CN108785471A - A kind of arisaema cum bile prepared slices of Chinese crude drugs and preparation method thereof - Google Patents
A kind of arisaema cum bile prepared slices of Chinese crude drugs and preparation method thereof Download PDFInfo
- Publication number
- CN108785471A CN108785471A CN201810862053.2A CN201810862053A CN108785471A CN 108785471 A CN108785471 A CN 108785471A CN 201810862053 A CN201810862053 A CN 201810862053A CN 108785471 A CN108785471 A CN 108785471A
- Authority
- CN
- China
- Prior art keywords
- preparation
- arisaema cum
- cum bile
- crude drugs
- chinese crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000941 bile Anatomy 0.000 title claims abstract description 78
- 241000489492 Arisaema Species 0.000 title claims abstract description 55
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 229940079593 drug Drugs 0.000 title claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 51
- 239000002245 particle Substances 0.000 claims abstract description 46
- 239000003595 mist Substances 0.000 claims abstract description 15
- 238000012545 processing Methods 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 239000011812 mixed powder Substances 0.000 claims description 26
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims description 24
- 239000004380 Cholic acid Substances 0.000 claims description 24
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 24
- 229960002471 cholic acid Drugs 0.000 claims description 24
- 235000019416 cholic acid Nutrition 0.000 claims description 24
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 19
- 239000012153 distilled water Substances 0.000 claims description 17
- 241001494479 Pecora Species 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 31
- 231100000419 toxicity Toxicity 0.000 abstract description 10
- 230000001988 toxicity Effects 0.000 abstract description 10
- 230000007794 irritation Effects 0.000 abstract description 9
- 238000002156 mixing Methods 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000000855 fermentation Methods 0.000 abstract description 4
- 230000004151 fermentation Effects 0.000 abstract description 4
- 239000000047 product Substances 0.000 description 56
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 10
- 239000013078 crystal Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 241000283707 Capra Species 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 5
- 206010010904 Convulsion Diseases 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 230000036461 convulsion Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000011017 operating method Methods 0.000 description 4
- 241000332007 Arisaema erubescens Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 241000317412 Arisaema amurense Species 0.000 description 1
- 241000317400 Arisaema heterophyllum Species 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010021036 Hyponatraemia Diseases 0.000 description 1
- 241000322338 Loeseliastrum Species 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010044684 Trismus Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to the preparing technical fields of the prepared slices of Chinese crude drugs, and in particular to a kind of preparation method of the arisaema cum bile prepared slices of Chinese crude drugs includes the following steps:The preparation of Rhizoma Arisaematis (processed) micro mist is weighed and is mixed, the preparation of soft grit and the preparation of hard particles;Solves the problem that the fermentation method process-cycle is long, and mixing method product toxicity is big, and product is unstable and quality is uncontrollable;By the processing to Rhizoma Arisaematis (processed), the toxicity of medicinal powder is reduced, to reduce the irritation of arisaema cum bile Chinese medicine;By processing obtained courage powder, realizes fixed product formula ratio, achieve the purpose that quality controllable;With technological operation simplicity, product is easy to use, process-cycle short advantage;The present invention also provides a kind of tablet prepared by the preparation method or the arisaema cum bile prepared slices of Chinese crude drugs of particle, have the advantages that stability is good, easy to use.
Description
Technical field
The present invention relates to the preparing technical fields of the prepared slices of Chinese crude drugs, and in particular to a kind of arisaema cum bile prepared slices of Chinese crude drugs and its preparation side
Method.
Background technology
Rhizoma Arisaematis (processed), Chinese medicine name.For the Preparation process product of rhizoma arisaematis.Rhizoma arisaematis is distributed Hebei, Henan, Guangxi, Shaanxi, lake
The ground such as north, Sichuan, Guizhou, Yunnan, Shanxi.Arisaema heterophyllum Blume is distributed Heilungkiang, Jilin, Liaoning, Zhejiang, Jiangsu, intermal comflict west, lake
The ground such as north, Sichuan, Shaanxi.Arisaema amurense Maxim is distributed Heilungkiang, Jilin, Liaoning, Hebei, the ground such as Jiangxi, Hubei, Sichuan.Its south
Star has the effect of eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating;For stupid productive cough, anemophlegmatic vertigo, heap soil or fertilizer over and around the roots of apoplexy phlegm, mouth eye
Tiltedly, hemiplegia, epilepsy, infantile convulsion, lockjaw;Carbuncle swells, snakebite and bugbite are controlled in external application.Rhizoma arisaematis is listed in toxic traditional Chinese medicine, be because
Containing a kind of to mucous membrane of mouth ingredient excitatory " needle-like calcium oxalate crystal " in medicinal material, the irritation toxicity system plant of rhizoma arisaematis is thin
Caused by needle-like calcium oxalate crystal in born of the same parents, it is known as " malicious needle " by industry;The length of unprocessed Arisaema erubescens calcium oxalate crystal growth in healthy needle is 63-131um,
The length of Rhizoma Arisaematis (processed) calcium oxalate crystal growth in healthy needle is 6-35um.The experimental results showed that the smaller irritation of the length of needle-like calcium oxalate crystal is got over
Small, the toxicity of performance is lower.
Arisaema cum bile is fine powder and ox, sheep or the pig's bile of Rhizoma Arisaematis (processed) through being mixed and processed, or is unprocessed Arisaema erubescens fine powder
With ox, sheep or pig's bile are fermented is process;With clearing heat and eliminating phlegm, the function of dispelling wind and relieving convulsion.Not due to national standard technique
It is clear, without exact technological parameter, cause concocting method all parts of the country of arisaema cum bile very inconsistent, and the preparation process time
Different in size, main formula usage ratio differs, and various regions product standard is caused to differ;Different processing methods, different proportion
Raw material necessarily causes the difference of product quality, Clinical practice effect to be difficult to grasp.
Fermentation method, the process time is long, even several years several months that could complete the operation of a collection of product, since efficiency is low
Under, product quality can not ensure.
Mixing method, the production that can complete a collection of product in generally 5-7 days, makes working hour shorten dramatically, and is suitble to industrialized production,
Adopted at present by a part of enterprise.But from the point of view of the technique just used at present, however it remains following defect:Rhizoma Arisaematis (processed) medicinal powder is
60-80 mesh, powder is thicker, and needle-like calcium oxalate crystal is still larger, and product still has larger irritation(It is now recognized that needle-like calcium oxalate crystal
For toxic component), cause the toxic side effect of arisaema cum bile drug big, irritation is big.
Currently, either mixing method or fermentation method, are fed intake with bile, the source before feeding intake because of bile and storage side
Method, storage time length are different, and keep water evaporation quantity different, and the consistency of bile is made gap occur;Bile and Rhizoma Arisaematis (processed) powder
It needs to continue to refine after mixing that moisture is made to continue to evaporate, since mixture viscosity is larger, operation is extremely difficult, causes working hour still
It is longer.Therefore, using bile as feeding intake, the content of cholic acid has differences in the bile of same volume every time, causes bile and system
The each ingredient proportion of rhizoma arisaematis is different, increases operation difficulty, extends the process-cycle.In addition, prior art is due to courage south
Star finished product viscosity is big, needs to cut into irregular shape by hand, and appearance is coarse, and pharmacy is adjusted need to claim to weigh when using with weighing with a small steelyard,
Inconvenience is above caused to using, product is also unsightly.
Invention content
In view of the deficiencies of the prior art, the present invention intends to provide a kind of preparation side of the arisaema cum bile prepared slices of Chinese crude drugs
Method solves the problem that the fermentation method process-cycle is long, and mixing method product toxicity is big, and product is unstable and quality is uncontrollable;It is logical
The processing to Rhizoma Arisaematis (processed) is crossed, the toxicity of medicinal powder is reduced, to reduce the irritation of arisaema cum bile Chinese medicine;It is obtained by processing
Courage powder, realize fixed product formula ratio, achieve the purpose that quality controllable;With technological operation simplicity, product user
Just, process-cycle short advantage.
The purpose of the present invention is achieved through the following technical solutions:
A kind of preparation method of the arisaema cum bile prepared slices of Chinese crude drugs, includes the following steps:
(1)The preparation of Rhizoma Arisaematis (processed) micro mist:Rhizoma Arisaematis (processed) is crushed, 1200 mesh sieve is crossed, obtains Rhizoma Arisaematis (processed) micro mist;
(2)It weighs and mixes:5-10 parts of Rhizoma Arisaematis (processed) micro mist is weighed, 1-5 parts of animal gall powder is mixed and stirred for uniformly, being mixed
Close medicinal powder;
(3)The preparation of soft grit:Distilled water is added on mixed powder, and mixed powder is made to assemble to form soft grit;
(4)The preparation of arisaema cum bile particle:Soft grit is dehydrated, is granulated, it is dry, obtain arisaema cum bile particle.
By using above-mentioned technical proposal, Rhizoma Arisaematis (processed) is crushed to fineness and reaches 10um hereinafter, thus by unprocessed Arisaema erubescens
Needle-like calcium oxalate crystal(63-131um)And Rhizoma Arisaematis (processed) needle-like calcium oxalate crystal(6-35um)Filtering removal, greatly reduces Rhizoma Arisaematis (processed)
Irritation(Toxicity), thoroughly solve the problems, such as that other methods process product toxicity not in place, make calcium oxalate contained in product
Needle has been crushed, and will not generate irritation to mucous membrane of mouth again, the safety of product is protected.With ox, sheep or Pulvis Fellis Suis
Instead of ox, sheep or pig's bile, makes the proportioning fixation of courage powder and Rhizoma Arisaematis (processed) and controllable, improve the quality stability of product, ensure
The drug effect of product.Animal gall powder feeds intake, and soft grit is mixed into as adhesive using a small amount of water, is directly prepared into particle drying, one
Batch products can be completed in 8 hours, and life cycle of the product is made to be greatly shortened, and improve processing efficiency.Reduce soft
The water content of grain improves pellet hardness, is fabricated to the arisaema cum bile particle that water content is 7% or so, in transient process, realizes system
Rhizoma arisaematis micro mist is mixed with the depth of courage powder, coordinates the mixing process at initial stage, is kept product more uniform, be ensure that finished product
Quality stability, to ensure the drug effect of product.
Preferably, step(2)In, 6-8 parts of Rhizoma Arisaematis (processed) micro mist is weighed, 2-3 parts of animal gall powder is mixed and stirred for
It is even, obtain mixed powder.
By using above-mentioned technical proposal, the content of cholic acid in product is further increased, to which depth improves the medicine of product
Effect.
Preferably, step(3)In, spray distilled water with spray-on process;The additive amount of the distilled water is 1-3 parts.
By using above-mentioned technical proposal, distilled water is sprayed with spray-on process, accelerates the granulating speed of mixed powder, and
Ensure that the granulating degree of mixed powder is more uniform;Dilutional hyponatremia is distilled, then so that mixed powder is become fluid, it is difficult to be formed soft
Particle influences to operate to be difficult to be sieved;Distilled water is very few, then prevents mixed powder from all granulating, influence subsequent product
The effect of machine-shaping;In the distilled water content range of the present invention, the soft grit degree highest of mixed powder, effect is most
It is good.
Preferably, step(4)In, it after crossing 10-16 mesh screens to soft grit, is dehydrated, is granulated, it is dry, hard is made
Particle.
It is dehydrated with comminutor after carrying out preliminary screening to soft grit by using above-mentioned technical proposal, water content is made
Lower hard particles, drying to water content are 7% or so, obtain finished product arisaema cum bile particle, ensure the appearance system of final drug
One, it is beautiful.
Preferably, step(4)In, drying temperature is 60 ± 5 DEG C, per half an hour hydrofuge 5-10min, drying time 2-
3h, each hour are stirred once.
By using above-mentioned technical proposal, make soft grit, be gradually dehydrated, forms the particle that water content is 7% or so, and
Temperature is no more than 70 DEG C, and low energy consumption, reduces production cost.
Preferably, by step(4)The arisaema cum bile particle being prepared crosses 16 mesh sieve, and detection cholic acid content is 15% or more,
Obtain qualified arisaema cum bile particle.
By using above-mentioned technical proposal, ensures that the appearance of finished product medicament is neat and regular, promote the overall quality of medicament;
Ensure that the cholic acid content of finished product reaches code requirement.
Preferably, the animal gall powder is one or more in ox, sheep, Pulvis Fellis Suis;The making of the animal gall powder
Method is specially:Ox, sheep or pig's bile are concentrated under reduced pressure into thick paste, it is dry at a temperature of 80 DEG C, obtain animal gall powder;Animal gall powder
Middle cholic acid content is not less than 45%, and water content is no more than 7%.
By using above-mentioned technical proposal, bile is prepared into courage powder, courage powder yield in technique is determined, to calculate sample
Product cholic acid content and water content realize the purpose that animal gall powder quantitatively adds;Also, make cholic acid content in arisaema cum bile preparation process
Control it is more accurate.
Preferably, step(1)In further include Rhizoma Arisaematis (processed) pretreatment:It is cleaned and is selected to Rhizoma Arisaematis (processed), located
The Rhizoma Arisaematis (processed) that reason is completed enters subsequent processing.
By using above-mentioned technical proposal, when pretreatment, removal is rotten, mouldy Rhizoma Arisaematis (processed), and by Rhizoma Arisaematis (processed) table
The eliminations such as the sand dust in face promote the quality of finished product medicament.
The present invention also provides a kind of arisaema cum bile prepared slices of Chinese crude drugs being prepared by above-mentioned preparation method, in the arisaema cum bile
Medicine medicine materical crude slice is particle or tablet.
By using above-mentioned technical proposal, while ensure final drug beauty, by drug quantification, improves and use
Convenience;Overcome traditional manual cutting irregular shape, when use need to claim to weigh with weighing with a small steelyard, defect inconvenient to use.
In conclusion the present invention has the advantages that:
(1)Rhizoma Arisaematis (processed) is ground into the Ultramicro-powder of 1200 mesh, ensures medicinal powder powder diameter major part in 10um hereinafter, reducing
The irritation of drug(Toxicity), thoroughly solve the problems, such as that other methods process product toxicity not in place, ensure that the peace of product
Quan Xing;
(2)It is fed intake using courage powder, realizes the controllable purpose of main ingredient ratio that feeds intake;
(3)Final products are made to the form of particle or tablet, product appearance is beautiful, and dosage is accurate;Change traditional Chinese medicine drink
Black, big, the thick image of piece can be easier to be received by consumers in general.
Specific implementation mode
Below in conjunction with specific embodiment, invention is further described in detail.It should be understood that the embodiment of the present invention
The preparation method is only used for illustrating the present invention, rather than limiting the invention, right under the concept thereof of the present invention
The simple modifications of preparation method of the present invention belong to the scope of protection of present invention.
Used distilled water is the homemade distilled water in laboratory in the present invention, and bilein, Goat gall powder and Pulvis Fellis Suis pass through
Following methods are prepared:By healthy pig gall, ox courage, sheep courage, intimidating capsule releases bile.Two parts of pig's biles, two portions of sheep are taken respectively
Bile, two parts of fel bovis obtain 6 groups of bile, and respectively by operations described below, 6 groups of animal gall powders are prepared in 6 groups of bile:Yarn
Cloth filters, then at -0.1MPa, concentration is evaporated under reduced pressure, temperature is controlled 60 in being concentrated under reduced pressure in tank with one layer of calico filtering
℃;When water content is down to 40%-50%;It is placed in disk and makes thinner, dried at 80 DEG C, crush, sieve with 100 mesh sieve, weigh, count
Yield is calculated, the content and water content of cholic acid in courage powder are measured.As shown in table 1 below, the dosage of sample 1-6 animal biles is listed,
The yield of animal gall powder, cholic acid content and moisture.
The performance measurement of 1 sample 1-6 animal gall powders of table
Following data is determined according to the experimental result in table 1:Bile it is concentrated at courage powder yield be 9.5%-10.2%;Courage in courage powder
The content of acid is not less than 45%;According to cholic acid content detection as a result, determining that water should be controlled 7% hereinafter, therefore, selecting in courage powder
Courage powder prepared by Pulvis Fellis Suis 1, Goat gall powder 2 and bilein 2 ensures as animal gall powder used in the embodiment of the present invention from raw material
Root on improve product quality.
Embodiment 1
A kind of preparation method of the arisaema cum bile prepared slices of Chinese crude drugs, is prepared as follows:
(1)The sand and dust for removing Rhizoma Arisaematis (processed) surface select nothing and go bad, spare without mouldy Rhizoma Arisaematis (processed);
(2)It is crushed with micronizer by qualified Rhizoma Arisaematis (processed) is screened, crosses 1200 mesh mesh screens, it is micro- to obtain Rhizoma Arisaematis (processed)
Powder;
(3)Rhizoma Arisaematis (processed) micro mist 10kg, bilein 1kg are weighed, the two is sufficiently mixed and is stirred evenly using equivalent gradually-increased,
Obtain mixed powder;
(4)Using spray-on process, distilled water 2kg is sprayed on mixed powder, make mixed powder assemble to be formed hold it is agglomerating, touch i.e.
Scattered soft grit;
(5)After crossing 10-16 mesh screens to soft grit, soft grit is dehydrated with oscillating granulator, forming water content reduces
Particle;Above-mentioned particle is packed into baking pan, is put into drying box, drying temperature is 60 DEG C, and drying box air inducing is opened per half an hour
Switch, excludes moisture 8 minutes, and each hour is stirred once, 2 hours dry;It is all dry to particle;
(6)Arisaema cum bile particle after drying is sieved again, and it is 16 mesh to cross grit number, filters out the arisaema cum bile particle of whole grain, detects
Cholic acid content, 15% or more is the conforming particle for meeting Beijing's Chinese medicine preparation specification, and it is spare to select conforming particle;
(7)Qualified arisaema cum bile particle is pressed into bulk with tablet press machine, every piece of 3g obtains the tablet of finished product by metering packing
The arisaema cum bile prepared slices of Chinese crude drugs.
Embodiment 2
The preparation method of embodiment 2 and embodiment 1, difference lies in:
Step(3)In, Rhizoma Arisaematis (processed) micro mist 8kg, Goat gall powder 2kg are weighed, the two is sufficiently mixed and is stirred using equivalent gradually-increased
It mixes uniformly, obtains mixed powder;Step(4)In, using distilled water 3kg is sprayed on spraying normal direction mixed powder, make mixed powder
Aggregation forms agglomerating, the tactile i.e. scattered soft grit held;Step(5)In, particle loading baking pan is put into drying box, it is dry
Temperature is 60 DEG C, and drying box air inducing switch is opened per half an hour, excludes moisture 10 minutes, and each hour is stirred once, and dry 3 is small
When, until particle is all dry;Remaining operating procedure is consistent in embodiment 1.
Embodiment 3
The preparation method of embodiment 3 and embodiment 1, difference lies in:
Step(3)In, Rhizoma Arisaematis (processed) micro mist 6kg, Pulvis Fellis Suis 3kg are weighed, the two is sufficiently mixed and is stirred using equivalent gradually-increased
It mixes uniformly, obtains mixed powder;Step(4)In, using distilled water 1kg is sprayed on spraying normal direction mixed powder, make mixed powder
Aggregation forms agglomerating, the tactile i.e. scattered soft grit held;Step(5)In, particle loading baking pan is put into drying box, it is dry
Temperature is 60 DEG C, and drying box air inducing switch is opened per half an hour, excludes moisture 7 minutes, and each hour is stirred once, and dry 2 is small
When, until particle is all dry;Remaining operating procedure is consistent in embodiment 1.
Embodiment 4
The preparation method of embodiment 4 and embodiment 1, difference lies in:
Step(3)In, Rhizoma Arisaematis (processed) micro mist 10kg, Goat gall powder 1kg and Pulvis Fellis Suis 2kg are weighed, using equivalent gradually-increased by the two
It is sufficiently mixed and stirs evenly, obtain mixed powder;Step(4)In, using spraying normal direction mixed powder on spray distilled water
2.5kg makes mixed powder assemble agglomerating, the tactile i.e. scattered soft grit to be formed and be held;Step(5)In, particle is packed into baking pan
It is put into drying box, drying temperature is 60 DEG C, and drying box air inducing switch is opened per half an hour, excludes moisture 10 minutes, Mei Yi little
When stir it is primary, it is 2.5 hours dry, until particle is all dry;Remaining operating procedure is consistent in embodiment 1.
Embodiment 5
The preparation method of embodiment 5 and embodiment 1, difference lies in:
Step(3)In, Rhizoma Arisaematis (processed) micro mist 5kg is weighed, 2 parts, bilein 1kg, Pulvis Fellis Suis 2kg of Goat gall powder is progressively increased using equivalent
The two is sufficiently mixed and is stirred evenly by method, obtains mixed powder;Step(4)In, using spraying normal direction mixed powder on spray
Distilled water 2kg makes mixed powder assemble agglomerating, the tactile i.e. scattered soft grit to be formed and be held;Step(5)In, particle is packed into
Baking pan is put into drying box, and drying temperature is 60 DEG C, and drying box air inducing switch is opened per half an hour, excludes moisture 5 minutes, each
Hour stirs primary, drying 2 hours, until particle is all dry;Remaining operating procedure is consistent in embodiment 1.
Embodiment 6-10
Embodiment 6-10 lists the preparation method of arisaema cum bile particle, and embodiment 6 is corresponding with embodiment 1, embodiment 7 and embodiment
2 correspond to, and embodiment 3 is corresponding with embodiment 8, and embodiment 4 is corresponding with embodiment 9, and embodiment 5 is corresponding with embodiment 10, embodiment
6-10 is with the difference of embodiment 1-5 respectively:Embodiment 6-10 steps(7)In, by qualified arisaema cum bile particle by metering
Packing, every bag of 3g obtain the granular arisaema cum bile prepared slices of Chinese crude drugs of finished product.
The arisaema cum bile particle and tablet of the present invention, the micro- raw meat of gas, bitter, parenchyma cell similar round are full of gelatinized starch grain.Grass
Sour calcium raphides grows 10 μm or less.8~60 μm of spiral duct and annular duct diameter.The product 0.2g of Example 1-10, adds
Water 5ml shakes, and filtration takes filtrate 2ml to set in test tube, adds the furfuryl aldehyde solution of brand-new(1→100)0.5ml, along tube wall plus sulfuric acid
2ml shows reddish brown colour circle at two liquid borders, it was demonstrated that product is arisaema cum bile.
The performance of arisaema cum bile Chinese medicine of the present invention is as follows:Bitter, micro-pungent, it is cool.Return lung, liver, the spleen channel.Major function:Clearing heat and eliminating phlegm,
Dispelling wind and relieving convulsion;For phlegm-heat cough, expectoration Huang is thick, stroke and phlegm confusing heart, demented frightened epilepsy.Usage and dosage:3~6g/ times.Storage:It sets
It is mothproof at aeration-drying.
The arisaema cum bile particle or tablet of embodiment 1-10 are detected, determine cholic acid content in product, specific detection side
Method is as follows:
Sample is taken, No. four sieves are crossed(65 mesh), with the accurately weighed 1.0000 ± 0.0002g of the electronic balance of a ten thousandth, add ethyl alcohol
50ml is heated to reflux 2 hours, natural cooling, filtration;Filter residue is washed 2 times with a small amount of ethyl alcohol, merges ethanol twice, and
1-2ml is concentrated into water-bath;It is 15% sodium hydroxide solution 30ml to add mass concentration, and refluxing extraction 16 hours, natural cooling is simultaneously
It is transferred in separatory funnel, with 20ml distilled water, washing container, cleaning solution merge, be placed in same separatory funnel by several times;Add matter
The dilute sulfuric acid 35mL for measuring a concentration of 15% makes cleaning solution in acidity, and with ether shaking extraction 3 times, add diethyl ether 50ml every time, merges
Ether solution is placed in the evaporating dish of constant weight, in being evaporated to dryness in water-bath;It is dry to constant weight at 105 DEG C, cholic acid is calculated
Content, testing result is shown in Table 2.
With the moisture of product in moisture tester detection embodiment 1-10,2 are the results are shown in Table.
Comparative example 1
Using《Bulletin of Chinese materia medica》The 8th 472-473 pages of the phase of volume 11《The preparation method of arisaema cum bile is improved》In processing procedure and
Prescription prepares arisaema cum bile, Rhizoma Arisaematis (processed) 10kg, animal bile 60kg, liquor 0.2kg;Cholic acid content is shown in Table 2 in finished product arisaema cum bile
It is shown.
The testing result of cholic acid content in 2 arisaema cum bile of table
As shown in Table 2, the arisaema cum bile prepared slices of Chinese crude drugs for the particle and tablet that preparation method using the present invention obtains, cholic acid content is most
Up to 22.38%, cholic acid content and moisture meet States Pharmacopoeia specifications.Either particle or tablet, cholic acid content are steady
It is scheduled on 19% or so, it was demonstrated that product stability of the invention is good, and product quality is secure, safe.The product color of the present invention
It is brown color, pico- band fishy smell, either condition, color and luster or smell is first-class finished product.The particle and tablet of the present invention
Cholic acid content obviously higher than traditional processing procedure(Comparative example 1)Cholic acid content in obtained product(8.95%), reducing
In the case of inventory, cholic acid content is significantly promoted, the quality of arisaema cum bile tcm product is made to greatly improve.
The present invention overcomes traditional handicrafts to be fed intake with bile, the defect of product dosage inaccuracy;Bile is fed intake and becomes courage
Powder feeds intake, and defines the quality standard of courage powder, and 45% or more cholic acid content, moisture 7% is hereinafter, fundamentally control because feeding intake
Gap caused by and in main ingredient ratio reaches the stably and controllable consistency with product curative effect of product quality.The present invention uses courage
Cream powder feeds intake, and being mixed into softwood as adhesive using a small amount of water is directly prepared into particle drying, and batch products can be complete in 8 hours
At making life cycle of the product be greatly shortened, improve work efficiency.The present invention uses granulator granulation instead, direct after dry
Packing is tabletted, and full mechanization production keeps product dosage accurate, and product appearance is beautiful.
Above-mentioned specific embodiment is only explanation of the invention, is not limitation of the present invention, art technology
Personnel can as needed make the present embodiment the modification of not creative contribution after reading this specification, but as long as
It is all protected by Patent Law in scope of the presently claimed invention.
Claims (10)
1. a kind of preparation method of the arisaema cum bile prepared slices of Chinese crude drugs, it is characterised in that:It includes the following steps:
(1)The preparation of Rhizoma Arisaematis (processed) micro mist:Rhizoma Arisaematis (processed) is crushed, 1200 mesh sieve is crossed, obtains Rhizoma Arisaematis (processed) micro mist;
(2)It weighs and mixes:5-10 parts of Rhizoma Arisaematis (processed) micro mist is weighed, 1-5 parts of animal gall powder is mixed and stirred for uniformly, being mixed
Close medicinal powder;
(3)The preparation of soft grit:Distilled water is added on mixed powder, and mixed powder is made to assemble to form soft grit;
(4)The preparation of arisaema cum bile particle:Soft grit is dehydrated, is granulated, it is dry, obtain arisaema cum bile particle.
2. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, it is characterised in that:Step(2)In, weigh system
6-8 parts of rhizoma arisaematis micro mist, 2-3 parts of animal gall powder are mixed and stirred for uniformly, obtaining mixed powder.
3. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, it is characterised in that:Step(3)In, with spraying
Method sprays distilled water;The additive amount of the distilled water is 1-3 parts.
4. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, it is characterised in that:Step(4)In, to soft
It after particle crosses 10-16 mesh screens, is dehydrated, is granulated, it is dry, obtain arisaema cum bile particle.
5. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, it is characterised in that:Step(4)In, dry temperature
Degree is 60 ± 5 DEG C, and per half an hour hydrofuge 5-10min, drying time 2-3h, each hour is stirred once.
6. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, it is characterised in that:By step(4)It is prepared into
To arisaema cum bile particle cross 16 mesh sieve, detection cholic acid content is 15% or more, obtains qualified arisaema cum bile particle.
7. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, which is characterized in that the animal gall powder is
It is one or more in ox, sheep, Pulvis Fellis Suis;The production method of the animal gall powder is specially:Ox, sheep or pig's bile are depressurized dense
It shortens thick paste into, is dried at 80 DEG C, obtain animal gall powder;Cholic acid content is not less than 45% in animal gall powder, and water content is no more than 7%.
8. the preparation method of the arisaema cum bile prepared slices of Chinese crude drugs according to claim 1, which is characterized in that step(1)In further include
The pretreatment of Rhizoma Arisaematis (processed):It is cleaned and is selected to Rhizoma Arisaematis (processed), the Rhizoma Arisaematis (processed) for handling completion enters subsequent processing.
9. a kind of arisaema cum bile prepared slices of Chinese crude drugs prepared by claim 1-8 any one of them preparation methods.
10. the arisaema cum bile prepared slices of Chinese crude drugs according to claim 9, it is characterised in that:The arisaema cum bile prepared slices of Chinese crude drugs are particle
Or tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810862053.2A CN108785471A (en) | 2018-08-01 | 2018-08-01 | A kind of arisaema cum bile prepared slices of Chinese crude drugs and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810862053.2A CN108785471A (en) | 2018-08-01 | 2018-08-01 | A kind of arisaema cum bile prepared slices of Chinese crude drugs and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108785471A true CN108785471A (en) | 2018-11-13 |
Family
ID=64078878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810862053.2A Pending CN108785471A (en) | 2018-08-01 | 2018-08-01 | A kind of arisaema cum bile prepared slices of Chinese crude drugs and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108785471A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109316539A (en) * | 2018-11-23 | 2019-02-12 | 北京三和药业有限公司 | A kind of arisaema cum bile and its preparation process |
CN109674913A (en) * | 2019-02-28 | 2019-04-26 | 辽宁中医药大学 | A kind of technique that addition compound bacteria fermentation prepares arisaema cum bile |
CN111084838A (en) * | 2020-02-21 | 2020-05-01 | 河北国松堂制药有限公司 | Arisaema cum bile and preparation method thereof |
CN111407833A (en) * | 2019-11-29 | 2020-07-14 | 浙江桐君堂中药饮片有限公司 | Preparation method of arisaema cum bile |
CN111603527A (en) * | 2020-05-21 | 2020-09-01 | 北京紫云腾中药饮片有限公司 | Arisaema cum bile and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5959608A (en) * | 1982-09-28 | 1984-04-05 | Dai Ichi Seiyaku Co Ltd | Trichogenous agent |
CN101856443A (en) * | 2010-06-10 | 2010-10-13 | 药都制药集团股份有限公司 | Method for preparing Chinese patent medicament arisaema cum bile |
CN107596040A (en) * | 2017-10-13 | 2018-01-19 | 河南省三禾药业有限公司 | A kind of rhizoma arisaematis processed product and its concocting method |
-
2018
- 2018-08-01 CN CN201810862053.2A patent/CN108785471A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5959608A (en) * | 1982-09-28 | 1984-04-05 | Dai Ichi Seiyaku Co Ltd | Trichogenous agent |
CN101856443A (en) * | 2010-06-10 | 2010-10-13 | 药都制药集团股份有限公司 | Method for preparing Chinese patent medicament arisaema cum bile |
CN107596040A (en) * | 2017-10-13 | 2018-01-19 | 河南省三禾药业有限公司 | A kind of rhizoma arisaematis processed product and its concocting method |
Non-Patent Citations (4)
Title |
---|
山东医学院: "《脏器生化制药工艺学》", 31 January 1979, 山东医学院 * |
段启: "《中药饮片生产技术》", 31 August 2017, 广东高等教育出版社 * |
覃葆: "《中药炮制学》", 31 January 2012, 湖南科学技术出版社 * |
赵颖 等: "活血散超微粉与普通粉的显微特征鉴别研究", 《中国医院用药评价与分析》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109316539A (en) * | 2018-11-23 | 2019-02-12 | 北京三和药业有限公司 | A kind of arisaema cum bile and its preparation process |
CN109674913A (en) * | 2019-02-28 | 2019-04-26 | 辽宁中医药大学 | A kind of technique that addition compound bacteria fermentation prepares arisaema cum bile |
CN111407833A (en) * | 2019-11-29 | 2020-07-14 | 浙江桐君堂中药饮片有限公司 | Preparation method of arisaema cum bile |
CN111407833B (en) * | 2019-11-29 | 2021-11-16 | 浙江桐君堂中药饮片有限公司 | Preparation method of arisaema cum bile |
CN111084838A (en) * | 2020-02-21 | 2020-05-01 | 河北国松堂制药有限公司 | Arisaema cum bile and preparation method thereof |
CN111603527A (en) * | 2020-05-21 | 2020-09-01 | 北京紫云腾中药饮片有限公司 | Arisaema cum bile and preparation method and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108785471A (en) | A kind of arisaema cum bile prepared slices of Chinese crude drugs and preparation method thereof | |
JP7248778B2 (en) | Method for manufacturing additive-free herbal medicine cell wall-broken powder granules | |
CN102406760B (en) | Herba verbenae officinalis fluid decoction pieces and preparation method thereof | |
CN101785796B (en) | Method for preparing Jingan capsules | |
CN101249224B (en) | Method for improving vitamin C Yinqiao tablet stability | |
CN103356815B (en) | Forming method of granules for regulating qi and reducing phlegm | |
CN104857087A (en) | Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation | |
CN106924192A (en) | A kind of Chinese herbal granules and preparation method thereof | |
CN110755476B (en) | Method for separating and purifying antiallergic components in perilla leaves | |
CN102861131B (en) | A kind of six-ingredient clove tablet and preparation technology, detection method | |
CN106924291B (en) | Treatment method for mineral medicine or shell type traditional Chinese medicine | |
CN103070891A (en) | Capsule containing Hypericum perforatum extract | |
CN113318081A (en) | Ibuprofen granule and preparation method thereof | |
CN105582132A (en) | Preparation method and application of liquorice root formulation granules | |
CN112315931A (en) | Pentoxyverine citrate tablet and preparation method thereof | |
CN102908326B (en) | Asparagine tablet and preparation method thereof | |
CN106038620B (en) | A kind of preparation method of Folium Ginkgo | |
CN113491671A (en) | Preparation method of gardenia prescription granule | |
CN107951989A (en) | A kind of method moulded preparation method and prepare shenmai rehmannia pill | |
CN109620872B (en) | Granules of traditional Chinese medicine composition for reducing blood fat and softening blood vessels and granulation method thereof | |
CN109568468A (en) | A kind of dye yam granule and preparation method thereof | |
CN109303880A (en) | Smilax china L coated pellet and its preparation process | |
CN108553589A (en) | Capsule with dendrobium stem and preparation method thereof | |
CN107551248A (en) | A kind of ease pill and production technology | |
CN103690759B (en) | Compound liquorice-fritillarithunbergii-ammonium thunbergii-ammonium chloride medicinal composition and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181113 |