CN1602808A - Multicenter near-infrared diffuseness imaging system for cerebral function image - Google Patents
Multicenter near-infrared diffuseness imaging system for cerebral function image Download PDFInfo
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- CN1602808A CN1602808A CN 200410096077 CN200410096077A CN1602808A CN 1602808 A CN1602808 A CN 1602808A CN 200410096077 CN200410096077 CN 200410096077 CN 200410096077 A CN200410096077 A CN 200410096077A CN 1602808 A CN1602808 A CN 1602808A
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Abstract
The invention relates to multi-access near infrared light diffusion imaging system of brain functional research, which belongs to medical equipment technological field, comprising of near infrared light laser source, multi-access optical fiber switcher, reflected sensing head with multi-light source and multi-detector, electro optical signal collecting and magnifying circuit system, computer with data collection card and program or controlling signal collection and imaging. The sensing head is reflected sensing head with multi- light source and multi-detector, with a rectangular slice made of soft material as substrate; the light source and detector arrange according to the way of rectangular array, each detector light source is embedded in the central point of rectangular area formed by four light sources or switcher adjacent. Besides, the invention uses the way of contrast imaging, eliminating the effect caused by mismatching between the access, and it doesn't bring hurt, pocketable and stable, also, it can realize real time dynamic imaging which is easier to understand, suitable for clinical application.
Description
Technical field
The invention belongs to the armarium technical field, particularly be used for the imaging system design of brain function research.
Background technology
Present capital equipment PET (positron emission tomography imaging) and fMRI (brain function type NMR (Nuclear Magnetic Resonance)-imaging) about brain function research.These two kinds of equipment all diminish, and should not use (such as to baby, anemia of pregnant woman or under the situations such as the brain acupuncture point applies acupuncture) in some cases.PET imaging and MRI imaging cost and cost are all very high, and use inconvenience.By contrast, though near infrared light imaging equipment imaging resolution is not so good as PET and fMRI, cost is low, and relatively portable, application that can be more convenient and various occasion.
Near-infrared spectrum technique mainly is to have utilized tissue near infrared light to be had the characteristic of absorption and scattering.And blood is the absorbing material of topmost near infrared light in the tissue, so the near infrared light detection technique is highstrung for the variation of blood and blood oxygen.About the near infrared light imaging system, did much relevant work before the present application people, and obtained preliminary achievement.Comprise a kind of digital near-infrared medical imaging and foreign body navigation system and digital near-infrared diffusion computed tomography (SPECT) system.
Digital near-infrared medical imaging system (number of patent application: 03145957.9), it adopts high frequency near infrared light laser as detection light source, by receiving the photon that sees through human body, physiological tissues such as the soft tissue of human body such as mammary gland are carried out imaging, has stable performance, good reliability, characteristics such as resolution height.But for cerebral function imaging, near infrared light almost can't penetrate whole head, and the scanning projection imaging mode that this system adopted also is not suitable for cerebral function imaging.
A kind of digital near-infrared diffusion computed tomography (SPECT) system, what it adopted is single wavelength, the measuring method of continuous wave, its structure is as shown in Figure 1.The composition of system comprises light source, fibre-switch, probe, the computer of photoelectric signal collection amplification system and band NI-DAQ data collecting card.Because it all is circular that hypothesis will be carried out the cross section of the target of fault imaging, the probe that is adopted in the system also is annular structure.Light source and detector are distributed on the annular probe uniformly." zero " represents light source among the figure, i.e. optical fiber emitting head, and " ● " represents detector, i.e. silicon photoelectric diode.The probe that system adopted among Fig. 1 is the structure of 8 light sources and 8 receptors, in the scanning imagery process, lights each road light source successively by fibre-switch, and reads all 8 light intensity datas that receptor is measured simultaneously.The single pass process obtains the individual data in 64 (8 * 8) altogether like this, reads in computer and can reconstruct the faultage image that the optical parametric of measured target on cross section distributes by the gradient algorithm for reconstructing of finite element subdivision and the weighting of a kind of locus afterwards.But for brain function research, the structure of this probe exists some defectives that are difficult to overcome.Such as, since the human brain skull be difficult to the influence of penetrance and hair to the propagation of light, in certain light source luminescent, usually just around it two adjacent detectors can receive weak one, and the detector of other positions be we can say except background noise and be can't accept any optical signal basically.The data that obtain like this can reduce the result of the image of fault imaging greatly.In addition, this system to the probe designing requirement than higher, in order to improve the accuracy of measurement, usually require all vertical surface of being close to testee of light source and detector, but because the scrambling of human brain shape size, designing one can the very wide probe of the suitability be very difficult in clinical experiment.Therefore this system is not suitable for clinical brain function research experiment.Usually the occasion of its use is soft-tissue imaging or toy experiment.
Summary of the invention
The objective of the invention is to for overcoming the weak point of prior art, design a kind of multicenter near-infrared diffusion imaging system that is suitable for the brain function cerebral function imaging, mainly be that the structure of probe is improved, make it to be used to detect one in the specific region blood oxygen and the situation of change (such as forehead) of blood flow, can carry out two-dimensional imaging to the corticocerebral activity of respective regions, be applicable to clinical brain function research.
A kind of multicenter near-infrared diffusion imaging system that is used for brain function research that the present invention proposes, comprise near-infrared light source, fibre-switch, probe, the responsible signals collecting control of the computer of photoelectric signal collection amplification system and band data collecting card and operation on computers and the program of imaging; This light source links to each other with the input of fibre-switch by tail optical fiber, this probe links to each other with the photoelectric signal collection amplification system with the outfan of fibre-switch respectively, this computer links to each other with another input of fibre-switch, also links to each other with this photoelectric signal collection amplification system simultaneously; It is characterized in that, described probe is the reflective probe of multiple light courcess multi-detector, be to be substrate with the rectangular tab that a soft material is made, m * m light source and n * n detector are evenly distributed on this thin slice, wherein, m and n be 〉=1 positive integer, and be not 1 simultaneously, this light source and detector according to close one to one tie up on this thin slice evenly distributed, mode according to rectangular array between light source and the light source is arranged, and each detector or light source are embedded in the mid point of the rectangular area of per 4 adjacent light sources or detector composition.
Characteristics of the present invention mainly are based on existing digital medical near-infrared imaging system, sonde configuration is improved, utilize the probe of equally distributed one group of light source-combinations of detectors, the near infrared light signal after the human brain tissue refraction that distance less (being generally 1-4 centimetre) between light source and the corresponding detector, detector receive light emitted comes the blood of certain depth in regional between detection light source and the detector and the situation of change of blood oxygen.According to the most probable path theory that near infrared light is propagated in turbid material, the distance between detector and the light source has determined the degree of depth in the path that the received optical signal of detector is passed by in human brain.This mode has real-time, but characteristics such as continuous monitoring.But can only be confined in certain less zone.In the present invention, the combination of this " light source-detector " is extended to many groups by one group, in two-dimensional space, arrange according to certain rules, make it to be used to detect the big regional interior blood oxygen and the situation of change (such as forehead) of blood flow, and can carry out dynamic two-dimensional imaging the corticocerebral activity of respective regions.
Description of drawings
Fig. 1 is the structured flowchart of existing a kind of digital near-infrared diffusion computed tomography (SPECT) system.
Fig. 2 is a system architecture diagram of the present invention.
Fig. 3 is the structural principle sketch map of the probe among the present invention.
Fig. 4 is a scanning imagery program flow diagram of the present invention.
Fig. 5 is the other forms of sketch map of the probe among the present invention.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is further detailed.
Multicenter near-infrared being diffused into that is used for cerebral function imaging of the present invention looks like system structure as shown in Figure 2.Comprise light source (present embodiment adopts the 808nm laser instrument), fibre-switch, probe, the computer of photoelectric signal collection amplification system and band data collecting card (present embodiment adopts the NI-DAQ capture card); This light source links to each other with the input of fibre-switch by tail optical fiber, probe links to each other with the photoelectric signal collection amplification system with the outfan of fibre-switch respectively, computer links to each other with another input of fibre-switch, also links to each other with the photoelectric signal collection amplification system simultaneously.As can be seen, basic composition of the present invention is identical with the formation of digital near-infrared diffusion computed tomography (SPECT) system shown in Figure 1, and substantial difference is that the structure of probe is improved.The probe that the present invention adopts is the reflective probe of multiple light courcess multi-detector, be to be substrate with the rectangular tab that a soft material is made, m * m light source and n * n detector are evenly distributed on the thin slice wherein, m and n be 〉=1 positive integer, and be not 1 simultaneously, light source and detector according to close one to one tie up in the probe substrate evenly distributed.Mode according to rectangular array between light source and the light source is arranged, and each detector or light source are embedded in the mid point of the rectangular area of per 4 adjacent light sources or detector composition." zero " representative and light source (optical fiber head of present embodiment) among the figure for linking to each other with laser instrument; " ■ " represents detector (being silicon photoelectric diode in the present embodiment).In clinical brain function research, this probe can be close on the human brain scalp.Guarantee that light source contacts scalp fully with detector, reduce the interference of boundary effect and surround lighting.
A kind of sonde configuration embodiment of the present invention promptly adopts 2 * 2 light sources to add the structure of 3 * 3 detectors as shown in Figure 3, and the circle among Fig. 3 represents that light source is an optical fiber head, the optical channel on corresponding its fibre-switch of numeral of the inside number.Square is represented detector, the channel number of its pairing acquisition system of digitized representation wherein.Range distribution between the adjacent probe is 4.5 centimetres (horizontal directions) and 2.5 centimetres (vertical direction), and the rectangular area size of composition is 9 * 5 centimetres.Distance between light source and the detector is 2.5 centimetres.Theoretic penetration depth can reach 2 centimetres.The blood oxygen active situation that in the brain function test, can reflect people's cortex basically.The detector that each light source and it are closed on is formed a light source-detector set, and the signal attenuation between them has reflected that tissue is to the absorbing state of near infrared light under the regional certain depth between them.For example, light source 1 and detector 1 pairing, what they detected is the situation in zone (1,1).Light source 1 matches with detector 2,4,5 again simultaneously, difference monitored area (2,1), the situation of (1,2) and (2,2).
The scanning imagery program circuit that the present invention adopts above-mentioned sonde configuration as shown in Figure 4, may further comprise the steps: between each scanning imagery begins, need carry out some initialization to system, as the artificial amplification that each passage correspondence is set of mode by programming in advance.Control fibre-switch then and make light source output to optical fiber No. 1,, after light source switches, wait for 0.5 second, read corresponding 4 optical signal datas that detector is measured then in order to obtain more stable measurement result.For No. 1 optical fiber, corresponding probe access is 1,2,4,5.Finish after the switching of 4 light sources.16 groups of data that obtain are put in order according to the spatial distribution situation.After the data of putting in order are carried out two-dimensional interpolation, can be used for drawing gray-scale map or pcolor picture, can reflect the light absorption situation of measured target very intuitively.
For the error that the output intensity of eliminating each road optical fiber and the difference between the probe access are brought, what the present invention adopted in the application of reality is a kind of contrast imaging mode.Also adopted in the digital near-infrared diffusion computed tomography (SPECT) system that this mode is mentioned in front.Be exactly for same measured target in brief, two different constantly adopt two groups of data compare one by one, for example be divided by respectively, the imaging results reflection after the contrast be that the optical parametric of measured target is these two the different situations of change that constantly taken place.This imaging mode is applied on the clinical brain function research, usually be in one group of data of measurement under certain normal state as the reference data with the testee, subsequently the testee being carried out certain stimulates the data that record afterwards all to compare with reference data, and what the result reflected is the optical parametric situation of change of certain part of testee.For head, its reflection mainly be the situation of change of corticocerebral blood volume and blood flow, thereby further reflect the function of brain specific region.
The structure of the present invention's probe is not limited to the described this structure of Fig. 3, experiment situation according to reality can be expanded the number of light source and detector, as 3 * 3 light sources of embedding in 4 * 4 detectors, perhaps 4 * 4 light sources add 5 * 5 detectors, can certainly be that a light source adds four easy structure that detector is such.But because the distance of detector and light source has determined investigation depth, therefore distance can not be too small can not be excessive, the too little detection of distance is less than the information of deep tissues, distance is too big, and optical signal is absorbed too much, the signal that detector receives too a little less than.As a rule distance should be between 1 centimetre to 4 centimetres, and 2 to 3 centimetres is optimum selection.Therefore for the probe that is used for cerebral function imaging, the increase that light source and detector number can not be unlimited can not surpass 5 * 5 detectors or 5 * 5 structures that light source is so usually.Also can replace light source and detector in the described this sonde configuration of this external Fig. 3, change detector into and be embedded in structure among the light source, as shown in Figure 5.The position of original light source is changed into detector, and position of detector changes light source into.2 * 2 detectors like this add the structure of 3 * 3 light sources, reduced the number of detector, thereby reduced the number of active lanes of photoelectric signal collection system, further reduce the cost of hardware and improved the stability and the ease for operation of hardware, but switch owing to need to carry out 9 optical fiber in the single pass process, thereby increased the time of scanning, reduced the speed of imaging.
Claims (2)
1, plants the multicenter near-infrared diffusion imaging system that is used for brain function research, comprise near-infrared light source, fibre-switch, probe, the responsible signals collecting control of the computer of photoelectric signal collection amplification system and band data collecting card and operation on computers and the program of imaging; This light source links to each other with the input of fibre-switch by tail optical fiber, this probe links to each other with the photoelectric signal collection amplification system with the outfan of fibre-switch respectively, this computer links to each other with another input of fibre-switch, also links to each other with this photoelectric signal collection amplification system simultaneously; It is characterized in that, described probe is the reflective probe of multiple light courcess multi-detector, be to be substrate with the rectangular tab that a soft material is made, m * m light source and n * n detector are evenly distributed on this thin slice, wherein, m and n be 〉=1 positive integer, and be not 1 simultaneously, this light source and detector according to close one to one tie up on this thin slice evenly distributed, mode according to rectangular array between light source and the light source is arranged, and each detector or light source are embedded in the mid point of the rectangular area of per 4 adjacent light sources or detector composition.
2, the system as claimed in claim 1 is characterized in that, described m and n are 1≤m, n≤5; The distance of described detector and light source is between 1 centimetre to 4 centimetres.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409806C (en) * | 2005-08-09 | 2008-08-13 | 中国科学院自动化研究所 | Right-hexagon shape and high resolution ratio near infrared spectrum cerebral function imaging helmet |
| CN102327111A (en) * | 2011-09-23 | 2012-01-25 | 天津析像光电科技有限公司 | Multichannel near-infrared brain functional imaging parallel detection system |
| TWI504380B (en) * | 2012-11-08 | 2015-10-21 | Univ Nat Chiao Tung | Portable 2-dimension oximeter image device |
| CN105919554A (en) * | 2016-04-15 | 2016-09-07 | 南京航空航天大学 | Ultrasonic near infrared combined detection probe |
| CN107019516A (en) * | 2017-03-31 | 2017-08-08 | 北京心灵方舟科技发展有限公司 | Suppressing method, device and the detection device of near-infrared noise |
| WO2018165992A1 (en) * | 2017-03-13 | 2018-09-20 | 博睿泰克科技（宁波）有限公司 | Apparatus and method for multi-channel functional imaging of brain |
-
2004
- 2004-11-29 CN CN 200410096077 patent/CN1602808A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409806C (en) * | 2005-08-09 | 2008-08-13 | 中国科学院自动化研究所 | Right-hexagon shape and high resolution ratio near infrared spectrum cerebral function imaging helmet |
| CN102327111A (en) * | 2011-09-23 | 2012-01-25 | 天津析像光电科技有限公司 | Multichannel near-infrared brain functional imaging parallel detection system |
| TWI504380B (en) * | 2012-11-08 | 2015-10-21 | Univ Nat Chiao Tung | Portable 2-dimension oximeter image device |
| CN105919554A (en) * | 2016-04-15 | 2016-09-07 | 南京航空航天大学 | Ultrasonic near infrared combined detection probe |
| WO2018165992A1 (en) * | 2017-03-13 | 2018-09-20 | 博睿泰克科技（宁波）有限公司 | Apparatus and method for multi-channel functional imaging of brain |
| CN106805970B (en) * | 2017-03-13 | 2020-05-05 | 博睿泰克科技（宁波）有限公司 | Multi-channel brain function imaging device and method |
| CN107019516A (en) * | 2017-03-31 | 2017-08-08 | 北京心灵方舟科技发展有限公司 | Suppressing method, device and the detection device of near-infrared noise |
| CN107019516B (en) * | 2017-03-31 | 2020-11-10 | 北京心灵方舟科技发展有限公司 | Method and device for suppressing near-infrared noise and detection equipment |
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