CN102327111A - Multichannel near-infrared brain functional imaging parallel detection system - Google Patents
Multichannel near-infrared brain functional imaging parallel detection system Download PDFInfo
- Publication number
- CN102327111A CN102327111A CN201110286531A CN201110286531A CN102327111A CN 102327111 A CN102327111 A CN 102327111A CN 201110286531 A CN201110286531 A CN 201110286531A CN 201110286531 A CN201110286531 A CN 201110286531A CN 102327111 A CN102327111 A CN 102327111A
- Authority
- CN
- China
- Prior art keywords
- signal
- detection
- light
- optical fiber
- optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention belongs to the field of optical parameter measurement in tissue optical research, and relates to a multichannel near-infrared brain functional imaging parallel detection system, which comprises a light source part, a brain detection part, a detector part, a multifunctional number phase locking detection circuit and a computer. The light source part comprises a plurality of light source units, each group of unit comprises two steady state semiconductor lasers with different wave lengths, digital-to-analogue conversion and filter circuits and current controllers of the two steady state semiconductor lasers, a wavelength division multiplexer and light optical fibers, wherein the light which is produced by the two lasers driven by the current controllers thereof passes by the wavelength division multiplexer, and then passes by the light optical fibers to be fed to the brain detection part; the brain detection part comprises a plurality of optical seats, and the optical seats are connected with one another through link belts to form a netty passage; and all the light optical fibers are connected onto different optical seats. The invention combines the single photon counting technology with the phase locking detection technology, not only the quick imaging requirement is benefited, but also the wide dynamic range requirement is satisfied.
Description
Technical field
The present invention relates to the optical imaging system in the human body information detection range, be specifically related to a kind of implement device of the multicenter near-infrared imaging system that is used for brain function research of the digital lock-in technique based on single photon counting.
Technical background
Having very important significance in body research of brain function, its application relates to scientific research and clinical diagnosis and treatment.
The non-invasive methods of research brain function mainly comprises function nuclear magnetic resonance, NMR (fMRI) and positron emission imaging (PET), electroencephalogram (EEG), event related potential (ERP) and magneticencephalogram (MEG) and optical imaging method (NIRS) at present.NIRS adopts the light of two above wavelength (in the 600-900nm wave band) in the presumptive area of scalp, to carry out the multiple spot irradiation; Because the degree of depth penetration capacity of near infrared light; And reflection brain tissue metabolism and hemodynamic HbO2 Oxyhemoglobin (HbO) and reduced hemoglobin (Hb) be the interior main absorber of near infrared light wave band just; Surveying light apart from several centimeters of point of irradiation by the scalp outgoing; Because emergent light has carried the HbO of cortex and the information of Hb concentration change, can provide the HbO of cortex and the spatial distribution map of Hb concentration change through algorithm, thereby realize the research of brain function or the diagnosis of disease.
Than other cerebral function imaging method, the NIRS equipment price is lower, and volume is urinated in moving, and has very high temporal resolution and higher spatial resolution.Whenever it can be implemented in, Anywhere, for a long time, cerebral function imaging repeatedly; The more important thing is because its probe is fixed on head; Imaging is as coordinate with head itself; Therefore have very high subjects's motion robustness, it also is a present unique cerebral function imaging instrument that can be applied to the baby.Because the above-mentioned advantage of NIRS, it has become the advanced method of brain function research, sports medical science research.Through development progressively, the CW series of ETG system that HIT becomes to produce and TechEn company and the cooperative development of Massachusetts medical college has occupied than consequence.
Wherein how to improve spatial resolution and become key issue.From the angle of measuring, the effective ways that improve image spatial resolution are to improve sampling density, when detection range can not reduce, make the overlapping the only resource that improves sampling density that then becomes of sample area.But, make the overlapping also not a duck soup of sample area for the NIRS measuring system.Improving the dynamic range of measuring passage is to improve the key point of NIRS system space resolution.For the ETG system that avoids the little problem HIT of measuring system dynamic range has increased the number of source point and sensing point, but what bring thus is the complexity and the high price of system.And the CW5 system has adopted timesharing to open the method for light source, but can only survey the light within the 19-42.5mm, and the temporal resolution of system descends greatly.
Therefore, we see that the spatial resolution problem that improves the NIRS system summed up in the point that the dynamic that improves detection system.And the dynamic range that improves system is that existing metering system is beyond one's reach, and should take new technique.
Patent CN201010161237.X discloses a kind of multi-channel single photon counting measuring system based on digital lock phase de-multiplex; Single-photon counting method utilizes the low light level irradiation discrete naturally characteristics of the photon detector output signal of telecommunication down, and technology is screened in the employing pulse and the digital counting technology is discerned extremely weak signal and extract.With the analog detection compared with techniques, the single photon counting technology has following advantage: eliminated the influence of most of thermal noise of detector, improved the signal to noise ratio of measurement result greatly; Linear dynamic range than broad is arranged.Phase Lock Technique can be extracted buried useful signal in noise, can improve signal to noise ratio.And, then have big detection dynamic range and high signal to noise ratio based on the digital phase-locking phase detection technique of single photon counting.
Summary of the invention
For overcoming the prior art deficiency, the present invention provides a kind of the have dynamic range of higher measurement passage and brain function near infrared light imaging (NIRS) system of spatial resolution.Brain function near infrared light imaging (NIRS) system that the present invention proposes; Employing is calculated the method for cerebral blood oxygen saturation based on the digital phase-locking phase detection technique of single photon counting with utilizing diffusion equation, is near infrared light imaging (NIRS) system that a kind of multi-channel parallel detects.Technical scheme of the present invention is following:
A kind of multichannel Near-infrared Brain functional imaging parallel detection system comprises the Lights section, probe part, explorer portion, multi-channel digital phase-lock detecting circuit and computer.Wherein,
Described the Lights section comprises the multiple sets of light sources unit; Every group of unit comprises the stable state semiconductor laser of two different wave lengths and separately digital-to-analogue conversion and filter circuit and current controller; Wavelength division multiplexer and source optical fiber; The modulated-analog signal that obtains after the processing of modulation of source signal through digital-to-analogue conversion and filter circuit is as the input of current controller, and two laser instrument are sent into probe part through source optical fiber in the driving of separately current controller after the light of generation passes through wavelength division multiplexer down;
Described probe part comprises a plurality of fiber bench, and each fiber bench links to each other through connecting band, constitutes a netted path; Each source optical fiber is connected on the different fibers seat;
Described detector comprises many group detector cells; Each detector cells comprises detection optical fiber, filtering wheels, photomultiplier tube, pulse examination and integer circuit; One end of described detection optical fiber is connected on the fiber bench; The other end is connected to the filtering wheels, obtains voltage pulse signal after the processing of optical signal through photomultiplier tube and pulse examination and integer circuit of filtering wheels output; Each detection optical fiber is connected respectively on the different fibers seat;
Described multi-channel digital phase-lock detecting circuit; Comprise top layer control logic circuit, amplitude demodulation module, cosine and sine signal generator module; Under the control of top layer control logic circuit; Produce digital cosine and sine signal by the cosine and sine signal generator module, as lock phase reference signal detection and the needed modulation of source signal of the Lights section, the amplitude demodulation module is according to lock phase reference signal detection; Plurality of voltages pulse signal to detector output carries out frequency division multiplexing synchronous demodulation, and the signal of process synchronous demodulation is admitted to computer;
Described computer obtains cerebral blood oxygen saturation according to the synchronous demodulation signal of multi-channel digital phase-lock detecting circuit input, and realizes cerebral function imaging.
As further embodiment, described multichannel Near-infrared Brain functional imaging parallel detection system, each is organized light source cell and forms by two groups of stable state semiconductor lasers of wavelength 690nm and 830nm; The frequency that each stable state semiconductor laser is produced has nothing in common with each other.
Can find out that by technique scheme main feature of the present invention is embodied in:
(1) based on the continuous wave detection mode; Light source adopts monochromatic near infrared light continuously; Continuous wave detection mode real-time is good, and speed is fast, and signal to noise ratio is high; In the time of can surveying cerebration simultaneously fast (after the stimulation incident 50～500ms) with slow (2～10s) change procedures after the stimulation incident, thus guarantee temporal resolution.
(2) adopt light source frequency division multiplexing, multiple signals digital lock phase de-multiplex method, the luminous intensity measurement when being implemented in multiple light courcess and encouraging simultaneously, it is long to have overcome multiple light courcess time-division multiplexing method Measuring Time, and passage switches the shortcoming of generation error, has simplified system's formation.
(3) detection technique combines the single photon counting technology with locking mutually, has both helped the needs of fast imaging, can satisfy the requirement of great dynamic range again.
Description of drawings
Fig. 1: measuring system block diagram.
Fig. 2: light-source system block diagram.
Fig. 3: self adaptation probe part.
Fig. 4: explorer portion block diagram.
The specific embodiment
The invention provides a kind of multicenter near-infrared parallel detection system that is used for cerebral function imaging,, thereby when improving the measurement dynamic range, satisfy the requirement of brain function research high time resolution in conjunction with single photon counting technology and digital phase-locking detection technique mutually.
The present invention proposes the NIRS system of the multi-channel parallel detection of suitable brain function research, and composition frame chart is seen Fig. 1, comprises the Lights section, self adaptation probe part, explorer portion, data acquisition and first processing section, computer.
The present invention adopts the source of 24*32 to visit position distribution, and multichannel light source frequency division multiplexing combines with the demodulation of multi-channel digital lock synchronised, realizes that homology is not visited the combination synchronous detecting of output intensity signal down.The Lights section is made up of two groups of stable state semiconductor lasers of wavelength 690nm and 830nm, 24 every group, adopts the sinusoidal signal of 48 road different frequencies to make the low frequency Modulation and Amplitude Modulation.The near infrared light of output is pressed the wavelength difference and is realized frequency division multiplexing through the wavelength division multiplexer coupling in twos, imports to 24 source point positions that are distributed in self adaptation side head through incident optical afterwards, as the pumping signal of Near-infrared Brain Function detection.
The self adaptation probe part with reference to the EEG electrode cap design and make improvements.With connecting band fiber bench is coupled together, consider the thickness of adult's scalp and skull, the distance employing 30mm between the two adjacent fiber bench.Through spring fiber bench is pressed on the scalp, source optical fiber and detection optical fiber are connected on the fiber bench through the SMA fibre-optical splice.
Comprising of explorer portion: detection optical fiber, filtering wheels, photomultiplier tube, pulse examination and integer circuit; Wherein the filtering wheels be used to adjust be input to photomultiplier tube light intensity; Guarantee not homology visit distance down photomultiplier tube all work in the single photon counting state, thereby improve the dynamic range of measuring.The photosignal conversion is realized in this part, and output changes with the input light intensity, shows as the different normal voltage pulse signal of frequency.
Data acquisition comprises multi-channel digital phase-lock detecting circuit, digital-to-analogue conversion and filter circuit and telecommunication circuit with first processing section.Wherein, the multi-channel digital phase-lock detecting circuit is the core of this part, realizes the synchronous demodulation of frequency division multiplexing multichannel light signal; Digital-to-analogue conversion and filter circuit are responsible for producing the analog sinus signals of modulated laser source; Communications portion is in order to accomplish the mutual of this part and computer.
Interactive interface between computer realization and the operator is used to control the duty of whole measuring system, and is responsible for converting data acquisition into cerebral blood oxygen saturation with just handling the result who produces, and realizes final cerebral function imaging.
Describe in the face of each ingredient down.
One, the Lights section is in order to produce amplitude-modulated near infrared light, as the pumping signal of imaging system.See Fig. 2 light-source system block diagram.Comprise with the lower part
1. digital-to-analogue conversion and filter circuit: the digital sine conversion of signals that the cosine and sine signal generator module is produced becomes analog sinus signals and does conditioning, is met the modulated-analog signal of LD controller requirement.
2.LD current controller:, realize amplitude modulation(PAM) to the LD emergent light according to the drive current of the modulated-analog signal adjustment laser tube of importing;
3.LD temperature controller: the temperature stabilization when keeping LD work, guarantee to export Wavelength of Laser and remain unchanged;
4. laser diode: under the drive current effect, produce the laser of specific wavelength, native system adopts the laser tube of 690nm and two kinds of wavelength of 830nm;
5. wavelength division multiplexer: the LMDS Light Coupled Device for dual input, single channel output, be used for different wavelength of laser is coupled to a branch of optical fiber in twos, form composite light source.
Two, self adaptation probe part is like Fig. 3.
1. this gauge head is carried out to picture to prefrontal lobe, motor function district, the occipital region, back of human brain.Adopt 24 source points and 32 sensing points altogether, each source point and sensing point are installed a source optical fiber and a detection optical fiber respectively.
2. the detection to forehead utilizes 8 source points and 8 sensing points to accomplish; Left and right motor function district adopts 7 source points and 7 sensing points to accomplish respectively; The detection of back occipital region adopts 2 source points and 8 sensing points to accomplish.
Three, explorer portion is like Fig. 4.
1. filtering wheels: be used for adjustment and be input to photomultiplier tube and get light intensity, guarantee that photomultiplier tube works in the single photon counting state.
2. photomultiplier tube: realize the critical component of opto-electronic conversion, under the situation of faint light input, be output as discrete potential pulse.
3. pulse examination and integer circuit: the electric pulse to photomultiplier tube output is screened and integer, obtains the voltage pulse signal of rule, offers back grade data collection and does further processing with first processing section.
Four, data acquisition and just processing section.
This part is a core with FPGA, has realized multi-channel digital phase-lock detecting circuit, digital-to-analogue conversion and filter circuit and telecommunication circuit.Concrete realization can be referring to CN201010161237.X
1. digital phase-locking phase detecting circuit in multichannel road comprises top layer control logic, amplitude demodulation module, cosine and sine signal generator module, data transmission blocks, communication interface modules for realizing the key of frequency division multiplexing light signal demodulation.
A) wherein the top layer control logic is controlled the rhythm of whole digital circuit each several part work, and is responsible for and computer interactive obtains the operational factor of measuring process;
B) the cosine and sine signal generator module is responsible for producing digital cosine and sine signal, as lock phase reference signal detection and modulation of source signal;
C) the amplitude demodulation module realizes input signal and reference signal mixing, promptly the frequency division multiplexing light source is carried out demodulation;
D) data transmission blocks is used to coordinate each passage demodulation result and sends it back computer in order;
E) communication interface modules is realized the driving signal of PERCOM peripheral communication chip, be responsible for and computer between the acceptance and the transmission of data.
2. telecommunication circuit: the hardware circuit of accomplishing data interaction between multi-channel digital phase-lock detecting circuit and the computer.
Five, user interface and Data Post part
1. user interface handled easily person using system is controlled the duty of whole measuring system through sending order;
2. Data Post partly adopts diffusion equation that the data that receive are processed, and draws brain different parts blood oxygen saturation information, does further research.
The concrete job step of above-mentioned measuring system is:
(1) after whole system powers on, by each item running parameter of operator through computer user interface setting measurement system;
(2) the inner cosine and sine signal generating module of FPGA is according to the parameter of last step setting; Produce 48 way word cosine and sine signals; After digital-to-analogue conversion and filtering conditioning, be input to the analog-modulated input of corresponding LD controller, control LD produces the pumping signal of amplitude modulation(PAM);
(3) output of a last step LD is coupled to 24 point of excitation of self adaptation gauge head by the wavelength difference through wavelength division multiplexer in twos, and tested position is applied excitation, imports to corresponding detector through 32 road detection optical fibers that are distributed in the self adaptation gauge head afterwards.
(4) output of detector is connected to the corresponding input pin of FPGA measuring system, is realized the synchronous demodulation of the light intensity signal of corresponding not homology spy combination afterwards by the multichannel phase-lock detecting circuit, and sends on the computer through telecommunication circuit.
(5) part of the Data Post on the computer is tried to achieve the spatial distribution of brain different parts blood oxygen saturation with in the program of data substitution based on diffusion equation that receives, and realizes final cerebral function imaging.
Utilize the step of diffusion equation calculating blood oxygen saturation following:
The absorptance expression formula of arterial blood and venous blood is:
In the formula
Be the arterial blood absorptance;
Be the venous blood absorptance; H is a hematocrit; V
iBe erythrocyte volume; S
aO
2Be arterial oxygen saturation; S
vO
2Be Svo2, generally get
Be the red proteic absorption cross-section of Oxygenated blood;
Absorption cross-section for deoxyhemoglobin.Can be according to the absorptance of venous blood and arterial blood in the hope of organizer corresponding minimum and maximum absorptance μ when heart contraction and the diastole
MaxAnd μ
Min
Tissue is a strong scattering medium near infrared band, and therefore available diffusion equation is described light in the intravital communication process of people, and the reflective light intensity expression formula of being extrapolated by diffusion equation is:
In the formula, the reflective light intensity that the point that R (ρ) is ρ for surperficial upward distance sources records; ρ is that the distance between the point is visited in the source; μ
aBe absorptance; z
X, mFor electrode couple that adapts to the diffusion equation boundary condition for identical m, z
3, mAnd z
4, mBe a pair of electrode couple, m can infinitely produce here and under the prerequisite that guarantees precision, get three groups for calculating easy.z
3, m=-2ms-4mz
e-z
0, z
4, m=-2ms-(4m-2) z
e+ z
0S is a tissue thickness; M=0, ± 1; z
0=1/ μ
s, μ
sBe scattering coefficient; z
e=2AD, wherein A=(1+R
f)/(1-R
f) be constant, for organizer-air boundary A=0.4258; D is photon diffusion coefficient D=1/3 (μ
s'+μ
s), μ
s' be reduced scattering coefficient; z
0For the far field point, at this g=1.Generally, when adopting the double wave regular way to measure blood oxygen saturation, we introduce variable R,
N wherein
λ(ρ)=(R
Max(ρ)-R
Min(ρ))/R
Max(ρ), R
Max(ρ) be the reflective light intensity maximum, R
Min(ρ) be the reflective light intensity minima, R
Max(ρ) and R
Min(ρ) can pass through μ
MaxAnd μ
MinSubstitution diffusion equation analytic solutions are tried to achieve.Can obtain R value and S thus
aO
2Between relation curve, through multinomial this curve is carried out match and finds the best fit multinomial, obtain polynomial expression formula.Thereby obtain the R value according to the maximum of light intensity under the pulse wave that measures and minima and be brought into the counter blood oxygen saturation of releasing this sensing point place in this multinomial.This algorithm can can't harm and obtain organizing SO in real time
2Absolute magnitude, this is its most significantly advantage.Because this algorithm uses the luminous and constant incident illumination of intensity continuously, therefore still belong to the scope of continuous wave (CW) method.
Claims (3)
1. a multichannel Near-infrared Brain functional imaging parallel detection system comprises the Lights section, probe part, explorer portion, multi-channel digital phase-lock detecting circuit and computer.Wherein,
Described the Lights section comprises the multiple sets of light sources unit; Every group of unit comprises the stable state semiconductor laser of two different wave lengths and separately digital-to-analogue conversion and filter circuit and current controller; Wavelength division multiplexer and source optical fiber; The modulated-analog signal that obtains after the processing of modulation of source signal through digital-to-analogue conversion and filter circuit is as the input of current controller, and two laser instrument are sent into probe part through source optical fiber in the driving of separately current controller after the light of generation passes through wavelength division multiplexer down;
Described probe part comprises a plurality of fiber bench, and each fiber bench links to each other through connecting band, constitutes a netted path; Each source optical fiber is connected on the different fibers seat;
Described detector comprises many group detector cells; Each detector cells comprises detection optical fiber, filtering wheels, photomultiplier tube, pulse examination and integer circuit; One end of described detection optical fiber is connected on the fiber bench; The other end is connected to the filtering wheels, obtains voltage pulse signal after the processing of optical signal through photomultiplier tube and pulse examination and integer circuit of filtering wheels output; Each detection optical fiber is connected respectively on the different fibers seat;
Described multi-channel digital phase-lock detecting circuit; Comprise top layer control logic circuit, amplitude demodulation module, cosine and sine signal generator module; Under the control of top layer control logic circuit; Produce digital cosine and sine signal by the cosine and sine signal generator module, as lock phase reference signal detection and the needed modulation of source signal of the Lights section, the amplitude demodulation module is according to lock phase reference signal detection; Plurality of voltages pulse signal to detector output carries out frequency division multiplexing synchronous demodulation, and the signal of process synchronous demodulation is admitted to computer;
Described computer obtains cerebral blood oxygen saturation according to the synchronous demodulation signal of multi-channel digital phase-lock detecting circuit input, and realizes cerebral function imaging.
2. multichannel Near-infrared Brain functional imaging parallel detection according to claim 1 system is characterized in that, each is organized light source cell and forms by two groups of stable state semiconductor lasers of wavelength 690nm and 830nm.
3. multichannel Near-infrared Brain functional imaging parallel detection according to claim 1 system is characterized in that the frequency that each stable state semiconductor laser is produced has nothing in common with each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110286531A CN102327111A (en) | 2011-09-23 | 2011-09-23 | Multichannel near-infrared brain functional imaging parallel detection system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110286531A CN102327111A (en) | 2011-09-23 | 2011-09-23 | Multichannel near-infrared brain functional imaging parallel detection system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102327111A true CN102327111A (en) | 2012-01-25 |
Family
ID=45479270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110286531A Pending CN102327111A (en) | 2011-09-23 | 2011-09-23 | Multichannel near-infrared brain functional imaging parallel detection system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102327111A (en) |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579053A (en) * | 2012-03-02 | 2012-07-18 | 天津大学 | Reflective pulse blood oxygen detecting method based on diffusion theory |
| CN102599888A (en) * | 2012-03-02 | 2012-07-25 | 天津大学 | Optical topology imaging system and method on basis of digital phase locking detection technology |
| CN103117973A (en) * | 2013-03-06 | 2013-05-22 | 中国科学院自动化研究所 | Multiplex parallel demodulating system based on orthogonal detection |
| CN103263274A (en) * | 2013-05-24 | 2013-08-28 | 桂林电子科技大学 | Expression display device based on FNIRI and ERP |
| CN103610467A (en) * | 2013-11-05 | 2014-03-05 | 李鲁亚 | Parallel near-infrared photoelectric sensing device and system and method for detecting organs and tissue of animals |
| CN103728446A (en) * | 2013-12-11 | 2014-04-16 | 天津大学 | Photon counting multi-channel time-resolved fluorescence immunoassay system and counting method |
| CN104107051A (en) * | 2014-07-31 | 2014-10-22 | 中国科学院自动化研究所 | Portable multiple brain region blood oxygen detection and real-time display system |
| CN104146714A (en) * | 2014-08-21 | 2014-11-19 | 天津大学 | Organizer local oxyhemoglobin saturation variation topology imaging device and method |
| CN104375635A (en) * | 2014-08-14 | 2015-02-25 | 华中科技大学 | Quick near-infrared brain-computer interface method |
| TWI487504B (en) * | 2012-08-13 | 2015-06-11 | Univ Nat Chiao Tung | Near-infrared spectroscopy for examination of concentrations of hemoglobin |
| CN104814756A (en) * | 2015-04-29 | 2015-08-05 | 北京永新医疗设备有限公司 | Electronic system, signal processing method thereof and single photon emission computerized tomography imaging equipment |
| CN105136672A (en) * | 2015-04-23 | 2015-12-09 | 天津大学 | Area array emission light position triangle wave frequency coding imaging light measuring system |
| CN105919554A (en) * | 2016-04-15 | 2016-09-07 | 南京航空航天大学 | Ultrasonic near infrared combined detection probe |
| CN106073716A (en) * | 2016-06-28 | 2016-11-09 | 丹阳慧创医疗设备有限公司 | A kind of multicenter near-infrared spectrum cerebral function formation method of intelligence frequency-division modulation |
| CN106175792A (en) * | 2016-08-31 | 2016-12-07 | 北京利络科技有限公司 | A kind of variable frequency domain detection system for near-infrared brain scans |
| CN106236068A (en) * | 2016-08-25 | 2016-12-21 | 中国科学院苏州生物医学工程技术研究所 | A kind of cerebral blood flow measurement apparatus, system and the helmet |
| CN106691375A (en) * | 2016-11-28 | 2017-05-24 | 武汉资联虹康科技股份有限公司 | Near infrared spectral imaging system |
| CN106725520A (en) * | 2016-12-31 | 2017-05-31 | 中国科学院苏州生物医学工程技术研究所 | The signal processing method system of brain blood oxygen detection |
| CN107252305A (en) * | 2017-06-18 | 2017-10-17 | 天津大学 | The NIRS cerebral function imaging systems of phase photon counting detection pattern are locked based on full parellel |
| WO2018165992A1 (en) * | 2017-03-13 | 2018-09-20 | 博睿泰克科技（宁波）有限公司 | Apparatus and method for multi-channel functional imaging of brain |
| CN108680578A (en) * | 2018-03-14 | 2018-10-19 | 西安工业大学 | A kind of detecting system and method for multispectral frequency division multiplexing |
| CN110179472A (en) * | 2019-06-05 | 2019-08-30 | 佛山科学技术学院 | A kind of method and system of brain function detection |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6240309B1 (en) * | 1995-10-06 | 2001-05-29 | Hitachi, Ltd. | Optical measurement instrument for living body |
| US6264610B1 (en) * | 1999-05-05 | 2001-07-24 | The University Of Connecticut | Combined ultrasound and near infrared diffused light imaging system |
| CN1602808A (en) * | 2004-11-29 | 2005-04-06 | 清华大学 | Multicenter near-infrared diffuseness imaging system for cerebral function image |
| CN101816552A (en) * | 2010-05-11 | 2010-09-01 | 天津大学 | Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system |
| CN101832815A (en) * | 2010-04-30 | 2010-09-15 | 天津大学 | Multi-channel single photon counting measuring system based on digital lock phase de-multiplex |
-
2011
- 2011-09-23 CN CN201110286531A patent/CN102327111A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6240309B1 (en) * | 1995-10-06 | 2001-05-29 | Hitachi, Ltd. | Optical measurement instrument for living body |
| US6264610B1 (en) * | 1999-05-05 | 2001-07-24 | The University Of Connecticut | Combined ultrasound and near infrared diffused light imaging system |
| CN1602808A (en) * | 2004-11-29 | 2005-04-06 | 清华大学 | Multicenter near-infrared diffuseness imaging system for cerebral function image |
| CN101832815A (en) * | 2010-04-30 | 2010-09-15 | 天津大学 | Multi-channel single photon counting measuring system based on digital lock phase de-multiplex |
| CN101816552A (en) * | 2010-05-11 | 2010-09-01 | 天津大学 | Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system |
Non-Patent Citations (1)
| Title |
|---|
| 徐可欣，等: "《生物医学光子学》", 30 September 2007, article "光与生物组织体的相互作用", pages: 15 * |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599888A (en) * | 2012-03-02 | 2012-07-25 | 天津大学 | Optical topology imaging system and method on basis of digital phase locking detection technology |
| CN102579053A (en) * | 2012-03-02 | 2012-07-18 | 天津大学 | Reflective pulse blood oxygen detecting method based on diffusion theory |
| TWI487504B (en) * | 2012-08-13 | 2015-06-11 | Univ Nat Chiao Tung | Near-infrared spectroscopy for examination of concentrations of hemoglobin |
| CN103117973A (en) * | 2013-03-06 | 2013-05-22 | 中国科学院自动化研究所 | Multiplex parallel demodulating system based on orthogonal detection |
| CN103263274A (en) * | 2013-05-24 | 2013-08-28 | 桂林电子科技大学 | Expression display device based on FNIRI and ERP |
| CN103263274B (en) * | 2013-05-24 | 2014-12-17 | 桂林电子科技大学 | Expression display device based on FNIRI and ERP |
| CN103610467A (en) * | 2013-11-05 | 2014-03-05 | 李鲁亚 | Parallel near-infrared photoelectric sensing device and system and method for detecting organs and tissue of animals |
| CN103728446A (en) * | 2013-12-11 | 2014-04-16 | 天津大学 | Photon counting multi-channel time-resolved fluorescence immunoassay system and counting method |
| CN103728446B (en) * | 2013-12-11 | 2016-02-24 | 天津大学 | Photon counting-type hyperchannel time resolved fluoro-immunoassay system and method for counting |
| CN104107051A (en) * | 2014-07-31 | 2014-10-22 | 中国科学院自动化研究所 | Portable multiple brain region blood oxygen detection and real-time display system |
| CN104375635A (en) * | 2014-08-14 | 2015-02-25 | 华中科技大学 | Quick near-infrared brain-computer interface method |
| CN104375635B (en) * | 2014-08-14 | 2017-07-11 | 华中科技大学 | A kind of quick Near-infrared Brain machine interface method |
| CN104146714A (en) * | 2014-08-21 | 2014-11-19 | 天津大学 | Organizer local oxyhemoglobin saturation variation topology imaging device and method |
| CN105136672A (en) * | 2015-04-23 | 2015-12-09 | 天津大学 | Area array emission light position triangle wave frequency coding imaging light measuring system |
| CN104814756A (en) * | 2015-04-29 | 2015-08-05 | 北京永新医疗设备有限公司 | Electronic system, signal processing method thereof and single photon emission computerized tomography imaging equipment |
| CN105919554A (en) * | 2016-04-15 | 2016-09-07 | 南京航空航天大学 | Ultrasonic near infrared combined detection probe |
| CN106073716A (en) * | 2016-06-28 | 2016-11-09 | 丹阳慧创医疗设备有限公司 | A kind of multicenter near-infrared spectrum cerebral function formation method of intelligence frequency-division modulation |
| CN106073716B (en) * | 2016-06-28 | 2017-11-24 | 丹阳慧创医疗设备有限公司 | A kind of multicenter near-infrared spectrum cerebral function imaging method of intelligent frequency-division modulation |
| CN106236068A (en) * | 2016-08-25 | 2016-12-21 | 中国科学院苏州生物医学工程技术研究所 | A kind of cerebral blood flow measurement apparatus, system and the helmet |
| CN106175792A (en) * | 2016-08-31 | 2016-12-07 | 北京利络科技有限公司 | A kind of variable frequency domain detection system for near-infrared brain scans |
| CN106691375A (en) * | 2016-11-28 | 2017-05-24 | 武汉资联虹康科技股份有限公司 | Near infrared spectral imaging system |
| CN106725520A (en) * | 2016-12-31 | 2017-05-31 | 中国科学院苏州生物医学工程技术研究所 | The signal processing method system of brain blood oxygen detection |
| WO2018165992A1 (en) * | 2017-03-13 | 2018-09-20 | 博睿泰克科技（宁波）有限公司 | Apparatus and method for multi-channel functional imaging of brain |
| CN106805970B (en) * | 2017-03-13 | 2020-05-05 | 博睿泰克科技（宁波）有限公司 | Multi-channel brain function imaging device and method |
| CN107252305A (en) * | 2017-06-18 | 2017-10-17 | 天津大学 | The NIRS cerebral function imaging systems of phase photon counting detection pattern are locked based on full parellel |
| CN108680578A (en) * | 2018-03-14 | 2018-10-19 | 西安工业大学 | A kind of detecting system and method for multispectral frequency division multiplexing |
| CN110179472A (en) * | 2019-06-05 | 2019-08-30 | 佛山科学技术学院 | A kind of method and system of brain function detection |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102327111A (en) | Multichannel near-infrared brain functional imaging parallel detection system | |
| Koizumi et al. | Higher-order brain function analysis by trans-cranial dynamic near-infrared spectroscopy imaging | |
| Scholkmann et al. | A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology | |
| CN107252305B (en) | NIRS brain function imaging system based on full parallel phase-locked photon counting detection mode | |
| Franceschini et al. | On-line optical imaging of the human brain with 160-ms temporal resolution | |
| Fantini et al. | Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry | |
| US10595741B2 (en) | Method and system for brain activity detection | |
| Ferrari et al. | A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application | |
| Atsumori et al. | Development of wearable optical topography system for mapping the prefrontal cortex activation | |
| Durduran | Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods | |
| Gratton et al. | The event-related optical signal: a new tool for studying brain function | |
| Applegate et al. | Recent advances in high speed diffuse optical imaging in biomedicine | |
| CN103735274B (en) | A kind of local brain tissue blood oxygen blood holds absolute amount detection device and detection method | |
| CN104146714B (en) | Organizer local oxyhemoglobin saturation variation topology imaging device and method | |
| CN102641126A (en) | Sensor, apparatus and method for non-invasively monitoring blood characteristics of subject | |
| Blasi et al. | Investigation of depth dependent changes in cerebral haemodynamics during face perception in infants | |
| Yu et al. | Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics | |
| Chiarelli et al. | Fiberless, multi-channel fNIRS-EEG system based on silicon photomultipliers: towards sensitive and ecological mapping of brain activity and neurovascular coupling | |
| Yang et al. | Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics | |
| CN102599888A (en) | Optical topology imaging system and method on basis of digital phase locking detection technology | |
| CN103868870A (en) | Blood composition analysis system and method combining absorption spectrum with reflection spectrum | |
| CN106691375A (en) | Near infrared spectral imaging system | |
| Zhou et al. | Review of recent advances in frequency-domain near-infrared spectroscopy technologies | |
| Lacerenza et al. | Monitoring the motor cortex hemodynamic response function in freely moving walking subjects: a time-domain fNIRS pilot study | |
| Mainard et al. | Intraoperative optical monitoring of spinal cord hemodynamics using multiwavelength imaging system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120125 |