CN106805970A - A kind of multichannel brain functional imaging device and method - Google Patents
A kind of multichannel brain functional imaging device and method Download PDFInfo
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Abstract
The invention discloses a kind of multichannel brain functional imaging device and method, method includes：One or more transmitting antennas and reception antenna are connected according to the instruction selection of central processing unit, launches two-way light quantum；Lead up to transmitting antenna and be transmitted into detected tissue, another road is transmitted directly to light quantum receiver module；Light quantum receiver module receives the light quantum all the way of directly transmitting, and the light quantum that another road is changed by the detected reflection organized, refraction, scattering and photochemical action state, and calculating is analyzed to above-mentioned light quantum state, obtain final detected structural constituent data and be detected the activity of tissue heat and bioelectric data；Central processing unit instruction is performed according to above-mentioned activity data, respective image reconstruction is carried out.The present invention has stronger scan capability, and measurement data is more direct, sensitiveer, and information content is bigger, more stable, non-time delay.
Description
Technical field
The present invention relates to the cerebral function imaging technology in medical science, and in particular to a kind of multichannel brain functional imaging
Device and method.
Background technology
In medical science, visual medical image can help medical worker according to Human physiology and pathology
Learn change and make diagnosis, medical image and its familiar normal picture are carried out Anomalies contrast by medical worker, so as to make just
Make a definite diagnosis disconnected, it is seen that information quality and quantity that medical image is shown are the basis of Image Diagnosis, the informative of image
Degree correctly diagnose particularly significant to making.
Medical image imaging includes X-Ray, ultrasonic wave, CT, MRI, MEG, PET, NIRS etc., typically, medical image imaging
Technology is divided into projection imaging and the class of reestablishment imaging two, and such as fracture X-Ray imagings are directly thrown using tissue is different to X-Ray absorption values
Shadow is imaged, and diagnosis is made according to human dissection, physiology and pathological change；And as " inflammation " etc. is needed in molecular level diagnosis
Disease, then can not show human anatomic structure by photographic means carries out Morphologic Diagnosis, but can be by calculating auxiliary
By sightless information reconstruction into visualization medical image, for example, the gray level image density directly simulate of X-Ray and its changing
Reflect the dissection and pathological change of human tissue structure, but X-Ray images make some tissues or focus projection capped, it is impossible to
It has been shown that, CT rebuilds analog image on the basis of X-Ray by digital conversion, there is provided image resolution ability higher, overcomes
The problem that X-Ray check images are overlapped, improves Lesion Detection rate.
With the development of technology, on the basis of assisted reconstruction imaging is calculated, occurring in that can cannot see morphological examination
The functional imaging technology that the information for observing is showed with image format, such as blood flow to the information with flow velocity；Functional imaging
The defect of technological break-through " morphology " diagnosis, further expands the range of application of imaging technique, at present, the main aspect bag being related to
Neuro-physiology and Neuropsychology are included, the hearts such as Motor cortex and memory such as the sense of hearing, language, cognitive and mood are just gradually being spread over
The research of reason activity.Functional imaging technology is estimated and experimental therapeutic intervention effect for the research of sacred disease, diagnosis, progress
Evaluation, sensitive, objective accurate information evaluation can be provided.Functional imaging for the cranial nerve lesion in neuro-physiology grinds
Study carefully, be related to epilepsy, parkinsonism, Alzheimer disease (AD), multiple cerebral sclerosis (MS) and cerebral infarction wait indefinitely aspect.
FMRI (functional magnetic resonance imaging, fMRI) and feature
Near-infrared spectrum technique (functional near-infrared spectroscopy, fNIRS) contributes to cranial nerve lesion
Functional imaging technology, functional imaging fMRI, fNIRS image not only include anatomic information, and with the anti-of nervous system
Answer mechanism.At present, fNIRS and fMRI are that brain activity is measured using blood flow and blood oxygen change, and difference is that fMRI is utilized
Magnetic battle array contrast imaging, and fNIRS is then changed using hemoglobin in blood vessel for the scattering of near infrared light.
Functional magnetic resonance Brian Imaging (fMRI) technology is high due to the resolution in time, space, early diagnosis, mirror to disease
Not, treatment and more after tracking have great importance, but but there is irremediable defect in fMRI, for example can not to early stage
Gestation, respiratory system patient use, it is impossible to which, to there is ferromagnetism implant patient to use, MRI carries out radiography using Gd contrast medium, right
Renal function has certain influence, and artifact can't be completely eliminated；In addition, fMRI detections blood oxygen change is with electroneurographic signal not
It is synchronous, general 6s more delayed than nervous activity of peak value of blood oxygen signal or so.
Function near infrared spectrum Brian Imaging (fNIRS) technology is a kind of side of dynamic detection brain function that developed recently gets up
Method, with compatible magnetic metal, allows continuous measurement for a long time and in the short time the features such as repeated multiple times measurement；Can be compared with
Accurately to distinguish the signal from different brain structures, its spatial resolution reaches 1-2 millimeters, moreover, the sampling of fNIRS
Rate can reach 0.1 second, significantly larger than functional mri, and the near-infrared spectroscopy technology more generation of disperse optical imagery
The table developing direction of future cognitive Neuscience.Meanwhile, function near infrared spectrum brain imaging technique also has the following disadvantages：
(1) NIRS penetration powers are poor, it is generally recognized that can only penetrate skin 3-8cm；
(2) resolution capabilities of the fNIRS to structural constituent as fMRI technologies is very limited, because its frequency range is narrow, in the light
The spectrum of the spectrum of some molecular level materials and human body other materials has and overlaps in spectral limit, and scan data precision is poor, example
Such as, to glucose detection, although have the analysis information of detection glucose, but optimal spectrum model near infrared spectral range
It is trapped among between 2.0um-2.5um, although the spectrum of glucose is independent, with human body other materials in the spectral region
Spectrum has overlapping, and it is subcutaneous little that this just causes near infrared light to penetrate, the absorptance very little of glucose, on the other hand, although body
Correlation is implicitly present on blood glucose value and the optical signalling surveyed, can provide evidence but without non-invasive experiment proves
The signal surveyed can be associated with actual blood sugar concentration, therefore is difficult to measure glucose by fNIRS；
(3) fNIRS is to calculate brain tissue activity by oxygen consumption as fMRI, and measurement sensitivity is poor, unstable, accurate
Degree is low, and time delay is larger.
The content of the invention
The technical problems to be solved by the invention are that existing cerebral function imaging scan capability is poor, and measurement sensitivity is poor, no
Stabilization, accuracy are low, the larger problem of time delay.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is to provide a kind of multichannel brain functional imaging
Device, including：
Central processing unit, sends light quantum and instruction and gating command occurs；
Light quantum is produced and transmitter module, and the light quantum according to the central processing unit occurs command request, corresponding hair
Raw, transmitting two-way light quantum；
Light quantum receiver module, receives the light quantum all the way that the light quantum is produced and transmitter module is directly sent respectively,
And another road includes transmitting, refraction, scattering, absorption and shape after photochemical action by detected brain tissue and by brain tissue
The light quantum that state and counting change, analyzes state and the counting of light quantum, obtains corresponding analyzable light quantity subdata, heat
Activity data and bioelectric data；
Gating control matrix module, according to the gating command selection of the central processing unit connect the light quantum produce and
One or more light quantum transmitting of transmitter module or the light quantum receiver module or reception antenna；
Computation analysis module, analyzable light quantity subdata, hot activity data and bioelectric data to receiving are entered
Row analytical calculation, the compositional data for obtaining being detected tissue and the final hot activity data and bioelectric that are detected tissue
Data；
Image-forming module, according to the computation analysis module send detected tissue compositional data and be detected tissue
Final heat activity and bioelectric data perform the central processing unit instruction, carry out corresponding visual image reconstruction.
In said apparatus, the light quantum is produced and transmitter module is occurred by light quantum modulation matrix unit, light quantum
Device, light quantum optical splitter, light quantum transmitting antenna matrix are constituted；Wherein,
The light quantum modulation matrix unit is instructed to output light quantum according to the generation that the central processing unit sends
Frequency, power, waveform are modulated coding；The optical quantum generator produces light quantum according to modulated signal；The quantum point
The light quantum that generator is produced is divided into two-way by light device；One or more antennas in the one route light quantum transmitting antenna matrix
Detected brain tissue is transmitted into, another road is directly sent to the light quantum receiver module.
In said apparatus, the light quantum receiver module includes light quantum reception antenna matrix, light quantum state-detection
Unit, light quantum signal amplification unit, light quantity subsignal demodulating and decoding unit, D/A conversion unit and digital filter unit；Its
In,
One or more antennas of the light quantum reception antenna matrix receive directly produced by the light quantum all the way and
The light quantum that transmitter module is launched, and another road is by being detected brain tissue and by brain tissue including reflecting, reflecting, dissipate
Penetrate, absorb and photochemical action after state and the light quantum that changes of counting, and by the light quantum state detection unit pair
Light quantum carries out state-detection, then turns by the light quantum signal amplification unit, light quantity subsignal demodulating and decoding unit, digital-to-analogue
Change unit and cross amplification, demodulating and decoding, digital-to-analogue conversion and the filtering of filter unit, obtain analyzable light quantity subdata, heat living
Dynamic data and biological electricity data.
In said apparatus, the computation analysis module includes light quantum statistical physics computing unit, light quantum energy
Analysis of spectrum statistic unit, light quantum absorption resonance analytic unit and scattering analysis unit, light quantum difference analysis unit and light quantity
Sub- differential doppler analytic unit；
The light quantum absorption resonance analytic unit, scattering analysis unit are using the analyzable heat activity for being detected tissue
The absorption spectrum and scattering spectrum for being detected and organizing to injecting light quantum are calculated with bioelectric data analysis；
The light quantum energy spectrum analysis statistic unit, the light quantity the analyzed subdata to receiving carries out energy spectrum analysis
Calculate；
The light quantum statistical physics computing unit, statistical analysis absorption resonance unit, scattering analysis unit and light
The result of calculation of energy of a quantum analysis of spectrum statistic unit, analysis obtains being detected the compositional data of tissue and is detected tissue finally
Heat activity and bioelectric data；
Light quantum difference analysis unit and light quantum differential doppler analytic unit analytical calculation velocity of blood flow or specific
Component.
In said apparatus, the light quantum is produced and transmitting mould occurs, the light quantum of transmitting includes non-Entangled State light quantity
Son, Entangled State light quantum pair and non-Entangled State light quantum and Entangled State light quantum are to three kinds of situations；
When there was only non-Entangled State light quantum, it is tested that the light quantum produces and launch mould to be transmitted into it all the way
Brain tissue is surveyed, absorption, reflection, refraction and the scattering and photochemical action that are detected brain tissue change the state of light quantum, and
The heat activity and bioelectric that brain tissue is detected under photochemical action change, and receive tested by light quantum receiver module
Survey brain tissue and change the light quantum of state and the hot movable and bioelectric signal of detected brain tissue, and carry out state-detection
And amplification, demodulating and decoding, digital-to-analogue conversion and filtering obtain analyzable light quantity subdata, hot activity data and biological electricity number
According to；Signal is transmitted directly to light quantum receiver module to another non-Entangled State light quantum in road as a comparison, carry out state-detection and
Amplification, demodulating and decoding, digital-to-analogue conversion and filtering, obtain analyzable standard light quantity subdata；The computation analysis module passes through
Carry out comparing calculation to analyzable light quantity subdata and standard light quantity subdata, and to analyzable light quantity subdata, can
The analytical calculation of the hot activity data and biological electricity data of analysis, obtains the compositional data of tested tissue, final hot activity data
With final biological electricity data；
When there was only Entangled State light quantum pair, the light quantum is produced and transmitter module is by Entangled State light quantum pair
In a light quantum be transmitted into detected brain tissue；Another light quantum of Entangled State light quantum centering directly transmits light supply
Sub- receiver module, the light quantum receiver module carries out state to the Entangled State light quantum for being transmitted directly to light quantum receiver module
Detection and amplification, demodulating and decoding, digital-to-analogue conversion and filtering, obtain analyzable light quantity subdata；The computation analysis module
Carry out calculating compositional data, final hot activity data and life that analysis obtains tested tissue by the way that light quantity subdata can be analyzed to this
Thing electricity data；
When non-Entangled State light quantum and Entangled State light quantum pair, light quantum is produced and transmitting mould, light quantum connect
Module and computation analysis module are received according to the above-mentioned processing mode point for only existing non-Entangled State light quantum or Entangled State light quantum pair
Do not processed；The compositional data of computation analysis module tested tissue again to respectively obtaining, final hot activity data
Counted with biological electricity data.
In said apparatus, the optical quantum generator includes producing the multiband pulse light quantity of multiband pulse light quantum
The Entangled State of sub- generating unit, the continuous wave light quantum generating unit of generation continuous wave light quantum and generation Entangled State light quantum pair
Light quantum is to generating unit；
The light quantum reception antenna matrix includes that the multiband pulse light quantum for receiving multiband pulse light quantum is received
The Entangled State light quantum of unit, the continuous wave light quantum receiving unit for receiving continuous wave light quantum and reception Entangled State light quantum connects
Receive unit.
In said apparatus, the light quantum transmitting antenna matrix and the light quantum reception antenna matrix are included solely respectively
Multiple light quantum transmitting antennas and light quantum reception antenna of vertical work；
One or more light quantum transmitting antennas and one or more light quantum reception antennas are according to certain regularly arranged structure
Into the transmitting of reusable light quantum and reception antenna matrix, each light quantum transmitting antenna and light quantum reception antenna have one admittedly
Fixed coding and a three dimensional space coordinate；Antenna in array is by gating control matrix module control gating.
In said apparatus, the also data rectification module including knowledge based storehouse, using the error compensation method in knowledge based storehouse
Amendment data.
Present invention also offers a kind of multichannel brain functional imaging method, comprise the following steps：
Step S10, instruction selection connection light quantum transmitting antenna matrix and corresponding light quantum according to central processing unit
One or more antennas of reception antenna matrix；
Step S20, the command request according to central processing unit, launch two-way light quantum；Lead up to transmitting antenna transmitting
To detected tissue, another road is transmitted directly to light quantum receiver module；
Step S30, light quantum receiver module receive the light quantity all the way that light quantum is produced and transmitter module is directly launched respectively
Son, and another road is turned into by after detected brain tissue and by brain tissue including transmitting, refraction, scattering, absorption and light
With rear state and count the light quantum that changes, analyze state and the counting of light quantum, obtain analyzing light quantity subdata with
And hot activity data and biological electricity data；
Step S40, pair can analyze light quantity subdata and hot activity data and biological electricity data are analyzed calculating, obtain
It is detected structural constituent data and is detected the final heat activity of tissue and bioelectric data；
Step S50, the final heat activity according to the composition and detection tissue for being detected tissue and bioelectric data
Central processing unit instruction is performed, respective image reconstruction is carried out.
In the above-mentioned methods, including detection imaging active work mode and detection imaging passive work mode；Wherein,
Detection is imaged active work mode：Central processing unit sends instruction, by optical quantum generator produce continuous wave spectrum,
The Entangled State light quantum or non-Entangled State light quantum of wave spectrum are fixed in pulse, are launched by antenna emission matrix, via detected
Tissue, is received by light quantum receiver module, then carry out calculating analysis obtain structural constituent and organize final heat activity and
Bioelectric data；
Detection is imaged passive work mode：Central processing unit sends instruction, and tested group is received by light quantum receiver module
Knit because of the infrared signal and electrical activity signal that light quantum scanning is radiated all the way, then carry out calculating analysis acquisition and be organized into
Divide and organize final heat activity and bioelectric data.
The present invention is obtained using the non-Entangled State light quantum of continuous wave spectrum and the Entangled State light quantum of pulse spectrum to characteristic
Tissue ingredient of human body tissue ingredient information, heat activity, bioelectric information and displacement information, and be imaged by area of computer aided；With with
Lower advantage：
(1) using the light quantum of the continuous wave spectrum of multiband, with stronger resolution capability, can analyze many using absorption spectrum
Plant structural constituent；
(2) investigation depth is deeper, and light quantum can not be transmitted or absorbed in reflection, refraction, scattering process, still can
Enough state changes that the light quantum is detected by being in the light quantum of Entangled State with it, restore all of the light quantum state
Information；
(3) direct access structural constituent data, hot activity data and bioelectric data, measurement data is more directly, more
It is sensitive, using more flexible, more stable；
(4) light quantity subsignal does not exist ferromagnetic compatibility issue, it is not necessary to radiography, safety and reliability.
Brief description of the drawings
A kind of structured flowchart of multichannel brain functional imaging device that Fig. 1 is provided for the present invention；
Fig. 2 is the structured flowchart of optical quantum generator in the present invention；
Fig. 3 is the structured flowchart of light quantum receiver module in the present invention；
Fig. 4 is the embodiment schematic diagram of a reusable light quantum transmitting and reception antenna matrix in the present invention；
Fig. 5 for the present invention in reusable light quantum transmitting and reception antenna matrix work in the helmet form when antenna be distributed show
It is intended to；
Fig. 6 is that the light quantum transmitting antenna or light quantum of reusable transmitting and reception antenna matrix in the present invention receive day
Line, while appearing in the operating diagram in several hot-wire arrays；
A kind of flow chart of multichannel brain functional imaging method that Fig. 7 is provided for the present invention；
Fig. 8 is the workflow diagram of detection imaging active work mode in the present invention；
Fig. 9 is the workflow diagram of detection imaging passive work mode in the present invention.
Specific embodiment
Each molecule has a characteristic wave spectrum and optical transmission window, to specific wavelength absorption resonance and scattering refracting characteristic
By the fingerprint as identification material molecule.The present invention is detected tissue using continuous wave spectrum and pulse spectrum scanning, obtains tissue
Constituent, heat activity and the data such as bioelectric, or using impulse wave to particular organization's (such as brain tissue) into
Divide and positioned and measured；Improved from the basic theory of acquisition of information, sufficiently make use of that continuous wave spectrum is non-to be tangled
State light quantum and Photon Quantum Entangled State characteristic.Wherein, Photon Quantum Entangled State characteristic for Entangled State light quantum to A by light quantum A1
And constituted with A2s of the A1 in Entangled State, light quantum A1 state changes necessarily cause the change of another light quantum A2 states,
As long as the light quantum in Entangled State so is transmitted into detected brain tissue to a light quantum A1 in A, light quantum A1 is received
To detected structural constituent influence (such as RESONANCE ABSORPTION, Rayleigh scattering, Raman scattering, refraction, reflection, photochemical action), light quantity
Sub- A1 states and other physical properties change, and are in the shape of the light quantum A2 of Entangled State with light quantum A1 by measurement
State, can just obtain the status data of light quantum A1, so as to obtain being detected the composition organized, the position of detected composition, be detected
Survey the thermodynamic data and bioelectric data of tissue；No longer as fNIRS calculates neuron as fMRI by oxygen consumption
Activity, but direct detection neuron thermodynamics activity data, complete image reconstruction.
The present invention is described in detail with reference to Figure of description and specific embodiment.
As shown in figure 1, a kind of multichannel brain functional imaging device that the present invention is provided, for cerebral function imaging, is organized into
Analysis, volume infarct cerebral and composition positioning, including central processing unit, light quantum are produced and transmitter module, light quantum receive mould
Block, gating control matrix module, computation analysis module and image-forming module.
Central processing unit, sends light quantum and instruction and gating command occurs；
Light quantum is produced and transmitter module, and the light quantum according to central processing unit occurs command request, corresponding to occur, send out
Penetrate two-way light quantum.
In the present invention, light quantum is produced and transmitter module includes light quantum modulation matrix unit, optical quantum generator, light
Quantum optical splitter, light quantum transmitting antenna matrix.Wherein,
Light quantum modulation matrix unit instructs frequency, the work(to exporting light quantum according to the generation that central processing unit sends
Rate, waveform are modulated coding；Optical quantum generator produces light quantum according to modulated signal；Quantum optical splitter produces generator
Light quantum be divided into two-way；One or more antennas are transmitted into detected brain tissue in one route light quantum transmitting antenna matrix,
Another road is directly sent to light quantum receiver module.
Light quantum receiver module, receives the light quantum all the way that light quantum is produced and transmitter module is directly sent respectively, and
Another road is by being detected brain tissue and being included transmitting, refraction, scattering, absorption and state after photochemical action by brain tissue
The light quantum changed with counting, state and counting to light quantum carry out state-detection, obtain corresponding analyzable light quantity
Subdata, hot activity data and biological electricity data.
Light quantum receiver module includes that light quantum reception antenna matrix, light quantum state detection unit, light quantity subsignal are put
Big unit, light quantity subsignal demodulating and decoding unit, D/A conversion unit and digital filter unit.
One or more antennas in light quantum reception antenna matrix are received and directly produced and transmitting mould by light quantum all the way
The light quantum of block transmitting, and another road includes reflection, refraction, scattering, suction by detected brain tissue and by brain tissue
The light quantum changed with state after photochemical action and counting is received, and by light quantum state detection unit to two-way light quantum
State-detection is carried out, then by light quantum signal amplification unit, light quantity subsignal demodulating and decoding unit, D/A conversion unit and mistake
The amplification of filter unit, demodulating and decoding, digital-to-analogue conversion and filtering, obtain being detected analyzable light quantity subdata, the heat of tissue
Activity data and biological electricity data.
Gating control matrix module, according to the gating command selection of the central processing unit connect the light quantum produce and
One or more light quantum transmitting of transmitter module or the light quantum receiver module or reception antenna.
Computation analysis module, analyzable light quantity subdata, hot activity data and biological electricity data to receiving are divided
Analysis is calculated, and is obtained being detected structural constituent data and is detected the final hot activity data and bioelectric data of tissue
Deng.
In the present invention, computation analysis module includes light quantum statistical physics computing unit, light quantum energy spectrum analysis
Statistic unit, light quantum absorption resonance analytic unit and scattering analysis unit (including Raman scattering analytic unit, Rayleigh scattering point
Analysis unit etc.), light quantum difference analysis unit and light quantum differential doppler analytic unit.
Light quantum absorption resonance analytic unit, scattering analysis unit are using the analyzable heat activity and life for being detected tissue
Thing electrical activity data analytical calculation is detected tissue to injecting the absorption spectrum and scattering spectrum of light quantum.
Light quantum energy spectrum analysis statistic unit, the light quantity the analyzed subdata to receiving carries out energy spectrum analysis meter
Calculate.
Light quantum statistical physics computing unit, statistical analysis absorption resonance unit, scattering analysis unit and light quantum
The result of calculation of energy spectrum analysis statistic unit, so as to analyze the compositional data for obtaining being detected tissue and be detected tissue finally
Hot activity data and bioelectric data etc..
Light quantum difference analysis unit and light quantum differential doppler analytic unit analytical calculation velocity of blood flow or specific
The translational speed of component such as lymphocyte, drug ingedient.
Image-forming module, the compositional data of the detected tissue sent according to computation analysis module and to be detected tissue final
Hot activity and bioelectric data etc. perform central processing unit instruction, are accordingly imaged.
Image-forming module includes Data correction module and reestablishment imaging module, detected tissue of the Data correction module to reception
Compositional data and the final heat activity of tissue and bioelectric data be corrected, reestablishment imaging module is processed according to center
Device is instructed, and image weight is carried out using the compositional data of the detected tissue of correction and the activity of tissue heat and bioelectric data
Build.
In the present invention, light quantum is produced and transmitting mould occurs, the light quantum of transmitting includes non-Entangled State light quantum, tangles
State light quantum pair and non-Entangled State light quantum and Entangled State light quantum are to three kinds of situations.
(1) for only having during non-Entangled State light quantum, it is tested that light quantum produces and launch mould to be transmitted into it all the way
Brain tissue is surveyed, absorption, reflection, refraction and the scattering and photochemical action that are detected brain tissue change the state of light quantum, and
The heat activity and bioelectric that brain tissue is detected under photochemical action change, and receive tested by light quantum receiver module
Survey brain tissue and change the light quantum of state and the hot movable and bioelectric signal of detected brain tissue, and carry out state-detection
And amplification, demodulating and decoding, digital-to-analogue conversion and filtering obtain analyzable light quantity subdata, hot activity data and biological electricity number
According to；Signal is transmitted directly to light quantum receiver module to another non-Entangled State light quantum in road as a comparison, carry out state-detection and
Amplification, demodulating and decoding, digital-to-analogue conversion and filtering, obtain analyzable standard light quantity subdata；Computation analysis module is by pair can
The light quantity subdata of analysis and standard light quantity subdata carry out comparing calculation, and to analyzable light quantity subdata, can analyze
Hot activity data and biological electricity data analytical calculation, obtain the compositional data of tested tissue, final hot activity data and
Final biological electricity data etc..
(2) for only having during Entangled State light quantum pair, light quantum is produced and transmitter module is by Entangled State light quantum pair
In a light quantum (being seen as all the way) as probe emission to detected brain tissue；Another light of Entangled State light quantum centering
Quantum (regarding another road as) is transmitted directly to light quantum receiver module as shadow measurement probe, and light quantum receiver module is to direct
Being sent to the Entangled State light quantum of light quantum receiver module carries out state-detection and amplification, demodulating and decoding, digital-to-analogue conversion and filter
Ripple, obtains analyzable light quantity subdata；Computation analysis module carries out calculating by this can analyzing light quantity subdata and analyzes
Compositional data to tested tissue, final hot activity data and biological electricity data etc..
(3) when for non-Entangled State light quantum and Entangled State light quantum pair, light quantum is produced and transmitting mould, light quantum
Receiver module and computation analysis module are according to the above-mentioned processing mode for only existing non-Entangled State light quantum or Entangled State light quantum pair
It is respectively processed；The compositional data of computation analysis module tested tissue again to respectively obtaining, final hot activity data and
Biological electricity data are counted.
In the present invention, as shown in Fig. 2 optical quantum generator includes producing the multiband pulse of multiband pulse light quantum
Light quantum generating unit, the continuous wave light quantum generating unit for producing continuous wave light quantum and generation Entangled State light quantum are to entangling
State light quantum is twined to generating unit.
Accordingly, as shown in figure 3, light quantum receiver module includes receiving the multiband pulsed light of multiband pulse light quantum
The Entangled State of quantum receiving unit, the continuous wave light quantum receiving unit for receiving continuous wave light quantum and reception Entangled State light quantum
Light quantum receiving unit.
In the present invention, light quantum transmitting antenna matrix and light quantum reception antenna matrix include working independently respectively
Multiple light quantum transmitting antennas and light quantum reception antenna；In the present invention, multiple light quantum transmitting antennas can independent structure
Into light quantum transmitting antenna matrix, multiple light quantum reception antennas can be separately formed light quantum reception antenna matrix；Can also
Can be answered according to certain regularly arranged composition by one or more light quantum transmitting antennas and one or more light quantum reception antennas
Launched with light quantum and reception antenna matrix, each light quantum transmitting antenna and light quantum reception antenna have a fixed volume
Code and a three dimensional space coordinate；Antenna in array is by gating control matrix module control gating.
As shown in figure 4, being a reusable light quantum transmitting and reception antenna matrix embodiment, black round dot is represented in figure
Transmitting antenna, white round dot represents reception antenna, for (3,3) is transmitting antenna center with (X, Y) coordinate, may be constructed 3X3,
The reusable light quantum transmitting of 5X5 ... nXn and reception antenna matrix, but the arrangement mode is not limited to, as long as ensureing wherein extremely
A rare transmitting antenna and reception antenna；As shown in figure 5, when the transmitting of reusable light quantum and the (inspection of reception antenna matrix
Survey matrix) when work in helmet form, each is received and transmitting antenna space coordinates is relatively-stationary, and light quantum is by Fig. 5
The transmitting of transmitting antenna -3, light quantum is by RESONANCE ABSORPTION, refraction, various scatterings (including but not limited to Rayleigh scattering, Raman
Scattering, thomson's scattering, Compton scattering), part light quantum reach reception antenna 1, No. 4 ,-No. 2 (including but not limited to should
3 reception antennas), according to the three-dimensional coordinate and the coordinate of reception antenna of transmitting antenna, can be obtained such as Fig. 5 using mathematical principle
The bent regional location coordinate of middle black disperse, that is, obtain the region of focus and show coordinate data information in reconstruction image.
" transmitting and reception antenna matrix " reception antenna multiplexing as shown in Figure 4 sends instruction by Fig. 1 CPU modules
It is determined that the numbering of the antenna that is re-used (reception antenna and transmitting antenna).
The working method of reusable transmitting and reception antenna matrix is illustrated in figure 6, wherein, light quantum transmitting antenna is constituted
Light quantum transmitting antenna array, i.e., No. 0, No. 3, No. 6 light quantum transmitting antenna arrays for constituting multiplexing, transmitting antenna array can be with
For difference analysis and differential doppler analysis and other applications of not illustrating, Fig. 6 describes light quantum transmitting antenna or light quantity
Sub- reception antenna can be appeared in several hot-wire arrays simultaneously, be gated by gating control matrix majorization, and such as Fig. 6 is by No. 0 No. 1
No. 2 may be constructed hot-wire array Z1, can there is No. 0 No. 1 No. 2 No. 4 No. 5 composition hot-wire array Z2, or by No. 1 No. 2 No. 3 No. 45
Number hot-wire array Z3 is constituted, or constitute hot-wire array Z4 by No. 4 No. 5 No. 6.
In the present invention, the also data rectification module including knowledge based storehouse, because the data that measurement is obtained have reading
Error, environmental error and electrical equipment is aging etc. that time integral causes error etc., therefore the data rectification module in knowledge based storehouse to use
The error compensation method amendment data in knowledge based storehouse, overcome based on statistical noise filtering defect.
As shown in fig. 7, the invention provides a kind of multichannel brain functional imaging method, comprising the following steps：
Step S10, gating control matrix module are produced and launched according to the instruction selection connection light quantum of central processing unit
One or more antennas of module and light quantum receiver module.
Step S20, light quantum are produced and transmitter module is according to the command request of central processing unit, launch two-way light quantum；
Lead up to transmitting antenna and be transmitted into detected tissue, another road is transmitted directly to light quantum receiver module.
Step S30, light quantum receiver module receive the light quantity all the way that light quantum is produced and transmitter module is directly launched respectively
Son, and another road is turned into by after detected brain tissue and by brain tissue including transmitting, refraction, scattering, absorption and light
With rear state and count the light quantum that changes, analyze state and the counting of light quantum, obtain analyzing light quantity subdata with
And hot activity data and biological electricity data.
Step S40, pair can analyze light quantity subdata and hot activity data and biological electricity data are analyzed calculating, obtain
It is detected structural constituent data and is detected the activity of tissue heat and bioelectric data.
Step S50, composition and final hot activity data according to detected tissue and the execution of bioelectric data
Central processing unit is instructed, and carries out respective image reconstruction.
In the present invention, including detection imaging active work mode and detection imaging passive work mode.Wherein,
Detection imaging active work mode sends instruction for central processing unit, by optical quantum generator produce continuous wave spectrum,
The Entangled State light quantum or non-Entangled State light quantum of wave spectrum are fixed in pulse, are launched by antenna emission matrix, via detected
Tissue, is received by light quantum receiver module, then carries out calculating analysis acquisition detected structural constituent data and detected group
Knit final heat activity and bioelectric data etc..
Detection imaging passive work mode sends instruction for central processing unit, and tested tissue is received by light quantum receiver module
Because of light quantum scanning is radiated all the way hot active signal and bioelectric signal, then carry out calculating analysis acquisition tissue
Compositional data, final hot activity data and bioelectric data.Detection imaging passive work mode optical quantum generator is not
Work, the information content that detection imaging passive work mode is obtained is fewer than active work mode.
In the present invention, as shown in figure 8, detection imaging active work mode specifically includes following steps：
Step 101, central processing unit send active detecting instruction and transmitting antenna multiplexing coordinate.
The given light quantum modulation parameter of step 102, light quantum modulation matrix module and light quantum tangle state, and light quantum is adjusted
Parameter processed includes frequency, power (light quantity subnumber), waveform.
Step 103, optical quantum generator produce continuous wave spectrum or the non-Entangled State light quantum of pulse spectrum or Entangled State light
Quantum pair.
Step 104, optical splitter carry out light splitting, and one light quantum of Entangled State quantum centering enters light quantum transmitting antenna, separately
One light quantum enters light quantum receiver module.
The transmitting antenna multiplexing coordinate gating light quantity that step 105, gating control matrix module send according to central processing unit
Sub- transmitting antenna.
Step 106, light quantum transmitting antenna matrix emissive light quantum.
The light quantum reception antenna multiplexing coordinate gating light quantum reception antenna that step 107, central processing unit send is received
Light quantity subsignal.
Step 108, state detection module detection light quantum state.
Step 109, light quantity subsignal is amplified, is demodulated and analog-to-digital conversion, it is numeral to convert analog signals into
Signal.
Step 110, digital filtering module filter noise and unwanted signal.
Step 111, data signal is calculated and analyzed, obtained being detected the composition of tissue and final heat activity
With bioelectric data.
Step 112, basis are detected the composition of tissue and are detected the final hot activity of tissue and bioelectric number
According to carrying out visual image reconstruction.
Wherein, step 111 includes the calculating of light quantum statistical physics, light quantum energy spectrum analysis calculating, light quantum absorption spectra
Calculate, scattering analysis are calculated, differential doppler analytical calculation and difference analysis are calculated.And be with knowledge base to result of calculation finally
Basis carries out data deviation correction.
In the present invention, as shown in figure 9, detection imaging passive work mode flow chart, flow chart description is without master
It is passive to check tissue because of the i.e. heat activity of infra-red radiation that light quantum scanning sends all the way in the case of dynamic launching light quantum signal,
Infra-red radiation is also one kind of light quantum radiation, specifically includes following steps：
Step 201, central processing unit luminescent quantum go out reception antenna multiplexing coordinate.
Step 202, gating control matrix gating light quantum reception antenna.
Step 203, reception antenna matrix reception light quantity subsignal.
Step 204, light quantity subsignal is amplified, and be converted to data signal.
Step 205, enter horizontal electrical signal digital filtering.
Step 206, carry out the calculating of light quantum statistical physics and power spectrum and calculate.
Step 207, data deviation correction is carried out based on knowledge base.
Step 208, according to result of calculation draw digital picture.
Obviously, those skilled in the art can carry out various changes and modification without deviating from essence of the invention to the present invention
God and scope.So, if these modifications of the invention and modification belong to the scope of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to comprising these changes and modification.
Claims (10)
1. a kind of multichannel brain functional imaging device, it is characterised in that including：
Central processing unit, sends light quantum and instruction and gating command occurs；
Light quantum is produced and transmitter module, and the light quantum according to the central processing unit occurs command request, corresponding to occur, send out
Penetrate two-way light quantum；
Light quantum receiver module, receives the light quantum all the way that the light quantum is produced and transmitter module is directly sent respectively, and
Another road through being detected brain tissue and be subject to brain tissue including transmitting, refraction, scattering, absorption and photochemical action after state and
The light quantum that counting changes, analyzes state and the counting of light quantum, obtains corresponding analyzable light quantity subdata, heat activity
Data and bioelectric data；
Gating control matrix module, connects the light quantum generation and launches according to the gating command selection of the central processing unit
One or more light quantum transmitting of module or the light quantum receiver module or reception antenna；
Computation analysis module, analyzable light quantity subdata, hot activity data and bioelectric data to receiving are divided
Analysis is calculated, and obtains being detected the compositional data of tissue and the final hot activity data and bioelectric number of detected tissue
According to；
Image-forming module, according to the computation analysis module send detected tissue compositional data and be detected the final of tissue
Hot activity and bioelectric data perform the central processing unit instruction, carry out corresponding visual image reconstruction.
2. device as claimed in claim 1, it is characterised in that the light quantum is produced and transmitter module modulates square by light quantum
Array element, optical quantum generator, light quantum optical splitter, light quantum transmitting antenna matrix are constituted；Wherein,
The light quantum modulation matrix unit according to the central processing unit send generation instruction to export light quantum frequency,
Power, waveform are modulated coding；The optical quantum generator produces light quantum according to modulated signal；The quantum optical splitter will
The light quantum that generator is produced is divided into two-way；One or more antennas are transmitted into the one route light quantum transmitting antenna matrix
Brain tissue is detected, another road is directly sent to the light quantum receiver module.
3. device as claimed in claim 2, it is characterised in that the light quantum receiver module includes light quantum reception antenna square
Battle array, light quantum state detection unit, light quantum signal amplification unit, light quantity subsignal demodulating and decoding unit, D/A conversion unit
With digital filter unit；Wherein,
One or more antennas of the light quantum reception antenna matrix receive and are directly produced and launched by the light quantum all the way
Module transmitting light quantum, and another road through being detected brain tissue and be subject to brain tissue including reflection, refraction, scatter,
The light quantum changed with state after photochemical action and counting is absorbed, and by the light quantum state detection unit to light quantity
Son carries out state-detection, then by the light quantum signal amplification unit, light quantity subsignal demodulating and decoding unit, digital-to-analogue conversion list
Unit and amplification, demodulating and decoding, digital-to-analogue conversion and the filtering of crossing filter unit, obtain analyzable light quantity subdata, heat activity number
According to biological electricity data.
4. device as claimed in claim 1, it is characterised in that the computation analysis module includes light quantum statistical physics meter
Calculate unit, light quantum energy spectrum analysis statistic unit, light quantum absorption resonance analytic unit and scattering analysis unit, light quantum poor
Divide analytic unit and light quantum differential doppler analytic unit；
The light quantum absorption resonance analytic unit, scattering analysis unit are using the analyzable heat activity and life for being detected tissue
Thing electrical activity data analytical calculation is detected tissue to injecting the absorption spectrum and scattering spectrum of light quantum；
The light quantum energy spectrum analysis statistic unit, the light quantity the analyzed subdata to receiving carries out energy spectrum analysis meter
Calculate；
The light quantum statistical physics computing unit, statistical analysis absorption resonance unit, scattering analysis unit and light quantum
The result of calculation of energy spectrum analysis statistic unit, analysis is obtained being detected the compositional data of tissue and is detected the final heat of tissue
Activity and bioelectric data；
Light quantum difference analysis unit and light quantum differential doppler analytic unit analytical calculation velocity of blood flow or specific components.
5. the device as described in claim 1-4 is any, it is characterised in that the light quantum is produced and transmitting mould occurs, transmitting
Light quantum include non-Entangled State light quantum, Entangled State light quantum pair and non-Entangled State light quantum and Entangled State light quantum to three
The situation of kind；
When there was only non-Entangled State light quantum, the light quantum is produced and it is transmitted into transmitting mould detected brain all the way
Tissue, absorption, reflection, refraction and the scattering and photochemical action that are detected brain tissue change the state of light quantum, and in light
The heat activity of detected brain tissue and bioelectric change under change effect, are received by light quantum receiver module and are detected brain
The heat activity of the light quantum of change in organization's state and detected brain tissue and bioelectric signal, and carry out state-detection and
Amplification, demodulating and decoding, digital-to-analogue conversion and filtering obtain analyzable light quantity subdata, hot activity data and biological electricity data；
Signal is transmitted directly to light quantum receiver module to another non-Entangled State light quantum in road as a comparison, carries out state-detection and puts
Greatly, demodulating and decoding, digital-to-analogue conversion and filtering, obtain analyzable standard light quantity subdata；The computation analysis module is by right
Analyzable light quantity subdata and standard light quantity subdata carry out comparing calculation, and to analyzable light quantity subdata, can divide
The analytical calculation of the hot activity data and biological electricity data of analysis, obtain the compositional data of tested tissue, final hot activity data and
Final biological electricity data；
When there was only Entangled State light quantum pair, the light quantum is produced and transmitter module is by Entangled State light quantum centering
One light quantum is transmitted into detected brain tissue；Another light quantum of Entangled State light quantum centering is transmitted directly to light quantum and connects
Module is received, the light quantum receiver module carries out state-detection to the Entangled State light quantum for being transmitted directly to light quantum receiver module
And amplification, demodulating and decoding, digital-to-analogue conversion and filtering, obtain analyzable light quantity subdata；The computation analysis module passes through
Can analyze light quantity subdata to this carries out calculating compositional data, final hot activity data and biological electricity that analysis obtains tested tissue
Data；
When non-Entangled State light quantum and Entangled State light quantum pair, light quantum is produced and transmitting mould, light quantum receive mould
Block and computation analysis module are entered respectively according to the above-mentioned processing mode for only existing non-Entangled State light quantum or Entangled State light quantum pair
Row treatment；The compositional data of computation analysis module tested tissue again to respectively obtaining, final hot activity data and life
Thing electricity data are counted.
6. device as claimed in claim 5, it is characterised in that the optical quantum generator includes producing multiband pulse light quantity
The multiband pulse light quantum generating unit of son, the continuous wave light quantum generating unit for producing continuous wave light quantum and generation are tangled
The Entangled State light quantum of state light quantum pair is to generating unit；
Multiband pulse light quantum receiving unit of the light quantum reception antenna matrix including reception multiband pulse light quantum,
The continuous wave light quantum receiving unit for receiving continuous wave light quantum and the Entangled State light quantum for receiving Entangled State light quantum receive single
Unit.
7. device as claimed in claim 3, it is characterised in that the light quantum transmitting antenna matrix and the light quantum are received
Antenna array includes the multiple light quantum transmitting antennas and light quantum reception antenna that work independently respectively；
One or more light quantum transmitting antennas and one or more light quantum reception antennas can according to certain regularly arranged composition
The transmitting of multiplexing light quantum and reception antenna matrix, each light quantum transmitting antenna and light quantum reception antenna have one it is fixed
Coding and a three dimensional space coordinate；Antenna in array is by gating control matrix module control gating.
8. device as claimed in claim 1, it is characterised in that the also data rectification module including knowledge based storehouse, using base
In the error compensation method amendment data of knowledge base.
9. a kind of multichannel brain functional imaging method, it is characterised in that comprise the following steps：
Step S10, the instruction selection connection light quantum transmitting antenna matrix according to central processing unit and the reception of corresponding light quantum
One or more antennas of antenna array；
Step S20, the command request according to central processing unit, launch two-way light quantum；Lead up to transmitting antenna be transmitted into by
Detection tissue, another road is transmitted directly to light quantum receiver module；
Step S30, light quantum receiver module receive the light quantum all the way that light quantum is produced and transmitter module is directly launched respectively, with
And another road after detected brain tissue and by brain tissue by including transmitting, refraction, scattering, absorption and shape after photochemical action
The light quantum that state and counting change, analyzes state and the counting of light quantum, obtains that light quantity subdata can be analyzed and heat is living
Dynamic data and biological electricity data；
Step S40, pair can analyze light quantity subdata and hot activity data and biological electricity data are analyzed calculating, be detected
Survey structural constituent data and be detected the final heat activity of tissue and bioelectric data；
Step S50, the final heat activity according to the composition and detection tissue for being detected tissue and bioelectric data are performed
Central processing unit is instructed, and carries out respective image reconstruction.
10. method as claimed in claim 9, it is characterised in that including detection imaging active work mode and detection imaging quilt
Start building operation mode；Wherein,
Detection is imaged active work mode：Central processing unit sends instruction, and continuous wave spectrum, pulse are produced by optical quantum generator
The Entangled State light quantum or non-Entangled State light quantum of fixed wave spectrum, launch by antenna emission matrix, via detected tissue,
Received by light quantum receiver module, then carry out calculating analysis acquisition structural constituent and organize final heat activity and biological electricity
Activity data；
Detection is imaged passive work mode：Central processing unit sends instruction, by light quantum receiver module receive tested tissue because
Light quantum the scanning infrared signal and electrical activity signal that radiate all the way, then carry out calculating analysis obtain structural constituent with
And organize final heat activity and bioelectric data.
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| CN201710146255.2A CN106805970B (en) | 2017-03-13 | 2017-03-13 | Multi-channel brain function imaging device and method |
| PCT/CN2017/077461 WO2018165992A1 (en) | 2017-03-13 | 2017-03-21 | Apparatus and method for multi-channel functional imaging of brain |
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| CN1602808A (en) * | 2004-11-29 | 2005-04-06 | 清华大学 | Multicenter near-infrared diffuseness imaging system for cerebral function image |
| WO2010005969A2 (en) * | 2008-07-07 | 2010-01-14 | The Johns Hopkins University | Advanced cost functions for image registration for automated image analysis: multi-channel, hypertemplate and atlas with built-in variability |
| US8696722B2 (en) * | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
| CN102327111A (en) * | 2011-09-23 | 2012-01-25 | 天津析像光电科技有限公司 | Multichannel near-infrared brain functional imaging parallel detection system |
| CN103156620B (en) * | 2013-03-27 | 2015-01-07 | 中国科学院自动化研究所 | Multi-channel parallel near infrared spectrum imaging system |
| CN104107051B (en) * | 2014-07-31 | 2017-01-11 | 中国科学院自动化研究所 | Portable multiple brain region blood oxygen detection and real-time display system |
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