CN106822265A - A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection - Google Patents
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection Download PDFInfo
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- CN106822265A CN106822265A CN201710212402.1A CN201710212402A CN106822265A CN 106822265 A CN106822265 A CN 106822265A CN 201710212402 A CN201710212402 A CN 201710212402A CN 106822265 A CN106822265 A CN 106822265A
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- environment
- friendly type
- inactivator
- virus infection
- human papilloma
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- 230000003115 biocidal effect Effects 0.000 title claims abstract description 25
- 208000009608 Papillomavirus Infections Diseases 0.000 title claims abstract description 21
- 208000021145 human papilloma virus infection Diseases 0.000 title claims abstract description 20
- 230000000937 inactivator Effects 0.000 title claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 19
- 125000002091 cationic group Chemical group 0.000 claims abstract description 19
- 239000008213 purified water Substances 0.000 claims abstract description 13
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- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims abstract description 8
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, part by mass percentage, including cationic antibacterial agent 0.1 0.2%, L-Epicatechin gallate 1.2 2.0%, honeysuckle flower 1.2 2.0%, the radix paeoniae rubrathe 2.0 4.0%, ethanol 2.0 5.0%, peppermint 0.6 1.0%, 100% is complemented to purified water.Dodecyl benzyl dimethyl ammonium chloride of the present invention, DDAC, the mixed good anti-bacterial effect of diformazan alkyl amine-oxides, the antibiotic rate of cationic antibacterial agent sterilized logarithm value more than 4 in 1 minute to bone marrow poliomyelitis virus.
Description
Technical field
The present invention relates to antiseptic technical field, more particularly to a kind of environment-friendly type antibiotic for treating human papilloma virus infection
Inactivator.
Background technology
HPV is a kind of papilloma vacuolating virus A category for belonging to papovaviridae, is spherical DNA virus,
The scaly epithelium of human body skin mucous membrane can be caused to breed.Show as the symptoms such as verruca vulgaris, genital wart (condyloma acuminatum).With property
The incidence of disease of condyloma acuminatum rapidly rises and increases with cervical carcinoma, cancer of anus etc. in disease, and HPV (HPV) infection is more next
More cause the concern of people.The HPV of high-risk-type is closely related with genital tract precancerous lesion and malignant tumour, HPV's
DNA is often incorporated on the chromosome of host cell.According to statistics in the venereal disease in the whole world, the genital wart that HPV infection causes is accounted for
15-20%.People are in the urgent need to a kind for the treatment of human papilloma virus that are effective, can having been played good result by most people confirmation
The environment-friendly type antibiotic inactivator of poison infection.
Chinese patent, Authorization Notice No.：The B of CN 102480952, patent name does not have to indicate epicatechin in antiseptic
Infanticide acid esters has excellent stability and antibiotic property obstruction bacterium infection.But its sterilization effect can not be reached in the short period again
100% sterilization effect.
The content of the invention
Based on the technical problem that background technology is present, the present invention proposes a kind of environmental protection for treating human papilloma virus infection
Type anti-microbial deactivation agent.
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection proposed by the present invention, by mass percentage
Part, including cationic antibacterial agent 0.1-0.2%, L-Epicatechin gallate 1.2-2.0%, honeysuckle flower 1.2-2.0%, the radix paeoniae rubrathe
2.0-4.0%, ethanol 2.0-5.0%, peppermint 0.6-1.0%, 100% is complemented to purified water.
Preferably, also including Radix Glycyrrhizae 1.8-2.5%, safflower 2.5-4.0%.
Preferably, also including Radix Isatidis 3.5-4.8%, false pineapple 2.5-3.5%.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC,
Diformazan alkyl amine-oxides are according to 3-5: 2-3: 1 ratio is mixed to get.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, comprises the following steps：
1) honeysuckle flower, the radix paeoniae rubrathe, Radix Glycyrrhizae, safflower, Radix Isatidis, the raw material of false pineapple are weighed in proportion；
2) by step 1) raw material drying, fine powder is ground into, sieve, sterilized under uviol lamp, it is standby；
3) by step 2) sterilized raw material are added to the water, and it is secondary to add water to cook extraction, adds water for the first time 10 times and measures,
Decoct 2-3 hours, leach liquid, the dregs of a decoction continue to add water 10 times and measure, decoct 2-3 hours, leach liquid, the dregs of a decoction are discarded, filtrate is closed
And；
4) in step 3) add L-Epicatechin gallate and peppermint in the solution that obtains, be sufficiently stirred for, after be concentrated into
Relative density is determined as 1.10~1.15 for 65-70 DEG C in temperature, obtains aqueous solvent, cooling；
5) ethanol is added to step 4) in the solution that obtains, and stirring dissolves it；
6) in step 5) add cationic antibacterial agent and purified water in the solution that obtains, cationic antibacterial agent and purified water with
Slow way is added and ceaselessly stirred, and it is fully dissolved, and obtains product.
Honeysuckle flower：The sweet cold air fragrance of its property, without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil for clear heat with drugs of sweet flavour and cold nature.Honeysuckle flower can surname dissipate wind
Heat, is also apt to removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, hair spot, heat toxin sore carbuncle, abscess of throat card.
The radix paeoniae rubrathe：Can clearing heat and cooling blood, blood stasis removing analgesic.Cure mainly warm heat disease heat and enter ying blood, dermexanthesis hair spot, hematemesis and epistaxis, hot eyes swells
Bitterly, liver depression costalgia , wei lump in the abdomen stomachache, traumatic injury, carbuncle swells sore etc..Cardiovascular system can be improved, increase heart perfusion flow, with anti-
Blood coagulation, improves immunologic function, to bacillus dysenteriae, staphylococcus, Pseudomonas aeruginosa, capital section 68-1 viruses and herpus vivus
Etc. there is inhibitory action.
Radix Glycyrrhizae：Mild-natured, sweet, return 12 warps are a kind of help Chinese herbal medicines；Licorice can be clearing heat and detoxicating, moistens the lung and relieve the cough, and adjusts
With all property of medicine；Can also invigorate the spleen and benefit qi, expelling phlegm and arresting coughing, relieving spasm to stop pain.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, cough phlegm
Many, gastral cavity abdomen and four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Safflower：It is warm in nature, taste is pungent, invigorate blood circulation, blood stasis removing analgesic, for Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, bruise
Damage.
Radix Isatidis：Property it is bitter, tremble with fear, the thoughts of returning home, stomach.Function is clearing heat and detoxicating, cool blood relieving sore-throat.Cure mainly influenza, epidemic meningitis, encephalitis,
Pneumonia, erysipelas, heat toxin hair spot, coma hematemesis, pharynx swelling, mumps, pinkeye, sore rash, tongue dark reddish purple dark, larynx numbness, scarlet fever, infection with swollen head
Epidemic disease, carbuncle swells；Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
False pineapple：Can clearing heat and detoxicating, inducing diuresis to remove edema.Kidney stone is cured mainly, urinary tract infections, nephritic dropsy, hyperpyrexia of catching a cold is coughed
Cough, hepatitis, orchitis etc., can also control rheumatalgia, dysentery, stomachache.
In the present invention, 1, dodecyl benzyl dimethyl ammonium chloride, DDAC, diformazan alkyl amine-oxides
Mixed good anti-bacterial effect, the antibiotic rate of cationic antibacterial agent existed in 1 minute to bone marrow poliomyelitis virus sterilizing logarithm value
More than 4；
2nd, cationic antibacterial agent combination L-Epicatechin gallate, antibiotic rate is significantly improved, and 0.5 minute antibiotic rate can be with
Up to 100%.
Specific embodiment
The present invention is made with reference to specific embodiment further explain.
Embodiment 1
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, by mass percentage part, including cation
Antiseptic 0.1%, L-Epicatechin gallate 1.2%, honeysuckle flower 2.0%, the radix paeoniae rubrathe 4.0%, Radix Glycyrrhizae 2.5%, safflower 2.5%,
Radix Isatidis 3.5%, false pineapple 3.5%, ethanol 2.0%, peppermint 0.6%, 100% is complemented to purified water.
Wherein, cationic antibacterial agent is dodecyl benzyl dimethyl ammonium chloride, DDAC, bismethane
Base amine-oxides are mixed to get according to 3: 2: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including
Following steps：
1) honeysuckle flower, the radix paeoniae rubrathe, Radix Glycyrrhizae, safflower, Radix Isatidis, the raw material of false pineapple are weighed in proportion；
2) by step 1) raw material drying, fine powder is ground into, sieve, sterilized under uviol lamp, it is standby；
3) by step 2) sterilized raw material are added to the water, and it is secondary to add water to cook extraction, adds water for the first time 10 times and measures,
Decoct 2 hours, leach liquid, the dregs of a decoction continue to add water 10 times and measure, decoct 2 hours, leach liquid, the dregs of a decoction are discarded, filtrate merges；
4) in step 3) add L-Epicatechin gallate and peppermint in the solution that obtains, be sufficiently stirred for, after be concentrated into
Relative density is determined as 1.10 for 65 DEG C in temperature, obtains aqueous solvent, cooling；
5) ethanol is added to step 4) in the solution that obtains, and stirring dissolves it；
6) in step 5) add cationic antibacterial agent and purified water in the solution that obtains, cationic antibacterial agent and purified water with
Slow way is added and ceaselessly stirred, and it is fully dissolved, and obtains product.
Embodiment 2
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, by mass percentage part, including cation
Antiseptic 0.2%, L-Epicatechin gallate 2.0%, honeysuckle flower 1.2%, radix paeoniae rubrathe 2.0-4.0%, Radix Glycyrrhizae 2.5%, safflower
2.5%th, Radix Isatidis 3.5%, false pineapple 2.5%, ethanol 5.0%, peppermint 1.0%, 100% is complemented to purified water.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC,
Diformazan alkyl amine-oxides are mixed to get according to 4: 2: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including
Following steps：
Step is with embodiment 1, and different specific preparation method parameters is as follows：
First time decocting time 3 hours, second decoction 3 hours；
Relative density is concentrated into temperature for 70 DEG C are determined as 1.15.
Embodiment 3
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, part is anti-including cation by mass percentage
Microbial inoculum 0.15%, L-Epicatechin gallate 1.6%, honeysuckle flower 1.8%, the radix paeoniae rubrathe 3.0%, Radix Glycyrrhizae 2.0%, safflower 3.0%, plate
Blue root 4.2%, false pineapple 3.0%, ethanol 4.0%, peppermint 0.8%, 100% is complemented to purified water.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC,
Diformazan alkyl amine-oxides are mixed to get according to 5: 3: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including
Following steps：
Step is with embodiment 1, and different specific preparation method parameters is as follows：
First time decocting time 2.5 hours, second decoction 2.5 hours；
Relative density is concentrated into temperature for 68 DEG C are determined as 1.13.
Embodiment 4
A kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, by mass percentage part, including cation
Antiseptic 0.2%, L-Epicatechin gallate 1.4%, honeysuckle flower 1.8%, the radix paeoniae rubrathe 4.0%, Radix Glycyrrhizae 2.2%, safflower 3.5%,
Radix Isatidis 4.0%, false pineapple 3.0%, ethanol 3.0%, peppermint 0.8%, 100% is complemented to purified water.
Preferably, the cationic antibacterial agent be dodecyl benzyl dimethyl ammonium chloride, DDAC,
Diformazan alkyl amine-oxides are mixed to get according to 4: 3: 1 ratios.
A kind of preparation method of the environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that including
Following steps：
Step is with embodiment 1, and different specific preparation method parameters is as follows：
First time decocting time 2.8 hours, second decoction 2.3 hours；
Relative density is concentrated into temperature for 66 DEG C are determined as 1.14.
Table 1 is cationic antibacterial agent to bone marrow poliomyelitis virus sterilization effect
Bacterial controls group well-grown.
Conclusion：Under experimental conditions, the disinfectant stock solution, acts on 1min, and the averagely killing to bone marrow poliomyelitis virus is right
Numerical value ＞ 4.00 is qualified to sterilize.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technology according to the present invention scheme and its
Inventive concept is subject to equivalent or change, should all be included within the scope of the present invention.
Claims (5)
1. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection, it is characterised in that part, bag by mass percentage
Include cationic antibacterial agent 0.1-0.2%, L-Epicatechin gallate 1.2-2.0%, honeysuckle flower 1.2-2.0%, radix paeoniae rubrathe 2.0-
4.0%th, ethanol 2.0-5.0%, peppermint 0.6-1.0%, 100% is complemented to purified water.
2. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection according to claim 1, its feature exists
In also including Radix Glycyrrhizae 1.8-2.5%, safflower 2.5-4.0%.
3. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection according to claim 1, its feature exists
In also including Radix Isatidis 3.5-4.8%, false pineapple 2.5-3.5%.
4. a kind of environment-friendly type antibiotic inactivator for treating human papilloma virus infection according to claim 1, its feature exists
In the cationic antibacterial agent is dodecyl benzyl dimethyl ammonium chloride, DDAC, the oxidation of diformazan alkyl
Ammonium is according to 3-5: 2-3: 1 ratio is mixed to get.
5. according to a kind of system of any described environment-friendly type antibiotic inactivators for treating human papilloma virus infection of claim 1-3
Preparation Method, it is characterised in that comprise the following steps：
1) honeysuckle flower, the radix paeoniae rubrathe, Radix Glycyrrhizae, safflower, Radix Isatidis, the raw material of false pineapple are weighed in proportion；
2) by step 1) raw material drying, fine powder is ground into, sieve, sterilized under uviol lamp, it is standby；
3) by step 2) sterilized raw material are added to the water, and it is secondary to add water to cook extraction, adds water for the first time 10 times and measures, and decocts
2-3 hours, liquid is leached, the dregs of a decoction continue to add water 10 times and measure, decocted 2-3 hours, leach liquid, the dregs of a decoction are discarded, filtrate merges；
4) in step 3) add L-Epicatechin gallate and peppermint in the solution that obtains, be sufficiently stirred for, after be concentrated into it is relative
Density is determined as 1.10~1.15 for 65-70 DEG C in temperature, obtains aqueous solvent, cooling；
5) ethanol is added to step 4) in the solution that obtains, and stirring dissolves it；
6) in step 5) cationic antibacterial agent and purified water are added in the solution that obtains, cationic antibacterial agent and purified water are with slow
Mode add and ceaselessly stir, it is fully dissolved, obtain product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108902207A (en) * | 2018-06-04 | 2018-11-30 | 江苏医药职业学院 | A kind of human papilloma virus inactivator and preparation method thereof |
| CN110613778A (en) * | 2019-10-25 | 2019-12-27 | 南京特纳斯生物技术开发有限公司 | Medicament for controlling HPV infection recurrence and preparation method thereof |
| CN110664991A (en) * | 2019-10-25 | 2020-01-10 | 南京特纳斯生物技术开发有限公司 | Medicine for treating wart caused by HPV infection and preparation method thereof |
| CN113813287A (en) * | 2021-08-27 | 2021-12-21 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | Preparation method of compound medicinal liquid for treating verruca vulgaris |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108902207A (en) * | 2018-06-04 | 2018-11-30 | 江苏医药职业学院 | A kind of human papilloma virus inactivator and preparation method thereof |
| CN110613778A (en) * | 2019-10-25 | 2019-12-27 | 南京特纳斯生物技术开发有限公司 | Medicament for controlling HPV infection recurrence and preparation method thereof |
| CN110664991A (en) * | 2019-10-25 | 2020-01-10 | 南京特纳斯生物技术开发有限公司 | Medicine for treating wart caused by HPV infection and preparation method thereof |
| CN113813287A (en) * | 2021-08-27 | 2021-12-21 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | Preparation method of compound medicinal liquid for treating verruca vulgaris |
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