CN106822265A - A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection - Google Patents

A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection Download PDF

Info

Publication number
CN106822265A
CN106822265A CN201710212402.1A CN201710212402A CN106822265A CN 106822265 A CN106822265 A CN 106822265A CN 201710212402 A CN201710212402 A CN 201710212402A CN 106822265 A CN106822265 A CN 106822265A
Authority
CN
China
Prior art keywords
environment
friendly type
inactivator
virus infection
human papilloma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710212402.1A
Other languages
Chinese (zh)
Inventor
杨涵
李忠泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710212402.1A priority Critical patent/CN106822265A/en
Publication of CN106822265A publication Critical patent/CN106822265A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, part by mass percentage, including cationic antibacterial agent 0.1 0.2%, L-Epicatechin gallate 1.2 2.0%, honeysuckle flower 1.2 2.0%, the radix paeoniae rubrathe 2.0 4.0%, ethanol 2.0 5.0%, peppermint 0.6 1.0%, 100% is complemented to purified water.Dodecyl benzyl dimethyl ammonium chloride of the present invention, DDAC, the mixed good anti-bacterial effect of diformazan alkyl amine-oxides, the antibiotic rate of cationic antibacterial agent sterilized logarithm value more than 4 in 1 minute to bone marrow poliomyelitis virus.

Description

A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection
Technical field
The present invention relates to antiseptic technical field, more particularly to a kind of environment-friendly type antibiotic for treating human papilloma virus infection Inactivator.
Background technology
HPV is a kind of papilloma vacuolating virus A category for belonging to papovaviridae, is spherical DNA virus, The scaly epithelium of human body skin mucous membrane can be caused to breed.Show as the symptoms such as verruca vulgaris, genital wart (condyloma acuminatum).With property The incidence of disease of condyloma acuminatum rapidly rises and increases with cervical carcinoma, cancer of anus etc. in disease, and HPV (HPV) infection is more next More cause the concern of people.The HPV of high-risk-type is closely related with genital tract precancerous lesion and malignant tumour, HPV's DNA is often incorporated on the chromosome of host cell.According to statistics in the venereal disease in the whole world, the genital wart that HPV infection causes is accounted for 15-20%.People are in the urgent need to a kind for the treatment of human papilloma virus that are effective, can having been played good result by most people confirmation The environment-friendly type antibiotic inactivator of poison infection.
Chinese patent, Authorization Notice No.：The B of CN 102480952, patent name does not have to indicate epicatechin in antiseptic Infanticide acid esters has excellent stability and antibiotic property obstruction bacterium infection.But its sterilization effect can not be reached in the short period again 100% sterilization effect.
The content of the invention
Based on the technical problem that background technology is present, the present invention proposes a kind of environmental protection for treating human papilloma virus infection Type anti-microbial deactivation agent.
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection proposed by the present invention, by mass percentage Part, including cationic antibacterial agent 0.1-0.2%, L-Epicatechin gallate 1.2-2.0%, honeysuckle flower 1.2-2.0%, the radix paeoniae rubrathe 2.0-4.0%, ethanol 2.0-5.0%, peppermint 0.6-1.0%, 100% is complemented to purified water.
Preferably, also including Radix Glycyrrhizae 1.8-2.5%, safflower 2.5-4.0%.
Preferably, also including Radix Isatidis 3.5-4.8%, false pineapple 2.5-3.5%.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC, Diformazan alkyl amine-oxides are according to 3-5: 2-3: 1 ratio is mixed to get.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, comprises the following steps：
1) honeysuckle flower, the radix paeoniae rubrathe, Radix Glycyrrhizae, safflower, Radix Isatidis, the raw material of false pineapple are weighed in proportion；
2) by step 1) raw material drying, fine powder is ground into, sieve, sterilized under uviol lamp, it is standby；
3) by step 2) sterilized raw material are added to the water, and it is secondary to add water to cook extraction, adds water for the first time 10 times and measures, Decoct 2-3 hours, leach liquid, the dregs of a decoction continue to add water 10 times and measure, decoct 2-3 hours, leach liquid, the dregs of a decoction are discarded, filtrate is closed And；
4) in step 3) add L-Epicatechin gallate and peppermint in the solution that obtains, be sufficiently stirred for, after be concentrated into Relative density is determined as 1.10~1.15 for 65-70 DEG C in temperature, obtains aqueous solvent, cooling；
5) ethanol is added to step 4) in the solution that obtains, and stirring dissolves it；
6) in step 5) add cationic antibacterial agent and purified water in the solution that obtains, cationic antibacterial agent and purified water with Slow way is added and ceaselessly stirred, and it is fully dissolved, and obtains product.
Honeysuckle flower：The sweet cold air fragrance of its property, without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil for clear heat with drugs of sweet flavour and cold nature.Honeysuckle flower can surname dissipate wind Heat, is also apt to removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, hair spot, heat toxin sore carbuncle, abscess of throat card.
The radix paeoniae rubrathe：Can clearing heat and cooling blood, blood stasis removing analgesic.Cure mainly warm heat disease heat and enter ying blood, dermexanthesis hair spot, hematemesis and epistaxis, hot eyes swells Bitterly, liver depression costalgia , wei lump in the abdomen stomachache, traumatic injury, carbuncle swells sore etc..Cardiovascular system can be improved, increase heart perfusion flow, with anti- Blood coagulation, improves immunologic function, to bacillus dysenteriae, staphylococcus, Pseudomonas aeruginosa, capital section 68-1 viruses and herpus vivus Etc. there is inhibitory action.
Radix Glycyrrhizae：Mild-natured, sweet, return 12 warps are a kind of help Chinese herbal medicines；Licorice can be clearing heat and detoxicating, moistens the lung and relieve the cough, and adjusts With all property of medicine；Can also invigorate the spleen and benefit qi, expelling phlegm and arresting coughing, relieving spasm to stop pain.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, cough phlegm Many, gastral cavity abdomen and four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Safflower：It is warm in nature, taste is pungent, invigorate blood circulation, blood stasis removing analgesic, for Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, bruise Damage.
Radix Isatidis：Property it is bitter, tremble with fear, the thoughts of returning home, stomach.Function is clearing heat and detoxicating, cool blood relieving sore-throat.Cure mainly influenza, epidemic meningitis, encephalitis, Pneumonia, erysipelas, heat toxin hair spot, coma hematemesis, pharynx swelling, mumps, pinkeye, sore rash, tongue dark reddish purple dark, larynx numbness, scarlet fever, infection with swollen head Epidemic disease, carbuncle swells；Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
False pineapple：Can clearing heat and detoxicating, inducing diuresis to remove edema.Kidney stone is cured mainly, urinary tract infections, nephritic dropsy, hyperpyrexia of catching a cold is coughed Cough, hepatitis, orchitis etc., can also control rheumatalgia, dysentery, stomachache.
In the present invention, 1, dodecyl benzyl dimethyl ammonium chloride, DDAC, diformazan alkyl amine-oxides Mixed good anti-bacterial effect, the antibiotic rate of cationic antibacterial agent existed in 1 minute to bone marrow poliomyelitis virus sterilizing logarithm value More than 4；
2nd, cationic antibacterial agent combination L-Epicatechin gallate, antibiotic rate is significantly improved, and 0.5 minute antibiotic rate can be with Up to 100%.
Specific embodiment
The present invention is made with reference to specific embodiment further explain.
Embodiment 1
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, by mass percentage part, including cation Antiseptic 0.1%, L-Epicatechin gallate 1.2%, honeysuckle flower 2.0%, the radix paeoniae rubrathe 4.0%, Radix Glycyrrhizae 2.5%, safflower 2.5%, Radix Isatidis 3.5%, false pineapple 3.5%, ethanol 2.0%, peppermint 0.6%, 100% is complemented to purified water.
Wherein, cationic antibacterial agent is dodecyl benzyl dimethyl ammonium chloride, DDAC, bismethane Base amine-oxides are mixed to get according to 3: 2: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including Following steps：
1) honeysuckle flower, the radix paeoniae rubrathe, Radix Glycyrrhizae, safflower, Radix Isatidis, the raw material of false pineapple are weighed in proportion；
2) by step 1) raw material drying, fine powder is ground into, sieve, sterilized under uviol lamp, it is standby；
3) by step 2) sterilized raw material are added to the water, and it is secondary to add water to cook extraction, adds water for the first time 10 times and measures, Decoct 2 hours, leach liquid, the dregs of a decoction continue to add water 10 times and measure, decoct 2 hours, leach liquid, the dregs of a decoction are discarded, filtrate merges；
4) in step 3) add L-Epicatechin gallate and peppermint in the solution that obtains, be sufficiently stirred for, after be concentrated into Relative density is determined as 1.10 for 65 DEG C in temperature, obtains aqueous solvent, cooling；
5) ethanol is added to step 4) in the solution that obtains, and stirring dissolves it；
6) in step 5) add cationic antibacterial agent and purified water in the solution that obtains, cationic antibacterial agent and purified water with Slow way is added and ceaselessly stirred, and it is fully dissolved, and obtains product.
Embodiment 2
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, by mass percentage part, including cation Antiseptic 0.2%, L-Epicatechin gallate 2.0%, honeysuckle flower 1.2%, radix paeoniae rubrathe 2.0-4.0%, Radix Glycyrrhizae 2.5%, safflower 2.5%th, Radix Isatidis 3.5%, false pineapple 2.5%, ethanol 5.0%, peppermint 1.0%, 100% is complemented to purified water.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC, Diformazan alkyl amine-oxides are mixed to get according to 4: 2: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including Following steps：
Step is with embodiment 1, and different specific preparation method parameters is as follows：
First time decocting time 3 hours, second decoction 3 hours；
Relative density is concentrated into temperature for 70 DEG C are determined as 1.15.
Embodiment 3
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, part is anti-including cation by mass percentage Microbial inoculum 0.15%, L-Epicatechin gallate 1.6%, honeysuckle flower 1.8%, the radix paeoniae rubrathe 3.0%, Radix Glycyrrhizae 2.0%, safflower 3.0%, plate Blue root 4.2%, false pineapple 3.0%, ethanol 4.0%, peppermint 0.8%, 100% is complemented to purified water.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC, Diformazan alkyl amine-oxides are mixed to get according to 5: 3: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including Following steps：
Step is with embodiment 1, and different specific preparation method parameters is as follows：
First time decocting time 2.5 hours, second decoction 2.5 hours；
Relative density is concentrated into temperature for 68 DEG C are determined as 1.13.
Embodiment 4
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, by mass percentage part, including cation Antiseptic 0.2%, L-Epicatechin gallate 1.4%, honeysuckle flower 1.8%, the radix paeoniae rubrathe 4.0%, Radix Glycyrrhizae 2.2%, safflower 3.5%, Radix Isatidis 4.0%, false pineapple 3.0%, ethanol 3.0%, peppermint 0.8%, 100% is complemented to purified water.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC, Diformazan alkyl amine-oxides are mixed to get according to 4: 3: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including Following steps：
Step is with embodiment 1, and different specific preparation method parameters is as follows：
First time decocting time 2.8 hours, second decoction 2.3 hours；
Relative density is concentrated into temperature for 66 DEG C are determined as 1.14.
Table 1 is cationic antibacterial agent to bone marrow poliomyelitis virus sterilization effect
Bacterial controls group well-grown.
Conclusion：Under experimental conditions, the disinfectant stock solution, acts on 1min, and the averagely killing to bone marrow poliomyelitis virus is right Numerical value ＞ 4.00 is qualified to sterilize.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto, Any one skilled in the art the invention discloses technical scope in, technology according to the present invention scheme and its Inventive concept is subject to equivalent or change, should all be included within the scope of the present invention.

Claims (5)

1. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that part, bag by mass percentage Include cationic antibacterial agent 0.1-0.2%, L-Epicatechin gallate 1.2-2.0%, honeysuckle flower 1.2-2.0%, radix paeoniae rubrathe 2.0- 4.0%th, ethanol 2.0-5.0%, peppermint 0.6-1.0%, 100% is complemented to purified water.
2. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection according to claim 1, its feature exists In also including Radix Glycyrrhizae 1.8-2.5%, safflower 2.5-4.0%.
3. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection according to claim 1, its feature exists In also including Radix Isatidis 3.5-4.8%, false pineapple 2.5-3.5%.
4. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection according to claim 1, its feature exists In the cationic antibacterial agent is dodecyl benzyl dimethyl ammonium chloride, DDAC, the oxidation of diformazan alkyl Ammonium is according to 3-5: 2-3: 1 ratio is mixed to get.
5. according to a kind of system of any described environment-friendly type antibiotic inactivators for treating human papilloma virus infection of claim 1-3 Preparation Method, it is characterised in that comprise the following steps：
1) honeysuckle flower, the radix paeoniae rubrathe, Radix Glycyrrhizae, safflower, Radix Isatidis, the raw material of false pineapple are weighed in proportion；
2) by step 1) raw material drying, fine powder is ground into, sieve, sterilized under uviol lamp, it is standby；
3) by step 2) sterilized raw material are added to the water, and it is secondary to add water to cook extraction, adds water for the first time 10 times and measures, and decocts 2-3 hours, liquid is leached, the dregs of a decoction continue to add water 10 times and measure, decocted 2-3 hours, leach liquid, the dregs of a decoction are discarded, filtrate merges；
4) in step 3) add L-Epicatechin gallate and peppermint in the solution that obtains, be sufficiently stirred for, after be concentrated into it is relative Density is determined as 1.10~1.15 for 65-70 DEG C in temperature, obtains aqueous solvent, cooling；
5) ethanol is added to step 4) in the solution that obtains, and stirring dissolves it；
6) in step 5) cationic antibacterial agent and purified water are added in the solution that obtains, cationic antibacterial agent and purified water are with slow Mode add and ceaselessly stir, it is fully dissolved, obtain product.
CN201710212402.1A 2017-04-01 2017-04-01 A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection Pending CN106822265A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710212402.1A CN106822265A (en) 2017-04-01 2017-04-01 A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710212402.1A CN106822265A (en) 2017-04-01 2017-04-01 A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection

Publications (1)

Publication Number Publication Date
CN106822265A true CN106822265A (en) 2017-06-13

Family

ID=59142096

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710212402.1A Pending CN106822265A (en) 2017-04-01 2017-04-01 A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection

Country Status (1)

Country Link
CN (1) CN106822265A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108902207A (en) * 2018-06-04 2018-11-30 江苏医药职业学院 A kind of human papilloma virus inactivator and preparation method thereof
CN110613778A (en) * 2019-10-25 2019-12-27 南京特纳斯生物技术开发有限公司 Medicament for controlling HPV infection recurrence and preparation method thereof
CN110664991A (en) * 2019-10-25 2020-01-10 南京特纳斯生物技术开发有限公司 Medicine for treating wart caused by HPV infection and preparation method thereof
CN113813287A (en) * 2021-08-27 2021-12-21 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) Preparation method of compound medicinal liquid for treating verruca vulgaris

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102480952A (en) * 2009-07-31 2012-05-30 国立大学法人大阪大学 Antibacterial agent
CN103860955A (en) * 2014-03-07 2014-06-18 张家能 Traditional Chinese medicine combination for treating human papillomavirus infection and preparation method of traditional Chinese medicine combination

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102480952A (en) * 2009-07-31 2012-05-30 国立大学法人大阪大学 Antibacterial agent
CN103860955A (en) * 2014-03-07 2014-06-18 张家能 Traditional Chinese medicine combination for treating human papillomavirus infection and preparation method of traditional Chinese medicine combination

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈洁生: "微波治疗仪配合消疣汤治疗尖锐湿疣45例", 《实用中医药杂志》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108902207A (en) * 2018-06-04 2018-11-30 江苏医药职业学院 A kind of human papilloma virus inactivator and preparation method thereof
CN110613778A (en) * 2019-10-25 2019-12-27 南京特纳斯生物技术开发有限公司 Medicament for controlling HPV infection recurrence and preparation method thereof
CN110664991A (en) * 2019-10-25 2020-01-10 南京特纳斯生物技术开发有限公司 Medicine for treating wart caused by HPV infection and preparation method thereof
CN113813287A (en) * 2021-08-27 2021-12-21 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) Preparation method of compound medicinal liquid for treating verruca vulgaris

Similar Documents

Publication Publication Date Title
CN106822265A (en) A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection
CN109078165A (en) A kind of composition and the preparation method and application thereof for the nursing of women privates
CN109364207A (en) A kind of composition and preparation method and the application for the treatment of and alleviation acne
CN111671882A (en) Preparation for enhancing immunity and preparation device and method thereof
CN110652544A (en) Pharmaceutical composition for treating rhinitis and preparation method thereof
CN103860955B (en) One is treated human papilloma virus infection Chinese medicine composition and preparation method thereof
CN105613612A (en) Agent for disinfecting intensive care unit and preparation method
CN105079420A (en) Anesthesia ointment for wound surface and preparation method of anesthesia ointment
CN102755597B (en) Chinese medicine for treating acute soft tissue injury
CN103446564B (en) Chinese medicine composition of a kind of anti-inflammation and preparation method thereof
CN103599437B (en) One treats colpitic traditional Chinese medicine liquid
CN107149622A (en) A kind of Chinese medicine for treating rhinitis
CN104906489A (en) Veterinary medicine for treating animal dyspepsia
CN111419997A (en) Traditional Chinese medicine composition for treating condyloma acuminata
CN111035751A (en) Wind-cold conditioning bath powder and preparation method thereof
CN104435222A (en) Traditional Chinese medicinal preparation for preventing and treating ovine bluetongue
CN103417782A (en) Traditional Chinese medicine for treating scald
CN108524797A (en) A kind of preparation method and applications for treating swine fever bacterium solution
CN103341151B (en) Traditional Chinese medicine for treating chronic bronchitis
CN105125801B (en) Spray for relieving itching of puerpera incision and preparation method
CN108272927A (en) Secret medicine is fanned
CN107753670A (en) A kind of traditional Chinese medicinal ointment for treating burn and scald
CN104083733A (en) Traditional Chinese medicine preparation for cold-type children's bronchitis
CN105362993A (en) Tincture for treating ichthyophthiriasis of parrotfish and preparation method of tincture for treating ichthyophthiriasis of parrotfish
CN104906217A (en) Traditional Chinese medicine ointment for treating acute catarrhal conjunctivitis and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20170613

RJ01 Rejection of invention patent application after publication