CN106879593A - A kind of alkalescent low corrosion Peracetic acid effervescent tablet disinfectant - Google Patents
A kind of alkalescent low corrosion Peracetic acid effervescent tablet disinfectant Download PDFInfo
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- CN106879593A CN106879593A CN201710017167.2A CN201710017167A CN106879593A CN 106879593 A CN106879593 A CN 106879593A CN 201710017167 A CN201710017167 A CN 201710017167A CN 106879593 A CN106879593 A CN 106879593A
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- acid
- disinfectant
- sodium
- effervescent tablet
- peracetic acid
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
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Abstract
A kind of being obtained in that is more easy to storage transport, makes the alkalescent peracetic acid disinfectant effervescent tablet disinfectant that peracetic acid soln is more stable, corrosivity is smaller of preparation, is made up of tetraacetyl ethylene diamine, peroxide, gas-producing disintegrant, surfactant, binder, coating membrane, stabilizer and corrosion inhibiter, peroxyacetic acid concentration indicator.
Description
Technical field
The present invention relates to a kind of alkalescent low corrosion Peracetic acid effervescent tablet disinfectant.
Background technology
Used as traditional pasteurization material, chlorine-containing disinfecting material effects mechanism is hydrolysis generation hypochlorous acid molecule, using secondary chlorine
The oxidation sterilizing of acid molecule.But use chlorine-containing disinfectant sterilize when, by hypochlorous acid molecule HCIO decomposite time
Chlorate ions (OCL-), easily forms carcinogen chloroform (CHCL with impurities in water3) or trichlorophenol, so seldom making now
Carried out disinfection with chlorine-containing disinfectant, and generally use peroxide sterilants.
Peroxide sterilants have Strong oxdiative ability, and various microorganisms are very sensitive to it, can kill all microorganisms
Go out.This kind of disinfectant is including hydrogen peroxide, Peracetic acid, chlorine dioxide and ozone etc..Their advantage is in article after sterilizing
On leave no residue toxicity, non-carcinogenesis.Someone is researched and produced disinfectants with rich carboxylic macromolecular material in recent years, such as：
Peroxidating acrylic acid (sodium salt), peroxidating maleic acid (sodium salt), methyl acrylic acid (sodium salt) and peroxidating fumaric acid (sodium
Salt) etc..
Wherein, Peracetic acid (CH3COOOH) it is a kind of widely used quick-acting, efficient, low toxicity, broad-spectrum disinfectant, can be with
Kill various bacterial propagules, mould, virus, gemma.Preventing and controlling hospital-acquired infection and large-scale infectious disease (such as atypia
Property pneumonia, bird flu, H1N1) break out in played an important role.It is low with valid density；Work fast etc.
Premium properties, catabolite is acetic acid and oxygen, is had no side effect.But traditional peroxyacetic acid disinfectant exists in liquid form, surely
Qualitative difference, it is not easy to maintain, it is numerous dominant with recessive application risk with more explosive, severe corrosive etc..
Chinese patent literature 1 (CN1128257A) and patent document 2 (CN15422000A) disclose Peracetic acid solid
The technical scheme of the preparation method of medicament.The former tetraacetyl ethylene diamine and coated place of (CN1128257A) coated treatment
The sodium perborate of reason is mixed by certain molar ratio, and then the solid dissolving of the mixing is produced in a certain amount of normal-temperature water
Peracetic acid, although solve and be difficult storage, transport and awkward problem, but dissolubility is poor, produces speed slowly, effectively
Composition is volatile；The latter (CN15422000A) is by acetyl-containing activator, inorganic peroxide and surfactant formation of solid polycomplex
Medicament, although accelerate the speed of producing of Peracetic acid, but still without solving, Stability of Acetic acid peroxide is poor, and corrosivity is high to ask
Topic.
Chinese patent literature 3 (CN102415380A) disclose it is a kind of by tetraacetyl ethylene diamine, inorganic peroxide, it is cloudy from
The solid producer of sub- surfactant and anticorrosive composition, in this scenario, although solve stability to a certain extent
And corrosion problems, but solution ph is not controlled, (peroxide need to be under weak basic condition just with acyl compounds
Peracetic acid can be generated, and when alkaline too strong, the Peracetic acid fast decoupled of generation causes the utilization rate relatively low).Chinese patent
Document 4 (CN102964285A) disclose it is a kind of by acetylsalicylic acid, it is tetraacetyl ethylene diamine, SODIUM PERCARBONATE, surfactant, slow
Erosion agent and the solid producer of pH adjusting agent composition, in this scenario, although solution ph is controlled, but it is not right
Formulation technique claims, is still required without addition peroxide stabiliser, to dissolving water temperature, need to mix step, dissolving speed
Degree is slow, corrosivity still some height.
Existing market Its Accompanying Solid Peracetic Acid propellant is generally that a certain amount of powder is loaded in mixture or two-component packaging, dissolution velocity is slow,
External force is needed to mix；Powder loads in mixture easily caking and is unfavorable for storage, and product mixing degree is unreliable and is unfavorable for the amount of demand hour
Take, application place scope is limited, and corrosivity is big, there is sterilization objects compared with macrolesion.What is added without peroxyacetic acid stabilizing agent
In the case of, Peracetic acid is easily decomposed, and usage cycles are short.
In general, Peroxyacetic acid generator needs to solve in the presence of obvious defect.Such as：
1st, water reaction is being dissolved in using peroxide and Acyl activating thing, when preparing liquid Peracetic acid, is commonly using acyl group and live
Agent is tetraacetyl ethylene diamine, density 0.9, is slightly soluble in water, needs external force to stir when preparing Peracetic acid and promotes dissolving, reaction it is slow and
The water surface easily is swum in, influence is used；Simultaneously to promote its dissolving, largely using surfactant, rinsing difficulty is increased.
2nd, existing Peracetic acid solid producer is that powder and particle are loaded in mixture, therefore is difficult to mix, is not easy to determining for small demand
Sample is measured, using limited；And easily moisture absorption is lumpd, it is unfavorable for preservation steady in a long-term.
3rd, Peracetic acid belongs to strong oxidizer, and the use for having larger corrosivity, poorly efficient corrosion inhibiter to metal can not be protected fully
Shield is sterilized object,
4th, Stability of Acetic acid peroxide is poor, easily decomposes to give off oxygen, and so as to cause the reduction of effective content, prior art is not related to
And the use of peroxyacetic acid stabilizing agent, therefore its usage cycles is shorter.
The content of the invention
In view of above-mentioned technical problem, it is more easy to storage transport, makes preparation present invention aim at a kind of being obtained in that is provided
Peracetic acid soln is more stable, corrosivity is smaller, be more conducive to the alkalescent peracetic acid disinfectant effervescent tablet of different use demands
Disinfectant.
Specifically, the present invention provides a kind of peracetic acid disinfectant effervescent tablet disinfectant, it is characterised in that by four acetyl second two
Amine, peroxide, gas-producing disintegrant, surfactant, binder, coating membrane, stabilizer and corrosion inhibiter composition.
Further, a kind of peracetic acid disinfectant effervescent tablet disinfectant is provided according to the invention described above, it is characterised in that institute
Peroxide is stated using SODIUM PERCARBONATE (also referred to as sodium carbonate peroxide).
Further, a kind of peracetic acid disinfectant effervescent tablet disinfectant is provided according to the invention described above, it is characterised in that by
Tetraacetyl ethylene diamine, SODIUM PERCARBONATE, gas-producing disintegrant, surfactant, binder, coating membrane, stabilizer, corrosion inhibiter and peroxide
Acetic acid concentration indicator is constituted, the tetraacetyl ethylene diamine, SODIUM PERCARBONATE, gas-producing disintegrant, surfactant, binder, bag
Clothing film, stabilizer, corrosion inhibiter and peroxyacetic acid concentration indicator are sequentially according to mass ratio：1: 1~2: 0.05~1.2: 0.05
~0.5: 0.5~1: 0.05~0.5: 0.3~1.2: 0.1~0.4: 0.0001~0.1.
Further, a kind of peracetic acid disinfectant effervescent tablet disinfectant is provided according to the invention described above, it is characterised in that institute
Stating gas-producing disintegrant not only can only select acid disintegrant but also can be with the acid and alkaline disintegrant of simultaneous selection, disintegrant energy simultaneously
It is enough that pH value is controlled, so that the product of different specifications can be applicable under different PH environment.In the present invention, the bubble
Rising disintegrant can be only with solid acid disintegrant, when water is met, the basic species that acid is generated after being decomposed in itself with SODIUM PERCARBONATE
Matter reacts, and produces great amount of carbon dioxide, makes disintegration of tablet.If the acid disintegrant of selection, the gas-producing disintegrant can be with
Selected from SODIUM PERCARBONATE and tartaric acid, SODIUM PERCARBONATE and citric acid, SODIUM PERCARBONATE and salicylic acid, SODIUM PERCARBONATE and benzoic acid, cross carbon
One kind in sour sodium and boric acid and SODIUM PERCARBONATE and sulfamic acid.
In order to preferably realize quick dissolving, can be with the acid and alkaline disintegrant of simultaneous selection.The effervesce disintegration
Agent can be selected from sodium carbonate or sodium acid carbonate and tartaric acid, sodium carbonate or sodium acid carbonate and citric acid, sodium carbonate or sodium acid carbonate
With organic phosphoric acid, sodium carbonate or sodium acid carbonate and benzoic acid, sodium carbonate or sodium acid carbonate and boric acid, sodium carbonate or sodium acid carbonate with
One kind in sulfamic acid.
Or, the acid disintegrant is selected from solid acid, optimization citric acid, tartaric acid, sulfamic acid or organic phosphoric acid.
The alkaline disintegrant is selected from carbonate, bicarbonate or disodium hydrogen phosphate, preferably sodium carbonate, sodium acid carbonate.
Peracetic acid disinfectant effervescent tablet disinfectant of the invention, its monolithic quality size is not limited, and also can behave as bubble
Rise pulvis or pill
According to above-mentioned peracetic acid disinfectant effervescent tablet disinfectant, it is characterised in that the surfactant is selected from amino
Acid surfaces activating agent, AEO, APES, fatty alkyl polyglycol ether and polyethylene glycol are pungent
At least one in the nonionic surfactants and anion surfactant such as base phenyl ether, neopelex.
According to above-mentioned peracetic acid disinfectant effervescent tablet disinfectant, it is characterised in that described binder is with coating membrane by gathering
At least one composition in vinylpyrrolidone, cellulose derivative, polyethylene glycol, crylic acid resin, wherein cellulose spreads out
Biology includes hydroxypropyl methyl cellulose or hydroxypropyl cellulose or sodium carboxymethylcellulose or hydroxypropyl methyl cellulose phthalandione
At least one in ester.
According to above-mentioned peracetic acid disinfectant effervescent tablet disinfectant, it is characterised in that described stabilizer is selected from D-Glucose
Answered at least 2 kinds in sour sodium, disodium edta, inorganic phosphate, organophosphor acids and organic phosphate, silicate
Match somebody with somebody.Wherein inorganic phosphate includes that calgon, sodium pyrophosphate are at least one；Silicate modulus are not less than 1.8.
According to above-mentioned peracetic acid disinfectant effervescent tablet disinfectant, it is characterised in that described corrosion inhibiter is aoxidized selected from metal
In thing, borate ester, polyalcohols, silicate, sodium molybdate, BTA, organophosphor acids and organic phosphate extremely
It is few a kind.
According to above-mentioned peracetic acid disinfectant effervescent tablet disinfectant, the peroxyacetic acid concentration indicator can use various cities
Sell indicator, it is preferred that the present invention is using light blue as indicator.
The present invention is not the simple combination of the related reagent in patent document 1~4, in fact, Peracetic acid is used as disappearing
Toxic agent is built consensus on sterilization circle, and it is easy to volatilize and is all the time industry with strong sharp aroma and corrosivity
The problem of facing, patent document 1~4 is actually also to prepare and occur in Its Accompanying Solid Peracetic Acid overcoming these problems
Agent, some addition PH conditioning agents, some addition surfactants etc., although it has the advantages that protrusion in one aspect, and
It is then helpless in other respects.Patent document 1 improves stability when producing Peracetic acid, but sacrifices dissolubility, specially
Sharp document 2 in turn increases dissolubility and produces speed, but sacrifices stability, and patent document 3 and patent document 4 are solved
Stability and corrosivity, and reaction process can be held, but thus dissolution velocity can reduce, and in technique
Requirement greatly increase, preparation condition is harsh to be complicated.And the present invention is then by adding gas-producing disintegrant, adhesive, coating
Film, stabilizer, corrosion inhibiter and peroxyacetic acid concentration indicator, and the proportioning of each component of keeping under strict control can produce satisfaction respectively
The product that item is required.Even so, in some embodiments of the invention, still can use for reference disclosed in these patent documents
Cucumber.Those skilled in the art will appreciate that what these materials were merely exemplary, the present invention is not limited in these
Among specific material.
Effervescent tablet disinfectant according to the present invention, by four acetyl second two involved in various combination the application
Amine, SODIUM PERCARBONATE, surfactant, gas-producing disintegrant, binder, stabilizer, corrosion inhibiter etc., it is possible to achieve identical invention mesh
, the tablet of different size, pulvis or pill etc..
Sterilization effervescent tablet disinfectant according to the present invention, due to by tetraacetyl ethylene diamine, SODIUM PERCARBONATE, surface-active
Agent, gas-producing disintegrant, binder, stabilizer, corrosion inhibiter composition, so, it is more easy to storage transport.Further, it is different by setting
Tablet quality, controls the Peracetic acid amount of generation, can facilitate different occasions, different purposes, the use of different demands amount.
Sterilization effervescent tablet disinfectant according to the present invention, due to containing gas-producing disintegrant, causes under effervescent effect
Dissolving is accelerated, and is mixed without external force, low to water temperature requirement, and reaction speed faster, and reduces the consumption of surfactant, is beneficial to
Rinsing；On the other hand, due to the stabilizer and corrosion inhibitor formula that there is efficient, low concentration, so the peroxide second of preparation can be made
Acid solution is more stable, corrosivity is smaller.
Sterilization effervescent tablet disinfectant according to the present invention, due to containing peroxyacetic acid concentration indicator, it is possible to
Real-time monitoring is carried out to peroxyacetic acid concentration, the proportion relation between the component that can keep under strict control can be designed and meet various performances
It is required that product.
Specific embodiment
The present invention is described in detail below by specific embodiment.
The peracetic acid disinfectant effervescent tablet disinfectant that the present invention is provided, is disintegrated by tetraacetyl ethylene diamine, peroxide, effervesce
Agent, surfactant, binder, coating membrane, stabilizer and corrosion inhibiter composition, it should be pointed out that Peracetic acid of the invention
Effervescent tablet needs to be prepared in drying or in the job shop equipped with dehumidification equipment, to ensure the performance and stabilization of the tablet
Property.
In the present invention, preferably, the peroxide uses SODIUM PERCARBONATE.SODIUM PERCARBONATE is also known as peroxide
Sodium carbonate, with strong oxidizing property.It is pointed out that SODIUM PERCARBONATE is the material that infringement is can result in environment, needed when using
Professional operation is wanted, can not arbitrarily be lost and be abandoned.
Further, in the present invention, peroxyacetic acid concentration indicator, the tetraacetyl ethylene diamine, SODIUM PERCARBONATE, bubble are added
Disintegrant, surfactant, binder, coating membrane, stabilizer, corrosion inhibiter and peroxyacetic acid concentration indicator are risen according to mass ratio
It is sequentially：1: 1~2: 0.05~1.2: 0.05~0.5: 0.5~1: 0.05~0.5: 0.3~1.2: 0.1~0.4: 0.0001~
0.1。
In the present invention, the surfactant, corrosion inhibiter etc. can be using the examinations disclosed in patent document 1~4
Agent, as long as it meets invention thinking of the invention, you can reference is used, if it should be noted, however, that using for reference these examinations
Agent in inventive formulation ratio, it is necessary to be modulated, if formula is beyond dosage range of the invention, although it can make
It is standby go out effervescent tablet of the invention, but its stability or dissolution velocity be it cannot be guaranteed that.Formula of the invention is this hair
The classical formula that bright R＆D team obtains by up to ten thousand experiments, but the present invention is not limited to these classics formulas, this area skill
Art personnel should be appreciated that this point.
In the present invention, the gas-producing disintegrant not only can only select acid disintegrant but also can be with simultaneous selection acidity and alkali
Property disintegrant, disintegrant can be controlled to pH value simultaneously, can be applicable different specifications under different PH environment
Product.In the present invention, the gas-producing disintegrant can be only with solid acid disintegrant, when water is met, sour and SODIUM PERCARBONATE sheet
The alkaline matter generated after status solution reacts, and produces great amount of carbon dioxide, makes disintegration of tablet.If the acid disintegration of selection
Agent, the gas-producing disintegrant can selected from SODIUM PERCARBONATE and tartaric acid, SODIUM PERCARBONATE and citric acid, SODIUM PERCARBONATE and salicylic acid,
One kind in SODIUM PERCARBONATE and benzoic acid, SODIUM PERCARBONATE and boric acid and SODIUM PERCARBONATE and sulfamic acid.
In order to preferably realize quick dissolving, can be with the acid and alkaline disintegrant of simultaneous selection.The effervesce disintegration
Agent can be selected from sodium carbonate or sodium acid carbonate and tartaric acid, sodium carbonate or sodium acid carbonate and citric acid, sodium carbonate or sodium acid carbonate
With organic phosphoric acid, sodium carbonate or sodium acid carbonate and benzoic acid, sodium carbonate or sodium acid carbonate and boric acid, sodium carbonate or sodium acid carbonate with
One kind in sulfamic acid.
In the present invention, the surfactant selected from AEO nonionic surfactant or the moon from
At least one in sub- surfactant.Why these are selected as surfactant, because can cause of the invention clear
Wash effect more preferable.However, in the present invention, the surfactant can also selected from anion surfactant or
One kind or several mixtures of nonionic surfactant, such as：Neopelex, lauryl sodium sulfate, 12
Sodium alkyl sulfonate, fatty alkyl polyglycol ether and Triton X-100 etc..It is also selected from being lived in non-ionic surface
Property agent or anion surfactant in others are a kind of or several mixtures, such as：Amino acid surfactant, fat
Alcohol APEO, APES etc., do not list one by one as space is limited.
In the present invention, described binder and coating membrane are by polyvinylpyrrolidone, cellulose derivative, poly- second two
At least one composition in alcohol, crylic acid resin, wherein cellulose derivative includes hydroxypropyl methyl cellulose or hydroxypropyl
At least one in cellulose or sodium carboxymethylcellulose or hydroxypropyl methyl cellulose phthalate.
In the present invention, described stabilizer is selected from inorganic phosphate, organophosphor acids and organic phosphate, silicate
In at least 2 kinds compounding.Wherein inorganic phosphate includes that calgon, sodium pyrophosphate are at least one；Silicate modulus are not less than
1.8。
In the present invention, corrosion inhibiter is selected from metal oxide, sodium molybdate, BTA, organophosphor acids and organophosphor
At least a kind in Barbiturates.
In the present invention, the peroxyacetic acid concentration indicator can use various commercially available indicator, it is preferred that the present invention
Using light blue as indicator.
Sterilization effervescent tablet disinfectant according to the present invention, by peroxide, tetraacetyl ethylene diamine, surface-active
The various combinations of agent, gas-producing disintegrant etc., it is possible to achieve the tablet of different size, pulvis or pill etc., to meet different occasions
The individual needs of different clients.
Sterilization effervescent tablet disinfectant according to the present invention, due to by coating membrane, stabilizer, peroxide, four acetyl
Ethylenediamine, surfactant, gas-producing disintegrant etc. constitute tablet, so being more easy to storage transport.Further, by setting different
Agent quality, controls the Peracetic acid amount of generation, can facilitate different occasions, different purposes, the use of different demands amount.
Sterilization effervescent tablet disinfectant according to the present invention, due to containing gas-producing disintegrant, causes under effervescent effect
Dissolving is accelerated, and is mixed without external force, low to water temperature requirement, and reaction speed faster, and reduces the consumption of surfactant, is beneficial to
Rinsing；On the other hand, due to the stabilizer and corrosion inhibitor formula that there is efficient, low concentration, so the peroxide second of preparation can be made
Acid solution is more stable, corrosivity is smaller.
Below by specific embodiment, the present invention is described in detail.
Embodiment 1
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, sodium acid carbonate 1.8g, tartaric acid 5.0g, neopelex
0.6g, sodium carboxymethylcellulose 2.0g, calgon 1.0g, 1-hydroxy ethylidene-1,1-diphosphonic acid 0.6g, BTA 0.2g and bright
Blue 0.005g, fully mixes and is pressed into different size tablet.
According to the embodiment, it is high to be obtained stability, and dissolution velocity is fast, the effervescent tablet of low-corrosiveness.
Embodiment 2
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, sodium acid carbonate 1.8g, citric acid 5.0g, AEO
0.3g, sodium carboxymethylcellulose 2.0g, calgon 1.0g, sodium metasilicate 0.4g, 1-hydroxy ethylidene-1,1-diphosphonic acid 0.4g, the nitrogen of benzo three
Azoles 0.2g and light blue 0.005g are fully mixed and are pressed into different size tablet.
Embodiment 3
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, sodium acid carbonate 1.8g, citric acid 5.0g, dodecyl sodium sulfate
0.5g, sodium carboxymethylcellulose 2.0g, sodium polyphosphate 1.6g, 1-hydroxy ethylidene-1,1-diphosphonic acid 0.4g, BTA 0.2g and bright
Blue 0.005g is fully mixed and is pressed into different size tablet.
Embodiment 4
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, sodium acid carbonate 1.8g, citric acid 5.0g, dodecyl sodium sulfate
0.5g, polyvinylpyrrolidone 1.6g, sodium polyphosphate 1.6g, 1-hydroxy ethylidene-1,1-diphosphonic acid 0.4g, pentaerythrite 0.2g and light blue
0.005g is fully mixed and is pressed into different size tablet.
Embodiment 5
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, sodium carbonate 1.5g, citric acid 5.0g, dodecyl sodium sulfate
0.5g, polyvinylpyrrolidone 1.6g, sodium polyphosphate 1.6g, 1-hydroxy ethylidene-1,1-diphosphonic acid 0.2g, borate 1.0g and light blue
0.005g is fully mixed and is pressed into different size tablet.
Embodiment 6
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, sodium acid carbonate 1.8g, citric acid 5.0g, dodecyl sodium sulfate
0.5g, hydroxypropyl methyl cellulose 1.2g, calgon 1.0g, sodium metasilicate 0.4g, PEG-4000 0.5g, benzo three
Nitrogen azoles 0.2g and light blue 0.005g are fully mixed and are pressed into different size tablet.
Counter-example 1
Tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, neopelex 0.6g are fully mixed and formed.
Counter-example 2
Tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, citric acid 3.0g, neopelex 0.6g are fully mixed
Form.
Counter-example 3
By tetraacetyl ethylene diamine 5g, SODIUM PERCARBONATE 10g, citric acid 3.0g, neopelex 0.6g, sodium molybdate
0.5g is fully mixed and formed.
According to version in 2002《Disinfection technology standard》Sterile products inspection technology specification, determines above-described embodiment gained respectively
Dissolution velocity, stability of solution, metal protection, the product stability of effervescent tablet and counter-example gained mixing powder.Its total amount
According to being shown in Table 1.
The Its Accompanying Solid Peracetic Acid performance parameter of the different embodiments of table 1
Embodiment 1-6 gained effervescent tablets are dissolved in 1L room temperature waters, are disintegrated completely in 2min, generated when 5min is completely dissolved
Peroxyacetic acid concentration reaches 0.10%, 30min generation peroxyacetic acid concentrations and reaches 0.25%, and it is long to maintain more than 0.1%
Up to 55h.And counter-example 1-3 dissolution times are averagely more than 26min, so as to cause Peracetic acid formation speed slow and stabilization time
It is extremely short；According to version in 2002《Disinfection technology standard》Sterile products inspection technology specification, determines above-described embodiment gained bubble respectively
Rise piece and counter-example to stainless steel, carbon steel, copper, aluminium metal protection, embodiment 1-6 is right to stainless steel, copper no corrosion
Aluminium, carbon steel mild corrosion, show that the present invention can break through use scope and the field of peroxyacetic acid disinfectant.And counter-example to copper,
Carbon steel, aluminium are all severe corrosion, are to restrict the key factor that peroxyacetic acid disinfectant is used.By embodiment 1-6 gained effervescent tablets
Packed with reagent bottle sealing preserve respectively with counter-example 1-3 gained powder samples, stability was carried out using the method for 37 DEG C/3 months
Determine, as a result show, under the same terms, the effervescent tablet Peracetic acid growing amount after experiment in 37 DEG C/3 months averagely declines little
In 0.32%, and appearance character is basically unchanged, and the Peracetic acid growing amount average rate of decrease of counter-example sample is all higher than
18.71%, and caking, flatulence are serious.
To sum up, although the present invention is made a detailed description for specific embodiment, but it is to be understood that these are said
It is bright be it is exemplary, protection scope of the present invention is not limited only among these specific embodiments, for those skilled in the art
For, the present invention can be made various changes and modifications within the scope of present inventive concept and spirit not departing from, these are repaiied
Changing and changing to fall within the scope and spirit of the invention, and protection scope of the present invention is defined by the following claims.
Claims (9)
1. a kind of peracetic acid disinfectant effervescent tablet disinfectant, it is characterised in that including tetraacetyl ethylene diamine, peroxide, effervesce
Disintegrant, surfactant, binder, coating membrane, stabilizer and corrosion inhibiter.
2. peracetic acid disinfectant effervescent tablet disinfectant as claimed in claim 1, it is characterised in that the peroxide used carbon
Sour sodium.
3. peracetic acid disinfectant effervescent tablet disinfectant as claimed in claim 2, it is characterised in that further include that Peracetic acid is dense
Degree indicator, the tetraacetyl ethylene diamine, SODIUM PERCARBONATE, gas-producing disintegrant, surfactant, binder, coating membrane, stabilization
Agent, corrosion inhibiter and peroxyacetic acid concentration indicator are sequentially according to mass ratio：1: 1~2: 0.05~1.2: 0.05~0.5: 0.5
~1: 0.05~0.5: 0.3~1.2: 0.1~0.4: 0.0001~0.1.
4. the peracetic acid disinfectant effervescent tablet disinfectant as described in above-mentioned claim 3, it is characterised in that the surfactant choosing
From in amino acid surfactant, AEO, APES, fatty alkyl polyglycol ether and poly-
In the nonionic surfactants such as ethylene glycol octyl phenyl ether, neopelex and anion surfactant at least
It is a kind of.
5. the peracetic acid disinfectant effervescent tablet disinfectant as described in above-mentioned claim 3, it is characterised in that described binder and bag
Clothing film is made up of at least one in polyvinylpyrrolidone, cellulose derivative, polyethylene glycol, crylic acid resin, wherein
Cellulose derivative includes hydroxypropyl methyl cellulose or hydroxypropyl cellulose or sodium carboxymethylcellulose or hydroxypropyl methyl fibre
At least one in the plain phthalate ester of dimension.
6. the peracetic acid disinfectant effervescent tablet disinfectant as described in above-mentioned claim 3, it is characterised in that described stabilizer is selected from
In maltonic acid sodium, disodium edta, inorganic phosphate, organophosphor acids and organic phosphate, silicate extremely
Few 2 kinds of compoundings.Wherein inorganic phosphate includes that calgon, sodium pyrophosphate are at least one；Silicate modulus are not less than 1.8.
7. the peracetic acid disinfectant effervescent tablet disinfectant as described in above-mentioned claim 3, it is characterised in that described corrosion inhibiter is selected from
Metal oxide, borate ester, polyalcohols, silicate, sodium molybdate, BTA, organophosphor acids and organic phosphate
At least a kind in class.
8. the effervescent tablet according to required by right 3, its acid disintegrant is selected from solid acid, optimization citric acid, tartaric acid, amino
Sulfonic acid or organic phosphoric acid.Alkaline disintegrant is selected from carbonate, bicarbonate or disodium hydrogen phosphate, preferably sodium carbonate, sodium acid carbonate.
9. the peracetic acid disinfectant effervescent tablet disinfectant as described in above-mentioned claim 1, its monolithic quality size is not limited, can also showed
It is effervesce pulvis or pill.
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| CN107410310A (en) * | 2017-08-18 | 2017-12-01 | 王金强 | A kind of peracetic acid in single-ingredient disinfection solution and preparation method thereof |
| CN108047113A (en) * | 2017-12-14 | 2018-05-18 | 广州中冠动物药业有限公司 | A kind of synthesis technology of Peracetic acid |
| CN109156476A (en) * | 2018-10-23 | 2019-01-08 | 广州市凯迪新医学科技有限公司 | Unitary package sterilization powder and preparation method thereof |
| CN109231412A (en) * | 2018-10-25 | 2019-01-18 | 西南交通大学 | A kind of method that ferrous ion activation Peracetic acid removes Diclofenac in water removal |
| CN110684601A (en) * | 2018-07-05 | 2020-01-14 | 漳州甘净日用品有限公司 | Corrosion-free type washing machine tank decontamination sterilization effervescent tablet and preparation method thereof |
| CN111065273A (en) * | 2017-08-16 | 2020-04-24 | 法国诗华大药厂 | Novel disinfectant for hatcheries |
| CN111234943A (en) * | 2020-03-02 | 2020-06-05 | 惠州市多美日用品有限公司 | Aerobic laundry explosive ball and preparation method thereof |
| CN111449067A (en) * | 2020-05-08 | 2020-07-28 | 山东卓健医疗科技有限公司 | Alkalescent peroxyacetic acid solution |
| CN112790191A (en) * | 2021-01-06 | 2021-05-14 | 海韵一剑大卫生科技有限公司 | Low-temperature peracetic acid disinfectant and preparation method thereof |
| CN114847289A (en) * | 2022-06-16 | 2022-08-05 | 深圳市质量安全检验检测研究院 | Acid virus nucleic acid degradation disinfection method |
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| CN111065273A (en) * | 2017-08-16 | 2020-04-24 | 法国诗华大药厂 | Novel disinfectant for hatcheries |
| CN107410310A (en) * | 2017-08-18 | 2017-12-01 | 王金强 | A kind of peracetic acid in single-ingredient disinfection solution and preparation method thereof |
| CN108047113A (en) * | 2017-12-14 | 2018-05-18 | 广州中冠动物药业有限公司 | A kind of synthesis technology of Peracetic acid |
| CN110684601A (en) * | 2018-07-05 | 2020-01-14 | 漳州甘净日用品有限公司 | Corrosion-free type washing machine tank decontamination sterilization effervescent tablet and preparation method thereof |
| CN109156476A (en) * | 2018-10-23 | 2019-01-08 | 广州市凯迪新医学科技有限公司 | Unitary package sterilization powder and preparation method thereof |
| CN109231412A (en) * | 2018-10-25 | 2019-01-18 | 西南交通大学 | A kind of method that ferrous ion activation Peracetic acid removes Diclofenac in water removal |
| CN111234943A (en) * | 2020-03-02 | 2020-06-05 | 惠州市多美日用品有限公司 | Aerobic laundry explosive ball and preparation method thereof |
| CN111449067A (en) * | 2020-05-08 | 2020-07-28 | 山东卓健医疗科技有限公司 | Alkalescent peroxyacetic acid solution |
| US20210345606A1 (en) * | 2020-05-08 | 2021-11-11 | SHANDONG ZHUOJIAN MEDICAL TECHNOLOGY Co.,Ltd. | Weakly alkaline peracetic acid solution |
| CN112790191A (en) * | 2021-01-06 | 2021-05-14 | 海韵一剑大卫生科技有限公司 | Low-temperature peracetic acid disinfectant and preparation method thereof |
| CN114847289A (en) * | 2022-06-16 | 2022-08-05 | 深圳市质量安全检验检测研究院 | Acid virus nucleic acid degradation disinfection method |
| CN114847289B (en) * | 2022-06-16 | 2024-05-31 | 深圳市质量安全检验检测研究院 | Acid virus nucleic acid degradation disinfection method |
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