CN106943619A - A kind of liquid wound-dressing and preparation method thereof - Google Patents
A kind of liquid wound-dressing and preparation method thereof Download PDFInfo
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- CN106943619A CN106943619A CN201710160454.9A CN201710160454A CN106943619A CN 106943619 A CN106943619 A CN 106943619A CN 201710160454 A CN201710160454 A CN 201710160454A CN 106943619 A CN106943619 A CN 106943619A
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- dressing
- polyethylene glycol
- wound
- glycerine
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
It is more particularly to a kind of that there is liquid dressing of promotion wound healing and bacteria resistance function and preparation method thereof the present invention relates to a kind of liquid wound-dressing and preparation method thereof, belong to medical domain.Technical scheme is：Component constitutes mass percent：Polyethylene glycol 60% 97%, glycerine 1 25%, marine algae extract 1 10%, Aloe Vera Gel 1 10%.Auxiliary Liquid Material low cost prepared by the present invention, has no toxic side effect.Main composition is divided into the marine algae extract containing fucoidin, can voluntarily extract, can also in the market purchase, other compositions such as Aloe Vera Gel, glycerine, polyethylene glycol, its cheap market price, low cost.It is natural extract because the constituent of wanting of the present invention is fucoidin extract, and other composition Aloe Vera Gels, glycerine, polyethylene glycol are not medicines, and composition usage amount, within national dosage standard, the present invention has no toxic side effect.
Description
Technical field
The present invention relates to a kind of liquid wound-dressing and preparation method thereof, more particularly to it is a kind of have promote wound healing and
Liquid dressing of bacteria resistance function and preparation method thereof, belongs to medical domain.
Background technology
Skin is the outmost Rotating fields of human body, is first of barrier for stopping external environment and vivo environment, therefore
Protective effect during topmost function.But skin is that most direct organ is contacted with external environment again, therefore it is also to be easiest to
Because being influenceed and traumatogenic organ by various factors.So, effective nursing to skin trauma turns into field of medicaments
The important content of research, the skin that wound dressing is widely used can heal and repair as soon as possible when producing wound.It is existing
The wound dressing of technology promotes the effect of wound healing undesirable, high cost, and what is had also has toxic and side effect.
The content of the invention
It is an object of the invention to provide a kind of liquid wound-dressing and preparation method thereof, with promoting wound healing and antibacterial
Dual-use function, low cost has no toxic side effect, safe and practical, solve background technology exist above mentioned problem.
The technical scheme is that：
A kind of liquid wound-dressing, component constitutes mass percent and is：Polyethylene glycol 60%-97%, glycerine 1-25%, marine alga carry
Take thing 1-10%, Aloe Vera Gel 1-10%.
A kind of preparation method of liquid wound-dressing, is comprised the following steps：
1. each component is chosen by mass percentage standby, polyethylene glycol 60%-97%, glycerine 1-25%, fucoidin 1-10%, reed
Luxuriant growth glue 1-10%；
2. by marine algae extract powder, 80--120 mesh sieves is crossed, water is dissolved in, takes supernatant, it is standby；
3. polyethylene glycol, glycerine and Aloe Vera Gel are added in supernatant, blending stirs；
4. sterilize, bottle, as product.
The present invention is in use, be directly applied to wound.The only external application of this liquid dressing, forbids to take orally.
The polyethylene glycol, from the polyethylene glycol that molecular weight is 400；The purity of fucoidin in the marine algae extract
Should be more than 20%.
The marine algae extract, comprising based on Thallus Laminariae (Thallus Eckloniae) extract, spirulina extract, seaweed extract, tongue bar extract,
Undaria pinnitafida extract, Extraction of Eucheuma gelatinae and agar extract, are known commercially available prod.
Auxiliary Liquid Material low cost prepared by the present invention, has no toxic side effect.Main composition is divided into the marine alga containing fucoidin and carried
Take thing, can voluntarily extract, can also in the market purchase, other compositions such as Aloe Vera Gel, glycerine, polyethylene glycol, the market price is low
It is honest and clean, low cost.Constituent want for fucoidin extract due to the present invention, is natural extract, and other composition aloes
Glue, glycerine, polyethylene glycol are not medicines, and composition usage amount is within national dosage standard, nontoxic pair of the invention
Effect.
The invention has the advantages that and effect：Liquid dressing prepared by the present invention, which has, promotes wound healing and antibacterial
Dual-use function；Low cost, has no toxic side effect, safe and practical.
Embodiment
With reference to embodiment, the present invention is described further：
A kind of liquid wound-dressing, component constitutes mass percent and is：Polyethylene glycol 60%-97%, glycerine 1-25%, marine alga carry
Take thing 1-10%, Aloe Vera Gel 1-10%.
A kind of preparation method of liquid wound-dressing, is comprised the following steps：
1. by mass percentage choose each component it is standby, polyethylene glycol 60%-97%, glycerine 1-25%, marine algae extract 1-10%,
Aloe Vera Gel 1-10%；
3. by marine algae extract powder, 80--120 mesh sieves is crossed, water is dissolved in, takes supernatant, it is standby；
3. polyethylene glycol, glycerine and Aloe Vera Gel are added in supernatant, blending stirs；
4. sterilize, bottle, as product.
The present invention is in use, be directly applied to wound.The only external application of this liquid dressing, forbids to take orally.
The polyethylene glycol, from the polyethylene glycol that molecular weight is 400；
The purity of fucoidin should be more than 80% in the marine algae extract.
Six embodiment percentage composition part following tables of the present invention：
Table 1：The specific percentage composition of embodiment
With the specific percentage composition of table 1, according to the preparation method of foregoing fluid present invention dressing, 6 sections of liquid dressings are prepared,
For animal and clinical test etc..
Report on Animal on the present invention
Safety evaluatio is carried out to embodiment liquid dressing
20 BALB/c mouses, male and female half and half, the scholar 2g of body weight 20.With shaver by mouse web portion shaving,
Expose clean skin, make skin area about 3*3cm.Liquid dressing made from Example 1 is directly applied to mouse skin
Surface, every mouse is smeared once daily, and Continuous Observation evaluates its security.As a result find, with not smearing liquid dressing just
Normal mouse skin compares, and smears the mouse skin after liquid dressing without any adverse reaction, and surface becomes smooth exquisiteness.
Promote embodiment liquid dressing the zoopery effect assessment of wound healing
Bibliography《The progress of wound healing animal model》Method described in [Gao Fulei etc.], with
BALB/c mouse is experimental animal, sets up incision of skin wound model.Mouse part skin is cut with blade, is formed
Linear cuts, can be deep to subcutaneous, the long 2cm of wound.（Typically with scissors or blade cutting animal skin, linear cuts are formed, can
It is deep to subcutaneously, otch is often selected in back or the belly of animal.This model can be used for observation wound healing process and various complete
The influence to wound healing such as body or local medicine, the dressing used.）With " more health " biological fluid dressing（Nanchang Hua Kang
Medical science and technology Co., Ltd）For positive control, using 0.9% physiological saline as negative control, applied with the liquid prepared by embodiment 2
Expect for experimental group, effect of the test fluid present invention dressing to wound healing.Every group of experiment mice 20, dosage is each
1g, is uniformly applied to wound to whole wound is completely covered, changes once daily, continuous use 2 weeks.Experimental result is：Experiment
Component film time 4-7min, positive control film formation time 5-8min；With wound without infection, without redness, without incrustation, wound growth is good
Well as qualitative evaluation Wound healing index, continuous use is after 2 weeks, and all groups are without dead mouse, and physiological saline feminine gender is right
It is 25% according to group wound healing rate, positive controls wound healing rate is 80%, experimental group wound healing rate is 95%.Zoopery
Prove that there is good promotion wound healing according to liquid dressing prepared by embodiment 2.
Bibliography《The progress of wound healing animal model》Method described in [Gao Fulei etc.], with
BALB/c mouse is experimental animal, sets up incision of skin wound model.Mouse web portion skin is cut with blade
Skin, forms linear cuts, can be deep to subcutaneous, the long 2cm of wound.With " more health " biological fluid dressing（Nanchang Hua Kang medical treatment section
Skill Co., Ltd）For positive control, using 0.9% physiological saline as negative control, using liquid dressing made from embodiment 3 as experiment
Group, effect of the test fluid present invention dressing to wound healing.Every group of experiment mice 20, dosage is each 1g, uniform to apply
Smear in wound to whole wound is completely covered, change once daily, continuous use 2 weeks.Experimental result is：Experimental group film formation time
4-7min, positive control film formation time 5-8min；With wound without infection, without redness, without incrustation, wound well-grown is as qualitative
Wound healing index is evaluated, continuous use is after 2 weeks, and all groups are without dead mouse, and physiological saline negative control group wound is cured
Conjunction rate is 20%, and positive controls wound healing rate is 75%, and experimental group wound healing rate is 90%.Zoopery proves embodiment 3
Obtained liquid dressing has effects that good promotion wound healing.
Fungistatic effect evaluation to embodiment liquid dressing
1st, experiment material
1. liquid dressing made from embodiment 4
2. culture medium：Using broth bouillon
3. the preparation of strains tested suspension
6 kinds of pathogenic bacteria are inoculated in solid broth bouillon respectively, in 37 DEG C, incubated 24 h.With
Inoculation hook picking has carried out the fungus block of the media surface of strain inclined plane activation, adds sterile saline, is ground in tissue
Grind uniform in grinder, and the concentration of bacteria suspension is adjusted to 5 × 106 cfu/mL。
2nd, experimental method
By diameter 6mm filter paper dick, dried after being handled through autoclaving, respectively take 15 filter paper dicks to be made respectively in embodiment 5
1h is soaked in the liquid dressing and physiological saline that obtain.The bacteria suspension for drawing 0.2ml with liquid-transfering gun is uniformly applied in media surface
Smear, the filter paper soaked is then placed on media surface relevant position, each culture dish is equidistant to put 5 filter papers, lid
Good culture dish, 24 h are cultivated in 37 DEG C.The diameter of inhibition zone is determined, and is compared, each 3 culture dishes of strain.Experiment knot
Really（It is shown in Table 2）Show：Liquid dressing made from embodiment 4 has good fungistatic effect.
Table 2
| Bacterial strain | Antibacterial circle diameter mm |
| Staphylococcus aureus | 10.42±2.13 |
| Escherichia coli | 12.31±2.13 |
| Pneumococcus | 14.23±2.46 |
| Bacillus cereus | 13.67±1.37 |
| Candida albicans | 15.07±2.98 |
| Pseudomonas aeruginosa | 12.68±1.69 |
Embodiment liquid dressing trial effect is evaluated
1st, liquid dressing made from Example 5 and embodiment 6, tries out the people of number 60.Trial employment period does not find any bad shadow
Ring, its Wound healing is obtained for different degrees of improvement after user is on probation, wherein there are 20 people to be served using its rear wound
Effect is quickly repaired, obvious scar is not left yet.
The following is several model cases
（1）It is military so-and-so, female, 25 years old, in experimentation is done, left index finger was scratched by blade, and wound is first rinsed with running water,
But still haemophilia, liquid dressing made from external application embodiment 5 immediately, bleeding stops immediately, wound healing after 1 day, nothing
Infection.
（2）Zhao so-and-so, man 27 years old, is slided because of rainy day cycling road and fallen down, the scratch of left leg many places is rinsed with running water
Afterwards, liquid dressing made from external application embodiment 6, abrasion does not infect after 3 days, and wound heals substantially, is cured completely after 7 days
Close and do not occur scar.
（3）Huang, female, 45 years old, when being cut the dish with kitchen knife, by left hand middle finger cut wound, after being irrigated with running water still
After haemophilia, liquid dressing made from external application embodiment 5, stopped bleeding after 5min, wound heals substantially after 2 days, wound
Do not infect.
Claims (3)
1. a kind of liquid wound-dressing, it is characterised in that：Component constitutes mass percent：Polyethylene glycol 60%-97%, glycerine
1-25%, marine algae extract 1-10%, Aloe Vera Gel 1-10%.
2. a kind of liquid wound-dressing according to claim 1, it is characterised in that：The polyethylene glycol, from molecular weight
For 400 polyethylene glycol；Fucoidin purity in the marine algae extract should be more than 20%.
3. a kind of preparation method of liquid wound-dressing, it is characterised in that comprise the following steps：
1. by mass percentage choose each component it is standby, polyethylene glycol 60%-97%, glycerine 1-25%, marine algae extract 1-10%,
Aloe Vera Gel 1-10%；
2. by marine algae extract powder, 80--120 mesh sieves is crossed, water is dissolved in, takes supernatant, it is standby；
3. polyethylene glycol, glycerine and Aloe Vera Gel are added in supernatant, blending stirs；
4. sterilize, bottle, as product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710160454.9A CN106943619A (en) | 2017-03-17 | 2017-03-17 | A kind of liquid wound-dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710160454.9A CN106943619A (en) | 2017-03-17 | 2017-03-17 | A kind of liquid wound-dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106943619A true CN106943619A (en) | 2017-07-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710160454.9A Pending CN106943619A (en) | 2017-03-17 | 2017-03-17 | A kind of liquid wound-dressing and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102665412A (en) * | 2009-09-23 | 2012-09-12 | 克能药物有限公司 | Compositions and methods for inducing or enhancing connective tissue repair |
| CN102665733A (en) * | 2009-07-27 | 2012-09-12 | Arc医疗设备股份有限公司 | Pharmaceutical compositions comprising modified fucans for use in the treatment of fibrous adhesions and other disorders |
| CN105251045A (en) * | 2015-10-20 | 2016-01-20 | 青岛明月生物医用材料有限公司 | Fucoidin-containing biomedical hydrogel and preparation method thereof |
| CN105497964A (en) * | 2015-12-17 | 2016-04-20 | 青岛明月生物医用材料有限公司 | Fucoidin-alginate sponge and preparation method thereof |
| CN105709273A (en) * | 2016-04-08 | 2016-06-29 | 杭州吉为医疗科技有限公司 | Medical liquid dressing containing polyethylene glycol |
-
2017
- 2017-03-17 CN CN201710160454.9A patent/CN106943619A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102665733A (en) * | 2009-07-27 | 2012-09-12 | Arc医疗设备股份有限公司 | Pharmaceutical compositions comprising modified fucans for use in the treatment of fibrous adhesions and other disorders |
| CN102665412A (en) * | 2009-09-23 | 2012-09-12 | 克能药物有限公司 | Compositions and methods for inducing or enhancing connective tissue repair |
| CN105251045A (en) * | 2015-10-20 | 2016-01-20 | 青岛明月生物医用材料有限公司 | Fucoidin-containing biomedical hydrogel and preparation method thereof |
| CN105497964A (en) * | 2015-12-17 | 2016-04-20 | 青岛明月生物医用材料有限公司 | Fucoidin-alginate sponge and preparation method thereof |
| CN105709273A (en) * | 2016-04-08 | 2016-06-29 | 杭州吉为医疗科技有限公司 | Medical liquid dressing containing polyethylene glycol |
Non-Patent Citations (3)
| Title |
|---|
| 冯彬彬等: "《中药药理及应用》", 30 November 2015 * |
| 刘颖等: "岩藻多糖的研究进展", 《食品与发酵工业》 * |
| 符波扎依采夫: "《海洋生物综合利用》", 31 March 1987 * |
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