CN106890344A - A kind of gastrointestinal mucosal coloring agent and preparation method - Google Patents

A kind of gastrointestinal mucosal coloring agent and preparation method Download PDF

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CN106890344A
CN106890344A CN201710277292.7A CN201710277292A CN106890344A CN 106890344 A CN106890344 A CN 106890344A CN 201710277292 A CN201710277292 A CN 201710277292A CN 106890344 A CN106890344 A CN 106890344A
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chinese medicine
medicine extract
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倪猛
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Nanyang City Center Hospital
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Nanyang City Center Hospital
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Abstract

The invention discloses a kind of gastrointestinal mucosal coloring agent and preparation method, it is related to alimentary canal detection technique field.The gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is 0.15 0.3% 8 15 parts of 85 92 parts of the indicarminum aqueous solution and Chinese medicine extract, and the Chinese medicine extract includes the raw material of following parts by weight：8 15 parts of 20 30 parts of the banksia rose, 20 30 parts of malt, 20 30 parts of the fruit of a cubeb litsea tree, 20 30 parts of the root of three-nerved spicebush, 12 20 parts of dried orange peel, 12 20 parts of Chinese yam, 12 20 parts of sealwort, 8 15 parts of cloves, 8 15 parts of Radix Angelicae Sinensis, 8 15 parts of date and Radix Glycyrrhizae.Chinese medicine extract composition is also added with the coloring agent, the Chinese medicine extract has promoting the circulation of qi analgesia, invigorating spleen and reinforcing stomach, the effect of promoting blood circulation antibacterial, can reduce patient suffering, reduces alimentary canal spasm, is conducive to colour developing clear, also with health role to patient's stomach.

Description

A kind of gastrointestinal mucosal coloring agent and preparation method
Technical field
The present invention relates to alimentary canal detection technique field, more particularly, to a kind of gastrointestinal mucosal coloring agent and preparation side Method.
Background technology
Normal gastrointestinal tract mucous surface is smooth, and when having minute lesion, such as ulcer, canceration etc., surface will Change, but due to varying less when early stage, it is difficult to be found under common scope.Coloring agent is former using contrast Reason, after coloring agent is sprayed to mucous membrane, the smooth part in surface, indicarminum can not be deposited, and all be deposited on mucosal fold Between rill, sharp contrast is formed with salmon pink mucous membrane, under direct-view, form continuous lines, show the trickle recessed of mucous membrane Convex change and its stereochemical structure, be conducive to clinically can under early detection conventional endoscopic the lesion such as unconspicuous tumour, be Patient has found early and early treatment provides condition.In gastrocopy, decoration method can be used to by some dyestuffs by it is oral, Sprayed under gastroscope, vein or intra arterial injection dye gastric mucosa, then remake gastrocopy and observe its color-patch map as being beneficial to and examining The small stomach cancer of small gastric carcinoma and diameter less than 5mm of disconnected early carcinoma of stomach, particularly 6~10mm of diameter and the stomach cancer that is not true to type, and with Atrophic stomach intestinal gland metaplasia and benign ulcer are made to differentiate.
The reagent mainly methylene blue for clinically being used as alimentary canal dyeing at present, and to expect preferably dyeing radiography Effect, it is necessary to release alimentary canal spasm, in order to preferably smear gastrointestinal mucosa, so as to be conducive to showing tiny lesion, favorably In early diagnosis, early treatment.But alimentary canal sprinkling coloring agent is done patient pain, digestion are may result in when gastroscope is detected The adverse reactions such as road spasm, stomach enteroparalysis, intestinal tympanites, so as to increased the pain of patient, or even aggravate the state of an illness, are unfavorable for diagnosis And follow-up treatment.
Zhu Minggu etc. exists《Clinical diagnosis》Clinic of the upper disclosed acetic acid joint Indigo Carmine Staining to stomach Guo's film pathological changes diagnosis Value, acetic acid combines Indigo Carmine Staining to the diagnostic value of gastric mucosal lesion under inquiring into scope, as a result shows vinegar under scope Acid joint Indigo Carmine Staining is remarkably improved early carcinoma of stomach and intraepithelial neoplasia recall rate.China Patent Publication No. CN103768618A discloses a kind of gastrointestinal mucosal coloring agent, and it is the aqueous solution of sodium indigotindisulfonate.Stomach and intestine of the invention Road mucosa dyeing agent can be deposited in gastrointestinal tract mucous surface and anterior pituitary-adrenal cortex axis, make coloring mucomembranous surface and non-staining part shape Into distinct control.The not colored bump between anterior pituitary-adrenal cortex axis, it is easy to rinse, can iterative staining until satisfied.This glues Film coloring agent has the characteristics of not absorbed and had no side effect by gastrointestinal mucosa.But eliminate stomach without addition in the invention coloring agent The material of spasm, may influence testing result.
The content of the invention
In view of this, the purpose of the present invention is directed to the deficiencies in the prior art, there is provided a kind of gastrointestinal mucosal coloring agent, its Middle indicarminum good water solubility, small toxicity can obtain the definite morphological feature of gastrointestinal mucosal；And in being also added with the coloring agent Medicament extracting solution composition, the Chinese medicine extract has promoting the circulation of qi analgesia, invigorating spleen and reinforcing stomach, the effect of promoting blood circulation antibacterial, can reduce patient bitterly Hardship, reduces alimentary canal spasm, is conducive to colour developing clear, also with health role to patient's stomach.
To reach above-mentioned purpose, the present invention uses following technical scheme：
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the indicarminum water of 0.15-0.3% Solution 85-92 parts and Chinese medicine extract 8-15 parts, the Chinese medicine extract includes the raw material of following parts by weight：Banksia rose 20-30 Part, malt 20-30 parts, fruit of a cubeb litsea tree 20-30 parts, root of three-nerved spicebush 20-30 parts, dried orange peel 12-20 parts, Chinese yam 12-20 parts, sealwort 12-20 parts, Cloves 8-15 parts, Radix Angelicae Sinensis 8-15 parts, date 8-15 parts and Radix Glycyrrhizae 8-15 parts.
Further, the raw material of the gastrointestinal mucosal coloring agent, including following parts by weight：Mass fraction is 0.25% 10 parts of 90 parts of the indicarminum aqueous solution and Chinese medicine extract.
Further, the Chinese medicine extract includes the raw material of following parts by weight：25 parts of the banksia rose, 25 parts of malt, mountain are grey 25 parts of son, 25 parts of the root of three-nerved spicebush, 16 parts of dried orange peel, 15 parts of Chinese yam, 15 parts of sealwort, 12 parts of cloves, 12 parts of Radix Angelicae Sinensis, 12 parts of date and Radix Glycyrrhizae 11 Part.
Further, the Chinese medicine extract is prepared by following steps：
100-200 mesh is crushed to after raw material is mixed, is 60- by adding the volume fraction of 8-12 times of raw material weight after pretreatment 75% ethanol solution, then in apparatus,Soxhlet's, water-bath refluxing extraction 4-8h, filtrate decompression is condensed into relative density and is 1.0-1.2 solution, obtains Chinese medicine extract.
Further, described pretreatment is：Add the water of 1-2 times of weight to be soaked in the feed, be then placed in high pressure In tank, 100-120Mpa is boosted in 2-4min, after keeping 10-15s, rapid pressure release to normal pressure.
Further, the wetting time is 1-2h.
A kind of preparation method of gastrointestinal mucosal coloring agent, by the mass fraction for the indicarminum of 0.15-0.3% is water-soluble Liquid and Chinese medicine extract are well mixed, that is, prepare product.
The pharmacology of the Chinese medicine that the present invention is used：
The banksia rose：Pungent, hardship, temperature, returns spleen, stomach, large intestine, three burnt, gallbladder channels.Indication：Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.For chest gastral cavity Distending pain, weight after rush down dysentery, dyspepsia, do not feel like eating.Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal.For stomachache of having loose bowels.
Malt：It is sweet, put down, returns spleen, stomach.Indication：Promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling.For dyspepsia not Disappear, abdominal distention, spleen eating less, milk smoulders, swollen breasts, women weans.
The fruit of a cubeb litsea tree：Pungent, bitter, temperature.Indication：Expelling wind and clearing away cold, regulating qi-flowing for relieving pain.Root：Vomitted for stomach cold inverse, gastral cavity abdomen is cold Bitterly, cold hernia stomachache, stagnancy of cold-damp, turbid urine.Leaf：External application controls carbuncle furuncle bitterly, mastitis, worm snake bite, prevents bite by mosquitos. Son：Cold headache, indigestion, stomachache.
The root of three-nerved spicebush：It is pungent, temperature, return lung, spleen, kidney, bladder warp.Indication：Pleasant analgesic, warming kidney for dispelling cold.For chest and abdomen swelling and pain, The circulation of vital energy in the wrong direction breathes heavily urgency, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhoea.
Dried orange peel：It is bitter, pungent, temperature.Return lung, the spleen channel.Indication：Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For chest gastral cavity turgor, deficiency of food Vomit and diarrhoea, coughing with a lot of sputum.
Chinese yam：It is sweet, put down, returns spleen, lung, kidney channel.Indication：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For insufficiency of the spleen Deficiency of food, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, and emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For insufficiency of the spleen Deficiency of food, diarrhea loose stool, leukorrhea.
Sealwort：It is sweet, put down, returns spleen, lung, kidney channel.Indication：Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.It is empty for taste It is weak, fatigue and asthenia, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, Heat Diabetes.
Cloves：It is pungent, temperature, returns spleen, stomach, lung, kidney channel.Indication：Middle benefit gas drop is inverse, tonifies the kidney and support yang.For deficiency-cold in spleen and stomach, oh Inverse vomiting, deficiency of food is vomited and diarrhoea, trusted subordinate's crymodynia, impotence due to deficiency of the kidney.Eugenol and gallic acid in cloves etc. also have very strong anti- Oxidation, caryophyllus oil, eugenol in addition in cloves etc. also have very strong antibacterial action.
Radix Angelicae Sinensis：Sweet, acrid, warm, Return liver, the heart, the spleen channel.Indication：Replenishing and activating blood, menstruction regulating and pain relieving relaxes bowel.For blood Empty sallow, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sore Ulcer.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.And there is very strong antioxidation when giving back And antibacterial action.
Date：It is sweet, temperature.Indication：Invigorate the spleen and benefit qi, mental-tranquilization.For splenasthenic diarrhea, palpitaition, insomnia, night sweat, blood Platelet reduction property purpura.And date also has very strong antioxidation.
Radix Glycyrrhizae：It is sweet, put down, the thoughts of returning home, lung, spleen, stomach.Indication：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, emergency is stopped Bitterly, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle swells sore Poison, alleviates drug toxicity, strong.
The beneficial effects of the invention are as follows：
1st, the present invention discloses a kind of gastrointestinal mucosal coloring agent, wherein indicarminum good water solubility, and small toxicity can obtain alimentary canal and glue The definite morphological feature of film；And also it is added with Chinese medicine extract composition in the coloring agent, there is the Chinese medicine extract promoting the circulation of qi to ease pain, The effect of invigorating spleen and reinforcing stomach, promoting blood circulation antibacterial, can reduce patient suffering, reduce alimentary canal spasm, be conducive to colour developing clear, also to suffering from Person's stomach is with health role.
2nd, in the raw material of Chinese medicine extract of the present invention, with the banksia rose, malt, the fruit of a cubeb litsea tree and the root of three-nerved spicebush as monarch drug in a prescription, this few herbs Promoting qi circulation and relieving pain, regulating qi-flowing for strengthening spleen effect, compounding have promoting the circulation of qi analgesic effect；With dried orange peel, Chinese yam and sealwort as ministerial drug, this few taste medicine Effect with tonifying Qi qi-regulating, invigorating spleen and reinforcing stomach, can strengthen the effect of ministerial drug, moreover it is possible to invigorating spleen and reinforcing stomach；With cloves, Radix Angelicae Sinensis and date It is adjutant, tonifying spleen is invigorated blood circulation, and the active ingredient in cloves, Radix Angelicae Sinensis and date is respectively provided with very strong antioxygenic property and biocidal property in addition Energy；With Radix Glycyrrhizae to make medicine, coordinating the drug actions of a prescription, therefore the Chinese medicine extract of invention has promoting the circulation of qi analgesia, invigorating spleen and reinforcing stomach, promoting blood circulation antibacterial Effect, can reduce patient suffering, reduce alimentary canal spasm, increase detection accuracy.Additionally, due to indicarminum easily by air Oxidation, the antioxidation of Chinese medicine extract can strengthen the stability of indicarminum, increase the service life.
3rd, the present invention is first pre-processed, i.e., when Chinese medicine extract is prepared to raw material：1.5- is added in the feed 2.5 times of water wetting 1-2h of weight, are then placed in pressure pan, and 100-120Mpa is boosted in 2-4min, keep 10-15s Afterwards, rapid pressure release is to normal pressure；This pretreatment mode is boosted rapidly first, and normal pressure is then depressurized to rapidly, soaks the water of Chinese medicine Vapor is quickly become, volume increase is overflowed from Chinese medicine plant cell, by the cell wall damage of Chinese medicine, can greatly increase and carry Take rate.
4th, the present invention is extracted using the method that alcohol reflux is extracted to the active ingredient of raw material, the loss of active ingredient Small, recovery rate is high.
Specific embodiment
With reference to specific embodiment, the invention will be further described.
Embodiment 1
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.15% indicarminum aqueous solution 85 parts and 15 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：20 parts of the banksia rose, 20 parts of malt, 30 parts of the fruit of a cubeb litsea tree, 30 parts of the root of three-nerved spicebush, 12 parts of dried orange peel, 12 parts of Chinese yam, 12 parts of sealwort, 15 parts of cloves, 8 parts of Radix Angelicae Sinensis, 15 parts of date and sweet 8 parts of grass.
The Chinese medicine extract is prepared by following steps：
100 mesh are crushed to after raw material is mixed, by pretreatment：Adding 1 times of water of weight in the feed carries out wetting 2h, then It is put into pressure pan, 100Mpa is boosted in 2min, after keeping 15s, rapid pressure release to normal pressure；It is subsequently adding raw material weight 8 Volume fraction again is 60% ethanol solution, and afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 4h, filtrate decompression is condensed into Relative density is 1.0 solution, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 2
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.18% indicarminum aqueous solution 86 parts and 14 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：22 parts of the banksia rose, 22 parts of malt, 28 parts of the fruit of a cubeb litsea tree, 28 parts of the root of three-nerved spicebush, 14 parts of dried orange peel, 13 parts of Chinese yam, 13 parts of sealwort, 14 parts of cloves, 9 parts of Radix Angelicae Sinensis, 14 parts of date and sweet 9 parts of grass.
The Chinese medicine extract is prepared by following steps：
120 mesh are crushed to after raw material is mixed, by pretreatment：Adding 1.5 times of water of weight in the feed carries out wetting 1.5h, It is then placed in pressure pan, 105Mpa is boosted in 3min, after keeping 14s, rapid pressure release to normal pressure；It is subsequently adding raw material weight The volume fraction of 9 times of amount is 65% ethanol solution, afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 5h, filtrate decompression concentration It is 1.1 solution into relative density, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 3
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.2% indicarminum aqueous solution 88 parts and 12 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：24 parts of the banksia rose, 24 parts of malt, 26 parts of the fruit of a cubeb litsea tree, 26 parts of the root of three-nerved spicebush, 15 parts of dried orange peel, 14 parts of Chinese yam, 14 parts of sealwort, 13 parts of cloves, 10 parts of Radix Angelicae Sinensis, 13 parts of date and sweet 10 parts of grass.
The Chinese medicine extract is prepared by following steps：
140 mesh are crushed to after raw material is mixed, by pretreatment：Adding 2 times of water of weight in the feed carries out wetting 1h, then It is put into pressure pan, 110Mpa is boosted in 4min, after keeping 13s, rapid pressure release to normal pressure；It is subsequently adding raw material weight 10 Volume fraction again is 70% ethanol solution, and afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 6h, filtrate decompression is condensed into Relative density is 1.0 solution, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 4
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.25% indicarminum aqueous solution 90 parts and 10 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：25 parts of the banksia rose, 25 parts of malt, 25 parts of the fruit of a cubeb litsea tree, 25 parts of the root of three-nerved spicebush, 16 parts of dried orange peel, 15 parts of Chinese yam, 15 parts of sealwort, 12 parts of cloves, 12 parts of Radix Angelicae Sinensis, 12 parts of date and sweet 11 parts of grass.
The Chinese medicine extract is prepared by following steps：
150 mesh are crushed to after raw material is mixed, by pretreatment：Adding 1.5 times of water of weight in the feed carries out wetting 1.5h, It is then placed in pressure pan, 115Mpa is boosted in 3min, after keeping 12s, rapid pressure release to normal pressure；It is subsequently adding raw material weight The volume fraction of 11 times of amount is 70% ethanol solution, and afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 6h, filtrate decompression is dense Relative density is shortened into for 1.0 solution, Chinese medicine extract is obtained.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 5
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.3% indicarminum aqueous solution 91 parts and 9 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：28 parts of the banksia rose, 28 parts of malt, mountain Grey sub 24 parts, 24 parts of the root of three-nerved spicebush, 18 parts of dried orange peel, 16 parts of Chinese yam, 16 parts of sealwort, 11 parts of cloves, 13 parts of Radix Angelicae Sinensis, 11 parts of date and Radix Glycyrrhizae 12 parts.
The Chinese medicine extract is prepared by following steps：
160 mesh are crushed to after raw material is mixed, by pretreatment：Adding 1 times of water of weight in the feed carries out wetting 2h, then It is put into pressure pan, 120Mpa is boosted in 2min, after keeping 11s, rapid pressure release to normal pressure；It is subsequently adding raw material weight 12 Volume fraction again is 75% ethanol solution, and afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 7h, filtrate decompression is condensed into Relative density is 1.1 solution, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 6
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.15% indicarminum aqueous solution 92 parts and 8 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：30 parts of the banksia rose, 30 parts of malt, mountain Grey sub 22 parts, 22 parts of the root of three-nerved spicebush, 19 parts of dried orange peel, 18 parts of Chinese yam, 18 parts of sealwort, 10 parts of cloves, 14 parts of Radix Angelicae Sinensis, 10 parts of date and Radix Glycyrrhizae 13 parts.
The Chinese medicine extract is prepared by following steps：
180 mesh are crushed to after raw material is mixed, by pretreatment：Adding 1.5 times of water of weight in the feed carries out wetting 1h, so After be put into pressure pan, boost to 100Mpa in 3min, after keeping 10s, rapid pressure release to normal pressure；It is subsequently adding raw material weight 8 times of volume fraction is 60% ethanol solution, and afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 8h, filtrate decompression is condensed into Relative density is 1.2 solution, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 7
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.18% indicarminum aqueous solution 90 parts and 10 parts of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：20 parts of the banksia rose, 20 parts of malt, 20 parts of the fruit of a cubeb litsea tree, 20 parts of the root of three-nerved spicebush, 20 parts of dried orange peel, 20 parts of Chinese yam, 20 parts of sealwort, 9 parts of cloves, 15 parts of Radix Angelicae Sinensis, 9 parts of date and Radix Glycyrrhizae 14 parts.
The Chinese medicine extract is prepared by following steps：
200 mesh are crushed to after raw material is mixed, by pretreatment：Adding 2 times of water of weight in the feed carries out wetting 1.5h, so After be put into pressure pan, boost to 115Mpa in 4min, after keeping 15s, rapid pressure release to normal pressure；It is subsequently adding raw material weight 9 times of volume fraction is 65% ethanol solution, and afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 4h, filtrate decompression is condensed into Relative density is 1.0 solution, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Embodiment 8
A kind of gastrointestinal mucosal coloring agent, including following parts by weight raw material：Mass fraction is the 0.2% indicarminum aqueous solution 91 parts, 9 parts and 0.03 part citric acid of Chinese medicine extract, the Chinese medicine extract include the raw material of following parts by weight：The banksia rose 22 Part, 25 parts of malt, 25 parts of the fruit of a cubeb litsea tree, 25 parts of the root of three-nerved spicebush, 16 parts of dried orange peel, 18 parts of Chinese yam, 18 parts of sealwort, 8 parts of cloves, 10 parts of Radix Angelicae Sinensis, 15 parts of 8 parts of date and Radix Glycyrrhizae.
The Chinese medicine extract is prepared by following steps：
150 mesh are crushed to after raw material is mixed, by pretreatment：Adding 1.5 times of water of weight in the feed carries out wetting 2h, so After be put into pressure pan, boost to 120Mpa in 3min, after keeping 14s, rapid pressure release to normal pressure；It is subsequently adding raw material weight 10 times of volume fraction is 70% ethanol solution, afterwards in apparatus,Soxhlet's, water-bath refluxing extraction 5h, filtrate decompression concentration It is 1.1 solution into relative density, obtains Chinese medicine extract.
A kind of preparation method of gastrointestinal mucosal coloring agent, will the mass fraction for 0.15-0.3% indicarminum water Solution and Chinese medicine extract are well mixed, that is, prepare product.
Citric acid is added in the present invention, indicarminum oxidation can be also reduced, increases the steady of gastrointestinal mucosal coloring agent of the present invention It is qualitative.
Application example
The gastrointestinal mucosal coloring agent prepared using the present invention is diagnosed to patient
Case 1
Patient Wang, man, 52 years old, frequent upper abdomen pain was in often secret anguish and burns sample bitterly.It is many to occur in 1 hour after the meal, warp Gradually alleviate after 1~2 hour, until reappearing the above-mentioned rhythm and pace of moving things again after lower meal feed.The gastrointestinal mucosal prepared using embodiment 4 is contaminated Toner, as a result for：Cramps of gastrointestinal tract, bright reduction of patient pain and nausea can be substantially eliminated, body of stomach rear wall is relatively clearly showed that On have a ulcer surface, size about 3.6 × 2.2cm, base is low filthy tongue, and surrounding mucosa swells in nodal-like；Benign Gastric is diagnosed as to burst Ulcer.
Case 2
Patient Lee, female, 65 years old, upper abdomen dull pain, pain was prepared in rhythmicity, and meeting sour regurgitation and general saliva using embodiment 5 Gastrointestinal mucosal coloring agent, as a result for：Except cramps of gastrointestinal tract, patient pain is dry to be reduced trivial solution, and secretion is less, colour developing Radiography is clear, is diagnosed as duodenal ulcer.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common Other modifications or equivalent that technical staff is made to technical scheme, without departing from technical solution of the present invention Spirit and scope, all should cover in the middle of scope of the presently claimed invention.

Claims (7)

1. a kind of gastrointestinal mucosal coloring agent, it is characterised in that：Raw material including following parts by weight：Mass fraction is 0.15- 85-92 parts and Chinese medicine extract 8-15 parts of the 0.3% indicarminum aqueous solution, the Chinese medicine extract includes following parts by weight Raw material：Banksia rose 20-30 parts, malt 20-30 parts, fruit of a cubeb litsea tree 20-30 parts, root of three-nerved spicebush 20-30 parts, dried orange peel 12-20 parts, Chinese yam 12-20 Part, sealwort 12-20 parts, cloves 8-15 parts, Radix Angelicae Sinensis 8-15 parts, date 8-15 parts and Radix Glycyrrhizae 8-15 parts.
2. a kind of gastrointestinal mucosal coloring agent according to claim 1, it is characterised in that：Original including following parts by weight Material：Mass fraction is 0.25% 10 parts of 90 parts of the indicarminum aqueous solution and Chinese medicine extract.
3. a kind of gastrointestinal mucosal coloring agent according to claim 1, it is characterised in that：The Chinese medicine extract include with The raw material of lower parts by weight：25 parts of the banksia rose, 25 parts of malt, 25 parts of the fruit of a cubeb litsea tree, 25 parts of the root of three-nerved spicebush, 16 parts of dried orange peel, 15 parts of Chinese yam, sealwort 11 parts of 15 parts, 12 parts of cloves, 12 parts of Radix Angelicae Sinensis, 12 parts of date and Radix Glycyrrhizae.
4. a kind of gastrointestinal mucosal coloring agent according to claim 1, it is characterised in that：The Chinese medicine extract is by following It is prepared by step：
100-200 mesh is crushed to after raw material is mixed, is 60- by adding the volume fraction of 8-12 times of raw material weight after pretreatment 75% ethanol solution, then in apparatus,Soxhlet's, water-bath refluxing extraction 4-8h, filtrate decompression is condensed into relative density and is 1.0-1.2 solution, obtains Chinese medicine extract.
5. a kind of gastrointestinal mucosal coloring agent according to claim 4, it is characterised in that：The pretreatment is：In raw material The middle water for adding 1-2 times of weight is soaked, and is then placed in pressure pan, and 100-120Mpa is boosted in 2-4min, is kept After 10-15s, rapid pressure release to normal pressure.
6. a kind of gastrointestinal mucosal coloring agent according to claim 5, it is characterised in that：The wetting time is 1-2h.
7. a kind of preparation method of gastrointestinal mucosal coloring agent as claimed in claim 1, it is characterised in that：By the quality point Number is well mixed for the indicarminum aqueous solution and Chinese medicine extract of 0.15-0.3%, that is, prepare product.
CN201710277292.7A 2017-04-25 2017-04-25 A kind of gastrointestinal mucosal coloring agent and preparation method Pending CN106890344A (en)

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Application publication date: 20170627