WO2021237417A1

WO2021237417A1 - Panoramic light follow-up apparatus and photoacoustic imaging system thereof

Info

Publication number: WO2021237417A1
Application number: PCT/CN2020/092143
Authority: WO
Inventors: 刘成波; 张迎; 陈涛; 刘良检; 潘殷豪; 陈宁波; 高蓉康; 任亚光
Original assignee: 中国科学院深圳先进技术研究院
Priority date: 2020-05-25
Filing date: 2020-05-25
Publication date: 2021-12-02

Abstract

Provided are a panoramic light follow-up apparatus (30) and a photoacoustic imaging system (100) thereof. The panoramic light follow-up apparatus (30) comprises: a fixing plate (31) provided with N first sliding grooves (311), which are uniformly distributed; a gear turntable (32) arranged on the main plane of one side of the fixing plate (31), the gear turntable (32) being provided with N second sliding grooves (321), which are uniformly distributed, wherein the second sliding grooves (321) are arc-shaped sections extending outwards from a first circumference of the gear turntable (32) to a second circumference of the gear turntable (32); and N groups of optical units (33) arranged on a side of the fixing plate (31) facing away from the gear turntable (32), wherein the optical units (33) are in sliding fit with the gear turntable (32). During the rotation of the gear turntable (32), the gear turntable (32) is used for driving the optical units (33) to synchronously slide in the first sliding grooves (311) and the second sliding grooves (321), so as to adjust an irradiation range of the N groups of optical units (33). In this way, the apparatus can solve the problem of a current photoacoustic imaging apparatus being unable to adjust an illumination area according to the size of a tested sample or a change in the peripheral size thereof so as to adapt to different tested samples.

Description

Panoramic light follower and its photoacoustic imaging system

【Technical Field】

This application relates to the field of photoacoustic imaging technology, and in particular to a panoramic light follow-up device and a photoacoustic imaging system thereof.

【Background technique】

Photoacoustic imaging is a non-destructive medical imaging method developed in recent years. It combines the high contrast characteristics of pure optical imaging and the high penetration depth characteristics of pure ultrasound imaging, which can provide high-resolution and high-contrast tissue imaging. The important thing is that it can realize biological physiological function imaging. For example, photoacoustic imaging technology can be used to measure physiological parameters such as blood oxygen saturation of living organisms.

During the long-term research and development process, the inventor of the present application found that the shape of the optical components of the existing photoacoustic imaging device is fixed and unadjustable, so it is impossible to adjust the illumination area according to the size of the tested sample or the change of its outer circumference to adapt to different tested samples. For samples, the scope of application is relatively small.

[Summary of the invention]

In view of this, the purpose of the embodiments of the present application is to provide a panoramic light follow-up device and a photoacoustic imaging system thereof, so as to solve the problem that the existing photoacoustic imaging device cannot adjust the illumination area according to the size of the tested sample or the change of its outer circumference. Adapt to the problems of different tested samples.

On the one hand, the present application provides a panoramic light follow-up device, which includes: a fixed plate with N first sliding grooves evenly distributed; a gear turntable arranged on one main plane of the fixed plate, and the gear turntable is provided with There are evenly distributed N second sliding grooves, wherein the second sliding groove is an arc segment extending from the first circumference of the gear wheel to the second circumference of the gear wheel; N groups of optical units are arranged on the fixed plate away from One side of the gear wheel, and the optical unit is slidingly matched with the gear wheel; during the rotation of the gear wheel, the gear wheel is used to drive the optical unit to slide synchronously in the first chute and the second chute to adjust the N groups of optics The irradiation range of the unit.

On the other hand, this application provides a photoacoustic imaging system, including: nanosecond pulsed lasers, fiber sub-beams, ultrasonic transducers, high-speed data acquisition boards, precision mechanical scanning platforms, control circuits, and the aforementioned panoramic light follow-up The device, the ultrasonic transducer is set under the panoramic light follower; the nanosecond pulsed laser outputs pulsed laser through the fiber sub-beam; the panoramic light follower is fixed on the precision mechanical scanning platform to scan and irradiate the pulsed laser to biological tissues Generate photoacoustic signals; ultrasonic transducers are used to receive photoacoustic signals and convert them into electrical signals; high-speed data acquisition boards are used to collect electrical signals after signal amplification, and convert the electrical signals after signal amplification into digital signals , Stored in the photoacoustic imaging system.

The beneficial effect of the present application is that, different from the prior art, in the panoramic light follow-up device and the photoacoustic imaging system provided in the embodiments of the present application, the optical unit and the gear wheel are in sliding cooperation, and during the rotation of the gear wheel , The gear wheel is used to drive the optical unit to slide synchronously in the first chute and the second chute to adjust the irradiation range of the N groups of optical units. When the size of the measured sample or its outer circumference changes, the irradiation range of the N groups of optical units can be adjusted adaptively. Therefore, it is possible to realize the measured sample suitable for different outer circumferences or outer circumference changes, and expand the inclusion of panoramic light follow-up devices The scope of application of the photoacoustic imaging system of the existing photoacoustic imaging device makes up for the single and non-adjustable defect of the irradiation range of the existing photoacoustic imaging device, and solves the problem that the existing photoacoustic imaging device cannot adjust the illumination area according to the size of the tested sample or the change in the outer circumference of the photoacoustic imaging device. Adapt to the problems of different tested samples.

【Explanation of the drawings】

In order to explain the technical solutions in the embodiments of the present application more clearly, the following will briefly introduce the drawings needed in the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative work. in:

Fig. 1 is a schematic structural diagram of a first embodiment of a panoramic light follow-up device according to the present application;

Fig. 2 is a schematic diagram of the structure of the fixing plate in Fig. 1;

Fig. 3 is a schematic diagram of the structure of the gear wheel in Fig. 1;

FIG. 4 is a schematic structural diagram of a working state of the panoramic light follow-up device of the present application;

Fig. 5 is a schematic structural diagram of another working state of the panoramic light follower of the present application;

Fig. 6 is a partial structural diagram of a second embodiment of a panoramic light follower of the present application;

FIG. 7 is a schematic diagram of a partial structure at B in FIG. 3;

Fig. 8 is a partial structural diagram of a third embodiment of a panoramic light follower of the present application;

Fig. 9 is a partial structural diagram of a fourth embodiment of a panoramic light follower of the present application;

Fig. 10 is a partial structural diagram of the optical unit in Fig. 1;

FIG. 11 is a schematic diagram of the structure of the optical fiber bundle mounting seat in FIG. 10;

FIG. 12 is a schematic diagram of the structure of the lens unit in FIG. 10;

FIG. 13 is a schematic diagram of a partial structure of the lens unit in FIG. 10;

FIG. 14 is a schematic diagram of a partially disassembled structure of a fifth embodiment of a panoramic light follower of the present application;

15 is a schematic diagram of a partial structure of a sixth embodiment of a panoramic light follower of the present application;

16 is a schematic structural diagram of a seventh embodiment of a panoramic light follower of the present application;

FIG. 17 is a schematic structural diagram of an embodiment of the photoacoustic imaging system of the present application;

FIG. 18 is another schematic structural diagram of an embodiment of the photoacoustic imaging system of the present application.

【Detailed ways】

The technical solutions in the embodiments of the present application will be described clearly and completely in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in this application, all other embodiments obtained by a person of ordinary skill in the art without creative work shall fall within the protection scope of this application.

Referring to FIGS. 1-3, an embodiment of the present application provides a panoramic light follower 30. The panoramic light follower 30 includes a fixed plate 31, a gear wheel 32, N groups of optical units 33, and a drive unit 34. The gear wheel 32 is arranged on one main plane of the fixed plate 31, and the N groups of optical units 33 are arranged on the side of the fixed plate 31 away from the gear wheel 32.

The fixed plate 31 is provided with N first sliding grooves 311 evenly distributed. The gear wheel 32 is provided with N second sliding grooves 321 evenly distributed. The second sliding grooves 321 are arc segments extending from the first circumference of the gear wheel 32 to the second circumference of the gear wheel 32. Wherein, the radius of the first circle is smaller than the radius of the second circle.

Wherein, the optical unit 33 is in sliding cooperation with the gear wheel 32. During the rotation of the gear wheel 32, the gear wheel 32 is used to drive the optical unit 33 to slide synchronously in the first chute 311 and the second chute 321, so as to The irradiation range of the N groups of optical units 33 is adjusted.

As shown in FIG. 4, when the initial state of the optical unit 33 is the state where the irradiation range is reduced to the minimum, the optical unit 33 slides to the end of the second chute 321 in the first circle. At this time, the irradiation range of the optical unit 33 is The radius is at its minimum. The fixing plate 31 is sleeved on the outer circumference of the sample to be tested. As shown in FIG. 5, during the rotation of the gear wheel 32, the optical unit 33 slides toward the end of the second sliding groove 321 in the second circle, so that the optical unit 33 The irradiation range gradually expanded. When the optical unit 33 slides to the other end of the second chute 321 at the second circumference, the radius of the irradiation range of the optical unit 33 is at the maximum state.

Preferably, as shown in FIGS. 1 and 6, the N groups of optical units 33 are evenly distributed on the side of the fixed plate 31 away from the gear wheel 32. At this time, the light of the N groups of optical units 33 is a spatial 360-degree ring light, namely Panoramic light. The vertical distance between each group of optical units 33 and the fixed plate 31 is the same, and the angle between each group of optical units 33 and the fixed plate 31 is also the same. On the same plane.

Different from the prior art, in the panoramic light follow-up device provided by the embodiment of the present application, the optical unit is in sliding cooperation with the gear wheel. During the rotation of the gear wheel, the gear wheel is used to drive the optical unit to slide in the first slide. The slot and the second slide slot slide synchronously to adjust the irradiation range of the N groups of optical units. When the size of the measured sample or its outer circumference changes, the irradiation range of the N groups of optical units can be adjusted adaptively. Therefore, it is possible to realize the measured sample suitable for different outer circumferences or outer circumference changes, and expand the inclusion of panoramic light follow-up devices The scope of application of the photoacoustic imaging system of the existing photoacoustic imaging device makes up for the single and non-adjustable defect of the irradiation range of the existing photoacoustic imaging device, and solves the problem that the existing photoacoustic imaging device cannot adjust the illumination area according to the size of the tested sample or the change in the outer circumference of the photoacoustic imaging device. Adapt to the problems of different tested samples.

In one embodiment, as shown in FIG. 7, the outer edge of the gear wheel 32 is provided with a sector gear portion 320.

Specifically, the gear wheel 32 includes a circular shaft portion (not shown in the figure) and a sector gear portion 320 located on the outer edge of the shaft portion. The central angle α of the sector gear portion 320 is: 30°≤α ≤120°, preferably, the central angle α of the sector gear part 320 is 90°.

As shown in FIGS. 1 and 8, the panoramic light follow-up device 30 further includes a driving unit 34, and the driving unit 34 includes a gear body 341 and a stepping motor 342. The gear body 341 is disposed on the main surface of the fixed plate 31, and the serrations on the outer edge of the gear body 341 are meshed and connected with the sector gear portion 320. The stepping motor 342 is connected to the gear body 341, and the stepping motor 342 is used to drive the gear body 341 to rotate, so that the gear body 341 drives the gear wheel 32 to rotate. Specifically, the stepping motor 342 starts to rotate forward, and the shaft of the stepping motor 342 drives the gear body 341 to rotate.

In this embodiment, by rotating the gear wheel 32 at a small angle, the circumference of the irradiation range of the optical unit 33 can be expanded or reduced, so as to meet the scanning requirements of the tested samples with different outer circumference sizes and changes in outer circumference size.

As shown in Figures 1, 8 and 16, in one embodiment, the panoramic light follow-up device 30 further includes: a number of distance sensors 61 and a control circuit 70, and the control circuit 70 is electrically connected to a number of distance sensors 61 and Stepping motor 342. The distance sensor 61 is used to sense the distance from the measurement sample to the panoramic light follower 30. The control circuit 70 is used to control the stepping motor 342 to drive the gear body 341 to rotate according to the distance sensed by the distance sensor 61 so that the gear body 341 drives the gear wheel 32 to rotate until the irradiation range of the N groups of optical units 33 reaches the target range.

In the above manner, the distance sensor 61 is used to sense the distance between the measurement sample and the panoramic light follower 30, and then the stepping motor 342 is automatically controlled to drive the gear body 341 through the control circuit 70, thereby realizing the illumination range of the N groups of optical units 33 Automatic adjustment.

In an embodiment, referring to FIGS. 1, 9 and 15, the panoramic light follow-up device 30 further includes: N groups of slider units 35 corresponding to the N groups of optical units 33 one-to-one. The slider unit 35 includes a guide rail 351 and a slider body 352.

The guide rails 351 are evenly distributed on the side of the fixed plate 31 away from the gear wheel 32 and are arranged in parallel with the first sliding groove 311.

Specifically, the guide rails 351 are evenly distributed on the side of the fixed plate 31 away from the gear wheel 32 in a ring shape. The guide rail 351 is detachably connected to the fixing plate 31 by screws (not shown in the figure), so that the guide rail 351 is convenient to install and disassemble, and facilitate maintenance.

The slider body 352 is slidably arranged on the guide rail 351, wherein the slider body 352 is connected to the optical unit 33, and the optical unit 33 is slidably connected to the fixed plate 31 through the slider body 352 and the guide rail 351.

Wherein, a convex strip is provided in the middle of the guide rail 351, the slider body 352 is a concave structure, and the convex strip is clamped in the groove of the slider body 352.

In an embodiment, referring to FIGS. 1-3, 9-10, FIG. 15, FIG. 16 and FIG. The panoramic light follower 30 has N optical fiber sub-bundles 201 in total. It should be noted that the N optical fiber sub-bundles 201 in the embodiment of the present application are the ends of a first optical fiber 200 that are bifurcated.

The shape of the bracket 331 is an "h" shape. One end of the bracket 331 penetrates the first sliding groove 311 and the second sliding groove 321. The turntable 32 can drive the optical unit 33 to slide synchronously in the first sliding groove 311 and the second sliding groove 321 through the bracket 331. The other end of the bracket 331 is a clamping mechanism.

The fiber bundle mounting seat 332 is mounted on the clamping mechanism of the bracket 331. The optical fiber bundle mounting seat 332 is used to install the optical fiber sub-bundle 201 and the lens unit 334.

Specifically, the optical fiber bundle mounting seat 332 is detachably connected to the bracket 331 by screws (not shown in the figure), so that the optical fiber bundle mounting seat 332 is convenient to install and disassemble, and facilitate maintenance.

10-11, the fiber bundle mounting seat 332 is provided with a first accommodating cavity 3321 and a second accommodating cavity 3322 that are penetrated and coaxially arranged, and the first accommodating cavity 3321 is used for accommodating the optical fiber sub-bundle 201. One end of the optical fiber sub-bundle 201 is inserted into the first accommodating cavity 3321, and one end of the lens unit 334 is inserted into the second accommodating cavity 3322. The laser light output by the optical fiber sub-bundle 201 can be projected to the measured object through the light transmission hole 3343 of the lens unit 334. To form a light spot on the sample.

Specifically, the fiber bundle mounting seat 332 is provided with a first accommodating cavity 3321 and a second accommodating cavity 3322. The first accommodating cavity 3321 and the second accommodating cavity 3322 penetrate the front and rear surfaces of the fiber bundle mounting seat 332, and the fiber bundle mounting seat 332 A rectangular opening (not shown in the figure) is opened in the middle of the upper surface. The rectangular opening is connected to the first accommodating cavity 3321 and the second accommodating cavity 3322. A base plate (not shown in the figure) is fixedly installed on the base plate, a V-shaped groove (not shown in the figure) is provided on the surface of the base plate along the length of the plate, and both sides of the fiber bundle mounting seat 332 are provided with Inlet hole (not shown in the figure), the rectangular opening is provided with a pressure block (not shown in the picture), and the lower surface of the pressure block is provided with a semicircular limit groove (not shown in the picture) corresponding to the position of the V-shaped groove Out), both ends of the side surface of the pressure block are fixedly provided with a stop block (not shown in the figure) of an integrated structure, and both ends of the inner surface of the rectangular opening are provided with sliding notches (not shown in the figure) to limit the position The blocks are all slidably connected with the sliding groove opening. Among them, the cross section of the V-shaped groove can be a U-shaped groove or a V-shaped groove.

In the prior art, because the distribution of the laser light entering the fiber sub-bundle is not completely symmetrical, coupled with the total reflection waveguide form when the laser is transmitted in the fiber sub-bundle, it is determined that there must be a certain divergence angle after the laser is emitted. After dozens of optical fiber sub-bundles are integrated into a single optical fiber, it is obvious that defects such as uneven brightness of the light spot, dark spots, and large far-field divergence angle are exposed. In order to solve the above problems, the present embodiment adopts the lens unit 334 to achieve high-quality laser output with high power, high brightness, uniform laser intensity distribution, and good collimation.

Referring to FIGS. 12 and 13, in an embodiment, the lens unit 334 includes a beam shaping lens (not shown in the figure), and a first housing 3341 and a second housing 3342 connected as a whole, and the beam shaping lens includes a convex lens (Not shown in the figure), a first concave lens (not shown in the figure) and a second concave lens (not shown in the figure). The first concave lens and the second concave lens are arranged in an array.

The first housing 3341 is provided with a boss 3344 protruding in a direction away from the second housing 3342, and the boss 3344 is used to clamp the optical fiber sub-bundle 201. The inner wall of the second housing 3342 is formed with three hole sections 3345 connected back and forth in sequence. The convex lens, the first concave lens and the second concave lens are sequentially installed in the three hole sections 3345. The convex lens, the first concave lens, the second concave lens, and the transparent The holes 3343 are aligned one by one to ensure that the centers of the convex lens, the first concave lens, and the second concave lens are facing the light-transmitting hole 3343.

Continuing to refer to Figures 8, 10, 11, 12 and 13, specifically, the stepping motor 342 drives the gear body 341 to rotate, the gear body 341 drives the gear wheel 32 to rotate, and the gear wheel 32 drives the bracket 331 through one end of the bracket 331 The reciprocating movement is performed on the guide rail 351, thereby driving the fiber bundle mounting seat 332 and the lens unit 334 to move, thereby changing the size of the irradiation range of the fiber sub-bundle 201.

In one embodiment, the panoramic light follow-up device 30 further includes: a limit support bearing (not shown in the figure), and the limit support bearing is used to limit and support the gear wheel 32. The limit support bearing includes: the first sub limit support bearing (not shown in the figure), the second sub limit support bearing (not shown in the figure) and the third sub limit support bearing (not shown in the figure) . The first sub-limiting support bearing and the second sub-limiting support bearing are fixed on the fixing plate 31, the third sub-limiting support bearing is fixed on the top of the bracket 331, and the third sub-limiting support bearing is a flange bearing.

Referring to FIG. 14, in one embodiment, a first through hole 301 is opened on the fixed plate 31, a second through hole 302 is opened on the gear wheel 32, and the first through hole 301 and the second through hole 302 pass through. The hole 301 and the second through hole 302 are used to sleeve the outer circumference of the sample to be tested. The diameters of the first through hole 301 and the second through hole 302 are both greater than or equal to 20 cm.

Referring to FIG. 15, in the above embodiment, the angle between the optical unit 33 and the fixing plate 31 is 45 degrees. Specifically, the angle between the optical axis of the optical fiber bundle mounting seat 332 and the lens unit 334 and the fixing plate 31 is equal Is 45 degrees.

In the foregoing embodiment of the present application, N≥2, preferably, N is 8, 10 or 12.

The embodiment of the present application provides a photoacoustic imaging system. Referring to FIGS. 16 and 17, the photoacoustic imaging system 100 includes: a nanosecond pulsed laser 10, an optical fiber bundle (including a first optical fiber 200 and an optical fiber sub-bundle 201), and high-speed data The acquisition board 40, the precision mechanical scanning platform 50, the ultrasonic transducer 60, the control circuit 70 and the panoramic light follower 30 of the above-mentioned embodiment, the ultrasonic transducer is arranged under the panoramic light follower 30.

The nanosecond pulse laser 10 is used to output pulsed laser light. The panoramic light follower 30 is used to scan the photoacoustic signal generated by the pulsed laser irradiating the biological tissue. The ultrasonic transducer 60 is used to receive photoacoustic signals and convert them into electrical signals. The high-speed data acquisition board 40 is used to collect the amplified electrical signal, convert the amplified electrical signal into a digital signal, and store it in the photoacoustic imaging system 100.

Wherein, the photoacoustic imaging system 100 further includes: a precision mechanical scanning platform 50, a panoramic light follower 30 and an ultrasonic transducer 60 are fixed in the precision mechanical scanning platform 50.

Specifically, the pulsed laser output from the nanosecond pulse laser 10 is reflected twice by a mirror (not shown in the figure) and then collimated and contracted by two convex lenses with different focal lengths (not shown in the figure), and finally passes through An optical fiber coupler (not shown in the figure) is coupled to the first optical fiber 200, wherein the ends of the first optical fiber 200 are bifurcated into N optical fiber sub-bundles 201, and the ends of the optical fiber sub-bundles 201 are respectively fixed to the panoramic light follower 30 of the fiber bundle mounting seat 332.

Continuing to refer to Figures 8 and 15-16, the panoramic light follower 30 and the ultrasonic transducer 60 are assembled and fixed on the precision mechanical scanning platform 50, and the tested sample is fixed on the experimental platform and placed on the ultrasonic transducer 60 In the middle, with the scanning movement of the precision mechanical scanning platform 50, at the same time the driving unit 34 in the panoramic light follower 30 starts to work. The input motor 342 drives the gear body 341 to rotate, and the gear body 341 drives the gear wheel 32 to rotate. The gear wheel 32 drives the bracket 331 to reciprocate on the guide rail 351 through one end of the bracket 331, thereby driving the fiber bundle mounting seat 332 and the lens unit 334 to move. Thus, the size of the irradiation range of the optical fiber sub-bundle 201 is changed.

Different from the state of the art, in the photoacoustic imaging system provided by the embodiment of the present application, the optical unit is in sliding cooperation with the gear wheel. During the rotation of the gear wheel, the gear wheel is used to drive the optical unit in the first chute. , Synchronous sliding in the second chute to adjust the irradiation range of the N groups of optical units. When the size of the measured sample or its outer circumference changes, the irradiation range of the N groups of optical units can be adjusted adaptively. Therefore, it is possible to realize the measured sample suitable for different outer circumferences or outer circumference changes, and expand the inclusion of panoramic light follow-up devices The scope of application of the photoacoustic imaging system of the existing photoacoustic imaging device makes up for the single and non-adjustable defect of the irradiation range of the existing photoacoustic imaging device, and solves the problem that the existing photoacoustic imaging device cannot adjust the illumination area according to the size of the tested sample or the change in the outer circumference of the photoacoustic imaging device. Adapt to the problems of different tested samples.

In one embodiment, the nanosecond pulse laser 10 is used to output laser pulses with a pulse width of nanoseconds to excite photoacoustic signals. The ultrasonic transducer 60 is used to receive photoacoustic signals and convert the photoacoustic signals into electrical signals. The high-speed data acquisition board 40 is used to digitally process the electrical signals and store them in the system.

In an embodiment, the ultrasonic transducer 60 includes two oppositely spliced semi-annular sub-ultrasonic transducers.

Continuing to refer to FIGS. 8 and 16, the number of distance sensors 61 can be 12, and the distance sensors 61 are evenly distributed and fixed on the ultrasonic transducer 60.

During use, the panoramic light follower 30 needs to be fixed directly above the ultrasonic transducer 60, and then the sample to be tested is placed in the middle of the ultrasonic transducer 60, and the panoramic light follower 30 is set on the tested sample. The outer circumference of the sample. At this time, the distance sensor 61 measures the distance from the sample to be tested to the ultrasonic transducer 60, and the drive unit 34 drives the gear wheel 32 to rotate so that the light spots of the N groups of optical units 33 just hit the outer periphery of the sample to be tested, so as to avoid being damaged. The difference in the outer circumference of the test sample affects the quality of the light spot, which provides an important guarantee for the quality of photoacoustic imaging.

Different from the prior art, in the panoramic light follow-up device and the photoacoustic imaging system provided in the embodiments of the present application, the optical unit is in sliding cooperation with the gear wheel. During the rotation of the gear wheel, the gear wheel is used to drive the optics. The unit slides synchronously in the first chute and the second chute to adjust the irradiation range of the N groups of optical units. When the size of the measured sample or its outer circumference changes, the irradiation range of the N groups of optical units can be adjusted adaptively. Therefore, it is possible to realize the measured sample suitable for different outer circumferences or outer circumference changes, and expand the inclusion of panoramic light follow-up devices The scope of application of the photoacoustic imaging system of the existing photoacoustic imaging device makes up for the single and non-adjustable defect of the irradiation range of the existing photoacoustic imaging device, and solves the problem that the existing photoacoustic imaging device cannot adjust the illumination area according to the size of the tested sample or the change in the outer circumference of the photoacoustic imaging device. Adapt to the problems of different tested samples. The above are only examples of this application, and do not limit the scope of this application. Any equivalent structure or equivalent process transformation made by using the content of the description and drawings of this application, or directly or indirectly applied to other related technical fields, The same reasoning is included in the scope of patent protection of this application.

Claims

A panoramic light follow-up device, which includes:

The fixed plate is provided with N first chutes evenly distributed;

The gear turntable is arranged on one main plane of the fixed plate. The gear turntable is provided with N second sliding grooves evenly distributed, wherein the second sliding grooves are from the first An arc-shaped segment extending from the circumference outward to the second circumference of the gear wheel;

N groups of optical units are arranged on the side of the fixed plate away from the gear wheel, and the optical units and the gear wheel are slidingly fitted;

During the rotation of the gear wheel, the gear wheel is used to drive the optical unit to slide synchronously in the first chute and the second chute, so as to adjust the illumination of the N groups of the optical units Scope.
The panoramic light follow-up device according to claim 1, wherein:

A sector gear part is provided on the outer edge of the gear wheel;

The panoramic light follow-up device further includes: a driving unit;

The driving unit includes:

A gear body, which is arranged on the main surface of the fixed plate, and the serrations of the outer periphery of the gear are in meshing connection with the sector gear part;

The stepping motor is connected with the gear body and is used to drive the gear body to rotate so that the gear body drives the gear turntable to rotate.
The panoramic light follow-up device according to claim 2, wherein the panoramic light follow-up device further comprises:

Several distance sensors for sensing the distance between the tested sample and the panoramic light follow-up device;

The control circuit is electrically connected to a plurality of the distance sensors and the stepping motor, and is used to control the stepping motor to drive the gear body to rotate according to the distance sensed by the distance sensor, so that the gear body Drive the gear wheel to rotate until the irradiation range of the N groups of the optical units reaches the target range.
The panoramic light follow-up device according to claim 1, wherein the panoramic light follow-up device further comprises:

N groups of slider units corresponding to the N groups of said optical units one-to-one;

The slider unit includes:

The guide rails are evenly distributed on the side of the fixed plate away from the gear wheel, and are arranged in parallel with the first sliding groove; and

The slider body is slidably arranged on the guide rail;

Wherein, the slider body is connected to the optical unit, and the optical unit realizes a sliding connection with the fixed plate through the slider body and the guide rail.
The panoramic light follow-up device of claim 4, wherein the guide rails are uniformly distributed in a ring shape on a side of the fixed plate away from the gear wheel.
The panoramic light follow-up device according to claim 4, wherein the guide rail is detachably connected to the fixing plate by screws.
The panoramic light follow-up device according to claim 1, wherein the optical unit comprises:

A bracket, one end of the bracket penetrates the first chute and the second chute, so that the gear wheel can drive the optical unit in the first chute and the second chute through the bracket. The two sliding grooves slide synchronously, and the other end of the bracket is a clamping mechanism;

The optical fiber bundle mounting seat is installed in the clamping mechanism of the bracket, wherein the optical fiber bundle mounting seat is provided with a first accommodating cavity and a second accommodating cavity which are penetrated and coaxially arranged with each other, and the first accommodating cavity is used for For fixing the optical fiber sub-bundle;

An optical fiber sub-bundle, one end of the optical fiber sub-bundle is inserted into the first accommodating cavity;

A lens unit, one end of the lens unit is inserted into the second accommodating cavity, wherein the laser light output by the optical fiber sub-bundle can be projected onto the sample under test through the light-transmitting hole of the lens unit to form a light spot.
The panoramic light follow-up device according to claim 7, wherein a V-shaped groove is provided in the optical fiber bundle mounting seat.
The panoramic light follow-up device according to claim 7, wherein:

The lens unit includes: a beam shaping lens and a first housing and a second housing that are connected into one body, and the beam shaping lens includes a convex lens, a first concave lens, and a second concave lens;

The first housing is provided with a boss protruding in a direction away from the second housing, and the boss is used to clamp the optical fiber sub-bundle;

The inner wall of the second housing is formed with three hole sections connected back and forth in sequence. The convex lens, the first concave lens, and the second concave lens are sequentially installed in the three hole sections, and the convex lens, the The centers of the first concave lens and the second concave lens are facing the light-transmitting hole.
The panoramic light follow-up device according to claim 7, wherein:

The angle between the optical axis of the optical fiber bundle mounting seat and the lens unit and the fixing plate is 45 degrees.
The panoramic light follow-up device according to claim 1, wherein:

The panoramic light follow-up device further includes: a limit support bearing, the limit support bearing is used to limit and support the gear turntable;

The limit support bearing includes: a first sub limit support bearing and a second sub limit support bearing fixed on the fixing plate;

The limit support bearing further includes a third sub limit support bearing fixed on the top end of the bracket.
The panoramic light follow-up device according to claim 11, wherein the third sub-limit support bearing is a flange bearing.
The panoramic light follow-up device according to claim 1, wherein:

The vertical distances from the optical units in each group to the fixing plate are the same, and the angles between the optical units in each group and the fixing plate are also the same.
The panoramic light follow-up device according to claim 1, wherein:

The fixing plate is provided with a first through hole, the gear wheel is provided with a second through hole, the first through hole and the second through hole penetrate, the first through hole and the second through hole The through hole is used to sleeve the outer circumference of the sample to be tested.
The panoramic light follow-up device according to claim 14, wherein:

The diameters of the first through hole and the second through hole are both greater than or equal to 20 cm.
A photoacoustic imaging system, which includes:

A nanosecond pulsed laser, an ultrasonic transducer, a high-speed data acquisition board, and the panoramic light follower of any one of claims 1-15, the ultrasonic transducer is arranged below the panoramic light follower ；

The nanosecond pulsed laser is used to output pulsed laser;

The panoramic light follow-up device is used to scan the photoacoustic signal generated by the pulsed laser irradiating the biological tissue;

The ultrasonic transducer is used to receive the photoacoustic signal and convert it into an electrical signal;

The high-speed data acquisition board is used to collect the electrical signal after the signal is amplified, and convert the electrical signal after the signal amplification into a digital signal, and store it in the photoacoustic imaging system.
The photoacoustic imaging system according to claim 16, wherein the photoacoustic imaging system further comprises:

A precision mechanical scanning platform, the optical imaging device and the ultrasonic transducer are fixed on the confidential mechanical scanning platform.
The system according to claim 16, wherein:

The ultrasonic transducer includes two oppositely spliced semi-annular sub-ultrasonic transducers.
The system according to claim 16, wherein:

Several distance sensors of the panoramic light follower are evenly distributed on the super energy transducer.
The system according to claim 19, wherein:

The number of the distance sensors is twelve.