CN105832292B - Middle and terminal cancer image-forming detecting system based on quantum cosmic string engine and method - Google Patents
Middle and terminal cancer image-forming detecting system based on quantum cosmic string engine and method Download PDFInfo
- Publication number
- CN105832292B CN105832292B CN201610146668.6A CN201610146668A CN105832292B CN 105832292 B CN105832292 B CN 105832292B CN 201610146668 A CN201610146668 A CN 201610146668A CN 105832292 B CN105832292 B CN 105832292B
- Authority
- CN
- China
- Prior art keywords
- photon
- patient
- cancer
- signal
- quantum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Signal Processing (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention discloses a kind of middle and terminal cancer image-forming detecting system and method based on quantum cosmic string engine, mainly solve traditional medicine equipment can not efficiently, safety, quickly, the comprehensive deficiency that detect cancer patient's cancer cell diffusion zone.Its system includes quantum photo-emission source, optical splitter, convex lens, optical filter group, detection unit, image processing unit and display.The cross polarization photon that quantum photo-emission source generates is divided into two-way propagation after optical splitter；A-road-through crosses convex lens and optical filter is radiated at patient, is received by detector after human body；Another way is directly over optical filter, is received by another detector.The photon that two detectors of detection unit pair are detected carries out combined measurement, and result of detection is exported to image processing unit, and the diffusion zone image for being depicted as patient's body cancer cell is shown in display.The present invention can obtain the diffusion zone image of cancer cell, and foundation is provided for the treatment and research of cancer patient.
Description
Technical field
The invention belongs to technical field of electronic equipment, more particularly to a kind of medical imaging detection device can be used in detection
The diffusion zone of cancer cell in patient with advanced cancer body positions cancerous region and is imaged.Pass through information collection, optical computing, figure
As processing, realize that imaging system suffers from patient the cancer cell locating and displaying at cancer position.For the diagnosis, treatment and section of cancer
It learns research and Visual retrieval means and foundation is provided.
Background technology
The maximum cause of death of the cancer as the whole world mankind, growth rate are increasingly accelerated, and the life of the mankind is seriously endangered
Life health and world medicine problem.The annual statistical data report display of American Cancer Society, 2015, the U.S. increased cancer newly
About 1,660,000 people of disease case, dead 600,000 people；The statistical data of the World Health Organization shows that the whole world increased cases of cancer newly in 2014
About 14,100,000 people, death toll reach 8,200,000 people.The World Health Organization is, it is expected that growth and population due to population in the world are aged
The factors such as change and life style, dietary structure and environmental change, by 2025, the world will increase cancer number of cases newly every year to be reached
To 19,300,000 people, annual death will be more than 10,000,000.
Statistical data shows that China increases about 3,500,000 people of cases of cancer, dead 2,000,000 people, cancer newly every year on average in recent years
Incidence has been in first place in the world, accounts for about a quarter of global number of cancer deaths, i.e., China is per minute has 6-7 people to be examined
Break as cancer, and up to 5 people per minute for dying of cancer.
So far, doctor and scientific research personnel can only check cancer, such as X-ray using conventional instrument and test mode
Inspection, CT examination, magnetic resonance MRI are checked.And the type of cancer is up to more than 100 kind, a people for identifying oneself health, absolutely not
It may go all to do each inspection once, these inspections are not only expensive, but also x-ray inspection, calculating employed in clinic
Machine tomoscan CT examination, inherently intense radiation can induce cell carcinogenesis, have certain harm.Therefore, we are often
See, even the people having regular physical checkups every year, can also find suddenly and suffer from cancer, and one it is found that be exactly middle and advanced stage, gives patient's sheet
People, family and society bring huge mental suffering and financial burden.
Therefore it is extremely urgent that a kind of efficient, safe, quick, comprehensive cancer detection means are studied.
Invention content
It is an object of the invention to the deficiency for above-mentioned existing Medical Equipment, propose that one kind is drawn based on quantum cosmic string
The middle and terminal cancer imaging detection method and system held up, to pass through the test to patient's body fluorescin, positioning, qualitative analysis
The diffusion zone of the current cancer cell of patient is obtained, and carries out imaging and shows, foundation is provided for the treatment and research of cancer patient.
Technical scheme is as follows：
One, testing principles
Modern medicine study shows that the fluorescin of different colours can mark intravital different tissues, such as nerveous system
System, cancerous issue etc..The successful research and development of quantum radar demonstrate the realizability of fluorescent quantum imaging, show that quantum theory exists
It has a clear superiority in imaging.Fluorescent quantum image-forming principle can be applied to the fluorescence imaging of internal cancer cell.
The present invention sends out entangled photon pairs by quantum photo-emission source, obtains cross polarization photon pair.Cross polarization photon pair
After the device that is split light splitting, with different propagateds.The polarized photon of wherein detection cancer cell is radiated at by lens and optical filter
On patient body, if patient's body irradiation position has cancer cell, fluorescin to be reacted with cancer cell generation, fluorescence, pole are sent out
Change after photon passes through human body and is received by detector；Another polarized photon is directly over optical filter, is received by another detector.Connection
It closes the photon that two detectors of detection device pair are detected and carries out combined measurement, and result of detection is exported to data processing mould
Fluorescent radiation field, tissue radiation field and quantum detection light radiation field are regarded as entire image-forming radiation field system, pass through spy by block
It surveys photon entanglement pair and the effect of ambient radiation field changes, then the intensity of analyzing radiation field distribution, to obtain fluorescence distribution
Image.Using imaging algorithm, determine to the image reconstruction of fluorescence distribution, and then to the diffusion zone of patient's body cancer cell
Position, quantitative analysis, and be imaged in display and show information.
Two, are according to above-mentioned principle, the middle and terminal cancer image-forming detecting system proposed by the present invention based on quantum cosmic string engine
Including：
Quantum photo-emission source：For generating entangled photon pairs, to obtain the photon of cross polarization, export to optical splitter；
Optical splitter：For changing light path, the photon of cross polarization is made to be propagated along vertical two-way direction；
Planing surface：Position for moving optical splitter adjusts test point；
Convex lens：For converging the photon after optical splitter, photon is made to be irradiated to patient along light path；
Optical filter group：For various coloured light to be played regulatory role and eliminated with light glittering is formed by patient surface instead
Light；
Test bed unit：Make the luminous energy that lens export to patient for carrying patient, and by adjusting the position of test envelope
Carry out full-body exposure scanning；
Detection unit：It receives and detects for irradiating the photon signal that generates after scanning to patient, and by the photon
Signal is conveyed to image processing unit after being converted into digital signal；
Image processing unit：For handling the digital signal that detection unit exports, to obtain fluorescent radiation field strength
Degree exports to imaging display, and establishes the information picture library of the diffusion zone of patient's body cancer cell；
Display：It is shown for carrying out imaging to the fluorescin in cancer patient's body, and checks database file.
The method that three, carry out middle and terminal cancer detection using present system, includes the following steps：
1) normal human is placed on test envelope, test envelope is located in test chamber；Planing surface is placed at the top of test chamber, and
It is connect with optical splitter to control the position of optical splitter, to control the position of test point；The light that quantum photo-emission source is sent out passes through
After paths are irradiated to human body, it is input to detection unit, using image processing unit, obtains the radiation field point of normal human
Cloth data；
2) test result for utilizing step 1 establishes the matrix database of the radiation field intensity distribution of normal human；
3) it is laterally X-axis, longitudinal is Y-axis, establishes two-dimensional coordinate system on the basis of the front view of human body；
4) cancer patient lies on test envelope after injection fluorescin, and receiving irradiation scanning passes through the position for adjusting test envelope
Setting makes the luminous energy of output carry out full-body exposure scanning to patient；
5) BBO Crystal is irradiated with pump laser, is to cross polarization by photon：E light and o light；
6) using optical splitter by photon that light source device generates to being divided into two-way, respectively reference path and signal light path；
7) scanning is irradiated to patient by filter and lens with the polarized photon of signal light path, is subsequently transmitted through people
Body is received by electron multiplication coupling EMCCD detectors；With the polarized photon of reference path by after filter by optical detector
It is received；
8) combined measurement is carried out to two ways of optical signals, the photon signal detected is changed into analog electrical signal, using
Amplification, analog-to-digital conversion become digital signal；
9) it uses wavelet packet threshold denoising method to carry out denoising to digital signal, and fluorescence light is exported by spectrometer
Spectrogram；
10) the cancer cell diffusion zone image of cancer patient is obtained by fluorescence spectra：
10a) after biological tissue transmits, quantum damage transmission probability is fluorescent photon：
Pω=1-2 | min (λ, ω) |2(1-B)(1-Pλ)
Wherein：B is blocking rate, pλFor the classical channel system bit error rate, λ, ω are quantum entanglement channel coefficients.
Transmission probability 10b) is damaged according to quantum, in conjunction with the human body radiation field distribution measured after changing, establishes fluorescent radiation
The detection matrix H of field；
Detection matrix H is compared with normal human's radiation field intensity distribution matrix database 10c), is realized to fluorescence spoke
Penetrate the qualitative and quantitative analysis of field：If the data detected in the data and database in matrix H are variant, illustrate corresponding inspection
There are fluorescins for measuring point, that is, there is cancer cell, by the distribution core of cancer cell in the planar perspective coordinate of human body to get to
The cancer cell diffusion zone image of patient.
11) the cancer cell diffusion zone image of patient is stored in Computer Database, so as to after treatment at
As figure is compared, to evaluate therapeutic effect.
The present invention has the following advantages compared with existing cancer detection system：
1. the present invention determines the label relationship of cancer cell according to fluorescin the diffusion zone of patient's body cancer cell
Position, so positioning is more accurate；
2. the present invention is based on planar perspective coordinate, the cancer cell diffusion zone image of drafting is more intuitive；
3. the present invention is measured in real time using fluorescent quantum imaging technique, cancer cell diffusion region can be provided in the short time
The information in domain has striven for the quality time for the clinical treatment of patient；
4. the present invention is Non-invasive detection, detection process is only to carry out optical scanner to patient, will not be caused to patient new
Wound；
5. the present invention is not limited solely to the detection to cancer, under conditions of obtaining other materials spectrum, it may also be used for
The clinical detection of Other diseases has wide applicability.
Description of the drawings
Fig. 1 is the structural schematic diagram of present system；
Fig. 2 is the structural principle block diagram of present system；
Fig. 3 is the light path block diagram in present system；
Fig. 4 is the implementation flow chart of detection method.
Specific implementation mode
Below in conjunction with attached drawing, present invention is further described in detail.
Referring to Figures 1 and 2, the component for constituting present system includes：Test chamber, test bed unit, spectroanalysis instrument, figure
As processor and display.Wherein test chamber includes quantum photo-emission source 1, optical splitter 2, planing surface 3, convex lens 4, filter
Group 5, detection unit 7.Quantum photo-emission source 1 is located at test chamber top center, the photon pair for sending out cross polarization；It will slide
Face 3 is placed at the top of test chamber, and is connect with optical splitter 2 to control the position of optical splitter, to control the position of test point；Light splitting
Device 2 changes light path, and the photon of cross polarization is made to be propagated along vertical two-way direction；Convex lens 4 is located at below optical splitter, for converging
The poly- photon after optical splitter makes photon be irradiated to patient along light path；The first optical filter 51 in filter group 5 is located at
Below convex lens, it is reflective that glittering is formed by for eliminating light in patient surface；The second optical filter 52 in filter group 5 with
Optical splitter is in the same horizontal position, for being played regulatory role to various coloured light；Detection unit 7 is used to irradiate patient and scan
The photon signal generated afterwards is received and is detected.
The quantum photo-emission source 1, by power supply 11, laser pump (ing) 12, BBO Crystal 13, prism 14, control circuit
15, feedback circuit 16 forms；
The optical filter group 5 is made of the first optical filter 51, the second optical filter 52；
The test bed unit 6, is made of electric machine controller 61, stepper motor 62, test envelope 63；
The detection unit 7 by optical detector 71, EMCCD detectors 72, controller for detection 73, photoelectric converter 74, is put
Big circuit 75, A/D conversion circuits 76 form；
Described image processing unit 8 is made of data processor 81 and spectroanalysis instrument 82.
Power supply 11 in quantum photo-emission source 1 is that laser pump (ing) 12 provides energy, and laser pump (ing) 12 exports optical signal simultaneously
And electric signal, the optical signal first pass through BBO Crystal 13, then after being converged by prism 14, obtain the polarized light of a pair of orthogonal
Son；The electric signal is delivered to control circuit 15 by feedback circuit 16, and control circuit 15 controls electric power output voltage.
Planing surface 3 is connected with optical splitter 2, the position for adjusting test point；Optical splitter 2 changes light path, makes cross polarization
Photon propagated along vertical two-way direction, the photon of signal light road is irradiated by convex lens 4, then by first filter 51
With patient on to test envelope 63, electric machine controller 61 controls stepper motor 62, to control the position of test envelope,
Luminous energy is set to carry out full-body exposure scanning to the patient on test envelope 63；And the photon in another way reference path passes through the second filtering
Device 52 is received by photodetector 71.
Quantum photo-emission source 1, optical splitter 2, convex lens 4, the first optical filter 51, the second optical filter 52, optical detector 71,
EMCCD detectors 72 constitute a light path system, as shown in Figure 3.
Optical detector 71 in detection unit 7 is for detecting the photon signal of reference path, EMCCD detectors
72, it is detected for the photon signal to signal light path, controller for detection 73 is for controlling EMCCD detectors, light
The road combined photon signal detected that measures of reference path and signal light is become analog electrical signal by electric transducer 74, simulation electricity
Signal through amplifying circuit 75 and A/D conversion circuits 76, exports the digital signal of amplification to image processing unit successively.
Output is to spectrum after data processor 81 in image processing unit 8 is used to obtained digital signal carrying out denoising
Instrument 82, spectrometer 82 include fluorescence spectrum chart database and spectrofluorimetry module, fluorescence spectrum chart database, for storing
Fluorescence spectra；Spectrofluorimetry module, for analyzing fluorescence spectra, by calculating the spoke in fluorescence spectra
Field intensity is penetrated, then the radiation field intensity and the distribution of normal human's radiation field intensity are compared, and to patient's body cancer cell
Diffusion zone positioned, quantitative analysis, is depicted as the cancer cell diffusion zone image of cancer patient.
With reference to Fig. 4, the method for carrying out cancer patient's image checking using above system, implementation step is as follows：
Step 1, the radiation field distribution data of normal human are obtained.
(1.1) normal human is placed on test envelope, test envelope is located in test chamber；Planing surface is placed in test chamber top
Portion, and connect with optical splitter to control the position of optical splitter, to control the position of test point；
(1.2) light that quantum photo-emission source is sent out is input to detection unit, then pass through after paths are irradiated to human body
Image processing unit is crossed, the radiation field data of normal human is obtained；
(1.3) by adjusting the position of test point, the luminous energy that quantum photo-emission source is sent out is made to carry out full-body exposure to human body
Scanning, to obtain the radiation field data of normal human's whole body each point.
Step 2, using the test result of step 1, the matrix database of the radiation field intensity distribution of normal human is established.
Step 3, it is laterally X-axis, longitudinal is Y-axis, establishes two-dimensional coordinate system on the basis of the front view of human body.
Step 4, cancer patient lies on test envelope after injection fluorescin, and receiving irradiation scanning passes through and adjusts test envelope
Position so that the luminous energy of output is carried out full-body exposure scanning to patient.
The present invention is the image checking for carrying out suffering from cancerous issue to the label effect of cancer cell based on fluorescin, so
Corresponding fluorescin should be injected before detection to patient.
Step 5, utilization sub-light emission source device generates entangled photon pairs, brilliant using pump laser irradiation barium metaborate
Body.
(5.1) power supply is to laser pump (ing) device with energy, and the voltage signal of pumping laser device output is by feeding back electricity
Road is delivered to control circuit；
(5.2) control circuit controls electric power output voltage, and supply voltage is made to reach stable；
(5.3) voltage stablized makes quantum photo-emission source device generate cross polarization photon pair, makes photon to cross polarization
For：E light and o light.
Step 6, by the photon of cross polarization to being divided into vertical two-way.
(6.1) using optical splitter by photon that quantum photo-emission source generates to being divided into two-way, respectively reference path and letter
Number light path.
(6.2) reference path and signal light path are mutually perpendicular to get to the vertical two-way polarized photon in the direction of propagation.
Step 7, signal light path and reference path polarized photon by respective light path, exported respectively to corresponding spy
It surveys on device.
(7.1) polarized photon of signal light path exposes to test envelope specific position by filter and convex lens along light path；
(7.2) patient is placed on test envelope, electric machine controller adjusts stepper motor, to control the position of test envelope
It sets, the luminous energy of output is made to carry out full-body exposure scanning to patient；
(7.3) signal photon is irradiated scanning to patient, is transmitted across human body, is received by EMCCD detectors.
(7.4) photon of reference path along light path after filter by optical detector by being received.
Step 8, combined measurement is carried out to two-way photon signal, the photon signal detected is changed into analog electrical signal,
Become digital signal using amplification, analog-to-digital conversion.
(8.1) joint-detection is carried out to two-way photon using combined detector, obtains spectral signal；
(8.2) photoelectric switching circuit is used to become analog electrical signal by spectral signal is detected；
(8.3) analog electrical signal is amplified using amplifying circuit；
(8.4) it uses A/D conversion circuits that amplified analog electrical signal is carried out analog-to-digital conversion, becomes digital signal.
Step 9, denoising is carried out to digital signal using wavelet packet threshold denoising method, and is exported by spectrometer glimmering
Light spectrogram；
(9.1a) selects the maximum decomposition scale J of wavelet packet, and J layers of WAVELET PACKET DECOMPOSITION are carried out to digital signal, obtains complete
Binary tree；
(9.1b) since J layers, when the sum of Shannon entropy of two child nodes be less than father node Shannon entropy when, by this two
A child node merges, the WAVELET PACKET DECOMPOSITION coefficient c of finally obtained WAVELET PACKET DECOMPOSITION treei；
(9.1c) is according to noise variance σ and WAVELET PACKET DECOMPOSITION coefficient ciThe data points M computational chart threshold values of equivalent layer：
(9.1d) is using threshold tau to WAVELET PACKET DECOMPOSITION coefficient ciDenoising is carried out, new WAVELET PACKET DECOMPOSITION coefficient is obtained：
(9.1e) is with new WAVELET PACKET DECOMPOSITION coefficient ci' wavelet package reconstruction is carried out, obtain the digital signal after denoising；
(9.2) digital signal after denoising is delivered to spectroanalysis instrument to analyze, exports fluorescence spectra；
(9.3) by the fluorescence spectra export to fluorescence spectrum chart database and spectrofluorimetry module carry out storage and
Analysis.
Step 10, the cancer cell diffusion zone image of cancer patient is obtained by fluorescence spectra.
(10.1) after biological tissue transmits, quantum damage transmission probability is fluorescent photon：
Pω=1-2 | min (λ, ω) |2(1-B)(1-Ρλ),
Wherein：B is blocking rate, ΡλFor the classical channel system bit error rate, λ is quantum entanglement channel coefficients, and ω is classical measures
Son tangles channel coefficients；
(10.2) consider that quantum damages transmission probability, in conjunction with the human body radiation field distribution measured after changing, establish fluorescence spoke
Penetrate the detection matrix H of field：
(10.2a) when detecting human body and having position to send out fluorescence, it is P that system, which detects the initial probability of state that tangles,0, visit
Measure noise photon P1 eProbability be (1-P0), detection photon will can be indicated by thermalization, image-forming photon quantum state with original state：
P2 e=(1- η) P1 e+P0Pe
Wherein：0<η<1, indicate the existence coefficient of photon；PeFor Entangled State density matrix；Pe=| ψ ＞(e)(e)〈Ψ||Ψ>(e)
Represent a two-photon system；
(10.2b) show that the energy of corresponding quantum number is by image-forming photon quantum state：
Wherein：N, β are the quantum number corresponding to different light quantum states；En 0ForCharacteristic value；μ is magnetic conductivity；C is true
The aerial light velocity；Z is the energy for being imaged harmonic oscillator；α is the fine-structure constant of quantum light spectrum image-forming；Wherein：esIt is
The charge of electronics,For reduced Planck constant.
10b3) by different quantum numbers, construction detection matrix
(10.3) detection matrix H is compared with normal human's radiation field intensity distribution matrix database, is realized to fluorescence
The qualitative and quantitative analysis of radiation field；
If the data detected in the data and database in matrix H are variant, illustrate that there are fluorescence for corresponding test point
That is, there is cancer cell in albumen；
If the data in data and database in detection matrix H do not have difference or difference very little, illustrate corresponding detection
Fluorescin is not present in point, that is, cancer cell is not present；
(10.4) distribution core of cancer cell is spread in the planar perspective coordinate of human body to get to the cancer cell of patient
Regional imaging figure.
Step 11, the cancer cell diffusion zone image of patient is stored in Computer Database, so as to after treatment
Image compared, to evaluate therapeutic effect.
Above description is only example of the present invention, does not constitute any limitation of the invention, it is clear that for this
It, all may be without departing substantially from the principle of the invention, structure after having understood the content of present invention and principle for the professional in field
In the case of, various modifications in form and details and change are carried out, but these modifications and variations based on inventive concept are still
Within the claims of the present invention.
Claims (3)
1. a kind of middle and terminal cancer image-forming detecting system based on quantum cosmic string engine, including：
Quantum photo-emission source (1)：For generating entangled photon pairs, to obtain the photon of cross polarization, export to optical splitter；
Optical splitter (2)：For changing light path, the photon of cross polarization is made to be propagated along vertical two-way direction；
Planing surface (3)：Position for moving optical splitter adjusts test point；
Convex lens (4)：For converging the photon after optical splitter, photon is made to be irradiated to patient along light path；
Optical filter group (5)：For various coloured light to be played regulatory role and eliminated with light glittering is formed by patient surface instead
Light；
Test bed unit (6)：For carrying patient, and by adjust the position of test envelope make the luminous energy that lens export to patient into
Row full-body exposure scans；
Detection unit (7)：For the photon signal generated after patient's irradiation scanning to be received and detected, and the photon is believed
It is conveyed to image processing unit after number being converted into digital signal；
Image processing unit (8)：Including data processor (81), spectrometer (82)；What data processor (81) was used to obtain
Spectrometer (82) is given in output after digital signal carries out denoising, and spectrometer (82) analyzes the digital signal, to obtain fluorescence
Spectrogram, and the fluorescence spectra is exported to fluorescence spectrum chart database and spectrofluorimetry module, to obtain cancer trouble
The cancer cell diffusion zone image of person；The spectrometer (82) includes fluorescence spectrum chart database and spectrofluorimetry module,
The fluorescence spectrum chart database, for storing fluorescence spectra；The spectrofluorimetry module, for fluorescence spectra
It is analyzed, by calculating the radiation field intensity in fluorescence spectra, then by the radiation field intensity and normal human's radiation field intensity
Distribution is compared, and is positioned to the diffusion zone of patient's body cancer cell, quantitative analysis, and the cancer of cancer patient is depicted as
Cellular invasion regional imaging figure；
Display (9)：It is shown for carrying out imaging to the fluorescin in cancer patient's body, and checks database file.
2. system according to claim 1, wherein quantum photo-emission source (1), including power supply (11), laser pump (ing) (12),
BBO Crystal (13), prism (14), control circuit (15) and feedback circuit (16)；Power supply (11) is that laser pump (ing) (12) carries
For energy, laser pump (ing) (12) while optical signal and electric signal are exported, which first passes through BBO Crystal (13), then leads to
After crossing prism (14) convergence, the polarized photon of a pair of orthogonal is obtained；The electric signal is delivered to control electricity by feedback circuit (16)
Road (15), control circuit (15) control electric power output voltage.
3. system according to claim 1, detection unit (7) therein, including the coupling of optical detector (71), electron multiplication
EMCCD detectors (72), controller for detection (73), photoelectric converter (74), amplifying circuit (75), A/D conversion circuits (76)；Light
For detector (71) for being detected to the photon signal of reference path, EMCCD detectors (72) are used for the light to signal light path
Subsignal is detected, and controller for detection (73) is for controlling EMCCD detectors, and photoelectric converter (74) is by reference light
Road and the road combined photon signal detected that measures of signal light become analog electrical signal, and the analog electrical signal is successively through amplifying circuit
(75) and A/D conversion circuits (76), the digital signal of amplification is exported to image processing unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610146668.6A CN105832292B (en) | 2016-03-15 | 2016-03-15 | Middle and terminal cancer image-forming detecting system based on quantum cosmic string engine and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610146668.6A CN105832292B (en) | 2016-03-15 | 2016-03-15 | Middle and terminal cancer image-forming detecting system based on quantum cosmic string engine and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105832292A CN105832292A (en) | 2016-08-10 |
| CN105832292B true CN105832292B (en) | 2018-09-11 |
Family
ID=56587971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610146668.6A Expired - Fee Related CN105832292B (en) | 2016-03-15 | 2016-03-15 | Middle and terminal cancer image-forming detecting system based on quantum cosmic string engine and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105832292B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106805970B (en) * | 2017-03-13 | 2020-05-05 | 博睿泰克科技（宁波）有限公司 | Multi-channel brain function imaging device and method |
| CN106955089B (en) * | 2017-04-05 | 2019-05-24 | 博睿泰克科技（宁波）有限公司 | A kind of method and device of cerebral function imaging and brain tissue composition detection |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103308189A (en) * | 2013-06-28 | 2013-09-18 | 中国科学院空间科学与应用研究中心 | Entanglement imaging system and method based on dual-compression coincidence measurements |
| CN105044909A (en) * | 2015-08-18 | 2015-11-11 | 西安电子科技大学 | Anti-interference quantum imaging apparatus and method of weakly absorbed target by sub shot noises |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006038683A1 (en) * | 2004-10-01 | 2008-05-15 | 独立行政法人科学技術振興機構 | High brightness quantum correlation photon beam generator |
| US7428562B2 (en) * | 2004-11-26 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Self-authenticating quantum random number generator |
| EP2887137B1 (en) * | 2013-12-19 | 2018-10-10 | Universität Wien | Quantum imaging with undetected photons |
-
2016
- 2016-03-15 CN CN201610146668.6A patent/CN105832292B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103308189A (en) * | 2013-06-28 | 2013-09-18 | 中国科学院空间科学与应用研究中心 | Entanglement imaging system and method based on dual-compression coincidence measurements |
| CN105044909A (en) * | 2015-08-18 | 2015-11-11 | 西安电子科技大学 | Anti-interference quantum imaging apparatus and method of weakly absorbed target by sub shot noises |
Non-Patent Citations (1)
| Title |
|---|
| Experimental observation of coincidence fractional Fourier transform with entanglement photon pairs;Jianjun Liu等;《Optics Communications》;20090901;第282卷(第17期);第3524-3526页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105832292A (en) | 2016-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Choe | Diffuse optical tomography and spectroscopy of breast cancer and fetal brain | |
| Eda et al. | Multichannel time-resolved optical tomographic imaging system | |
| Davis et al. | Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization | |
| Chaudhari et al. | Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging | |
| CN1253127C (en) | Examination of breast tissue using time-resolved spectroscopy | |
| Marinelli et al. | Experimental determination of the PTW 60019 microDiamond dosimeter active area and volume | |
| Lin et al. | Quantitative fluorescence tomography with functional and structural a priori information | |
| Nishi et al. | High-sensitivity multi-channel probe beam detector towards MEG measurements of small animals with an optically pumped K-Rb hybrid magnetometer | |
| Kamath et al. | Optical pathology using oral tissue fluorescence spectra: classification by principal component analysis and k-means nearest neighbor analysis | |
| Zhang et al. | Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation | |
| CN105832292B (en) | Middle and terminal cancer image-forming detecting system based on quantum cosmic string engine and method | |
| Xu et al. | Optical redox imaging indices discriminate human breast cancer from normal tissues | |
| Ferocino et al. | High throughput detection chain for time domain optical mammography | |
| Wang et al. | Compact fiber-free parallel-plane multi-wavelength diffuse optical tomography system for breast imaging | |
| Kaschke et al. | Transillumination imaging of tissue by phase modulation techniques | |
| Xu et al. | Determination of the optical properties of tissue-simulating phantoms from interstitial frequency domain measurements of relative fluence and phase difference | |
| Choi et al. | Study of propagation of light along an acupuncture meridian | |
| CN107233078A (en) | A kind of cross polarization electrophotographic imager and imaging method | |
| Hall et al. | Simultaneous determination of the second-harmonic generation emission directionality and reduced scattering coefficient from three-dimensional imaging of thick tissues | |
| Wickramasinghe et al. | Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content | |
| CN104068829B (en) | Site spinal cord injury neuronal activity detection system and detection method | |
| Damagatla et al. | Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector | |
| Zhang et al. | Tissue intrinsic fluorescence recovering by an empirical approach based on the PSO algorithm and its application in type 2 diabetes screening | |
| Draeger et al. | In vivo verification of electron paramagnetic resonance biodosimetry using patients undergoing radiation therapy treatment | |
| Papadakis et al. | A fast laser‐based optical‐CT scanner for three‐dimensional radiation dosimetry |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180911 Termination date: 20210315 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |