CN106924291A - For mineral drug or the processing method of shell Chinese medicine - Google Patents
For mineral drug or the processing method of shell Chinese medicine Download PDFInfo
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- CN106924291A CN106924291A CN201710193009.2A CN201710193009A CN106924291A CN 106924291 A CN106924291 A CN 106924291A CN 201710193009 A CN201710193009 A CN 201710193009A CN 106924291 A CN106924291 A CN 106924291A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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Abstract
The invention discloses a kind of for mineral drug or the processing method of shell Chinese medicine, including step：（1）Meal is obtained after being crushed for the processing method of mineral drug or shell Chinese medicine；（2）Meal is poured into ethanol water mixed solution and is soaked, filtering obtains the first filter residue；（3）The first filter residue microwave treatment is then added into ethyl acetate, ultrasonically treated, filtering obtains the second filter residue, dries, and obtains powder；（4）Powder is added to the water, suspension is stirred into, 0~5 DEG C is cooled in advance, it is then quick-frozen 12~24 hours in 70 DEG C, after 0.09~0.096MPa vacuum drying, obtain dried powder；（5）Dried powder is carried out into ultramicro grinding, fine powder is obtained；（6）Hydroxypropyl beta cyclodextrin is dissolved in 8~10 times of water of weight, step is then added while stirring（5）Gained fine powder, continues to stir 20~40 minutes, dries, and obtains final product.
Description
Technical field
The present invention relates to a kind of Chinese medicine processing method, and in particular to a kind of for mineral drug or the treatment side of shell Chinese medicine
Method.Belong to Chinese medicine processing technology field.
Background technology
The conventional use of Chinese medicine is boiled with decocting, but the herbal medicine efficacy after being boiled with decocting tend to rely on patient or its
The means of boiling medicine of family members, the difference of personal means of boiling medicine directly affects the treatment results of Chinese medicine, and the decoction of medicine is very exquisite, has
Be decocted first, have it is rear under, have the need for wrapped decoction, had with cloth the need for decoct in addition, some medicines need decoct one
More than hour, some medicines take the dish out of the pot first 10 minutes by putting the inside, it is necessary to the item for noting is many.And for long-term clothes
For the patient of medicine, it is required for boiling medicine daily, time-consuming, and convenience is poor.In addition, the effective elements of the medicine is molten in water in some
Extracting rate is not high, it is impossible to fully discharge active ingredient, causes medicinal material to waste, also some Chinese medicines active ingredient quilt when high temperature is decocted
Destruction, and then influence drug effect.
With the development of science and technology, in the market occurs in that a kind of single herbal concentrate-granule, easy to use, takes after mixing it with water.But
Existing single herbal concentrate-granule quality level is irregular to differ, and the validity for much exempting to decoct particle can not show a candle to the direct drug effect for decocting.It is special
It is not mineral drug（Cinnabar, realgar, calamine etc.）And shell Chinese medicine（Pearl etc.）Water is substantially insoluble in, is made and is exempted to decoct particle
The problem for still suffering from effectively taking after mixing it with water.
Make medicinal substances shortcake frangible, be easy to absorb and improve the basic demand that drug effect is Chinese medicine preparation, current ultramicro grinding exists
Application in Chinese medicine preparation is more and more extensive, medicine can be ground into most suitable granularity by ultramicro grinding, preferably plays medicine
Effect.But, the meticulous particle surface of gained can be easier absorption air and with electric charge after ultramicro grinding, influence absorption of human body,
Increase storage difficulty.In addition, the pretreatment that medicine is carried out before ultramicro grinding is particularly important, if impurity can not be removed effectively, surpass
It is mixed in Ultramicro-powder after Crushing of Ultrafine, it is easier to be absorbed by the body, and then is detrimental to health.
The content of the invention
The purpose of the present invention is to overcome above-mentioned the deficiencies in the prior art, there is provided one kind is directed to mineral drug or shell Chinese medicine
Processing method.
To achieve the above object, the present invention uses following technical proposals：
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after mineral drug or shell Chinese medicine are crushed；
（2）Meal is poured into 5~10 times of alcohol-water mixed solutions of weight and is soaked 12~24 hours, filtering obtains the first filter
Slag；
（3）By the first filter residue in 300~450W microwave treatments 3~5 minutes, 5~8 times of ethyl acetate of weight are then added into
In, ultrasonically treated 2~3 hours, filtering obtained the second filter residue, dries, and obtains powder；
（4）By in powder 2~3 times of water of weight of addition, suspension is stirred into, 0~5 DEG C is cooled in advance, then in -70 DEG C quick-frozen 12
~24 hours, after 0.09~0.096MPa be vacuum dried 3~4 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, fine powder is obtained；
（6）HP-β-CD is dissolved in 8~10 times of water of weight, step is then added while stirring（5）Gained is thin
Powder, continues to stir 20~40 minutes, dries, and obtains final product Ultramicro-powder.
Preferably, selected from any one in cinnabar or realgar, the shell Chinese medicine is selected from the shell of seaear, treasure to the mineral drug
Any one in pearl or oyster.
Preferably, ethanol and the mass ratio of water are 2~3 in alcohol-water mixed solution：1.
Preferably, step（3）In, ultrasonically treated frequency is 25~40kHz.
Preferably, step（3）In, drying means is spray drying, and treatment conditions are：EAT is 90~115 DEG C, is gone out
Air temperature is 55~80 DEG C, and temperature of charge is 55~80 DEG C, and atomizing pressure is 0.4~0.7MPa.
Preferably, step（5）In, ultramicro grinding is to be ground into the fine powder that particle diameter is 1~10 μm by micronizer.
Preferably, step（6）In, drying means is freeze-drying, and treatment conditions are：It is cooled to 0~5 DEG C in advance, then -70 DEG C
Quick-frozen 3~4 hours, after 0.09~0.096MPa be vacuum dried 3~4 hours.
Beneficial effects of the present invention：
The invention provides a kind of for mineral drug or the preparation method of the single herbal concentrate-granule of shell Chinese medicine, mineral drug or shell
The effective elements of the medicine is water insoluble in class, different types of composition such as including calcium carbonate, mercuric sulphide, zinc oxide.
The present invention is processed after traditional Chinese medicine powder is broken into meal first with alcohol-water mixed solution, is removed water-soluble miscellaneous
Matter, then carries out microwave treatment by the first filter residue so that the first filter residue homogenizes, then with ethyl acetate combine it is ultrasonically treated,
Ethyl acetate takes away oil-soluble impurities, and being then added to the water gained powder after drying carries out cryogenic temperature freezing drying combination ultra micro
Crush, the uniform fine powder of particle diameter distribution can be obtained, finally by fine powder in HP-β-CD, last gained is super
Micro mist has a preferable mobility, more preferably human compatibility, beneficial to absorption.
It is worth noting that, although ethyl acetate belong to the 3rd class solvent in pharmacy, residual solvent amount is typically required not
It is acceptable higher than 0.5%.But ethyl acetate is once introduced in pharmacy procedure as solvent, the washing for generally using
Means, even if washing is many times（Increase production cost）, it is also difficult to control Determination of Residual Ethyl Acetate to be less than setting.The present invention exists
Step（4）It is middle powder is added to the water carry out cryogenic temperature freezing drying, in drying process, water can take away the acetic acid second of residual
Ester, so as to substantially reduce the Determination of Residual Ethyl Acetate in system.
Specific embodiment
With reference to embodiment, the present invention will be further elaborated, it should explanation, the description below merely to
The present invention is explained, its content is not defined.
The present invention is illustrated by taking oyster as an example, but processing method of the invention is not limited only in oyster this one kind
Medicinal material.
Embodiment 1：
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 5 times of alcohol-water mixed solutions of weight and is soaked 12 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 300W microwave treatments 3 minutes, it is then added into 5 times of ethyl acetate of weight, 25kHz surpasses
Sonication 2 hours, filtering, obtains the second filter residue, is spray-dried, and obtains powder；
（4）By in powder 2 times of water of weight of addition, suspension is stirred into, 0 DEG C is cooled in advance, it is then quick-frozen 12 hours in -70 DEG C,
After 0.09MPa be vacuum dried 3 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 1 μm is obtained；
（6）HP-β-CD is dissolved in 8 times of water of weight, step is then added while stirring（5）Gained fine powder, after
Continuous stirring 20 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 2 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of spray drying are：EAT is 90 DEG C, and leaving air temp is 55 DEG C, temperature of charge
It it is 55 DEG C, atomizing pressure is 0.4MPa.
Step（6）In, the treatment conditions of freeze-drying are：Be cooled to 0 DEG C in advance, then -70 DEG C it is quick-frozen 3 hours, after
0.09MPa is vacuum dried 3 hours.
Embodiment 2：
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 10 times of alcohol-water mixed solutions of weight and is soaked 24 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 450W microwave treatments 5 minutes, it is then added into 8 times of ethyl acetate of weight, 40kHz surpasses
Sonication 3 hours, filtering, obtains the second filter residue, is spray-dried, and obtains powder；
（4）By in powder 3 times of water of weight of addition, suspension is stirred into, 5 DEG C are cooled in advance, it is then quick-frozen 24 hours in -70 DEG C,
After 0.096MPa be vacuum dried 4 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 10 μm is obtained；
（6）HP-β-CD is dissolved in 10 times of water of weight, step is then added while stirring（5）Gained fine powder, after
Continuous stirring 40 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 3 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of spray drying are：EAT is 115 DEG C, and leaving air temp is 80 DEG C, material temperature
It is 80 DEG C to spend, and atomizing pressure is 0.7MPa.
Step（6）In, the treatment conditions of freeze-drying are：Be cooled to 5 DEG C in advance, then -70 DEG C it is quick-frozen 4 hours, after
0.096MPa is vacuum dried 4 hours.
Embodiment 3：
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 5 times of alcohol-water mixed solutions of weight and is soaked 24 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 300W microwave treatments 5 minutes, it is then added into 5 times of ethyl acetate of weight, 40kHz surpasses
Sonication 2 hours, filtering, obtains the second filter residue, is spray-dried, and obtains powder；
（4）By in powder 3 times of water of weight of addition, suspension is stirred into, 0 DEG C is cooled in advance, it is then quick-frozen 24 hours in -70 DEG C,
After 0.09MPa be vacuum dried 4 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 1 μm is obtained；
（6）HP-β-CD is dissolved in 10 times of water of weight, step is then added while stirring（5）Gained fine powder, after
Continuous stirring 20 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 3 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of spray drying are：EAT is 90 DEG C, and leaving air temp is 80 DEG C, temperature of charge
It it is 55 DEG C, atomizing pressure is 0.7MPa.
Step（6）In, the treatment conditions of freeze-drying are：Be cooled to 0 DEG C in advance, then -70 DEG C it is quick-frozen 4 hours, after
0.09MPa is vacuum dried 4 hours.
Embodiment 4：
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 10 times of alcohol-water mixed solutions of weight and is soaked 12 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 450W microwave treatments 3 minutes, it is then added into 8 times of ethyl acetate of weight, 25kHz surpasses
Sonication 3 hours, filtering, obtains the second filter residue, is spray-dried, and obtains powder；
（4）By in powder 2 times of water of weight of addition, suspension is stirred into, 5 DEG C are cooled in advance, it is then quick-frozen 12 hours in -70 DEG C,
After 0.096MPa be vacuum dried 3 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 10 μm is obtained；
（6）HP-β-CD is dissolved in 8 times of water of weight, step is then added while stirring（5）Gained fine powder, after
Continuous stirring 40 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 2 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of spray drying are：EAT is 115 DEG C, and leaving air temp is 55 DEG C, material temperature
It is 80 DEG C to spend, and atomizing pressure is 0.4MPa.
Step（6）In, the treatment conditions of freeze-drying are：Be cooled to 5 DEG C in advance, then -70 DEG C it is quick-frozen 3 hours, after
0.096MPa is vacuum dried 3 hours.
Embodiment 5：
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 8 times of alcohol-water mixed solutions of weight and is soaked 18 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 300W microwave treatments 4 minutes, it is then added into 7 times of ethyl acetate of weight, 30kHz surpasses
Sonication 2.5 hours, filtering, obtains the second filter residue, is spray-dried, and obtains powder；
（4）During powder added into 2.5 times of water of weight, suspension is stirred into, 3 DEG C are cooled in advance, then in -70 DEG C quick-frozen 18 small
When, after 0.09MPa be vacuum dried 3.5 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 8 μm is obtained；
（6）HP-β-CD is dissolved in 9 times of water of weight, step is then added while stirring（5）Gained fine powder, after
Continuous stirring 30 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 2.5 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of spray drying are：EAT is 100 DEG C, and leaving air temp is 70 DEG C, material temperature
It is 70 DEG C to spend, and atomizing pressure is 0.6MPa.
Step（6）In, the treatment conditions of freeze-drying are：Be cooled to 2 DEG C in advance, then -70 DEG C it is quick-frozen 3.5 hours, after
0.096MPa is vacuum dried 3.5 hours.
Comparative example 1
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 8 times of alcohol-water mixed solutions of weight and is soaked 18 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 300W microwave treatments 4 minutes, it is then added into 7 times of ethyl acetate of weight, 30kHz surpasses
Sonication 2.5 hours, filtering, obtains the second filter residue, is spray-dried, and obtains powder；
（4）During powder added into 2.5 times of water of weight, suspension is stirred into, 3 DEG C are cooled in advance, then in -70 DEG C quick-frozen 18 small
When, after 0.09MPa be vacuum dried 3.5 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 8 μm is obtained.
Wherein, ethanol and the mass ratio of water are 2.5 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of spray drying are：EAT is 100 DEG C, and leaving air temp is 70 DEG C, material temperature
It is 70 DEG C to spend, and atomizing pressure is 0.6MPa.
Comparative example 2
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）During meal added into 2.5 times of water of weight, suspension is stirred into, 3 DEG C are cooled in advance, then in -70 DEG C quick-frozen 18 small
When, after 0.09MPa be vacuum dried 3.5 hours, obtain dried powder；
（3）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 8 μm is obtained；
（4）HP-β-CD is dissolved in 9 times of water of weight, step is then added while stirring（3）Gained fine powder, after
Continuous stirring 30 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 2.5 in alcohol-water mixed solution：1.
Step（4）In, the treatment conditions of freeze-drying are：Be cooled to 2 DEG C in advance, then -70 DEG C it is quick-frozen 3.5 hours, after
0.096MPa is vacuum dried 3.5 hours.
Comparative example 3
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is carried out into ultramicro grinding, the fine powder that particle diameter is 8 μm is obtained；
（3）HP-β-CD is dissolved in 9 times of water of weight, step is then added while stirring（2）Gained fine powder, after
Continuous stirring 30 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 2.5 in alcohol-water mixed solution：1.
Step（3）In, the treatment conditions of freeze-drying are：Be cooled to 2 DEG C in advance, then -70 DEG C it is quick-frozen 3.5 hours, after
0.096MPa is vacuum dried 3.5 hours.
Comparative example 4
For mineral drug or the processing method of shell Chinese medicine, including step：
（1）Meal is obtained after oyster is crushed；
（2）Meal is poured into 8 times of alcohol-water mixed solutions of weight and is soaked 18 hours, filtering obtains the first filter residue；
（3）By the first filter residue in 300W microwave treatments 4 minutes, it is then added into 7 times of ethyl acetate of weight, 30kHz surpasses
Sonication 2.5 hours, filtering, obtains the second filter residue；
（4）Second filter residue is washed with water 4 times, is spray-dried, obtain powder；
（5）Dried powder is carried out into ultramicro grinding, the fine powder that particle diameter is 8 μm is obtained；
（6）HP-β-CD is dissolved in 9 times of water of weight, step is then added while stirring（5）Gained fine powder, after
Continuous stirring 30 minutes, freeze-drying obtains final product Ultramicro-powder.
Wherein, ethanol and the mass ratio of water are 2.5 in alcohol-water mixed solution：1.
Step（4）In, the treatment conditions of spray drying are：EAT is 100 DEG C, and leaving air temp is 70 DEG C, material temperature
It is 70 DEG C to spend, and atomizing pressure is 0.6MPa.
Step（6）In, the treatment conditions of freeze-drying are：Be cooled to 2 DEG C in advance, then -70 DEG C it is quick-frozen 3.5 hours, after
0.096MPa is vacuum dried 3.5 hours.
Test example
1st, fluidity determining
Angle of repose measure is carried out to the Ultramicro-powder of embodiment 1~5 and comparative example 1~4 using Repose angle gauge, be the results are shown in Table
1。
The fluidity determining of table 1.
As can be seen from Table 1, the angle of repose of embodiment 1~5 and comparative example 2 and comparative example 4 is small, and mobility more preferably, and is contrasted
Example 1 does not use HP-β-CD to include, and directly affects mobility, illustrates that Ultramicro-powder has agglomeration.Comparative example 3 is not
Carry out super cool-drying directly to be crushed, the mobility of gained Ultramicro-powder is not good enough yet.
2nd, Determination of Residual Ethyl Acetate
The solvent residual amount of the Ultramicro-powder of embodiment 1~5 and comparative example 1~4 is detected using gas chromatography, 2 are the results are shown in Table.
The Determination of Residual Ethyl Acetate of table 2.
As can be seen from Table 2, comparative example 4 uses conventional wash, and Determination of Residual Ethyl Acetate is higher than setting 0.5%, significantly larger than originally
Invention.
Although above-mentioned be described to specific embodiment of the invention, not to the limit of the scope of the present invention
System, on the basis of technical scheme, it is each that those skilled in the art make by need not paying creative work
Plant modification or deform still within protection scope of the present invention.
Claims (7)
1. for mineral drug or the processing method of shell Chinese medicine, it is characterised in that including step：
（1）Meal is obtained after mineral drug or shell Chinese medicine are crushed；
（2）Meal is poured into 5~10 times of alcohol-water mixed solutions of weight and is soaked 12~24 hours, filtering obtains the first filter
Slag；
（3）By the first filter residue in 300~450W microwave treatments 3~5 minutes, 5~8 times of ethyl acetate of weight are then added into
In, ultrasonically treated 2~3 hours, filtering obtained the second filter residue, dries, and obtains powder；
（4）By in powder 2~3 times of water of weight of addition, suspension is stirred into, 0~5 DEG C is cooled in advance, then in -70 DEG C quick-frozen 12
~24 hours, after 0.09~0.096MPa be vacuum dried 3~4 hours, obtain dried powder；
（5）Dried powder is carried out into ultramicro grinding, fine powder is obtained；
（6）HP-β-CD is dissolved in 8~10 times of water of weight, step is then added while stirring（5）Gained is thin
Powder, continues to stir 20~40 minutes, dries, and obtains final product Ultramicro-powder.
2. it is according to claim 1 a kind of for mineral drug or the processing method of shell Chinese medicine, it is characterised in that described
, selected from any one in cinnabar or realgar, the shell Chinese medicine is selected from any one in the shell of seaear, pearl or oyster for mineral drug.
3. it is according to claim 1 a kind of for mineral drug or the processing method of shell Chinese medicine, it is characterised in that second
Ethanol and the mass ratio of water are 2~3 in alcohol-water mixed solution：1.
4. it is according to claim 1 a kind of for mineral drug or the processing method of shell Chinese medicine, it is characterised in that step
（3）In, ultrasonically treated frequency is 25~40kHz.
5. it is according to claim 1 a kind of for mineral drug or the processing method of shell Chinese medicine, it is characterised in that step
（3）In, drying means is spray drying, and treatment conditions are：EAT is 90~115 DEG C, and leaving air temp is 55~80 DEG C, thing
Material temperature degree is 55~80 DEG C, and atomizing pressure is 0.4~0.7MPa.
6. it is according to claim 1 a kind of for mineral drug or the processing method of shell Chinese medicine, it is characterised in that step
（5）In, ultramicro grinding is to be ground into the fine powder that particle diameter is 1~10 μm by micronizer.
7. it is according to claim 1 a kind of for mineral drug or the processing method of shell Chinese medicine, it is characterised in that step
（6）In, drying means is freeze-drying, and treatment conditions are：Be cooled to 0~5 DEG C in advance, then -70 DEG C it is quick-frozen 3~4 hours, after
0.09~0.096MPa is vacuum dried 3~4 hours.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110404659A (en) * | 2019-08-01 | 2019-11-05 | 安徽惠丰国药有限公司 | A kind of Chinese medicine processing disintegrating process |
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| CN101822697A (en) * | 2009-07-13 | 2010-09-08 | 湖南省中医药研究院 | Preparation method of traditional Chinese medicine ultrafine formula particles |
| CN102532083A (en) * | 2010-12-24 | 2012-07-04 | 苏州宝泽堂医药科技有限公司 | Preparation process for formononetin with high purity |
| TW201436818A (en) * | 2013-03-20 | 2014-10-01 | Zhongshan zhongzhi pharmaceutical group co ltd | Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form |
| CN104352415A (en) * | 2014-10-20 | 2015-02-18 | 上海今强实业有限公司 | Preparation method of traditional Chinese medicine derivative |
| KR101711018B1 (en) * | 2016-02-25 | 2017-02-28 | 란핑 리우 | Chinese medicine for treating children constipation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110404659A (en) * | 2019-08-01 | 2019-11-05 | 安徽惠丰国药有限公司 | A kind of Chinese medicine processing disintegrating process |
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