CN106806251A - A kind of degerming oil-control shampoo of balsam pear/green tea and preparation method thereof - Google Patents
A kind of degerming oil-control shampoo of balsam pear/green tea and preparation method thereof Download PDFInfo
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- CN106806251A CN106806251A CN201610934397.0A CN201610934397A CN106806251A CN 106806251 A CN106806251 A CN 106806251A CN 201610934397 A CN201610934397 A CN 201610934397A CN 106806251 A CN106806251 A CN 106806251A
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention discloses degerming oil-control shampoo of a kind of balsam pear/green tea and preparation method thereof, percentage proportioning is as follows：Broad-spectrum antibacterial degreaser 2.0 4.0%；APG 8.0 14.0%；Cocoamidopropyl betaine .0 10.0%；Cocoanut fatty acid diethanolamide 6.0 10.0%；Sodium lauryl sulphate 0.5 2.0%；Vaseline 1.0 1.5%；Polyethylene glycol stearate diester 1.0 1.5%；Essence 0-5.0%；Remainder is deionized water.The degerming oil-control shampoo of balsam pear/green tea of the invention, with antipruritic and anti-dandruff effect, also with to hair and hair be non-stimulated, free from corrosion advantage.
Description
Technical field
The present invention relates to shampoo, more particularly to a kind of degerming oil-control shampoo of balsam pear-green tea and preparation method thereof.
Background technology
Hair hair oil, scalp itch, turn around scurf, and these are many because bacterium grows and causes in head, according to individual
Body difference is different with the species of bacterial infection, is divided into：
1st, seborrhea：Seborrhea is to trigger the topmost reason of dandruff.Occur frequently in Adult Groups, show
To there is thicker oiliness secretion or hair drying on scalp.
2nd, favus of the scalp：It is general in chunk shape and it is tighter be attached on scalp, be often distributed in plaque-like, the surface covering scales of skin that peel off.
3rd, chronic eczema：The germ infection for having scalp and hair causes, and shows as dandruff and hair bifurcated, is broken.Can when serious
With inflammatory reaction.
4th, atopic dermatitis：Show as the dry bits of scalp diffusivity.
After above-mentioned symptom occurs in scalp, if being not added with preventing and treating, after scalp colony balance is destroyed, cause fat metabolic
It is unbalance, the aggravation of symptom is further resulted in, the health status of scalp is destroyed, make diseased region hair be difficult to grow.For this kind of
The treatment of situation, while oil removing carried out to head cleaning, in addition it is also necessary to which it is degerming to carry out deep layer oil-control to scalp and lesion hair follicle,
Fundamentally treat hair, the scalp problems because bacteria breed causes.
The content of the invention
It is an object of the present invention to provide a kind of with the degerming oil-control hair washing of antipruritic and anti-dandruff function balsam pear-green tea
Water.
A kind of degerming oil-control shampoo of balsam pear-green tea, it is characterised in that percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 2.0-4.0%；
APG 8.0-14.0%；
Cocoamidopropyl betaine 7.0-10.0%；
Cocoanut fatty acid diethanolamide 6.0-10.0%；
Sodium lauryl sulphate 0.5-2.0%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.0-1.5%；
Polyethylene glycol stearate diester 1.0-1.5%；
Essence 0-5.0%；
Remainder is deionized water；
Wherein, described broad-spectrum antibacterial degreaser percentage proportioning is as follows：
Fluticasone 1.0 ~ 2.0%；
Cation polyquaternium 2.0 ~ 4.0%；
Balsam pear-green-tea extract 6.0 ~ 8.0%；
Lanolin 1.5 ~ 3.5%；
Deionized water 82.5 ~ 89.5%.
The degerming oil-control shampoo of balsam pear-green tea as claimed in claim 1, it is characterised in that percentage is matched somebody with somebody
Than as follows：
Broad-spectrum antibacterial degreaser 2.5-3.5%；
APG 9.0-13.0%；
Cocoamidopropyl betaine 8.0-9.0%；
Cocoanut fatty acid diethanolamide 7.0-9.0%；
Sodium lauryl sulphate 1.0-1.5%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.1-1.4%；
Polyethylene glycol stearate diester 1.1-1.4%；
Essence 0.5-2.0%；
Remainder is deionized water.
Further, it is that this product is reconciled with the fragrance of essence, the essence is that can use banksia rose class essence.
Preparation method another object of the present invention is to provide the degerming oil-control shampoo of the balsam pear-green tea, it include with
Lower step：
Step（1）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 40-65 DEG C of deionized water
Under carry out emulsifying to obtain mixed liquid B；
Step（2）：After being cooled to 30-35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing is equal
It is even to obtain the degerming oil-control shampoo of institute's balsam pear-green tea.
Further, the step of preparation method of the balsam pear-green tea degerming oil-control shampoo（1）In, the deionized water
Temperature be 45-55 DEG C, emulsification times are carried out under stirring condition for 15-25 minutes.
Further, the step of preparation method of the balsam pear-green tea degerming oil-control shampoo（2）In, stirring mixing when
Between be 3-7 minutes.
Further, in the preparation method of the degerming oil-control shampoo of balsam pear-green tea, its broad-spectrum antibacterial degreaser can by with
Lower step is made：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and in 75-80
Constant temperature flows back 10-15 hours at DEG C, insoluble matter is filtered off after cooling, and be concentrated into 10% ~ 15% by way of vacuum distillation is concentrated；
Powdered balsam pear-green-tea extract is obtained by way of freeze-drying process；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 40-55 DEG C of deionized water, stirred
After mixing mixing 10 ~ 20 minutes, it is cooled to after 30-35 DEG C and adds the balsam pear-green-tea extract of proportional quantity, stirring mixing 3 ~ 7 minutes
Afterwards, mixed liquor A is obtained；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, be well mixed to obtain the broad-spectrum antibacterial degreaser.
Further, the procedure of processing of the broad-spectrum antibacterial degreaser（3）In, the wool of proportional quantity will be added in mixed liquor A
Described broad-spectrum antibacterial degreaser is obtained after being well mixed by emulsification after fat.
The degerming oil-control shampoo of balsam pear-green tea of the invention, in its broad-spectrum antibacterial degreaser, balsam pear-green-tea extract can releive
Skin of head, alleviates head trace and itches, it is to avoid scratching to grab because of capital pruritus causes diseased region to aggravate, and with certain anti-inflammatory work(
Effect, under the complex role of antiseptic fluticasone and cation polyquaternium, with it is good to gram-positive bacteria and
The fungicidal effectiveness of Gram-negative bacteria.The bacterium of deep layer in hair follicle can be killed under the good transdermal effect of fluticasone
Go out, and suppress the accumulation of the macrophage and leucocyte of inflammation part, accelerate the recovery of the inflammation parts such as seborrhea；For
Excessive fat secretion, in the presence of cation polyquaternium, can always cell oil secretion, it is to avoid fat secretion mistake
Cause the deterioration once again of scalp environment more, make germ be difficult to be grown in scalp surface；
The preparation method of the degerming oil-control shampoo of balsam pear-green tea of the invention, the order by merging of each material and mixing condition are more
Rationally so that well mixed by the degerming oil-control shampoo each component of balsam pear-green tea obtained in preparation method of the invention, possess
Good stability.
Specific embodiment
Embodiment 1
The degerming oil-control shampoo of balsam pear-green tea of the present embodiment, percentage proportioning is as follows：Broad-spectrum antibacterial degreaser
2.0-4.0%；
APG 8.0-14.0%；
Cocoamidopropyl betaine 7.0-10.0%；
Cocoanut fatty acid diethanolamide 6.0-10.0%；
Sodium lauryl sulphate 0.5-2.0%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.0-1.5%；
Polyethylene glycol stearate diester 1.0-1.5%；
Essence 0-5.0%；
Remainder is deionized water.
The degerming oil-control shampoo of balsam pear-green tea of the present embodiment, due to containing broad-spectrum antibacterial degreaser composition, therefore, make
With rear, can be effectively degerming, and then with antipruritic and anti-dandruff effect, and due to the degerming oil-control hair washing of the balsam pear-green tea
The each component of water is nontoxic to skin, non-stimulated, free from corrosion material, thus the shampoo also have to hair and hair without
Stimulation, free from corrosion advantage.
In the present embodiment, in order to obtain more preferable antipruritic and antidandruff efficacy, the degerming oil-control hair washing of described balsam pear-green tea
Water, percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 2.5-3.5%；
APG 9.0-13.0%；
Cocoamidopropyl betaine 8.0-9.0%；
Cocoanut fatty acid diethanolamide 7.0-9.0%；
Sodium lauryl sulphate 1.0-1.5%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.1-1.4%；
Polyethylene glycol stearate diester 1.1-1.4%；
Essence 0.5-2.0%；
Remainder is deionized water.
In the present embodiment, in order to obtain more preferable antipruritic and antidandruff efficacy, it is preferred that described broad-spectrum antibacterial degreaser
Percentage proportioning is as follows：
Fluticasone 1.0 ~ 2.0%；
Cation polyquaternium 2.0 ~ 4.0%；
Balsam pear-green-tea extract 6.0 ~ 8.0%；
Lanolin 1.5 ~ 3.5%；
Deionized water 82.5 ~ 89.5%.
In the present embodiment, it is preferred that the essence is bamboo perfume class essence, using bamboo essence can with the balsam pear in product-
Green-tea extract extract component preferably coordinates.
The following is broad-spectrum antibacterial degreaser procedure of processing：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and in 75-80
Constant temperature flows back 10-15 hours at DEG C, insoluble matter is filtered off after cooling, and be concentrated into 10% ~ 15% by way of vacuum distillation is concentrated；
Powdered balsam pear-green-tea extract is obtained by way of freeze-drying process；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 40-55 DEG C of deionized water, stirred
After mixing mixing 10 ~ 20 minutes, it is cooled to after 30-35 DEG C and adds the balsam pear-green-tea extract of proportional quantity, stirring mixing 3 ~ 7 minutes
Afterwards, mixed liquor A is obtained；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, be well mixed to obtain the broad-spectrum antibacterial degreaser.
The following is the procedure of processing of the degerming oil-control shampoo of the balsam pear-green tea：
Step（1）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 40-65 DEG C of deionized water
Under carry out emulsifying to obtain mixed liquid B；
Step（2）：After being cooled to 30-35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing is equal
It is even to obtain the degerming oil-control shampoo of institute's balsam pear-green tea.
Embodiment 2
A kind of preparation method of the degerming oil-control shampoo of balsam pear-green tea for described in embodiment 1 is present embodiments provided, is wrapped
Include following steps：
Step（1）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 40-55 DEG C of deionized water
Under carry out emulsification 15-25 minutes, obtain mixed liquid B；
Step（2）：After being cooled to 30-35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing 3-7
Minute obtains the degerming oil-control shampoo of institute's balsam pear-green tea.
Additionally, in order to make each component of broad-spectrum antibacterial degreaser in this product more powerful, and the stability between each component
It is stronger, it is easy to preservation, broad-spectrum antibacterial degreaser can be prepared by following steps：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and in 75-80
Constant temperature flows back 10-15 hours at DEG C, insoluble matter is filtered off after cooling, and be concentrated into 10% ~ 15% by way of vacuum distillation is concentrated；
Powdered balsam pear-green-tea extract is obtained by way of freeze-drying process；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 40-55 DEG C of deionized water, stirred
After mixing mixing 10 ~ 20 minutes, it is cooled to after 30-35 DEG C and adds the balsam pear-green-tea extract of proportional quantity, stirring mixing 3 ~ 7 minutes
Afterwards, mixed liquor A is obtained；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, be well mixed to obtain the broad-spectrum antibacterial degreaser, more effectively
Ground, by way of emulsification, is well mixed, the stability of obtained broad-spectrum antibacterial degreaser to mixed liquor A and lanolin
More preferably.
Embodiment 3
The present embodiment provides a kind of degerming oil-control shampoo of balsam pear-green tea, and percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 4.0%；
APG 14.0%；
Cocoamidopropyl betaine 10.0%；
Cocoanut fatty acid diethanolamide 10.0%；
Sodium lauryl sulphate 2.0%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.5%；
Polyethylene glycol stearate diester 1.5%；
Essence 5.0%；
Remainder is deionized water.
Broad-spectrum antibacterial degreaser percentage in the present embodiment matches and is：Fluticasone 1.0%；Cation gathers
Quaternary ammonium salt 2.0%；Balsam pear-green-tea extract 6.0%；Lanolin 1.5%；Deionized water 89.5%.
The preparation method of the degerming oil-control shampoo of balsam pear-green tea of the present embodiment is carried out as follows：
Step（1）：Broad-spectrum antibacterial degreaser each component is mixed, broad-spectrum antibacterial degreaser is obtained；
Step（2）：In proportion to the material in addition to broad-spectrum antibacterial oil resistance agent is added in 60 DEG C of deionized water, enter under stirring condition
Row emulsification 18 minutes, obtains mixed liquid B；
Step（3）：After being cooled to 35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, it is uniformly mixed
The degerming oil-control shampoo of institute's balsam pear-green tea.
Through experiment, the degerming oil-control shampoo of balsam pear-green tea of the present embodiment can be effectively antipruritic, anti-dandruff, and uses
Afterwards, non-stimulated to head, corrosion-free, hair is submissiveer.
Embodiment 4
The present embodiment provides a kind of degerming oil-control shampoo of balsam pear-green tea, and percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 2.0%；
APG 8.0%；
Cocoamidopropyl betaine 7.0%；
Cocoanut fatty acid diethanolamide 6.0%；
Sodium lauryl sulphate 0.5%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.0%；
Polyethylene glycol stearate diester 1.0%；
Remainder is deionized water.
Broad-spectrum antibacterial degreaser percentage in the present embodiment matches and is：Fluticasone 2.0%；Cation gathers
Quaternary ammonium salt 4.0%；Balsam pear-green-tea extract 8.0%；Lanolin 3.5%；Deionized water 82.5%.
The preparation method of the degerming oil-control shampoo of balsam pear-green tea of the present embodiment is carried out as follows：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and at 75 DEG C
Lower constant temperature flows back 10 hours, insoluble matter is filtered off after cooling, and be concentrated into 10% by way of vacuum distillation is concentrated；By freezing
The mode of dried process obtains powdered balsam pear-green-tea extract；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 50 DEG C of deionized waters, it is stirred mixed
After closing 15 minutes, it is cooled to after 35 DEG C and adds the balsam pear-green-tea extract of proportional quantity, after stirring mixes 4 minutes, obtains mixed liquor
A；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, be well mixed to obtain the broad-spectrum antibacterial degreaser.
Step（4）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 45 DEG C of deionized water
Under carry out emulsification 18 minutes, obtain mixed liquid B；
Step（5）：After being cooled to 35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing 3 minutes
Obtain the degerming oil-control shampoo of institute's balsam pear-green tea.
Through experiment, the degerming oil-control shampoo of balsam pear-green tea of the present embodiment can be effectively antipruritic, anti-dandruff, and uses
Afterwards, non-stimulated to head, corrosion-free, hair is submissiveer, and relative to embodiment 3, under the conditions of equal medicine drug effect, this product can subtract
The use of few broad-spectrum antibacterial degreaser.
Embodiment 5
The present embodiment provides a kind of degerming oil-control shampoo of balsam pear-green tea, and percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 3.5%；
APG 13.0%；
Cocoamidopropyl betaine 9.0%；
Cocoanut fatty acid diethanolamide 9.0%；
Sodium lauryl sulphate 1.5%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.4%；
Polyethylene glycol stearate diester 1.4%；
Essence 2.0%；
Remainder is deionized water.
Broad-spectrum antibacterial degreaser percentage in the present embodiment matches and is：Fluticasone 1.5%；Cation gathers
Quaternary ammonium salt 3.0%；Balsam pear-green-tea extract 7.0%；Lanolin 2.0%；Deionized water 86.5%.
The preparation method of the degerming oil-control shampoo of balsam pear-green tea of the present embodiment is carried out as follows：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and at 75 DEG C
Lower constant temperature flows back 10 hours, insoluble matter is filtered off after cooling, and be concentrated into 15% by way of vacuum distillation is concentrated；By freezing
The mode of dried process obtains powdered balsam pear-green-tea extract；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 55 DEG C of deionized waters, it is stirred mixed
After closing 15 minutes, it is cooled to after 30 DEG C and adds the balsam pear-green-tea extract of proportional quantity, after stirring mixes 4 minutes, obtains mixed liquor
A；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, be well mixed to obtain the broad-spectrum antibacterial degreaser.
Step（4）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 45 DEG C of deionized water
Under carry out emulsification 18 minutes, obtain mixed liquid B；
Step（5）：After being cooled to 30 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing 3 minutes
Obtain the degerming oil-control shampoo of institute's balsam pear-green tea.
Through experiment, the degerming oil-control shampoo of balsam pear-green tea of the present embodiment can be effectively antipruritic, anti-dandruff, and uses
Afterwards, non-stimulated to head, corrosion-free, hair is submissiveer, relative to embodiment 4, while improving production efficiency, with more
It is effective degerming antibacterial ability, and it is stronger for the antipruritic ability of skin.
Embodiment 6
The present embodiment provides a kind of degerming oil-control shampoo of balsam pear-green tea, and percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 3.2%；
APG 9.0%；
Cocoamidopropyl betaine 8.0%；
Cocoanut fatty acid diethanolamide 7.0%；
Sodium lauryl sulphate 1.0%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.1%；
Polyethylene glycol stearate diester 1.1%；
Essence 0.5%；
Remainder is deionized water.
Broad-spectrum antibacterial degreaser percentage in the present embodiment matches and is：Fluticasone 1.5%；Cation gathers
Quaternary ammonium salt 3.0%；Balsam pear-green-tea extract 7.0%；Lanolin 2.0%；Deionized water 86.5%.
The preparation method of the degerming oil-control shampoo of balsam pear-green tea of the present embodiment is carried out as follows：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and at 75 DEG C
Lower constant temperature flows back 12 hours, insoluble matter is filtered off after cooling, and be concentrated into 15% by way of vacuum distillation is concentrated；By freezing
The mode of dried process obtains powdered balsam pear-green-tea extract；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 55 DEG C of deionized waters, it is stirred mixed
After closing 15 minutes, it is cooled to after 30 DEG C and adds the balsam pear-green-tea extract of proportional quantity, after stirring mixes 4 minutes, obtains mixed liquor
A；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, the wide spectrum suppression will be well mixed to obtain by way of emulsification
Bacterium degreaser.
Step（4）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 45 DEG C of deionized water
Under carry out emulsification 18 minutes, obtain mixed liquid B；
Step（5）：After being cooled to 35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing 3 minutes
Obtain the degerming oil-control shampoo of institute's balsam pear-green tea.
Through experiment, the degerming oil-control shampoo of balsam pear-green tea of the present embodiment can be effectively antipruritic, anti-dandruff, and uses
Afterwards, non-stimulated to head, corrosion-free, hair is submissiveer, more excellent relative to product drug effect in embodiment 3, and relative to reality
Apply in example 5, possess more longlasting preservation term.
Pharmacodynamics research of the present invention：
First, of the invention antipruritic and antibacterial action is verified in terms of zoopery：
1 material
1.1 animals
Mouse, regular grade, male and female half and half, body weight 18-22g, rat, male, body weight 180-220g.
1.2 medicines and reagent
Modeling reagent：Depilatory cream：Carrageenan：Histamine phosphate；Dimethylbenzene.
Use medicine：Shampoo in embodiment 6
Key instrument
Electronic balance, electric heating constant temperature deionized water bath, vola pedis capacity measurer
2 methods and result
2.1 itching-relieving actions：
Take mouse 20 and be only randomly divided into two groups, every group 10, male and female half and half, respectively control group, test group.24h before experiment, gives
Instep shaving behind each group cavy right side, is smeared 1 time, every time 5 seconds with cotton swab.On the experiment same day, right metapedes shaving is abraded with coarse sandpaper
Place, area 1c ㎡.Local cotton swab is smeared 1 time, 5 seconds 1 time every time, starts to drip 0.01% phosphoric acid tissue at the surface of a wound after 10min
Only, hereafter every 3min0.02%, 0.03% ... progressive concentration is 0.05ml/ only to amine 0.05ml/ every time.Until cavy is turned one's head
Lick the histamine phosphate's total amount given during right metapedes（μg）It is itch-threshold.Record and compare the itch-threshold of each group.Result shows：
Dehumidifying itching-relieving gels group itch-threshold（321±350.8）μ g, with matrix group（55±47.2）μ g compare, P ＜ 0.01.It can be seen that
Invention product plays the role of significantly to resist itch caused by histamine phosphate.
2.2 bacteriostasis
Carry out external susceptibility MIC experiments：
Test strain：Fungi, Candida albicans, staphylococcus aureus, enteropathogenic E. Coli.
Method：Each test strain is made bacteria suspension of physiology salt deionized water, and is diluted to turbidity for more than 2.0McF
Bacteria suspension, then 100 times are diluted with physiology salt deionized water, RPMII640 dilutes 10 times, test group（In the embodiment of the present invention 5
Shampoo）And control group（Health king's washing lotion）Doubling dilution, 72-96h is cultivated in 96 well culture plates, slight concussion, is carried out at 490nm
Photoelectric colorimetry.
Table 1
2.3 conclusions
Referring to table 1, the present invention has the inhibitory action of highly significant to the guinea pig skin itch experiment caused by histamine phosphate（P ＜
0.05 or P ＜ 0.01）；Had a look at out by external susceptibility MIC experiments：The present invention is to fungi, Candida albicans, golden yellow grape
Coccus, enteropathogenic E. Coli have stronger antibacterial action.
Experiment above shows：Effect of the present invention with antipruritic antibacterial, therefore, each microbial dandruff also has to more than
The effect for removing.
Major Clinical research of the present invention：
Convene skin of head trace occur to itch, fall bits, each 60 of the men and women volunteer with slight seborrhea, be divided into 4 groups,
Every group of each 15 people of men and women, tests the shampoo in this product embodiment 3-6, test mode be per once two days, when it is a length of
20 days, it was that itch situation, dandruff of volunteer's head treats situation, and scalp inflammation site treatment situation to investigate object.
The results are shown in Table 2, it is seen that the degerming oil-control shampoo of balsam pear-green tea of the invention has antipruritic, anti-dandruff effect, and
And it is non-stimulated to scalp, corrosion-free, it is submissive using rear hair.
Table 2
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although reference
Previous embodiment has been described in detail to the present invention, it will be understood by those within the art that：It still can be right
Technical scheme described in foregoing embodiments is modified, or carries out equivalent to which part technical characteristic；And this
A little modifications are replaced, and do not make the spirit and model of the essence disengaging various embodiments of the present invention technical scheme of appropriate technical solution
Enclose.
Claims (8)
1. the degerming oil-control shampoo of a kind of balsam pear-green tea, it is characterised in that percentage proportioning is as follows：
Broad-spectrum antibacterial degreaser 2.0-4.0%；
APG 8.0-14.0%；
Cocoamidopropyl betaine 7.0-10.0%；
Cocoanut fatty acid diethanolamide 6.0-10.0%；
Sodium lauryl sulphate 0.5-2.0%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.0-1.5%；
Polyethylene glycol stearate diester 1.0-1.5%；
Essence 0-5.0%；
Remainder is deionized water；
Wherein, described broad-spectrum antibacterial degreaser percentage proportioning is as follows：
Fluticasone 1.0 ~ 2.0%；
Cation polyquaternium 2.0 ~ 4.0%；
Balsam pear-green-tea extract 6.0 ~ 8.0%；
Lanolin 1.5 ~ 3.5%；
Deionized water 82.5 ~ 89.5%.
2. the degerming oil-control shampoo of balsam pear-green tea as claimed in claim 1, it is characterised in that percentage is matched
It is as follows：
Broad-spectrum antibacterial degreaser 2.5-3.5%；
APG 9.0-13.0%；
Cocoamidopropyl betaine 8.0-9.0%；
Cocoanut fatty acid diethanolamide 7.0-9.0%；
Sodium lauryl sulphate 1.0-1.5%；
Fat alcohol polyethylene ether sodium sulphate 1.5-2.5%；
Vaseline 1.1-1.4%；
Polyethylene glycol stearate diester 1.1-1.4%；
Essence 0.5-2.0%；
Remainder is deionized water.
3. the degerming oil-control shampoo of balsam pear-green tea as claimed in claim 1 or 2, it is characterised in that the essence is banksia rose class
Essence.
4. the preparation method of the degerming oil-control shampoo of balsam pear-green tea as described in claim any one of 1-3, it is characterised in that
Comprise the following steps：
Step（1）：In proportion to adding the material in addition to broad-spectrum antibacterial oil resistance agent, stirring condition in 40-65 DEG C of deionized water
Under carry out emulsifying to obtain mixed liquid B；
Step（2）：After being cooled to 30-35 DEG C, to the broad-spectrum antibacterial degreaser that proportional quantity is added in mixed liquid B, stirring mixing is equal
It is even to obtain the degerming oil-control shampoo of institute's balsam pear-green tea.
5. the preparation method of the degerming oil-control shampoo of balsam pear-green tea as claimed in claim 4, it is characterised in that：The step
（1）In, the temperature of the deionized water is 45-55 DEG C, and emulsification times are carried out under stirring condition for 15-25 minutes.
6. the preparation method of the degerming oil-control shampoo of balsam pear-green tea as claimed in claim 4, it is characterised in that：The step
（2）In, the time for stirring mixing is 3-7 minutes.
7. the preparation method of the degerming oil-control shampoo of balsam pear-green tea as described in any one of claim 4, it is characterised in that bag
Include following steps：
Step（1）：After balsam pear and green tea are filtered using petroleum ether degreasing, 75% ethanol solution is added thereto to and in 75-80
Constant temperature flows back 10-15 hours at DEG C, insoluble matter is filtered off after cooling, and be concentrated into 10% ~ 15% by way of vacuum distillation is concentrated；
Powdered balsam pear-green-tea extract is obtained by way of freeze-drying process；
Step（2）：To fluticasone and cation polyquaternium that proportional quantity is added in 40-55 DEG C of deionized water, stirred
After mixing mixing 10 ~ 20 minutes, it is cooled to after 30-35 DEG C and adds the balsam pear-green-tea extract of proportional quantity, stirring mixing 3 ~ 7 minutes
Afterwards, mixed liquor A is obtained；
Step（3）：The lanolin of proportional quantity will be added in mixed liquor A, be well mixed to obtain the broad-spectrum antibacterial degreaser.
8. the preparation method of the degerming oil-control shampoo of balsam pear-green tea as described in any one of claim 7, it is characterised in that bag
Include following steps：
Described step（3）In, obtain described after being well mixed by emulsification after the lanolin that proportional quantity is added in mixed liquor A
Broad-spectrum antibacterial degreaser.
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Cited By (1)
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| CN112263499A (en) * | 2020-11-27 | 2021-01-26 | 佛山市南海东方澳龙制药有限公司 | Animal shampoo with antibacterial function and preparation method thereof |
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2016
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112263499A (en) * | 2020-11-27 | 2021-01-26 | 佛山市南海东方澳龙制药有限公司 | Animal shampoo with antibacterial function and preparation method thereof |
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