 9~12
5~9 parts of part and Rhizoma Arthromeritis mairei.
2. the feed addictive according to claim 1 for being used to prevent and treat sucking pig roundworm disease, it is characterised in that：It is described to be used to prevent
Controlling the feed addictive of sucking pig roundworm disease includes the component of following parts by weight：It is 7~11 parts of lotus leaf, 6~8 parts of the dried immature fruit of citron orange, pale reddish brown
7~11 parts of fourth, 9~11 parts of rhizoma woodwardiae, 8~13 parts of litchi rind, 9~11 parts of sealwort, 9~12 parts of lycopodium calvatum, tribulus terrestris 8~11
6~8 parts of part, 10~11 parts of fennel seeds and Rhizoma Arthromeritis mairei.
3. the feed addictive according to claim 1 for being used to prevent and treat sucking pig roundworm disease, it is characterised in that：It is described to be used to prevent
Controlling the feed addictive of sucking pig roundworm disease includes the component of following parts by weight：8 parts of lotus leaf, 7 parts of the dried immature fruit of citron orange, 9 parts of Chinese violet, dog
7 parts of 10 parts of ridge rhizome of cyrtomium, 9 parts of litchi rind, 10 parts of sealwort, 10 parts of lycopodium calvatum, 9 parts of tribulus terrestris, 10 parts of fennel seeds and Rhizoma Arthromeritis mairei.
4. the feed addictive according to claim 1 for being used to prevent and treat sucking pig roundworm disease, it is characterised in that：It is described to be used to prevent
The feed addictive for controlling sucking pig roundworm disease is liquid.
5. the feed addictive according to claim 1 for being used to prevent and treat sucking pig roundworm disease, it is characterised in that：It is described to be used to prevent
Addition of the feed addictive of sucking pig roundworm disease in the pig drinking water is controlled for 90~130 g kgs.
6. the preparation method such as according to any one of claims 1 to 5 for being used to prevent and treat the feed addictive of sucking pig roundworm disease, its
It is characterised by, methods described comprises the following steps：
（1）By the lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum, tribulus terrestris, fennel seeds and section
Limb fern is cleaned 2~4 times with clear water respectively；
（2）By the step（1）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle cleaning,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei add 3~5 times of weight waters respectively, soak 0.5~1.0 hour, pull drying out；
（3）By the step（2）Lotus leaf, the dried immature fruit of citron orange, Chinese violet, rhizoma woodwardiae, litchi rind, sealwort, lycopodium calvatum after middle drying,
Tribulus terrestris, fennel seeds and Rhizoma Arthromeritis mairei are crushed respectively, cross 50~60 mesh sieves, mixing；
（4）To the step（3）In mixed-powder add 3~6 times of weight percent methanols and 2~3 times of weight waters, it is Celsius 40~50
Under degree, refluxing extraction 5~7 hours, filtering retains filtrate, filter residue is repeated into aforesaid operations 2~3 times, finally by each filtrate
Mixing；
（5）Will be described rapid（4）In the evaporation of mixing filtrate decompression, be evaporated completely to the ethyl acetate, that is, the expelling parasite pig be made
Feed addictive.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107484908A (en) * | 2017-09-29 | 2017-12-19 | 界首市东永牧业有限公司 | A kind of preparation method for preventing and treating ascaris suum additive |
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| CN104026361A (en) * | 2014-05-10 | 2014-09-10 | 凤台县古店乡李杰养殖场 | Health-care pig feed for expelling parasites and preparation method thereof |
| CN104161177A (en) * | 2013-07-15 | 2014-11-26 | 河南联合英伟饲料有限公司 | Traditional Chinese medicine feed additive capable of promoting growth and improving meat quality of pigs |
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| CN104161177A (en) * | 2013-07-15 | 2014-11-26 | 河南联合英伟饲料有限公司 | Traditional Chinese medicine feed additive capable of promoting growth and improving meat quality of pigs |
| CN104026361A (en) * | 2014-05-10 | 2014-09-10 | 凤台县古店乡李杰养殖场 | Health-care pig feed for expelling parasites and preparation method thereof |
| CN105076700A (en) * | 2015-08-20 | 2015-11-25 | 马鞍山市金农牧业有限公司 | Special in-vivo parasiticide for black piglets |
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| CN107484908A (en) * | 2017-09-29 | 2017-12-19 | 界首市东永牧业有限公司 | A kind of preparation method for preventing and treating ascaris suum additive |
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