CN106902152A - The eye drops and its production technology of a kind of anti-long visual fatigue - Google Patents

The eye drops and its production technology of a kind of anti-long visual fatigue Download PDF

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CN106902152A
CN106902152A CN201710129032.5A CN201710129032A CN106902152A CN 106902152 A CN106902152 A CN 106902152A CN 201710129032 A CN201710129032 A CN 201710129032A CN 106902152 A CN106902152 A CN 106902152A
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parts
water
solution
eye drops
injection
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彭跃芹
王海红
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SHUANGKE PHARMACEUTICAL INDUSTRY Co Ltd ANHUI PROV
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SHUANGKE PHARMACEUTICAL INDUSTRY Co Ltd ANHUI PROV
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of eye drops and its production technology for resisting long visual fatigue, drawn gauge by 20,000, the eye drops is made up of the raw material of following contents：Flos Lonicerae extractive solution 1680ml, butterflybush flower, chrysanthemum indicum and peppermint distillate 67.2kg, pearl 80g, hydrochloric acid 240ml, NaOH 104g, sodium chloride 1440g, methyl hydroxybenzoate 48g, Nipasol 16g, osmotic pressure regulation solution 1010ml, water for injection 160L；The osmotic pressure regulation solution is made from the following raw materials in parts by weight：10 12 parts of ethanol, 67 parts of glycine, 1 1.5 parts of urea, 1.7 1.9 parts of carboxymethyl chitosan, 0.6 0.7 parts of sodium acid carbonate, 2.5 3 parts of trypsase, 0.4 0.5 parts of acetic acid, 0.2 0.3 parts of sodium dihydrogen phosphate, 10 12 parts of bata-carotene, 45 50 parts of water.The anti-long raw materials used drug effect of visual fatigue eye drops that the present invention is provided does not stimulate gently, with improving eyesight, dispelling wind and heat from the body, clearing heat and detoxicating the effect of, for treating chronic catarrhal conjuntivitis, effect is obvious, the activity with treatment conjunctivitis very well, be suitable to it is popular use, with good potential applicability in clinical practice.

Description

The eye drops and its production technology of a kind of anti-long visual fatigue
Technical field
The invention belongs to medicament production technical field, it is related to a kind of eye drops, specifically a kind of eye drip of anti-long visual fatigue Liquid and its production technology.
Background technology
At present, the method for alleviating kopiopia has a lot, the main time of having a rest for including increase eye, replenishing vitamins and Use the mode of eye drops.For slight kopiopia, the mode of the time of having a rest and replenishing vitamins that increase eye can have Effect alleviates eye strain, but, for the crowd for being chronically at kopiopia state, then need to be tired to eye by means of the effect of eye drops Labor is alleviated.Eye drops species in the market is various, and main component is generally sodium hyaluronate, taurine and vitamin B6 Deng can effective malaise symptoms such as relieving eye strain.
With people's habits and customs, the change of working environment, the incidence of disease more and more higher of conjunctivitis.Traditional Chinese medicine is the Chinese people The treasure of race, its treatment to disease has that drug toxicity is low, residual rate is low, the property of medicine is gentle relative to Western medicine, does not limit to In local short, better efficacy more focuses on the regulation on the whole to human body, reaches the effect of radical curing of disease, therefore, it is more next More it is valued by people.
Eye conjunctivitis be people to infectiousness and epidemic eyes be rubescent, conjunctival congestion (or bleeding), secretion The acute bacterial for increasing or viral or allergic conjunctivitis general designation.Pinkeye is caused by one kind has a bacterium infection Common infectiousness illness in eye, also known as bacterial conjunctivitis.Motherland's medical science claims " acute conjunctivitis ", is commonly called as " outburst pinkeye ".This disease It is one kind of conjunctivitis illness, typically there are three types：Conjunctivitis catarrhalis aestiva, chronic catarrhal conjuntivitis and acute catarrh Membranous conjunctivitis.Modern medicine thinks, the pathogenic factor of pinkeye, due to Diplococcus pneumopniae section-Webster bacillus, popularity Flu bacillus, hemolytic golden yellow staphylococcus are directly invaded caused by infection conjunctiva.Motherland's medical science thinks, is because the heresy of wind-heat is outer Attack, in interior hot overabundance of yang person, inside and outside conjunction is evil, and wind-heat is mutually fought for visitor, above attacks in mesh suddenly into disease.Therefore, being bursting to develop more safety The need for the medicine of effective treatment pinkeye meets clinical treatment.
But, being cured the symptoms, not the disease existing eye drops more, use the effect to alleviation kopiopia obvious on time, once stop With then occurring dry and astringent not well, pain of itching the phenomenon of eyes immediately so that asthenope produces strong dependence to existing eye drops Property.
The content of the invention
It is an object of the invention to provide the eye drops and its production technology of a kind of anti-long visual fatigue.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of eye drops for resisting long visual fatigue, draws gauge by 20,000, and the eye drops is made up of the raw material of following contents：Gold Honeysuckle flower, purple sweetpotato extract solution 1680ml, butterflybush flower, chrysanthemum indicum and peppermint distillate 67.2kg, pearl 80g, hydrochloric acid 240ml, hydrogen Sodium oxide molybdena 104g, sodium chloride 1440g, methyl hydroxybenzoate 48g, Nipasol 16g, osmotic pressure regulation solution 1010ml, water for injection 160L；
The osmotic pressure regulation solution is made from the following raw materials in parts by weight：Ethanol 10-12 parts, glycine 6-7 parts, urea 1- 1.5 parts, carboxymethyl chitosan 1.7-1.9 parts, sodium acid carbonate 0.6-0.7 parts, trypsase 2.5-3 parts, acetic acid 0.4-0.5 parts, Sodium dihydrogen phosphate 0.2-0.3 parts, beta carotene 10-12 parts, water 45-50 parts；Its preparation method is：Raw material is sequentially added into glass In glass container, fully dissolve after being well mixed with 0.1 μm of filter membrane suction filtration, obtain filtrate and seal stand-by in glass container.
A kind of eye drops production technology of anti-long visual fatigue, the production technology comprises the steps：
By crushing pearl into fine powder, load beaker, add water and be tuned into pasty state, plus hydrochloric acid stirring is complete；Treat pearl powder and hydrochloric acid Reaction is finished, stratification, filtration；Filter residue is hydrolyzed with 15% hydrochloric acid solution and filtered；
Hydrolyzate is merged with acid hydrolysis solution and is placed in beaker, heating makes holding slight boiling condition, treat that acid hydrolysis solution evaporates, stop adding Heat is let cool, and pH value to neutrality is adjusted with 10% sodium hydroxide solution；Reheat after keeping micro-boiling to be evaporated to hydrolyzate, drying is standby With；
Water for injection is injected in Agitation Tank, adds sodium chloride to be stirred；
During borneol put into mortar, plus water for injection, to grind to form and add pearl powder after pasty state and add 0.9% sodium chloride simultaneously Solution, after stirring and dissolving, in addition Agitation Tank；
Butterflybush flower, chrysanthemum indicum and peppermint, plus distilled water are taken, steam distillation collects distillate；
Extracting honeysuckle, purple sweetpotato add water to cook extraction respectively, and decoction liquor filtering, filtrate merges, and concentration adds ethanol precipitation, mistake Filter, concentration, plus distilled water, sterilize standby；
By in honeysuckle, purple sweetpotato extract solution addition Agitation Tank；It is another to inhale butterflybush flower, chrysanthemum indicum, peppermint distillate vacuum In entering Agitation Tank；
Water for injection is added in stainless steel cask；When being heated to 100 DEG C, methyl hydroxybenzoate and Nipasol are added in bucket simultaneously Stirring makes whole dissolvings, and keeps the boil condition to add Agitation Tank；
12-16% osmotic pressure regulation solution regulation pH to 6.0-6.5 is added to Agitation Tank.
The preparation steps of 15% hydrochloric acid are：Hydrochloric acid 96ml is taken, plus water for injection 134ml is stirred evenly；Described 10% The preparation steps of sodium hydroxide solution are：NaOH 104g is taken, plus water for injection 1040ml stirs complete to dissolving；Institute The preparation steps for stating 0.9% sodium chloride solution are：Take sodium chloride 18.0g and inject water to 2000ml and stir to dissolving.
Beneficial effects of the present invention：The anti-long raw materials used drug effect of visual fatigue eye drops that the present invention is provided does not stimulate gently, With improving eyesight, dispelling wind and heat from the body, the effect of clearing heat and detoxicating, eye drops focuses on conditioning from the internal cause of kopiopia, and raw material is by closing Reason compatibility, while giving full play to the distinctive performance of each raw material itself and effect, the complementation between having taken into account, its medicine Effect complements each other, and not only therapeutic effect is notable and has no toxic side effect, and can solve eye drops in the prior art and cure the symptoms, not the disease, and makes Patient produces the problem of dependence；Eye drops natural no stimulation of the present invention, it is safe and reliable, for treating chronic Catarrhal conjunctiva Inflammation, effect substantially, with very well treatment conjunctivitis activity, be suitable to it is popular use, with good potential applicability in clinical practice.
Brief description of the drawings
For the ease of it will be appreciated by those skilled in the art that the present invention is further illustrated below in conjunction with the accompanying drawings.
Fig. 1 is that pearl of the present invention hydrolyzes process chart；
Fig. 2 is production technological process of the present invention.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, it is clear that described reality It is only a part of embodiment of the invention to apply example, rather than whole embodiments.Based on the embodiment in the present invention, this area is general All other embodiment that logical technical staff is obtained under the premise of creative work is not made, belongs to present invention protection Scope.
A kind of eye drops for resisting long visual fatigue, draws gauge, honeysuckle, purple sweetpotato extract solution 1680ml, close illiteracy by 20,000 Flower, chrysanthemum indicum and peppermint distillate 67.2kg, pearl 80g, hydrochloric acid 240ml, NaOH 104g, sodium chloride 1440g, oxybenzene first Ester 48g, Nipasol 16g, osmotic pressure regulation solution 1010ml, water for injection 160L；
Embodiment 1
A kind of eye drops production technology of anti-long visual fatigue, the production technology comprises the steps：
1st, by the crushing pearl of about 81g into fine powder, it is fitted into 5000ml beakers, the about 40ml that adds water is tuned into pasty state；Plus hydrochloric acid About 144ml, it is stirring while adding, stirred 10 minutes after hydrochloric acid is added completely into；Treat that pearl powder and hydrochloric acid reaction are finished, stand and divide Layer, filtration；Filter residue is hydrolyzed 24 hours for 230ml110 DEG C with 15% hydrochloric acid solution, filtration, referring to Fig. 1；
Hydrolyzate is merged with acid hydrolysis solution and is placed in the beaker of 2000ml, holding is made with 5 grades of heating of electric furnace of adjustable temperature Slight boiling condition, when acid hydrolysis solution is evaporated to 150ml ± 10ml, stops heating and lets cool, and is adjusted with 10% sodium hydroxide solution about 30ml Save pH value to neutrality；It is transferred in stainless steel disc after keeping micro-boiling to be evaporated to hydrolyzate with heating by electric cooker again, then is placed in drying box In 105 DEG C of dryings 2 hours, it is standby；
The preparation of 15% hydrochloric acid：Hydrochloric acid 96ml is taken, plus water for injection 134ml is stirred evenly；
The preparation of 10% sodium hydroxide solution：NaOH 104g is taken, plus water for injection 1040ml stirs complete to dissolving ；
2nd, the water for injection of about 70Kg is injected in Agitation Tank, sodium chloride 1422.0g is added, dog-house is closed and is stirred Mix；
3rd, in borneol being put into mortar, plus 50ml waters for injection, it is ground according to clockwise direction, fallen after grinding to form pasty state Pearl powder is added in the beaker for entering 2000ml and 0.9% sodium chloride solution 2000ml is added simultaneously, stirred 5 minutes, treated completely After dissolving, in addition Agitation Tank；Drip washing is carried out to beaker with the water for injection of 2000ml again, then washing water is added in the lump and is matched somebody with somebody In flow container；
The preparation of 0.9% sodium chloride solution：Take sodium chloride 18.0g and inject water to 2000ml and stir to dissolving；
4th, butterflybush flower, chrysanthemum indicum and peppermint, plus distilled water are taken, steam distillation collects distillate, another device storage；
Extracting honeysuckle, purple sweetpotato add water to cook extraction respectively, and decoction liquor filtering, filtrate merges, and is concentrated into 1: 1 (liquid: medicine Material) concentration, plus ethanol precipitation, filtering, concentration, plus distilled water, sterilize standby；
By in honeysuckle, purple sweetpotato extract solution addition Agitation Tank, with 2000ml waters for injection swing washing, and wash water will be swung In the lump in addition Agitation Tank；It is another that (butterflybush flower, chrysanthemum indicum, peppermint) distillate vacuum is sucked into (or being directly added into) Agitation Tank In；
5th, it is another water for injection about 10kg to be added in stainless steel cask；Begun to warm up with electromagnetic oven, temperature is heated to 100 DEG C When, weighed methyl hydroxybenzoate and Nipasol are added in bucket and stirred makes whole dissolvings, and keeps boil condition 5 minutes, Then while hot by solution addition Agitation Tank；At twice to the water for injection of each addition 5kg in bucket, drip washing is carried out to it, then By in washing water addition Agitation Tank；
Adding 12-16% osmotic pressure regulation solution to adjust pH to 6.0-6.5, then add water for injection makes to be shown on meter Numerical value is 161.60Kg~161.70Kg, and stirring opens chilled water in 20 minutes simultaneously, when water temperature show value is at (4~10 DEG C), Close stirring and start timing；Refrigeration 12 hours are stood, referring to Fig. 2；
Above-mentioned osmotic pressure regulation solution is made from the following raw materials in parts by weight：12 parts of ethanol, 6 parts of glycine, 1.5 parts of urea, 1.7 parts of carboxymethyl chitosan, 0.7 part of sodium acid carbonate, 2.5 parts of trypsase, 0.5 part of acetic acid, 0.2 part of sodium dihydrogen phosphate, β-Hu Radish element 12 parts, 45 parts of water；Its preparation method is：During raw material sequentially added into glass container, fully dissolving it is well mixed after use 0.1 μm of filter membrane suction filtration, obtains filtrate and seals stand-by in glass container；
6th, filter：Liquid is carried out sampling censorship during filtering is back to Agitation Tank and tested through 0.45 μm, 0.22 μm of millipore filter.
Embodiment 2
In the embodiment, osmotic pressure regulation solution is made from the following raw materials in parts by weight：10 parts of ethanol, 7 parts of glycine, urea 1 part, 1.9 parts of carboxymethyl chitosan, 0.6 part of sodium acid carbonate, 3 parts of trypsase, 0.4 part of acetic acid, 0.3 part of sodium dihydrogen phosphate, β- 10 parts of carrotene, 50 parts of water；Its preparation method is：During raw material sequentially added into glass container, fully dissolving it is well mixed after use 0.1 μm of filter membrane suction filtration, obtains filtrate and seals stand-by in glass container；Other steps are with embodiment 1.
Embodiment 3
A kind of eye drops for resisting long visual fatigue, draws gauge, honeysuckle, purple sweetpotato extract solution 1000ml, close illiteracy by 20,000 Flower, chrysanthemum indicum and peppermint distillate 67.2kg, pearl 80g, hydrochloric acid 240ml, NaOH 104g, sodium chloride 1440g, oxybenzene first Ester 48g, Nipasol 16g, osmotic pressure regulation solution 1010ml, water for injection 160L, cherry and blueberry extract solution 680ml；It is raw Production. art comprises the steps：
1st, by the crushing pearl of about 81g into fine powder, it is fitted into 5000ml beakers, the about 40ml that adds water is tuned into pasty state；Plus hydrochloric acid About 144ml, it is stirring while adding, stirred 10 minutes after hydrochloric acid is added completely into；Treat that pearl powder and hydrochloric acid reaction are finished, stand and divide Layer, filtration；Filter residue is hydrolyzed 24 hours for 230ml110 DEG C with 15% hydrochloric acid solution, filtration, referring to Fig. 1；
Hydrolyzate is merged with acid hydrolysis solution and is placed in the beaker of 2000ml, holding is made with 5 grades of heating of electric furnace of adjustable temperature Slight boiling condition, when acid hydrolysis solution is evaporated to 150ml ± 10ml, stops heating and lets cool, and is adjusted with 10% sodium hydroxide solution about 30ml Save pH value to neutrality；It is transferred in stainless steel disc after keeping micro-boiling to be evaporated to hydrolyzate with heating by electric cooker again, then is placed in drying box In 105 DEG C of dryings 2 hours, it is standby；
The preparation of 15% hydrochloric acid：Hydrochloric acid 96ml is taken, plus water for injection 134ml is stirred evenly；
The preparation of 10% sodium hydroxide solution：NaOH 104g is taken, plus water for injection 1040ml stirs complete to dissolving ；
2nd, the water for injection of about 70Kg is injected in Agitation Tank, sodium chloride 1422.0g is added, dog-house is closed and is stirred Mix；
3rd, in borneol being put into mortar, plus 50ml waters for injection, it is ground according to clockwise direction, fallen after grinding to form pasty state Pearl powder is added in the beaker for entering 2000ml and 0.9% sodium chloride solution 2000ml is added simultaneously, stirred 5 minutes, treated completely After dissolving, in addition Agitation Tank；Drip washing is carried out to beaker with the water for injection of 2000ml again, then washing water is added in the lump and is matched somebody with somebody In flow container；
The preparation of 0.9% sodium chloride solution：Take sodium chloride 18.0g and inject water to 2000ml and stir to dissolving；
5th, butterflybush flower, chrysanthemum indicum and peppermint, plus distilled water are taken, steam distillation collects distillate, another device storage；
Extracting honeysuckle, purple sweetpotato add water to cook extraction respectively, and decoction liquor filtering, filtrate merges, and is concentrated into 1: 1 (liquid: medicine Material) concentration, plus ethanol precipitation, filtering, concentration, plus distilled water, sterilize standby；
Cherry is beaten respectively with blueberry, it is stand-by to be centrifugally separating to obtain supernatant, concentration, plus distilled water, sterilize standby；
By in honeysuckle, purple sweetpotato extract solution addition Agitation Tank, with 2000ml waters for injection swing washing, and wash water will be swung In the lump in addition Agitation Tank；It is another that (butterflybush flower, chrysanthemum indicum, peppermint) distillate vacuum is sucked into (or being directly added into) Agitation Tank In；
5th, it is another water for injection about 10kg to be added in stainless steel cask；Begun to warm up with electromagnetic oven, temperature is heated to 100 DEG C When, weighed methyl hydroxybenzoate and Nipasol are added in bucket and stirred makes whole dissolvings, and keeps boil condition 5 minutes, Then while hot by solution addition Agitation Tank；At twice to the water for injection of each addition 5kg in bucket, drip washing is carried out to it, then By in washing water addition Agitation Tank；
Adding 14% osmotic pressure to adjust solution and adjust pH to 6.0, then add water for injection makes to show that numerical value is on meter 161.60KgKg, stirring opens chilled water in 20 minutes simultaneously, when water temperature show value is at (5 DEG C), closes stirring and starts timing；It is quiet Refrigeration 12 hours is put, referring to Fig. 2；
Above-mentioned osmotic pressure regulation solution is made from the following raw materials in parts by weight：12 parts of ethanol, 6 parts of glycine, 1.5 parts of urea, 1.7 parts of carboxymethyl chitosan, 0.7 part of sodium acid carbonate, 2.5 parts of trypsase, 0.5 part of acetic acid, 0.2 part of sodium dihydrogen phosphate, β-Hu Radish element 12 parts, 45 parts of water；Its preparation method is：During raw material sequentially added into glass container, fully dissolving it is well mixed after use 0.1 μm of filter membrane suction filtration, obtains filtrate and seals stand-by in glass container；
7th, filter：Liquid is carried out sampling censorship during filtering is back to Agitation Tank and tested through 0.45 μm, 0.22 μm of millipore filter.
Embodiment 4
A kind of eye drops for resisting long visual fatigue, draws gauge by 20,000, honeysuckle and gumbo extract solution 1000ml, butterflybush flower, Chrysanthemum indicum and peppermint distillate 67.2kg, pearl 80g, hydrochloric acid 240ml, NaOH 104g, sodium chloride 1440g, methyl hydroxybenzoate 48g, Nipasol 16g, osmotic pressure regulation solution 1010ml, water for injection 160L, cherry and blueberry extract solution 680ml；Production Technique comprises the steps：
Extracting honeysuckle, purple sweetpotato and gumbo add water to cook extraction respectively, and decoction liquor filtering, filtrate merges, and is concentrated into 1: 1 (liquid: medicinal material) concentration, plus ethanol precipitation, filtering, concentration, plus distilled water, sterilize standby；
Other steps are with embodiment 3
Present invention disclosed above preferred embodiment is only intended to help and illustrates the present invention.Preferred embodiment is not detailed All of details is described, it is only described specific embodiment that the invention is not limited yet.Obviously, according to the content of this specification, Can make many modifications and variations.This specification is chosen and specifically describes these embodiments, is to preferably explain the present invention Principle and practical application so that skilled artisan can be best understood by and utilize the present invention.The present invention is only Limited by claims and its four corner and equivalent.

Claims (3)

1. a kind of eye drops for resisting long visual fatigue, it is characterised in that drawn gauge by 20,000, the eye drops by following contents original Material is made：Honeysuckle, purple sweetpotato extract solution 1680ml, butterflybush flower, chrysanthemum indicum and peppermint distillate 67.2kg, pearl 80g, hydrochloric acid 240ml, NaOH 104g, sodium chloride 1440g, methyl hydroxybenzoate 48g, Nipasol 16g, osmotic pressure regulation solution 1010ml, Water for injection 160L；
The osmotic pressure regulation solution is made from the following raw materials in parts by weight：Ethanol 10-12 parts, glycine 6-7 parts, urea 1-1.5 Part, carboxymethyl chitosan 1.7-1.9 parts, sodium acid carbonate 0.6-0.7 parts, trypsase 2.5-3 parts, acetic acid 0.4-0.5 parts, phosphoric acid Sodium dihydrogen 0.2-0.3 parts, beta carotene 10-12 parts, water 45-50 parts；Its preparation method is：Raw material is sequentially added into glass to hold In device, fully dissolve after being well mixed with 0.1 μm of filter membrane suction filtration, obtain filtrate and seal stand-by in glass container.
2. it is a kind of resist long visual fatigue eye drops production technology, it is characterised in that the production technology comprises the steps：
By crushing pearl into fine powder, load beaker, add water and be tuned into pasty state, plus hydrochloric acid stirring is complete；Treat pearl powder and hydrochloric acid reaction Finish, stratification, filter；Filter residue is hydrolyzed with 15% hydrochloric acid solution and filtered；
Hydrolyzate is merged with acid hydrolysis solution and is placed in beaker, heating makes holding slight boiling condition, treat that acid hydrolysis solution evaporates, stopped heating and put It is cold, adjust pH value to neutrality with 10% sodium hydroxide solution；Reheat after keeping micro-boiling to be evaporated to hydrolyzate, drying for standby；
Water for injection is injected in Agitation Tank, adds sodium chloride to be stirred；
During borneol put into mortar, plus water for injection, to grind to form and add pearl powder after pasty state and add 0.9% sodium chloride molten simultaneously Liquid, after stirring and dissolving, in addition Agitation Tank；
Butterflybush flower, chrysanthemum indicum and peppermint, plus distilled water are taken, steam distillation collects distillate；
Extracting honeysuckle, purple sweetpotato add water to cook extraction respectively, and decoction liquor filtering, filtrate merges, and concentration adds ethanol precipitation, filters, Concentration, plus distilled water, sterilize standby；
By in honeysuckle, purple sweetpotato extract solution addition Agitation Tank；It is another to match somebody with somebody butterflybush flower, chrysanthemum indicum, the suction of peppermint distillate vacuum In flow container；
Water for injection is added in stainless steel cask；When being heated to 100 DEG C, methyl hydroxybenzoate and Nipasol are added in bucket and stirred Make whole dissolvings, and keep the boil condition to add Agitation Tank；
12-16% osmotic pressure regulation solution regulation pH to 6.0-6.5 is added to Agitation Tank.
3. it is according to claim 2 it is a kind of resist long visual fatigue eye drops production technology, it is characterised in that 15% salt Acid preparation steps be：Hydrochloric acid 96ml is taken, plus water for injection 134ml is stirred evenly；The preparation of 10% sodium hydroxide solution Step is：NaOH 104g is taken, plus water for injection 1040ml stirs complete to dissolving；0.9% sodium chloride solution Preparation steps be：Take sodium chloride 18.0g and inject water to 2000ml and stir to dissolving.
CN201710129032.5A 2017-03-06 2017-03-06 The eye drops and its production technology of a kind of anti-long visual fatigue Pending CN106902152A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114028329A (en) * 2021-12-24 2022-02-11 沈阳兴齐眼药股份有限公司 Eye drop preparation containing combined bacteriostat and product containing eye drop preparation
CN115590919B (en) * 2022-09-23 2024-02-13 合肥立方制药股份有限公司 Application of butterflybush flower and extract thereof in preparation of artificial tears

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Publication number Priority date Publication date Assignee Title
CN1400004A (en) * 2002-09-19 2003-03-05 安徽省双科药业有限公司 Chinese medicine preparation for curing chronic conjunctivitis

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Publication number Priority date Publication date Assignee Title
CN1400004A (en) * 2002-09-19 2003-03-05 安徽省双科药业有限公司 Chinese medicine preparation for curing chronic conjunctivitis

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朱昭亮等: "金珍滴眼液联合复方右旋糖酐70滴眼液治疗干眼症的效果分析", 《中国预防医学杂志》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114028329A (en) * 2021-12-24 2022-02-11 沈阳兴齐眼药股份有限公司 Eye drop preparation containing combined bacteriostat and product containing eye drop preparation
CN115590919B (en) * 2022-09-23 2024-02-13 合肥立方制药股份有限公司 Application of butterflybush flower and extract thereof in preparation of artificial tears

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Application publication date: 20170630