CN106805970B - Multi-channel brain function imaging device and method - Google Patents
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Abstract
The invention discloses a multichannel brain function imaging device and method, and the method comprises the following steps: one or more transmitting antennas and one or more receiving antennas are selected to be switched on according to the instruction of the central processing unit, and two paths of light quanta are transmitted; one path is transmitted to the detected tissue through a transmitting antenna, and the other path is directly transmitted to a light quantum receiving module; the photon receiving module receives one path of directly emitted photons and the other path of photons with changed reflection, refraction, scattering and photochemical action states through the detected tissue, and analyzes and calculates the photon states to obtain final detected tissue component data and detected tissue thermal activity and bioelectricity activity data; and executing a central processor instruction according to the activity data to reconstruct a corresponding image. The invention has stronger scanning capability, more direct and sensitive measurement data, larger and more stable information quantity and no time delay.
Description
Technical Field
The invention relates to a brain function imaging technology in the field of medical detection, in particular to a multi-channel brain function imaging device and method.
Background
In the field of medical detection, visual medical images can help medical workers to make diagnoses according to human physiology and pathological changes, the medical workers make abnormal comparison between the medical images and familiar normal images, so that correct diagnoses are made, the quality and quantity of information displayed by the visible medical images are the basis of image diagnostics, and the information content abundance degree of the images is very important for making correct diagnoses.
Medical image imaging comprises X-Ray, ultrasonic, CT, MRI, MEG, PET, NIRS and the like, generally, medical image imaging technology is divided into two types of projection imaging and reconstruction imaging, for example, fracture X-Ray imaging utilizes tissues to carry out direct projection imaging on different X-Ray absorption values, and diagnosis is carried out according to human anatomy, physiology and pathological changes; however, for diseases such as 'inflammation' which need to be diagnosed at molecular level, the human anatomy structure can not be presented by a photographic method for morphological diagnosis, but invisible information can be reconstructed into a visualized medical image through calculation assistance, for example, the intensity of a gray image directly simulated by X-Ray and the change thereof reflect the anatomical and pathological changes of the human anatomy structure, but the X-Ray image covers and cannot display some tissue or focus projections, CT reconstructs a simulated image through digital transformation on the basis of X-Ray, higher image resolution capability is provided, the problem of X-Ray inspection image overlapping is solved, and the focus detection rate is improved.
With the development of the technology, on the basis of the calculation-aided reconstruction imaging, a functional imaging technology capable of presenting information which cannot be observed by morphological examination in an image form, such as information of blood flow direction and flow velocity, appears; the functional imaging technology breaks through the defect of morphological diagnosis, further expands the application range of the imaging technology, and at present, the related main aspects comprise neurophysiology and neuropsychology, and are gradually expanded to the research on functional cortex such as hearing, language, cognition, emotion and the like and psychological activities such as memory and the like. The functional imaging technology can provide sensitive, objective and accurate information evaluation for research, diagnosis, progress estimation and experimental intervention treatment effect evaluation of nerve diseases. Functional imaging studies of neurophysiologic brain neuropathy involve epilepsy, Parkinson's disease, Alzheimer's Disease (AD), Multiple Sclerosis (MS), and cerebral infarction.
Functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) are both functional imaging techniques for cerebral neuropathy, and fMRI and fNIRS images contain not only anatomical information but also a reaction mechanism of the nervous system. At present, fNIRS and fMRI measure brain activity by using blood flow and blood oxygen changes, and the difference is that fMRI uses magnetic array imaging, and fNIRS uses scattering change of hemoglobin in blood vessels to near infrared light.
Functional magnetic resonance brain imaging (fMRI) technology has important significance for early diagnosis, identification, treatment and follow-up of diseases due to high resolution of time and space, but fMRI has irreparable defects, such as incapability of being used for patients with early pregnancy and respiratory system and patients with ferromagnetic implants, MRI contrast with Gd contrast agent has certain influence on renal function, and artifacts cannot be completely eliminated; in addition, fMRI detects blood oxygen changes that are not synchronized with the neural electrical signals, and the peak values of the blood oxygen signals generally lag the neural activity by about 6 s.
The functional near infrared spectrum brain imaging (fNIRS) technology is a method for dynamically detecting brain function developed in recent years, and has the characteristics of compatibility with magnetic metal articles, permission of long-time continuous measurement, repeated multiple measurements in short time and the like; signals from different brain structures can be distinguished accurately, the spatial resolution reaches 1-2 mm, the sampling rate of the fNIRS can reach 0.1 second and is far higher than that of functional magnetic resonance imaging, and the near infrared optical imaging technology of the dispersive optical imaging represents the development direction of future cognitive neuroscience. Meanwhile, the functional near infrared spectrum brain imaging technology has the following defects:
(1) NIRS has a relatively poor penetration, generally considered to penetrate only 3-8cm of skin;
(2) fNIRS, like fMRI, has a limited ability to resolve tissue components, and due to its narrow frequency band, the spectra of some molecular species in this spectral range overlap with the spectra of other species in the human body, and the scan data is poorly accurate, e.g., for glucose detection, although the analysis information of the detected glucose is provided in the near infrared spectrum range, but the optimal spectral range is between 2.0um and 2.5um, although the spectra of glucose are independent, but overlaps with the spectrum of other substances in the human body in this spectral range, which results in little penetration of near infrared light subcutaneously and little absorbance of glucose, and on the other hand, while there is indeed a correlation between the bulk blood glucose level and the measured optical signal, no non-invasive experiment provides evidence that the measured signal can be correlated to actual blood glucose concentration, thus making it difficult to measure glucose by fNIRS;
(3) like fMRI, fNIRS estimates brain tissue activity through oxygen consumption, and has poor measurement sensitivity, instability, low accuracy and large time delay.
Disclosure of Invention
The invention aims to solve the technical problems of poor brain function imaging scanning capability, poor measurement sensitivity, instability, low accuracy and larger time delay in the prior art.
In order to solve the above technical problem, the present invention adopts a technical solution of providing a multi-channel brain function imaging apparatus, including:
the central processing unit is used for sending out a photon generation instruction and a gating instruction;
the light quantum generating and emitting module correspondingly generates and emits two paths of light quanta according to the light quantum generating instruction requirement of the central processing unit;
the light quantum receiving module is used for respectively receiving one path of light quantum directly sent by the light quantum generating and transmitting module, and the other path of light quantum which passes through the detected brain tissue and is subjected to the state and counting change after the brain tissue has the functions of transmission, refraction, scattering, absorption and photochemistry, and analyzing the state and counting of the light quantum to obtain corresponding analyzable light quantum data, thermal activity data and bioelectricity activity data;
the gating control matrix module is used for selectively switching on one or more light quantum transmitting or receiving antennas of the light quantum generating and transmitting module or the light quantum receiving module according to a gating instruction of the central processing unit;
the calculation analysis module is used for analyzing and calculating the received analyzable light quantum data, thermal activity data and bioelectricity activity data to obtain component data of the detected tissue and final thermal activity data and bioelectricity activity data of the detected tissue;
and the imaging module executes the instruction of the central processing unit according to the component data of the detected tissue and the final thermal activity and bioelectrical activity data of the detected tissue sent by the calculation and analysis module, and performs corresponding visual image reconstruction.
In the above device, the photon generating and emitting module is composed of a photon modulation matrix unit, a photon generator, a photon splitter, and a photon emitting antenna matrix; wherein the content of the first and second substances,
the light quantum modulation matrix unit modulates and codes the frequency, power and waveform of output light quantum according to a generation instruction sent by the central processing unit; the light quantum generator generates light quantum according to the modulation signal; the quantum splitter divides the light quantum generated by the generator into two paths; one path is transmitted to the detected brain tissue by one or more antennas in the light quantum transmitting antenna matrix, and the other path is directly transmitted to the light quantum receiving module.
In the above device, the photon receiving module includes a photon receiving antenna matrix, a photon state detecting unit, a photon signal amplifying unit, a photon signal demodulating and decoding unit, a digital-to-analog converting unit, and a digital filtering unit; wherein the content of the first and second substances,
one or more antennas of the optical quantum receiving antenna matrix receive one path of optical quantum which is directly generated by the optical quantum generation and emission module, and the other path of optical quantum which is subjected to the brain tissue detection and is changed in state and count after being reflected, refracted, scattered, absorbed and photochemical, and the state of the optical quantum is detected by the optical quantum state detection unit, and the optical quantum is amplified, demodulated, decoded, converted and filtered by the optical quantum signal amplification unit, the optical quantum signal demodulation and decoding unit, the digital-to-analog conversion unit and the filtering unit to obtain analyzable optical quantum data, thermal activity data and bioelectricity data.
In the above device, the computational analysis module includes a photon statistics physics computing unit, a photon energy spectrum analysis statistical unit, a photon absorption resonance analysis unit and a scattering analysis unit, a photon differential analysis unit and a photon differential doppler analysis unit;
the photon absorption resonance analysis unit and the scattering analysis unit analyze and calculate the absorption spectrum and the scattering spectrum of the detected tissue to the incident photons by utilizing the analyzable thermal activity and bioelectricity activity data of the detected tissue;
the light quantum energy spectrum analysis statistical unit is used for carrying out energy spectrum analysis calculation on the received analyzable light quantum data;
the photon statistics physics calculation unit is used for carrying out statistics analysis on the calculation results of the absorption resonance unit, the scattering analysis unit and the photon energy spectrum analysis and statistics unit to obtain the component data of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue through analysis;
the light quantum differential analysis unit and the light quantum differential Doppler analysis unit analyze and calculate the blood flow velocity or specific components.
In the above device, the optical quantum generation and emission mode generation, the emitted optical quantum includes three cases of non-entangled optical quantum, entangled optical quantum pair, and non-entangled optical quantum and entangled optical quantum pair;
for the condition that only non-entangled-state light quanta exist, the light quantum generating and emitting module emits one path of light quanta to the detected brain tissue, the absorption, reflection, refraction, scattering and photochemical action of the detected brain tissue change the state of the light quanta, the thermal activity and the bioelectrical activity of the detected brain tissue are changed under the photochemical action, the light quanta receiving module receives the light quanta of the changed state of the detected brain tissue and the thermal activity and bioelectrical activity signals of the detected brain tissue, and the state detection, the amplification, the demodulation and the decoding, the digital-to-analog conversion and the filtering are carried out to obtain analyzable light quanta data, thermal activity data and bioelectrical data; the other path of non-entangled state light quantum is directly sent to a light quantum receiving module as a contrast signal for state detection, amplification, demodulation and decoding, digital-to-analog conversion and filtering to obtain analyzable standard light quantum data; the calculation analysis module is used for comparing and calculating analyzable light quantum data and standard light quantum data and analyzing and calculating analyzable light quantum data, analyzable thermal activity data and bioelectricity data to obtain component data, final thermal activity data and final bioelectricity data of the tested tissue;
for the case of only entangled-state photon pairs, the photon generation and emission module emits one photon of the entangled-state photon pairs to the detected brain tissue; the other optical quantum in the entangled-state optical quantum pair is directly sent to an optical quantum receiving module, and the optical quantum receiving module carries out state detection, amplification, demodulation and decoding, digital-to-analog conversion and filtering on the entangled-state optical quantum directly sent to the optical quantum receiving module to obtain analyzable optical quantum data; the calculation analysis module is used for calculating and analyzing the analyzable light quantum data to obtain component data, final thermal activity data and bioelectricity data of the detected tissue;
for the conditions of the non-entangled-state photon pairs and the entangled-state photon pairs, the photon generation and emission module, the photon receiving module and the calculation and analysis module respectively process the non-entangled-state photon pairs or the entangled-state photon pairs according to the processing mode; and the calculation analysis module is used for counting the obtained component data of the tested tissue, the final thermal activity data and the bioelectricity data respectively.
In the above apparatus, the light quantity generator includes a multi-band pulsed light quantum generating unit that generates a multi-band pulsed light quantum, a continuous wave light quantum generating unit that generates a continuous wave light quantum, and an entangled-state light quantum pair generating unit that generates an entangled-state light quantum pair;
the optical quantum receiving antenna matrix comprises a multi-band pulse optical quantum receiving unit for receiving multi-band pulse optical quanta, a continuous wave optical quantum receiving unit for receiving continuous wave optical quanta and an entangled-state optical quantum receiving unit for receiving entangled-state optical quanta.
In the above apparatus, the optical quantum transmitting antenna matrix and the optical quantum receiving antenna matrix respectively include a plurality of optical quantum transmitting antennas and optical quantum receiving antennas that operate independently;
one or more photon transmitting antennas and one or more photon receiving antennas are arranged according to a certain rule to form a reusable photon transmitting and receiving antenna matrix, and each photon transmitting antenna and each photon receiving antenna are provided with a fixed code and a three-dimensional space coordinate; the antennas in the array are gated by a gating control matrix module.
The device also comprises a data correction module based on the knowledge base, and the data is corrected by adopting a leveling method based on the knowledge base.
The invention also provides a multi-channel brain function imaging method, which comprises the following steps:
step S10, selecting one or more antennas which are connected with the light quantum transmitting antenna matrix and the corresponding light quantum receiving antenna matrix according to the instruction of the central processing unit;
s20, emitting two paths of light quanta according to the instruction requirement of the central processing unit; one path is transmitted to the detected tissue through a transmitting antenna, and the other path is directly transmitted to a light quantum receiving module;
step S30, the photon receiving module receives one path of photon directly emitted by the photon generating and emitting module, and the other path of photon which is passed through the brain tissue to be detected and has changed state and count after being subjected to the actions of emission, refraction, scattering, absorption and photochemistry, and analyzes the state and count of the photon to obtain analyzable photon data, thermal activity data and bioelectricity data;
step S40, analyzing and calculating the analyzable light quantum data, the thermal activity data and the bioelectricity data to obtain the tissue component data of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue;
and step S50, executing the instruction of the central processing unit according to the components of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue, and reconstructing corresponding images.
The method comprises the steps of detecting an imaging active working mode and detecting an imaging passive working mode; wherein the content of the first and second substances,
the detection imaging active working mode is as follows: the central processing unit sends out an instruction, the photon generator generates entangled-state photons or non-entangled-state photons of continuous wave spectrum and pulse fixed wave spectrum, the photons are transmitted by the antenna transmitting matrix, pass through the detected tissue and are received by the photon receiving module, and then the tissue components and the final thermal activity and bioelectricity activity data of the tissue are obtained through calculation and analysis;
the detection imaging passive working mode is as follows: the central processing unit sends out an instruction, the photon receiving module receives an infrared signal and an electric activity signal which are radiated by a detected tissue due to one path of photon scanning, and then the infrared signal and the electric activity signal are calculated and analyzed to obtain tissue components and final thermal activity and bioelectricity activity data of the tissue.
The invention utilizes the characteristics of non-entangled light quantum of continuous wave spectrum and entangled light quantum of pulse wave spectrum to obtain the composition information, thermal activity, bioelectricity activity information and displacement information of human body tissue, and uses computer to assist imaging; has the following advantages:
(1) the optical quantum of the multi-band continuous spectrum is used, so that the resolution capability is high, and various tissue components can be analyzed by using an absorption spectrum;
(2) the detection depth is deeper, the light quantum can not be transmitted or absorbed in the reflection, refraction and scattering processes, and the state change of the light quantum can still be detected through the light quantum in an entangled state, so that all information of the state of the light quantum can be restored;
(3) the tissue composition data, the thermal activity data and the bioelectricity activity data are directly obtained, so that the measurement data are more direct and sensitive, and the use is more flexible and stable;
(4) the light quantum signal has no ferromagnetic compatibility problem, does not need radiography, and is safer and more reliable.
Drawings
Fig. 1 is a block diagram of a multi-channel brain function imaging device according to the present invention;
FIG. 2 is a block diagram showing the construction of a photon generator according to the present invention;
FIG. 3 is a block diagram of a photon receiving module according to the present invention;
FIG. 4 is a schematic diagram of an embodiment of a multiplexed optical quantum transmitting and receiving antenna matrix in accordance with the present invention;
FIG. 5 is a schematic diagram of the distribution of the multiplexed quantum transmitting and receiving antenna array in a helmet-type configuration;
FIG. 6 is a schematic diagram of the operation of a photon transmitter antenna or a photon receiver antenna in the present invention with a reusable transmitter and receiver antenna matrix, occurring in several test arrays simultaneously;
FIG. 7 is a flow chart of a multi-channel brain function imaging method according to the present invention;
FIG. 8 is a flowchart illustrating the operation of the detection imaging active mode of operation of the present invention;
fig. 9 is a flowchart of the operation of detecting the imaging passive operating mode in the present invention.
Detailed Description
Each molecule has a characteristic spectrum and a light transmission window, and the absorption resonance and scattering refraction characteristics for a specific wavelength are used as fingerprints for identifying the substance molecules. The invention adopts continuous wave spectrum and pulse wave spectrum to scan the detected tissue, and obtains the data of the composition, thermal activity, bioelectric activity and the like of the tissue, or uses pulse wave to position and measure the composition of specific tissue (such as brain tissue); the method is improved from the basic theory of information acquisition, and fully utilizes the non-entangled state photon and entangled state characteristic of the photon of continuous spectrum. The optical quantum pair A with the characteristic of the optical quantum entanglement state as the entanglement state consists of an optical quantum A1 and an optical quantum A2 which is in the entanglement state with the A1, the change of the state of the optical quantum A1 inevitably causes the change of the state of the other optical quantum A2, so that only one optical quantum A1 in the optical quantum pair A in the entanglement state is transmitted to the brain tissue to be detected, the optical quantum A1 is influenced by the components of the tissue to be detected (such as resonance absorption, Rayleigh scattering, Raman scattering, refraction, reflection and photochemical action), the state and other physical properties of the optical quantum A1 are changed, and the state data of the optical quantum A1 can be obtained by measuring the state of the optical quantum A2 which is in the entanglement state with the optical quantum A1, so as to obtain the components to be detected, the positions of the components to be detected, the thermodynamic data and the bioelectrical activity data of the tissue to be detected; the neuron activity is not estimated through oxygen consumption like fNIRS and fMRI, but thermodynamic activity data of the neurons are directly detected, and image reconstruction is completed.
The invention is described in detail below with reference to the figures and specific examples.
As shown in fig. 1, the multi-channel brain function imaging device provided by the invention is used for brain function imaging, tissue component analysis, brain function positioning and component positioning, and comprises a central processing unit, a light quantum generating and transmitting module, a light quantum receiving module, a gating control matrix module, a calculation and analysis module and an imaging module.
The central processing unit is used for sending out a photon generation instruction and a gating instruction;
and the light quantum generating and transmitting module correspondingly generates and transmits two paths of light quanta according to the light quantum generating instruction requirement of the central processing unit.
In the invention, the light quantum generating and emitting module comprises a light quantum modulation matrix unit, a light quantum generator, a light quantum splitter and a light quantum emitting antenna matrix. Wherein the content of the first and second substances,
the light quantum modulation matrix unit modulates and codes the frequency, power and waveform of the output light quantum according to a generation instruction sent by the central processing unit; the light quantum generator generates light quantum according to the modulation signal; the quantum splitter divides the light quantum generated by the generator into two paths; one path is transmitted to the detected brain tissue by one or more antennas in the light quantum transmitting antenna matrix, and the other path is directly transmitted to the light quantum receiving module.
And the light quantum receiving module is used for respectively receiving one path of light quantum directly sent by the light quantum generating and transmitting module, and the other path of light quantum which passes through the brain tissue to be detected and is subjected to the state and counting change after the brain tissue has the actions of transmission, refraction, scattering, absorption and photochemistry, and carrying out state detection on the state and counting of the light quantum to obtain corresponding analyzable light quantum data, thermal activity data and bioelectricity data.
The light quantum receiving module comprises a light quantum receiving antenna matrix, a light quantum state detection unit, a light quantum signal amplification unit, a light quantum signal demodulation and decoding unit, a digital-to-analog conversion unit and a digital filtering unit.
One or more antennas in the optical quantum receiving antenna matrix receive one path of optical quantum directly transmitted by the optical quantum generating and transmitting module, and the other path of optical quantum which passes through the detected brain tissue and is subjected to the state and counting change after the reflection, refraction, scattering, absorption and photochemical action of the brain tissue, the state detection is carried out on the two paths of optical quantum by the optical quantum state detection unit, and the analyzable optical quantum data, the thermal activity data and the bioelectricity data of the detected tissue are obtained through the amplification, demodulation and decoding, the digital-to-analog conversion and the filtering of the optical quantum signal amplification unit, the optical quantum signal demodulation and decoding unit, the digital-to-analog conversion unit and the filtering unit.
And the gating control matrix module is used for selectively switching on one or more light quantum transmitting or receiving antennas of the light quantum generating and transmitting module or the light quantum receiving module according to a gating instruction of the central processing unit.
And the calculation analysis module is used for analyzing and calculating the received analyzable light quantum data, thermal activity data and bioelectricity data to obtain the detected tissue component data, the final thermal activity data and bioelectricity activity data of the detected tissue and the like.
In the invention, the calculation and analysis module comprises a photon statistics physics calculation unit, a photon energy spectrum analysis and statistics unit, a photon absorption resonance analysis unit, a scattering analysis unit (comprising a Raman scattering analysis unit, a Rayleigh scattering analysis unit and the like), a photon differential analysis unit and a photon differential Doppler analysis unit.
The light quantum absorption resonance analysis unit and the scattering analysis unit analyze and calculate the absorption spectrum and the scattering spectrum of the detected tissue to the incident light quantum by utilizing the analyzable thermal activity and bioelectricity activity data of the detected tissue.
And the light quantum energy spectrum analysis statistical unit is used for carrying out energy spectrum analysis calculation on the received analyzable light quantum data.
And the photon statistics physics calculation unit is used for carrying out statistics analysis on the calculation results of the absorption resonance unit, the scattering analysis unit and the photon energy spectrum analysis and statistics unit so as to analyze and obtain the component data of the detected tissue and the final thermal activity data, the final bioelectricity activity data and the like of the detected tissue.
The light quantum differential analysis unit and the light quantum differential Doppler analysis unit analyze and calculate the blood flow velocity or the moving velocity of specific components such as lymphocytes and medicinal components.
And the imaging module executes the instructions of the central processing unit according to the component data of the detected tissue, the final thermal activity data, the final bioelectric activity data and the like of the detected tissue and is sent by the calculation and analysis module to perform corresponding imaging.
The imaging module comprises a data correction module and a reconstruction imaging module, the data correction module corrects the received component data of the detected tissue and the final thermal activity and bioelectricity activity data of the tissue, and the reconstruction imaging module performs image reconstruction by using the corrected component data of the detected tissue and the thermal activity and bioelectricity activity data of the tissue according to the instruction of the central processing unit.
In the invention, the light quantum generation and emission mode generation, and the emitted light quantum comprises three conditions of non-entangled light quantum, entangled light quantum pair, non-entangled light quantum and entangled light quantum pair.
(1) For the condition that only non-entangled-state light quanta exist, one path of the light quanta is emitted to the detected brain tissue by a light quanta generating and emitting module, the state of the light quanta is changed by the absorption, reflection, refraction, scattering and photochemical action of the detected brain tissue, the thermal activity and the bioelectrical activity of the detected brain tissue are changed under the photochemical action, the light quanta with the changed state of the detected brain tissue and the thermal activity and bioelectrical activity signals of the detected brain tissue are received by a light quanta receiving module, and state detection, amplification, demodulation, decoding, digital-to-analog conversion and filtering are carried out to obtain analyzable light quanta data, thermal activity data and bioelectrical data; the other path of non-entangled state light quantum is directly sent to a light quantum receiving module as a contrast signal for state detection, amplification, demodulation and decoding, digital-to-analog conversion and filtering to obtain analyzable standard light quantum data; the calculation analysis module is used for comparing and calculating analyzable light quantum data and standard light quantum data and analyzing and calculating analyzable light quantum data, analyzable thermal activity data and bioelectricity data to obtain composition data, final thermal activity data, final bioelectricity data and the like of the tested tissue.
(2) For the condition that only the entangled-state photon pair exists, the photon generation and emission module emits one photon (seen as one path) in the entangled-state photon pair to the detected brain tissue as a probe; the other optical quantum (regarded as the other path) in the entangled-state optical quantum pair is directly sent to the optical quantum receiving module as a shadow measurement probe, and the optical quantum receiving module carries out state detection, amplification, demodulation and decoding, digital-to-analog conversion and filtering on the entangled-state optical quantum directly sent to the optical quantum receiving module to obtain analyzable optical quantum data; the calculation analysis module obtains the composition data of the tested tissue, the final thermal activity data, the bioelectricity data and the like by calculating and analyzing the analyzable light quantum data.
(3) For the conditions of the non-entangled-state photon pairs and the entangled-state photon pairs, the photon generation and emission module, the photon receiving module and the calculation and analysis module respectively process the non-entangled-state photon pairs or the entangled-state photon pairs according to the processing mode; and the calculation analysis module carries out statistics on the obtained component data of the tested tissue, the final thermal activity data and the bioelectricity data respectively.
In the present invention, as shown in FIG. 2, the light quantity generator includes a multiband pulsed light quantum generating unit that generates multiband pulsed light quanta, a continuous wave light quantum generating unit that generates continuous wave light quanta, and an entangled-state light quantum pair generating unit that generates entangled-state light quantum pairs.
Accordingly, as shown in fig. 3, the optical quantum receiving module includes a multiband pulsed optical quantum receiving unit that receives multiband pulsed optical quanta, a continuous wave optical quantum receiving unit that receives continuous wave optical quanta, and an entangled-state optical quantum receiving unit that receives entangled-state optical quanta.
In the invention, the light quantum transmitting antenna matrix and the light quantum receiving antenna matrix respectively comprise a plurality of light quantum transmitting antennas and light quantum receiving antennas which can work independently; in the invention, a plurality of light quantum transmitting antennas can independently form a light quantum transmitting antenna matrix, and a plurality of light quantum receiving antennas can independently form a light quantum receiving antenna matrix; or one or more photon transmitting antennas and one or more photon receiving antennas are arranged according to a certain rule to form a reusable photon transmitting and receiving antenna matrix, and each photon transmitting antenna and each photon receiving antenna have a fixed code and a three-dimensional space coordinate; the antennas in the array are gated by a gating control matrix module.
As shown in fig. 4, in an embodiment of a reusable optical quantum transmitting and receiving antenna matrix, black dots represent transmitting antennas, white dots represent receiving antennas, and the (X, Y) coordinate is (3, 3) as the center of the transmitting antennas, a 3X3, 5X5 … nXn reusable optical quantum transmitting and receiving antenna matrix can be formed, but is not limited to the arrangement, as long as at least one transmitting antenna and at least one receiving antenna are ensured; as shown in fig. 5, when the reusable optical quantum transmitting and receiving antenna matrix (detection matrix) works in the form of a helmet, the spatial coordinates of each receiving and transmitting antenna are relatively fixed, the optical quantum is transmitted by the transmitting antenna-3 in fig. 5, the optical quantum is subjected to resonance absorption, refraction, various scattering (including but not limited to rayleigh scattering, raman scattering, thomson scattering, compton scattering), and part of the optical quantum reaches the receiving antennas 1, 4, -2 (including but not limited to the 3 receiving antennas), and according to the three-dimensional coordinates of the transmitting antenna and the coordinates of the receiving antennas, the coordinates of the region position of black dispersion curve in fig. 5 can be obtained by using the mathematical principle, that is, the region of the lesion can be obtained, and the coordinate data information can be displayed in the reconstructed image.
The "transmit and receive antenna matrix" receive antenna multiplexing as shown in fig. 4 is instructed by the central processor module of fig. 1 to determine the number of the multiplexed antennas (receive and transmit antennas).
Fig. 6 shows an operation mode of a multiplexing transmitting and receiving antenna array, in which the optical quantum transmitting antenna forms an optical quantum transmitting antenna array, that is, No. 0, No. 3, and No. 6 form a multiplexing optical quantum transmitting antenna array, the transmitting antenna array can be used for differential analysis and differential doppler analysis, and other non-exemplified applications, fig. 6 illustrates that the optical quantum transmitting antenna or the optical quantum receiving antenna can simultaneously appear in several test arrays, and gating is controlled by a gating control matrix, for example, fig. 6 can form a test array Z1 by No. 1 and No. 2, can form a test array Z2 by No. 1 and No. 2 and No. 4, or can form a test array Z3 by No. 2 and No. 3 and No. 4 and No. 6, or can form a test array Z4 by No. 4 and No. 6.
The data correction module based on the knowledge base corrects data by adopting a correction method based on the knowledge base, and overcomes the noise filtering defect based on statistics.
As shown in fig. 7, the present invention provides a multi-channel brain function imaging method, comprising the steps of:
and step S10, the gating control matrix module selects and connects one or more antennas of the light quantum generating and transmitting module and the light quantum receiving module according to the instruction of the central processing unit.
Step S20, the light quantum generating and emitting module emits two paths of light quanta according to the instruction requirement of the central processing unit; one path is transmitted to the detected tissue through the transmitting antenna, and the other path is directly transmitted to the light quantum receiving module.
Step S30, the light quantum receiving module receives one path of light quantum directly emitted by the light quantum generating and emitting module, and the other path of light quantum which is changed in state and count after passing through the detected brain tissue and being subjected to the actions of emission, refraction, scattering, absorption and photochemistry, and the state and count of the light quantum are analyzed to obtain analyzable light quantum data, thermal activity data and bioelectricity data.
And step S40, analyzing and calculating the analyzable light quantum data, the thermal activity data and the bioelectricity data to obtain the detected tissue component data and the detected tissue thermal activity and bioelectricity activity data.
And step S50, executing a central processing unit instruction according to the components of the detected tissue and the final thermal activity data and bioelectrical activity data, and reconstructing corresponding images.
In the invention, an imaging active working mode and an imaging passive working mode are detected. Wherein the content of the first and second substances,
the detection imaging active working mode is that a central processing unit sends out an instruction, a photon generator generates entangled-state photons or non-entangled-state photons of continuous wave spectrum and pulse fixed wave spectrum, the photons are emitted by an antenna emitting matrix, pass through the detected tissue and are received by a photon receiving module, and then the data of the detected tissue is calculated and analyzed to obtain the component data of the detected tissue and the final thermal activity and bioelectrical activity data of the detected tissue.
The detection imaging passive working mode is that a central processing unit sends out an instruction, a photon receiving module receives a thermal activity signal and a bioelectricity activity signal which are radiated by a detected tissue due to scanning of one photon, and then the thermal activity signal and the bioelectricity activity signal are calculated and analyzed to obtain tissue component data, final thermal activity data and final bioelectricity activity data. The photon generator in the detection imaging passive working mode does not work, and the quantity of information acquired in the detection imaging passive working mode is less than that in the active working mode.
In the present invention, as shown in fig. 8, the detection imaging active working mode specifically includes the following steps:
step 101, the central processing unit sends out an active detection instruction and a multiplexing coordinate of the transmitting antenna.
Step 102, the optical quantum modulation matrix module gives optical quantum modulation parameters and optical quantum entanglement states, wherein the optical quantum modulation parameters comprise frequency, power (optical quantum number) and waveform.
Step 103, the photon generator generates non-entangled state photons or entangled state photons pairs of continuous spectrum or pulse spectrum.
And step 104, splitting by the optical splitter, wherein one optical quantum in the entangled state quantum pair enters the optical quantum transmitting antenna, and the other optical quantum enters the optical quantum receiving module.
And 105, gating the optical quantum transmitting antenna by the gating control matrix module according to the transmitting antenna multiplexing coordinate sent by the central processing unit.
And 106, emitting the light quanta by the light quanta emitting antenna matrix.
And step 107, the light quantum receiving antenna sent by the central processing unit multiplexes the coordinate gating light quantum receiving antenna to receive the light quantum signal.
Step 108, the state detection module detects the photon state.
Step 109, amplifying, demodulating and analog-to-digital converting the optical quantum signal, and converting the analog signal into a digital signal.
Step 110, the digital filtering module filters out noise and unwanted signals.
And step 111, calculating and analyzing the digital signals to obtain the components of the detected tissues and the final thermal activity and bioelectrical activity data.
And step 112, carrying out visual image reconstruction according to the components of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue.
Wherein, the step 111 comprises photon statistics physics calculation, photon energy spectrum analysis calculation, photon absorption spectrum calculation, scattering analysis calculation, differential Doppler analysis calculation and differential analysis calculation. And finally, correcting the data deviation of the calculation result on the basis of a knowledge base.
In the present invention, as shown in fig. 9, a flowchart of a passive working mode of detection imaging is described, where the flowchart describes that, in a case where no optical quantum signal is actively emitted, infrared radiation, i.e. thermal activity, is emitted by passively examining a tissue due to one path of optical quantum scanning, and the infrared radiation is also one type of optical quantum radiation, and specifically includes the following steps:
step 201, the central processing unit emits light quantum to output multiplexing coordinates of the receiving antenna.
Step 202, gating the optical quantum receiving antenna by the gating control matrix.
And step 203, receiving the optical quantum signals by the receiving antenna matrix.
And step 204, amplifying the optical quantum signals and converting the optical quantum signals into digital signals.
And step 205, performing digital filtering on the electric signal.
And step 206, performing photon statistics physics calculation and energy spectrum calculation.
And step 207, correcting the data deviation based on the knowledge base.
And step 208, drawing the digital image according to the calculation result.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. A multi-channel brain function imaging device, comprising:
the central processing unit is used for sending out a photon generation instruction and a gating instruction;
the light quantum generating and emitting module correspondingly generates and emits two paths of light quanta according to the requirement of a light quantum generating instruction of the central processing unit, and comprises a light quantum generator, wherein the light quanta generated by the light quantum generator comprise a multi-band pulse light quantum, a continuous wave light quantum and an entangled-state light quantum pair;
the light quantum receiving module is used for respectively receiving one path of light quantum directly sent by the light quantum generating and transmitting module and the other path of light quantum which passes through the detected brain tissue and is subjected to the change of state and counting of the brain tissue after reflection, refraction, scattering, absorption and photochemical action, and analyzing the state and counting of the light quantum to obtain correspondingly analyzable light quantum data, thermal activity data and bioelectricity activity data;
the gating control matrix module is used for selectively switching on one or more light quantum transmitting or receiving antennas of the light quantum generating and transmitting module or the light quantum receiving module according to a gating instruction of the central processing unit;
the calculation analysis module is used for analyzing and calculating the received analyzable light quantum data, thermal activity data and bioelectricity activity data to obtain component data of the detected tissue and final thermal activity data and bioelectricity activity data of the detected tissue;
and the imaging module executes the instruction of the central processing unit according to the component data of the detected tissue sent by the calculation and analysis module and the final thermal activity and bioelectricity activity data of the detected tissue, and performs corresponding visual image reconstruction.
2. The apparatus of claim 1, wherein the optical quantum generating and emitting module is composed of an optical quantum modulation matrix unit, an optical quantum generator, an optical quantum splitter, an optical quantum emitting antenna matrix; wherein the content of the first and second substances,
the light quantum modulation matrix unit modulates and codes the frequency, power and waveform of output light quantum according to a generation instruction sent by the central processing unit; the light quantum generator generates light quantum according to the modulation signal; the light quantum splitter divides the light quantum generated by the light quantum generator into two paths; one path is transmitted to the detected brain tissue by one or more antennas in the light quantum transmitting antenna matrix, and the other path is directly transmitted to the light quantum receiving module.
3. The apparatus of claim 2, wherein the optical quantum receiving module comprises an optical quantum receiving antenna matrix, an optical quantum state detecting unit, an optical quantum signal amplifying unit, an optical quantum signal demodulating and decoding unit, a digital-to-analog converting unit and a digital filtering unit; wherein the content of the first and second substances,
one or more antennas of the optical quantum receiving antenna matrix receive one path of optical quantum which is directly generated by the optical quantum generation and emission module, and the other path of optical quantum which is subjected to the brain tissue detection and is changed in state and count after being reflected, refracted, scattered, absorbed and photochemical, and the state of the optical quantum is detected by the optical quantum state detection unit, and the optical quantum is amplified, demodulated, decoded, converted and filtered by the optical quantum signal amplification unit, the optical quantum signal demodulation and decoding unit, the digital-to-analog conversion unit and the digital filtering unit to obtain analyzable optical quantum data, thermal activity data and bioelectricity data.
4. The apparatus of claim 1, wherein the computational analysis module comprises a photon statistics physics computational unit, a photon energy spectrum analysis statistical unit, a photon absorption resonance analysis unit and scattering analysis unit, a photon differential analysis unit, and a photon differential doppler analysis unit;
the photon absorption resonance analysis unit and the scattering analysis unit analyze and calculate the absorption spectrum and the scattering spectrum of the detected tissue to the incident photons by utilizing the analyzable thermal activity and bioelectricity activity data of the detected tissue;
the light quantum energy spectrum analysis statistical unit is used for carrying out energy spectrum analysis calculation on the received analyzable light quantum data;
the photon statistics physics calculation unit is used for carrying out statistics analysis on the calculation results of the photon absorption resonance analysis unit, the scattering analysis unit and the photon energy spectrum analysis and statistics unit to obtain the component data of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue;
the light quantum differential analysis unit and the light quantum differential Doppler analysis unit analyze and calculate blood flow velocity or brain tissue.
5. The apparatus as claimed in any one of claims 1-4, wherein the optical quantum emitted by the optical quantum generating and emitting module comprises three cases of non-entangled state optical quantum, entangled state optical quantum pair, and non-entangled state optical quantum and entangled state optical quantum pair;
for the condition that only non-entangled-state light quanta exist, one path of the light quanta is transmitted to the detected brain tissue by the light quanta generating and transmitting module, the state of the light quanta is changed by absorption, reflection, refraction, scattering and photochemical action of the detected brain tissue, the thermal activity and the bioelectrical activity of the detected brain tissue are changed under the photochemical action, the light quanta with the changed state of the detected brain tissue and the thermal activity and bioelectrical activity signals of the detected brain tissue are received by the light quanta receiving module, and state detection, amplification, demodulation, decoding, digital-to-analog conversion and filtering are carried out to obtain analyzable light quanta data, thermal activity data and bioelectrical data; the other path of non-entangled state light quantum is directly sent to a light quantum receiving module as a contrast signal for state detection, amplification, demodulation and decoding, digital-to-analog conversion and filtering to obtain analyzable standard light quantum data; the calculation analysis module is used for comparing and calculating analyzable light quantum data and standard light quantum data and analyzing and calculating analyzable light quantum data, analyzable thermal activity data and bioelectricity data to obtain component data, final thermal activity data and final bioelectricity data of the tested tissue;
for the case of only entangled-state photon pairs, the photon generation and emission module emits one photon of the entangled-state photon pairs to the detected brain tissue; the other optical quantum in the entangled-state optical quantum pair is directly sent to an optical quantum receiving module, and the optical quantum receiving module carries out state detection, amplification, demodulation and decoding, digital-to-analog conversion and filtering on the entangled-state optical quantum directly sent to the optical quantum receiving module to obtain analyzable optical quantum data; the calculation analysis module is used for calculating and analyzing the analyzable light quantum data to obtain component data, final thermal activity data and bioelectricity data of the detected tissue;
for the conditions of the non-entangled-state photon pairs and the entangled-state photon pairs, the photon generation and emission module, the photon receiving module and the calculation and analysis module respectively process the non-entangled-state photon pairs or the entangled-state photon pairs according to the processing mode; and the calculation analysis module is used for counting the obtained component data of the tested tissue, the final thermal activity data and the bioelectricity data respectively.
6. The apparatus of claim 3, wherein the light quantity generator includes a multiband pulsed light quantum generating unit that generates multiband pulsed light quanta, a continuous wave light quantum generating unit that generates continuous wave light quanta, and an entangled-state light quantum pair generating unit that generates entangled-state light quantum pairs;
the optical quantum receiving antenna matrix comprises a multi-band pulse optical quantum receiving unit for receiving multi-band pulse optical quanta, a continuous wave optical quantum receiving unit for receiving continuous wave optical quanta and an entangled optical quantum pair receiving unit for receiving entangled optical quantum pairs.
7. The apparatus of claim 3, wherein the optical quantum transmitting antenna matrix and the optical quantum receiving antenna matrix each comprise a plurality of optical quantum transmitting antennas and optical quantum receiving antennas operating independently;
one or more photon transmitting antennas and one or more photon receiving antennas are arranged according to the serial number sequence to form a reusable photon transmitting and receiving antenna matrix, and each photon transmitting antenna and each photon receiving antenna are provided with a fixed code and a three-dimensional space coordinate; the antennas in the array are gated by a gating control matrix module.
8. The apparatus of claim 1, further comprising a knowledge-base based data correction module that corrects the data using a knowledge-base based adjustment method.
9. A method of multi-channel brain function imaging, comprising the steps of:
step S10, selecting one or more antennas which are connected with the light quantum transmitting antenna matrix and the corresponding light quantum receiving antenna matrix according to the instruction of the central processing unit;
s20, emitting two paths of light quanta according to the instruction requirement of the central processing unit; one path is transmitted to a detected tissue through a transmitting antenna, and the other path is directly transmitted to a light quantum receiving module, wherein the light quantum comprises a multi-band pulse light quantum, a continuous wave light quantum and an entangled-state light quantum;
step S30, the light quantum receiving module receives one path of light quantum directly emitted by the light quantum generating and emitting module, and the other path of light quantum which changes in state and count after passing through the detected brain tissue and being subjected to reflection, refraction, scattering, absorption and photochemical action of the brain tissue, and analyzes the state and count of the light quantum to obtain analyzable light quantum data, thermal activity data and bioelectricity data;
step S40, analyzing and calculating the analyzable light quantum data, the thermal activity data and the bioelectricity data to obtain the tissue component data of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue;
and step S50, executing the instruction of the central processing unit according to the components of the detected tissue and the final thermal activity and bioelectricity activity data of the detected tissue, and reconstructing corresponding images.
10. The method of claim 9, including detecting an imaging active mode of operation and detecting an imaging passive mode of operation; wherein the content of the first and second substances,
the detection imaging active working mode is as follows: the central processing unit sends out an instruction, the photon generator generates entangled-state photons or non-entangled-state photons of continuous wave spectrum and pulse fixed wave spectrum, the photons are transmitted by the antenna transmitting matrix, pass through the detected tissue and are received by the photon receiving module, and then the tissue components and the final thermal activity and bioelectricity activity data of the tissue are obtained through calculation and analysis;
the detection imaging passive working mode is as follows: the central processing unit sends out an instruction, the photon receiving module receives a thermal activity signal and a bioelectricity activity signal of a detected tissue radiated by a photon scanning, and then the thermal activity signal and the bioelectricity activity signal are calculated and analyzed to obtain tissue components and final thermal activity and bioelectricity activity data of the tissue.
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