CN106902232A - It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof - Google Patents

It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof Download PDF

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Publication number
CN106902232A
CN106902232A CN201710090823.1A CN201710090823A CN106902232A CN 106902232 A CN106902232 A CN 106902232A CN 201710090823 A CN201710090823 A CN 201710090823A CN 106902232 A CN106902232 A CN 106902232A
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chinese
radix
medicine composition
chronic bronchitis
chinese medicine
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夏瑜
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Chengdu Fuhaosi Biotechnology Co Ltd
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Chengdu Fuhaosi Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed

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Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to understanding mechanism according to Chinese traditional treatment chronic bronchitis and a kind of Chinese medicine composition that can effectively treat chronic bronchitis for providing, each component and its mass parts ratio of the Chinese medicine composition are as follows:90~380g of the Radix Astragali, 150~280g of Semen Cuscutae, 100~280g of RADIX POLYGONI MULTIFLORI PREPARATA, 80~180g of the bighead atractylodes rhizome, 30~100g of Chinese gall, 60~180g of Radix Codonopsis, 60~120g of Radix Angelicae Sinensis, 150~280g of Poria cocos, windproof 50~120g, 60~180g of asparagus fern;The medicine that the present invention is provided is a Chinese prescription treated both principal and secondary aspect of disease.

Description

It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of Chinese traditional medicine composition that can effectively treat chronic bronchitis The field of thing, the Chinese medicine composition for particularly being used for chronic bronchitis patient and preparation method thereof.
Background technology
Shown according to document:Chronic bronchitis is the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucous membrane and surrounding tissue. Clinic is to cough, expectoration is cardinal symptom, and annual morbidity continues 3 months, continuous 2 years or more than 2 years.Need further to exclude tool There are the other diseases of cough, expectoration, wheezing symptoms(Such as pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, heart disease, cardiac insufficiency, bronchus The illness such as expansion, bronchial astehma, chronic nasopharyngitis, esophageal reflux syndrome).
Clinical manifestation:
Slow onset, the course of disease is long, repeatedly acute attack and aggravation.Cardinal symptom is cough, expectoration, or with panting.It is anxious Property aggravate mean cough, expectoration, pant etc. that symptom is aggravated suddenly.The main cause of acute exacerbation is respiratory tract infection, pathogen Can be virus, bacterium, mycoplasma and Chlamydia etc..
1. cough
Based on general daystart cough, there are paroxysmal cough or expectoration during sleep.
2. expectoration
Generally white mucus and slurries spumescence, occasionally can be with blood.Early morning expectoration is more, after getting up or position change can stimulate row Phlegm.
3. pant or out of breath
Pant obvious person frequently referred to AB, may partly close with bronchial astehma.If can be showed during with pulmonary emphysema For out of breath after work or activity.
Many absence of signs in early days.Acute attack stage can hear dry, moist rales at back or double bases of lung, can be reduced after cough Or disappear.Such as merge asthma audible and extensive wheezing sound and with the extension of expiration phase.
So, it is people in the art with regard to how to find a kind of Chinese medicine composition that can effectively treat chronic bronchitis Member's problem urgently to be resolved.
The content of the invention
With continuing to develop for China's traditional Chinese medicine, in treatment chronic bronchitis, during people gradually appreciate Cure the advantage for treating chronic bronchitis, and the advantage such as good effect, instant effect, toxic and side effect be small over the course for the treatment of, for existing There is the present situation of western medical treatment chronic bronchitis, it is to provide one kind can effectively treat chronic bronchitis that the purpose of the present invention is Chinese medicine composition, to solve chronic bronchitis patient restorative problem early.The medicine is to be with common Chinese medicine Raw material, by selecting rational medicine and mass parts ratio, can effectively treat above-mentioned chronic bronchitis.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is:There is provided one kind can effectively treat chronic Chinese medicine composition of bronchitis and preparation method thereof, it is characterised in that each component and its quality of the Chinese medicine composition Part is than as follows:
90~380g of the Radix Astragali, 150~280g of Semen Cuscutae, 100~280g of RADIX POLYGONI MULTIFLORI PREPARATA, 80~180g of the bighead atractylodes rhizome, 30~100g of Chinese gall, 60~180g of Radix Codonopsis, 60~120g of Radix Angelicae Sinensis, 150~280g of Poria cocos, windproof 50~120g, 60~180g of asparagus fern.
It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof, it is characterised in that in described Each component and its mass parts of drug composition are than as follows:
100~330g of the Radix Astragali, 170~250g of Semen Cuscutae, 115~250g of RADIX POLYGONI MULTIFLORI PREPARATA, 90~150g of the bighead atractylodes rhizome, 40~90g of Chinese gall, 70~150g of Radix Codonopsis, 70~105g of Radix Angelicae Sinensis, 170~250g of Poria cocos, windproof 60~105g, 70~150g of asparagus fern.
It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof, it is characterised in that it is described " most Each component and its mass parts of the Chinese medicine composition of good scheme " are than as follows:
Radix Astragali 280g, Semen Cuscutae 220g, RADIX POLYGONI MULTIFLORI PREPARATA 220g, bighead atractylodes rhizome 130g, Chinese gall 80g, Radix Codonopsis 130g, Radix Angelicae Sinensis 95g, Poria cocos 220g, windproof 95g, asparagus fern 130g.
It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof, it is characterised in that the side Method comprises the following steps to be prepared from:
A. 1. water purification will be added to decoct in above-mentioned raw materials Chinese medicine secondary, 90min is decocted every time, collect distilled water 2000ml(In the least Rise);2. collecting decoction, filtering, filtrate centrifugation, take supernatant concentration to the medicinal extract that relative density at 80 DEG C is 1.15~1.25 It is stand-by;
B. the method that Chinese medicine capsules are prepared according to tradition, will add appropriate conventional auxiliary material in the above-mentioned medicinal extract for preparing, Then it is prepared into capsule(The sealed rear total length of its capsule is 23.3mm, medicinal powder capacity 0.4~0.5g/), sealed packaging is Can.
It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof, it is characterised in that the clothes It is with method:The capsule medicine that will be prepared is serviced once sooner or later with twice a day taking, and dosage 2g/time, warm water Send down(The administration of point age size, 1 years old 0.4g/time;2 years old to 3 years old 0.8g/time;4 years old to 7 years old 1.2g/time;8 years old to 14 years old 1.6/ time;Adult 2g/ times).It is within 10 days a course for the treatment of, after 1~3 course for the treatment of of medication, symptom disappears, and disease obtains recovery from illness.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component:
The Radix Astragali, nature and flavor:Sweet, tepor, the effect of with invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating the deficiency of vital energy Weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, Flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes;
Semen Cuscutae, nature and flavor:It is Xin Gan, flat, with tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity, solid tire stopping leak the effect of, for treating waist and knee acid Bitterly, seminal emission, impotence, premature ejaculation, infertility, quench one's thirst, stranguria with turbid discharge, the enuresis, blurred vision tinnitus, fetal irritability, miscarriage, the disease such as diarrhea;
RADIX POLYGONI MULTIFLORI PREPARATA, nature and flavor:Bitter, sweet, puckery, slightly warm in nature, with nourishing the blood and yin, relax bowel, preventing malaria, wind-dispelling, removing toxic substances the effect of, use In treatment deficiency of blood Light-headedness, palpitaition, insomnia, the soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin, poliosis, tinnitus, seminal emission, dry constipation of intestines, The diseases such as chronic malaria body void, rubella itch, sore carbuncle, scrofula, hemorrhoid;
The bighead atractylodes rhizome, nature and flavor:It is bitter, sweet, warm in nature, with strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of, for treating temper The few abdominal distension of weakness, spiritlessness and weakness, deficiency of food, thin big loose stool, fluid retention stagnating in the interior, difficult urination, oedema, phlegmatic vertigo, warm numbness are ached, gas The diseases such as empty spontaneous perspiration, fetal irritability;
Chinese gall, nature and flavor:It is sour, puckery, cold, with fall fire of astringing the lung, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic sore the effect of, be used for Treatment chronic cough of deficiency lung, lung feverish cough, protracted dysentery and diarrhea, night sweat, quench one's thirst, hemorrhoid blood of having blood in stool, traumatism and bleeding, carbuncle sore tumefacting virus, skin moisture fester;
Radix Codonopsis, nature and flavor:It is sweet, mild-natured, the effect of with strengthening the spleen and tonifying the lung, nourishing generate fluid, for treating weakness of the spleen and the stomach, deficiency of food just Half congealed, limbs fatigue, the deficiency syndrome of the lung are breathed with cough, shortness of breath spontaneous perspiration, gas micro- two lose;
Radix Angelicae Sinensis, nature and flavor:It is sweet, pungent, bitter, warm in nature, with enriching blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation the effect of, for treating The all cards of the deficiency of blood, irregular menstruation, Amenorrhea, dysmenorrhoea, Disorder lumps in the abdomen knot are poly-, uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestines are dry and shit is difficult, red Weight, ulcer sores, injury from falling down after dysentery;
Poria cocos, nature and flavor:It is sweet, light, flat, the effect of with eliminating dampness and diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative, for treat difficult urination, Oedema turgor, phlegm and retained fluid cough inverse, vomiting, spleen eating less, diarrhea, palpitation and restlessness, insomnia forgetfulness, seminal emission gonorrhoea;
It is windproof, nature and flavor:Taste is pungent, sweet, slightly warm in nature, with the wet analgesic that expels pathogenic wind from the body surface, wins, only convulsion is jerked surely the effect of, it is outer for treating The illnesss such as sense table card, rubella itch, arthralgia pain due to rheumatism, lockjaw;
Asparagus fern, nature and flavor:It is sweet, bitter, cold, the effect of with nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire, for treat dryness of the lung dry cough, cough due to consumptive disease, Injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines, diphtheria, internal heat anticance, clear gesture is reduced phlegm, nourshing Yin and drynsessmoistening prescription.
Medicine of the present invention is the principle based on Chinese traditional treatment chronic bronchitis, from the pathology machine according to chronic bronchitis System and pharmacological action are thought:With regard to chronic bronchitis, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, to upper Stating disease has good therapeutic effect.
Specific embodiment
A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned chronic bronchitis, using the formula system Standby medicine effect is good, instant effect, is a Chinese prescription treated both principal and secondary aspect of disease, and is particularly suitable for Clinical practice.With reference to this hair Bright specific embodiment is described in further detail:
Embodiment 1:
A kind of Chinese medicine composition that can effectively treat chronic bronchitis, it is characterised in that each group of the Chinese medicine composition Divide and its mass parts are than as follows:
Radix Astragali 280g, Semen Cuscutae 220g, RADIX POLYGONI MULTIFLORI PREPARATA 220g, bighead atractylodes rhizome 130g, Chinese gall 80g, Radix Codonopsis 130g, Radix Angelicae Sinensis 95g, Poria cocos 220g, windproof 95g, asparagus fern 130g.
Embodiment 2:
A kind of Chinese medicine composition that can effectively treat chronic bronchitis, it is characterised in that each group of the Chinese medicine composition Divide and its mass parts are than as follows:
Radix Astragali 330g, Semen Cuscutae 250g, RADIX POLYGONI MULTIFLORI PREPARATA 250g, bighead atractylodes rhizome 150g, Chinese gall 90g, Radix Codonopsis 150g, Radix Angelicae Sinensis 105g, Poria cocos 250g, windproof 105g, asparagus fern 150g.
Embodiment 3:
A kind of Chinese medicine composition that can effectively treat chronic bronchitis, it is characterised in that each group of the Chinese medicine composition Divide and its mass parts are than as follows:
Radix Astragali 380g, Semen Cuscutae 280g, RADIX POLYGONI MULTIFLORI PREPARATA 280g, bighead atractylodes rhizome 180g, Chinese gall 100g, Radix Codonopsis 180g, Radix Angelicae Sinensis 120g, Poria cocos 280g, windproof 5120g, asparagus fern 180g.
Model case
Through clinical conditions chronic bronchitis patient totally 1880, the age is 995 of more than 16 years old, and only 885 are Less than 16 years old.1775 fully recovered in 1880 patients, effective 105, total effective rate is up to 100%.

Claims (3)

1. a kind of Chinese medicine composition that can effectively treat chronic bronchitis, it is characterised in that the Chinese medicine composition each Component and its mass parts are than as follows:
90~380g of the Radix Astragali, 150~280g of Semen Cuscutae, 100~280g of RADIX POLYGONI MULTIFLORI PREPARATA, 80~180g of the bighead atractylodes rhizome, 30~100g of Chinese gall, 60~180g of Radix Codonopsis, 60~120g of Radix Angelicae Sinensis, 150~280g of Poria cocos, windproof 50~120g, 60~180g of asparagus fern.
2. the Chinese traditional medicine composition that can effectively treat chronic bronchitis according to claim 1, it is characterised in that the Chinese medicine Each component and its mass parts of composition are than as follows:
100~330g of the Radix Astragali, 170~250g of Semen Cuscutae, 115~250g of RADIX POLYGONI MULTIFLORI PREPARATA, 90~150g of the bighead atractylodes rhizome, 40~90g of Chinese gall, 70~150g of Radix Codonopsis, 70~105g of Radix Angelicae Sinensis, 170~250g of Poria cocos, windproof 60~105g, 70~150g of asparagus fern.
3. the Chinese traditional medicine composition that can effectively treat chronic bronchitis according to claim 1 to 2, it is characterised in that described Each component and its mass parts of Chinese traditional medicine composition are than as follows:
Radix Astragali 280g, Semen Cuscutae 220g, RADIX POLYGONI MULTIFLORI PREPARATA 220g, bighead atractylodes rhizome 130g, Chinese gall 80g, Radix Codonopsis 130g, Radix Angelicae Sinensis 95g, Poria cocos 220g, windproof 95g, asparagus fern 130g.
CN201710090823.1A 2017-02-20 2017-02-20 It is a kind of effectively to treat Chinese medicine composition of chronic bronchitis and preparation method thereof Withdrawn CN106902232A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101293008A (en) * 2007-04-26 2008-10-29 浙江新光药业有限公司 Pharmaceutical composition for treating chronic bronchitis and preparation method thereof
CN104524163A (en) * 2015-01-09 2015-04-22 王深涧 Traditional Chinese medicine composition for treating chronic bronchitis with lung cancer and preparation method
KR20170013543A (en) * 2015-07-28 2017-02-07 건국대학교 글로컬산학협력단 A pharmaceutical composition comprising extract of Syneilesis palmata for prevention and treatment of inflammatory diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101293008A (en) * 2007-04-26 2008-10-29 浙江新光药业有限公司 Pharmaceutical composition for treating chronic bronchitis and preparation method thereof
CN104524163A (en) * 2015-01-09 2015-04-22 王深涧 Traditional Chinese medicine composition for treating chronic bronchitis with lung cancer and preparation method
KR20170013543A (en) * 2015-07-28 2017-02-07 건국대학교 글로컬산학협력단 A pharmaceutical composition comprising extract of Syneilesis palmata for prevention and treatment of inflammatory diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
汪海飚等: "慢性支气管炎的中医证-治相应关系研究", 《中国实验方剂学杂志》 *

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