CN204813815U - Hand -held type photoacoustic imaging probe - Google Patents
Hand -held type photoacoustic imaging probe Download PDFInfo
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- CN204813815U CN204813815U CN201520605201.4U CN201520605201U CN204813815U CN 204813815 U CN204813815 U CN 204813815U CN 201520605201 U CN201520605201 U CN 201520605201U CN 204813815 U CN204813815 U CN 204813815U
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Abstract
The utility model provides a hand -held type photoacoustic imaging probe relates to optoacoustic imaging technique field. This probe is including an ultrasonic probe and a light source that is used for launching the exciting light, exciting light coupling in a first optical fiber bundle, the terminal branching of first optical fiber bundle is young the restrainting of first optic fibre to be restrainted with second optic fibre, and the young end of restrainting terminal and that second optic fibre is restrainted of first optic fibre is provided with first cuboid structure and second cuboid structure respectively, be located the ultrasonic probe both sides, and its light -emitting direction is parallel with ultrasonic probe's detection direction, lower extreme at ultrasonic probe is provided with a coupling module, be provided with the smooth reflection configuration who corresponds with first cuboid structure and second cuboid structure respectively in coupling module both sides, the light that jets out from first cuboid structure and second cuboid structure assembles in the coupling module bottom through the reflection of light reflection configuration, the form a rectangle facula. Thereby shine the object that awaits measuring, inspire the optoacoustic signal, finally detected by ultrasonic probe.
Description
Technical field
This utility model relates to technical field of photoacoustic, particularly relates to a kind of hand-held photoacoustic imaging probe.
Background technology
Current, optical image technology has become one of technology with the fastest developing speed in current Medical Imaging Technology because of it in the advantage of certain or the many aspects such as resolution, chemical specificity, sensitivity, safety.But the limitation due to tissue penetration depths limits the development of optical image technology, therefore a kind of photoacoustic imaging technology arises at the historic moment.Photoacoustic imaging has the advantage of optical imagery high-contrast and specificity and acoustics imaging high-resolution and penetration depth simultaneously, because there is absorption in various degree in the biological tissue of different constituent to light, be contrast mechanism thus, chemical constituent and the physiological function information of organism can be obtained.Photoacoustic imaging technology has been proved to be in cancer earlier detection, tumor grades such as being applicable to breast carcinoma and has guided a series of biomedical applications such as SLND, the detection of Ink vessel transfusing vulnerable plaque.Existing photoacoustic imaging system is carry out imaging based on fixed test probe mostly, needs the add-on assemble of supporting complex and expensive, such as, for allowing patient put down sleeping special platform etc. in breast cancer detection simultaneously.Research was had to attempt directly carrying out exciting light coupling on the hand-held probe basis of existing supersonic imaging apparatus in recent years, carry out hand-held real-time optoacoustic cross-sectional imaging, its advantage is the handiness that can make full use of ultrasonic hand-held probe, carry out the photoacoustic imaging of health different parts, gained photoacoustic image can be mated with ultrasonoscopy automatic reclosing in addition, realizes the object of multi-modality imaging.Compare traditional acousto-optic imaging method, this mentality of designing is more easily accepted by clinician, is conducive to the clinical conversion of photoacoustic technique; But the Major Difficulties of this design is, how exciting light is succinctly delivered to target tissue site efficiently, when significantly not increasing ultrasonic probe size, obtains high-quality photoacoustic image, being still a challenge at present.
Current, in the photoacoustic imaging system based on ultrasonic hand-held linear transducer array, the Coupling Design of its optical illumination part and ultrasonic probe mainly contains the following two kinds:
The first design as shown in Figure 1, fibre bundle 1 is coupled into from the exciting light of light source outgoing, the other end (end) of fibre bundle 1 is bound to ultrasonic probe 2 both sides respectively after bifurcated, make exciting light oblique illumination to sample 3 surface, and certain depth converge immediately below ultrasonic probe 2 center.This design is commonly called dark-ground illumination design, its major defect is that optical illumination region and ultrasonic probe search coverage exist mismatch problem, this is because irradiate light to enter tissue from ultrasonic probe 2 both sides, the region of focusing is there is in its illuminated area mainly light in tissue, and in other search coverages of ultrasonic probe 2, exciting light energy is very weak, be difficult to inspire enough strong photoacoustic signal, therefore this excitation light irradiation method makes photoacoustic signal mainly come from the light region that generation focuses in tissue, and other search coverages of ultrasonic probe 2 (as probe near field and far-field region) imaging effect is unsatisfactory.In addition, because this design adopts fibre bundle 1 to carry out irradiating the transmission of light and exciting of sample, make its cost relatively high.
The second design as shown in Figure 2, pop one's head in 2 coupling units matched 4 with ultrasonic hand-held by adding, by excitation light irradiation in sample 3, and the photoacoustic signal that detection simultaneously produces.In this design, equally first the exciting light that light source sends is coupled into single high energy multimode fibre, to expand through space and after cylindrical lens focus from the light of optical fiber connector outgoing, sample 3 is irradiated to inner through acoustic reflection plate ultrasonic signal being played to reflection, the photoacoustic signal produced enters coupling unit 4 through organizing interior transmission, reflected by acoustic reflection plate, received by ultrasonic hand-held probe 2.This design is commonly called bright field illumination design, exciting light can be coupled to the whole surveyed area of ultrasonic probe by it, improve picture quality and the signal to noise ratio of system simultaneously, but its major defect is that its coupling unit is too complicated, make originally small and exquisite ultrasonic probe flexibly 2 become huge, be no longer applicable to the detection of some human body as oxter or hip lower area; In addition, in this design, ultrasonic probe 2 is parallel with sample 3 tissue surface, and is no longer traditional vertical direction, and this also may exist adaptive problem for operator.
The third designs as shown in Figure 3, by adding micro lens group 20, by exciting light and ultrasonic probe 40 co-axial couplings.After the shaping of exciting light scioptics group 20, by twice total reflection of polymethyl methacrylate (being called for short PMMA) material 32, enter organization internal.The photoacoustic signal produced, through lucite, is received by ultrasonic probe.The bright field illumination that this design adopts optoacoustic coaxial, makes picture quality be increased.Its major defect is, exciting light needs Multiple through then out shaping lens group and lucite, has higher energy loss.And micro-shaping lens is difficult to processing, makes its light path precision limited.On the other hand, because photoacoustic signal needs to be received by ultrasonic probe by lucite, have lost signal intensity to a certain extent.And adopt simple optical fiber to carry out exciting light transmission, make the light energy of object greatly limited, and the very high photoacoustic image of signal to noise ratio cannot be obtained.
To sum up analyzing, there is following shortcoming in prior art:
Existing other based in the design of fibre bundle, illumination enters to inject tissue (as shown in Figure 1) from probe both sides, probe detection region is not overlapped with light area, be difficult to the image obtaining high s/n ratio, and superficial tissue is difficult to detect signal.Coaxial and the photoacoustic signal of existing optoacoustic through acoustic mirror by the design (as shown in Figure 2) received of popping one's head in, shortcoming is that ultrasonic probe array becomes huge, and ultrasonic probe with organize parallel, adaptive problem may be there is in this design for operator.In addition, due to will through multiple lens, illumination and photoacoustic signal lose seriously, and jig Design is complicated, and very high to required precision.Existing employing reflects the design (as shown in Figure 3) by incident illumination and ultrasonic probe co-axial couplings based on the shaping of micro lens group and lucite, its shortcoming is mainly the light from simple optical fiber outgoing, after multiple miniature shaping lens and PMMA coupling module, light energy can be lost greatly, makes it be difficult to obtain the photoacoustic image of high s/n ratio.
Visible, the defect how overcome existing for these prior aries is the art problem demanding prompt solution.
Utility model content
Embodiment of the present utility model provides a kind of hand-held photoacoustic imaging to pop one's head in, huge to solve current hand-held photoacoustic imaging probe size, be not easy to operator use, and do not overlap due to probe detection region and light area or the problem being difficult to the image obtaining high s/n ratio that light energy losses reason causes.
For achieving the above object, this utility model adopts following technical scheme:
A hand-held photoacoustic imaging probe, comprise a ultrasonic probe and for launching the light source of exciting light, described exciting light is coupled in one first fibre bundle; The end furcations of described first fibre bundle is the first optical fiber bundle and the second optical fiber bundle, and the end of described first optical fiber bundle and the end of described second optical fiber bundle are respectively arranged with the first rectangular structure and the second rectangular structure; Described first rectangular structure and the second rectangular structure are positioned at described ultrasonic probe both sides, and described first rectangular structure is parallel with the detection direction of described ultrasonic probe with the light direction of the second rectangular structure; The lower end of described ultrasonic probe is provided with a coupling module; The light reflection structure corresponding with described first rectangular structure and the second rectangular structure is respectively arranged with in described coupling module both sides; From described first rectangular structure and the second rectangular structure injection light through described light reflection structure reflecting focal bottom described coupling module, formed rectangular light spot.
Concrete, described coupling module is lucite coupling module, water coincidence module, ultrasonic coupling agent coupling module or agarose coupling module.
In addition, described light reflection structure comprises total reflection prism.
Described light reflection structure also comprises the angle adjusting mechanism be connected with described total reflection prism, and described angle adjusting mechanism drives described total reflection prism, and the angle of the reflecting surface of described total reflection prism is changed.
Or described light reflection structure comprises silver-plated film reflecting mirror.
Described light reflection structure also comprises the angle adjusting mechanism be connected with described silver-plated film reflecting mirror, and described angle adjusting mechanism drives described silver-plated film reflecting mirror, and the angle of the reflecting surface of described silver-plated film reflecting mirror is changed.
In addition, described coupling module and described light reflection structure are shaped on a trapezoidal PMMA material block, and two inclined-planes of described trapezoidal PMMA material block are coated with optical reflection film; From described first rectangular structure and the second rectangular structure injection light through the bottom of described optical reflection film reflecting focal in described PMMA material block, formed rectangular light spot.
A kind of hand-held photoacoustic imaging probe that this utility model embodiment provides, the end furcations of the first fibre bundle is the first optical fiber bundle and the second optical fiber bundle, form Y-shaped, and the first rectangular structure of the end setting of the end of the first optical fiber bundle and described second optical fiber bundle and the second rectangular structure are fixed on ultrasonic probe both sides, and the lower end of ultrasonic probe is provided with a coupling module; Making the light of fibre bundle outgoing after light reflection structure is only once totally reflected, enter coupling module is radiated on the object to be measured of probe below, significantly do not increasing ultrasonic hand-held linear transducer array size, and under the prerequisite that light energy losses is less because of being only once totally reflected, make optical illumination coaxial with acoustic detection, make to be popped one's head in by this hand-held photoacoustic imaging, the image of high s/n ratio can be obtained, and avoid operator to the unconformable situation of operation.
Accompanying drawing explanation
In order to be illustrated more clearly in this utility model embodiment or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the first hand-held photoacoustic imaging probe of the prior art;
Fig. 2 is the structural representation of the second hand-held photoacoustic imaging probe of the prior art;
Fig. 3 is the structural representation of the third hand-held photoacoustic imaging probe of the prior art;
The structural representation one of a kind of hand-held photoacoustic imaging probe that Fig. 4 provides for this utility model embodiment;
The structural representation two of a kind of hand-held photoacoustic imaging probe that Fig. 5 provides for this utility model embodiment;
The structural representation three of a kind of hand-held photoacoustic imaging probe that Fig. 6 provides for this utility model embodiment;
The structural representation four of a kind of hand-held photoacoustic imaging probe that Fig. 7 provides for this utility model embodiment.
Detailed description of the invention
Below in conjunction with the accompanying drawing in this utility model embodiment, be clearly and completely described the technical scheme in this utility model embodiment, obviously, described embodiment is only this utility model part embodiment, instead of whole embodiments.Based on the embodiment in this utility model, those of ordinary skill in the art are not making the every other embodiment obtained under creative work prerequisite, all belong to the scope of this utility model protection.
As shown in Figure 4, this utility model embodiment provides a kind of hand-held photoacoustic imaging to pop one's head in 10, and comprise a ultrasonic probe 101 and for launching the light source 102 of exciting light, the exciting light that this light source 102 sends is coupled in one first fibre bundle 103.The end furcations of this first fibre bundle 103 is the first optical fiber bundle 104 and the second optical fiber bundle 105, and the end of this first optical fiber bundle 104 and the end of the second optical fiber bundle 105 are respectively arranged with the first rectangular structure 106 and the second rectangular structure 107; This first rectangular structure 106 and the second rectangular structure 107 are positioned at ultrasonic probe 101 both sides, and this first rectangular structure 106 is parallel with the detection direction of this ultrasonic probe 101 with the light direction of the second rectangular structure 107, such as, if detection direction is straight down, then this light direction is also straight down; A coupling module 108 is provided with in the lower end of this ultrasonic probe 101.The light reflection structure 109 corresponding with the first rectangular structure 106 and the second rectangular structure 107 is respectively arranged with in these coupling module 108 both sides; From the first rectangular structure 106 and the second rectangular structure 107 injection light through this light reflection structure 109 reflecting focal bottom this coupling module 108, formed rectangular light spot.Like this, this rectangular light spot irradiates object 110 to be measured, inspires photoacoustic signal, and finally this photoacoustic signal is detected by ultrasonic probe.
By the said structure in this utility model embodiment, by the whole search coverage of excitation light irradiation to probe, can not cause a large amount of light and the loss of acoustic energy, can not significantly increase ultrasonic probe size simultaneously, thus be easy to using and operating of operator.
What deserves to be explained is, the coupling module 108 in this utility model embodiment can be lucite coupling module, water coincidence module, ultrasonic coupling agent coupling module or agarose coupling module.Above-mentioned coupling module is higher with object acoustic impedance matching degree to be measured and the material that ultrasonic loss is less.
In addition, this light reflection structure 109 can comprise total reflection prism 111, and in the diagram, this total reflection prism 111 is two quadrant prisms, is arranged at coupling module 108 both sides.
Or as shown in Figure 5, this light reflection structure 109 can comprise silver-plated film reflecting mirror 112.In Figure 5, this silver-plated film reflecting mirror 112 can be arranged at coupling module 108 both sides.
In addition, as shown in Figure 5 and Figure 6, this light reflection structure 109 can also comprise the angle adjusting mechanism 113 be connected with described total reflection prism 111 or silver-plated film reflecting mirror 112, this angle adjusting mechanism 113 can drive total reflection prism 111 or silver-plated film reflecting mirror 112, and the angle of the reflecting surface of the reflecting surface of total reflection prism 111 or silver-plated film reflecting mirror 112 is changed.
By adjusting angle governor motion 113, the angle of the reflecting surface of the reflecting surface of total reflection prism 111 or silver-plated film reflecting mirror 112 is changed, the incident angle of the light changing coupling module can be realized, thus change the Energy distribution of light, realize the object of the different depth of detection object to be measured.
In addition, as shown in Figure 7, this coupling module 108 can be shaped on a trapezoidal PMMA material block 114 with described light reflection structure 109, and two inclined-planes of this trapezoidal PMMA material block 114 are coated with optical reflection film 115.From this first rectangular structure 106 and the second rectangular structure 107 injection light through optical reflection film 115 reflecting focal in the bottom of this PMMA material block 114, formed rectangular light spot.Adopt this integrated mode, succinctly easy, be convenient to the manufacture of coupling module and light reflection structure.
A kind of hand-held photoacoustic imaging probe that this utility model embodiment provides, the end furcations of the first fibre bundle is the first optical fiber bundle and the second optical fiber bundle, form Y-shaped, and the first rectangular structure of the end setting of the end of the first optical fiber bundle and described second optical fiber bundle and the second rectangular structure are fixed on ultrasonic probe both sides, and the lower end of ultrasonic probe is provided with a coupling module; Making the light of fibre bundle outgoing after light reflection structure is only once totally reflected, enter coupling module is radiated on the object to be measured of probe below, significantly do not increasing ultrasonic hand-held linear transducer array size, and under the prerequisite that light energy losses is less because of being only once totally reflected, make optical illumination coaxial with acoustic detection, make to be popped one's head in by this hand-held photoacoustic imaging, the image of high s/n ratio can be obtained, and avoid operator to the unconformable situation of operation.
Apply specific embodiment in this utility model to set forth principle of the present utility model and embodiment, the explanation of above embodiment just understands method of the present utility model and core concept thereof for helping; Meanwhile, for one of ordinary skill in the art, according to thought of the present utility model, all will change in specific embodiments and applications, in sum, this description should not be construed as restriction of the present utility model.
Claims (7)
1. a hand-held photoacoustic imaging probe, it is characterized in that, comprise a ultrasonic probe and for launching the light source of exciting light, described exciting light is coupled in one first fibre bundle; The end furcations of described first fibre bundle is the first optical fiber bundle and the second optical fiber bundle, and the end of described first optical fiber bundle and the end of described second optical fiber bundle are respectively arranged with the first rectangular structure and the second rectangular structure; Described first rectangular structure and the second rectangular structure are positioned at described ultrasonic probe both sides, and described first rectangular structure is parallel with the detection direction of described ultrasonic probe with the light direction of the second rectangular structure; The lower end of described ultrasonic probe is provided with a coupling module; The light reflection structure corresponding with described first rectangular structure and the second rectangular structure is respectively arranged with in described coupling module both sides; From described first rectangular structure and the second rectangular structure injection light through described light reflection structure reflecting focal bottom described coupling module, formed rectangular light spot.
2. hand-held photoacoustic imaging probe according to claim 1, it is characterized in that, described coupling module is lucite coupling module, water coincidence module, ultrasonic coupling agent coupling module or agarose coupling module.
3. hand-held photoacoustic imaging probe according to claim 1, it is characterized in that, described light reflection structure comprises total reflection prism.
4. hand-held photoacoustic imaging probe according to claim 3, it is characterized in that, described light reflection structure also comprises the angle adjusting mechanism be connected with described total reflection prism, described angle adjusting mechanism drives described total reflection prism, and the angle of the reflecting surface of described total reflection prism is changed.
5. hand-held photoacoustic imaging probe according to claim 1, it is characterized in that, described light reflection structure comprises silver-plated film reflecting mirror.
6. hand-held photoacoustic imaging probe according to claim 5, it is characterized in that, described light reflection structure also comprises the angle adjusting mechanism be connected with described silver-plated film reflecting mirror, described angle adjusting mechanism drives described silver-plated film reflecting mirror, and the angle of the reflecting surface of described silver-plated film reflecting mirror is changed.
7. hand-held photoacoustic imaging probe according to claim 1, it is characterized in that, described coupling module and described light reflection structure are shaped on a trapezoidal PMMA material block, and two inclined-planes of described trapezoidal PMMA material block are coated with optical reflection film; From described first rectangular structure and the second rectangular structure injection light through the bottom of described optical reflection film reflecting focal in described PMMA material block, formed rectangular light spot.
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| CN201520605201.4U CN204813815U (en) | 2015-08-12 | 2015-08-12 | Hand -held type photoacoustic imaging probe |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105167747A (en) * | 2015-08-12 | 2015-12-23 | 中国科学院深圳先进技术研究院 | Handheld photoacoustic imaging probe |
| CN107174208A (en) * | 2017-05-24 | 2017-09-19 | 哈尔滨工业大学（威海） | A kind of photoacoustic imaging system and method suitable for peripheral vascular imaging |
| CN112304868A (en) * | 2019-07-24 | 2021-02-02 | 上海科技大学 | Portable photoacoustic imaging device, zooming and beam expanding device and photoacoustic imaging test system |
| WO2022027863A1 (en) * | 2020-08-07 | 2022-02-10 | 中国科学院深圳先进技术研究院 | Polarization-based photoacoustic imaging probe and photoacoustic imaging apparatus |
| WO2022141108A1 (en) * | 2020-12-29 | 2022-07-07 | 深圳迈瑞生物医疗电子股份有限公司 | Photoacoustic imaging probe and photoacoustic imaging system |
-
2015
- 2015-08-12 CN CN201520605201.4U patent/CN204813815U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105167747A (en) * | 2015-08-12 | 2015-12-23 | 中国科学院深圳先进技术研究院 | Handheld photoacoustic imaging probe |
| CN105167747B (en) * | 2015-08-12 | 2018-03-23 | 中国科学院深圳先进技术研究院 | A kind of hand-held photoacoustic imaging probe |
| CN107174208A (en) * | 2017-05-24 | 2017-09-19 | 哈尔滨工业大学（威海） | A kind of photoacoustic imaging system and method suitable for peripheral vascular imaging |
| CN112304868A (en) * | 2019-07-24 | 2021-02-02 | 上海科技大学 | Portable photoacoustic imaging device, zooming and beam expanding device and photoacoustic imaging test system |
| WO2022027863A1 (en) * | 2020-08-07 | 2022-02-10 | 中国科学院深圳先进技术研究院 | Polarization-based photoacoustic imaging probe and photoacoustic imaging apparatus |
| WO2022141108A1 (en) * | 2020-12-29 | 2022-07-07 | 深圳迈瑞生物医疗电子股份有限公司 | Photoacoustic imaging probe and photoacoustic imaging system |
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