CN106924291B - Treatment method for mineral medicine or shell type traditional Chinese medicine - Google Patents
Treatment method for mineral medicine or shell type traditional Chinese medicine Download PDFInfo
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- CN106924291B CN106924291B CN201710193009.2A CN201710193009A CN106924291B CN 106924291 B CN106924291 B CN 106924291B CN 201710193009 A CN201710193009 A CN 201710193009A CN 106924291 B CN106924291 B CN 106924291B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/28—Mercury; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
Abstract
The invention discloses a treatment method for mineral drugs or shell traditional Chinese medicines, which comprises the following steps: (1) pulverizing mineral medicine or shell type Chinese medicine to obtain coarse powder; (2) pouring the coarse powder into an ethanol-water mixed solution for soaking, and filtering to obtain first filter residue; (3) performing microwave treatment on the first filter residue, adding the first filter residue into ethyl acetate, performing ultrasonic treatment, filtering to obtain a second filter residue, and drying to obtain powder; (4) adding the powder into water, stirring to form a suspension, precooling to 0-5 ℃, quickly freezing at-70 ℃ for 12-24 hours, and then drying in vacuum at 0.09-0.096 MPa to obtain dry powder; (5) micronizing the dried powder to obtain fine powder; (6) and (3) dissolving hydroxypropyl-beta-cyclodextrin in water with the weight of 8-10 times, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 20-40 minutes, and drying to obtain the hydroxypropyl-beta-cyclodextrin.
Description
Technical Field
The invention relates to a method for treating traditional Chinese medicines, in particular to a method for treating mineral medicines or shell traditional Chinese medicines. Belongs to the technical field of traditional Chinese medicine treatment.
Background
The traditional usage of the traditional Chinese medicine is water decoction, but the efficacy of the traditional Chinese medicine after water decoction usually depends on the decoction means of patients or family members thereof, the treatment result of the traditional Chinese medicine is directly influenced by the difference of individual decoction means, the decoction of the traditional Chinese medicine is very exquisite, some medicines need to be decocted first, some medicines need to be decocted later, some medicines need to be decocted by being wrapped in cloth, some medicines need to be decocted additionally, some medicines need to be decocted for more than one hour, and some medicines need to be placed in the pot before being taken out of the pot for 10 minutes, so that the matters needing to be noticed are very many. Moreover, for patients taking the medicine for a long time, the medicine needs to be decocted every day, which is long in time consumption and poor in convenience. In addition, the dissolution rate of active ingredients of some traditional Chinese medicines in water is not high, the active ingredients cannot be fully released, so that medicinal materials are wasted, and active ingredients of some traditional Chinese medicines are damaged when the traditional Chinese medicines are decocted at high temperature, so that the drug effect is influenced.
With the development of science and technology, a decoction-free granule appears on the market, is convenient to use and can be taken after being mixed with water. However, the existing decoction-free granules have different quality levels, and the effectiveness of many decoction-free granules is far inferior to the effect of direct decoction. In particular, mineral medicines (cinnabar, realgar, calamine and the like) and shell-type traditional Chinese medicines (pearl and the like) are basically insoluble in water, and the problem that the decoction-free granules prepared from the mineral medicines are still incapable of being taken with water effectively is still solved.
The basic requirements of traditional Chinese medicine processing are that the medicine substances are crisp and easy to absorb and the medicine effect is improved, the application of the superfine grinding in the traditional Chinese medicine processing is more and more extensive at present, and the medicine can be ground into the optimum granularity by the superfine grinding so as to better exert the medicine effect. However, the surfaces of the ultrafine particles obtained after the ultrafine grinding are easy to adsorb air and carry electric charges, so that the absorption of a human body is influenced, and the storage difficulty is increased. In addition, the pretreatment before the superfine grinding of the medicine is particularly important, and if the impurities cannot be effectively removed, the medicine is mixed in the superfine powder after the superfine grinding, so that the medicine is more easily absorbed by a human body and further harms the health of the human body.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a treatment method for mineral medicines or shell-type traditional Chinese medicines.
In order to achieve the purpose, the invention adopts the following technical scheme:
the treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing mineral medicine or shell type Chinese medicinal materials to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 5-10 times that of the coarse powder, soaking for 12-24 hours, and filtering to obtain first filter residue;
(3) performing microwave treatment on the first filter residue for 3-5 minutes at 300-450W, adding the first filter residue into ethyl acetate with the weight being 5-8 times that of the first filter residue, performing ultrasonic treatment for 2-3 hours, filtering to obtain second filter residue, and drying to obtain powder;
(4) adding the powder into water with the weight 2-3 times of that of the powder, stirring to form a suspension, pre-cooling to 0-5 ℃, quickly freezing at-70 ℃ for 12-24 hours, and then drying in vacuum at 0.09-0.096 MPa for 3-4 hours to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder;
(6) dissolving hydroxypropyl-beta-cyclodextrin in water of which the weight is 8-10 times that of the hydroxypropyl-beta-cyclodextrin, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 20-40 minutes, and drying to obtain the superfine powder.
Preferably, the mineral medicine is selected from any one of cinnabar or realgar, and the shell type traditional Chinese medicine is selected from any one of abalone shell, pearl or oyster.
Preferably, the mass ratio of ethanol to water in the ethanol-water mixed solution is 2-3: 1.
preferably, in the step (3), the frequency of the ultrasonic treatment is 25-40 kHz.
Preferably, in the step (3), the drying method is spray drying, and the treatment conditions are as follows: the air inlet temperature is 90-115 ℃, the air outlet temperature is 55-80 ℃, the material temperature is 55-80 ℃, and the atomization pressure is 0.4-0.7 MPa.
Preferably, in the step (5), the ultrafine grinding is performed by grinding into fine powder with a particle size of 1-10 μm by an ultrafine grinder.
Preferably, in the step (6), the drying method is freeze drying, and the processing conditions are as follows: precooling to 0-5 ℃, quickly freezing for 3-4 hours at-70 ℃, and then drying for 3-4 hours in vacuum at 0.09-0.096 MPa.
The invention has the beneficial effects that:
the invention provides a preparation method of decoction-free granules for mineral medicines or shell-type traditional Chinese medicines, wherein the active ingredients of the mineral medicines or the shell-type traditional Chinese medicines are insoluble in water and comprise different types of ingredients such as calcium carbonate, mercuric sulfide, zinc oxide and the like.
The method comprises the steps of crushing the traditional Chinese medicinal materials into coarse powder, treating the coarse powder by using an ethanol-water mixed solution to remove water-soluble impurities, then performing microwave treatment on the first filter residue to homogenize the first filter residue, then performing ultrasonic treatment by using ethyl acetate in combination, taking away the fat-soluble impurities by using the ethyl acetate, then adding the dried powder into water to perform ultralow-temperature freeze drying and superfine crushing in combination, thus obtaining fine powder with uniform particle size distribution, and finally including the fine powder in hydroxypropyl-beta-cyclodextrin, wherein the obtained superfine powder has better fluidity, better human body compatibility and favorable absorption.
It is noted that although ethyl acetate is a third class of solvent in pharmaceutical formulations, it is generally acceptable to require a residual solvent content of no more than 0.5%. However, once ethyl acetate is introduced as a solvent in the pharmaceutical process, the washing means generally adopted makes it difficult to control the residual amount of ethyl acetate to be less than a prescribed value even if the washing is carried out many times (which increases the production cost). In the step (4), the powder is added into water for ultralow temperature freeze drying, and in the drying process, the residual ethyl acetate is taken away by the water, so that the residual amount of the ethyl acetate in the system is greatly reduced.
Detailed Description
The present invention will be further illustrated by the following examples, which are intended to be merely illustrative and not limitative.
The present invention is described by taking oysters as an example, but the processing method of the present invention is not limited to only oysters, which is a traditional Chinese medicine.
Example 1:
the treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight 5 times that of the coarse powder, soaking for 12 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 300W microwave for 3 minutes, then adding the first filter residue into ethyl acetate with the weight 5 times that of the first filter residue, carrying out ultrasonic treatment for 2 hours at 25kHz, filtering to obtain a second filter residue, and carrying out spray drying to obtain powder;
(4) adding the powder into water 2 times the weight of the powder, stirring to obtain a suspension, precooling to 0 ℃, quickly freezing at-70 ℃ for 12 hours, and then drying in vacuum at 0.09MPa for 3 hours to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 1 μm;
(6) dissolving hydroxypropyl-beta-cyclodextrin in water of 8 times of the weight of the hydroxypropyl-beta-cyclodextrin, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 20 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2: 1.
in the step (3), the spray drying conditions are as follows: the air inlet temperature is 90 ℃, the air outlet temperature is 55 ℃, the material temperature is 55 ℃, and the atomization pressure is 0.4 MPa.
In the step (6), the freeze-drying treatment conditions are as follows: precooling to 0 ℃, quickly freezing for 3 hours at-70 ℃, and then drying for 3 hours in vacuum at 0.09 MPa.
Example 2:
the treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 10 times that of the coarse powder, soaking for 24 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 450W microwave for 5 minutes, then adding the first filter residue into ethyl acetate with the weight of 8 times, carrying out ultrasonic treatment for 3 hours at 40kHz, filtering to obtain a second filter residue, and carrying out spray drying to obtain powder;
(4) adding the powder into 3 times of water by weight, stirring to obtain a suspension, precooling to 5 ℃, quickly freezing for 24 hours at-70 ℃, and then drying for 4 hours under vacuum of 0.096MPa to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 10 μm;
(6) dissolving hydroxypropyl-beta-cyclodextrin in 10 times of water by weight, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 40 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 3: 1.
in the step (3), the spray drying conditions are as follows: the air inlet temperature is 115 ℃, the air outlet temperature is 80 ℃, the material temperature is 80 ℃, and the atomization pressure is 0.7 MPa.
In the step (6), the freeze-drying treatment conditions are as follows: precooling to 5 ℃, quickly freezing for 4 hours at-70 ℃, and then drying for 4 hours in vacuum at 0.096 MPa.
Example 3:
the treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight 5 times that of the coarse powder, soaking for 24 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 300W microwave for 5 minutes, then adding the first filter residue into ethyl acetate with the weight 5 times that of the first filter residue, carrying out ultrasonic treatment for 2 hours at 40kHz, filtering to obtain a second filter residue, and carrying out spray drying to obtain powder;
(4) adding the powder into 3 times of water by weight, stirring to obtain a suspension, precooling to 0 ℃, quickly freezing for 24 hours at-70 ℃, and then drying for 4 hours under vacuum at 0.09MPa to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 1 μm;
(6) dissolving hydroxypropyl-beta-cyclodextrin in 10 times of water by weight, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 20 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 3: 1.
in the step (3), the spray drying conditions are as follows: the air inlet temperature is 90 ℃, the air outlet temperature is 80 ℃, the material temperature is 55 ℃, and the atomization pressure is 0.7 MPa.
In the step (6), the freeze-drying treatment conditions are as follows: precooling to 0 ℃, quickly freezing for 4 hours at-70 ℃, and then drying for 4 hours in vacuum at 0.09 MPa.
Example 4:
the treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 10 times that of the coarse powder, soaking for 12 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 450W microwave for 3 minutes, then adding the first filter residue into ethyl acetate with the weight of 8 times, carrying out ultrasonic treatment for 3 hours at 25kHz, filtering to obtain a second filter residue, and carrying out spray drying to obtain powder;
(4) adding the powder into water 2 times the weight of the powder, stirring to obtain a suspension, precooling to 5 ℃, quickly freezing for 12 hours at-70 ℃, and then drying for 3 hours under vacuum at 0.096MPa to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 10 μm;
(6) dissolving hydroxypropyl-beta-cyclodextrin in water of 8 times of the weight of the hydroxypropyl-beta-cyclodextrin, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 40 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2: 1.
in the step (3), the spray drying conditions are as follows: the air inlet temperature is 115 ℃, the air outlet temperature is 55 ℃, the material temperature is 80 ℃, and the atomization pressure is 0.4 MPa.
In the step (6), the freeze-drying treatment conditions are as follows: precooling to 5 ℃, quickly freezing for 3 hours at-70 ℃, and then drying for 3 hours in vacuum at 0.096 MPa.
Example 5:
the treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 8 times that of the coarse powder, soaking for 18 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 300W microwave for 4 minutes, then adding the first filter residue into ethyl acetate with the weight being 7 times that of the first filter residue, carrying out ultrasonic treatment for 2.5 hours at 30kHz, filtering to obtain a second filter residue, and carrying out spray drying to obtain powder;
(4) adding the powder into water with the weight 2.5 times of that of the powder, stirring to form a suspension, precooling to 3 ℃, quickly freezing for 18 hours at the temperature of minus 70 ℃, and then drying for 3.5 hours in vacuum at the pressure of 0.09MPa to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 8 μm;
(6) dissolving hydroxypropyl-beta-cyclodextrin in 9 times of water by weight, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 30 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2.5: 1.
in the step (3), the spray drying conditions are as follows: the air inlet temperature is 100 ℃, the air outlet temperature is 70 ℃, the material temperature is 70 ℃, and the atomization pressure is 0.6 MPa.
In the step (6), the freeze-drying treatment conditions are as follows: precooling to 2 ℃, quickly freezing for 3.5 hours at-70 ℃, and then drying for 3.5 hours in vacuum at 0.096 MPa.
Comparative example 1
The treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 8 times that of the coarse powder, soaking for 18 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 300W microwave for 4 minutes, then adding the first filter residue into ethyl acetate with the weight being 7 times that of the first filter residue, carrying out ultrasonic treatment for 2.5 hours at 30kHz, filtering to obtain a second filter residue, and carrying out spray drying to obtain powder;
(4) adding the powder into water with the weight 2.5 times of that of the powder, stirring to form a suspension, precooling to 3 ℃, quickly freezing for 18 hours at the temperature of minus 70 ℃, and then drying for 3.5 hours in vacuum at the pressure of 0.09MPa to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 8 μm.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2.5: 1.
in the step (3), the spray drying conditions are as follows: the air inlet temperature is 100 ℃, the air outlet temperature is 70 ℃, the material temperature is 70 ℃, and the atomization pressure is 0.6 MPa.
Comparative example 2
The treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) adding the coarse powder into water 2.5 times the weight of the coarse powder, stirring to form a suspension, precooling to 3 ℃, quickly freezing for 18 hours at-70 ℃, and then drying for 3.5 hours in vacuum at 0.09MPa to obtain dry powder;
(3) micronizing the dried powder to obtain fine powder with particle size of 8 μm;
(4) dissolving hydroxypropyl-beta-cyclodextrin in 9 times of water by weight, adding the fine powder obtained in the step (3) while stirring, continuously stirring for 30 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2.5: 1.
in the step (4), the freeze-drying treatment conditions are as follows: precooling to 2 ℃, quickly freezing for 3.5 hours at-70 ℃, and then drying for 3.5 hours in vacuum at 0.096 MPa.
Comparative example 3
The treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) micronizing the coarse powder to obtain fine powder with particle size of 8 μm;
(3) dissolving hydroxypropyl-beta-cyclodextrin in 9 times of water by weight, adding the fine powder obtained in the step (2) while stirring, continuously stirring for 30 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2.5: 1.
in the step (3), the freeze-drying treatment conditions are as follows: precooling to 2 ℃, quickly freezing for 3.5 hours at-70 ℃, and then drying for 3.5 hours in vacuum at 0.096 MPa.
Comparative example 4
The treatment method aiming at mineral drugs or shell traditional Chinese medicines comprises the following steps:
(1) pulverizing Concha Ostreae to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 8 times that of the coarse powder, soaking for 18 hours, and filtering to obtain first filter residue;
(3) treating the first filter residue with 300W microwave for 4 minutes, then adding the first filter residue into ethyl acetate with the weight being 7 times that of the first filter residue, carrying out ultrasonic treatment for 2.5 hours at 30kHz, and filtering to obtain a second filter residue;
(4) washing the second filter residue with water for 4 times, and spray drying to obtain powder;
(5) micronizing the dried powder to obtain fine powder with particle size of 8 μm;
(6) dissolving hydroxypropyl-beta-cyclodextrin in 9 times of water by weight, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 30 minutes, and freeze-drying to obtain the superfine powder.
Wherein the mass ratio of ethanol to water in the ethanol-water mixed solution is 2.5: 1.
in the step (4), the spray drying conditions are as follows: the air inlet temperature is 100 ℃, the air outlet temperature is 70 ℃, the material temperature is 70 ℃, and the atomization pressure is 0.6 MPa.
In the step (6), the freeze-drying treatment conditions are as follows: precooling to 2 ℃, quickly freezing for 3.5 hours at-70 ℃, and then drying for 3.5 hours in vacuum at 0.096 MPa.
Test examples
1. Determination of flowability
The results of angle of repose measurements on the ultrafine powders of examples 1 to 5 and comparative examples 1 to 4 using an angle of repose measuring instrument are shown in Table 1.
TABLE 1 flowability measurement
As can be seen from Table 1, the angle of repose of examples 1-5 and comparative examples 2 and 4 is small, and the fluidity is better, while the fluidity is directly influenced by the comparative example 1 without using hydroxypropyl-beta-cyclodextrin for inclusion, which indicates that the ultrafine powder has agglomeration phenomenon. Comparative example 3 the ultrafine powder obtained by pulverizing the powder without ultracold drying was poor in flowability.
2. Residual quantity of ethyl acetate
The solvent residue of the ultrafine powders of examples 1 to 5 and comparative examples 1 to 4 was measured by gas chromatography, and the results are shown in Table 2.
TABLE 2 residual Ethyl acetate
As can be seen from Table 2, in comparative example 4, in which the conventional washing was employed, the residual amount of ethyl acetate was higher than the specified value of 0.5%, which is far higher than that of the present invention.
Although the present invention has been described with reference to the specific embodiments, it is not intended to limit the scope of the present invention, and various modifications and variations can be made by those skilled in the art without inventive changes based on the technical solution of the present invention.
Claims (2)
1. The treatment method for mineral drugs or shell traditional Chinese medicines is characterized by comprising the following steps:
(1) pulverizing mineral medicine or shell type Chinese medicine to obtain coarse powder;
(2) pouring the coarse powder into an ethanol-water mixed solution with the weight being 5-10 times that of the coarse powder, soaking for 12-24 hours, and filtering to obtain first filter residue;
(3) performing microwave treatment on the first filter residue for 3-5 minutes at 300-450W, adding the first filter residue into ethyl acetate with the weight being 5-8 times that of the first filter residue, performing ultrasonic treatment for 2-3 hours, filtering to obtain second filter residue, and drying to obtain powder;
(4) adding the powder into water with the weight 2-3 times of that of the powder, stirring to form a suspension, pre-cooling to 0-5 ℃, quickly freezing at-70 ℃ for 12-24 hours, and then drying in vacuum at 0.09-0.096 MPa for 3-4 hours to obtain dry powder;
(5) micronizing the dried powder to obtain fine powder;
(6) dissolving hydroxypropyl-beta-cyclodextrin in water with the weight of 8-10 times, adding the fine powder obtained in the step (5) while stirring, continuously stirring for 20-40 minutes, and drying to obtain superfine powder;
the mineral medicine is selected from one of cinnabar or realgar, and the shell type traditional Chinese medicine is selected from one of abalone shell, pearl or oyster; in the step (5), the superfine grinding is carried out by grinding into fine powder with the particle size of 1-10 mu m through a superfine grinder;
the mass ratio of ethanol to water in the ethanol-water mixed solution is 2-3: 1;
in the step (3), the frequency of ultrasonic treatment is 25-40 kHz;
in the step (3), the drying method is spray drying, and the treatment conditions are as follows: the air inlet temperature is 90-115 ℃, the air outlet temperature is 55-80 ℃, the material temperature is 55-80 ℃, and the atomization pressure is 0.4-0.7 MPa.
2. The method for treating mineral drugs or shell-type traditional Chinese medicines according to claim 1, wherein in the step (6), the drying method is freeze-drying, and the treatment conditions are as follows: precooling to 0-5 ℃, quickly freezing for 3-4 hours at-70 ℃, and then drying for 3-4 hours in vacuum at 0.09-0.096 MPa.
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| CN101822697A (en) * | 2009-07-13 | 2010-09-08 | 湖南省中医药研究院 | Preparation method of traditional Chinese medicine ultrafine formula particles |
| TW201436818A (en) * | 2013-03-20 | 2014-10-01 | Zhongshan zhongzhi pharmaceutical group co ltd | Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form |
| KR101711018B1 (en) * | 2016-02-25 | 2017-02-28 | 란핑 리우 | Chinese medicine for treating children constipation |
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| CN101474314A (en) * | 2009-02-02 | 2009-07-08 | 普洱市人民政府茶产业发展办公室科技服务中心 | Application of catechin in pharmacy |
| CN102532083A (en) * | 2010-12-24 | 2012-07-04 | 苏州宝泽堂医药科技有限公司 | Preparation process for formononetin with high purity |
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| CN101822697A (en) * | 2009-07-13 | 2010-09-08 | 湖南省中医药研究院 | Preparation method of traditional Chinese medicine ultrafine formula particles |
| TW201436818A (en) * | 2013-03-20 | 2014-10-01 | Zhongshan zhongzhi pharmaceutical group co ltd | Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form |
| KR101711018B1 (en) * | 2016-02-25 | 2017-02-28 | 란핑 리우 | Chinese medicine for treating children constipation |
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Effective date of registration: 20230823 Address after: Room 4014, No. 258 Fulin Road, Hengqin New District, Zhuhai City, Guangdong Province, 519031 Patentee after: Zhuhai Hengqin Maikairui Pharmaceutical Technology Co.,Ltd. Address before: 262300 Wulian People's Hospital of Shandong, Rizhao City Province, China Patentee before: Wang Quanli |