CN105832292A - Intermediate-advanced stage cancer imaging detecting system and method based on quantum superstring engine - Google Patents
Intermediate-advanced stage cancer imaging detecting system and method based on quantum superstring engine Download PDFInfo
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Abstract
The invention discloses an intermediate-advanced stage cancer imaging detecting system and an intermediate-advanced stage cancer imaging detecting method based on the quantum superstring engine, mainly used for overcoming the defect that the traditional medical device can not efficiently, safely, rapidly and comprehensively detect the cancer cell spreading area of a cancer patient. The intermediate-advanced stage cancer imaging detecting system comprises a quantum light emission source, an optical splitter, a convex lens, a light filter group, a detection unit, an image processing unit and a display. The intermediate-advanced stage cancer imaging detecting method comprises the steps that orthogonal polarized photons generated by the quantum light emission source pass through the optical splitter, and then are transmitted in two paths; one path of the orthogonal polarized photons irradiates the body of the patient through the convex lens and light filters, penetrates through the body and then is received by a detector, and the other path of the orthogonal polarized photons directly passes through the light filters, and are received by another detector; the detection unit carries out combined measurement on the photons detected by the two detectors, and outputs a detection result to the image processing unit, the image processing unit draws a diffusion area imaging picture of cancer cells in the body of the patient, and the diffusion area imaging picture is displayed by the display. With the adoption of the intermediate-advanced stage cancer imaging detecting system and the intermediate-advanced stage cancer imaging detecting method, the diffusion area imaging picture of the cancer cells can be obtained, and thus a basis is provided for the treatment and research on the cancer patient.
Description
Technical field
The invention belongs to technical field of electronic equipment, particularly to a kind of medical imaging detection equipment, can be used in detection
In patient with advanced cancer body, the diffusion zone of cancerous cell, is positioned to picture to cancerous region.By information gathering, optical computing, figure
As steps such as process, it is achieved patient is suffered from the cancerous cell locating and displaying at cancer position by imaging system.Diagnosis, treatment and section for cancer
Learn research and Visual retrieval means and foundation are provided.
Background technology
Cancer is accelerated day by day as the maximum cause of death of the whole world mankind, its growth rate, the life of the serious harm mankind
Life health, is also a world medicine difficult problem.The annual statistical data report display of American Cancer Society, 2015, the U.S. increased cancer newly
Disease case about 1,660,000 people, dead 600,000 people；The statistical data of World Health Organization (WHO) shows, the newly-increased cases of cancer in the whole world in 2014
About 14,100,000 people, death toll reaches 8,200,000 people.World Health Organization (WHO) is it is expected that owing to the growth of population in the world and population are aged
Change, and the factor such as life style, dietary structure and environmental change, by 2025, the world increased cancer number of cases every year newly and will reach
To 19,300,000 people, annual death will be more than 10,000,000.
Statistical data shows, China increases cases of cancer about 3,500,000 people, dead 2,000,000 people, cancer the most every year on average newly
Sickness rate is the first already at the world, accounts for 1/4th of whole world number of cancer deaths, i.e. China 6-7 of having per minute people is examined
Break as cancer, and up to 5 people dying from cancer per minute.
Up to now, doctor and scientific research personnel can only use routine instrument and test mode to check cancer, such as X-ray
Inspection, CT examination, magnetic resonance MRI check.And the kind of cancer up to kind more than 100, a people identifying oneself health, absolutely not
May go all to do once every kind of inspection, these inspections are the most expensive, and x-ray inspection employed in clinic, calculating
Machine tomoscan CT examination, inherently intense radiation, cell carcinogenesis can be induced, there is certain harm.Therefore, we are often
See, even the people having regular physical checkups every year, also can find suddenly and suffer from cancer, and one it is found that be exactly middle and advanced stage, to patient this
People, family and society bring huge psychic pain and financial burden.
Therefore a kind of cancer detection means efficient, safe, quick, comprehensive of research are extremely urgent.
Summary of the invention
Present invention aims to the deficiency of above-mentioned existing Medical Equipment, propose one and draw based on quantum cosmic string
The middle and terminal cancer imaging detection method held up and system, with by the test to fluorescin in the patient, location, qualitative analysis
Obtaining the diffusion zone of the current cancerous cell of patient, and carry out imaging and show, treatment and research for cancer patient provide foundation.
Technical scheme is as follows:
One. Cleaning Principle
Modern medicine study shows, the fluorescin of different colours can be with the intravital different tissues of labelling, such as nerveous system
System, cancerous issue etc..The successful research and development of quantum radar demonstrate the realizability of fluorescent quantum imaging, show that quantum theory exists
Have a clear superiority in imaging.Fluorescent quantum image-forming principle can be applied to the fluorescence imaging of internal cancerous cell.
The present invention is sent entangled photon pairs by quantum photo-emission source, it is thus achieved that cross polarization photon pair.Cross polarization photon pair
It is split after device light splitting, with different propagated.The polarized photon wherein detecting cancerous cell is radiated at by lens and light filter
On patient body, if irradiation position has cancerous cell in the patient, then fluorescin produces reaction with cancerous cell, sends fluorescence, pole
Change photon to be received by detector after human body；Another polarized photon is directly over light filter, is received by another detector.Connection
The photon that two detectors are detected by conjunction detection device carries out combined measurement, and to data, result of detection output is processed mould
Block, detects light radiation field fluorescent radiation field, tissue radiation field and quantum and regards whole image-forming radiation field system as, by visiting
Surveying the effect change of photon entanglement pair and ambient radiation field, the intensity of analyzing radiation field distribution, obtains fluorescence distribution then
Image.Utilize imaging algorithm, the image reconstruction to fluorescence distribution, and then carry out determining to the diffusion zone of cancerous cell in the patient
Position, quantitative analysis, and show information in display imaging.
Two. according to above-mentioned principle, the middle and terminal cancer image-forming detecting system based on quantum cosmic string engine that the present invention proposes
Including:
Quantum photo-emission source: be used for producing entangled photon pairs, thus obtain the photon of cross polarization, output is to beam splitter；
Beam splitter: be used for changing light path, makes the photon of cross polarization propagate along vertical two-way direction；
Planing surface: for moving the position of beam splitter, adjust test point；
Convex lens: for converging through the photon after beam splitter, makes photon be irradiated to patient along light path；
Filter set: glittered instead what patient surface formed for various coloured light being played regulatory role and eliminated light
Light；
Test envelope unit: be used for carrying patient, and make luminous energy that lens export to patient by the position of regulation test envelope
Carry out total irradiation scanning；
Detector unit: the photon signal produced after patient is irradiated scanning is received and detects, and by this photon
Signal flows to graphics processing unit after being converted into digital signal；
Graphics processing unit: for the digital signal of detector unit output is processed, to obtain fluorescent radiation field intensity
Degree, output is to imaging display, and sets up the information picture library of the diffusion zone of cancerous cell in the patient；
Display: show for the fluorescin in cancer patient's body is carried out imaging, and check database file.
Three. the method utilizing present system to carry out middle and terminal cancer detection, comprise the steps:
1) normal human being placed on test envelope, test envelope is positioned at test chamber；Planing surface is placed in test chamber top, and
It is connected with beam splitter to control the position of beam splitter, thus controls the position of test point；The light that quantum photo-emission source sends passes through
After paths is irradiated to human body, it is input to detector unit, then through graphics processing unit, the radiation field obtaining normal human is divided
Cloth data；
2) utilize the test result of step 1, set up the matrix database of the radiation field intensity distribution of normal human；
3) on the basis of the front view of human body, it is laterally X-axis, is longitudinally Y-axis, sets up two-dimensional coordinate system；
4) after cancer patient lies in and injects fluorescin on test envelope, accept to irradiate scanning, by regulating the position of test envelope
Put the luminous energy making output and patient is carried out total irradiation scanning；
5) irradiate BBO Crystal with pump laser, photon is polarized to orthogonal: e light and o light；
6) utilize the photon that light source device is produced by beam splitter to being divided into two-way, respectively reference path and signal light path；
7) by wave filter and lens, patient is irradiated scanning with the polarized photon of signal light path, is subsequently transmitted through people
Body is received by electron multiplication coupling EMCCD detector；With the polarized photon of reference path by after wave filter by photo-detector
Received；
8) two ways of optical signals is carried out combined measurement, the photon signal detected is changed into analog electrical signal, then passes through
Amplify, analog digital conversion becomes digital signal；
9) use wavelet packet threshold denoising method that digital signal carries out denoising, and export fluorescence light by spectrogrph
Spectrogram；
10) the cancerous cell diffusion zone image of cancer patient is obtained by fluorescence spectrum figure:
10a) fluorescent photon is after biological tissue transmits, and its quantum damage transmission probability is:
Pω=1-2 | min (λ, ω) |2(1-B)(1-Pλ)
Wherein: B is blocking rate, pλFor the classical channel system bit error rate, λ, ω are quantum entanglement channel coefficients.
10b) damage transmission probability according to quantum, in conjunction with recording the human body radiation field distribution after change, set up fluorescent radiation
The detection matrix H of field；
10c) detection matrix H is contrasted with normal human radiation field intensity distribution matrix data base, it is achieved to fluorescence spoke
Penetrate the qualitative and quantitative analysis of field: if the data in detection matrix H are variant with the data in data base, then explanation correspondence inspection
There is fluorescin in measuring point, i.e. there is cancerous cell, by the distribution core of cancerous cell in the planar perspective coordinate of human body, i.e. obtains
The cancerous cell diffusion zone image of patient.
11) the cancerous cell diffusion zone image of patient is stored in Computer Database, in order to becoming after treatment
As figure contrasts, evaluate therapeutic effect.
The present invention, compared with existing cancer detection system, has the advantage that
1. the present invention determines the diffusion zone of cancerous cell in the patient according to fluorescin to the labelling relation of cancerous cell
Position, so location is more accurate；
2. the present invention is based on planar perspective coordinate, and the cancerous cell diffusion zone image of drafting is more directly perceived；
3. the present invention uses fluorescent quantum imaging technique to detect in real time, can provide cancerous cell diffusion region in the short time
The information in territory, the clinical treatment for patient has striven for the quality time；
4. the present invention is Non-invasive detection, and detection process is only that patient is carried out optical scanning, will not cause patient new
Wound；
5. the present invention is not limited solely to the detection to cancer, under conditions of obtaining other substance spectra, it may also be used for
The Clinical detection of Other diseases, has wide applicability.
Accompanying drawing explanation
Fig. 1 is the structural representation of present system；
Fig. 2 is the structural principle block diagram of present system；
Fig. 3 is the light path block diagram in present system；
Fig. 4 is the flowchart of detection method.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in further detail.
Seeing figures.1.and.2, the parts constituting present system include: test chamber, test envelope unit, spectroanalysis instrument, figure
As processor and display.Wherein test chamber includes quantum photo-emission source 1, beam splitter 2, planing surface 3, convex lens 4, wave filter
Group 5, detector unit 7.Quantum photo-emission source 1 is positioned at test chamber top center, for sending the photon pair of cross polarization；To slide
Face 3 is placed in test chamber top, and is connected the position controlling beam splitter with beam splitter 2, thus controls the position of test point；Light splitting
Device 2 changes light path, makes the photon of cross polarization propagate along vertical two-way direction；Convex lens 4 is positioned at below beam splitter, is used for converging
Poly-through the photon after beam splitter, make photon be irradiated to patient along light path；The first light filter 51 in bank of filters 5 is positioned at
Below convex lens, reflective glittering of being formed of patient surface for eliminating light；The second light filter 52 in bank of filters 5 with
Beam splitter is on same level position, for playing regulatory role various coloured light；Detector unit 7 is for irradiating scanning to patient
The photon signal of rear generation is received and detects.
Described quantum photo-emission source 1, by power supply 11, laser pump (ing) 12, BBO Crystal 13, prism 14, control circuit
15, feedback circuit 16 forms；
Described filter set 5 is made up of first light filter the 51, second light filter 52；
Described test envelope unit 6, is made up of electric machine controller 61, motor 62, test envelope 63；
Described detector unit 7, by photo-detector 71, EMCCD detector 72, controller for detection 73, optical-electrical converter 74, puts
Big circuit 75, A/D change-over circuit 76 form；
Described graphics processing unit 8, is made up of data processor 81 and spectroanalysis instrument 82.
Power supply 11 in quantum photo-emission source 1 provides energy, laser pump (ing) 12 to export optical signal for laser pump (ing) 12 simultaneously
And the signal of telecommunication, this optical signal first passes through BBO Crystal 13, then after being converged by prism 14, it is thus achieved that the light of pair of orthogonal polarization
Son；This signal of telecommunication is delivered to control circuit 15 by feedback circuit 16, and electric power output voltage is controlled by control circuit 15.
Planing surface 3 is connected with beam splitter 2, for adjusting the position of test point；Beam splitter 2 changes light path, makes cross polarization
Photon propagate along vertical two-way direction, the photon in signal light path passes through convex lens 4, then is irradiated by the first wave filter 51
With patient to test envelope 63, motor 62 is controlled by electric machine controller 61, thus controls the position of test envelope,
Make luminous energy that the patient on test envelope 63 is carried out total irradiation scanning；And the photon in another road reference path is by the second filtering
Device 52 is received by photodetector 71.
Quantum photo-emission source 1, beam splitter 2, convex lens 4, the first light filter 51, the second light filter 52, photo-detector 71,
EMCCD detector 72 constitutes a light path system, as shown in Figure 3.
Photo-detector 71 in detector unit 7 is used for detecting the photon signal of reference path, EMCCD detector
72, for detecting the photon signal of signal light path, controller for detection 73 is used for being controlled EMCCD detector, light
The photon signal that road combined to reference path and flashlight measurement detects is become analog electrical signal by electric transducer 74, this simulation electricity
The most amplified circuit of signal 75 and A/D change-over circuit 76, the digital signal that output is amplified is to graphics processing unit.
Data processor 81 in graphics processing unit 8 exports to spectrum after the digital signal obtained is carried out denoising
Instrument 82, spectrogrph 82 includes fluorescence spectrum chart database and spectrofluorimetry module, fluorescence spectrum chart database, is used for storing
Fluorescence spectrum figure；Spectrofluorimetry module, for being analyzed fluorescence spectrum figure, by calculating the spoke in fluorescence spectrum figure
Penetrate field intensity, then this radiation field intensity is contrasted with the distribution of normal human's radiation field intensity, and to cancerous cell in the patient
Diffusion zone carries out positioning, quantitative analysis, is depicted as the cancerous cell diffusion zone image of cancer patient.
With reference to Fig. 4, utilizing the method that said system carries out cancer patient's image checking, implementation step is as follows:
Step 1, obtains the radiation field distribution data of normal human.
(1.1) normal human being placed on test envelope, test envelope is positioned at test chamber；Planing surface is placed in test chamber top
Portion, and be connected with beam splitter to control the position of beam splitter, thus control the position of test point；
(1.2) light that quantum photo-emission source sends is after paths is irradiated to human body, is input to detector unit, then warp
Cross graphics processing unit, obtain the radiation field data of normal human；
(1.3) by adjusting the position of test point, the luminous energy making quantum photo-emission source send carries out total irradiation to human body
Scanning, thus obtain the radiation field data of normal human's whole body each point.
Step 2, utilizes the test result of step 1, sets up the matrix database of the radiation field intensity distribution of normal human.
Step 3, on the basis of the front view of human body, is laterally X-axis, is longitudinally Y-axis, sets up two-dimensional coordinate system.
Step 4, cancer patient lies in after injecting fluorescin on test envelope, accepts to irradiate scanning, by regulation test envelope
Position make the luminous energy of output that patient is carried out total irradiation scanning.
The present invention is the image checking labelling effect of cancerous cell being suffered from cancerous issue based on fluorescin, so
The fluorescin of correspondence should be injected to patient before detection.
Step 5, utilizes quantum photo-emission source device to produce entangled photon pairs, uses pump laser to irradiate barium metaborate brilliant
Body.
(5.1) power supply is to laser pump (ing) device with energy, and the voltage signal of pumping laser device output is by feedback electricity
Road is delivered to control circuit；
(5.2) electric power output voltage is controlled by control circuit, makes supply voltage reach stable；
(5.3) stable voltage makes quantum photo-emission source device produce cross polarization photon pair, makes photon to cross polarization
For: e light and o light.
Step 6, by the photon of cross polarization to being divided into vertical two-way.
(6.1) utilize the photon that quantum photo-emission source is produced by beam splitter to being divided into two-way, respectively reference path and letter
Number light path.
(6.2) reference path and signal light path are mutually perpendicular to, and i.e. obtain the two-way polarized photon that the direction of propagation is vertical.
Step 7, signal light path and the polarized photon of reference path by respective light path, the spy that output is the most corresponding respectively
Survey on device.
(7.1) polarized photon of signal light path passes through wave filter and convex lens, exposes to test envelope ad-hoc location along light path；
(7.2) patient being placed on test envelope, electric machine controller adjusts motor, thus controls the position of test envelope
Put, make the luminous energy of output that patient is carried out total irradiation scanning；
(7.3) signal photon is irradiated scanning to patient, transmits through human body, is received by EMCCD detector.
(7.4) photon of reference path is received by photo-detector by wave filter tailing edge light path.
Step 8, carries out combined measurement to two-way photon signal, and the photon signal detected is changed into analog electrical signal,
Again through amplifying, analog digital conversion becomes digital signal.
(8.1) utilize combined detector that two-way photon is carried out joint-detection, obtain spectral signal；
(8.2) use photoelectric switching circuit that detection spectral signal is become analog electrical signal；
(8.3) amplifying circuit is used to be amplified by analog electrical signal；
(8.4) analog electrical signal after using A/D change-over circuit to amplify carries out analog digital conversion, becomes digital signal.
Step 9, is used wavelet packet threshold denoising method that digital signal carries out denoising, and is exported by spectrogrph glimmering
Light spectrogram；
(9.1a) select the maximum decomposition scale J of wavelet packet, digital signal is carried out J layer WAVELET PACKET DECOMPOSITION, obtain complete
Binary tree；
(9.1b) from the beginning of J layer, when the Shannon entropy sum of two child nodes is less than the Shannon entropy of father node, by this two
Individual child node merges, the WAVELET PACKET DECOMPOSITION coefficient c of the WAVELET PACKET DECOMPOSITION tree finally giveni；
(9.1c) according to noise variance σ and WAVELET PACKET DECOMPOSITION coefficient ciThe data of equivalent layer are counted M computational chart threshold value:
(9.1d) use threshold tau to WAVELET PACKET DECOMPOSITION coefficient ciCarry out denoising Processing, obtain new WAVELET PACKET DECOMPOSITION coefficient:
(9.1e) with new WAVELET PACKET DECOMPOSITION coefficient ci' carry out wavelet package reconstruction, it is thus achieved that the digital signal after denoising；
(9.2) digital signal after denoising is delivered to spectroanalysis instrument be analyzed, exports fluorescence spectrum figure；
(9.3) by this fluorescence spectrum figure output to fluorescence spectrum chart database and spectrofluorimetry module carry out storage and
Analyze.
Step 10, is obtained the cancerous cell diffusion zone image of cancer patient by fluorescence spectrum figure.
(10.1) fluorescent photon is after biological tissue transmits, and its quantum damage transmission probability is:
Pω=1-2 | min (λ, ω) |2(1-B)(1-Ρλ),
Wherein: B is blocking rate, ΡλFor the classical channel system bit error rate, λ is quantum entanglement channel coefficients, and ω is classical amount
Son tangles channel coefficients；
(10.2) consider quantum damage transmission probability, in conjunction with recording the human body radiation field distribution after change, set up fluorescence spoke
Penetrate the detection matrix H of field:
(10.2a) when detecting human body and having position to send fluorescence, system detects and initially tangles probability of state is P0, visit
Measure noise photon P1 eProbability be (1-P0), detection photon will be by transconversion into heat, and image-forming photon quantum state can represent by original state:
P2 e=(1-η) P1 e+P0Pe
Wherein: 0 < η < 1, the existence coefficient of photon is represented；PeFor Entangled State density matrix；Pe=| ψ ＞(e)(e)〈Ψ||Ψ>(e)
Represent a two-photon system；
(10.2b) shown that the energy of corresponding amount subnumber is by image-forming photon quantum state:
Wherein: n, β are different quantum numbers corresponding to light quantum state；En 0ForCharacteristic value；μ is pcrmeability；C is true
The aerial light velocity；Z is the energy of imaging harmonic oscillator；α is the fine-structure constant of quantum light spectrum image-forming；Wherein: esIt is
The electric charge of electronics,For reduced Planck constant.
10b3) by different quantum numbers, structure detection matrix
(10.3) detection matrix H is contrasted with normal human radiation field intensity distribution matrix data base, it is achieved to fluorescence
The qualitative and quantitative analysis of radiation field；
If the data in detection matrix H are variant with the data in data base, then there is fluorescence in the corresponding test point of explanation
, i.e. there is cancerous cell in albumen；
If the data in detection matrix H and the data in data base do not have difference or difference the least, then explanation correspondence detection
There is not fluorescin in point, the most there is not cancerous cell；
(10.4) by the distribution core of cancerous cell in the planar perspective coordinate of human body, the cancerous cell diffusion of patient is i.e. obtained
Regional imaging figure.
Step 11, is stored in the cancerous cell diffusion zone image of patient in Computer Database, in order to after treatment
Image contrast, evaluate therapeutic effect.
Above description is only example of the present invention, does not constitute any limitation of the invention, it is clear that for this
For the professional in field, after having understood present invention and principle, all may be without departing substantially from the principle of the invention, structure
In the case of, carry out the various modifications and changes in form and details, but these corrections based on inventive concept and change are still
Within the claims of the present invention.
Claims (7)
1. a middle and terminal cancer image-forming detecting system based on quantum cosmic string engine, including:
Quantum photo-emission source (1): be used for producing entangled photon pairs, thus obtain the photon of cross polarization, output is to beam splitter；
Beam splitter (2): be used for changing light path, makes the photon of cross polarization propagate along vertical two-way direction；
Planing surface (3): for moving the position of beam splitter, adjust test point；
Convex lens (4): for converging through the photon after beam splitter, makes photon be irradiated to patient along light path；
Filter set (5): glittered instead what patient surface formed for various coloured light being played regulatory role and eliminated light
Light；
Test envelope unit (6): be used for carrying patient, and patient is entered by the luminous energy making lens export by the position of regulation test envelope
Row total irradiation scans；
Detector unit (7): the photon signal produced after patient is irradiated scanning is received and detects, and is believed by this photon
Graphics processing unit is flowed to after number being converted into digital signal；
Graphics processing unit (8): for the digital signal of detector unit output is processed, to obtain fluorescent radiation field intensity
Degree, output is to imaging display, and sets up the information picture library of the diffusion zone of cancerous cell in the patient；
Display (9): show for the fluorescin in cancer patient's body is carried out imaging, and check database file.
2., according to the system described in right 1, wherein quantum photo-emission source (1), including power supply (11), laser pump (ing) (12), inclined boron
Acid crystal of barium (13), prism (14), control circuit (15) and feedback circuit (16)；Power supply (11) is that laser pump (ing) (12) provides energy
Amount, laser pump (ing) (12) exports optical signal and the signal of telecommunication simultaneously, and this optical signal first passes through BBO Crystal (13), then passes through rib
After mirror (14) converges, it is thus achieved that the photon of pair of orthogonal polarization；This signal of telecommunication is delivered to control circuit by feedback circuit (16)
(15), electric power output voltage is controlled by control circuit (15).
3., according to the system described in right 1, detector unit therein (7), including photo-detector (71), electron multiplication coupling
EMCCD detector (72), controller for detection (73), optical-electrical converter (74), amplifying circuit (75), A/D change-over circuit (76)；Light
Detector (71) is for detecting the photon signal of reference path, and EMCCD detector (72) is for the light to signal light path
Subsignal detects, and controller for detection (73) is for being controlled EMCCD detector, and optical-electrical converter (74) is by reference light
The photon signal that road and the road combined measurement of flashlight detect becomes analog electrical signal, the most amplified circuit of this analog electrical signal
(75) digital signal that and A/D change-over circuit (76), output is amplified is to graphics processing unit.
4., according to the system described in right 1, wherein said graphics processing unit (8), including data processor (81), spectrogrph
(82)；Data processor (81) exports to spectrogrph (82), spectrogrph (82) after the digital signal obtained is carried out denoising
This digital signal is analyzed, to obtain fluorescence spectrum figure, and this fluorescence spectrum figure is exported to fluorescence spectrum chart database
With spectrofluorimetry module, to obtain the cancerous cell diffusion zone image of cancer patient.
System the most according to claim 4, spectrogrph therein includes fluorescence spectrum chart database and spectrofluorimetry
Module,
Described fluorescence spectrum chart database, is used for storing fluorescence spectrum figure；
Described spectrofluorimetry module, for being analyzed fluorescence spectrum figure, by calculating the radiation in fluorescence spectrum figure
Field intensity, then this radiation field intensity is contrasted with the distribution of normal human's radiation field intensity, and the expansion to cancerous cell in the patient
Scattered region carries out positioning, quantitative analysis, is depicted as the cancerous cell diffusion zone image of cancer patient.
6. the method utilizing claim 1 to carry out middle and terminal cancer image checking, comprises the steps:
1) normal human being placed on test envelope, test envelope is positioned at test chamber；Planing surface is placed in test chamber top, and with point
Light device connects to control the position of beam splitter, thus controls the position of test point；The light that quantum photo-emission source sends is through light path
After propagation is irradiated to human body, it is input to detector unit, then through graphics processing unit, obtains the radiation field distribution number of normal human
According to；
2) utilize the test result of step 1, set up the matrix database of the radiation field intensity distribution of normal human；
3) on the basis of the front view of human body, it is laterally X-axis, is longitudinally Y-axis, sets up two-dimensional coordinate system；
4) after cancer patient lies in and injects fluorescin on test envelope, accept to irradiate scanning, made by the position of regulation test envelope
The luminous energy of output carries out total irradiation scanning to patient；
5) irradiate BBO Crystal with pump laser, photon is polarized to orthogonal: e light and o light；
6) utilize the photon that light source device is produced by beam splitter to being divided into two-way, respectively reference path and signal light path；
7) by wave filter and lens, patient is irradiated scanning with the polarized photon of signal light path, is subsequently transmitted through human body quilt
EMCCD detector is received；Received by photo-detector by after wave filter with the polarized photon of reference path；
8) two ways of optical signals is carried out combined measurement, the photon signal detected is changed into analog electrical signal, then through amplifying,
Analog digital conversion becomes digital signal；
9) use wavelet packet threshold denoising method that digital signal is carried out denoising, and export fluorescence spectrum by spectrogrph
Figure；
10) the cancerous cell diffusion zone image of cancer patient is obtained by fluorescence spectrum figure:
10a) fluorescent photon is after biological tissue transmits, and its quantum damage transmission probability is:
Pω=1-2 | min (λ, ω) |2(1-B)(1-Pλ)
Wherein: B is blocking rate, pλFor the classical channel system bit error rate, λ is quantum entanglement channel coefficients, and ω is classical quantum entanglement
Channel coefficients；
10b) damage transmission probability according to quantum, in conjunction with recording the human body radiation field distribution after change, set up fluorescent radiation field
Detection matrix H；
10c) detection matrix H is contrasted with normal human radiation field intensity distribution matrix data base, it is achieved to fluorescent radiation field
Qualitative and quantitative analysis: if detection matrix H in data variant with the data in data base, then explanation correspondence test point
There is fluorescin, i.e. there is cancerous cell；
If the data in detection matrix H and the data in data base do not have difference or difference the least, then the corresponding test point of explanation is not
There is fluorescin, the most there is not cancerous cell；
By the distribution core of cancerous cell in the planar perspective coordinate of human body, i.e. obtain the cancerous cell diffusion zone imaging of patient
Figure.
11) the cancerous cell diffusion zone image of patient is stored in Computer Database, in order to the image after treatment
Contrast, evaluate therapeutic effect.
7. by the middle and terminal cancer imaging detection method described in right 6, wherein step 10b) according to quantum damage transmission probability,
In conjunction with recording the human body radiation field distribution after change, set up the detection matrix H of fluorescent radiation field, carry out as follows；
10b1) when detecting human body and having position to send fluorescence, system detects and initially tangles probability of state is P0, detect and make an uproar
The sub-P of acousto-opticl eProbability be (1-P0), detection photon will be by transconversion into heat, and image-forming photon quantum state can represent by original state:
Wherein: 0 < η < 1, the existence coefficient of photon is represented；PeFor Entangled State density matrix；Pe=| ψ ＞(e)(e)＜ ψ | wherein: | ψ ＞(e)
Represent a two-photon system；
10b2) shown that the energy of corresponding amount subnumber is by image-forming photon quantum state:
Wherein: n, β are different quantum numbers corresponding to light quantum state；En 0ForCharacteristic value；μ is pcrmeability；C is light in vacuum
Speed；Z is the energy of imaging harmonic oscillator；α is the fine-structure constant of quantum light spectrum image-forming；Wherein: esIt it is electronics
Electric charge,For reduced Planck constant.
10b3) by different quantum numbers, structure detection matrix
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