CN106798656A - A kind of depth hair conditioner comprising Yak Bone small-molecular peptides and preparation method thereof - Google Patents

Abstract

A kind of depth hair conditioner comprising Yak Bone small-molecular peptides, it is characterised in that its formula is consisted of the following composition：Surfactant 15.0 30.0%, Yak Bone small-molecular peptides 1.0 15.0%, thickener 0.01 2.0%, preservative 0.01 0.5%, NMF 0.05 2.0%, plant extracts 1.0 20.0%, essence 0.1 3.0%, remaining is deionized water.Also disclose its preparation method.The hair conditioner can effectively nourish root of hair due to using Yak Bone small-molecular peptides, repair impaired hair quality albumen, can also give hair a kind of salubriouser nursing impression.

Description

A kind of depth hair conditioner comprising Yak Bone small-molecular peptides and preparation method thereof

Technical field

It is more particularly to a kind of comprising the depth hair conditioner of Yak Bone small-molecular peptides and its preparation the present invention relates to household chemicals field Method.

Background technology

Hair conditioner (hair conditioner) is people's hair products used in everyday, mainly by surfactant, cosurfactant Agent, fatting agent, preservative, pigment, essence and other active components composition, are divided into transparent type and emulsion-type two from mode of appearance Kind.After cleaning hair with shampoo, hair conditioner is reused, it can neutralize and remain in molecule of the hair surface with anion, shape Into monomolecular film, and obey the hair of entanglement, it is easy to combing.

The small-molecule substance of shield raw material mostly chemical synthesis or plant extract is washed including the traditional function including hair conditioner, And it is near during the last ten years substantially to biological polyoses and protein and peptide class physical development.During the metabolic cycles of cell, rise certainly What is be set for is mostly protein or polypeptide, including some special enzymes and the cell factor that plays regulatory role.People are from natural Extracted in material or designed in bionical method and synthesize some active materials (peptides or protein), be used to participate in cell Composition provides brand-new side with metabolism, the biochemical reactions in regulating cell to wash shield product development of raw materials and finished article design To and thinking, at home and abroad the various applications washed in shield product are also more and more universal.

CN103191033 A disclose a kind of shampoo composite of cationic starch, comprising following weight percentage Raw material：A.8-40% surfactant；B.0.1-5% cationic starch；C.0.1-10% silicone oil emulsion；D. it is balance of Water；The surfactant is selected from one or more in anion surfactant or amphoteric surfactant；The silicone oil The particle diameter of emulsion is 1nm-10 μm；The cationic starch is by starch and 2.3- epoxypropyltrimethylchloride chlorides, the chloro- 2- hydroxyls of 3- Hydroxypropyltrimonium chloride or the chloro- 2- hydroxypropyl dimethyls-lauryl ammonium chlorides of 3- are prepared.

CN103462844 A disclose a kind of Haircare composition containing efficient anticreep complexing agent, the Haircare composition except Include outside long-chain alcohol, cationic surfactant, thickener, essence, preservative, chelating agent, water, also comprising accounting for composition weight The anticreep composite reactive thing of amount 0.1% to 10%, its anticreep composite reactive thing is hydrolytic soya bean protein, amino acid, amino sugar, dimension Give birth to the composition of element B groups, zinc salt, ginseng essence, May radix bardanae essence and organosilicon and polyquaternium.

CN104127327 A disclose a kind of hair products containing marine protein peptide, contain seashells activity Peptide, it is possible to be further aided with deep-sea small-micelle water and ginger-root extract, can also further contain olive oil and elastic egg In vain, or also hydrolysis of keratin and panthenol are contained.

CN104784074A discloses a kind of cation nanometer emulsion with antiallergic effect, its by 10%~30% plant Thing antiallergic compound, 3%~30% glycerine, 5%~30% caprylic/capric triglyceride, 0.1%~3% cholesterol, 2% ~25% glycolipid, 0.1%~2% polyquaternium -51,0.05%~0.3% methyl hydroxybenzoate and excess water composition；The plant Antiallergic compound is extracted by 15%~30% Olive leaf P.E, 5%~10% gorgonian extract, 10%~20% sugared sea-tangle Thing, 3%~5% kawakaw extract and surplus octyl dodecanol composition.

CN104958194 A disclose kind of the hair conditioner and preparation method that contain linseed extract solution.It is described to be carried containing linseed Take the hair conditioner of liquid, by linseed extract solution, primary surfactant, cosurfactant, cation opsonizing agent, fatting agent, NMF, thickener, chelating agent and preservative composition.Its preparation method be successively by chelating agent, thickener, NMF, sun from Sub- conditioner is added in linseed extract solution, and 75-85 DEG C is heated to after mixing as A phases；By primary surfactant, supplementary table Face activating agent, fatting agent are heated to 75-85 DEG C as B phases after mixing；Homogeneous after 85 DEG C of constant temperature A phases of water-bath, gained B is added to A phases continue emulsifying and obtain emulsion；Then 40-45 DEG C of addition preservative is cooled to, is cooled to room temperature and is obtained final product with nourishing, protects Wet, hair care conditioning effect the hair conditioner containing linseed natural botanical extraction liquid.

CN105431154 A disclose a kind of local antibacterial composition and its application method, the local antibacterial composition that it is related to, Comprising n-trimethyl chitosan chloride derivative, wherein containing polymerizable organic moiety and amphoteric surfactant.

A kind of natural hair conditioners of CN1362056A, are mainly formulated by natural plant sap and mineral water.

A kind of hair growing conditioners of CN1089133A, be with Chinese herbal medicine cacumen biotae, ginkgo leaf, cattail pollen alcohol extract as homophony System is formed.

US2015118320A1 discloses aqueous dispersions, and it is included：(A) have 0.3~20 μm of volume-cumulative 90% straight The mass % of silicone rubber particles 5~80 in footpath (D90)；(B) HLB value be 12.8~15.1 and the alkyl with carbon number 18 it is poly- At least a kind 0.01~15 mass % in oxygen vinyl alkyl ether；And the mass % of (C) water 19~94.

" ox bone I-type collagen is extracted and structural characterization ", Liu Lili etc., Food Science, volume 2010,31 the 2nd phase, pin To the technique of ox bone collagen protein extraction, (degreasing, decalcification, Extraction medium and structural characterization are studied.Result shows：Optimal Extracting factor：Using ether low temperature reflux degreasing, 0.48% hydrochloric acid decalcification, skeletal grain footpath is 5ram × 10ram, with 1% lemon Lemon acid and 1% pepsin are complex as Extraction medium.However, the collagen middle-molecular-weihydroxyethyl that the method is extracted is less than 1000 dongles The small peptide mass fraction for pausing is relatively low, and fatty impurity content is higher only in 30-40%, and collagen, if so as to cause For hair conditioner, nourishes effect is poor, and the presence of impurity can cause the undesirable result for example to cause hair quality oil etc. partially.

Prior art has no the hair conditioner for making major ingredient using small-molecular peptides active material, especially has no and utilizes from Yak Bone The small-molecular peptides active material of extraction makees the hair conditioner of major ingredient, also has no how to extract acquisition molecular weight less than 1000 dalton The report of small-molecular peptides.

The content of the invention

It is an object of the invention to provide a kind of hair conditioner (hair conditioner) comprising Yak Bone small-molecular peptides and its preparation side Method, the hair conditioner has good hairy root nourishing to hair, repairs the effect of nutrition.Hair conditioner obtained by this method safely may be used By, have no toxic side effect, in product not only with the addition of with nourish hair cell Yak Bone small-molecular peptides, be not likely to produce greasy Sense, also added the plant essences such as ginseng root extract, dendrobium candidum in addition, and the taste of product is elegant, and quality is fine and smooth, is allowed to raw Hair, black hair, the effect of hair care are greatly improved.

To reach above-mentioned technical purpose, this invention takes following technical scheme：It is a kind of comprising Yak Bone small-molecular peptides Depth hair conditioner, its formula includes following component：By weight percentage, surfactant 15.0-30.0%, small point of Yak Bone Sub- peptide 1.0-15.0%, thickener 0.01-2.0%, preservative 0.01-0.5%, NMF 0.05-2.0%, plant extracts 1.0-20.0%, essence 0.1-3.0%, remaining is deionized water.

The inventors discovered that, Yak Bone collagen is a large amount of small point by that can be produced after the method treatment such as specific enzymolysis Sub- peptide (small peptide), small peptide is formed by Raw material processing of Yak Bone collagen, and it is that a kind of molecular weight is smaller than collagen Many peptides, its middle-molecular-weihydroxyethyl is 85% or so, these bone glue of yak less than the small peptide mass fraction below 1000 dalton Former protein small peptide is soluble in water, is more easy to quickly be absorbed by human body, without digesting can go directly human cell tissue, the day prepared with it Changing product has functions that depth trophocyte, repairs damaged cell and delaying cell aging.

Preferably, the hair conditioner composition includes by weight：Surfactant 8.0-30.0%, Yak Bone small-molecular peptides 6.0-15.0%, thickener 0.01-2.0%, preservative 0.01-0.5%, NMF 0.05-2.0%, plant extracts 1.0- 20.0%th, the deionized water of essence 0.1-3.0% and surplus.

Preferably, the hair conditioner composition includes by weight：Surfactant 6.0-20.0%, Yak Bone small-molecular peptides 6.0-10.0%, thickener 0.1-2.0%, preservative 0.1-0.5%, NMF 0.5-2.0%, plant extracts 4.0- 14.0%th, the deionized water of essence 0.5-3.0% and surplus.

Preferably, the hair conditioner composition includes by weight：Surfactant 15.0-25.0%, Yak Bone small molecule Peptide 1.0-6.0%, thickener 0.5-2.0%, preservative 0.2-0.5%, NMF 0.5-2.0%, plant extracts 5.0- 20.0%th, the deionized water of essence 0.5-2.0% and surplus.

Preferably, the hair conditioner composition includes by weight：Surfactant 16.0%, Yak Bone small-molecular peptides 12.0%th, thickener 2.0%, preservative 0.4%, NMF 1.0%, plant extracts 12.0%, essence 1.5% and surplus Deionized water.

The surfactant can be selected from stearyl trimethyl ammonium chloride, PEG-20 stearates, laruyl alcohol polyoxy second Any two or more combination in alkene ether sodium sulfate, laureth -23, portfolio ratio is not limited.

It is particularly preferred that the surfactant can also be the quaternary ammonium salt cationic surfactant shown in lower formula (I)：

R1 and R2 are independently of one another the aliphatic radical with 12-26 carbon atom and 1 or 2 double bond.Research discovery, formula (I) surfactant shown in can provide especially good stability and color protection for hair, particularly colored hair, and The quaternary ammonium salt has excellent biodegradable, can be to hair conditioner of the invention with extraordinary soft feel.

The thickener can be one or more in hydroxyethyl cellulose, cetostearyl alcohol analog copolymer.

The preservative can be Polyquaternium-10, methylchloroisothiazandnone, methylisothiazolinone in one kind or It is several.

The NMF can be dimethiconol, butanediol NMF.

The essence can be one or more in lavender oil, flavoring rose essence, Mint Essence etc..

The plant extracts can be one or more in dendrobium candidum extract, ginseng extract.

In another aspect of this invention, there is provided the preparation side of the above-mentioned depth hair conditioner comprising Yak Bone small-molecular peptides Method, the method is comprised the following steps：

(1) water in formula is weighed, is heated to adding surfactant under 90-95 DEG C, stirring condition, stirring is to completely molten Solution；

(2) Yak Bone small-molecular peptides, plant extracts, preservative, thickener, NMF, essence are sequentially added；

(3) after stirring, the pH value for being adjusted to shampoo with pH adjusting agent is 6.0-7.0, is aged 20 hours, that is, obtain this The Yak Bone small-molecular peptides depth hair conditioner of invention.

The Yak Bone small-molecular peptides particularly relate to small point of molecular weight less than 1000 dalton extracted from Yak Bone Sub- peptide.

In another aspect of this invention, there is provided extract the side that above-mentioned small-molecular peptides are Yak Bone small-molecular peptides from Yak Bone Method, the method includes degreasing, decalcification and step etc. purification process, more specifically or it is highly preferred that the method is comprised the following steps：

(1) meat of surface attachment, muscle, film, the Yak Bone of cartilage will be rejected to dry, will then be crushed, cross 30 mesh sieves, obtain yak Bovine bone powder；

(2) the degreaser A of its 5-10 times of weight is incorporated as according to yak bone powder weight, degreaser A is chloroform: methyl alcohol: Acetone=(2.0-3.0): (3.0-6.0): (0.5-1.0), the preferably mixture of 1: 2: 0.8 volume ratio, then stir at 0-4 DEG C Degreasing 16-48h is mixed, degreaser A is then filtered off, yak bone powder is added to the ethanol containing surfactant：Water mixed liquid During (preferably 1: 1 volume ratio) is degreaser B, the concentration of surfactant described in degreaser B is 0.01-0.1mol/L, in 5- Degreasing 4-10h is stirred at 10 DEG C；

(3) after the completion of step (2), degreaser B is filtered out, it is 10-15 times of weight of yak bone powder to be subsequently adding The hydrochloric acid solution of 0.1mol/L, the hydrochloric acid solution contains 0.2-0.5mol/L EDTA, 16-32h is stirred at 5-10 DEG C, except desalting Acid solution (such as by centrifugation), the 4mol/L Moroxydine Hydrochlorides of 10-15ml is added according to every g Yak Bones, in 5-10 DEG C Stirring 8-24h, centrifugation, precipitation is fully washed with Tris-HCl (pH7.4) buffer solutions and 0.5-1.0moL/L acetic acid solutions Afterwards, with every g Yak Bones add 5-20ml pepsin digestion liquid and 1-10ml neutral proteinase digestive juices mixed liquor (preferably Comprising 0.5moL/L acetic acid) it is suspended, 12-36h is stirred at 2-4 DEG C, supernatant is collected in centrifugation；

(4) it is for about 7.5 the supernatant to be adjusted to pH with 3.0-5.0mol/LNaOH, adds NaCl to make its concentration be 2.0mol/L, 4 DEG C are saltoutd overnight, and centrifugation obtains supernatant Q1 and precipitation P1；Supernatant Q1 continuously adds NaCl and adjusts NaCl concentration Saltoutd overnight to 4.0mol/L.4 DEG C, centrifugation obtains supernatant Q2 and precipitation P2；Precipitation P1 and P2 is merged, 0.1- is then used 0.3moL/L acetic acids, then pH7.5 is neutralized to 1.0-2.0moL/L NaOH, then with 0.005moL/L Tris-HCl (pH 7.4) after, distilled water carries out dialysis equilibrium, small-molecular peptides first extract E1 is obtained final product；

(5) after Tris-HCl (pH 7.4) buffer solution of small-molecular peptides first extract E1 and 3 times of volumes is mixed, it is placed in beaker In, at the beginning of adding the anionite (preferred anionic exchanger resin) after being balanced with the cushioning liquid, resin and small-molecular peptides The volume ratio of extract E1 is about 1: 5-1: 10, it is well mixed, and after being slowly stirred 60-120min, supernatant is collected in centrifugation； Sodium chloride is added in supernatant makes sodium chloride concentration for 2.0mol/L, and 4 DEG C are saltoutd overnight, and 30min is centrifuged, and collect precipitation, will Precipitation 0.1-0.3moL/L acetic acids, then use 0.05mol/L acetic acid, 0.01mol/L acetic acid, distilled water successively again respectively After carrying out dialysis equilibrium, small-molecular peptides solution is obtained, freeze-drying obtains small-molecular peptides protein freeze-dried powder.

The small-molecular peptides protein freeze-dried powder middle-molecular-weihydroxyethyl is 95 weights less than the ratio of the small-molecular peptides of 1000 dalton Amount more than %, more preferably preferably more than 98 weight %, more than 99 weight %, are more preferably almost small-molecular peptides egg.

For the present invention, as is generally understood, the acetic acid solution and hydrochloric acid solution etc. are Refer to the aqueous solution.

Surfactant in step (2) is preferably amphoteric ionic surfactant.More preferably descend shown in formula (II) Betaine type amphoteric ion：

By the use of the specific surfactant, the fat content in collagen can be made to be reduced to 0.001% weight Amount is following, below preferably 0.0001% weight.The surfactant has many at aspects such as critical micelle concentration, interfacial properties Unique property, such as surface-active, the rheological property of lower Krafft temperature, more preferable dissolubility and uniqueness higher, Therefore taken off to extremely low aspect with especially good effect by fat content, so as to the greasy feeling of hair conditioner is down into relatively low water It is flat.

In addition, by adding acetone solvent in degreaser A, while degreasing effect is improve, additionally it is possible to effectively anti- Only albuminous degeneration, so as to effectively prevent from being denatured the generation of impurity.This was not all reported in former document.

In small-molecular peptides by the inventive method acquisition, molecular weight is for about less than the small peptide mass fraction of 1000 dalton 85%, preferably more than 85%, more preferably more than 90%.

The beneficial effects of the present invention are：The raw material sources of hair conditioner extensively, preparation process is simple, containing small point of Yak Bone Sub- peptide and natural plant composition, low-molecular-weight small peptide ratio are high, and nourishes effect is good, and impurity content is low, and especially ester content is low, Without greasy feeling, texture is submissive, and product safety is non-stimulated, uses back luminance, and dry, wet cardability is fine, with obvious taste The effect of hair is supported, while product has herbaceous plant fragrance, clearly refreshes oneself.

Specific embodiment

With reference to embodiment and comparative example, the present invention will be further described：

Embodiment 1-4

Embodiment 1-4 is the embodiment of Yak Bone small-molecular peptides depth hair conditioner.In the embodiment comprising Yak Bone The formula of the depth hair conditioner of small-molecular peptides see the table below shown in 1：

Table 1：Formula table (based on weight/mass percentage composition)

The hair ox bone small-molecular peptides are the small-molecular peptides extracted from Yak Bone according to preceding method of the present invention, wherein dividing Son amount is 98.5 weight % less than the ratio of the small-molecular peptides of 1000 dalton.

The method for preparing above-described embodiment 1-4 hair conditioners is：The deionized water in formula is weighed, 90 DEG C, stirring are heated to Under the conditions of add surfactant, stirring is to being completely dissolved；Sequentially add Yak Bone small-molecular peptides, plant extracts, anti-corrosion Agent, thickener, NMF, essence；After stirring, the pH value for being adjusted to shampoo with pH adjusting agent is for about 6.5, and ageing 20 is small When.

Comparative example 1

Yak Bone small-molecular peptides are replaced with common bone peptide (purchased from state by the comparative example 1 with differing only in for embodiment 1 Chemical reagent Co., Ltd of medicine group).

Using showing, active ingredient can be made to penetrate into inside hair, and small-molecular peptides can be helped the hair conditioner of embodiment 1-4 Help and repair impaired hair quality albumen, the cuticula that isolation has come off, so as to help repair hair quality surface, protects hair not injured Evil, it can in addition contain experience to a kind of salubriouser nursing of hair, will not feel that hair is heavy.Compareed with this formation, The hair conditioner hair quality repair ability of comparative example 1 is poor, and user has greasy feeling, feels that hair is heavy, without relaxation.

This written description discloses the present invention, including optimal mode using example, and also enables those skilled in the art Manufacture and use the present invention.It is of the invention can patentable scope be defined by the claims, and this area skill can be included Other examples that art personnel expect.If this other examples have the structural elements of literal language not different from claims Element, or if this other examples include equivalent structure element of the literal language without substantial differences with claims, Then this other examples are intended within the scope of claims.In the case where inconsistent degree is not resulted in, by reference to The all references part of reference herein is incorporated herein.

Claims (10)

1. a kind of depth hair conditioner comprising Yak Bone small-molecular peptides, it is characterised in that：Its formula is consisted of the following composition：Surface Activating agent 15.0-30.0%, Yak Bone small-molecular peptides 1.0-15.0%, thickener 0.01-2.0%, preservative 0.01-0.5%, NMF 0.05-2.0%, plant extracts 1.0-20.0%, essence 0.1-3.0%, remaining is deionized water.

2. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1, it is characterised in that：Its composition is by weight Amount ratio includes：Surfactant 6.0-20.0%, Yak Bone small-molecular peptides 6.0-10.0%, thickener 0.1-2.0%, preservative The water of 0.1-0.5%, NMF 0.5-2.0%, plant extracts 4.0-14.0%, essence 0.5-3.0% and surplus.

3. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1 and 2, it is characterised in that：The table Face activating agent is selected from stearyl trimethyl ammonium chloride, PEG-20 stearates, ethoxylated dodecyl alcohol sodium sulphate, laruyl alcohol and gathers Any two or more combination in ether -23, portfolio ratio is not limited.

4. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1 and 2, it is characterised in that：The increasing Thick dose is one or more in hydroxyethyl cellulose, cetostearyl alcohol analog copolymer.

5. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1 and 2, it is characterised in that：It is described anti- Rotten agent is one or more in Polyquaternium-10, methylchloroisothiazandnone, methylisothiazolinone.

6. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1 and 2, it is characterised in that：The guarantor Humectant is dimethiconol, butanediol NMF.

7. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1 and 2, it is characterised in that：The perfume (or spice) Essence is one or more in lavender oil, flavoring rose essence, Mint Essence etc..

8. the depth hair conditioner comprising Yak Bone small-molecular peptides according to claim 1 and 2, it is characterised in that：The plant Thing extract is one or more in dendrobium candidum extract, ginseng extract.

9. a kind of method for preparing the depth hair conditioner comprising Yak Bone small-molecular peptides described in any one of preceding claims, it is special Levy and be：Comprise the following steps：

(1) deionized water in formula is weighed, is heated to adding surfactant under 90-95 DEG C, stirring condition, stirring is to complete Dissolving；

(2) Yak Bone small-molecular peptides, plant extracts, preservative, thickener, NMF, essence are sequentially added；

(3) after stirring, the pH value for being adjusted to shampoo with pH adjusting agent is 6.0-7.0, is aged 20 hours.

10. a kind of method that Yak Bone small-molecular peptides are extracted from Yak Bone, the method walks including degreasing, decalcification and purification process etc. Suddenly.