CN110367942B - Photoacoustic imaging system and method - Google Patents
Photoacoustic imaging system and method Download PDFInfo
- Publication number
- CN110367942B CN110367942B CN201910784911.0A CN201910784911A CN110367942B CN 110367942 B CN110367942 B CN 110367942B CN 201910784911 A CN201910784911 A CN 201910784911A CN 110367942 B CN110367942 B CN 110367942B
- Authority
- CN
- China
- Prior art keywords
- photoacoustic
- ultrasonic transducer
- imaged
- dimensional
- laser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4488—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5269—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving detection or reduction of artifacts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/04—Analysing solids
- G01N29/06—Visualisation of the interior, e.g. acoustic microscopy
- G01N29/0654—Imaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Acoustics & Sound (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Gynecology & Obstetrics (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
The application discloses photoacoustic imaging system and method can excite an object to be imaged to generate photoacoustic signals through a laser, acquire the photoacoustic signals transmitted to a three-dimensional space through a three-dimensional phased array ultrasonic transducer, realize three-dimensional imaging, improve the acquisition rate of the photoacoustic signals and have better imaging quality. The invention carries out low-noise amplification, filtering and high-speed parallel analog-to-digital conversion on the captured multi-channel photoacoustic signal, reconstructs, processes and displays the image, and can recover the three-dimensional space distribution of the absorber in the object to be imaged; multispectral imaging is carried out by scanning laser wavelength, so that noninvasive representation of chemical components can be realized; by analyzing the frequency spectrum of the received ultrasonic signal, noninvasive characterization of physical properties can be realized; the processing speed of multi-channel signals and images can be improved by GPU acceleration; the multi-row photoacoustic imaging can be realized, the three-dimensional volume image can be obtained at high speed, and the problem that the traditional photoacoustic imaging can only carry out two-dimensional tomography is solved.
Description
Technical Field
The invention relates to the technical field of photoacoustic imaging, in particular to a photoacoustic imaging system and method.
Background
Compared with the traditional ultrasonic detection technology, the ultrasonic phase control technology has many advantages. The ultrasonic phase control technology adopts an electronic method to control deflection, focusing and scanning of the sound beam, can carry out rapid scanning under the condition of not moving or little moving of the transducer, has good sound beam accessibility, can detect objects to be detected with complex geometric shapes and blind areas thereof, and can improve the performances such as detection resolution, signal-to-noise ratio and the like by optimizing and controlling the focal size, the focal area depth and the sound beam direction, so that the detected image is clearer, and the detection speed is quicker.
Due to the advantages, the photoacoustic imaging system and method based on the ultrasonic phase control technology are widely applied to the fields of medical ultrasonic imaging, industrial nondestructive testing and the like. The phased array ultrasonic transducer is a core component for realizing an ultrasonic phased technology, and when the existing phased array ultrasonic transducer is used for photoacoustic imaging, the acquisition rate of photoacoustic signals is low, the imaging sensitivity is low, and the imaging quality is poor.
Disclosure of Invention
In view of this, the technical solution of the present invention provides a photoacoustic imaging system and method, which can improve the collection rate of photoacoustic signals, improve the sensitivity, and have better imaging quality.
In order to achieve the above purpose, the invention provides the following technical scheme:
a photoacoustic imaging system, the photoacoustic imaging system comprising:
the laser is used for emitting laser pulses to irradiate the object to be imaged, and the object to be imaged is excited to generate a photoacoustic signal which propagates to a three-dimensional space through a thermoelastic effect;
a three-dimensional phased array ultrasonic transducer for acquiring the photoacoustic signal propagating into a three-dimensional space; the three-dimensional phased array ultrasonic transducer is provided with a columnar substrate, an ultrasonic transducer array is fixed on the columnar substrate and comprises a plurality of rows of ultrasonic transducer array elements surrounding the central axis of the columnar substrate; the axis is a connecting line of the midpoint of the top surface and the midpoint of the bottom surface of the columnar substrate;
a multi-channel data acquisition circuit for performing signal processing on the photoacoustic signals acquired by the three-dimensional phased array ultrasonic transducer;
a computer for forming a three-dimensional photoacoustic image of the object to be imaged based on the photoacoustic signals after signal processing.
Preferably, in the photoacoustic imaging system, the laser pulse generated by the laser irradiates the object to be imaged through a fiber illumination system;
wherein the fiber optic illumination system comprises: the optical fiber coupler and the multi-path optical fiber bundle; one end of the optical fiber bundle is coupled to a laser output port of the laser through the optical fiber coupler, the other ends of the multiple optical fiber bundles are distributed on the same circumference, and the circumference surrounds the object to be imaged to provide uniform illumination for the object to be imaged.
Preferably, in the photoacoustic imaging system, the laser pulse generated by the laser irradiates the object to be imaged through a free optical path illumination system;
the free light path illumination system includes: the laser device comprises a diffuser, a conical lens and a condenser, wherein laser pulses generated by the laser device sequentially pass through the diffuser, the conical lens and the condenser to irradiate the object to be imaged.
Preferably, in the photoacoustic imaging system, the three-dimensional phased array ultrasonic transducer includes a plurality of ultrasonic transducer array elements;
the multichannel data acquisition circuit includes: the system comprises a multi-channel amplifier, a multi-channel filter and a multi-channel analog-to-digital converter; each ultrasonic transducer array element corresponds to one channel independently, and the ultrasonic transducer array elements acquire the photoacoustic signals, amplify, filter and perform analog-to-digital conversion on the photoacoustic signals through the corresponding channels in sequence and then send the photoacoustic signals to the computer.
Preferably, in the photoacoustic imaging system, a time division multiplexer is provided between the multichannel data acquisition circuit and the three-dimensional phased array ultrasonic transducer, and the time division multiplexer is used for time-sharing acquisition of multichannel signals.
Preferably, in the photoacoustic imaging system, the columnar substrate has a through hole penetrating through the top surface and the bottom surface thereof, and the ultrasonic transducer array elements are fixed on the inner wall of the through hole;
or the ultrasonic transducer array elements are fixed on the outer side surface of the columnar substrate.
Preferably, in the photoacoustic imaging system described above, further comprising: and the mechanical scanning device is used for driving the object to be imaged or the three-dimensional phased array ultrasonic transducer to translate along the axis or rotate around the axis.
Preferably, in the photoacoustic imaging system described above, the columnar substrate comprises a plurality of detachable sub-columnar substrates;
at least one row of ultrasonic transducer array elements are arranged on the sub-columnar substrate;
or the sub-columnar substrate is provided with a row of the ultrasonic transducer array elements, and the number and the distribution of the ultrasonic transducer array elements on the sub-columnar substrate are the same.
The present invention also provides a photoacoustic imaging method, including:
irradiating an object to be imaged by laser pulses emitted by a laser, and exciting the object to be imaged to generate photoacoustic signals which are transmitted to a three-dimensional space by a thermoelastic effect;
acquiring the photoacoustic signal propagating to a three-dimensional space through a three-dimensional phased array ultrasonic transducer;
performing signal processing on the photoacoustic signal acquired by the three-dimensional phased array ultrasonic transducer through a multi-channel data acquisition circuit;
and forming a three-dimensional photoacoustic image of the object to be imaged based on the photoacoustic signal after the signal processing by a computer.
Preferably, in the photoacoustic imaging method described above, further comprising:
multispectral imaging is carried out by scanning the wavelength of laser within the range of ultraviolet, visible light and infrared wavelength, and noninvasive representation of chemical components of the object to be imaged is carried out based on the spectral image;
or performing spectrum analysis on ultrasonic signals received by a plurality of rows of ultrasonic transducer array elements in the three-dimensional phased array ultrasonic transducer in a Fourier domain, and performing non-invasive characterization on the physical properties of the object to be imaged based on the result of the spectrum analysis;
or, the processing speed of the collected multi-path photoacoustic signals and images is improved by a GPU acceleration method.
As can be seen from the above description, in the photoacoustic imaging system and method provided by the technical solution of the present invention, an object to be imaged can be excited by a laser to generate a photoacoustic signal, and the photoacoustic signal is acquired by a three-dimensional phased array ultrasonic transducer, where the three-dimensional phased array ultrasonic transducer has a cylindrical substrate, an ultrasonic transducer array is fixed on the cylindrical substrate, and the ultrasonic transducer array includes a plurality of rows of ultrasonic transducer elements surrounding a central axis of the cylindrical substrate, so that the three-dimensional phased array ultrasonic transducer can acquire the photoacoustic signal propagating to a three-dimensional space, thereby implementing three-dimensional imaging, improving the acquisition rate of the photoacoustic signal, improving sensitivity, and having better imaging quality. The invention can perform low-noise amplification, filtering and high-speed parallel analog-to-digital conversion on the captured multichannel photoacoustic signals through the multichannel data acquisition circuit, and then reconstruct, process and display the image through the computer, thereby recovering the three-dimensional space distribution of the absorber in the object to be imaged; multispectral imaging is carried out by scanning laser wavelength, so that noninvasive representation of chemical components can be realized; by analyzing the frequency spectrum of the received ultrasonic signal, noninvasive characterization of physical properties can be realized; the processing speed of multi-channel signals and images can be improved by GPU acceleration; the multi-row photoacoustic imaging can be realized, the three-dimensional volume image can be obtained at high speed, and the problem that the traditional photoacoustic imaging can only carry out two-dimensional tomography is solved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a diagram illustrating the results of a photoacoustic imaging system provided by an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a three-dimensional phased array ultrasonic transducer in the photoacoustic imaging system shown in FIG. 1;
FIG. 3 is a schematic structural diagram of a conventional planar array multi-row photoacoustic transducer;
FIG. 4 is a schematic diagram of another illumination system for laser irradiation of an object to be imaged according to an embodiment of the present invention;
fig. 5 is a sound field distribution diagram of a single ultrasonic transducer array element in a 7.5MHz three-dimensional phased array ultrasonic transducer according to an embodiment of the present invention;
fig. 6 is a sound field distribution diagram of a 7.5MHz three-dimensional phased array ultrasonic transducer in a set plane according to an embodiment of the present invention;
FIG. 7 is a diagram of a simulation model of an object to be imaged;
FIG. 8 is a graph of the spatial distribution of the photoacoustic field generated around a three-dimensional sphere at a time of 1.0 microsecond;
FIG. 9 is a diagram showing a photoacoustic signal distribution acquired by a three-dimensional phased array ultrasonic transducer;
fig. 10 is a three-dimensional bead image reconstructed using a back projection algorithm.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
In the fields of medical ultrasonic imaging and industrial nondestructive testing, there are three main types of phased array ultrasonic transducers that are used more, namely, linear array transducers, matrix transducers (area array transducers), and loop array transducers. A plurality of array elements in the linear array transducer are linearly arranged, and a sound field is distributed in one plane, so that an image in a two-dimensional plane can be obtained. A plurality of array elements in the matrix transducer are arranged in a rectangular area, and a sound field is distributed in a three-dimensional rectangular space, so that an object in the three-dimensional space can be imaged. Array elements in the annular array transducer are annular and are arranged according to concentric circular rings, and a sound field is also distributed in a three-dimensional space, so that an object in the three-dimensional space can be imaged. The three phased array ultrasonic transducers are simple in shape, low in design and processing complexity and controllable in cost, and can meet the requirements of most medical ultrasonic imaging and industrial nondestructive testing.
Based on energy conversion from light to sound, the emerging biomedical photoacoustic imaging technology is a noninvasive, high-resolution, high-contrast biomedical imaging modality that has been rapidly developed in recent years. The photoacoustic imaging has the advantages of high contrast of optical imaging and large penetration depth of ultrasonic imaging, microscopic imaging can be performed on a single organelle, macroscopic imaging can be performed on the whole small animal, and information of different levels of biological tissue structures, functions, metabolism, molecules, heredity and the like can be provided. At present, most of transducers adopted in photoacoustic imaging equipment directly use linear array transducers, matrix transducers and circular array transducers in ultrasonic imaging, but the principles of photoacoustic imaging and ultrasonic imaging are different, and the transducers directly use a signal receiving scheme which is not optimal. Ultrasonic imaging is to wait to form images the object transmission ultrasonic wave, based on pulse echo, the ultrasonic wave that is transmitted by the transducer is organized the back and is returned and realize forming images by organizing, and linear array or ring array transducer can satisfy most demands. Photoacoustic imaging is based on the light and heat effect, shines through laser pulse and treats the formation of image object, treats the formation of image object because the photoacoustic signal that laser excitation produced can propagate to three-dimensional space, and the receiving strategy based on linear array or ring array transducer can greatly lose useful signal, reduces image quality and imaging sensitivity. The ultrasonic phased array transducer suitable for photoacoustic signal three-dimensional space acquisition is designed, photoacoustic signals in the space are captured to the maximum extent, and the ultrasonic phased array transducer has great significance for improving imaging quality. Wherein, the photoacoustic signal is an ultrasonic wave. When the laser excites the object to be imaged, the ultrasonic wave generated by the object to be imaged is a photoacoustic signal.
Photoacoustic imaging, when used for medical ultrasound imaging, can be used for imaging living beings, the main modalities including: x-ray Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), single photon emission tomography (SPECT), ultrasound, and optical imaging, among others. Photoacoustic imaging is a new imaging modality, has been developed rapidly in recent years, has been applied to various research fields such as molecular imaging, cardiovascular disease research, drug metabolism, early diagnosis of tumors, gene expression, stem cells and immunity, neurobiology of the brain, and the like, provides more reliable and comprehensive experimental evidence for scientific research, and has wide application prospects.
Photoacoustic systems based on one-dimensional linear array transducers typically only allow two-dimensional tomographic imaging of biological tissue. In practical applications, there are many problems in two-dimensional tomography, such as the inability to obtain images of planes perpendicular to the surface of the transducer, difficulty in performing registration imaging on certain targets (e.g., curved blood vessels, biopsy needle, etc.), difficulty in quantitatively evaluating certain volume quantities (e.g., tumor three-dimensional boundaries, cardiac perfusion imaging), etc. To realize three-dimensional volume imaging by using a one-dimensional linear array transducer, a mechanical scanning transducer is needed, which can greatly reduce the imaging speed and cannot track certain dynamic change processes such as heartbeat, blood flow, intervention, perfusion imaging and the like in real time.
Compared with a linear array transducer, the planar array transducer has one more dimension, can capture photoacoustic signals from a three-dimensional space at one time, is particularly suitable for space volume imaging, and is the development direction of next-generation photoacoustic imaging. However, the increase of the dimension and the number of the transducer elements greatly increases the requirements on the multi-channel signal acquisition and real-time processing capability, which makes the whole photoacoustic system difficult to realize. Currently, the international photoacoustic imaging system based on the area array transducer only comprises a Nexus 128+ small animal photoacoustic imager, the Nexus 128+ system is a photoacoustic imaging platform based on a hemispherical transducer, three-dimensional volume imaging in the true sense can be realized, the arrangement of the transducers in the Nexus 128+ system is sparse, the number of 128 array elements cannot cover the whole imaging space, mechanical scanning is needed in the experimental process to increase the number of sampling points, and the imaging time resolution and the imaging space resolution are severely limited.
In order to solve the above problems, the technical solution of the embodiment of the present invention provides a photoacoustic imaging system, as shown in fig. 1 and fig. 2, fig. 1 is a schematic diagram of a result of the photoacoustic imaging system provided by the embodiment of the present invention, fig. 2 is a schematic diagram of a structure of a three-dimensional phased array ultrasonic transducer in the photoacoustic imaging system shown in fig. 1, a left diagram in fig. 2 is an overall view of the three-dimensional phased array ultrasonic transducer, and a right diagram is a partial schematic diagram of the three-dimensional phased array ultrasonic transducer.
The photoacoustic imaging system includes: the laser device 1 is used for emitting laser pulses to irradiate the object 4 to be imaged, and the object 4 to be imaged is excited to generate a photoacoustic signal which propagates to a three-dimensional space through a thermoelastic effect; a three-dimensional phased array ultrasonic transducer 6, the three-dimensional phased array ultrasonic transducer 6 being used for acquiring the photoacoustic signal propagating to a three-dimensional space; the three-dimensional phased array ultrasonic transducer 6 is provided with a columnar substrate 21, an ultrasonic transducer array is fixed on the columnar substrate 21 and comprises a plurality of rows of ultrasonic transducer elements 20 surrounding the central axis of the columnar substrate 21; the axis is a connecting line of the midpoint of the top surface and the midpoint of the bottom surface of the columnar substrate 21; a multi-channel data acquisition circuit 10, wherein the multi-channel data acquisition circuit 10 is used for performing signal processing on the photoacoustic signal acquired by the three-dimensional phased array ultrasonic transducer; a computer 14, the computer 14 is used for forming a three-dimensional photoacoustic image 15 of the object to be imaged based on the photoacoustic signals after signal processing.
The laser 1 may be a high-energy pulse laser, and may emit nanosecond laser light. In the mode shown in fig. 1, the laser pulse generated by the laser 1 irradiates the object 4 to be imaged through a fiber optic illumination system; wherein the fiber optic illumination system comprises: a fiber coupler 2 and a multi-path fiber bundle 3; one end of the optical fiber bundle 3 is coupled to a laser output port of the laser 1 through the optical fiber coupler 2, the other ends of the optical fiber bundles 3 are distributed on the same circumference, and the circumference surrounds the object 4 to be imaged so as to provide uniform illumination for the object 4 to be imaged. That is, the optical fiber bundle 3 is arranged around the object 4 to be imaged, and one end of the optical fiber bundle outputting the laser pulse uniformly surrounds the object 4 to be imaged, so as to provide uniform illumination for the object 4 to be imaged. Wherein the laser pulses generated by the laser 1 can be coupled to the fiber coupler 2 via a reflecting device 19. The fiber coupler 2 may comprise a telescopic system, i.e. the fiber coupler 2 may be implemented by a telescopic system.
In another mode, as shown in fig. 4, fig. 4 is a schematic diagram illustrating a principle that another illumination system performs laser irradiation on an object to be imaged in an embodiment of the present invention, in this mode, a laser pulse generated by the laser 1 irradiates the object to be imaged through a free optical path illumination system; the free light path illumination system includes: the laser imaging device comprises a diffuser 16, a conical lens 17 and a condenser 18, wherein laser pulses generated by the laser 1 sequentially pass through the diffuser 16, the conical lens 17 and the condenser 18 to irradiate the object 4 to be imaged.
The three-dimensional phased array ultrasonic transducer 6 comprises a plurality of ultrasonic transducer array elements 20; each ultrasonic transducer array element 20 collects a path of photoacoustic signal, and each path of photoacoustic signal corresponds to a signal processing channel. The photoacoustic signal generated by the object 4 to be imaged is transmitted to a three-dimensional space through a coupling medium 5, and is finally captured and collected by a three-dimensional phased array ultrasonic transducer 6, wherein the coupling medium 5 can be air, a liquid medium or a solid medium. The synchronization between the laser 1 and the multi-channel data acquisition circuit 10 is realized by a trigger signal 16 of the laser 1.
The multi-channel data acquisition circuit 10 is a high-speed parallel data acquisition circuit. The multi-channel data acquisition circuit 10 includes: a multi-channel amplifier 7, a multi-channel filter 8 and a multi-channel analog-to-digital converter 9; each ultrasonic transducer array element 20 individually corresponds to one channel, and the photoacoustic signals collected by the ultrasonic transducer array elements 20 are sequentially amplified, filtered and subjected to analog-to-digital conversion through the corresponding channels, and then are sent to the computer 14. Optionally, a time division multiplexer is provided between the multichannel data acquisition circuit 10 and the three-dimensional phased array ultrasonic transducer 6, and the time division multiplexer is used for time-sharing acquisition of multichannel signals. The time division multiplexer is not shown in fig. 1.
In fig. 2 and the manner shown, the columnar substrate 21 has a through hole penetrating through the top and bottom surfaces thereof, and the ultrasonic transducer array elements 20 are fixed on the inner wall of the through hole. In other ways, the ultrasonic transducer array elements 20 may be fixed on the outer side surface of the cylindrical substrate 21, and in this case, the cylindrical substrate 21 may be a solid cylinder or a hollow cylinder. The columnar substrate 21 has opposite top and bottom surfaces and side surfaces, and the axis thereof is the line connecting the midpoint of the top surface and the midpoint of the bottom surface, and the top surface and the bottom surface are the same. The columnar substrate 21 may be a cylinder or a square column. While the conventional matrix transducer is shown in fig. 3, fig. 3 is a schematic structural diagram of a conventional planar array multi-row photoacoustic transducer, which can only receive photoacoustic signals in a specific plane and perform two-dimensional tomographic imaging, the three-dimensional phased array ultrasonic transducer 6 implemented by the invention has a plurality of rows of ultrasonic transducer elements 20 surrounding the axis of a columnar substrate 21, can collect photoacoustic signals propagating in a three-dimensional space, is not limited to photoacoustic signals in a specific plane, can capture photoacoustic signals propagating in a three-dimensional space at one time to obtain a three-dimensional volume image of an object 4 to be imaged, and can realize multi-row photoacoustic imaging to obtain a three-dimensional volume image of the object 4 to be imaged.
As shown in fig. 2, the columnar substrate 21 includes a plurality of detachable sub-columnar substrates 110; at least one row of the ultrasonic transducer array elements 20 is disposed on the sub-cylindrical substrate 110. Optionally, a row of the ultrasonic transducer array elements 20 is disposed on each of the sub-cylindrical substrates 110, and the number and distribution of the ultrasonic transducer array elements 20 on the sub-cylindrical substrates 110 are the same. On the columnar substrate 21, the ultrasonic transducer array elements 20 form a three-dimensional phased array, a certain interval is provided between two adjacent ultrasonic transducer array elements 20, and the ultrasonic transducer array elements 20 can work independently.
Optionally, the photoacoustic imaging system further comprises: and the mechanical scanning device is used for driving the object 4 to be imaged or the three-dimensional phased array ultrasonic transducer 6 to translate along the axis or rotate around the axis. The mechanical scanning device is not shown in fig. 1. Through the relative motion of the object 4 to be imaged and the three-dimensional phased array ultrasonic transducer 6, the whole object 4 to be imaged can be scanned, and the whole photoacoustic imaging can be performed on the whole object 4 to be imaged.
In the photoacoustic imaging system, the computer 14 includes: a three-dimensional image reconstruction system 11, a three-dimensional image processing system 12, and a three-dimensional image display system 13.
In the photoacoustic imaging system according to the embodiment of the present invention, nanosecond laser emitted from a high-energy pulse laser is used to excite an object 4 to be imaged, an absorber in the object 4 to be imaged absorbs laser energy to instantaneously generate temperature rise, and due to a thermoelastic effect, an ultrasonic signal (photoacoustic signal) is generated and transmitted to a three-dimensional space. The three-dimensional phased array ultrasonic transducer 6 with high-density multi-row ultrasonic transducer array elements 20 is used for receiving photoacoustic signals in a three-dimensional space, low-noise amplification, filtering and telling parallel analog-to-digital conversion processing are carried out on the captured multichannel photoacoustic signals, and finally, reconstruction, processing and display are carried out on images, so that the three-dimensional space distribution of an absorber in the object 4 to be imaged can be restored.
Multispectral imaging is performed by scanning laser wavelength, so that noninvasive characterization of chemical components of a sample can be realized. Due to different absorption spectra of different molecules, different molecules can be separated from the multispectral image by using a spectral unmixing algorithm, and molecular specific imaging is realized. Because the ultrasonic signals generated by different objects to be imaged 4 after absorbing laser energy have different frequencies, parameters reflecting physical properties of the sample, including slope, intercept and the like, can be obtained by performing spectrum analysis on the ultrasonic signals received by the three-dimensional phased array ultrasonic transducer 6, and further noninvasive characterization of the sample is realized. By analyzing the frequency spectrum of the ultrasonic signals received by the three-dimensional phased array ultrasonic transducer 6 with the high-density multi-row ultrasonic transducer array elements 20, the non-invasive characterization of the physical properties of the object 4 to be imaged can be realized.
The GPU is used for accelerating, so that the processing speed of multi-channel signals and images can be improved. Real-time processing and image reconstruction of multi-channel high-dimensional signals generated in the system can be realized by adopting a GPU acceleration method. The GPU accelerated hardware may be implemented using a GPU graphics card (e.g., NVIDIATesla series) having multiple streaming processors, each configured with multiple processing cores. The GPU acceleration software can be implemented by using a C language-based CUDA (computer Unified Device architecture) parallel computing architecture. CUDA parallel computing programs typically contain one host program and multiple threads. The host program is first executed by the central processing unit CPU and subsequently starts the respective calculation threads simultaneously.
When photoacoustic imaging is performed, a photoacoustic signal of the object 4 to be imaged excited by laser light propagates in a three-dimensional space without being limited to a specific plane. The traditional photoacoustic imaging system based on the linear array or the array-changing transducer array can only receive photoacoustic signals in a specific plane to carry out two-dimensional tomography. The photoacoustic imaging system provided by the embodiment of the invention can capture photoacoustic signals transmitted in a three-dimensional space at one time to obtain a three-dimensional volume image of an object 4 to be imaged, can realize multi-row photoacoustic imaging to obtain the three-dimensional volume image of the object 4 to be imaged, can realize three-dimensional volume imaging at one time, simultaneously improves the signal-to-noise ratio, the imaging sensitivity and the imaging quality, and solves the problems that the traditional photoacoustic imaging system can only carry out two-dimensional tomography and the imaging view angle is limited.
In the embodiment of the invention, a simulation experiment is performed on the photoacoustic imaging system to illustrate the advantages of the photoacoustic imaging system in the embodiment of the invention.
In the photoacoustic imaging system according to the embodiment of the present invention, the cylindrical substrate 21 is a cylindrical structure, that is, a cylindrical structure having through holes penetrating through the top surface and the bottom surface is provided, the inner diameter of the cylinder is 50mm, the height of the cylinder is 200mm, the number of rows of the ultrasound transducer array elements 20 in the height direction is 1496, and the number of the ultrasound transducer array elements 20 in the same row is 800. The functional surface of the ultrasonic transducer array element 20 is a rectangle, the height of the rectangle is 0.13mm, the width of the rectangle is 0.16mm, and the distance between the rectangle and the array element is 0.04 mm. The three-dimensional phased array ultrasonic transducer 6 has a center frequency of 7.5MHz, a sensitivity of-6 dB and a bandwidth of about 80%.
In order to study the sound Field distribution characteristics of the three-dimensional phased array ultrasonic transducer 6, simulation was performed using open source software Field II.
Fig. 5 is a sound field distribution diagram of a single ultrasonic transducer array element in a 7.5MHz three-dimensional phased array ultrasonic transducer according to an embodiment of the present invention, fig. 5 is a sound pressure level distribution diagram of a specific one of the ultrasonic transducer array elements 20 in a plane 20mm × 20mm in the three-dimensional phased array ultrasonic transducer 6, as can be seen from fig. 5, a main lobe and a side lobe are present in the sound field.
As shown in fig. 6, fig. 6 is a sound field distribution diagram of a 7.5MHz three-dimensional phased array ultrasonic transducer in a set plane according to an embodiment of the present invention, as can be seen from fig. 6, the sound field distribution of all ultrasonic transducer array elements 20 of the three-dimensional phased array ultrasonic transducer 6 in a specific plane shows that the maximum amplitude of the sound field appears in the center and is distributed symmetrically.
It should be noted that, in order to achieve a relatively ideal reconstruction effect, the three-dimensional phased array ultrasonic transducer 6 for simulation uses a large number of ultrasonic transducer elements 20 in the height direction and the radial direction. In practical use, the limit on the reconstruction artifacts can be relaxed appropriately to reduce the number of ultrasound transducer array elements 20 substantially.
On the basis of the simulation of the three-dimensional phased array ultrasonic transducer 6, the photoacoustic imaging simulation is carried out. In the simulation, the laser 1 is an optical parametric amplification (OPO) laser, the output wavelength ranges are 690-950nm and 1200-2400 nm, the time width of a single pulse is about 6ns, and the repetition frequency is 10 Hz. The numerical simulation (i.e. the simulation model of the object 4 to be imaged) used in the simulation is a three-dimensional small sphere numerical model, which includes 8 small spheres with a diameter of 1.2mm and 1 large sphere with a diameter of 1.6mm, as shown in fig. 7, fig. 7 is a simulation model diagram of the object to be imaged, and the simulation model is a three-dimensional small sphere simulation model. When the laser irradiates the small ball model, an ultrasonic signal is excited to be transmitted to a three-dimensional space. The number of the channels of the multi-channel data acquisition circuit 10 is 256, the highest sampling rate of the single channel is 62.5MS/s, and the acquisition precision is 14 bit. Fig. 8 is a diagram of the photoacoustic field spatial distribution generated around the three-dimensional globule at a time of 1.0 microsecond. Fig. 9 is a photoacoustic signal distribution diagram acquired by a simulated three-dimensional phased array ultrasonic transducer, and in fig. 9, the horizontal axis is time and the vertical axis is the number of array elements of the transducer. Fig. 10 is a three-dimensional bead image reconstructed using a back projection algorithm. Therefore, the photoacoustic imaging system can accurately realize the three-dimensional imaging of the object.
Based on the photoacoustic imaging system, another embodiment of the present invention further provides a photoacoustic imaging method, which can be implemented by the photoacoustic imaging system according to the above embodiment, and specifically, the photoacoustic imaging method includes:
step S11: the laser pulse emitted by the laser irradiates the object to be imaged, and the object to be imaged is excited to generate a photoacoustic signal which is transmitted to a three-dimensional space through a thermoelastic effect.
The high-energy pulse laser can be adopted to emit nanosecond laser to excite the object to be imaged, so that an absorber in the object to be imaged absorbs laser energy, the temperature is raised instantly, and pressure ultrasonic signals (photoacoustic signals) are generated due to the thermoelastic effect and are transmitted to a three-dimensional space.
Step S12: and acquiring the photoacoustic signal propagated to a three-dimensional space by using a three-dimensional phased array ultrasonic transducer.
The photoacoustic signal propagated in the three-dimensional space is received by using a three-dimensional phased array ultrasonic transducer 6 with a plurality of rows of high-density ultrasonic transducer array elements 20, and the signal reception is triggered by a synchronous signal output by a laser.
Step S13: and performing signal processing on the photoacoustic signal acquired by the three-dimensional phased array ultrasonic transducer through a multi-channel data acquisition circuit.
In the step, the acquired multichannel photoacoustic signals are subjected to low-noise amplification, filtering and high-speed parallel analog-to-digital conversion and then transmitted to a computer for photoacoustic imaging.
Step S14: and forming a three-dimensional photoacoustic image of the object to be imaged based on the photoacoustic signal after the signal processing by a computer.
And carrying out image reconstruction, image processing and image display on the discrete photoacoustic signals through a computer, and restoring the three-dimensional space distribution of the absorber in the sample.
In the photoacoustic imaging method according to the embodiment of the present invention, the laser wavelength emitted by the laser may be adjusted, and multispectral imaging may be performed by scanning the laser wavelength in the ultraviolet, visible, and near-infrared wavelength ranges, and non-invasive characterization of chemical components of an object to be imaged is performed based on a spectral image, that is, the object to be imaged is scanned by laser of a corresponding wavelength band, and after signal processing is performed on the photoacoustic signal acquired by the three-dimensional phased array ultrasonic transducer by the multichannel data acquisition circuit, a computer may perform multispectral imaging based on the photoacoustic signal after the signal processing.
The photoacoustic imaging method provided by the embodiment of the invention can perform spectrum analysis on ultrasonic signals received by a plurality of rows of ultrasonic transducer array elements in the three-dimensional phased array ultrasonic transducer in a Fourier domain, perform non-invasive characterization on the physical properties of the object to be imaged based on the spectrum analysis result, and perform spectrum analysis on the photoacoustic signals acquired by the three-dimensional phased array ultrasonic transducer through the computer, so that the non-invasive characterization on the physical properties of the object to be imaged can be realized.
The photoacoustic imaging method provided by the embodiment of the invention can improve the processing speed of multi-channel signals and images in the photoacoustic imaging system by a GPU acceleration method.
The embodiments in the present description are described in a progressive manner, or in parallel, or in a combination of progressive manner and parallel manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments may be referred to each other. The method disclosed by the embodiment corresponds to the system disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the system part for description.
It is further noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that an article or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such article or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in an article or device that comprises the element.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A photoacoustic imaging system, characterized in that the photoacoustic imaging system comprises:
the laser is used for emitting laser pulses to irradiate the object to be imaged, and the object to be imaged is excited to generate a photoacoustic signal which propagates to a three-dimensional space through a thermoelastic effect;
a three-dimensional phased array ultrasonic transducer for acquiring the photoacoustic signal propagating into a three-dimensional space; the three-dimensional phased array ultrasonic transducer is provided with a columnar substrate, an ultrasonic transducer array is fixed on the columnar substrate and comprises a plurality of rows of ultrasonic transducer array elements surrounding the central axis of the columnar substrate, and the ultrasonic transducer array can capture photoacoustic signals transmitted in a three-dimensional space at one time, realize a plurality of rows of photoacoustic imaging and obtain a three-dimensional volume image of an object to be imaged; the central axis is a connecting line of the midpoint of the top surface and the midpoint of the bottom surface of the columnar substrate;
a multi-channel data acquisition circuit for performing signal processing on the photoacoustic signals acquired by the three-dimensional phased array ultrasonic transducer; a time division multiplexer is arranged between the multichannel data acquisition circuit and the three-dimensional phased array ultrasonic transducer, and the time division multiplexer is used for time-sharing acquisition of multichannel signals;
a computer for forming a three-dimensional photoacoustic image of the object to be imaged based on the photoacoustic signals after signal processing;
wherein the three-dimensional phased array ultrasonic transducer comprises a plurality of ultrasonic transducer array elements;
the multichannel data acquisition circuit includes: the system comprises a multi-channel amplifier, a multi-channel filter and a multi-channel analog-to-digital converter; each ultrasonic transducer array element corresponds to one channel independently, and the ultrasonic transducer array elements acquire the photoacoustic signals, sequentially amplify, filter and convert analog to digital through the corresponding channels and then send the photoacoustic signals to the computer;
the columnar substrate comprises a plurality of detachable sub-columnar substrates; at least one row of ultrasonic transducer array elements are arranged on the sub-columnar substrate;
the number and the distribution of the ultrasonic transducer array elements on the sub-columnar substrate are the same;
the laser is a laser with adjustable wavelength, the wavelength of the laser is in the ultraviolet, visible light and infrared wavelength ranges, the laser is also used for scanning the laser wavelength to irradiate the object to be imaged and exciting the object to be imaged to generate an ultrasonic signal propagating to a three-dimensional space through a thermoelastic effect, the three-dimensional phased array ultrasonic transducer is also used for receiving the ultrasonic signal, the multi-channel data acquisition circuit is also used for processing the ultrasonic signal acquired by the three-dimensional phased array ultrasonic transducer, the computer is also used for performing multi-spectral imaging based on the ultrasonic signal after signal processing, and non-invasive characterization of chemical components of the object to be imaged is performed based on a spectral image.
2. The photoacoustic imaging system of claim 1 wherein the laser pulses generated by the laser illuminate the object to be imaged through a fiber optic illumination system;
wherein the fiber optic illumination system comprises: the optical fiber coupler and the multi-path optical fiber bundle; one end of the optical fiber bundle is coupled to a laser output port of the laser through the optical fiber coupler, the other ends of the multiple optical fiber bundles are distributed on the same circumference, and the circumference surrounds the object to be imaged to provide uniform illumination for the object to be imaged.
3. The photoacoustic imaging system of claim 1 wherein the laser pulses generated by the laser illuminate the object to be imaged through a free path illumination system;
the free light path illumination system includes: the laser device comprises a diffuser, a conical lens and a condenser, wherein laser pulses generated by the laser device sequentially pass through the diffuser, the conical lens and the condenser to irradiate the object to be imaged.
4. The photoacoustic imaging system of claim 1 wherein the cylindrical substrate has through holes through its top and bottom surfaces, and the ultrasound transducer array elements are each secured to an inner wall of the through holes.
5. The photoacoustic imaging system of claim 1 wherein the ultrasound transducer array elements are each fixed to an outer side of the cylindrical substrate.
6. The photoacoustic imaging system of claim 1, further comprising: and the mechanical scanning device is used for driving the object to be imaged or the three-dimensional phased array ultrasonic transducer to translate along the central axis or rotate around the central axis.
7. A method of photoacoustic imaging using the photoacoustic imaging system of claim 1, the method comprising:
irradiating an object to be imaged by laser pulses emitted by a laser, and exciting the object to be imaged to generate photoacoustic signals which are transmitted to a three-dimensional space by a thermoelastic effect;
acquiring the photoacoustic signal propagating to a three-dimensional space through a three-dimensional phased array ultrasonic transducer;
performing signal processing on the photoacoustic signal acquired by the three-dimensional phased array ultrasonic transducer through a multi-channel data acquisition circuit;
forming a three-dimensional photoacoustic image of the object to be imaged based on the photoacoustic signal after signal processing by a computer;
wherein the three-dimensional phased array ultrasonic transducer comprises a plurality of ultrasonic transducer array elements;
the multichannel data acquisition circuit includes: the system comprises a multi-channel amplifier, a multi-channel filter and a multi-channel analog-to-digital converter; each ultrasonic transducer array element corresponds to one channel independently, and the ultrasonic transducer array elements acquire the photoacoustic signals, sequentially amplify, filter and convert analog to digital through the corresponding channels and then send the photoacoustic signals to the computer;
further comprising:
in the ultraviolet, visible and infrared wavelength ranges, the laser wavelength is scanned to irradiate the object to be imaged, the object to be imaged is excited to generate an ultrasonic signal which propagates to a three-dimensional space through a thermoelastic effect, multispectral imaging is carried out, and non-invasive characterization of chemical components of the object to be imaged is carried out based on a spectral image.
8. The method of claim 7, further comprising:
carrying out spectrum analysis on ultrasonic signals received by a plurality of rows of ultrasonic transducer array elements in the three-dimensional phased array ultrasonic transducer in a Fourier domain, and carrying out non-invasive characterization on the physical properties of the object to be imaged based on the result of the spectrum analysis;
or, the processing speed of the collected multi-path photoacoustic signals and images is improved by a GPU acceleration method.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910784911.0A CN110367942B (en) | 2019-08-23 | 2019-08-23 | Photoacoustic imaging system and method |
| PCT/CN2020/110196 WO2021036897A1 (en) | 2019-08-23 | 2020-08-20 | Photoacoustic imaging system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910784911.0A CN110367942B (en) | 2019-08-23 | 2019-08-23 | Photoacoustic imaging system and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110367942A CN110367942A (en) | 2019-10-25 |
| CN110367942B true CN110367942B (en) | 2021-03-09 |
Family
ID=68260580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910784911.0A Active CN110367942B (en) | 2019-08-23 | 2019-08-23 | Photoacoustic imaging system and method |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN110367942B (en) |
| WO (1) | WO2021036897A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110367942B (en) * | 2019-08-23 | 2021-03-09 | 中国科学技术大学 | Photoacoustic imaging system and method |
| CN111035368B (en) * | 2020-01-07 | 2022-12-13 | 上海科技大学 | Single-channel real-time photoacoustic tomography imaging system and method |
| CN113116296A (en) * | 2020-01-13 | 2021-07-16 | 香港城市大学深圳研究院 | Photoacoustic and ultrasonic collaborative diagnosis and treatment system |
| WO2021237417A1 (en) * | 2020-05-25 | 2021-12-02 | 中国科学院深圳先进技术研究院 | Panoramic light follow-up apparatus and photoacoustic imaging system thereof |
| CN111772581B (en) * | 2020-06-11 | 2023-03-28 | 华南师范大学 | High-sensitivity photoacoustic/ultrasonic dual-mode imaging device and method based on double-curvature linear array detector |
| CN111948147B (en) * | 2020-09-25 | 2023-07-25 | 广东工业大学 | Non-blind area full-field ultrasonic microscope imaging system and method thereof |
| WO2022104701A1 (en) * | 2020-11-20 | 2022-05-27 | 深圳先进技术研究院 | Ultrasound probe, endoscope, endoscopic imaging system, and endoscopic imaging method |
| CN112505668B (en) * | 2020-12-01 | 2024-02-13 | 中国人民解放军海军工程大学 | Phased array focusing system for laser-induced acoustic emission |
| CN112890856A (en) * | 2020-12-31 | 2021-06-04 | 江苏霆升科技有限公司 | Two-dimensional ultrasonic transducer array for ultrasonic imaging, imaging method and device |
| CN113545747B (en) * | 2021-06-01 | 2024-04-12 | 广东省科学院健康医学研究所 | Laser speckle-photoacoustic combined imaging device and implementation method thereof |
| CN113607652B (en) * | 2021-08-11 | 2022-06-24 | 电子科技大学 | Workpiece superficial layered imaging method based on photoacoustic spectrum |
| CN114209282A (en) * | 2021-12-22 | 2022-03-22 | 复旦大学 | Ultrasonic and photoacoustic multi-mode high-resolution three-dimensional scanning imaging device |
| CN114563479B (en) * | 2022-04-20 | 2022-08-30 | 之江实验室 | Real-time three-dimensional high-resolution terahertz photoacoustic imaging method and device |
| CN114964361B (en) * | 2022-04-26 | 2023-10-10 | 南京大学 | Ocean photoacoustic tomography method and system based on DAS |
| CN115040083B (en) * | 2022-06-24 | 2023-03-10 | 苏州芙迈蕾医疗科技有限公司 | Photoacoustic tomography and ultrasonic imaging system and method based on multiple ultrasonic transducers |
| CN118603895A (en) * | 2024-08-01 | 2024-09-06 | 西安电子科技大学 | Photoacoustic imaging device and method based on multi-wavelength LED excitation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201233362Y (en) * | 2008-06-04 | 2009-05-06 | 江西农业大学 | Multi optical spectrum imaging device for detecting fruit quality |
| CN205411151U (en) * | 2016-02-18 | 2016-08-03 | 湖南工业大学 | Ultrafast optoacoustic image device based on array detector |
| CN106175691A (en) * | 2016-08-26 | 2016-12-07 | 凌斌 | Flexible substrates MEMS curved array photoacoustic imaging system |
| CN108042110A (en) * | 2017-12-22 | 2018-05-18 | 深圳先进技术研究院 | Multi-modality imaging system |
| CN109171816A (en) * | 2018-09-05 | 2019-01-11 | 中北大学 | It is a kind of for checking the ultrasonic CT system and its scan method of mammary gland |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5984542B2 (en) * | 2011-08-08 | 2016-09-06 | キヤノン株式会社 | Subject information acquisition apparatus, subject information acquisition system, display control method, display method, and program |
| US20160022150A1 (en) * | 2014-07-24 | 2016-01-28 | Canon Kabushiki Kaisha | Photoacoustic apparatus |
| CN105249933A (en) * | 2015-11-20 | 2016-01-20 | 哈尔滨海鸿基业科技发展有限公司 | Photo-acoustic molecule three-dimensional image instrument |
| CN105395170B (en) * | 2015-12-15 | 2018-07-27 | 同济大学 | A kind of photoacoustic ultrasound bimodal synchronous imaging system |
| CN109953771A (en) * | 2016-06-27 | 2019-07-02 | 中国科学院苏州生物医学工程技术研究所 | Ultrasonic imaging method, ultrasonic elastograph imaging method and miniature ultrasonic device |
| US10760956B2 (en) * | 2016-07-05 | 2020-09-01 | Canon Kabushiki Kaisha | Wavefront control apparatus, wavefront control method, information acquiring apparatus, and storage medium |
| CN107607473B (en) * | 2017-08-31 | 2020-05-19 | 华南师范大学 | Simultaneous multipoint excitation and matching received photoacoustic three-dimensional imaging device and method |
| CN109363645B (en) * | 2018-10-29 | 2021-04-13 | 中国科学院上海技术物理研究所 | Human body blood vessel detection method based on laser photoacoustic spectroscopy |
| CN110367942B (en) * | 2019-08-23 | 2021-03-09 | 中国科学技术大学 | Photoacoustic imaging system and method |
| CN110367943A (en) * | 2019-08-23 | 2019-10-25 | 中国科学技术大学 | Phase array transducer and ultrasound phase-control detection system |
-
2019
- 2019-08-23 CN CN201910784911.0A patent/CN110367942B/en active Active
-
2020
- 2020-08-20 WO PCT/CN2020/110196 patent/WO2021036897A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201233362Y (en) * | 2008-06-04 | 2009-05-06 | 江西农业大学 | Multi optical spectrum imaging device for detecting fruit quality |
| CN205411151U (en) * | 2016-02-18 | 2016-08-03 | 湖南工业大学 | Ultrafast optoacoustic image device based on array detector |
| CN106175691A (en) * | 2016-08-26 | 2016-12-07 | 凌斌 | Flexible substrates MEMS curved array photoacoustic imaging system |
| CN108042110A (en) * | 2017-12-22 | 2018-05-18 | 深圳先进技术研究院 | Multi-modality imaging system |
| CN109171816A (en) * | 2018-09-05 | 2019-01-11 | 中北大学 | It is a kind of for checking the ultrasonic CT system and its scan method of mammary gland |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110367942A (en) | 2019-10-25 |
| WO2021036897A1 (en) | 2021-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110367942B (en) | Photoacoustic imaging system and method | |
| US20220054017A1 (en) | Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use | |
| Dima et al. | Multispectral optoacoustic tomography at 64, 128, and 256 channels | |
| Gateau et al. | Three‐dimensional optoacoustic tomography using a conventional ultrasound linear detector array: Whole‐body tomographic system for small animals | |
| JP5294998B2 (en) | Ultrasonic probe, photoacoustic / ultrasonic system including the ultrasonic probe, and specimen imaging apparatus | |
| CN105595964B (en) | Double focusing ultrasonic probe and thinned array Photoacoustic tomography system | |
| CN1211650C (en) | NIR clinical opti-scan system | |
| EP2859326B1 (en) | Imaging system and method for imaging an object | |
| CN100446730C (en) | Photoacoustic imaging and chromatographic imaging method based on acoustic lens and apparatus thereof | |
| US6795195B1 (en) | System and method for tomographic imaging of dynamic properties of a scattering medium | |
| CN102822661A (en) | Photoacoustic imaging apparatus and photoacoustic imaging method | |
| WO2010127199A2 (en) | System for photoacoustic imaging and related methods | |
| JP2009207883A (en) | Biological information imaging apparatus and biological information analyzing method | |
| JP2013500091A5 (en) | ||
| US20130190594A1 (en) | Scanning Optoacoustic Imaging System with High Resolution and Improved Signal Collection Efficiency | |
| USRE41949E1 (en) | System and method for tomographic imaging of dynamic properties of a scattering medium | |
| WO2018087984A1 (en) | Photoacoustic image evaluation device, method, and program, and photoacoustic image generating device | |
| Gao et al. | Acoustic-resolution photoacoustic microscope based on compact and low-cost delta configuration actuator | |
| Thompson et al. | Spatially compounded plane wave imaging using a laser-induced ultrasound source | |
| JP6742745B2 (en) | Information acquisition device and display method | |
| CN109864707A (en) | A method of improving Photoacoustic tomography resolution ratio in limited perspective | |
| CN105249933A (en) | Photo-acoustic molecule three-dimensional image instrument | |
| CN2915036Y (en) | Optical acoustic imaging and tomography device based on acoustical lens | |
| CN111631685A (en) | Photoacoustic PET system and imaging method | |
| JP6005126B2 (en) | Probe unit, photoacoustic / ultrasonic probe, and object imaging system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |