CN107875356A

CN107875356A - A kind of Chinese medicine preparation for treating gallbladder polyps and preparation method thereof

Info

Publication number: CN107875356A
Application number: CN201711431472.2A
Authority: CN
Inventors: 谢小坚
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-12-22
Filing date: 2017-12-22
Publication date: 2018-04-06

Abstract

The invention discloses a kind of Chinese medicine preparation for treating gallbladder polyps, the Chinese medicine preparation includes：10~20 parts of selfheal, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of the membrane of a chicken's gizzard, 10~20 parts of radix bupleuri, 10~20 parts of felwort, 10~20 parts of stringy stonecrop, 10~20 parts of oriental wormwood, 10~20 parts of Canton love-pea vine, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of desmodium, 10~20 parts of rhizoma cyperi, 10~20 parts of pseudo-ginseng, 10~20 parts of corn stigma, 10~20 parts of radix scrophulariae, 10~20 parts of gynostemma pentaphylla, 10~20 parts of rhubarb, 10~20 parts of root tuber of aromatic turmeric, 10~20 parts of eclipta, 10~20 parts of honeysuckle, 10~20 parts of Fructus Aurantii, 10~20 parts of rascal, 10~20 parts of field pennycress, 10~20 parts of the red sage root, 10~20 parts of cape jasmine.Treat this sick doctor trained in Western medicine and advocate surgery excision gall-bladder or minimally invasive guarantor's gallbladder polyp enucleation more.There is complication, most of patient is reluctant to receive more.This disease for the treatment of by Chinese herbs has non-invasive, repeatability.All medicines share, gathers the work(of clearing gallbladder stagnation resolvation eliminating mass altogether.Full side's tool cholagogic invigorating the spleen, clearing heat and expelling damp, blood stasis-eliminating and stagnation-dissipating effect.

Description

A kind of Chinese medicine preparation for treating gallbladder polyps and preparation method thereof

Technical field

The present invention relates to contain the medical configuration product from plant, animal or raw mineral materials, more particularly to a kind for the treatment of Chinese medicine preparation of gallbladder polyps and preparation method thereof.

Background technology

Gallbladder polyp, i.e. gallbladder polyps, Gallbladder polypoid disease (polypoid lesion of gallbladder) is general Refer to all non-lithogenous lesion general names of the gallbladder wall to intracavitary in polypoid growth.It is extensive general with B ultrasound technology in China And Gallbladder polypoid disease recall rate more and more higher, its clinical, pathological characteristic and opportunity of operation select widely to be studied.

Clinically, typically can be according to the property of gallbladder polyps：It is classified as following several types：

(1) cholesterol polyps：The polyp of this type is the most common, but it is not real polyp but bile The crystallization of middle cholesterol is assembled the mulberries shape formed together and changed, and its diameter is mostly less than 1 centimetre.

(2) hyperplastic polyp：The polyp of this type is only second to cholesterol polyps, is more common in middle-aged women, 60% Patient can be with cholecystolithiasis.It is that to sexually revise its diameter be mostly 0.2-0.5 centimetres for a kind of hyperplasia of gall-bladder.

(3) Inflammatory polyps：The polyp of this type is formed on the basis of chronic cholecystitis or gall stone, its Diameter is mostly less than 1 centimetre.

(4) adenomatous polyp：The polyp of this type belongs to true property polyp, can merge chronic cholecystitis and gall stone The elderly is more common in, its diameter is mostly 0.2-2 centimetres.Clinically, bleeding can occur for adenomatous polyp, gangrenosum acne changes Become, some even can also develop into papillary adenocarcinoma.

(5) lymphoid polyp：The polyp of this type is more rare, there is the change of lymphadenia more, its diameter Size is mostly 0.1-0.3 centimetres.

The equal non-evident sympton of patient of gallbladder polyp 40%, its hidden scattered property is stronger, not by it has been found that only in B ultrasound physical examination When just find, and to the right shoulder and right back part radiation, often have diarrhoea, Nausea and vomiting, detest the indigestion symptoms such as oil, only a few Patient has heating, jaundice, and main physical signs are right epigastrium tenderness, more apparent, and it is different to be mainly manifested in digestive system to body effect Often, dysfunction of liver, and have 8-15% patient's canceration.

Doctor trained in Western medicine recognizes, and the classification of gallbladder polyp can be divided into tumprigenicity and Non-cancerous, and expert is through for many years from pathogenesis Detailed in-depth study, and modern biotechnology molecule theory is combined, guided from the patient body fluid analysis and observations and B ultrasound of nearly thousand Under, it has been observed that K-RAS genes, sum up the basic reason that all kinds polyp is formed finally.In normal human's courage cell It is interior that there is also a kind of K-RAS and a kind of (G-RAS) G-RAS, also known as polypeptide chain compound, under normal circumstances, both bases Because being in a kind of relative balance state, and a large amount of low.This activity for causing breath and suppression breath is in non-equilibrium state, in machine When body resistance declines, the immunocyte such as lymph C, mononuclear phagocyte C of body declines to the monitoring capacity for causing breath gene, then adds Under the conditions of the inducement of upper cholecystitis and cholesterol metabolism abnormity, change gall-bladder homeostasis (K-RAS) and cause breath gene activity to enter One step strengthens and combined in gall-bladder parietal cell after some gene segments, forms gene mutation, gall-bladder parietal cell occurs a kind of different Chang Zengsheng phenomenons, and to the prominent neoplasm of gall-bladder Intracavity, referred to as gallbladder polyps forming process altogether：According to gallbladder polyps disease Feature is managed, polyp is divided into five types, cholesterol accounts for 50%, and gall-bladder inflammatory accounts for 20%, adenomatous to account for 10%, adenomyoma Property accounts for 8%, and Combination polyp accounts for 17%.

TCM knowledge, the traditional Chinese medical science think the morbidity of gallbladder polyp, because (constraining, depressed, irritability) injury due to diet in disorder of emotion Exopathogen (summer-heat and damp, wind are felt in (hyperphagia fatness, sweet, thick and oily, excessive consumption of alcohol) work and rest excessively (fatigue, excessive thinking and anxiety, easiness are excessively) It is cold) etc. caused by.Liver and gall dredge rush down dereliction of duty, mechanism of qi retardance, hematogenous blockage, damp-heat accumulation, bile are secreted to arrange and stopped in unfavorable, hemostasis, with the passing of time Form abdominal mass, the disease of accumulation.Simulataneous insufficiency and excessive.During treatment, sample is preferably made a clear distinction, distinguishes actual situation.

The symptom of most of gallbladder polyps is similar to chronic cholecystitis, is mainly shown as that upper right abdomen is slightly uncomfortable, with knot Cholecystalgia is may occur in which during stone, but also there are a considerable amount of patients and asymptomatic, is simply just found when doing health examination.One As think, gallbladder polyps are the risk factors of gallbladder cancer, also there is many reports on gallbladder polyps canceration both at home and abroad in the last few years Road, especially when with calculus, canceration probability can significantly improve.

Gallbladder polypoid disease (polypoid lesion of gallbladder PLG) refers to gallbladder wall and is in intracavitary All non-lithogenous lesion general names of polypoid growth.With widely available, the Gallbladder polypoid disease recall rate of B ultrasound technology More and more higher, its symptom is similar to chronic cholecystitis, is mainly shown as that upper right abdomen is slightly uncomfortable, postprandial to aggravate, and minority is received Difference, Nausea and vomiting symptom.But clinically Most patients are asymptomatic, only merging biliary infection, calculus or biliary tract occurs Obstruction.Or clinical symptoms just occur after canceration.Found more in health examination.Gallbladder polyps are most commonly that adenomatous breath Meat, also there is inflammatory polyp, the latter Yi Zhi, the former is refractory.Treatment advocates that surgery excision gall-bladder or minimally invasive guarantor's gallbladder polyp are extractd Art.The former complication, and most of patient is reluctant to receive；The latter has certain condition limitation, popularizes relatively difficult；Depending on Treatment means are not taken in phase check, the risk that XiMin capsules be present, and the psychological pressure that patient brings is very big.

Traditional Chinese medicine shows without " gallbladder polyps " name of disease, but according to its symptom, sign and B ultrasound, the category traditional Chinese medical science " courage is swollen " " hypochondriac pain ", " accumulation " category.In the gallbladder being attached to the liver, with liver phase Yuan, courage is the fu-organ that contains refined juice, clear not turbid in its property, to lead to for use.The sick formation More with diet, disorder of emotion etc. because of Suo Youguan.The pungent tobacco and wine of overfeeding, the product of fatness, sweet, thick and oily, or disorder of emotion, taste, which lose, is good for, wet The life of evil sound, strongly fragrant and change heat, damp and hot retardance courage mansion, QI-blood circulation is obstructed, and qi depression to blood stasis, thermojunction does not dissipate, and leads to gallbladder polyps institute long Cause, card category dampness and heat stasis, its main pathogenic is that wet, the hot, stasis of blood mutually becomes trouble.Treatment is promoting blood circulation and removing blood stasis when with clearing heat secreting bile, Dissipating bind eliminating mass is method.This disease for the treatment of by Chinese herbs has non-invasive, repeatability, can avoid other therapies such as postoperative complication not Alternative advantage, now research achieve the effect of preferable, but the gallbladder polyps of maize sample that clinical discovery distributes easily are controlled, Bigger polyp, or repeatedly be complicated by infection and it is refractory with calculus person, it is proposed that to clinical symptoms than more serious suitable early row hand Art is treated.

The content of the invention

The technical problems to be solved by the invention are, treat this sick western medical treatment and advocate surgery excision gall-bladder or micro- more Wound protects gallbladder polyp enucleation.The former complication, and most of patient is reluctant to receive；The latter has certain condition limitation, popularization It is relatively difficult；And periodic review does not take treatment means, the risk of XiMin capsules be present, the psychological pressure that patient brings is very big. This disease for the treatment of by Chinese herbs has non-invasive, repeatability, can avoid the irreplaceable advantage of other therapies such as postoperative complication, Research achieves the effect of preferable now, but the gallbladder polyps of maize sample that clinical discovery distributes easily are controlled, bigger polyp, Or repeatedly be complicated by infection and it is refractory with calculus person, it is proposed that to clinical symptoms than more serious suitable early row operative treatment.

In order to solve the above technical problems, the present invention provides a kind of Chinese medicine preparation for treating gallbladder polyps, its described Chinese medicine system Agent can include the bulk drug of following parts by weight：10~20 parts of selfheal, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of the membrane of a chicken's gizzard, radix bupleuri 10~20 parts, 10~20 parts of felwort, 10~20 parts of stringy stonecrop, 10~20 parts of oriental wormwood, 10~20 parts of Canton love-pea vine, the bighead atractylodes rhizome 10~ 20 parts, 10~20 parts of desmodium, 10~20 parts of rhizoma cyperi, 10~20 parts of pseudo-ginseng, 10~20 parts of corn stigma, 10~20 parts of radix scrophulariae, twist Stock is blue 10~20 parts, 10~20 parts of rhubarb, 10~20 parts of root tuber of aromatic turmeric, 10~20 parts of eclipta, 10~20 parts of honeysuckle, Fructus Aurantii 10~20 parts, 10~20 parts of rascal, 10~20 parts of field pennycress, 10~20 parts of stringy stonecrop, 10~20 parts of the red sage root, cape jasmine 10~20 Part.

The Chinese medicine preparation of the treatment gallbladder polyps, its described Chinese medicine preparation can also include the raw material of following parts by weight Medicine：10~15 parts of selfheal, 10~15 parts of the bighead atractylodes rhizome, 10~15 parts of the membrane of a chicken's gizzard, 10~25 parts of radix bupleuri, 10~15 parts of felwort, hang down 10~15 parts of basin grass, 10~15 parts of oriental wormwood, 10~15 parts of Canton love-pea vine, 10~15 parts of the bighead atractylodes rhizome, 10~15 parts of desmodium, rhizoma cyperi 10 ~15 parts, 10~15 parts of pseudo-ginseng, 10~15 parts of corn stigma, 10~20 parts of radix scrophulariae, 10~20 parts of gynostemma pentaphylla, rhubarb 10~20 Part, 10~20 parts of root tuber of aromatic turmeric, 10~20 parts of eclipta, 10~20 parts of honeysuckle, 10~20 parts of Fructus Aurantii, 10~20 parts of rascal, Patrinia scaniosaefolia 10~20 parts of grass, 10~20 parts of stringy stonecrop, 10~20 parts of the red sage root, 10~20 parts of cape jasmine.

The Chinese medicine preparation of the treatment gallbladder polyps, its described Chinese medicine preparation can also include the raw material of following parts by weight Medicine：10~20 parts of selfheal, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of the membrane of a chicken's gizzard, 10~20 parts of radix bupleuri, 10~20 parts of felwort, hang down 10~20 parts of basin grass, 10~20 parts of oriental wormwood, 10~20 parts of Canton love-pea vine, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of desmodium, rhizoma cyperi 10 ~20 parts, 10~20 parts of pseudo-ginseng, 10~20 parts of corn stigma, 10~15 parts of radix scrophulariae, 10~15 parts of gynostemma pentaphylla, rhubarb 10~15 Part, 10~15 parts of root tuber of aromatic turmeric, 10~15 parts of eclipta, 10~15 parts of honeysuckle, 10~15 parts of Fructus Aurantii, 10~15 parts of rascal, Patrinia scaniosaefolia 10~15 parts of grass, 10~15 parts of stringy stonecrop, 10~15 parts of the red sage root, 10~15 parts of cape jasmine.

In order to solve the above technical problems, the present invention also provides a kind of Chinese medicine preparation for treating gallbladder polyps, its described Chinese medicine When the formulation of preparation is capsule, preparation process includes：

A. all raw material choppings, which are put into ethanol, extracts, as component 1；

B. by twice of stripped raw material dregs of a decoction extracting in water, as component 2；

C. above two extract solution component 1 and component is 2-in-1 simultaneously, after concentration plus dextrin reconciles and pelletized, and is filled after disinfection Enter capsule.

In the step a, all raw materials can be shredded, be soaked and be placed in lid stainless steel cask, add 70% ethanol Liquid, quality are coarse grained 0.8-1 times, are stirred, and moisten closed placement more than 1 hour, make fully to expand；By percolator The drug sample moistened after expanding is mixed pine again after paving and does to dissipate by bottom filter plate gauze bag parcel, is then contained with stainless steel spoon Powder, uniformly load percolator, fill 10-12 cm thicks, pressed with T-bar even then suitable by aforesaid operations, loading in layer Work as pressurization, medicinal powder loads 2/3 eminence that must not exceed percolator；Lid stainless steel plate fastens on medicinal powder face, opens under percolator The baiting valve in face, and a container is put, then it is slowly added into 70% ethanol；Air between medicinal powder powder to be discharged, and have Ethanol flows out about 20L or so, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out diacolation, control is oozed Speed of filtering is generally 1000g medicinal materials 2~3ml of outflow per minute, and filtrate is put into liquid container, and ethanol when emptying is fallen Enter liquid container；Percolate is merged and stood, stand for standby use, as component 1.

In the step b, the stripped raw material dregs of a decoction can be steeped in water, heating extraction 2 times, each 1-2 hours, Supernatant is removed, merges extract solution, the filtration of 100-110 mesh, then through the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 of damming, surpass 1.25 filtrate, stand for standby use, into component 2 when filtrate decompression concentration relative density is 80 DEG C.

In the step c, two kinds of extract solutions of above-mentioned steps extraction can be put into economic benefits and social benefits vacuum concentrator and be mixed, Relative density is 1.32 concentrate when first concentrating the filtrate to 80 DEG C, sets to 0~5 DEG C of deepfreezes 24 hours；Refrigeration liquid is added 0.3% filter aid diatomite, filtering, filtrate are inserted in economic benefits and social benefits vacuum concentrator, are concentrated into every 1ml medicinal extract containing 0.1g, add again Dextrin modulates grain, loads capsule after disinfection.

In order to solve the above technical problems, the present invention provides a kind of Chinese medicine preparation for treating gallbladder polyps again, its described Chinese medicine When the formulation of preparation is tablet, preparation method can also comprise the following steps：

A, take bulk drug to be put into ethanol to soak, heat extraction 2 times, is component 1；

B, dregs of a decoction extracting in water 2 times, thickening filtration, it is component 2；

C, above two component is merged, concentrated, film-making.

In the step a, bulk drug can be taken to add and soaked in the 5-10 times of ethanol measured 1-2 hours, heating extraction 2 times, Each 1-2 hours, merge extract solution, supernatant is removed after standing, then 100-120 mesh filters, then is through the molecular weight that dams 5000-10000 ultrafiltration post ultrafiltration, ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.36 medicinal extract, stand for standby use, into For component 1；In the step b, the dregs of a decoction for the bulk drug that above-mentioned ethanol extracted can be taken to add 10 times of amount water, be heated to reflux carrying Take 2 times, 1~2 hour every time, No. 2 extract solutions are merged and stood, turn into component 2.

In the step c, the merging of component 1 and component 2 can be then placed in and be concentrated under reduced pressure in tank, second is recovered under reduced pressure Alcohol, it is 0.6g crude drugs/mL to be concentrated into liquor strength, filter to filtrate relative density be 20 DEG C when 1.16；Above-mentioned filtrate is through body After product is 10L large pore resin absorption column absorption, with the deionized water or distillation water elution of 10 times of resin column volumes, then with 5 times 95% ethanol elution of resin column volume, ethanol eluate is collected, remove solvent, obtain film-making after medicinal powder is dried.

This disease category traditional Chinese medical science " courage is swollen " " hypochondriac pain ", " accumulation " category.In the gallbladder being attached to the liver, with liver phase Yuan, courage is the fu-organ that contains refined juice, It is clear not turbid in its property, to lead to for use.The sick formation is more and diet, disorder of emotion etc. are because of Suo Youguan.Treat this sick western medical treatment It is advocate surgery excision gall-bladder or minimally invasive guarantor's gallbladder polyp enucleation more.The former complication, and most of patient is reluctant to receive；Afterwards Person has certain condition limitation, popularizes relatively difficult；And periodic review does not take treatment means, the risk of XiMin capsules be present, The psychological pressure that patient brings is very big.This disease for the treatment of by Chinese herbs has non-invasive, repeatability, can avoid postoperative complication etc. The irreplaceable advantage of other therapies, now research achieve the effect of preferable, but the gall-bladder of maize sample that clinical discovery distributes Polyp is easily controlled, bigger polyp, or repeatedly be complicated by infection and it is refractory with calculus person, it is proposed that to clinical symptoms than more serious Suitable early row operative treatment.Fang Zhong, radix bupleuri, Fructus Aurantii dispersing stagnated hepatoqi, honeysuckle, felwort, rascal clearing heat-fire；Cape jasmine, root tuber of aromatic turmeric Promoting blood circulation and removing blood stasis, radix scrophulariae, selfheal softening and resolving hard mass, oriental wormwood cholagogic, simultaneously cool blood talks about blood to rheum officinale tonneau internal organs gas.All medicines share, gather altogether clear The work(of courage stagnation resolvation eliminating mass.

Embodiment

Gallbladder polyps are also known as Gallbladder polypoid disease, refer to gallbladder wall into blister cavities in a kind of lesion of limitation protuberance General name.Doctor trained in Western medicine thinks the generation of gallbladder polyps and the inflammation of gallbladder wall, many factors phase such as the change of air emptying function of gall-bladder Close.Treatment advocates operation method excision gall-bladder, and for polyp diameter >=6mm ＜ 10mm, eligible person is contemplated that row is minimally invasive Protect gallbladder polyp enucleation.And gallbladder removal has certain complication, therefore some patientss are reluctant to receive；Minimally invasive excision polyp has one Fixed condition limitation, it is difficult to popularize；And there is the risk of polyp canceration, also to patient without treatment means in passive periodic review Bring heavy psychological pressure.

Motherland's medical science thinks that gallbladder polyps belong to the categories such as " hypochondriac pain ", " courage is swollen ", " lump in the abdomen product ", its interpretation of the cause, onset and process of an illness be QI depression of the liver and gallbladder, Spleen asthenia and dampness retention, phlegm and blood stasis.Fang Zhong, radix bupleuri, Fructus Aurantii dispersing stagnated hepatoqi, honeysuckle, felwort, rascal clearing heat-fire；It is cape jasmine, strongly fragrant Golden promoting blood circulation and removing blood stasis, radix scrophulariae, selfheal softening and resolving hard mass, oriental wormwood cholagogic, rheum officinale tonneau internal organs gas and cool blood words blood.All medicines share, gather altogether The work(of clearing gallbladder stagnation resolvation eliminating mass.Full side's tool cholagogic invigorating the spleen, clearing heat and expelling damp, blood stasis-eliminating and stagnation-dissipating effect.

Selfheal is pungent, bitter, trembles with fear.Return liver, gallbladder channel.Effect, clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.1. hot eyes can be treated to swell Bitterly, dizziness of having a headache, mesh pearl nyctalgia.This product bitter cold master enters Liver Channel, is apt to purge the green with improving eyesight.With controlling liver-fire flaming, red eye, swell pain, It is medicinal mulberry leaf, chrysanthemum, cassia seed etc. can be matched somebody with somebody.Among this product is clear liver and improved vision, slightly simultaneous nourishing the liver, with Radix Angelicae Sinensis, the fruit of Chinese wolfberry, available for liver Asthenic yin, ophthalmalgia, to night more particularly；Also can match somebody with somebody rhizoma cyperi, radix glycyrrhizae use, as selfheal dissipate (《Zhang Shi doctors are logical》).2. scrofula, Goiter and tumor.This product acrid flavour energy dissipating bind, bitter cold can expel the heat-evil, often medicinal to control liver depression forming fire, the scrofula of convulsive seizure due to phlegm-fire cohesion with fritillaria, rhizoma cyperi etc. Scrofula, as selfheal soup (《Surgery is authentic》)；With goiter and tumor is controlled, then often used with kelp, radix scrophulariae etc., as selfheal cream (《Cure ancestor's gold Mirror》).3. acute mastitis swells and ache.This product can heat-clearing go irascibility, and can mass dissipating and swelling eliminating, acute mastitis swelling and pain can be controlled, often with dandelion with using (《Collected statements on the herbal foundation》).If matching somebody with somebody honeysuckle, pathopyretic ulcer can be controlled, as detoxicating pill (《Blue or green capsule is secretly handed down》).

Pseudo-ginseng, Chinese medicine name.Main product is Araliaceae in Yunnan Wenshan Prefecture, therefore named mountain of papers pseudo-ginseng, also known as literary state pseudo-ginseng Pseudo-ginseng Panax notoginseng (Burk.) F.H.Chen dry root and rhizome.Excavated, clean before autumn, the flowers are in blossom, separate Main root, branch root and rhizome, dry.Supporting root, which is practised, claims " rib ", and rhizome, which is practised, claims " clip ".Sweet, slight bitter, temperature.Channel tropism Return liver, stomach. Effect dissipate stasis of blood hemostasis, detumescence ding-tong.Cure mainly for spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, fall Flutter swelling and pain.

Strand source kind is used as medicine, and has the effect of eliminating inflammation and expelling toxin, cough-relieving apophlegmatic.For the herb of cucurbitaceous plant gynostemma pentaphylla.Taste It is bitter；Micro-sweet；It is cool in nature.Return lung；Spleen；Kidney channel.Replenish qi to invigorate the spleen, preventing phlegm from forming and stopping coughing is clearing heat and detoxicating.Effect is classified：Qi-restoratives medicine；Apophlegmatisant； Antipyretic.Cure mainly：It is physically weak weak；Nephrasthenia emission；Leukopenia；Hyperlipidemia；Virus hepatitis；Chronic gastroenteritis；Slowly Property tracheitis.Gynostemma pentaphylla is mostly important, has following Chinese medicine characteristic：Arrange in pairs or groups to boil water with ganoderma lucidum with gynostemma pentaphylla or brew up, can control Treat hypertension, high fat of blood, the disease such as hyperglycaemia, fatty liver.There is the effect of protecting liver and detoxication, lowering blood pressure and blood fat blood glucose.Gynostemma pentaphylla Main effective ingredient is gynosaponin, gynostemma pentaphylla glucoside (polysaccharide), water-soluble amino acids, flavonoids, multivitamin, micro- Secondary element, mineral matter etc.

Stringy stonecrop, Chinese medicine name.For the drying herb of crassulaceae plants stringy stonecrop.It is sweet, light, it is cool.There are removing dampness through diuresis and removing jaundice, heat-clearing The effect of removing toxic substances.It is usually used in jaundice with damp-heat pathogen, difficult urination, carbuncle swells sore.

Eclipta is also Eclipta prostrata (scientific name：Eclipta prostrata) it is the plant that composite family Eclipta prostrata belongs to.It is distributed in field side Or the ground such as all parts of the country in roadside, river bank and China's Mainland, be grown on the area of 0 meter to 1900 meters of height above sea level, at present not yet by Artificial introducing and planting.National dispersed species.It is common in field stalk, Gou Xi sides wetland.Herb is medicinal, can restrain, stop blooding, filling liver kidney it Effect.External curing plantar wart.

The membrane of a chicken's gizzard, Chinese medicine name.For Phasianidae animal family chicken Gallusgallusdomesticus Brisson drying ballast Inwall.After killing chicken, chicken gizzard is taken out, peels inwall, cleaning, drying immediately.It is sweet, put down.Returns spleen, stomach, small intestine, bladder warp.Effect is good for Stomach helps digestion, arresting seminal emission, treating stranguria fossil.Cure mainly and be used for dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, urolithiasis is puckery Bitterly, the swollen hypochondriac pain of courage.《Compendium of Materia Medica》：The wine that disappears accumulates, and is taken with bean powder ball.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：Invigorating the spleen in width, help digestion mill stomach.Control children Breast food knot is stagnant, and the big muscle of tripe is blue or green, mass in the abdomen infantile malnutrition due to digestive disturbances or intestinalparasites.

Radix bupleuri, Chinese medicine name.For《Chinese Pharmacopoeia》The herbal medicine included, medicinal part are umbelliferae bupleurum or narrow leaf bavin The dry root of Hu.Spring, the excavation of season in autumn two, remove cauline leaf and silt, dry.Radix bupleuri is conventional diaphoretic medicine.Smoke alias, mountain dish, Mushroom grass, faggot, bitter in taste, be slightly cold, Return liver, gallbladder channel.Have with inducing diaphoresis, the effect of soothing the liver rising Yang.For cold, fever, fever and chills Contact, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the prolapse of uterus, irregular menstruation.

Felwort is the root and stem of Gentianaceae herbaceos perennial Gentiana manshurica etc., main product the Northeast, spring, autumn two Ji Junke is harvested, and is preferred with the autumn person's of adopting quality.Root and rhizome is used as medicine.Bitter, cold in nature, the special heat-clearing and damp-drying drug of work(.Its purging the liver of pathogenic fire courage excess fire Effect is very strong, and can Inflammation Zhijing analgesic.Meridian distribution of property and flavor bitter, it is cold in nature.Return liver, gallbladder channel.Effect heat-clearing and damp-drying drug；Purging the liver of pathogenic fire Arresting convulsion.Jaundice with damp-heat pathogen；Urine leaching pain；Swelling of vulva the moon is overworked；Under humid tropics；The alliteration headache of liver and gall excess fire；Red eye, swell pain；Deaf ear It is swollen；Hypochondriac pain bitter taste；Pyreticosis convulsion.《Detailed outline》：Treat sore-throat, wind-heat night sweat.Phase fire is posted in liver and gall, have rush down it is of no help, therefore The gas of the beneficial liver and gall of rough gentian, just with the heat symptoms caused by an exopathgen of its energy purging the liver of pathogenic fire courage.But in big bitter Great Cold, the gas for taking the middle hair tonic that probably injures one's stomach is crossed, it is counter to help Fire-evil, also the long term usage coptis is instead from the justice of cremate.《Bencao Jingshu》：Careless rough gentian taste both answer Great Cold by big hardship, property, the medicine of pure the moon, though Real heat can be removed, the few people of stomach void blood can not gently try.Making us excessive and can't help for empty stomach bait, it is too bitter with it, under let out too far therefore.

Oriental wormwood, Latin literary fame ArtemisiacapillarisThunb. tubular flowers mesh, composite family, origanum wormwood artemisia are through the winter It is not dead, old of Chun Zeyin and give birth to, it is therefore named because of old or oriental wormwood.Then it is changed into wormwood artemisia to its seedling of summer, therefore also known as Artemisia capillaris.Folks of china shows Still have and oriental wormwood cake, the custom rolled into a ball are made with ground rice.Oriental wormwood is cooked, and to adopt tender seedling, and always medicinal is Artemisia capillaris.Therefore there is " February mattress It is old, May wormwood artemisia " saying.All herbal medicine, can flu-prevention, control heatstroke, flu, headache body weight, stomachache, vomiting, chest diaphragm is swollen Under full, vapour lock food stagnation, infantile indigestion with food retention abdominal distension, diarrhoea, menorrhalgia, uterine bleeding band, skin scratch the diseases such as overworked and oedema, its hair that radiates Boast of one's bit of contribution use, be better than peppermint especially.Make elscholtiza purchase in Yunnan, Guizhou, Sichuan San Sheng and use.Herb can carry aromatic oil, fresh stem again Leaf oil-containing 0.07-0.2%, scapus leaf oil-containing 0.15-4%, oily proportion (15 DEG C) 0.868-0.910, optical activity (20 DEG C)- 20 ° -70 °, alcohol content (in terms of vanillyl alcohol) 2-3%, amount containing phenol (in terms of thymol) is containing about 7%, in addition to for preparing essence, Also act as distiller's yeast dispensing.In addition it is good nectariferous plant again.

Canton love-pea vine, Chinese medicine name.For the drying complete stool of legume abrus cantoniensis Hance.Sweet, slight bitter, it is cool.There is removing dampness through diuresis and removing jaundice, It is clearing heat and detoxicating, the effect of dispersing the depressed liver-qi and alleviating pain.It is usually used in damp and hot yellow subcutaneous ulcer, side of body rib is not relaxed, epigastric distending pain, acute mastitis swelling and pain.Canton love-pea vine may be used also Saved in Fascinating face rainy season and carry out Baoshang and make dietotherapy.

The bighead atractylodes rhizome (zh ú), Classification system Atractylodes macrocephala.Alias small wooden raft Ji, Yu Shu, the winter bighead atractylodes rhizome, wash rice Art, poplar small wooden raft, Wu Shu, piece art, rhizoma atractylodis etc., belong to composite family, [WTBX herbaceos perennial.The nice and cool weather of happiness, is entered with rhizome Medicine, there is multinomial medicinal function.It is distributed mainly on the mountain area such as Sichuan, Yunnan, Guizhou wetland.The bighead atractylodes rhizome has strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, it is antiabortive the effect of, for spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.《Medical science Qi Yuan》Record：" dehumidifying benefit is dry, and middle QI invigorating, middle benefit gas, goes wet in taste, except stomach energy, strong taste, enters diet, antiabortive.”

Rhizoma cyperi is pungent, slight bitter, micro-sweet, puts down.Return liver, spleen, tri-jiao channel.Effect soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.It is main Control and be used for stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed, and turgor pain, menstruation is not Adjust, closed dysmenorrhea.

Corn stigma is sweet, light, mild-natured.Return bladder, liver, gallbladder channel.Function has inducing diuresis to remove edema；The effect of clearing liver cholagogic.Cure mainly Main oedema, dribbling urination, jaundice, cholecystitis, gall stone, hypertension, diabetes, alactation.《Conventional herbal medicine among the people converges Compile》：It can reduce blood pressure, inducing diuresis to remove edema.Control nosebleed, red collapse.《Traditional Chinese Medicine in Sichuan will》：Removing heat from blood, diuresis.Yellow River harnessing subcutaneous ulcer, wind-heat, Eruption, spit blood and red collapse.

Radix scrophulariae, Chinese medicine name.It is reachable more than 1 meter for Scrophulariaceae herbaceous plant.Supporting root several, spindle or carrot shape expand, It is thick reachable more than 3 centimetres.It is sweet, bitter, into, cold nature, have a clearing heat and cooling blood, nourishing Yin and falling fire, the effect of detoxicating and resolving a mass.《Do not record》： " raw sudden and violent apoplexy, typhoid fever body heat, prop up full mad heresy, before we notice it does not know people, a kind of malaria is voluminous, blood of being trembled with fear under blood lump in the abdomen, except gas in the heart, lower water, only Polydipsia, dissipate core, carbuncle swells, pain in the chest and abdomen, hard disease under neck, Ding Wuzang.”《Haigoushen》：" sudden and violent knot heat, main hot blast headache, typhoid fever can be controlled Lao Fu, dissipate knurl goitre scrofula.”《Japan hanako materia medica》：" intermittent headache heat toxin urticaria is controlled, qi-restoratives strain, the frightened agitation of the heart, bad weary hectic fever due to yin, is passed Corpse perverse trend, only forgetful, detumescence poison.”

Rhubarb, rheum officinale are being collectively referred to as the perennial plant of a variety of polygonaceae Rheums, and the title of Chinese medicine.In In the document in state area, what " rheum officinale " referred to is often todaiwo,rhizoma.In China, rheum officinale mainly make it is medicinal, but Europe and in East, their rheum officinale often refer to it is several in addition make edible Rheum kinds, stem is red, gas delicate fragrance, bitter and micro-puckery, chews it Stick to one's teeth, there is sand feeling.Autumn end cauline leaf, which is withered, or secondary spring germination is preceding excavates.Radicula is removed, scrapes off crust, valve cutting or section, rope is worn into Dry or convection drying Chinese herb rhubarb of going here and there, which has, attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.The present invention Rhubarb used refers to prepared RADIX ET RHIZOMA RHEI, and method is to take net rheum officinale block, is stewed according to wine or wine steams method (annex II D) and stewes or steam to inside and outside equal In black.Prepared RADIX ET RHIZOMA RHEI with wine is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, exerts oneself to delay, purging intense heat and detonicating. For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.There is stasis of blood haemorrhage for blood-head.

Root tuber of aromatic turmeric is pungent, bitter, trembles with fear.Return liver, the heart, lung channel.Promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, normalizing gallbladder to cure jaundice.Cure mainly use Gone mad in chest side of body shouting pain, chest impediment and cardialgia, closed dysmenorrhea, swollen breasts, pyreticosis coma, epilepsy, blood-head tells nosebleed, jaundice. 《Compendium of Materia Medica》：Vim and vigour pain in the chest and abdomen is controlled, postpartum lochiostasis affecting heart is intended to extremely, lose heart mania disease due to noxious agents produced by various parasites.《This is through meeting original》：The pungent perfume of root tuber of aromatic turmeric is not It is strong, fall after rising, enter the heart and envelope.It is bloody to control haematemesis, bleeding from five sense organs or subcutaneous tissue, spitting blood, breaks extravesated blood.Blood strangury, hematuria, married woman's passages through which vital energy circulates drive in the wrong direction, Postpartum lochiostasis affecting heart, and place epigastric pain due to blood stasis, and preferably root tuber of aromatic turmeric end plus ginger juice, boys' urine, with taking, its blood is from clear.

Honeysuckle, also known as honeysuckle (scientific name：Lonicera japonica)." honeysuckle " one is come from《Compendium of Materia Medica》, Because honeysuckle flowers are just opened as white, after switch to yellow, hence obtain one's name honeysuckle.Medicinal material honeysuckle is Caprifoliaceae woodbine Honeysuckle and congener dry flower or with the flower just opened.Honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.Its sweet cold air of property Fragrance, for clear heat with drugs of sweet flavour and cold nature without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, be used for Various febrile diseases, such as body heat, dermexanthesis, hair spot, heat toxin sore carbuncle, abscess of throat disease, equal significant effect.

Fructus Aurantii is《Chinese Pharmacopoeia》The herbal medicine included, medicinal source are rutaceae bitter orange Citrus aurantium L. and its variety drying immature fruit.July pericarp it is still green when harvest, crosscutting from middle part is two halves, is dried or low temperature Dry.Fructus Aurantii property is bitter, pungent, sour, warm, has the effect of regulating the flow of QI to ease the stomach, row stagnant dissipate-swelling, cures mainly the chest side of body stagnation of the circulation of vital energy, turgor pain, food Product is not changed, and stops in phlegm and retained fluid；The illnesss such as gastroptosis, prolapse of the anus, sub-official prolapses.

Rascal, Chinese medicine name.For rutaceae orange Citrus reticulata Blanco and its drying of variety The pericarp of young fruit or immature fruit.5~June collected from the young fruit fallen, dries, practises and claim " FTUCTUS CITRI IMMATURI "；7~August harvesting not into Ripe fruit, vertical profile eliminates flesh valve, dried, practise and claim " Sihuaqingpi " into pintongs to base portion on pericarp.It is bitter, pungent, it is warm-natured. Return liver, courage, stomach.There is soothing the liver relieving stagnant Qi, the effect of disperse accumulationsization is stagnant.For distending pain in the chest and hypochondrium, hernia pain, newborn addiction, acute mastitis, dyspepsia The stagnation of the circulation of vital energy, abdominal distention.

Field pennycress, containing villoside (villoside), morroniside (moroniside), loganin (loganin) etc..Nature and flavor：It is cool in nature, acrid flavour, hardship.Major function：It is clearing heat and detoxicating, removing blood stasis and expelling pus.For appendicitis, dysentery, intestines Inflammation, hepatitis, eye conjunctivitis, postpartum blood stasis stomachache, carbuncle swells furunculosis.Congener patrinia scabiosaefolia Fiscs P.scabiosaefolia Fisch. it is same to make field pennycress use.Enter stomach, large intestine, Liver Channel.Claim bitter beneficial dish in the localities, herbaceous plant, be grown on patana more Deng place, acrid flavour, hardship, for there is strong foot odour taste during Chinese medicine infusion, there is clearing heat and detoxicating, removing blood stasis and expelling pus and other effects.

The red sage root, Chinese medicine name.For the labiate red sage root Salvia miltiorrhiza Bge. dry root and rhizome. Spring, the excavation of season in autumn two, remove silt, dry.National most area is all distributed.It is inducing meastruation to relieve menalgia with promoting blood circulation, clearly Heart relieving restlessness, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, menstruation It is uncomfortable, dysmenorrhoea Amenorrhea, sore swell and ache curative.

Cape jasmine, scientific name：Gardenia jasminoides Ellis.Alias：Yellow Fructus Gardeniae, mountain Cape jasmine, white toad, it is Rubiaceae The fruit of plant cape jasmine.The fruit of cape jasmine is traditional Chinese medicine, the 1st batch of medicine-food two-purpose resource that the category Ministry of Public Health promulgates, has shield Liver, cholagogic, decompression, calmness, hemostasis, detumescence etc. act on.It is usually used in treating icteric hepatitis, bruise, high blood in tcm clinical practice The diseases such as pressure, diabetes.The base of glycosides containing safran, can make weld.

The specific embodiment of the invention

Specific embodiment 1：

Gather all bulk drug selfheals, the bighead atractylodes rhizome, the membrane of a chicken's gizzard, radix bupleuri, felwort, stringy stonecrop, oriental wormwood, Canton love-pea vine, in vain Art, desmodium, rhizoma cyperi, pseudo-ginseng, corn stigma, radix scrophulariae, gynostemma pentaphylla, rhubarb, root tuber of aromatic turmeric, eclipta, honeysuckle, Fructus Aurantii, rascal, Field pennycress, the red sage root, cape jasmine chopping, it is put into ethanol and extracts, as component 1.

After the dregs of a decoction 1 of stripped bulk drug are put into 10 times of amount water, heating extraction 2 times, component 2 is condensed into.

Mixing：Component 1 is 2-in-1 with component and concentrate, as raw material medicinal powder, add dextrin that granule plus honey can be made Honey refining pill can be made, add starch that tablet can be made.

Specific embodiment 2：

By the selfheal 1000g of collection, bighead atractylodes rhizome 1000g, the membrane of a chicken's gizzard 1000g, radix bupleuri 1000g, felwort 1000g, hang down basin Careless 1000g, oriental wormwood 1000g, Canton love-pea vine 1000g, bighead atractylodes rhizome 1000g, desmodium 1000g, rhizoma cyperi 1000g, pseudo-ginseng 1000g, corn Palpus 1000g, radix scrophulariae 1000g, gynostemma pentaphylla 1000g, rhubarb 1000g, root tuber of aromatic turmeric 1000g, eclipta 1000g, honeysuckle 1000g, Fructus Aurantii 1000g, rascal 1000g, field pennycress 1000g, red sage root 1000g, cape jasmine 1000g, chopping chopping, soaked and be placed in In lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, is stirred, and moistens closed place 1 hour More than, make fully to expand；The drug sample moistened after expanding is mixed again after filter plate gauze bag parcel in percolator bottom is paved It is loose to do to dissipate, powder then is contained with stainless steel spoon, uniformly loads percolator, fills 10-12 cm thicks, it is even with T-bar pressure, then by upper Operation is stated, loading in layer is appropriate to pressurize, and medicinal powder loads 2/3 eminence that must not exceed percolator；Medicinal powder covers not on face Rust steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；It is to be discharged Air between medicinal powder powder, and there is ethanol to flow out about 20L or so, baiting valve is closed, covers cylinder of filtering, dipping 24 hours, so After open baiting valve carry out diacolation, control diacolation speed be generally 1000g medicinal materials 2~3ml of outflow per minute, filtrate is put into reservoir In cylinder, and ethanol when emptying is poured into liquid container；Percolate is merged and stood, stand for standby use, as component 1.Will extraction Cross the raw material dregs of a decoction to steep in water after 24 hours, heating extraction 2 times, each 1-2 hours, remove supernatant, merge extract solution, 100- 110 mesh filter, then are concentrated under reduced pressure relative density through the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 of damming, ultrafiltrate as 80 DEG C when 1.25 filtrate, stand for standby use, into component 2.Two kinds of extract solutions that above-mentioned steps are extracted, it is put into economic benefits and social benefits vacuum concentration Mixed in device, relative density is 1.32 concentrate when first concentrating the filtrate to 80 DEG C, sets to 0~5 DEG C of deepfreezes 24 hours； Refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate is inserted in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml and contains again 0.1g medicinal extract, starch is added to prepare piece agent.

Specific embodiment 3：

By the selfheal 1200g of collection, bighead atractylodes rhizome 1100g, the membrane of a chicken's gizzard 1100g, radix bupleuri 1100g, felwort 1200g, hang down basin Careless 1100g, oriental wormwood 1200g, Canton love-pea vine 1200g, bighead atractylodes rhizome 1100g, desmodium 1100g, rhizoma cyperi 1100g, pseudo-ginseng 1200g, corn Palpus 1200g, radix scrophulariae 1200g, gynostemma pentaphylla 1100g, rhubarb 1100g, root tuber of aromatic turmeric 1200g, eclipta 1100g, honeysuckle 1100g, Fructus Aurantii 1100g, rascal 1200g, field pennycress 1200g, red sage root 1200g, cape jasmine 1200g, steep in 10 times of amount ethanol 24 hours Afterwards, heating extraction 2 times, each 1-2 hours, supernatant being removed, merges extract solution, 100-110 mesh filters, then through the molecular weight that dams For 6000-10000 ultrafiltration post ultrafiltration, ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.36 medicinal extract, heating is concentrated into Paste, stand for standby use, into component 1.The dregs of a decoction that above-mentioned ethanol extracted are added into 10 times of amount water heating and refluxing extractions 2 times, every time 1 ~2 hours, No. 2 extract solutions are merged and stood, above two extract solution are merged, as component 2；Merge the component 2 of component 1 to subtract 1.38 filtrate, reclaims ethanol when pressure concentration relative density is 70 DEG C, calls in dextrin or honey, and being bottled after ultraviolet sterilization will Two kinds of extract solutions of above-mentioned steps extraction, are put into economic benefits and social benefits vacuum concentrator and mix, first concentrate the filtrate to relative at 80 DEG C Density is 1.32 concentrate, sets to 0~5 DEG C of deepfreezes 24 hours；Refrigeration liquid is added to 0.3% filter aid diatomite, mistake Filter, filtrate are inserted in economic benefits and social benefits vacuum concentrator, are concentrated into every 1ml medicinal extract containing 0.1g, add honey to reconcile, be twisted into pill again.

Pharmacological toxicity is tested

First, skin irritation test

Acute skin irritation test report of the present invention

1st, experiment purpose：Detect Tablets to the stimulation/corrosiveness and intensity 2 of experimental animal skin, material and Method：

2.1. tested material：Title：Tablets

2.2. experimental animal：One grade big ear white race rabbit, 10, female, body weight 2.1-2.3kg；By biology department of medical college Experimental Animal Center provides；

2.3. test method：

From the healthy rabbits 10 that skin is intact, its back backbone both sides hair was cut in 24 hours before experiment, gone The left and right each about 4cm × 4cm of gross area.Take tested material 0.2ml to be applied on 2.5cm × 2.5cm two layers of gauze during experiment, apply In side skin of unhairing surface, oilpaper covering, immobilization with adhesive tape.Opposite side skin is as blank control.After closing 4 hours, remove Covering, and residual tested material is cleaned with warm water, area skin is smeared in the treatment in 1,24 and 48 hour after tested material is removed Reaction, and score.

3rd, experimental result：Experimental animal skin does not occur any erythema, red and swollen, inflammation phenomenon.

4th, brief summary：According to《Disinfection technology standard》(1999) skin wound repair standards of grading judge in, and the present invention is to dynamic Thing skin irritatin intensity belongs to nonirritant.

2nd, animal acute toxicity test is studied：

Tablets are through trial test, it is impossible to measure LD 50, therefore determine maximum dosage-feeding.Using rectal delivery, The maximum dosage-feeding on the one for measuring mouse is 22.7g/kg (in terms of medicinal powder), about intend clinical people's dosage 867.5 times (people with 60kg is counted), the maximum dosage-feeding 35.7g/kg (in terms of medicinal powder) on the one of rat, about intend clinical people's dosage 987.5 times.It is real Test the equal Continuous Observation of animal one week, its appearance sign, the state of mind, diet, drinking-water, excrement etc. are showed no obvious abnormalities.Experiment At the end of, animal health survival, increased weight.

3rd, long-term toxicity test for animals is studied：

This experiment sets the high, medium and low dosage group of medicine of the present invention and matrix control group, blank control group, using rectally Approach gives rat, and dosage is respectively 3.2,2.4 and 1.6g/kg (in terms of medicinal powder), equivalent to plan clinical patient dosage 80,60 and 40 times of [0.04g (medicinal powder)/kg], successive administration 2 months, in administration process, each administration group and matrix group is big The body weight of mouse, dietary amount, appearance sign, behavioral activity, the state of mind, hair color, fecal character are compared with blank control group, nothing Notable difference (P ＞ 0.05), the weight of animals increasing value and Main Organ Coefficients and not notable (the P ＞ of blank control group comparing difference 0.05), hematology and the indivedual indexs of blood parameters inspection result administration group and blank control group comparing difference significantly (P ＜ 0.05), but convalescence terminates rear discrepant hematology and blood parameters have recovered normal, other indexs and blank It is not notable (P ＞ 0.05) to compare difference, administration phase and convalescence histological examination high dose group animal main organs and sky White control group relatively has no notable difference, has no that slowness toxicity occurs.

Clinical test：

Materials and methods

Gallbladder polyps are liver and gall common disease, frequently-occurring disease, although the overwhelming majority is benign lesion, truly have a few portion Divide and hide early carcinoma and precancerous lesion.The present invention treats this disease 50 from clearing gallbladder stagnation resolvation eliminating mass soup is intended, and is treated with JINDAN PIAN 50 compareed, it is evident in efficacy, hereby report it is as follows：

1 data and method

1.1 clinical data.100 patients are our hospital's in May, 2012 to out-patient in 2016, diagnostic criteria reference 《Ultrasound medicine》In diagnostic criteria on Gallbladder polypoid disease, made a definite diagnosis through ultrasound diagnosis.In treatment group 50, man 26 Example, female 24；It is one 76 years old 26 years old age, average 41.4 years old；The course of disease -21 years 4 months.In control group 50, man 25, female 25 Example；It is one 75 years old 25 years old age, average 45.5 years old；The course of disease -22 years 2 months.Two groups of cases are in terms of sex, age, the course of disease without aobvious Sex differernce is write, there is comparativity (P ＞ 0.05).

1.2 treatment method.

1.2.1 treatment group.Using from clearing gallbladder stagnation resolvation eliminating mass soup is intended, form：Selfheal 12g, bighead atractylodes rhizome 11g, the membrane of a chicken's gizzard 11g, Radix bupleuri 11g, felwort 12g, stringy stonecrop 11g, oriental wormwood 12g, Canton love-pea vine 12g, bighead atractylodes rhizome 11g, desmodium 11g, rhizoma cyperi 11g, pseudo-ginseng 12g, corn stigma 12g, radix scrophulariae 12g, gynostemma pentaphylla 11g, rhubarb 12g, root tuber of aromatic turmeric 13g, eclipta 11g, honeysuckle 11g, Fructus Aurantii 11g, rascal 12g, field pennycress 12g, stringy stonecrop 12g, red sage root 12g, cape jasmine 12g, daily 1 dose of top, it is decocted in water for oral dose.(or by this hair Capsule is made in bright illustrated embodiment) withdraw other drugs during treatment, keep mood happy, the pungent tobacco and wine of fasting, delicious food are thick Greasy thing.

1.2.2 control group.Oral XIAOYAN LIDAN PIAN (Guangdong Wannianqing Pharmaceutical Co., Ltd.'s production), each 3-5 pieces, often Day 2 times.

Two groups continuously take medicine 15 days be 1 course for the treatment of, even served 2-4 individual month.Monthly check 1 B ultrasound.

1.3 criterion of therapeutical effect.With reference to the Ministry of Public Health《New Chinese medicine treats the guideline of clinical investigations of chronic cholecystitis》Intend Order.Cure：B ultrasound check polyp disappears, and clinical symptom disappearance；Effectively：Polyp is reduced, and number is reduced, but clinical symptoms have instead It is multiple；It is invalid：Size, number and the clinical symptoms of polyp improve equal unobvious.

1.4 statistical procedures methods.Statistical procedures, the comparison of total effective rate are carried out using SPSSI0.0 statistical softwares With X²Examine, P ＜ 0.05, property that there were significant differences.

2 results

Two groups of Clinical efficacy comparisons are shown in Table 1.Two groups of total effective rates compare, and treatment group's total effective rate 76%, control group always has Efficiency 62% (P ＜ 0.05), difference significance.

Curative effect compares n (%) after 1 two groups of treatments of table

Group	N	Cure	Effectively	It is invalid	Total effective rate
						Treatment group	50	21(42)	17(34)	12(24)	76%*
Control group	50	12(24)	14(28)	24(48)	52%

Note：Compared with control group, * P ＜ 0.05, difference significance.

Gall-bladder capsule polypoid lesion (polypoid lesion of gallbladder PLG) refers to gallbladder wall to intracavitary All non-lithogenous lesion general names grown in polypoid.With widely available, the Gallbladder polypoid disease detection of B ultrasound technology Rate more and more higher, its symptom is similar to chronic cholecystitis, is mainly shown as that upper right abdomen is slightly uncomfortable, postprandial to aggravate, and minority is received Difference, Nausea and vomiting symptom.But Most patients are asymptomatic on Clinical Discussion, only merging biliary infection, calculus or generation Biliary obstruction.Or clinical symptoms just occur after canceration.Found more in health examination.Gallbladder polyps are most commonly that adenoma Property polyp, also has inflammatory polyp, the latter Yi Zhi, the former is refractory.Treatment advocates that surgery excision gall-bladder or minimally invasive guarantor's gallbladder polyp are plucked Except art.The former complication, and most of patient is reluctant to receive；The latter has certain condition limitation, popularizes relatively difficult；And Periodic review does not take treatment means, the risk of XiMin capsules be present, and the psychological pressure that patient brings is very big.

This clinical Most patients of card is asymptomatic, is only merging biliary infection, calculus or biliary obstruction occurs.Or dislike Clinical symptoms just occur after change.Found more in health examination.Gallbladder polyps are most commonly that adenomatous polyp, also there is inflammation Property polyp, the latter Yi Zhi, the former is refractory.Treatment advocates surgery excision gall-bladder or minimally invasive guarantor's gallbladder polyp enucleation.The former has more Complication, most of patient are reluctant to connect；The latter has certain condition limitation, popularizes relatively difficult；And periodic review is not taken and controlled , there is the risk of XiMin capsules in treatment means, the psychological pressure that patient brings is very big.

Traditional Chinese medicine shows without " gallbladder polyps " name of disease, but according to its symptom, sign and B ultrasound, the category traditional Chinese medical science " courage is swollen " " hypochondriac pain ", " accumulation " category.In the gallbladder being attached to the liver, with liver phase Yuan, courage is the fu-organ that contains refined juice, clear not turbid in its property, to lead to for use.The sick formation More with diet, disorder of emotion etc. because of Suo Youguan.The pungent tobacco and wine of overfeeding, the product of fatness, sweet, thick and oily, or disorder of emotion, taste, which lose, is good for, wet The life of evil sound, strongly fragrant and change heat, damp and hot retardance courage mansion, QI-blood circulation is obstructed, and qi depression to blood stasis, thermojunction does not dissipate, and leads to gallbladder polyps institute long Cause, card category dampness and heat stasis, its main pathogenic is that wet, the hot, stasis of blood mutually becomes trouble.Treatment is promoting blood circulation and removing blood stasis when with clearing heat secreting bile, Dissipating bind eliminating mass is method.

Specific embodiment：Mr. Wang, male, 30 years old, first visit on May 11 in 2015.The unit organization of in August, 2014 is in certain institute's body Inspection, B ultrasound find gall stone, 0.8cm.Take traditional Chinese medicine Paishi Tang, and ultrasound diagnosis calculus disappears, and has now found that gall-bladder polyposis, Patient fears operation, it is desirable to Chinese traditional treatment.Physical condition is good, and right upper quadrant of the abdomen is slightly uncomfortable, dry throat, dark tongue quality, tongue it is thin it is white, in The heart is fine and smooth without tongue, arteries and veins.Dialectical category deficiency of both vital energy and Yin, phlegm and blood stasis.It is in harmony with supplementing qi and nourishing yin, promoting blood circulation and removing blood stasis, resolving sputum scattered plot.It is medicinal：Summer Withered grass 12g, bighead atractylodes rhizome 11g, the membrane of a chicken's gizzard 11g, radix bupleuri 11g, felwort 12g, stringy stonecrop 11g, oriental wormwood 12g, Canton love-pea vine 12g, in vain Art 11g, desmodium 11g, rhizoma cyperi 11g, pseudo-ginseng 12g, corn stigma 12g, radix scrophulariae 12g, gynostemma pentaphylla 11g, rhubarb 12g, root tuber of aromatic turmeric 13g, eclipta 11g, honeysuckle 11g, Fructus Aurantii 11g, rascal 12g, field pennycress 12g, stringy stonecrop 12g, red sage root 12g, cape jasmine 12g, 1 dose of day, 2 morning and evening sub-services of decocting.Slightly added and subtracted above abiding by and take 40 doses altogether, dry throat, right epigastric discomfort disappears, and tongue nature is light red, tongue Bao Bai, arteries and veins ease up.Physical examination B ultrasound check in 2017, polyp disappear, gall-bladder no abnormality seen.

Gallbladder polypoid disease is without special clinical manifestation, and how asymptomatic early stage is, or only some non-specific symptoms, such as Epigastric discomfort, indigestion etc., thus early diagnose it is difficult, if there is symptom, be also mainly the symptom similar to gallbladder cancer such as Right epigastric discomfort and (or) secret anguish, with the progress of lesion or when being associated with calculus, inflammation etc., courage strand such as can further occur Bitterly, the symptom such as heating, shiver with cold, jaundice, thus it is clinical easily fail to pinpoint a disease in diagnosis or mistaken diagnosis, or be only satisfied with diagnosis to cholecystolithiasis and Miss Gallbladder polypoid disease.

Gall-bladder cholesterol polyp and adenomatous polyp in sex, age of onset, whether be associated with cholecystitis Shang Wu areas Not, clinical symptoms and the cholesterol polyp of merging calculus are significantly more than adenomatous polyp.What cholesterol polyp was formed rises Because be liver cell secretion of bile function there occurs disorder, bile acid is solid constituent main in bile, accounts for 85%. When Determination of Total Bile Acids In Bile content reduces and total cholesterol concentration raises, cholesterol separates out, and promotes cholesterol polyp Formed, so its merging calculus number of cases is significantly more than adenomatous polyp in cholesterol polyp.And gall-bladder cholesterol polyp The clinical symptoms of patient are at least partly as caused by simultaneously and concurrently gall stone.

Capsule polypoid lesion is mostly cholesterol polyp, adenomyoma sample lesion and inflammatory polyp, the possibility of gallbladder cancer compared with It is small.And adenomatous polyp is a kind of precancerous lesion, mamillary, tubulose and pipe mamillary three types can be divided into.Gall-bladder is accounted for cut Except the 1.1% of sample, middle and aged women is more common in.Can single-shot or multiple, diameter 0.5cm-2.0cm, it is that gene is dashed forward Become, the result of missing, cause canceration, infiltration, hematogenous metastasis of cell etc..Once make a definite diagnosis, suitable surgery excision.Think that diameter is small Canceration does not occur in 10mm Gallbladder polypoid disease.Diameter is more than 10mm lesion, especially greater than 15mm person, pernicious Possibility is very big.For the form of lesion, lesion bears shape uniformly strong echo, single or branch-like nipple in rice-shaped or mulberry Sample essence echo is mostly benign, and swells in deep sample substance echo or irregularly substantive echo and then consider pernicious canceration Possibility is big.The possibility that the usual Multiple of quantity of lesion is benign is big, and the pernicious possibility of solitary lesion is big. It should cause enough attention in diagnosis and treatment.

Claims

1. a kind of Chinese medicine preparation for treating gallbladder polyps, it is characterised in that the Chinese medicine preparation includes the raw material of following parts by weight Medicine：10~20 parts of selfheal, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of the membrane of a chicken's gizzard, 10~20 parts of radix bupleuri, 10~20 parts of felwort, hang down 10~20 parts of basin grass, 10~20 parts of oriental wormwood, 10~20 parts of Canton love-pea vine, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of desmodium, rhizoma cyperi 10~ 20 parts, 10~20 parts of pseudo-ginseng, 10~20 parts of corn stigma, 10~20 parts of radix scrophulariae, 10~20 parts of gynostemma pentaphylla, 10~20 parts of rhubarb, 10~20 parts of root tuber of aromatic turmeric, 10~20 parts of eclipta, 10~20 parts of honeysuckle, 10~20 parts of Fructus Aurantii, 10~20 parts of rascal, field pennycress 10 ~20 parts, 10~20 parts of the red sage root, 10~20 parts of cape jasmine.

2. according to claim 1 treat gallbladder polyps Chinese medicine preparation, it is characterised in that the Chinese medicine preparation also include with The bulk drug of lower parts by weight：10~15 parts of selfheal, 10~15 parts of the bighead atractylodes rhizome, 10~15 parts of the membrane of a chicken's gizzard, 10~25 parts of radix bupleuri, rough gentian 10~15 parts of grass, 10~15 parts of stringy stonecrop, 10~15 parts of oriental wormwood, 10~15 parts of Canton love-pea vine, 10~15 parts of the bighead atractylodes rhizome, desmodium 10~ 15 parts, 10~15 parts of rhizoma cyperi, 10~15 parts of pseudo-ginseng, 10~15 parts of corn stigma, 10~20 parts of radix scrophulariae, 10~20 parts of gynostemma pentaphylla, system 10~20 parts of rheum officinale, 10~20 parts of root tuber of aromatic turmeric, 10~20 parts of eclipta, 10~20 parts of honeysuckle, 10~20 parts of Fructus Aurantii, rascal 10~ 20 parts, 10~20 parts of field pennycress, 10~20 parts of the red sage root, 10~20 parts of cape jasmine.

3. according to claim 1 treat gallbladder polyps Chinese medicine preparation, it is characterised in that the Chinese medicine preparation also include with The bulk drug of lower parts by weight：10~20 parts of selfheal, 10~20 parts of the bighead atractylodes rhizome, 10~20 parts of the membrane of a chicken's gizzard, 10~20 parts of radix bupleuri, rough gentian 10~20 parts of grass, 10~20 parts of stringy stonecrop, 10~20 parts of oriental wormwood, 10~20 parts of Canton love-pea vine, 10~20 parts of the bighead atractylodes rhizome, desmodium 10~ 20 parts, 10~20 parts of rhizoma cyperi, 10~20 parts of pseudo-ginseng, 10~20 parts of corn stigma, 10~15 parts of radix scrophulariae, 10~15 parts of gynostemma pentaphylla, system 10~15 parts of rheum officinale, 10~15 parts of root tuber of aromatic turmeric, 10~15 parts of eclipta, 10~15 parts of honeysuckle, 10~15 parts of Fructus Aurantii, rascal 10~ 15 parts, 10~15 parts of field pennycress, 10~15 parts of the red sage root, 10~15 parts of cape jasmine.

4. a kind of Chinese medicine preparation that gallbladder polyps are treated as any one of claims 1 to 3, it is characterised in that in described When the formulation of medicine preparation is capsule, preparation process includes：

C. above two extract solution component 1 and component is 2-in-1 simultaneously, after concentration plus dextrin reconciles and pelletized, and loads glue after disinfection Capsule.

5. the preparation method of the capsule of the Chinese medicine preparation of gallbladder polyps is treated according to claim 4, it is characterised in that institute State in step a, all raw materials are shredded, soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse granule 0.8-1 times, stir, moisten it is closed place more than 1 hour, make fully to expand；By percolator bottom filter plate gauze bag The drug sample moistened after expanding is mixed pine again after paving and does to dissipate by parcel, is then contained powder with stainless steel spoon, is uniformly loaded diacolation Cylinder, 10-12 cm thicks are filled, it is even with T-bar pressure, then loaded not by aforesaid operations, loading in layer, appropriate pressurization, medicinal powder 2/3 eminence of percolator must be exceeded；Lid stainless steel plate fastens on medicinal powder face, opens the baiting valve below percolator, and put one Container, then it is slowly added into 70% ethanol；Air between medicinal powder powder to be discharged, and there is ethanol to flow out about 20L or so, close Baiting valve is closed, covers cylinder of filtering, dipping 24 hours, baiting valve is then opened and carries out diacolation, control diacolation speed is generally 1000g medicinal materials 2~3ml of outflow per minute, filtrate are put into liquid container, and ethanol when emptying is poured into liquid container；Percolate is merged quiet Put, stand for standby use, as component 1.

6. the preparation method of the capsule of the Chinese medicine preparation of gallbladder polyps is treated according to claim 4, it is characterised in that institute State in step b, the stripped raw material dregs of a decoction are steeped in water, heating extraction 2 times, each 1-2 hours, remove supernatant, merging carries Liquid, the filtration of 100-110 mesh are taken, then is concentrated under reduced pressure relatively through the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 of damming, ultrafiltrate 1.25 filtrate, stand for standby use, into component 2 when density is 80 DEG C.

7. the preparation method of the Chinese medicine preparation of gallbladder polyps is treated according to claim 4, it is characterised in that the step c In, by two kinds of extract solutions of above-mentioned steps extraction, it is put into economic benefits and social benefits vacuum concentrator and mixes, first concentrate the filtrate to 80 DEG C of phases To the concentrate that density is 1.32 ,~5 DEG C of deepfreezes are set to 0 24 hours；Refrigeration liquid is added to 0.3% filter aid diatomite, mistake Filter, filtrate are inserted in economic benefits and social benefits vacuum concentrator again, are concentrated into every 1ml medicinal extract containing 0.1g, are added dextrin to modulate grain, are filled after disinfection Enter capsule.

8. a kind of preparation method for the Chinese medicine preparation that gallbladder polyps are treated as any one of claims 1 to 3, its feature exist In when the formulation of the Chinese medicine preparation is tablet, preparation method can also comprise the following steps：

C, above two component is merged, concentrated, film-making.

9. the preparation method of the tablet of the Chinese medicine preparation of gallbladder polyps is treated according to claim 8, it is characterised in that described In step a, take bulk drug to add and soaked in the 5-10 times of ethanol measured 1-2 hours, heating extraction 2 times, each 1-2 hours, merged Extract solution, supernatant is removed after standing, then 100-120 mesh filters, then surpasses through the ultrafiltration post that molecular weight is 5000-10000 that dams Filter, ultrafiltrate be concentrated under reduced pressure relative density for 80 DEG C when 1.36 medicinal extract, stand for standby use, turn into component 1；In the step b, take The dregs of a decoction for the bulk drug that above-mentioned ethanol extracted add 10 times of amount water, heating and refluxing extraction 2 times, 1~2 hour every time, 2 times are extracted Liquid, which merges, to be stood, and turns into component 2.

10. the preparation method of the tablet of the Chinese medicine preparation of gallbladder polyps is treated according to claim 8, it is characterised in that institute State in step c, by the merging of component 1 and component 2, be then placed in and be concentrated under reduced pressure in tank, ethanol is recovered under reduced pressure, it is dense to be concentrated into decoction Spend for 0.6g crude drugs/mL, 1.16 when the relative density filtered to filtrate is 20 DEG C；Above-mentioned filtrate is inhaled through the macropore that volume is 10L After attached resin column absorption, with the deionized water or distillation water elution of 10 times of resin column volumes, then 95% with 5 times of resin column volumes Ethanol elution, ethanol eluate is collected, remove solvent, obtain film-making after medicinal powder is dried.