CN106857523A - A kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate - Google Patents
A kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate Download PDFInfo
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- CN106857523A CN106857523A CN201710247139.XA CN201710247139A CN106857523A CN 106857523 A CN106857523 A CN 106857523A CN 201710247139 A CN201710247139 A CN 201710247139A CN 106857523 A CN106857523 A CN 106857523A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- Pest Control & Pesticides (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The present invention relates to a kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate, the weight ratio of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is 1 80:80 1, for preventing and treating the fungal diseases such as wheat scab, bakanae disease of rice, synergistic effect is obvious.
Description
Technical field：
The invention belongs to field of agricultural fungicide, a kind of Bactericidal composite containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is specifically related to
Thing and its application.
Background technology：
2-cyano-3-amino-3-phenylancryic acetate (phenamacril), tested number：JS399-19, chemical name is：2- cyano group -3- amino -3- phenyl
Ethyl acrylate.Synthesized by Jiangsu Prov. Inst. of Agricultural Chemicals, be the new type bactericide with the autonomous intellectual property of China.The medicament
Resistance of rainwater washing against, with good interior suction penetration performance and excellent protection and therapeutic action.2-cyano-3-amino-3-phenylancryic acetate is to Fusarium
Fusarium graminearum, fusarium moniliforme, Fusarium oxysporum etc. have bioactivity very high, it is adaptable to which wheat scab, paddy rice are disliked
Effective preventing and treating of the crop disease such as seedling diseases and watermelon blight.
Desk research shows that gibberellic hypha easily develops immunity to drugs in the medicament selection pressure high of such medicament, there is one
Fixed resistance risk.Therefore in the case where current disease-resistant variety lacks, in order to delay or overcoming the drug-fast shape of pathogen
Into and development, it is to avoid continuous single use 2-cyano-3-amino-3-phenylancryic acetate, should with other kinds of bactericide rotation or be used in mixed way.
SYP-3375 (coumoxystrobin), chemical name：(E) -2- (2- (methyl-coumarin -7- of 3- normal-butyls -4
Base epoxide) aminomethyl phenyl) -3- methoxy-methyl acrylates.CAS registration numbers are：850881-70-8.SYP-3375 belongs to methoxy
Base acrylic bactericide, the compound III of its electron transport chain for acting on fungal mitochondria prevents electron transmission, suppresses
Energy synthesizes.There is good inhibiting effect to various pathogens such as apple tree canker, ring spot.And due to its mechanism of action list
One, long-term reuse may cause fungal bacterial strain to produce selectivity under many circumstances on Field information, and the bacterial strain is to fourth
Fragrant bacterium ester forms the resistance for adapting to, and causes SYP-3375 even invalid to the reduction of these fungi preventive effects, causes disease to expand,
Crop failure, agricultural chemicals is wasted.
Due to the exploitation of novel pesticide, not only investment risk is big, and environmental protection and food security require it to improve, limit
System adds sternly, so its construction cycle is more long.And scientific and reasonable agriculture chemical compounding can not only improve prevention effect, increase quick-acting
Property, extend the lasting period, expand preventing and treating spectrum, dosage, reduces cost etc. are reduced, but also can overcome or delay harmful organism
The generation or development of resistance, extend the service life of agricultural chemicals, reduce environmental pollution, and Protect natural enemies, biometric safeguard diversity keeps
The ecological balance.Therefore, various new agriculture chemical compounding agents are able to numerous studies as a kind of effective means of preventing and treating harmful organism
And exploitation, its production scale constantly expands, and number of applications is also on the increase, and weight has been made in terms of higher yield of crops high-quality is protected
Big contribution, has very great meaning (meter Feng Yu, Hua Zhong Agriculture University's Master's thesis) to development social now and in the future.
We screen and on the basis of field test, filter out SYP-3375 and compounded with 2-cyano-3-amino-3-phenylancryic acetate indoors, have
There is obvious synergistic effect, after further study, complete the present invention.
The content of the invention：
The technical problem to be solved in the present invention is to provide that a kind of bactericidal effect is good, and the prevention effect to wheat scab etc. shows
Write the composition of synergy.In order to solve the above technical problems, present invention offer technical scheme is as follows：
A kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate, it is characterised in that described bactericidal composition is with fourth
Fragrant bacterium ester and 2-cyano-3-amino-3-phenylancryic acetate are active ingredient, and the weight ratio of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is 1-64:64-1, preferred weight ratio
It is 1-32:32-1, is still more preferably 1-16:16-1, the content of active ingredient is 1-85%, preferably 20-75%.
Composition of the invention is used for the fungal diseases such as wheat scab, bakanae disease of rice
The preparation formulation that the present composition can be prepared according to the method well known to those skilled in the art of the present technique, including
Water dispersible granules, wettable powder, missible oil, suspending agent, oil suspending agent, suspension emulsion, aqueous emulsion, microemulsion etc.；What can be selected helps
Agent has emulsifying agent, wetting dispersing agent, suspending agent, disintegrant, binding agent, antifreezing agent, thickener, stabilizer, defoamer etc..
Composition of the invention has the following advantages：
1st, composition of the present invention has synergistic function.
2nd, rationally, treatment adds protective effect to instant component, and bactericidal effect is good, it is possible to reduce times for spraying, drug cost
It is low, slow down the generation of resistance, it is good to crop safety.
3rd, the present invention has preferable prevention effect to wheat scab, bakanae disease of rice.
Specific embodiment：
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight ratio, but this hair
It is bright to be not limited thereto.
1st, toxicity is determined
Synergy determines (one)
The connection of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate mixture to wheat scab is illustrated below by synergy determination test
Cooperation is used.
In order to prevent and treat fusarium graminearum (Fusarium graminearum), we are answered SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate
With synergy measure is carried out, specific test method and result are as follows.
Toxicity Determination method is：By SYP-3375,2-cyano-3-amino-3-phenylancryic acetate active compound, according to the matched proportion density of setting, it is configured to
Required liquid, it is standby.Test method is referred to《NY/T 1156.2-2006 farm-chemical indoor determination test rules bactericide
2 parts：Suppress disease fungus mycelial growth experiment Plating》.
Aseptically, the advance culture medium for melting is quantitatively adding in aseptic conical flask, from low concentration to high concentration
Liquid is quantitatively drawn successively, above-mentioned conical flask is separately added into, and is fully shaken up.Then equivalent pours into the training that 3 diameter above are 9cm
Support in ware, be made the pastille flat board of respective concentration.Treatment without medicament is used as blank.It is repeated 4 times.
By cultured pathogen, aseptically, with the card punch of diameter 5mm, beaten from colony edge and take bacterium dish, used
Bacterium dish is inoculated in pastille flat board center by transfer needle, is cultivated 4 days at 25 DEG C of temperature, and crossing method determines measurement colony diameter,
Effective middle dosage (EC that different disposal suppresses pathogen growth 50% is calculated according to formula below50Value), and compare antibacterial activity.
The synergistic effect of antimicrobial combination is evaluated by Wadley methods, single dose A, B and mixture AB is built respectively first
Dose-response curve, by the way that after logistic value-logarithm or most appropriate probability-Logarithm conversion, dose-response curve is converted
It is straight line, the EC that different preventing is controlled under level is calculated accordingly50Or EC90Value.Theoretical value (the E=(a+b)/[(a/ of calculation composition
ECA)+(b/ECB)], wherein E is theoretical value, and a is ratio of the 2-cyano-3-amino-3-phenylancryic acetate single dose in mixture, and b is SYP-3375 single dose mixed
Ratio in agent, ECAIt is the EC of 2-cyano-3-amino-3-phenylancryic acetate single dose50Value, ECBIt is the EC of SYP-3375 single dose50Value) and coefficient of synergism (combination
Measured value/the theoretical value of thing).Synergy of the compound drug to fusarium graminearum is evaluated with coefficient of synergism, actual preventive effect with
The ratio between theoretical preventive effect is more than 1, as synergistic effect.
Synergy measurement result of the composition of the invention of table 1 to fusarium graminearum
Synergy measurement result shows：2-cyano-3-amino-3-phenylancryic acetate and SYP-3375 in table 1 ratio 32:1~1:32 use with, to small
Wheat gibberellic hypha has certain synergistic effect, when ratio is 1:When 1, synergistic effect is the most obvious, while it has been found that increasing
Effect effect has certain randomness, such as 1:Coefficient of synergism is maximum when 1, to 1:It is when 8 and smaller, 1:Increase again when 16
Greatly, the phenomenon of non-curve is shown.
Toxicity determines (two)：
In order to prevent and treat the bakanae disease of rice in agricultural production, inventor has been carried out mutually multiple with SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate
The synergy matched somebody with somebody is studied, and specific method is：
Subjects：Fusarium moniliforme (Fusarium moniliforme), test method reference《Chinese people's republicanism
State agricultural industry criteria NY/T1156.2-2006》.Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients first.To melt
The PDA culture medium of change is cooled to 60-70 DEG C, and quantitative pharmacy is added by design flow, is made the pastille culture medium containing different doses,
It is repeated 3 times, after its is sufficiently cool, is inoculated with the fusarium moniliforme bacterium dish of a diameter of 5mm, 25 DEG C is adjusted for incubated 7 days
Look into, colony growth diameter of each treatment is measured respectively, and calculate bacteriostasis rate, by the probit value of inhibiting rate and series concentration
Linear regression analysis between logarithm value, obtains the EC of each medicament50Value, theoretical value and increasing with Wadley method calculation compositions
Effect coefficient, activity of the reagent agent to germ is evaluated with this.
The 2-cyano-3-amino-3-phenylancryic acetate of table 2 combines the indoor synergy measurement result to fusarium moniliforme with SYP-3375
Synergy measurement result shows：2-cyano-3-amino-3-phenylancryic acetate and SYP-3375 in table 2 ratio 64:1~1:64 use with, to water
Rice Fusarium moniliforme Sheld is respectively provided with synergistic effect.
2nd, example of formulations
The processing technology of the various formulations of the present composition is prior art, can be varied from according to different situations.
Embodiment 1：50% SYP-3375 2-cyano-3-amino-3-phenylancryic acetate wettable powder
SYP-3375 25%, 2-cyano-3-amino-3-phenylancryic acetate 25%, sodium lignin sulfonate 5%, neopelex 5%, Tea Saponin
10%, white carbon 5%, attapulgite complements to 100%.
Embodiment 2：25% SYP-3375 2-cyano-3-amino-3-phenylancryic acetate missible oil
SYP-3375 5%, 2-cyano-3-amino-3-phenylancryic acetate 20%, calcium dodecyl benzene sulfonate 10%, NPE 15% gathers
PAA 7%, soybean oil adds to 100%.
Embodiment 3：25% SYP-3375 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
SYP-3375 20%, 2-cyano-3-amino-3-phenylancryic acetate 5%, sodium lignin sulfonate 5%, neopelex 8%, ammonium sulfate
2%, kaolin complements to 100%.
Embodiment 4：51% SYP-3375 2-cyano-3-amino-3-phenylancryic acetate suspending agent
SYP-3375 50%, 2-cyano-3-amino-3-phenylancryic acetate 1%, neopelex 13%, APES 5% is yellow
Virgin rubber 2%, propane diols 1%, adds water to 100g.
Embodiment 5：40% SYP-3375 2-cyano-3-amino-3-phenylancryic acetate microemulsion
SYP-3375 10%, 2-cyano-3-amino-3-phenylancryic acetate 30%, aliphatic acid polyethenoxy ether 15%, calcium lignosulfonate 4%,
Glycerine 2%, azone 1%, water complements to 100%.
Embodiment 6：60% SYP-3375 2-cyano-3-amino-3-phenylancryic acetate oil-suspending agent
SYP-3375 10%, 2-cyano-3-amino-3-phenylancryic acetate 50%, Arlacel-60 6%, AEO
4%, styrylphenol polyoxyethylene ether 3%, castor oil polyoxyethylene ether 4%, organobentonite 1%, aerosil
0.5%, urea 2%, mineral oil supplies 100%.
3rd, field control effectiveness test
Reagent agent：Preparation in embodiment 1-6.
Comparison medicament：20% SYP-3375 suspending agent (comparison medicament 1), 25% 2-cyano-3-amino-3-phenylancryic acetate suspending agent (comparison medicament 2).
Preventing and treating crop：Wheat.
Prevent and kill off object：Wheat scab.
Test method：Test in being carried out in wheat paddock, each group processes 3 repetitions, processing area is about 20m2, according to
The area of experimental plot, the good various medicaments of precise, in the first time dispenser of wheat flowering initial stage, second dispenser after 3-5d,
Disease investigation, the activity of relatively more various medicaments are carried out after 20 days.The results are shown in Table 3.
The field control effectiveness test result of the SYP-3375 of table 3 and 2-cyano-3-amino-3-phenylancryic acetate to wheat scab
| Treatment agent | Consumption (ga.i/ mus) | Disease refers to preventive effect (%) |
| Embodiment 1 | 20 | 88.62 |
| Embodiment 2 | 20 | 90.14 |
| Embodiment 3 | 20 | 88.25 |
| Embodiment 4 | 20 | 90.57 |
| Embodiment 5 | 20 | 87.26 |
| Embodiment 6 | 20 | 91.67 |
| Comparison medicament 1 | 30 | 78.48 |
| Comparison medicament 2 | 25 | 84.51 |
Field experiment result shows that the compounding of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is preferable to the preventive effect of wheat scab, with list
Agent is compared, and preventive effect is enhanced, and synergistic effect is obvious.Estimated according to field, in the range of test dose, plant growth
Normally, have no that plant produces poisoning and anomaly, to wheat safety.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, on the premise of principle of the present invention is not departed from, some improvements and modifications can also be made, these improvements and modifications
Should be regarded as protection scope of the present invention.
Claims (6)
1. a kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate, it is characterised in that described bactericidal composition is with cloves
Bacterium ester and 2-cyano-3-amino-3-phenylancryic acetate are active ingredient, and the weight ratio of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is 1-64:64-1.
2. composition according to claim 1, it is characterised in that the weight of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is than preferred weight ratio
It is 1-32:32-1, is still more preferably 1-16:16-1.
3. according to any described compositions of claim 1-2, it is characterised in that the cumulant of SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate is
The 1%-85% of the composition total weight, preferably 20%-75%.
4. a kind of compound disinfectant, it is characterised in that comprising permitting on any described compositions of claim 1-3 and pesticidal preparations
Perhaps conven-tional adjuvants are configured to any one formulation allowed on agricultural chemicals.
5. bactericide according to claim 4, it is characterised in that the formulation be water dispersible granules, wettable powder, missible oil,
Aqueous suspension agent, oil suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
6. the bactericide of the composition of claim 1-3 or claim 4-5 is used to prevent and treat wheat scab, bakanae disease of rice etc.
The application of fungal disease.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710247139.XA CN106857523A (en) | 2017-04-17 | 2017-04-17 | A kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710247139.XA CN106857523A (en) | 2017-04-17 | 2017-04-17 | A kind of bactericidal composition containing SYP-3375 and 2-cyano-3-amino-3-phenylancryic acetate |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283215A (en) * | 2011-08-31 | 2011-12-21 | 陕西上格之路生物科学有限公司 | Germicide composition containing coumoxystrobin |
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- 2017-04-17 CN CN201710247139.XA patent/CN106857523A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283215A (en) * | 2011-08-31 | 2011-12-21 | 陕西上格之路生物科学有限公司 | Germicide composition containing coumoxystrobin |
Non-Patent Citations (2)
| Title |
|---|
| 关爱莹等: "杀菌剂丁香菌酯（coumoxystrobin）", 《世界农药》 * |
| 刘永泉主编: "《农药新品种实用手册》", 30 May 2012, 中国农业出版社 * |
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