CN106913711A - Treat pharmaceutical composition of knee osteoarthritis and preparation method thereof - Google Patents

Treat pharmaceutical composition of knee osteoarthritis and preparation method thereof Download PDF

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Publication number
CN106913711A
CN106913711A CN201710292890.1A CN201710292890A CN106913711A CN 106913711 A CN106913711 A CN 106913711A CN 201710292890 A CN201710292890 A CN 201710292890A CN 106913711 A CN106913711 A CN 106913711A
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pharmaceutical composition
plant material
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桑志成
王海雄
桑灏祺
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

Pharmaceutical composition of knee osteoarthritis and preparation method thereof is treated this application discloses a kind of, extract of the described pharmaceutical composition comprising following plant materials is used as active component：The weight portion of 20 weight portion of the raw Radix Astragali 30, the weight portion of 9 weight portion of Poria cocos 12, the weight portion of 6 weight portion of rhizoma atractylodis macrocephalae 9, the weight portion of 3 weight portion of honey-fried licorice root 6, the weight portion of 6 weight portion of Ligusticum wallichii 10, the weight portion of 6 weight portion of Radix Angelicae Sinensis 9, the weight portion of 10 weight portion of stir-baked RADIX PAEONIAE ALBA 20, the weight portion of 10 weight portion of dogwood fruit 12 (or the weight portion of 9 weight portion of the root of bidentate achyranthes 15), the weight portion of 9 weight portion of optional Ramulus Taxilli 12, the weight portion of 10 weight portion of the bark of eucommia 15, the weight portion of 10 weight portion of the fruit of Chinese wolfberry 15 and the weight portion of 6 weight portion of levisticum 9.Through clinical usage, present invention treatment knee osteoarthritis card category speen-kidney dificiency has good efficacy.

Description

Treat pharmaceutical composition of knee osteoarthritis and preparation method thereof
Technical field
The application is related to the field of Chinese medicines, more particularly to a kind of Chinese medicine for treating knee osteoarthritis.
Background technology
Knee osteoarthritis (Knee Osteoarthritis, KOA) are cartilage degeneration and abrasion, and spur formed, Symptoms are gonalgia, stiff, lopsided and dysfunction, and symptom is aggravated in chronic, progressive.It is also called knee joint increasing Natural disposition arthritis, senescent arthritis, DA etc..Epidemiology survey data shows the disease in China the elderly In the incidence of disease more than 60%, drastically influence the quality of life of mid-aged population, it has also become serious society and economy are asked Topic.This sick therapeutic purposes is pain of alleviation, prevents and delay the progress of disease, and Saving cortilage function, quality of making the life better are controlled Western medical treatment includes non-drug therapy health education, motion and Life Guidance, various physical treatments in treatment, and medicine has symptom management Medicine, osteoarthritis make medication and Chondroprotective agents slowly, and lesion seriously and the patient of function of joint serious hindrance uses joint more The surgical interventions such as videoendoscopic surgery, artificial joint replacement.Wherein non-operative treatment based on symptom treatment, including anti-inflammatory analgesic medicine and The application of nonsteroidal anti-inflammatory (NSAIDs).And Chinese traditional treatment KOA methods are various, determined curative effect, adverse reaction is few, is facing It is used widely in bed.
Knee osteoarthritis are Bones and joints section frequently-occurring disease, common disease, and patient is mainly the elderly,《Osteoarthritis diagnose and Treatment guidelines (2010)》Point out, up to 50%, the crowd of 75 years old then reaches illness rate in the osteoarthritis crowd of more than 60 years old 80%, and have certain disability rate, it is the big factor for having a strong impact on life of elderly person quality.Counted according to related data, this disease Increase with the age, incidence trend is in be gradually increasing trend.According to another scholar on knee osteoarthritis of elder patients ' life quality influence because Element is analyzed after drawing and finds, for old KOA patient, in addition to KOA diseases in itself pain, the course of disease, walking ability, internal medicine Chronic disease number is also the principal element for influenceing its quality of life, and wherein gonalgia is important factor in order.Face according to the author It has been observed that in severe KOA patient in bed, the old artificial overwhelming majority, wherein simultaneously with hypertension, coronary heart disease, diabetes, The patient of the other systems chronic disease such as chronic renal insufficiency is not within minority, and such case not only influences patients ' life quality, The difficulty of medicine and the selection of various therapies is increased simultaneously.
In China, due to lacking corresponding health propaganda and education to KOA, most patient's lesion has developed to mid-term even when medical Late period, the painful swelling of joints of chronic progressive, lopsided and limitation of activity are had outstanding performance.For severe KOA, often needed in western medical treatment Wanting artificial knee replacement surgery could obtain satisfied curative effect；But a portion patient or because of health or because of economy Reason is reluctant to receive artificial knee joint replacement and the state of an illness can not persistently be alleviated, therefore takes conservative treatment, it is desirable to which the state of an illness also can A certain degree of improvement is obtained, and the main selection of conservative treatment is exactly tcm therapy.
Knee osteoarthritis are diagnosed for doctor trained in Western medicine, and knee numbness disease or kneecap numbness are referred to as current tcm diagnosis more.Though knee osteoarthritis belong to Numbness disease category, outside wind-cold-dampness arthralgia, modern doctor to its interpretation of the cause, onset and process of an illness understanding more difference, be in brief void, the stasis of blood, heresy three, In clinical treatment and research or select one two medicine sent with prescription of making laws, or and and control it, or diagnosis and treatment differs and same；With side Ancient prescription is held on upper or edge, or sincerely follows Chinese medical discrimination voluntarily prescription, and knee osteoarthritis are treated using traditional Chinese medical science folk prescription, achieves good treatment Effect, while seldom there is adverse reaction.
This oral medicinal herb treatment knee osteoarthritis can curative effect reliability, toxic and side effect is relatively small, relative to Chinese medicine acupuncture, push away It is convenient and swift by, the therapy such as external washout with traditional Chinese herbs, herbal ion penetration, there is its unique advantage.Be used alone or coordinate traditional Chinese and western medicine other Method has different degrees of improvement result to the Human Osteoarthritis state of an illness.
The content of the invention
Present invention aim at the state of an illness for improving knee osteoarthritis, as one kind of knee osteoarthritis expectant treatment method, Independent or auxiliary treatment knee osteoarthritis, mitigate knee osteoarthritis symptom, improve curative effect.
This application provides a kind of pharmaceutical composition for treating knee osteoarthritis, the extract comprising following plant materials is made It is active component：
The raw weight portion of 20 weight portion of the Radix Astragali -30, the weight portion of 9 weight portion of Poria cocos -12, the weight portion of 6 weight portion of rhizoma atractylodis macrocephalae -9, process The weight portion of 3 weight portion of Radix Glycyrrhizae-6, the weight portion of 6 weight portion of Ligusticum wallichii-10, the weight portion of 6 weight portion of Radix Angelicae Sinensis-9, the weight portion of stir-baked RADIX PAEONIAE ALBA 10- 20 weight portions, the weight portion of 10 weight portion of dogwood fruit -12 (or the weight portion of 9 weight portion of the root of bidentate achyranthes -15), the weight of 9 weight portion of Ramulus Taxilli -12 Part, the weight portion of 10 weight portion of the bark of eucommia -15, the weight portion of 10 weight portion of the fruit of Chinese wolfberry -15 and the weight portion of 6 weight portion of levisticum -9.For in Doctor is diagnosed as the patient of knee numbness disease or kneecap numbness, or doctor trained in Western medicine is diagnosed as the patient of knee osteoarthritis, can use the medicine group Compound is treated, and can mitigate the symptom of knee osteoarthritis, improves the living standard of patient.
There is the serious patient of soreness and weakness of waist and knees, lower limb chilly for main suit, the plant material can further include fructus alpiniae oxyphyllae The weight portion of 10 weight portion -15 or the weight portion of 10 weight portion of Semen Cuscutae -15 or the weight portion of 10 weight portion of teasel root -15.That is, right In the patient for further having soreness and weakness of waist and knees, lower limb chilly symptom, on the basis of above-mentioned essential drugs, 10 weight can be added The teasel root of -15 weight portion fructus alpiniae oxyphyllaes of part or the weight portion Semen Cuscutae of 10 weight portion -15 or the weight portion of 10 weight portion -15.Intelligence development Benevolence temperature spleen warms up kidney, astringent sperm contracting urine, treats all diseases of malaria kidney deficiency, Semen Cuscutae filling liver kidney, benefiting quintessence, and teasel root filling liver kidney, strengthening the bones and muscles are controlled The soreness of waist and knee joint of kidney deficiency and liver is treated, three medicines are warm in nature, have supporing yang work(, with dogwood fruit, the bark of eucommia, Ramulus Taxilli, all medicine phases of the fruit of Chinese wolfberry 5, enhancing filling liver kidney, the work(of strong waist knee, so as to alleviate all diseases of knee rheumatism.
For the patient of white and greasy fur, the plant material can further include the weight portion of 10 weight portion of Semen Coicis Semen Coicis -20 Or the weight portion of fructus amomi 6.White and greasy fur be damp evil it is viscous as Semen Coicis Semen Coicis invigorating the spleen, tonifying lung, heat-clearing, dampness removing can control the muscle of arthritis with fixed pain caused by dampness Arteries and veins contraction, joint stuffiness, fructus amomi temperature spleen dampness elimination can control the card of resistance in deficiency-cold in spleen and stomach, damp evil, two medicines select first, with above-mentioned main ingredient Middle Poria cocos, the bighead atractylodes rhizome coordinate, and the work(of invigorating the spleen to clear away damp pathogen is played altogether.
For the patient of yellow and greasy fur, the plant material can further include the weight portion of the coptis 3 or the weight portion of caulis bambusae in taenian 6 or life Coix seed 10-30 weight portions.The main retention of damp-heat in the interior of yellowish greasy tongue, and the coptis specializes in heat-clearing and damp-drying drug, is apt to clear dampness-heat in middle jiao, caulis bambusae in taenian is micro- It is cold, there is the work(of clearing heat and eliminating phlegm relieving restlessness.
The patient for having an indentation fat for spiritlessness and weakness and tongue, the plant material further includes Chinese yam or Radix Codonopsis or crown prince Ginseng, preferred content is the weight portion of 9 weight portion of Chinese yam -12 or the weight portion of 9 weight portion of Radix Codonopsis -12 or radix pseudostellariae 6-12 weight portions.Suffer from Person's spleen kidney qi deficiency, is shown in the fat product for having all diseases of indentation, selecting QI invigorating of spiritlessness and weakness, tongue, or Chinese yam or Radix Codonopsis or radix pseudostellariae, coordinates master The medicine such as the Radix Astragali, bighead atractylodes rhizome, tonifying middle-Jiao and Qi in medicine, help spleen transporting, muscle muscles and bones of supplementing nutrition.
For dry throat, dry, feverishness in palms and soles patient, the plant material further includes radix glehniae and the tuber of dwarf lilyturf or the stem of noble dendrobium Or the dried rhizome of rehmannia or radix scrophulariae, preferably include the weight portion of 10 weight portion of radix glehniae -15 and the weight portion of 10 weight portion of the tuber of dwarf lilyturf -20, or the stem of noble dendrobium The weight portion of 10 weight portion -20, or the weight portion of 10 weight portion of the dried rhizome of rehmannia -15, or the weight portion of 10 weight portion of radix scrophulariae -15, radix glehniae, the tuber of dwarf lilyturf There is the work(of fluid dryness, more simultaneous heat-clearing outside the dried rhizome of rehmannia, radix scrophulariae yin-nourishing, with being adjutant, treats dry, dry throat, feverishness in palms and soles Disease.
For painful swelling of joints severe patient, the plant material further includes golden cypress and rhizoma atractylodis Huo Bi Collettiis or rhizoma alismatis or pool Orchid, preferably includes the weight portion of 6 weight portion of golden cypress -9 and the weight portion of 6 weight portion of rhizoma atractylodis -15, the weight portion of 10 weight portion of Huo Bi Collettiis -15, Or the weight portion of 10 weight portion of rhizoma alismatis -12 or the weight portion of 10 weight portion of Herba Lycopi -12.Damp and hot heresy streamer knee joint, it is swelling to send out, and Knee joint part skin temperature rise is caused, pain is write especially, and golden cypress, the medicine 5 of rhizoma atractylodis two are used, more write the effect of heat-clearing and damp-drying drug invigorating the spleen, and work(is special Under, for treating the arthralgia and myalgia that damp invasion of lower energizer causes, Bi Collettii dampness removing removes turbid, wind and relieving paralysis of dispelling.Dampness removing removes turbid, wind expelling stagnation removing, Arthralgia pain due to rheumatism can be controlled, articular instability, lumbocrural pain, rhizoma alismatis clearing damp and promoting diuresis, Herba Lycopi's line water detumescence, the application of selection one or two is sharp with heat-clearing Wet detumescence, swelling disappears, and pain is gradually removed.
, patient that contraction serious heavy for lower limb, the plant material further includes the root of Chinese clematis or pawpaw or stretches muscle Grass plays both sides of the street, and preferably includes the weight portion of 10 weight portion of the root of Chinese clematis -15, the weight portion of 9 weight portion of pawpaw -12, the weight of lycopodium calvatum 9 Part -15 weight portions, play both sides of the street the weight portion of 9 weight portion -12.The root of Chinese clematis can wind-damp dispelling, remove obstruction in channels to relieve pain, disappear bone sticking, pawpaw relaxing muscles and tendons It is active, lycopodium calvatum expelling wind and clearing away cold, dehumidification swelling, relax the muscles and stimulate the blood circulation, play both sides of the street dispelling wind and removing obstruction in the meridians, Li Shui dehumidifying, heavy for lower limb, inflexible The serious patient of contraction, it is necessary to various medicine collective effects with dispelling, collateral-activating function, quickly to release the pain of patient.
, tongue obvious for pain secretly has the patient of the stasis of blood, and the plant material further includes the red sage root or reticulate millettia or pseudo-ginseng, Preferably include the weight portion of 15 weight portion of the red sage root -20, the weight portion of 15 weight portion of reticulate millettia -20, or the weight portion of 3 weight portion of pseudo-ginseng -6, The weight portion of corydalis tuber 10, the weight portion of 6 weight portion of rhizoma cyperi -9.Stagnation of blood stasis is shown in that pain is obvious, the dark all diseases of tongue in knee, from chicken blood The product of rattan, the red sage root, pseudo-ginseng, corydalis tuber, rhizoma cyperi etc promoting qi circulation and relieving pain promoting blood circulation and removing blood stasis more preferably to release the pain that stasis of blood numbness is brought, with main ingredient The cooperation of middle Ligusticum wallichii, even more collaboration increased the effect of medicine.
For the patient of vexed, forgetful insomnia, the plant material further includes the vine of multiflower knotweed or stir-baked SEMEN ZIZIPHI SPINOSAE or polygala, Preferably include the weight portion of 10 weight portion of the vine of multiflower knotweed -15 or stir-baked SEMEN ZIZIPHI SPINOSAE 10-15 weight portions, polygala 10-15 weight portions.Vine of multiflower knotweed nourishing heart Calm the nerves, dispelling wind and removing obstruction in the meridians, spina date seed nourishing the liver antitoxic heart-soothing and sedative, polygala antitoxic heart-soothing and sedative, to improve patient's mood, sleep quality, more The knee joint state of an illness is conducive to recover.
In addition, can also add dried orange peel in above-mentioned plant material, dried orange peel regulating qi-flowing for strengthening spleen, eliminating dampness in tune can be prevented major-minor Medicine is excessively nourished and hinders stomach.
Present invention also offers prepare aforementioned pharmaceutical compositions method, preferably described weight portion for gram, by the plant After raw material is by the mixing of above-mentioned weight portion, according to every pair of medicine 300-500ml, preferably 400ml amount of liquid medicine+20% is damaged water consumption calculation and is added Water, liquid is prepared using boiling machine；Or take the single herbal concentrate-granule of the plant material, the specific needs according to patient according to Above-mentioned weight mixing, the weight portion for gram, mixture obtained by the water dissolves with temperature at 92 to 100 degrees Celsius.
Specific embodiment
Inventor combines knee osteoarthritis clinical treatment experience for many years, it is believed that in addition to the factors such as other are congenital, wound, for a long time Strain is the key factor of knee osteoarthritis morbidity,《The Yellow Emperor's Canon of Internal Medicine Plain Questions declares five gas》In have " prolonged sitting injuring the muscles, it is vertical long The opinion of the injury of the bone, prolonged walking injuring tendons ", the motion in human body limb joint, the systolic and diastolic function of muscle is first, muscle is in muscle, joint in addition Between play synergy, therefore speech " penis main beam bone and profit office ", muscle, muscle, bone maintain the normal function in joint jointly, existing The long-term improperly seat of generation life and it is excessive or improperly walk, accumulation strain of standing causes the pain of joint part, and then goes out Existing dysfunction, deformity.Spleen governing muscles four limbs, liver governing tendons, Shen controls bone.Taste are reservoir of food and drink, and source of generating QI and blood, taste are good for It is prosperous, change source abundance, qi and blood is filled, then liver has grown, and muscle, muscle, bone have moistened foster.The change of modern life dietary structure, it is many Fatness, sweet, thick and oily, spleen is easily stranded by wet, or ferritic is weakness of the spleen and the stomach, then the biochemical weary source of qi and blood, changes source deficiency, and muscle, muscle, bone lose it Support, and cause limbs joint weak and feeble, or even useless use.Insufficiency of generating and transforming QI and blood, runs powerless, stagnation of blood stasis part, and causes to close Section pain.Middle-older patient with age, along with caused by liver and kidney deficiency.Inventor sums up speen-kidney dificiency for knee osteoarthritis Basic pathogenesis, be mainly characterized in that asthenia in origin and asthenia in superficiality, simulataneous insufficiency and excessive, this void is core, and folder is with real, its morbidity such as blood stasis, water is wet Process is dirty closely related with spleen, liver, kidney three, and with kidney and spleen invigorating, based on qi and activate blood circulation, prescription uses medicine group of the invention to the rules for the treatment of Compound, i.e. Bushen Jianpi Huoxue recipe are added and subtracted with disease.
Specifically, Bushen Jianpi Huoxue recipe of the invention is as follows：
Retrieved through China of State Administration of Traditional Chinese Medicine traditional Chinese medicine information retrieval center document Investigation, do not find and use and this hair The research report of bright medicament composing prescription identical compound of Chinese herbal medicine knee osteoarthritis/kneecap numbness.
Chinese medicine with other treatment osteoarthritis is compared, the uniqueness of pharmaceutical composition (also referred to as kidney and spleen invigorating side) of the invention Part is shown from the morbidity root of osteoarthritis starts with, on the basis of speen-kidney dificiency is for the basic pathogenesis of knee osteoarthritis, plus Upper QI invigorating, dredging collateral and blood circulation promoting medicine.The Fang Zhongsheng Radixs Astragali, the bighead atractylodes rhizome, Poria cocos, honey-fried licorice root is main medicine air making-up and spleen enlivening, the raw Radix Astragali, Wen Wei It is sweet, reuse with tonifying Qi, above up to lower logical, invigorating qi for consolidating superficies, anti-evil invasion, tonneau battalion defends, and can subside a swelling, and controls the not all right numbness of blood stagnancy due to deficiency of QI Bitterly.The bitter temperature of the bighead atractylodes rhizome, invigorating the spleen to dry, QI invigorating helps fortune；Poria cocos is sweet light, invigorating the spleen excreting dampness；Siberian cocklebur art is shared, and invigorating the spleen to clear away damp pathogen is more imitated.Honey-fried licorice root With in, coordinating the drug actions of a prescription shares the evident work(for replenishing qi to invigorate the spleen to QI invigorating with the Radix Astragali, the bighead atractylodes rhizome, Poria cocos.
Dogwood fruit, the bark of eucommia, Ramulus Taxilli, the root of bidentate achyranthes, matrimony vine, kidney tonifying strong waist knee is adjuvant in side, and Ramulus Taxilli bitter but sweet flavor is mild-natured, Filling liver kidney, strengthening the bones and muscles, wind-damp dispelling.The sweet micro-pungent of the bark of eucommia, it is warm in nature, it is to control caused by liver and kidney deficiency, long numbness soreness of waist and knee joint, weak key medicine. Dogwood fruit is sour bitter and puckery, slightly warm in nature, tonifies the liver and kidney, and arrest sweating benefit is cloudy；The fruit of Chinese wolfberry is sweet mild-natured, filling liver kidney and kidney-nourishing the yang aspect of yang. Root of bidentate achyranthes bitter is acid flat, and energy filling liver kidney, strengthening the bones and muscles, scattered blood stasis go down burnt enter liver kidney, and can ensuring proper downward flow of the blood eliminating impediment.All medicines share is mended Kidney is simultaneous with eliminating impediment.
Ligusticum wallichii, Radix Angelicae Sinensis, the root of herbaceous peony be side in adjutant nourshing blood and promoting blood circulation, replenish qi to invigorate the spleen, Radix Angelicae Sinensis acrid-sweet flavor slight bitter, warm in nature, work of enriching blood Blood, cold dispelling, swelling and pain relieving cures mainly joint stuffiness, the pain card of wind chill blockage；Stir-baked RADIX PAEONIAE ALBA is sweet bitter, cold nature, and blood-nourishing is flourish Muscle, relieving spasm to stop pain；Ligusticum wallichii taste is pungent is warm in nature, is the gas medicine blood-activating and qi-promoting in blood.Levisticum taste is pungent is warm in nature, and expelling wind and eliminating dampness, priming makes it It is descending；Corydalis tuber promoting blood circulation, promoting the circulation of qi, analgesic, coordinate levisticum, Ramulus Taxilli with numbness relieving and pain relieving.Full side's filling liver kidney, strengthening the bones and muscles, replenish qi to invigorate the spleen, Promoting blood circulation and stopping pain, mends without stagnant, grows and oiliness.Through clinical usage, we's treatment knee osteoarthritis card category speen-kidney dificiency has good treatment Effect.
In addition, there is the patient of other symptoms for some, whole pharmaceutical composition can be reconciled plus other Chinese medicines Effectiveness, carries out therapeutic effect of the dialectical plus-minus to be optimal：Soreness and weakness of waist and knees, lower limb chilly notably separately add fructus alpiniae oxyphyllae, Semen Cuscutae Or teasel root etc., from Semen Coicis Semen Coicis or fructus amomi etc., yellow and greasy fur person adds the coptis, caulis bambusae in taenian or Semen Coicis Semen Coicis etc. to white and greasy fur person, and god is tired Weak and tongue is fat, and the person that has indentation adds with Chinese yam, Radix Codonopsis or radix pseudostellariae etc., and dry throat, dry, feverishness in palms and soles etc. are drunk plus radix glehniae, the tuber of dwarf lilyturf Or the stem of noble dendrobium etc., painful swelling of joints person from golden cypress, rhizoma atractylodis Huo Bi Collettiis etc., lower limb are heavy, contraction notably from the root of Chinese clematis, pawpaw, stretch Muscle grass or play both sides of the street etc., pain substantially, tongue secretly there is stasis of blood person to add with the red sage root, reticulate millettia or pseudo-ginseng etc..For vexed, forgetful, insomnia Patient, the plant material further includes the vine of multiflower knotweed or stir-baked SEMEN ZIZIPHI SPINOSAE or polygala.These medicines are worked in coordination with above-mentioned main ingredient, Further can more efficiently suit the medicine to the illness and treat, the slight illness of reduction of patient.
Separately it was found that active ingredient Cornus officinalis plantations have immunological regulation and anti-inflammatory in kidney and spleen invigorating side's taste of traditional Chinese medicine dogwood fruit Effect, radix paeoniae alba extraction significantly inhibits effect to rat egg white acute inflammation, makees with obvious anti-inflammatory and immunological regulation With the collaboration of the two compatibility effect can strengthen its immunological regulation and antiinflammatory action；Another root of herbaceous peony Radix Glycyrrhizae 5 is used, and name says Chinese herbaceous peony Radix Glycyrrhizae Soup, modern study confirms that peony and licorice decoction has obvious antiinflammatory action, and the Radix Astragali fruit of Chinese wolfberry has certain in Bushen Jianpi Huoxue recipe Antifatigue effect.The fruit of Chinese wolfberry can strengthen body muscle power, rapid elimination post exercise fatigue.The bark of eucommia in side, the root of bidentate achyranthes, dogwood fruit, The medicines such as the fruit of Chinese wolfberry have the function of filling liver kidney, strengthening the bones and muscles, strong waist knee.
Bushen Jianpi Huoxue recipe of the invention is used alone or coordinates traditional Chinese and western medicine other treatment method, can be to kneecap joint Scorching conditions of patients (including symptom and sign) has a certain degree of therapeutic effect.In order to illustrate effect of the invention, attached case is such as Under：
Case 1：Patient, female, 62 years old, on March 4th, 2014, head was examined.Double knee pain companion pains in the back more than 10 years, aggravate 2 months, Walking is goinyalgia occur less than 1km, and taking a load off one's feet, the pain increased, squats down limited, feels soreness and weakness of waist and knees, and cold, dry is difficult out Sweat, abundant expectoration from morning, two just adjust, diet can, insomnia with a lot of dreams, dimly red tongue.Have a medical check-up：Double knee joint mild swelling, local skin temperature is not Height, double knee medial gaps tenderness (+), knee articulation is limited, and passive activity bends and stretches 140 ° without bright limited on the left of active movement, 150 ° of right side.Tongue fur root is greasy in vain, and anterior tongue is few, deep thready pulse.Row bone density checks that T values are -2.7.Successively give benefit of the invention Kidney and strengthening spleen blood circulation promoting recipe adds 28 pairs of taste to take, and is paid a return visit after 1 first quarter moon, and, without significant discomfort, basic living is freely for knee joint.Specific place Side is as follows：
It is decocted in water for oral dose, daily 1 dose, divides 2 times and warmly take.
The medicament increased nourishing blood and tranquilization, the vine of multiflower knotweed of wind dispelling dredging collateral on the basis of said medicine, further optimize Therapeutic effect.
Case 2：Certain female, 63 years old, head was examined within 2 11st, 2014.Right gonalgia more than 10 years, this time aggravates 1 month, companion There are obvious tumefaction and limitation of activity, feel that lower limb are heavy, walk with difficulty.Difference of sleeping just is done, and dry is not intended to drink.X-ray film：Right knee joint Regression, joint space narrows, capsular ligament swelling.Tongue vein：Tongue nature is light, and root tongue is greasy in vain, slippery and rapid pulse.Successively give kidney tonifying of the invention Jianpi Huoxue Decoction adds 21 pairs of taste single herbal concentrate-granule to take, and right knee swelling pain is relieved, activity rear right knee slightly powerlessness. Specific prescription is following (single herbal concentrate-granule)：
Mixing in water for oral taking, day is one, and 2 times a day warmly takes.
Outside aforementioned pharmaceutical compositions of the present invention, rhizoma alismatis and stir-baked SEMEN ZIZIPHI SPINOSAE are further added, the Li Shui using rhizoma alismatis disappears Effect and stir-baked SEMEN ZIZIPHI SPINOSAE nourishing the liver calming heart that swollen, excreting dampness expels the heat-evil, the effect for arrest sweating of calming the nerves.
Case 3：Certain female, 51 years old, first visit on the 14th in 2 months in 2015.Right gonalgia, contraction is unfavorable, dropping, mouth It is dry, thirsty.Look into：There is tenderness in joint without obvious tumefaction, knee inner side and rear side, and passive activity is fine.X-ray：Right knee regression, joint Capsule mild swelling.Head is examined and is given 7 pairs of Bushen Jianpi Huoxue recipe plus taste single herbal concentrate-granule to take, and specific prescription is following (to exempt to decoct particle Agent)：
Mixing in water for oral taking, day is one, and 2 times a day warmly takes.
Two examine pain contraction makes moderate progress, and Herba Lycopi, radix scrophulariae, plus Semen Coicis Semen Coicis 15g, 7 pairs of following the services are removed in front.Three examine knee pass Section is without obvious pain, and slight contraction is uncomfortable.
In this case, first with Herba Lycopi's promoting blood circulation water-filling, radix scrophulariae enriching yin, fall fire, relieving restlessness, effect of removing toxic substances coordinates remaining main ingredient, delays Solution pain contraction.Semen Coicis Semen Coicis increase dehumidifying effect is used instead after removing Herba Lycopi, radix scrophulariae again, finally treat the knee osteoarthritis of the patient.
Patient Nie of case 4. so-and-so, female, 68 years old, the first visit on the 03rd of September in 2013.Main suit's gonalgia, pain in the back more than 3 years, Nearly exacerbation of symptoms, knee joint joint stuffiness, difficulty in walking over the past half year.Patient's chilly usually, sweating, xerophtalmia, it is poor to sleep, and receives and eats still Can, two just adjust, and tongue is weak is slightly fat, there is crackle, and yellow,greasy and thin fur, the tongue bottom train of thought stasis of blood is bent, wiry and frequent pulse, right chi forceless deep pulse.Have a medical check-up：Knee joint Mobility reduces, local without tenderness.X-ray shows：Double kneecap joints degenerative change, lumbar vertebrae hyperosteogeny, part narrowing of intervertebral space.
Prescription：Raw Radix Astragali 20g Poria cocos 10g rhizoma atractylodis macrocephalae 9g Radix Glycyrrhizaes 6g
Coptis 3g tuber of dwarf lilyturf 10g Ramulus Taxilli 10g barks of eucommia 12g
Root of bidentate achyranthes 10g Ligusticum wallichii 10g red sage root 15g fruits of Chinese wolfberry 15g
Root of herbaceous peony 20g Chinese yam 10g rhizoma cyperi 6g corydalis tubers 10g
7 doses of Semen Coicis Semen Coicis 15g Radix Angelicae Sinensis 6g teasel root 12g radix glehniaes 10g, is decocted in water for oral dose, and warmly takes for 2 times one point of day
Successively take 21 doses of follow-ups, patient articular's pain symptom improves obvious, the dry symptom of chilly, mesh takes a turn for the better, sleep quality compared with Before make moderate progress.
The Yang of case 5., female, 52 years old, the first visit of October 15 in 2013.Main suit double knee joint pain 2 weeks.Inscribe symptoms include： Double knee pain, joint stuffiness, chilly, tinnitus, addiction meat or fish, few when many during appetite usually, dormancy can, two just adjust, and tongue is weak is fat, and tongue is white It is greasy, wiry and rolling pulse.X-ray film shows：Double knee osteoarthritis.
With side：Dried orange peel 9g Poria cocos 10g Radix Glycyrrhizae 6g caulis bambusae in taenians 10g
Red sage root 15g rhizoma cyperi 6g corydalis tubers 10g tubers of dwarf lilyturf 10g
Rhizoma atractylodis macrocephalae 9g root of herbaceous peony 20g Radix Astragali 30g levisticums 6g
Root of bidentate achyranthes 10g Ligusticum wallichii 10g root of Chinese clematis 10g Semen Coicis Semen Coicis 20g
Rhizoma atractylodis 6g fruit of Chinese wolfberry 15g bark of eucommia 10g Ramulus Taxilli 10g
3 doses of golden cypress 6g, is decocted in water for oral dose, and warmly takes for 2 times one point of day
17 doses of follow-ups successively are taken, double knee pain joint stuffiness symptoms are relieved.
Case 6, certain patient main suit's gonalgia, head are examined and are given pharmaceutical composition of the present invention, and wherein plant material contains Following medicine：
Raw Radix Astragali 20g, Poria cocos 9g, rhizoma atractylodis macrocephalae 6g, honey-fried licorice root 3g, Ligusticum wallichii 6g, Radix Angelicae Sinensis 6g, stir-baked RADIX PAEONIAE ALBA 10g, dogwood fruit 10g, Ramulus Taxilli 9g, bark of eucommia 10g, fruit of Chinese wolfberry 10g and levisticum 6g, every kind of medicine take single herbal concentrate-granule, mix according to above-mentioned weight, advise use It is oral after the medicine of 92 degrees Celsius to 100 degrees Celsius of water dissolves mixing.
One portion per day, takes medicine continuously further consultation after seven days, and symptom mitigates significantly.
Case 7,
Certain patient, main suit's gonalgia, and with soreness and weakness of waist and knees, lower limb chilly is serious, take with following compositions and The pharmaceutical composition of content, is boiled medicine to specifications using boiling machine：
Raw Radix Astragali 20g, Poria cocos 9g, rhizoma atractylodis macrocephalae 6g, honey-fried licorice root 3g, Ligusticum wallichii 6g, Radix Angelicae Sinensis 6g, stir-baked RADIX PAEONIAE ALBA 10g, root of bidentate achyranthes 9g, mulberry Parasitic 9g, bark of eucommia 10g, fruit of Chinese wolfberry 10g, levisticum 6g and fructus alpiniae oxyphyllae 10g.
One portion per day, takes medicine continuously further consultation after seven days, and symptom mitigates significantly.
Case 8,
Certain patient, main suit's gonalgia, and with spiritlessness and weakness, lingual diagnosis finds that tongue is fat indentation, takes with following The pharmaceutical composition of composition and content, is boiled medicine to specifications using boiling machine：
Raw Radix Astragali 30g, Poria cocos 12g, rhizoma atractylodis macrocephalae 9g, honey-fried licorice root 6g, Ligusticum wallichii 10g, Radix Angelicae Sinensis 9g, stir-baked RADIX PAEONIAE ALBA 20g, root of bidentate achyranthes 15g, Ramulus Taxilli 12g, bark of eucommia 15g, fruit of Chinese wolfberry 15g, levisticum 9g and Chinese yam 12g.
One portion per day, takes medicine continuously further consultation after seven days, and symptom mitigates significantly.Summary case is visible, in base of the present invention On the basis of plinth side, corresponding medicine is added and subtracted according to specific symptom, the optimum efficiency for the treatment of can be obtained.
Another inventor carries out 60 clinical case observations, chooses meet rheumatology branch of Chinese Medical Association knee in 2010 altogether OA criteria for classification clinical criterias, and age >=46 year old ,≤80 years old, Kellgren-Lawrence radiodiagnostics was classified as III level And IV grades, knee osteoarthritis severity index (ISOA) scores >=8 points of severe KOA patient, women 51, male 9, and totally 60 Example patient.Treatment group 32, control group 28 carries out observation of curative effect.
Comparative example
Above-mentioned control group uses health education and psychological counseling, loxoprofen sodium tablets (trade name：Happy pine, the one or three makes altogether Medicine (Shanghai) Co., Ltd. produces, Chinese medicines quasi-word H20030769, specification：60mg × 20 piece.Orally, 3 times a day, one at a time, In aftermeals), aminoglucose hydrochloride capsule (trade name：Portugal is stood, Shanxi Zhong Yuanwei pharmaceutcal corporation, Ltds, Chinese medicines quasi-word H20020306, specification 0.24g × 42, orally, 2 every time, 3 times a day).
Embodiment
Above-mentioned treatment group combines that Bushen Jianpi Huoxue recipe is for oral administration (to be configured, daily by granule pharmacy on the basis of control group One, point warmly take for 2 times sooner or later), its square foundation is made a living Radix Astragali 20g, Poria cocos 10g, rhizoma atractylodis macrocephalae 9g, honey-fried licorice root 6g, Ligusticum wallichii 10g, when Return 9g, stir-baked RADIX PAEONIAE ALBA 20g, dogwood fruit 10g, root of bidentate achyranthes 10g, Ramulus Taxilli 10g, bark of eucommia 10g, fruit of Chinese wolfberry 15g, corydalis tuber 10g, dried orange peel 9g, Levisticum 9g, it is clinical to be added and subtracted with disease.It is within every 7 days a course for the treatment of, continuously 2 courses for the treatment of of treatment, 2 weeks altogether, enter according to Nimodipine method Row curative effect is counted.
Results contrast
According to WOMAC scales, 2 Zhou Hou treatment groups for the treatment of are invalid 7 (21.875%), and effective 25 (78.125%) show Effect, recovery from illness are 0；Control group is invalid 13 (46.43%), effective 15 (53.57%), and effective, recovery from illness is 0.Two Group total effective rate is respectively 78.13%, 53.57%.Through Chi-square Test, statistically significant (χ 2=0.01 ＜ 0.05), explanation Treatment group's curative effect is better than control group.Treatment group to the night pain of patient, stand and walk when pain symptom, seat stands up, most Big walking distance/stair activity, the viability such as squat down have certain improvement.
In sum, pharmaceutical composition of the invention has good therapeutic effect for knee osteoarthritis, improves trouble The adventure in daily life of person.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in essence of the invention Within god and principle, any modification, equivalent substitution and improvements done etc. should be included within the scope of protection of the invention.

Claims (11)

1. a kind of pharmaceutical composition, the extract comprising following plant materials is used as active component：
The weight portion of 20 weight portion of the raw Radix Astragali -30, the weight portion of 9 weight portion of Poria cocos -12, the weight portion of 6 weight portion of rhizoma atractylodis macrocephalae -9, honey-fried licorice root The weight portion of 3 weight portion -6, the weight portion of 6 weight portion of Ligusticum wallichii -10, the weight portion of 6 weight portion of Radix Angelicae Sinensis -9, the weight of 10 weight portion of stir-baked RADIX PAEONIAE ALBA -20 Amount part, the weight portion of 10 weight portion of dogwood fruit-12 (and/or the weight portion of 9 weight portion of the root of bidentate achyranthes-15), the weight portion of optional Ramulus Taxilli 9- 12 weight portions, the weight portion of 10 weight portion of the bark of eucommia -15, the weight portion of 10 weight portion of the fruit of Chinese wolfberry -15 and the weight portion of 6 weight portion of levisticum -9.
2. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight of 10 weight portion of fructus alpiniae oxyphyllae -15 Part or the weight portion of 10 weight portion of Semen Cuscutae -15 or the weight portion of 10 weight portion of teasel root -15.
3. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight of 10 weight portion of Semen Coicis Semen Coicis -20 Amount part or the weight portion of fructus amomi 6.
4. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight portion of the coptis 3 or the weight of caulis bambusae in taenian 6 Amount part or the weight portion of 10 weight portion of Semen Coicis Semen Coicis -30.
5. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight portion of 9 weight portion of Chinese yam -12 Or the weight portion of 9 weight portion of Radix Codonopsis -12 or the weight portion of 6 weight portion of radix pseudostellariae -12.
6. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight of 10 weight portion of radix glehniae -15 Part and the weight portion of 10 weight portion of the tuber of dwarf lilyturf -20, or the weight portion of 10 weight portion of the stem of noble dendrobium -20, and/or dried rhizome of rehmannia 10-15g and/or radix scrophulariae 10- 15g。
7. pharmaceutical composition as claimed in claim 1, the plant material further include the weight portion of 6 weight portion of golden cypress -9 and The weight portion of 6 weight portion of rhizoma atractylodis -15, the weight portion of 10 weight portion of Huo Bi Collettiis -15, and/or rhizoma alismatis 10-12g and/or Herba Lycopi 10-12g.
8. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight of 10 weight portion of the root of Chinese clematis -15 Part or the weight portion of 9 weight portion of pawpaw -12 or the weight portion of 9 weight portion of lycopodium calvatum -15 or the weight portion of 9 weight portion -12 that plays both sides of the street.
9. pharmaceutical composition as claimed in claim 1, the plant material further includes the weight portion of 15 weight portion of the red sage root -20 Or the weight portion of 15 weight portion of reticulate millettia -20 or the weight portion of 3 weight portion of pseudo-ginseng -6, the weight portion of corydalis tuber 10, the weight of 6 weight portion of rhizoma cyperi -9 Part.
10. pharmaceutical composition as claimed in claim 1, the plant material further includes vine of multiflower knotweed 10-15g or stir-baked SEMEN ZIZIPHI SPINOSAE 10-15g or polygala 10-15g.
11. methods for preparing pharmaceutical composition as described in any one of claim 1 to 10 claim, the weight portion is Gram, after the plant material is mixed by above-mentioned weight portion, according to every pair the 20% of medicine 300ml to 500ml amount of liquid medicine+amount of liquid medicine As water consumption calculation amount of water is damaged, liquid is prepared using boiling machine；Or
The single herbal concentrate-granule of the plant material is taken, is mixed according to the weight any one of claim 1 to 10, The weight portion for gram, mixture obtained by the water dissolves with temperature at 92 degrees Celsius to 100 degrees Celsius.
CN201710292890.1A 2017-04-28 2017-04-28 Treat pharmaceutical composition of knee osteoarthritis and preparation method thereof Pending CN106913711A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755563A (en) * 2019-11-15 2020-02-07 汕头市中医医院 Traditional Chinese medicine composition for improving knee joint function and application thereof
CN111093398A (en) * 2017-09-14 2020-05-01 韩国韩医学研究院 Composition for preventing, improving or treating osteoarthritis containing Alpinia oxyphylla extract as active ingredient
CN112755137A (en) * 2021-03-18 2021-05-07 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) Traditional Chinese medicine composition for treating mild and moderate knee osteoarthritis and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101249220A (en) * 2008-04-08 2008-08-27 孙玉湘 Oral capsule for curing cervicobrachia, lumbodynia and leg pain and method of preparing the same
CN102973820A (en) * 2011-09-07 2013-03-20 魏加珍 Granules of Chinese patent drug for treating rheumatic and rheumatoid arthritis
CN103301402A (en) * 2013-06-04 2013-09-18 付玲玲 Traditional Chinese medicine preparation for treating orthopedic diseases and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101249220A (en) * 2008-04-08 2008-08-27 孙玉湘 Oral capsule for curing cervicobrachia, lumbodynia and leg pain and method of preparing the same
CN102973820A (en) * 2011-09-07 2013-03-20 魏加珍 Granules of Chinese patent drug for treating rheumatic and rheumatoid arthritis
CN103301402A (en) * 2013-06-04 2013-09-18 付玲玲 Traditional Chinese medicine preparation for treating orthopedic diseases and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
W. ZHANG, S. WANG, R. ZHANG, Y. ZHANG, X.LI, Y.LIN, X. WEI: "Evidence of Chinese herbal medicine", 《BMJ OPEN》 *
桑志成、王海雄: "传承胡荫奇教授病症结合思路治疗膝重度骨关节炎", 《世界中医药》 *
王海雄、桑志成、温建民、闫立、孙永生、胡海威: "补肾健脾方内服治疗膝骨关节炎的随机对照研究", 《世界中医药》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111093398A (en) * 2017-09-14 2020-05-01 韩国韩医学研究院 Composition for preventing, improving or treating osteoarthritis containing Alpinia oxyphylla extract as active ingredient
CN110755563A (en) * 2019-11-15 2020-02-07 汕头市中医医院 Traditional Chinese medicine composition for improving knee joint function and application thereof
CN110755563B (en) * 2019-11-15 2021-11-23 汕头市中医医院 Traditional Chinese medicine composition for improving knee joint function and application thereof
CN112755137A (en) * 2021-03-18 2021-05-07 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) Traditional Chinese medicine composition for treating mild and moderate knee osteoarthritis and application thereof

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