JPS57106620A - Ameliorant for alcoholic metabolism - Google Patents

Ameliorant for alcoholic metabolism

Info

Publication number
JPS57106620A
JPS57106620A JP18170380A JP18170380A JPS57106620A JP S57106620 A JPS57106620 A JP S57106620A JP 18170380 A JP18170380 A JP 18170380A JP 18170380 A JP18170380 A JP 18170380A JP S57106620 A JPS57106620 A JP S57106620A
Authority
JP
Japan
Prior art keywords
compound
alcoholic
ameliorant
metabolism
alkylpyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18170380A
Other languages
Japanese (ja)
Inventor
Fusao Kimizuka
Hisao Matsunaga
Akira Obayashi
Osamu Tanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takara Shuzo Co Ltd
Original Assignee
Takara Shuzo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Shuzo Co Ltd filed Critical Takara Shuzo Co Ltd
Priority to JP18170380A priority Critical patent/JPS57106620A/en
Publication of JPS57106620A publication Critical patent/JPS57106620A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: An ameliorant for alcoholic metabolism, containing a 4-alkylpyrazole as an active constituent, having a powerful inhibitory activity against hepatic alcoholic dehydrogenase and having high safety.
CONSTITUTION: An ameliorant for alcoholic metabolism containing a 4-alkylpyrazole of formulaI(R is 1W10C alkyl) as an active constituent. The compound of formulaIadministered 10W100min before the drinking permits even persons, irresistant to alcohol, and exhibiting the unpleasant symptoms, e.g. facial flushing, pulsus frequens or polycardia, by drinking a small amount of SAKE to drink SAKE in an amount of several times that of the usual one. The compound of formulaIhas a high inhibitory activity aganst hepatic alcoholic dehydrogenase and the preventing action on the internal accumulation of aldehyde in the body which is consiered as the cause of the drunken sickness. The dose there of is preferably 1.5W10mg/kg, and the compound of formulaIcan be synthesized from a compound of formula II as a starting material.
COPYRIGHT: (C)1982,JPO&Japio
JP18170380A 1980-12-22 1980-12-22 Ameliorant for alcoholic metabolism Pending JPS57106620A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18170380A JPS57106620A (en) 1980-12-22 1980-12-22 Ameliorant for alcoholic metabolism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18170380A JPS57106620A (en) 1980-12-22 1980-12-22 Ameliorant for alcoholic metabolism

Publications (1)

Publication Number Publication Date
JPS57106620A true JPS57106620A (en) 1982-07-02

Family

ID=16105373

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18170380A Pending JPS57106620A (en) 1980-12-22 1980-12-22 Ameliorant for alcoholic metabolism

Country Status (1)

Country Link
JP (1) JPS57106620A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010144518A1 (en) 2009-06-10 2010-12-16 Raptor Therapeutics Inc. Genotype specific methods for treating human subjects using 4- methylpyrazole
US20160243082A1 (en) * 2004-03-03 2016-08-25 Raptor Pharmaceuticals Inc. 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160243082A1 (en) * 2004-03-03 2016-08-25 Raptor Pharmaceuticals Inc. 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance
WO2010144518A1 (en) 2009-06-10 2010-12-16 Raptor Therapeutics Inc. Genotype specific methods for treating human subjects using 4- methylpyrazole
EP3311811A1 (en) 2009-06-10 2018-04-25 Horizon Orphan LLC Genotype specific methods for treating human subjects using 4- methylpyrazole

Similar Documents

Publication Publication Date Title
WO2002005642A3 (en) Synergistic biocidal compositions
JPS57106620A (en) Ameliorant for alcoholic metabolism
JPS5377001A (en) New material and its preparation
JPS56140905A (en) Termite-killing agent composition
JPS53101531A (en) Repellent composition against birds
JPS52120132A (en) Remedies for nephric diseases
JPS5334768A (en) Preparation of diterpene derivatives
JPS53127813A (en) Agent for increasing drug sensitivity of antibiotic-resistant bacteria
JPS5665825A (en) Remedy for peptic ulcer
JPS5742620A (en) Novel antiulcer agent
JPS56127066A (en) Drink containing fractionated substance of aloe arborescens mill. var. natalensis berg.
JPS5735510A (en) Preventive and remedy for dermatosis sicca
JPS52139724A (en) Fungicidal and bactericidal composition
JPS5290698A (en) Prevention of deterioration of alcoholic beverages
JPS5540644A (en) Agent against candidiasis
JPS57159711A (en) Low oxygen cell sensitizer for radiation
JPS56152418A (en) Hypoglycemic agent
JPS5517329A (en) Remedy for dementia and dotage
JPS5679619A (en) Solid embrocation
JPS5241208A (en) Complete extraction of pharmaceutically active substances contained in mycelium and spores of "shiitake"
JPS5594317A (en) Antifungal agent
JPS571792A (en) Desensitizing liquid for lithographic plate
JPS53118597A (en) Method for keeping soy or miso from getting moldy
JPS53147015A (en) Preparation of unsaturated alcohol
AKULOV SANITARY AND TOXICOLOGICAL STUDIES OF THE PERMISSIBLE CONCENTRATION OF PHOSBUTYL IN WATER BODIES