CN106889605A - A kind of blood fat-reducing blood pressure-decreasing red yeast rice composition and preparation method thereof - Google Patents
A kind of blood fat-reducing blood pressure-decreasing red yeast rice composition and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention discloses a kind of blood fat-reducing blood pressure-decreasing red yeast rice composition and preparation method thereof, the raw material composition of the composition is calculated by weight as：10 ~ 13 parts of 33 ~ 38 parts of red yeast rice micropowders, 15 ~ 18 parts of konjaku glucomannan, 18 ~ 22 parts of black fungus micropowders, 10 ~ 13 parts of purslane, 1 ~ 3 part of common fig leaf juice, 4 ~ 6 parts of folium cortex eucommiae, 4 ~ 6 parts of Chinese chestnut leaf, 6 ~ 8 parts of yncaria stem with hooks, 10 ~ 12 parts of pine nut, 3 ~ 6 parts of corn stigma and golden wave.The present invention utilizes the compatibility relationship of monarch, with red yeast rice as monarch drug in a prescription, konjaku glucomannan, black fungus, corn stigma and pine nut are ministerial drug, purslane, folium cortex eucommiae, Chinese chestnut leaf and common fig leaf juice are adjutant, yncaria stem with hooks and golden wave serve the effect of significant regulation blood fat and cholesterol levels to make medicine, can reduce human body TC, TG value and improve HDL c values simultaneously, hypotensive can also be played a part of simultaneously, promote the normal operation of body glycometabolism.
Description
Technical field
The invention belongs to field of health care food, and in particular to a kind of blood fat-reducing blood pressure-decreasing red yeast rice composition and preparation method thereof.
Background technology
With the quickening and growth in the living standard of people's rhythm of life, the change of people's dietary structure is caused, plus
The deep processing of upper food, is seriously damaged original composition and trace element in food, increasingly affects the health of people.It is high
, used as two kinds of common diseases of modern, its incidence of disease is being continuously increased, and the crowd of morbidity also tends to youth for blood fat and hypertension
Change.
Hyperlipemia is the used title of abnormalities of sugar/lipid metabolism, refers mainly to serum total cholesterol（TC）Or triglycerides（TG）Level
Too high or serum High Density Lipoprotein Cholesterol（HDL-c）Level is too low.Hypertension is with blood pressure rising as main clinical manifestation
Syndrome, be often accompanied by the systemic disease of the organ injuries such as the heart, brain, kidney, main artery, retina.When systolic pressure is more than or equal to
139mmHg, diastolic pressure can be diagnosed as hypertension more than or equal to 89mmHg.At present treatment high fat of blood, hypertension medicine it is most
It is Western medicine, side effect is big, and the body that long-term taking can give people causes damage.
Red yeast rice be it is a kind of by seed selection can produce the high content lipid-reducing function factor strain fermentation rice be prepared from, because of it
Particular matter containing a kind of Monacolin K (Monacolin-K), it is pressed down by Reverse transcriptase reductase HMG-COA
Cholesterol biosynthesis processed, can obviously reduce blood lipid level, the primary raw material of its medicine for having turned into current reducing blood lipid and health food.
However, individually eating red yeast rice, not only effect is limited, and easily causes the symptoms such as intestines discomfort.Therefore, by red yeast rice and its
After its component carries out compatibility, its curative effect can be significantly played, and eliminate its malaise symptoms for bringing.
The content of the invention
It is an object of the invention in view of the shortcomings of the prior art, providing a kind of blood fat-reducing blood pressure-decreasing red yeast rice composition and its preparation
Method.The present invention using monarch compatibility relationship, with red yeast rice as monarch drug in a prescription, konjaku glucomannan, black fungus, corn stigma and
Pine nut is ministerial drug, and purslane, folium cortex eucommiae, Chinese chestnut leaf and common fig leaf juice are adjutant, and yncaria stem with hooks and golden wave serve significantly to make medicine
Regulation blood fat and cholesterol levels effect, can reduce human body TC, TG value and simultaneously raising HDL-c values, while can also rise
To the effect of hypotensive, promote the normal operation of body glycometabolism.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of blood fat-reducing blood pressure-decreasing red yeast rice composition, counts by weight, and its raw material composition is：33 ~ 38 parts of red yeast rice micropowders,
15 ~ 18 parts of konjaku glucomannan, 18 ~ 22 parts of black fungus micropowders, 10 ~ 13 parts of purslane, 1 ~ 3 part of common fig leaf juice, folium cortex eucommiae 4
10 ~ 13 parts of ~ 6 parts, 4 ~ 6 parts of Chinese chestnut leaf, 6 ~ 8 parts of yncaria stem with hooks, 10 ~ 12 parts of pine nut, 3 ~ 6 parts of corn stigma and golden wave.
Preferably, a kind of blood fat-reducing blood pressure-decreasing red yeast rice composition, counts by weight, and its raw material composition is：Red yeast rice ultra micro
35 parts of fine powder, 16 parts of konjaku glucomannan, 20 parts of black fungus micropowders, 11 parts of purslane, 2 parts of common fig leaf juice, folium cortex eucommiae 5
Part, 5 parts of Chinese chestnut leaf, 7 parts of yncaria stem with hooks, 11 parts of pine nut, 4 parts of corn stigma and 12 parts of golden wave.
The particle diameter of the red yeast rice micropowders is 1800 mesh；The preparation method of the black fungus micropowders is：Will be black
After agaric is dried, black fungus micropowders are obtained by ultramicro grinding, particle diameter is 1800 mesh.
A kind of preparation method of blood fat-reducing blood pressure-decreasing red yeast rice composition as described above, specifically includes following steps：
（1）Purslane, common fig leaf juice, folium cortex eucommiae, Chinese chestnut leaf, yncaria stem with hooks, corn stigma and golden wave are mixed by weight ratio after, plus
Enter 12 ~ 15 times of water of weight of mixture, extracted after boiling 2 times, 60 minutes every time, extract solution twice was collected and merged in filtering, then
By gained extract solution EAT be 240 DEG C, 80 DEG C of outlet temperature, spray drying temperature be 180 DEG C under conditions of sprayed
Mist is dried, and obtains mixed-powder A；
（2）Konjaku glucomannan and pine nut are crushed respectively and 600 mesh sieves are crossed, mixed powder B is obtained after mixing；
（3）Lipid-loweringing is obtained after mixed-powder A, mixed powder B, red yeast rice micropowders and black fungus micropowders are sufficiently mixed
Step-down red yeast rice composition.
The beneficial effects of the present invention are：
（1）The present invention utilizes the compatibility relationship of monarch, with red yeast rice as monarch drug in a prescription, konjaku glucomannan, black fungus, corn stigma
It is ministerial drug with pine nut, purslane, folium cortex eucommiae, Chinese chestnut leaf and common fig leaf juice are adjutant, and yncaria stem with hooks and golden wave serve aobvious to make medicine
The regulation blood fat of work and the effect of cholesterol levels, can reduce human body TC, TG value and improve HDL-c values simultaneously, while can also
Play a part of hypotensive, promote the normal operation of body glycometabolism；
（2）Preparation method of the present invention is simple, and edible safety does not have any toxic and side effect, can be eaten for a long time.
Specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described, but the present invention is not limited only to these embodiments.
Embodiment 1
A kind of preparation method of blood fat-reducing blood pressure-decreasing red yeast rice composition, specifically includes following steps：
（1）10g purslanes, common fig leaf juice 1g, folium cortex eucommiae 4g, Chinese chestnut leaf 4g, yncaria stem with hooks 6g, corn stigma 3g and golden wave 10g are mixed
After conjunction, 12 times of water of weight of mixture are added, extracted after boiling 2 times, 60 minutes every time, filtering was collected and merged and extracts twice
Liquid, then by gained extract solution EAT be 240 DEG C, 80 DEG C of outlet temperature, spray drying temperature be 180 DEG C under conditions of enter
Row spray drying, obtains mixed-powder A；
（2）15g konjaku glucomannans and 10g pine nuts are crushed respectively and 600 mesh sieves are crossed, mixed powder B is obtained after mixing；
（3）Made after mixed-powder A, mixed powder B, 33g red yeast rices micropowders and 18g black fungus micropowders are sufficiently mixed
Obtain blood fat-reducing blood pressure-decreasing red yeast rice composition.
Embodiment 2
A kind of preparation method of blood fat-reducing blood pressure-decreasing red yeast rice composition, specifically includes following steps：
（1）13g purslanes, common fig leaf juice 3g, folium cortex eucommiae 6g, Chinese chestnut leaf 6g, yncaria stem with hooks 8g, corn stigma 6g and golden wave 13g are mixed
After conjunction, 15 times of water of weight of mixture are added, extracted after boiling 2 times, 60 minutes every time, filtering was collected and merged and extracts twice
Liquid, then by gained extract solution EAT be 240 DEG C, 80 DEG C of outlet temperature, spray drying temperature be 180 DEG C under conditions of enter
Row spray drying, obtains mixed-powder A；
（2）18g konjaku glucomannans and 12g pine nuts are crushed respectively and 600 mesh sieves are crossed, mixed powder B is obtained after mixing；
（3）Made after mixed-powder A, mixed powder B, 38g red yeast rices micropowders and 22g black fungus micropowders are sufficiently mixed
Obtain blood fat-reducing blood pressure-decreasing red yeast rice composition.
Embodiment 3
A kind of preparation method of blood fat-reducing blood pressure-decreasing red yeast rice composition, specifically includes following steps：
（1）11g purslanes, common fig leaf juice 2g, folium cortex eucommiae 5g, Chinese chestnut leaf 5g, yncaria stem with hooks 7g, corn stigma 4g and golden wave 12g are mixed
After conjunction, 13 times of water of weight of mixture are added, extracted after boiling 2 times, 60 minutes every time, filtering was collected and merged and extracts twice
Liquid, then by gained extract solution EAT be 240 DEG C, 80 DEG C of outlet temperature, spray drying temperature be 180 DEG C under conditions of enter
Row spray drying, obtains mixed-powder A；
（2）16g konjaku glucomannans and 11g pine nuts are crushed respectively and 600 mesh sieves are crossed, mixed powder B is obtained after mixing；
（3）Made after mixed-powder A, mixed powder B, 35g red yeast rices micropowders and 20g black fungus micropowders are sufficiently mixed
Obtain blood fat-reducing blood pressure-decreasing red yeast rice composition.
First, toxicity zoopery
Acute toxicity test：Using NIH mouse 40, SPF grades, male and female half and half, 18~22g of body weight carries out acute toxicity examination
Test.Mouse is randomly divided into two groups, every group 20, i.e. control group and administration group, fasting 12 hours before experiment；By implementation of the invention
Example 1 prepares composition and is dissolved in water,（Concentration is 6.58g crude drugs/ml, maximum concentration）Gavage, gavage volume is 5ml/kg
（I.e. unit dosage form is 32.9 crude drugs/kg）, control group gives normal saline, is administered 2 times within one day, during dosing interval
Between 6 hours, Continuous Observation 14 days after administration, and record the toxic reaction and death toll of mouse.Test result indicate that：With compare
Group compares, and mouse has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increasing after administration
Length is normal.Embodiment 2 and 3 is tested with same experiment.
Test result shows that product of the invention is safe and nontoxic.2nd, clinical test
（1）Reducing blood lipid is tested
100, a collection of crowd's sample with high fat of blood is randomly selected, wherein man 50, female 50,25~55 years old age.By men and women,
Age equal assortment, is divided into 5 groups.Wherein group 1 is to take the experimental group of common hypolipidemic, and group 2 is to take the embodiment of the present invention 1
Product experimental group, group 3 is the experimental groups of the product for taking the embodiment of the present invention 2, and group 4 is to take the embodiment of the present invention 3
The experimental group of product, group 5 is blank control group, i.e., do not take any medicine.Test period continues two months, normal in two months
Diet, drug administration three times per day, each 0.5g, as a result as shown in table 1：
The lipids contents test result of table 1
As shown in Table 1, take TC, TG and HDL-c content of the patient of the present composition after 2 months and return to normal value,
Illustrate that composition of the invention can reduce hyperlipemic patients serum TG（Triglycerides）、TC（Cholesterol）And it is highly dense to improve serum
Degree lipoprotein cholesterol（HDL-c）, there are good effects to regulation blood fat, its effect is substantially better than group 1 and group 5.
（2）Hypotensive is tested
100, a collection of crowd's sample with hypertension is randomly selected, wherein man 50, female 50,25~55 years old age.By men and women,
Age equal assortment, is divided into 5 groups.Wherein group 1 is to take the experimental group of common hypotensor, and group 2 is to take the embodiment of the present invention 1
Product experimental group, group 3 is the experimental groups of the product for taking the embodiment of the present invention 2, and group 4 is to take the embodiment of the present invention 3
The experimental group of product, group 5 is blank control group, i.e., do not take any medicine.Test period continues 1 month, is normally drunk in 1 month
Food, drug administration three times per day, as a result as shown in table 2：
The pressure value test result of table 2
From table 2 it can be seen that taking the patient of the present composition after 1 month, its average blood pressure has been returned to normal level,
As can be seen here, composition of the invention can play a part of to significantly reduce blood pressure, and its effect is substantially better than group 1 and group 5.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with
Modification, should all belong to covering scope of the invention.
Claims (4)
1. a kind of blood fat-reducing blood pressure-decreasing red yeast rice composition, it is characterised in that：Count by weight, the raw material composition of the composition
For：33 ~ 38 parts of red yeast rice micropowders, 15 ~ 18 parts of konjaku glucomannan, 18 ~ 22 parts of black fungus micropowders, purslane 10 ~
13 parts, 1 ~ 3 part of common fig leaf juice, 4 ~ 6 parts of folium cortex eucommiae, 4 ~ 6 parts of Chinese chestnut leaf, 6 ~ 8 parts of yncaria stem with hooks, 10 ~ 12 parts of pine nut, 3 ~ 6 parts of corn stigma
With 10 ~ 13 parts of golden wave.
2. blood fat-reducing blood pressure-decreasing red yeast rice composition according to claim 1, it is characterised in that：Count by weight, described group
The raw material of compound is constituted：35 parts of red yeast rice micropowders, 16 parts of konjaku glucomannan, 20 parts of black fungus micropowders, dent
11 parts of amaranth, 2 parts of common fig leaf juice, 5 parts of folium cortex eucommiae, 5 parts of Chinese chestnut leaf, 7 parts of yncaria stem with hooks, 11 parts of pine nut, 4 parts of corn stigma and golden wave 12
Part.
3. blood fat-reducing blood pressure-decreasing red yeast rice composition according to claim 1 and 2, it is characterised in that：The red yeast rice is ultra tiny
The particle diameter of powder is 1800 mesh；The preparation method of the black fungus micropowders is：After black fungus is dried, by ultramicro grinding system
Black fungus micropowders are obtained, particle diameter is 1800 mesh.
4. the method that one kind prepares the blood fat-reducing blood pressure-decreasing red yeast rice composition as any one of claim 1 ~ 3, its feature exists
In：Specifically include following steps：
（1）Purslane, common fig leaf juice, folium cortex eucommiae, Chinese chestnut leaf, yncaria stem with hooks, corn stigma and golden wave are mixed by weight ratio after, plus
Enter 12 ~ 15 times of water of weight of mixture, extracted after boiling 2 times, 60 minutes every time, extract solution twice was collected and merged in filtering, then
By gained extract solution EAT be 240 DEG C, 80 DEG C of outlet temperature, spray drying temperature be 180 DEG C under conditions of sprayed
Mist is dried, and obtains mixed-powder A；
（2）Konjaku glucomannan and pine nut are crushed respectively and 600 mesh sieves are crossed, mixed powder B is obtained after mixing；
（3）Lipid-loweringing is obtained after mixed-powder A, mixed powder B, red yeast rice micropowders and black fungus micropowders are sufficiently mixed
Step-down red yeast rice composition.
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Application publication date: 20170627 |