CN106943398A - 使用4‑甲基吡唑治疗人类个体的基因型特异性方法 - Google Patents

使用4‑甲基吡唑治疗人类个体的基因型特异性方法 Download PDF

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Publication number
CN106943398A
CN106943398A CN201710098759.1A CN201710098759A CN106943398A CN 106943398 A CN106943398 A CN 106943398A CN 201710098759 A CN201710098759 A CN 201710098759A CN 106943398 A CN106943398 A CN 106943398A
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individual
adh2
aldh2
ethanol
methylpyrazole
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Chinese (zh)
Inventor
托马斯·E·戴利
伊丽莎白·C·斯奎尔斯
金-洪·皮欧妮·于
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Raptor Therapeutics Inc
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Raptor Therapeutics Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201710098759.1A 2009-06-10 2010-06-09 使用4‑甲基吡唑治疗人类个体的基因型特异性方法 Pending CN106943398A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18588409P 2009-06-10 2009-06-10
US61/185,884 2009-06-10
CN2010800352852A CN102458121A (zh) 2009-06-10 2010-06-09 使用4-甲基吡唑治疗人类个体的基因型特异性方法

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CN2010800352852A Division CN102458121A (zh) 2009-06-10 2010-06-09 使用4-甲基吡唑治疗人类个体的基因型特异性方法

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CN106943398A true CN106943398A (zh) 2017-07-14

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CN201710098759.1A Pending CN106943398A (zh) 2009-06-10 2010-06-09 使用4‑甲基吡唑治疗人类个体的基因型特异性方法
CN2010800352852A Pending CN102458121A (zh) 2009-06-10 2010-06-09 使用4-甲基吡唑治疗人类个体的基因型特异性方法

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US (4) US20120252857A1 (enExample)
EP (2) EP2440049B1 (enExample)
JP (2) JP5836270B2 (enExample)
KR (3) KR20140138318A (enExample)
CN (2) CN106943398A (enExample)
AU (1) AU2010258821B2 (enExample)
DK (1) DK2440049T3 (enExample)
ES (1) ES2656489T3 (enExample)
NO (1) NO2440049T3 (enExample)
PT (1) PT2440049T (enExample)
SG (1) SG176734A1 (enExample)
TW (1) TWI523653B (enExample)
WO (1) WO2010144518A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109381458A (zh) * 2018-12-16 2019-02-26 李志武 甲吡唑及其盐在制备抗癫痫药物中的用途

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8901484B2 (en) * 2012-04-27 2014-12-02 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
JP6421249B2 (ja) * 2015-10-26 2018-11-07 株式会社日立製作所 デバッグを支援する方法及び計算機システム
WO2019209123A1 (en) * 2018-04-27 2019-10-31 Remedius Biotech Limited Diagnosis, risk reduction and treatment of conditions associated with elevated aldehyde levels
JP2025541701A (ja) * 2022-12-01 2025-12-23 ピコエンテック シーオー.,エルティーディー. 振戦または運動障害を抑制するための新規なアルデヒドデヒドロゲナーゼを含有する食品および薬物組成物
CN120475912A (zh) * 2022-12-01 2025-08-12 匹克生物酶高科技有限公司 用于改善行为和运功功能的新型醛脱氢酶食品和药剂组合物
WO2024117698A1 (en) * 2022-12-01 2024-06-06 PICOENTECH Co., LTD. Food and pharmaceutical composition for detoxifying endogenous aldehydes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080021083A1 (en) * 2004-03-03 2008-01-24 Daley Thomas E 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106620A (en) 1980-12-22 1982-07-02 Takara Shuzo Co Ltd Ameliorant for alcoholic metabolism
GB0404481D0 (en) 2004-02-28 2004-03-31 Rhodia Cons Spec Ltd Soap control agent
WO2009058874A1 (en) * 2007-11-02 2009-05-07 Monte Woodow C Methods and materials for treating or preventing diseases/disorders mediated by alcohol dehydrogenase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080021083A1 (en) * 2004-03-03 2008-01-24 Daley Thomas E 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109381458A (zh) * 2018-12-16 2019-02-26 李志武 甲吡唑及其盐在制备抗癫痫药物中的用途
CN109381458B (zh) * 2018-12-16 2020-09-01 李志武 甲吡唑及其盐在制备抗癫痫药物中的用途

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JP5836270B2 (ja) 2015-12-24
US20180098964A1 (en) 2018-04-12
KR20160147709A (ko) 2016-12-23
DK2440049T3 (en) 2018-02-19
EP3311811A1 (en) 2018-04-25
JP2015155422A (ja) 2015-08-27
TWI523653B (zh) 2016-03-01
AU2010258821B2 (en) 2016-03-10
US20120322843A1 (en) 2012-12-20
ES2656489T3 (es) 2018-02-27
SG176734A1 (en) 2012-01-30
JP2012529526A (ja) 2012-11-22
CN102458121A (zh) 2012-05-16
KR20140138318A (ko) 2014-12-03
WO2010144518A1 (en) 2010-12-16
US20120252857A1 (en) 2012-10-04
NO2440049T3 (enExample) 2018-05-12
TW201110966A (en) 2011-04-01
EP2440049B1 (en) 2017-12-13
EP2440049A1 (en) 2012-04-18
PT2440049T (pt) 2018-03-05
US20170007578A1 (en) 2017-01-12
KR20120032523A (ko) 2012-04-05
EP2440049A4 (en) 2012-12-05
AU2010258821A1 (en) 2012-01-19

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Application publication date: 20170714