CN108208021A - Biological bactericide and its purposes in daily chemical product - Google Patents
Biological bactericide and its purposes in daily chemical product Download PDFInfo
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- CN108208021A CN108208021A CN201810175629.8A CN201810175629A CN108208021A CN 108208021 A CN108208021 A CN 108208021A CN 201810175629 A CN201810175629 A CN 201810175629A CN 108208021 A CN108208021 A CN 108208021A
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- extract
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- fleece
- black ganoderma
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- 230000036039 immunity Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000001662 opsonic effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Botany (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
A kind of purposes the invention discloses biological bactericide and its in daily chemical product.The biological bactericide is gadol extract and Black Ganoderma extract (1 10) in mass ratio：(1 10) mix.The biological bactericide of the present invention, sterilizing power is strong, and lasting effect is strong, the suppression of biology is killed with obvious effects more stronger than the exclusive use of each fungicide.The invention also discloses purposes of the above-mentioned biological bactericide in daily chemical product, can specifically prepare shampoo, hair conditioner, liquid detergent, shower cream, hair gel, skin care face cream etc..
Description
Technical field
A kind of purposes the present invention relates to biological bactericide and its in daily chemical product.
Background technology
Fungicide is also known as biocide, Biocidal algae-killing agent, microbicide etc., typically refers to efficiently control or kill water
The chemicals of microorganism in system --- bacterium, fungi and algae.In the world, it is micro- typically as all kinds of cause of diseases are prevented
The general name of the medicament of biology.
In daily chemical product, the research of biological bactericide is a beneficial research direction always.
Invention content
The first technical problem to be solved by the present invention is to provide a kind of biological bactericide.Technology to be solved by this invention
The two of problem are to provide purposes of the above-mentioned biological bactericide in daily chemical product.
A kind of biological bactericide is gadol extract and/or Black Ganoderma extract.
A kind of biological bactericide is gadol extract and Black Ganoderma extract (1-10) in mass ratio：(1-10) mix and
Into.Preferably, gadol extract and Black Ganoderma extract are (1-3) in mass ratio：(1-3), optimal is 1：1.
Gadol extract and Black Ganoderma extract mix to the biological bactericide that can be prepared by the present invention, when use adds
In being formulated to daily chemical product；It can also be respectively by gadol extract and the addition of Black Ganoderma extract in daily chemical product.
Rhodiola root (scientific name：Rhodiola rosea L.), alias：Rhodiola rosea sweeps sieve agate boolean (hiding name) etc.；For
Herbaceos perennial, it is 10-20 centimetres high.The high and cold contamination-freely band of 1800-2500 meters of height above sea level is grown in, growth environment is disliked
It is bad, thus with very strong vitality and special adaptability.Can make it is medicinal, can tonifying Qi clearing lung-heat, intelligence development nourishing heart is to make simply
With extensive Chinese medicine.Also there is very big cosmetic result, skin care item can be made, also edible.
Black Ganoderma (Ganoderma atrum) is referred to as the superfine product in ganoderma lucidum, has medicinal curative effect to body-care, can increase
Strong body's immunity, long-term consumption can adjust internal a variety of functions, and fructification is smaller, suberin.Bacteria cover diameter 2~
6.5cm, 0.8~2cm of thickness, semicircle or subcircular is flat or have near ungulate, surface black or dark red black, it is matt or
Sample gloss is slightly painted, has concentric circular groove or unobvious or has slight vertical wrinkle.
Preferably,
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and adds in 50- after drying
80wt% alcohol refluxs extract 1-3 times, and extraction time 65-85min, each Extracting temperature is 40-60 DEG C, every time during extraction
The rate of charge of rhodiola root raw material and ethyl alcohol is 1：(5-12) (g/ml) is filtered after the completion of extraction, is then combined with extracting solution, and decompression is dense
It is dried after contracting to constant weight, obtains gadol extract.
The preparation method of the Black Ganoderma extract includes the following steps：
I, is dried after Black Ganoderma fructification is sliced, and is then crushed to 30-60 mesh, is obtained Black Ganoderma powder；
II, adds in the extractant of 6-14 times of quality into above-mentioned Black Ganoderma powder, and 1-3h is extracted at 90-98 DEG C, filtering
Filtrate is collected, filter residue extracts again with condition, merges filtrate twice, obtains Black Ganoderma extracting solution；
Above-mentioned Black Ganoderma extracting solution is dried 2-10h by III, obtains the Black Ganoderma extract.
In the preparation method of the Black Ganoderma extract, the extractant is one or more in ethyl alcohol, ammonium hydroxide or water；
The drying mode of the Black Ganoderma extracting solution is one or more in heated-air drying, freeze-drying and vacuum drying.
The biological bactericide of the present invention, sterilizing power is strong, and lasting effect is strong, the suppression of biology is killed with obvious effects than each fungicide list
Solely using stronger.
The present invention also provides purposes of the above-mentioned biological bactericide in daily chemical product, can specifically prepare shampoo, shield
Send out element, liquid detergent, shower cream, hair gel, skin care face cream etc..
Preferably, the shampoo includes the raw material of following mass component：Water, laureth sulfuric ester ammonium, laruyl alcohol
Sulfuric ester ammonium, sodium lauroyl sarcosine, Cocoamidopropyl betaine, glycol distearate, melon glue hydroxypropyl trimethylammonium
Ammonium chloride, sodium chloride, hydrolyzed wheat protein, essence, panthenol, cetostearyl alcohol, citric acid, EDETATE SODIUM, methyl hydroxybenzoate, first
Base isothiazolinone, hair anticreep agent.
Preferably, the shampoo includes the raw material of following mass component：Water, laureth sulfuric ester ammonium, laruyl alcohol
Sulfuric ester ammonium, sodium lauroyl sarcosine, Cocoamidopropyl betaine, glycol distearate, melon glue hydroxypropyl trimethylammonium
Ammonium chloride, sodium chloride, hydrolyzed wheat protein, essence, panthenol, cetostearyl alcohol, citric acid, EDETATE SODIUM, methyl hydroxybenzoate, first
Base isothiazolinone, the agent of hair anticreep, biological bactericide.
Specifically, the shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 4-
10wt%, bay alcohol sulfuric ester ammonium 4-10wt%, sodium lauroyl sarcosine 1-4wt%, Cocoamidopropyl betaine 0.5-
2.5wt%, glycol distearate 0.4-2wt%, guar hydroxypropyltrimonium chloride 0.5-1.5wt%, sodium chloride
0.3-1.2wt%, hydrolyzed wheat protein 0.2-0.8wt%, essence 0.2-0.6wt%, panthenol 0.2-0.4wt%, cetearyl alcohol
Alcohol 0.2-0.4wt%, citric acid 0.05-0.25wt%, EDETATE SODIUM 0.02-0.18wt%, methyl hydroxybenzoate 0.05-
0.12wt%, methylisothiazolinone 0.005-0.01wt%, hair anticreep agent 1-5wt%, biological bactericide 0.5-
1.5wt%, surplus are water.
The hair anticreep agent is Cacumen Platycladi extract, fleece-flower root root extract, one kind in Fructus Viticis extract or more
Kind.
Fructus viticis, Chinese medicine name.Alias：Wild pepper reality, Jing Zi, FRUCTUS VITICIS, turnip, wild pepper, white back fungus, small sword bean rattan,
White leeward, white back of the body grass.Source is Verbenaceae Vitex rotundifolia or the dry mature fruit of wild pepper.Main product in Shandong, Jiangxi,
The provinces such as Zhejiang, Fujian.Acrid flavour, hardship, cold nature.Return lung, bladder, Liver Channel.Its primary efficacy is dispelling wind and heat from the body, and head clearing removes
Wet place joint.It is usually used in exogenous headache, polarization intermittent headache, the mesh that swoons is dark, many tear of red eyes, and pain, gingivitis, arthritis with fixed pain caused by dampness are arrested in mesh eyeball
Contraction.
The Cacumen Platycladi extract is prepared by the following method to obtain：Arbor-vitae leaf raw material is taken, cleans and is added to the water after drying
It decocts 2-4 times, each decocting time is 45-160min, and the quality of each decoction plus water is 8-10 times of arbor-vitae leaf raw material, then
By being concentrated under reduced pressure, being dried to obtain Cacumen Platycladi extract.
The fleece-flower root root extract why Polygonum Multiflorum root impalpable powder and/or fleece-flower root root enzymatic hydrolyzed extract.
The preparation process of the fleece-flower root root impalpable powder is：After fleece-flower root root is taken to clean, 20-40 mesh is crushed to, is then put
It is superfine to obtain the fleece-flower root root that Average Particle Diameters are 8-14 μm by the ultramicro grinding 20-70min under conditions of subzero 5-20 DEG C
Powder.
The preparation method of the fleece-flower root root enzymatic hydrolyzed extract includes the following steps：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 1-4 times of quality is added in into fleece-flower root root powder,
10-20min is stirred with 150-350r/min rotating speeds at a temperature of 25-35 DEG C, obtains fleece-flower root root powder suspension；
The above-mentioned fleece-flower root root powder suspension homogeneous 4-9min, homogenization pressure 100-110MPa are obtained the fleece-flower root by II,
Mixed liquor then adds in the complex enzyme agent of 0.2-0.5% fleece-flower root root mixed liquor quality in the fleece-flower root mixed liquor after homogeneous,
It is 1 in mass ratio by neutral proteinase and cellulase that wherein complex enzyme agent, which is,：(1-3) is mixed, then with a concentration of
0.5mo1/L acetums adjust pH to 4.0-5.0, are then placed into drying box the sealing enzymolysis 60- at 35-45 DEG C
80min obtains enzymolysis liquid；
Above-mentioned enzymolysis liquid is separated by filtration by III, is removed filter residue, is carried out under conditions of then acquired solution is placed in 20-30 DEG C
Ultrafiltration collects filtrate, obtains the filtrate after ultrafiltration；
IV, is by the filtrate after above-mentioned ultrafiltration and absolute ethyl alcohol by volume 1:(1-3) is mixed, then in ultrasonic power
Ultrasonic extraction 10-30min under the conditions of 400-600W, 35-55 DEG C, then at 360-600W Microwave Extraction 5-15min, after the completion of alcohol extracting
Mixed liquor at 40-60 DEG C of temperature is rotated into 1-3h, recycles absolute ethyl alcohol, concentration is until mixeding liquid volume becomes former mixing liquid
Long-pending 1/8-1/6, obtains concentrate；
V, by above-mentioned concentrate in subzero 40 DEG C-it is 30 DEG C subzero at a temperature of be freeze-dried 30-40min, be then ground to
Powder simultaneously crosses 150-250 mesh standard sieves to get fleece-flower root root enzymatic hydrolyzed extract.
The Fructus Viticis extract is prepared by the following method to obtain：By fresh fructus viticis natural air drying, it is crushed to 20-60
Mesh, by 1:(20-80) weight ratio adds in boiling water and carries out 3 decoctions, and decocting time 30-70min decocts hydration simultaneously every time, decompression
40-70 times for wild pepper protonatomic mass is concentrated, adds in the absolute ethyl alcohol of 1-3 times of quality, 4-8h, centrifugation removal are refrigerated at 2-8 DEG C
Precipitation, is then recovered under reduced pressure ethyl alcohol, is concentrated into no alcohol taste, is dried at 50-90 DEG C to constant weight, obtains Fructus Viticis extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, by 80-90wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine,
EDETATE SODIUM is added in homogenizer, homogeneous 10-20min, 80-85 DEG C of whipping temp；
III, will add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature, stir 10-30min；
IV, is cooled to 65-75 DEG C, adds in Cocoamidopropyl betaine, sodium chloride, melon glue Hydroxyproyl Trimethyl chlorination
Ammonium, panthenol, citric acid, stir evenly；
V, is cooled to 45-60 DEG C, adds in remaining water, the agent of hair anticreep, biological bactericide, stirs evenly；
VI, is cooled to 30-40 DEG C, adds in hydrolyzed wheat protein, essence, methylisothiazolinone, stirs evenly；
VIII, is stood, defoaming and quality inspection, after quality inspection qualifications, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
The raw material described in the present invention：
Laureth sulfuric ester ammonium, No. CAS：1335-72-4 is a kind of bay 01 derivatives, often makees in cosmetics
Remover, foaming agent have good foaming characteristic, are usually used in personal cleanliness's articles for use, particularly the product of low ph value, this ingredient
Irritation is relatively low after ethoxylation.
Bay alcohol sulfuric ester ammonium, No. CAS：68955-19-1 belongs to strong detergent ingredient, has stronger cleaning energy
Power, while there is foaming, detergent is used as in cosmetics, the foaming agent being suitable for use as in toothpaste, shampoo, hair washing
Foaming and cleaning ingredients in cream, bubble bath.
Sodium lauroyl sarcosine, No. CAS：137-16-6, is a kind of foaming agent and surfactant, it is by creatine or coffee
Coffee belongs to modified fat acids because of Hamposyl L salt made of decomposition.It frequently appears in shampoo, shower cream, face cleaning
It is used as foaming agent, surfactant and hair conditioner in breast and Shaving Products.Sodium lauroyl sarcosine can be soft by improving
Soft and glossiness, promotes the perception of hair, particularly those by chemical damage hair.The ingredient can be used for cleaning
Skin and hair mix oil and spot and are easier to rinse out.It is considered as often a kind of penetration-assisting agent, thus it is possible to vary skin knot
Structure helps other chemical penetrations to skin depths.
Cocoamidopropyl betaine, No. CAS：61789-40-0 is a kind of amphoteric surfactant, is had good clear
It washes, blister, opsonic action, good with anion, cation and nonionic surfactant compatibility, this product irritation is small, performance
Mildly, foam is fine and smooth and stablizes, and suitable for configuration shampoo, shower cream, facial cleanser etc., can enhance the flexibility to hair, skin,
When this product is with appropriate anion surfactant compatibility, there is apparent thickening effect, also act as conditioner, wetting agent, sterilization
Agent, antistatic agent etc., use in the present invention as detergent.
Glycol distearate, No. CAS：111-55-7 often makees emollients, emulsifier and pearling agent and uses, the ingredient
It can provide product pearlescent gloss, increase product viscosity, also have and moisturize the skin, anlistatig effect, with other types
Surfactant compatibility it is preferable, and stablize, and the ingredient is non-stimulated to skin, in the present invention as pearling agent.
Guar hydroxypropyltrimonium chloride, No. CAS：65497-29-2 is a kind of high molecular weight water soluble polymer, is
It is raw material using natural guars, reacts and be made with dehydration contracting glycerin ether trimethyl ammonia chloride ammonia, make antistatic agent in cosmetics
It uses with film forming agent, is used in this product as conditioner for hair.
Hydrolyzed wheat protein, No. CAS：70084-87-6, containing abundant Cystine, Hydrolyzed Protein, antioxidation and
Softness refinement skin, has special Safflower Oil that can help improve wrinkle, is used in this product as conditioner for hair.
Panthenol, No. CAS：81-13-0 is mainly used as moisturizer and skin conditioning agent, is used together with vitamin B6, percutaneously
Skin can increase hyaluronic acid contents in skin after absorbing, promote the metabolism of human body protein, fat, carbohydrate, protect skin and stick
Film prevents small wrinkle, and inflammation, solarization are not glutinous greasy moisturizing ingredients, have potent moistening effect, and with skin sebum film phase
Closely, it is easy to the cuticula for absorbing infiltration and infiltration skin surface, makes skin soft, effectively prevent the coarse phenomenon of skin, reach flesh
The effect of skin moisturizing and tissue repair, gives skin gloss.
Cetostearyl alcohol, No. CAS：67762-27-0 belongs to fatty alcohol, and appearance is White waxy object, can provide butyrous
Quality is used frequently as emollients, emulsifier, thickener, can be artificial synthesized, can also be extracted from coconut fatty alcohol.The ingredient
Product can be helped to be easier in penetrating to the skin, moreover it is possible to be used as emulsifier, make product more easy to apply, be used as in the present invention
Emollient.
Citric acid, No. CAS：77-92-9, belongs to one kind of tartaric acid, and main function is to speed up cutin update, is usually used in breast
Liquid, creams, shampoo, whitening articles for use, anti-aging articles for use, Acne etc..The update of cutin contributes to the middle black of skin
The peeling of element, the receipts of pore are thin, dissolving of blackhead etc..It is combined with sodium bicarbonate can make foaming bath foam, they are generated
Carbon dioxide, and pleasant bubble is createed, it is used in this product as pH adjusting agent.
Methyl hydroxybenzoate, No. CAS：99-76-3 for parabens preservative, is widely used in cosmetics, nipalgin
The preservative of esters is stronger to the antibacterial action of yeast and mold, slightly worse to the effect of bacterium, mainly by destroying microorganism
Cell membrane, make intracellular protein denaturation, and inhibit cellular respiration enzyme and transmit enzyme system activity and play antibacterial work
With European Union in 2014 provides a concentration of 0.14% when propylben, butyl hydroxybenzoate and its esters are used alone, with other to permit
Perhaps total concentration must not exceed 0.8% when the paraben esters used mix together.
Methylisothiazolinone, abbreviation MIT, No. CAS：2682-20-4 is a kind of preservative without chlorine, can inhibit
The growth of bacterium, fungi and mould just can effectively kill various bacteria, therefore extensive as efficient antiseptic at low concentrations
For in cosmetics and personal-care supplies, ministry of Health of China to provide that its maximum acceptable concentration in cosmetics is 0.01%.
A kind of shampoo of the present invention using natural plant formula, is extracted containing Cacumen Platycladi extract, fleece-flower root root
The plant components such as object, Fructus Viticis extract, gadol extract and Black Ganoderma extract, cleanable scalp dirt, correct leatherware
Have preferable bacteriostasis, while nutrition scalp, help to improve the growing environment of hair, improve the toughness of hair, reduce alopecia,
Disconnected hair has protective effect to the hair of damage, in addition also mild non-stimulated, safe and healthy.
The biological bactericide of the present invention, sterilizing power is strong, and lasting effect is strong, the suppression of biology is killed with obvious effects than each fungicide list
Solely using stronger.
Specific embodiment
The foregoing invention content of the present invention is described in further detail With reference to embodiment, but should not be incited somebody to action
This range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiments.In the present invention, if not refering in particular to, all devices
It is bought from market or for industry commonly used equipment；Experimental method in embodiment is this field routine side unless otherwise instructed
Method.
Disintegrating apparatus uses the 20B type pulverizers of Guangzhou Lai Ang mechanical equipments Co., Ltd production.
Spray drying device rubs (Shanghai) Electronic Science and Technology Co., Ltd. purchased from fine jade, model QIMO-8000T.
The model LWF6-BI of oscillatory type drug micronizer is provided by Jinan Long Wei pharmaceutical equipments Co., Ltd.
Ultrafiltration apparatus uses the HX type ultrafiltration systems of Heng Xin environmental protection equipments Co., Ltd of Jingjiang City manufacture.
Ultrasonic device is BK-600B type supersonic wave cleaning machines, purchased from Bakr Ultrasonic Technology (Group) Co., Ltd..
The model 101-2-BS of electric heating constant-temperature blowing drying box, purchased from Shanghai leap Medical Devices Co., Ltd.
Vacuum freeze drier is the SCIENTZ-12N type vacuum provided by NingBo XinZhi Biology Science Co., Ltd
Freeze drier.
The model DZF of vacuum drying chamber, purchased from upper sea otter jump experimental instruments and equipment limited
Homogenizer uses RHG type high-shear emulsifying tanks, is provided by Wenzhou Machinery Co., Ltd. of New School.
Embodiment 1
A kind of shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulphur
Acid esters ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, Cacumen Platycladi extract 1wt%, fleece-flower root root extract 1wt%, fructus viticis
Extract 1wt%, biological bactericide 1wt%, surplus are water.
The Cacumen Platycladi extract is prepared by the following method to obtain：Arbor-vitae leaf raw material is taken, cleans and is added to the water after drying
It decocts 3 times, first time decocting time is 160min, and second of decocting time is 90min, and third time decocting time is 45min, often
The weight of secondary decoction plus water is 10 times of arbor-vitae leaf raw material, and it is 1.21 to be then concentrated under reduced pressure at a temperature of 50 DEG C into relative density
Concentrate is dried with spray drying process, and inlet air temperature and leaving air temp are respectively 160 DEG C, 70 DEG C, and obtaining cacumen biotae after dry carries
Take object.
The fleece-flower root root extract why Polygonum Multiflorum root enzymatic hydrolyzed extract, the preparation side of the fleece-flower root root enzymatic hydrolyzed extract
Method includes the following steps：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 2 times of quality is added in into fleece-flower root root powder, 30
15min is stirred with 200r/min rotating speeds at a temperature of DEG C, obtains fleece-flower root root powder suspension；
Fleece-flower root root powder suspension obtained above is moved into homogenizer, homogeneous 7min by II, and homogenization pressure is
100MPa adds in the 0.3wt% complex enzyme agent of fleece-flower root root mixed liquor quality in the fleece-flower root mixed liquor after homogeneous, wherein compound
It is 1 in mass ratio by neutral proteinase and cellulase that enzyme agent, which is,：2, then with a concentration of 0.5mo1/L acetums adjust pH to
4.5, the sealing enzymolysis 70min at 40 DEG C is then placed in drying box；
Removal filter residue is separated by filtration after the completion of III, enzymolysis, obtains enzymolysis liquid, will be surpassed under conditions of 25 DEG C of enzymolysis liquid
Filtrate is collected in filter；
Filtrate after above-mentioned ultrafiltration and absolute ethyl alcohol are 1 by volume by IV,:1 is mixed, then in ultrasonic power
Then at 480W Microwave Extraction 10min, rotation is put into after the completion of alcohol extracting by 600W, ultrasonic extraction 20min under the conditions of 45 DEG C for mixed liquor
Evaporator rotates 1.5h at a temperature of 50 DEG C, recycles absolute ethyl alcohol, and concentration is until mixeding liquid volume becomes former mixeding liquid volume
1/8, obtain concentrate；
Above-mentioned concentrate is freeze-dried 35min by V, at a temperature of subzero 35 DEG C, is pulverized after dry and is crossed 200
Mesh standard sieve is to get fleece-flower root root enzymatic hydrolyzed extract.
The Fructus Viticis extract is prepared by the following method to obtain：By fresh fructus viticis natural air drying, 40 mesh are crushed to,
By 1:60 weight ratios add in boiling water and carry out 3 decoctions, and decocting time difference 50min decocts hydration simultaneously, it is climing to be concentrated under reduced pressure every time
60 times of chaste tree protonatomic mass add in the absolute ethyl alcohol of 2 times of quality, and 6h is refrigerated at 2-8 DEG C, and centrifugation removal precipitation then depressurizes back
Ethyl alcohol is received, is concentrated into no alcohol taste, is dried at a temperature of 80 DEG C to constant weight, obtains Fructus Viticis extract.
The biological bactericide is gadol extract and Black Ganoderma extract, and wherein gadol extract and Black Ganoderma carries
It is 1 to take amount of substance ratio：1.
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and is added in after drying
65wt% alcohol refluxs extract 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, and rhodiola root is former during extraction every time
The rate of charge of material and ethyl alcohol is 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, nothing is concentrated into after reduced pressure
Alcohol taste is dried to constant weight at a temperature of 65 DEG C, obtains gadol extract.
The preparation method of the Black Ganoderma extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, powder
40 mesh are broken to, gained Black Ganoderma powder are put into the 95wt% ethanol solutions of 10 times of quality, 12h is impregnated at 30 DEG C, are filtered
It is placed at shady and cool ventilation and air-dries again afterwards；
II, adds in the 1wt% ammonia spirits of 10 times of quality, extracts 2h at 95 DEG C, filtrate, the same condition of filter residue is collected by filtration
It extracts again, merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min, the condenser temperature of vacuum freeze drying in vacuum freeze drier by III,
It it is subzero 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, is by 85wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine, EDTA bis-
Sodium is added in homogenizer, and 15min is stirred under conditions of rotating speed 240r/min, 80 DEG C of temperature；
III, continue into homogenizer add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature and
Rotating speed is constant, stirs 20min；
IV, is cooled to 70 DEG C, add in Cocoamidopropyl betaine, sodium chloride, guar hydroxypropyltrimonium chloride,
Panthenol, citric acid stir 20min with the rotating speed of 200r/min；
V, is down to 50 DEG C when temperature, and adding in remaining water, Cacumen Platycladi extract, fleece-flower root root to above-mentioned mixed solution carries
Object, Fructus Viticis extract, biological bactericide are taken, 20min is stirred with the rotating speed of 200r/min, makes its fully dispersed homogenizing；
VI, adds in hydrolyzed wheat protein, essence, methylisothiazolinone to above-mentioned homogenizer when temperature is 35 DEG C
In, 6min is stirred with the rotating speed of 100r/min, is cooled down while stirring, when being cooled to 27 DEG C, stops stirring；
VIII, is stood, defoaming and quality inspection, after quality inspection qualification, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
Embodiment 2
A kind of shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulphur
Acid esters ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, Cacumen Platycladi extract 1.5wt%, fleece-flower root root extract 1.5wt%, life
Object fungicide 1wt%, surplus are water.
The Cacumen Platycladi extract is prepared by the following method to obtain：Arbor-vitae leaf raw material is taken, cleans and is added to the water after drying
It decocts 3 times, first time decocting time is 160min, and second of decocting time is 90min, and third time decocting time is 45min, often
The weight of secondary decoction plus water is 10 times of arbor-vitae leaf raw material, and it is 1.21 to be then concentrated under reduced pressure at a temperature of 50 DEG C into relative density
Concentrate is dried with spray drying process, and inlet air temperature and leaving air temp are respectively 160 DEG C, 70 DEG C, and obtaining cacumen biotae after dry carries
Take object.
The fleece-flower root root extract why Polygonum Multiflorum root enzymatic hydrolyzed extract, the preparation side of the fleece-flower root root enzymatic hydrolyzed extract
Method includes the following steps：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 2 times of quality is added in into fleece-flower root root powder, 30
15min is stirred with 200r/min rotating speeds at a temperature of DEG C, obtains fleece-flower root root powder suspension；
Fleece-flower root root powder suspension obtained above is moved into homogenizer, homogeneous 7min by II, and homogenization pressure is
100MPa adds in the 0.3wt% complex enzyme agent of fleece-flower root root mixed liquor quality in the fleece-flower root mixed liquor after homogeneous, wherein compound
It is 1 in mass ratio by neutral proteinase and cellulase that enzyme agent, which is,：2, then with a concentration of 0.5mo1/L acetums adjust pH to
4.5, the sealing enzymolysis 70min at 40 DEG C is then placed in drying box；
Removal filter residue is separated by filtration after the completion of III, enzymolysis, obtains enzymolysis liquid, will be surpassed under conditions of 25 DEG C of enzymolysis liquid
Filtrate is collected in filter；
Filtrate after above-mentioned ultrafiltration and absolute ethyl alcohol are 1 by volume by IV,:1 is mixed, then in ultrasonic power
Then at 480W Microwave Extraction 10min, rotation is put into after the completion of alcohol extracting by 600W, ultrasonic extraction 20min under the conditions of 45 DEG C for mixed liquor
Evaporator rotates 1.5h at a temperature of 50 DEG C, recycles absolute ethyl alcohol, and concentration is until mixeding liquid volume becomes former mixeding liquid volume
1/8, obtain concentrate；
Above-mentioned concentrate is freeze-dried 35min by V, at a temperature of subzero 35 DEG C, is pulverized after dry and is crossed 200
Mesh standard sieve is to get fleece-flower root root enzymatic hydrolyzed extract.
The biological bactericide is gadol extract and Black Ganoderma extract, and wherein gadol extract and Black Ganoderma carries
It is 1 to take amount of substance ratio：1.
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and is added in after drying
65wt% alcohol refluxs extract 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, and rhodiola root is former during extraction every time
The rate of charge of material and ethyl alcohol is 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, nothing is concentrated into after reduced pressure
Alcohol taste is dried to constant weight at a temperature of 65 DEG C, obtains gadol extract.
The preparation method of the Black Ganoderma extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, powder
40 mesh are broken to, gained Black Ganoderma powder are put into the 95wt% ethanol solutions of 10 times of quality, 12h is impregnated at 30 DEG C, are filtered
It is placed at shady and cool ventilation and air-dries again afterwards；
II, adds in the 1wt% ammonia spirits of 10 times of quality, extracts 2h at 95 DEG C, filtrate, the same condition of filter residue is collected by filtration
It extracts again, merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min, the condenser temperature of vacuum freeze drying in vacuum freeze drier by III,
It it is subzero 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, is by 85wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine, EDTA bis-
Sodium is added in homogenizer, and 15min is stirred under conditions of rotating speed 240r/min, 80 DEG C of temperature；
III, continue into homogenizer add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature and
Rotating speed is constant, stirs 20min；
IV, is cooled to 70 DEG C, add in Cocoamidopropyl betaine, sodium chloride, guar hydroxypropyltrimonium chloride,
Panthenol, citric acid stir 20min with the rotating speed of 200r/min；
V, is down to 50 DEG C when temperature, and adding in remaining water, Cacumen Platycladi extract, fleece-flower root root to above-mentioned mixed solution carries
Object, biological bactericide are taken, 20min is stirred with the rotating speed of 200r/min, makes its fully dispersed homogenizing；
VI, adds in hydrolyzed wheat protein, essence, methylisothiazolinone to above-mentioned homogenizer when temperature is 35 DEG C
In, 6min is stirred with the rotating speed of 100r/min, is cooled down while stirring, when being cooled to 27 DEG C, stops stirring；
VIII, is stood, defoaming and quality inspection, after quality inspection qualification, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
Embodiment 3
A kind of shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulphur
Acid esters ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, fleece-flower root root extract 1.5wt%, Fructus Viticis extract 1.5wt%, life
Object fungicide 1wt%, surplus are water.
The fleece-flower root root extract why Polygonum Multiflorum root enzymatic hydrolyzed extract, the preparation side of the fleece-flower root root enzymatic hydrolyzed extract
Method includes the following steps：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 2 times of quality is added in into fleece-flower root root powder, 30
15min is stirred with 200r/min rotating speeds at a temperature of DEG C, obtains fleece-flower root root powder suspension；
Fleece-flower root root powder suspension obtained above is moved into homogenizer, homogeneous 7min by II, and homogenization pressure is
100MPa adds in the 0.3wt% complex enzyme agent of fleece-flower root root mixed liquor quality in the fleece-flower root mixed liquor after homogeneous, wherein compound
It is 1 in mass ratio by neutral proteinase and cellulase that enzyme agent, which is,：2, then with a concentration of 0.5mo1/L acetums adjust pH to
4.5, the sealing enzymolysis 70min at 40 DEG C is then placed in drying box；
Removal filter residue is separated by filtration after the completion of III, enzymolysis, obtains enzymolysis liquid, will be surpassed under conditions of 25 DEG C of enzymolysis liquid
Filtrate is collected in filter；
Filtrate after above-mentioned ultrafiltration and absolute ethyl alcohol are 1 by volume by IV,:1 is mixed, then in ultrasonic power
Then at 480W Microwave Extraction 10min, rotation is put into after the completion of alcohol extracting by 600W, ultrasonic extraction 20min under the conditions of 45 DEG C for mixed liquor
Evaporator rotates 1.5h at a temperature of 50 DEG C, recycles absolute ethyl alcohol, and concentration is until mixeding liquid volume becomes former mixeding liquid volume
1/8, obtain concentrate；
Above-mentioned concentrate is freeze-dried 35min by V, at a temperature of subzero 35 DEG C, is pulverized after dry and is crossed 200
Mesh standard sieve is to get fleece-flower root root enzymatic hydrolyzed extract.
The Fructus Viticis extract is prepared by the following method to obtain：By fresh fructus viticis natural air drying, 40 mesh are crushed to,
By 1:60 weight ratios add in boiling water and carry out 3 decoctions, and decocting time difference 50min decocts hydration simultaneously, it is climing to be concentrated under reduced pressure every time
60 times of chaste tree protonatomic mass add in the absolute ethyl alcohol of 2 times of quality, and 6h is refrigerated at 2-8 DEG C, and centrifugation removal precipitation then depressurizes back
Ethyl alcohol is received, is concentrated into no alcohol taste, is dried at a temperature of 80 DEG C to constant weight, obtains Fructus Viticis extract.
The biological bactericide is gadol extract and Black Ganoderma extract, and wherein gadol extract and Black Ganoderma carries
It is 1 to take amount of substance ratio：1.
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and is added in after drying
65wt% alcohol refluxs extract 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, and rhodiola root is former during extraction every time
The rate of charge of material and ethyl alcohol is 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, nothing is concentrated into after reduced pressure
Alcohol taste is dried to constant weight at a temperature of 65 DEG C, obtains gadol extract.
The preparation method of the Black Ganoderma extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, powder
40 mesh are broken to, gained Black Ganoderma powder are put into the 95wt% ethanol solutions of 10 times of quality, 12h is impregnated at 30 DEG C, are filtered
It is placed at shady and cool ventilation and air-dries again afterwards；
II, adds in the 1wt% ammonia spirits of 10 times of quality, extracts 2h, filtrate is collected by filtration, filter residue carries again with condition
It takes, merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min, the condenser temperature of vacuum freeze drying in vacuum freeze drier by III,
It it is subzero 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, is by 85wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine, EDTA bis-
Sodium is added in homogenizer, and 15min is stirred under conditions of rotating speed 240r/min, 80 DEG C of temperature；
III, continue into homogenizer add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature and
Rotating speed is constant, stirs 20min；
IV, is cooled to 70 DEG C, add in Cocoamidopropyl betaine, sodium chloride, guar hydroxypropyltrimonium chloride,
Panthenol, citric acid stir 20min with the rotating speed of 200r/min；
V, is down to 50 DEG C when temperature, and adding in remaining water, fleece-flower root root extract, fructus viticis to above-mentioned mixed solution carries
Object, biological bactericide are taken, 20min is stirred with the rotating speed of 200r/min, makes its fully dispersed homogenizing；
VI, adds in hydrolyzed wheat protein, essence, methylisothiazolinone to above-mentioned homogenizer when temperature is 35 DEG C
In, 6min is stirred with the rotating speed of 100r/min, is cooled down while stirring, when being cooled to 27 DEG C, stops stirring；
VIII, is stood, defoaming and quality inspection, after quality inspection qualification, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
Embodiment 4
A kind of shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulphur
Acid esters ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, Cacumen Platycladi extract 1.5wt%, Fructus Viticis extract 1.5wt%, biology
Fungicide 1wt%, surplus are water.
The Cacumen Platycladi extract is prepared by the following method to obtain：Arbor-vitae leaf raw material is taken, cleans and is added to the water after drying
It decocts 3 times, first time decocting time is 160min, and second of decocting time is 90min, and third time decocting time is 45min, often
The weight of secondary decoction plus water is 10 times of arbor-vitae leaf raw material, and it is 1.21 to be then concentrated under reduced pressure at a temperature of 50 DEG C into relative density
Concentrate is dried with spray drying process, and inlet air temperature and leaving air temp are respectively 160 DEG C, 70 DEG C, and obtaining cacumen biotae after dry carries
Take object.
The Fructus Viticis extract is prepared by the following method to obtain：By fresh fructus viticis natural air drying, 40 mesh are crushed to,
By 1:60 weight ratios add in boiling water and carry out 3 decoctions, and decocting time difference 50min decocts hydration simultaneously, it is climing to be concentrated under reduced pressure every time
60 times of chaste tree protonatomic mass add in the absolute ethyl alcohol of 2 times of quality, and 6h is refrigerated at 2-8 DEG C, and centrifugation removal precipitation then depressurizes back
Ethyl alcohol is received, is concentrated into no alcohol taste, is dried at a temperature of 80 DEG C to constant weight, obtains Fructus Viticis extract.
The biological bactericide is gadol extract and Black Ganoderma extract, and wherein gadol extract and Black Ganoderma carries
It is 1 to take amount of substance ratio：1.
The biological bactericide of the present invention, sterilizing power is strong, and lasting effect is strong, the suppression of biology is killed with obvious effects than each fungicide list
Solely using stronger.
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and is added in after drying
65wt% alcohol refluxs extract 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, and rhodiola root is former during extraction every time
The rate of charge of material and ethyl alcohol is 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, nothing is concentrated into after reduced pressure
Alcohol taste is dried to constant weight at a temperature of 65 DEG C, obtains gadol extract.
The preparation method of the Black Ganoderma extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, powder
40 mesh are broken to, gained Black Ganoderma powder are put into the 95wt% ethanol solutions of 10 times of quality, 12h is impregnated at 30 DEG C, are filtered
It is placed at shady and cool ventilation and air-dries again afterwards；
II, adds in the 1wt% ammonia spirits of 10 times of quality, extracts 2h at 95 DEG C, filtrate, the same condition of filter residue is collected by filtration
It extracts again, merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min, the condenser temperature of vacuum freeze drying in vacuum freeze drier by III,
It it is subzero 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, is by 85wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine, EDTA bis-
Sodium is added in homogenizer, and 15min is stirred under conditions of rotating speed 240r/min, 80 DEG C of temperature；
III, continue into homogenizer add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature and
Rotating speed is constant, stirs 20min；
IV, is cooled to 70 DEG C, add in Cocoamidopropyl betaine, sodium chloride, guar hydroxypropyltrimonium chloride,
Panthenol, citric acid stir 20min with the rotating speed of 200r/min；
V, is down to 50 DEG C when temperature, and adding in remaining water, Cacumen Platycladi extract, fructus viticis to above-mentioned mixed solution extracts
Object, biological bactericide stir 20min with the rotating speed of 200r/min, make its fully dispersed homogenizing；
VI, adds in hydrolyzed wheat protein, essence, methylisothiazolinone to above-mentioned homogenizer when temperature is 35 DEG C
In, 6min is stirred with the rotating speed of 100r/min, is cooled down while stirring, when being cooled to 27 DEG C, stops stirring；
VIII, is stood, defoaming and quality inspection, after quality inspection qualification, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
Comparative example 1
A kind of shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulphur
Acid esters ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, biological bactericide 1wt%, surplus are water.
The biological bactericide is gadol extract and Black Ganoderma extract, and wherein gadol extract and Black Ganoderma carries
It is 1 to take amount of substance ratio：1.
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and is added in after drying
65wt% alcohol refluxs extract 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, and rhodiola root is former during extraction every time
The rate of charge of material and ethyl alcohol is 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, nothing is concentrated into after reduced pressure
Alcohol taste is dried to constant weight at a temperature of 65 DEG C, obtains gadol extract.
The preparation method of the Black Ganoderma extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, powder
40 mesh are broken to, gained Black Ganoderma powder are put into the 95wt% ethanol solutions of 10 times of quality, 12h is impregnated at 30 DEG C, are filtered
It is placed at shady and cool ventilation and air-dries again afterwards；
II, adds in the 1wt% ammonia spirits of 10 times of quality, extracts 2h at 95 DEG C, filtrate, the same condition of filter residue is collected by filtration
It extracts again, merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min, the condenser temperature of vacuum freeze drying in vacuum freeze drier by III,
It it is subzero 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, is by 85wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine, EDTA bis-
Sodium is added in homogenizer, and 15min is stirred under conditions of rotating speed 240r/min, 80 DEG C of temperature；
III, continue into homogenizer add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature and
Rotating speed is constant, stirs 20min；
IV, is cooled to 70 DEG C, add in Cocoamidopropyl betaine, sodium chloride, guar hydroxypropyltrimonium chloride,
Panthenol, citric acid stir 20min with the rotating speed of 200r/min；
V, is down to 50 DEG C when temperature, remaining water, biological bactericide is added in above-mentioned mixed solution, with 200r/min's
Rotating speed stirs 20min, makes its fully dispersed homogenizing；
VI, adds in hydrolyzed wheat protein, essence, methylisothiazolinone to above-mentioned homogenizer when temperature is 35 DEG C
In, 6min is stirred with the rotating speed of 100r/min, is cooled down while stirring, when being cooled to 27 DEG C, stops stirring；
VIII, is stood, defoaming and quality inspection, after quality inspection qualification, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
Embodiment 5
It is substantially the same manner as Example 1, it differs only in：The fleece-flower root root extract why Polygonum Multiflorum root impalpable powder, institute
The preparation process for stating fleece-flower root root impalpable powder is：After fleece-flower root root is taken to clean, 20 mesh are crushed to, oscillatory type drug is subsequently placed in and surpasses
In atomizer under conditions of subzero 10 DEG C ultramicro grinding 45min, it is 12 μm of fleece-flower root root impalpable powder to obtain average grain diameter.
Embodiment 6
It is substantially the same manner as Example 1, it differs only in：The preparation method of the fleece-flower root root enzymatic hydrolyzed extract include with
Lower step：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 2 times of quality is added in into fleece-flower root root powder, 30
15min is stirred with 200r/min rotating speeds at a temperature of DEG C, obtains fleece-flower root root powder suspension；
Fleece-flower root root powder suspension obtained above is moved into homogenizer, homogeneous 7min by II, and homogenization pressure is
100MPa adds in the 0.3wt% complex enzyme agent of fleece-flower root root mixed liquor quality in the fleece-flower root mixed liquor after homogeneous, wherein compound
It is 1 in mass ratio by neutral proteinase and cellulase that enzyme agent, which is,：2, then with a concentration of 0.5mo1/L acetums adjust pH to
4.5, the sealing enzymolysis 70min at 40 DEG C is then placed in drying box；
Removal filter residue is separated by filtration after the completion of III, enzymolysis, obtains enzymolysis liquid, will be surpassed under conditions of 25 DEG C of enzymolysis liquid
Filtrate is collected in filter；
Above-mentioned filtrate is put into rotary evaporator by IV, and 1.5h is rotated at a temperature of 50 DEG C, recycles absolute ethyl alcohol, and concentration is straight
Become the 1/8 of original volume to mixeding liquid volume, obtain concentrate；
Above-mentioned concentrate is freeze-dried 35min by V, at a temperature of subzero 35 DEG C, is pulverized after dry and is crossed 200
Mesh standard sieve is to get fleece-flower root root enzymatic hydrolyzed extract.
Embodiment 7
It is substantially the same manner as Example 1, it differs only in：The biological bactericide be gadol extract, the red scape
Its extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and 65wt% alcohol refluxs extraction 3 is added in after drying
Secondary, extraction time 75min, each Extracting temperature is 50 DEG C, and the rate of charge of rhodiola root raw material and ethyl alcohol is during extraction every time
1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, no alcohol taste is concentrated into after reduced pressure, done at a temperature of 65 DEG C
It is dry to constant weight, obtain gadol extract.
Embodiment 8
It is substantially the same manner as Example 1, it differs only in：The biological bactericide be Black Ganoderma extract, the black spirit
The preparation method of sesame extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, powder
40 mesh are broken to, gained Black Ganoderma powder are put into the 95wt% ethanol solutions of 10 times of quality, 12h is impregnated at 30 DEG C, are filtered
It is placed at shady and cool ventilation and air-dries again afterwards；
II, adds in the 1wt% ammonia spirits of 10 times of quality, extracts 2h at 95 DEG C, filtrate, the same condition of filter residue is collected by filtration
It extracts again, merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min, the condenser temperature of vacuum freeze drying in vacuum freeze drier by III,
It it is subzero 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and is added in after drying
65wt% alcohol refluxs extract 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, and rhodiola root is former during extraction every time
The rate of charge of material and ethyl alcohol is 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, nothing is concentrated into after reduced pressure
Alcohol taste is dried to constant weight at a temperature of 65 DEG C, obtains gadol extract.
Comparative example 2
A kind of shampoo is made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulphur
Acid esters ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, Cacumen Platycladi extract 1wt%, fleece-flower root root extract 1wt%, fructus viticis
Extract 1wt%, surplus are water.
The Cacumen Platycladi extract is prepared by the following method to obtain：Arbor-vitae leaf raw material is taken, cleans and is added to the water after drying
It decocts 3 times, first time decocting time is 160min, and second of decocting time is 90min, and third time decocting time is 45min, often
The weight of secondary decoction plus water is 10 times of arbor-vitae leaf raw material, and it is 1.21 to be then concentrated under reduced pressure at a temperature of 50 DEG C into relative density
Concentrate is dried with spray drying process, and inlet air temperature and leaving air temp are respectively 160 DEG C, 70 DEG C, and obtaining cacumen biotae after dry carries
Take object.
The fleece-flower root root extract why Polygonum Multiflorum root enzymatic hydrolyzed extract, the preparation side of the fleece-flower root root enzymatic hydrolyzed extract
Method includes the following steps：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 2 times of quality is added in into fleece-flower root root powder, 30
15min is stirred with 200r/min rotating speeds at a temperature of DEG C, obtains fleece-flower root root powder suspension；
Fleece-flower root root powder suspension obtained above is moved into homogenizer, homogeneous 7min by II, and homogenization pressure is
100MPa adds in the 0.3wt% complex enzyme agent of fleece-flower root root mixed liquor quality in the fleece-flower root mixed liquor after homogeneous, wherein compound
It is 1 in mass ratio by neutral proteinase and cellulase that enzyme agent, which is,：2, then with a concentration of 0.5mo1/L acetums adjust pH to
4.5, the sealing enzymolysis 70min at 40 DEG C is then placed in drying box；
Removal filter residue is separated by filtration after the completion of III, enzymolysis, obtains enzymolysis liquid, will be surpassed under conditions of 25 DEG C of enzymolysis liquid
Filtrate is collected in filter；
Filtrate after above-mentioned ultrafiltration and absolute ethyl alcohol are 1 by volume by IV,:1 is mixed, then in ultrasonic power
Then at 480W Microwave Extraction 10min, rotation is put into after the completion of alcohol extracting by 600W, ultrasonic extraction 20min under the conditions of 45 DEG C for mixed liquor
Evaporator rotates 1.5h at a temperature of 50 DEG C, recycles absolute ethyl alcohol, and concentration is until mixeding liquid volume becomes former mixeding liquid volume
1/8, obtain concentrate；
Above-mentioned concentrate is freeze-dried 35min by V, at a temperature of subzero 35 DEG C, is pulverized after dry and is crossed 200
Mesh standard sieve is to get fleece-flower root root enzymatic hydrolyzed extract.
The Fructus Viticis extract is prepared by the following method to obtain：By fresh fructus viticis natural air drying, 40 mesh are crushed to,
By 1:60 weight ratios add in boiling water and carry out 3 decoctions, and decocting time difference 50min decocts hydration simultaneously, it is climing to be concentrated under reduced pressure every time
60 times of chaste tree protonatomic mass add in the absolute ethyl alcohol of 2 times of quality, and 6h is refrigerated at 2-8 DEG C, and centrifugation removal precipitation then depressurizes back
Ethyl alcohol is received, is concentrated into no alcohol taste, is dried at a temperature of 80 DEG C to constant weight, obtains Fructus Viticis extract.
A kind of production technology of shampoo, includes the following steps：
I, weighs each component raw material by formula；
II, is by 85wt% water, laureth sulfuric ester ammonium, bay alcohol sulfuric ester ammonium, sodium lauroyl sarcosine, EDTA bis-
Sodium is added in homogenizer, and 15min is stirred under conditions of rotating speed 240r/min, 80 DEG C of temperature；
III, continue into homogenizer add in glycol distearate, cetostearyl alcohol, methyl hydroxybenzoate, keep temperature and
Rotating speed is constant, stirs 20min；
IV, is cooled to 70 DEG C, add in Cocoamidopropyl betaine, sodium chloride, guar hydroxypropyltrimonium chloride,
Panthenol, citric acid stir 20min with the rotating speed of 200r/min；
V, is down to 50 DEG C when temperature, and adding in remaining water, Cacumen Platycladi extract, fleece-flower root root to above-mentioned mixed solution carries
Object, Fructus Viticis extract are taken, 20min is stirred with the rotating speed of 200r/min, makes its fully dispersed homogenizing；
VI, adds in hydrolyzed wheat protein, essence, methylisothiazolinone to above-mentioned homogenizer when temperature is 35 DEG C
In, 6min is stirred with the rotating speed of 100r/min, is cooled down while stirring, when being cooled to 27 DEG C, stops stirring；
VIII, is stood, defoaming and quality inspection, after quality inspection qualification, is transported to bottling department, is carried out by specified amount filling, is had one's hair wash
Water.
Test case 1
The measure of Stibene-glucoside, emodin content：The fleece-flower root also known as knotweed, purple black rattan, Polygonum multiflower knotweed etc. are spent more, be polygonaceae
The fleece-flower root is added in washing product the telangiectasis that can make head, prevents hair from bleaching, can increase by knotweed race liana
Add the nutrition of hair, improve the toughness of hair, reduce alopecia, disconnected hair, there is protective effect to the hair of damage, because of the fleece-flower root
Active ingredient in Stibene-glucoside, dissociated anthraquinone (such as rheum emodin), lecithin.With reference to the journal of writings of Chen Qingtang《He Shou
The changes of contents of 5 kinds of chemical compositions in black concocting process》In experimental method in 2 sections to the hexichol of shampoo in embodiment 1-8
Ethylene glycosides, emodin content are measured.
Table 1：The measure of Stibene-glucoside, emodin content
| Stibene-glucoside (mg/g) | Rheum emodin (mg/g) | |
| Embodiment 1 | 0.16 | 0.037 |
| Embodiment 4 | 0 | 0 |
| Embodiment 5 | 0.04 | 0.015 |
| Embodiment 6 | 0.08 | 0.021 |
As shown in Table 1, embodiment 1 (fleece-flower root root extract is prepared by enzymolysis, ultrasonic microwave collaboration extraction)
In per g shampoos in containing 0.12mg Stibene-glucosides, 0.037mg rheum emodins, all higher than (the direct powder of fleece-flower root root of embodiment 5
Be broken into impalpable powder), embodiment 6 (fleece-flower root root extract only by enzymolysis be prepared) and embodiment 4 be (without fleece-flower root root
Extract), this is probably due in fleece-flower root root impalpable powder without separation, purification process, macromolecular substances and other impurity
It is more, and fleece-flower root root is purified by processes such as enzymolysis, ultrasonic microwave collaboration extractions, has been efficiently extracted active constituent and has been contained
Amount obtains the fleece-flower root root extract of higher purity.
Test case 2
Anticreep efficacy test：In order to verify the anticreep effect of shampoo obtained by the present invention, the side for selecting human body directly on probation
Formula carries out contrast test.450 female volunteers are screened, at 18-50 Sui, there is apparent hair loss phenomenon at the age, average daily
Hair loss 100-300 roots.Using single blind test form, 450 volunteers are randomly divided into 9 groups, each 50 people of group, difference
Using shampoo (embodiment 1-8 and comparative example 1) obtained by the present invention, hair washing is primary daily.Without using any to knot during experiment
Other influential cosmetics of fruit, drug and health products；Can be very well by the requirement compatibility test of testing program, the energy during research
Keep regularity in one's life.Using follow-up is carried out after 1 month one by one, hair loss situation is counted, concrete condition is shown in Table 3：
SS：" effective ", after one month, hair loss phenomenon has certain alleviation, and hair loss weight ratio reduces；" nothing
Effect ", after one month, hair loss phenomenon is without any alleviation or even hair loss more serious situation occurs.Effective percentage calculates public
Formula：
Effective percentage=efficiently individual quantity/total number of persons × 100%.
Table 2：Anticreep effect situation
| Effective percentage/% | |
| Embodiment 1 | 85 |
| Embodiment 2 | 72 |
| Embodiment 3 | 71 |
| Embodiment 4 | 73 |
| Embodiment 5 | 78 |
| Embodiment 6 | 79 |
| Embodiment 7 | 82 |
| Embodiment 8 | 81 |
| Comparative example 1 | 65 |
It can be obtained from 2 interpretation of result of table, using 1 shampoo of embodiment in the present invention using Cacumen Platycladi extract, fleece-flower root root
Extract, the hair anticreep agent of Fructus Viticis extract combination, alopecia cure rate highest reach 85%, and use embodiment 2-4
(agent of hair anticreep is by Cacumen Platycladi extract, fleece-flower root root extract, the arbitrary two kinds of combinations of Fructus Viticis extract) and comparative example 1
The cure rate of (agent of hair anticreep is not used) shampoo is respectively 72%, 71%, 73%, 64%, it is clear that in the embodiment of the present invention 1
The anticreep effect of shampoo is more notable.
Test case 3
Stability, bactericidal properties detection：The stability of shampoo that is obtained to embodiment 1-8 and comparative example 2, bactericidal property
It is detected.Stability test：With reference to the journal of writings of Cao Yingfen《The double gel-type emulsion of emulsifier-free answering in cosmetics
With》The stability of shampoo is measured in the Detection of Stability method present invention in middle 2.2.2.2 section, shampoo is placed in-
In 15 DEG C of refrigerators for 24 hours, it takes out and is placed in room temperature again for 24 hours, for 1 cycle.Continuous 3 cycle of detection.It is by visual observations product first
No layering, then observe whether product is stablized by viscosity measurements.Sterilization test：According to GBl5979-2002, washed what is prepared
After shampoo places 20min at room temperature, its sterilizing rate is tested, tests main microorganism as Escherichia coli (ATCC 25922)
With staphylococcus aureus (ATCC 6538).
The bactericidal effect of the shampoo of embodiment 1-8 and comparative example 2 is tested.Concrete outcome is shown in Table 3.
Table 3：The sterilizing rate test result table of shampoo
As shown in Table 3, present invention hair washing water stability is preferable.The sterilizing rate of comparing embodiment 1,7-8 and comparative example 2
It is found that 1 shampoo of embodiment, using gadol extract and the biological bactericide of Black Ganoderma extract combination, bactericidal effect will
Better than exclusive use gadol extract or Black Ganoderma extract and the comparative example for being not added with biological bactericide in embodiment 7-8
2 bactericidal effect.The biological bactericide of the present invention, sterilizing power is strong, and lasting effect is strong, the suppression of biology is killed with obvious effects than each sterilization
Agent is used alone stronger.
Claims (8)
1. a kind of biological bactericide is gadol extract and/or Black Ganoderma extract.
2. a kind of biological bactericide as described in claim 1 is gadol extract and Black Ganoderma extract (1- in mass ratio
10)：(1-10) is mixed；Preferably, gadol extract and Black Ganoderma extract are (1-3) in mass ratio：(1-3)；Most
Excellent, gadol extract and Black Ganoderma extract are 1 in mass ratio：1.
3. a kind of biological bactericide as claimed in claim 1 or 2, which is characterized in that the gadol extract passes through following
Method is prepared：Rhodiola root raw material is taken, is cleaned and 50-80wt% alcohol refluxs are added in after drying is extracted 1-3 times, extraction time is
65-85min, each Extracting temperature are 40-60 DEG C, and the rate of charge of rhodiola root raw material and ethyl alcohol is 1 during extraction every time：(5-12)
(g/ml), it is filtered after the completion of extraction, is then combined with extracting solution, dried after reduced pressure to constant weight, obtain the rhodiola root extraction
Object.
A kind of 4. biological bactericide as claimed in claim 1 or 2, which is characterized in that the preparation side of the Black Ganoderma extract
Method includes the following steps：
I, is dried after Black Ganoderma fructification is sliced, and is then crushed to 30-60 mesh, is obtained Black Ganoderma powder；
II, adds in the extractant of 6-14 times of quality into above-mentioned Black Ganoderma powder, extracts 1-3h at 90-98 DEG C, is collected by filtration
Filtrate, filter residue extract again with condition, merge filtrate twice, obtain Black Ganoderma extracting solution；
Above-mentioned Black Ganoderma extracting solution is dried 2-10h by III, obtains the Black Ganoderma extract.
5. a kind of biological bactericide as claimed in claim 4, which is characterized in that the extractant is in ethyl alcohol, ammonium hydroxide or water
It is one or more；The drying mode of the Black Ganoderma extracting solution is one kind in heated-air drying, freeze-drying and vacuum drying
It is or a variety of.
6. purposes of the biological bactericide as described in any one of claim 1-5 in daily chemical product.
7. purposes of the biological bactericide as claimed in claim 6 in daily chemical product, which is characterized in that the daily chemical product is
Shampoo, hair conditioner, liquid detergent, shower cream, hair gel or skin care face cream.
8. purposes of the biological bactericide as claimed in claim 6 in daily chemical product, which is characterized in that the daily chemical product is
Shampoo, the shampoo are made of the raw material of following components by weight percent：Laureth sulfuric ester ammonium 7wt%, laruyl alcohol sulfuric acid
Ester ammonium 7wt%, sodium lauroyl sarcosine 2.5wt%, Cocoamidopropyl betaine 1.5wt%, glycol distearate
1.2wt%, guar hydroxypropyltrimonium chloride 1wt%, sodium chloride 0.75wt%, hydrolyzed wheat protein 0.5wt%, essence
0.4wt%, panthenol 0.3wt%, cetostearyl alcohol 0.3wt%, citric acid 0.15wt%, EDETATE SODIUM 0.1wt%, methyl hydroxybenzoate
0.06wt%, methylisothiazolinone 0.006wt%, Cacumen Platycladi extract 1wt%, fleece-flower root root extract 1wt%, fructus viticis
Extract 1wt%, biological bactericide 1wt%, surplus are water；
The Cacumen Platycladi extract is prepared by the following method to obtain：Arbor-vitae leaf raw material is taken, cleans and is added to the water decoction 3 after drying
Secondary, first time decocting time is 160min, and second of decocting time is 90min, and third time decocting time is 45min, is decocted every time
It boils plus the weight of water is 10 times of arbor-vitae leaf raw material, be then concentrated under reduced pressure at a temperature of 50 DEG C into the concentration that relative density is 1.21
Liquid is dried with spray drying process, and inlet air temperature and leaving air temp are respectively 160 DEG C, 70 DEG C, and cacumen biotae extraction is obtained after dry
Object；
The fleece-flower root root extract why Polygonum Multiflorum root enzymatic hydrolyzed extract, the preparation method packet of the fleece-flower root root enzymatic hydrolyzed extract
Include following steps：
I, is weighed to dry after fleece-flower root root is cleaned and be crushed, and the water of 2 times of quality is added in into fleece-flower root root powder, at 30 DEG C
At a temperature of 15min is stirred with 200r/min rotating speeds, obtain fleece-flower root root powder suspension；
II, by fleece-flower root root powder suspension obtained above move into homogenizer, homogeneous 7min, homogenization pressure 100MPa,
In fleece-flower root mixed liquor after matter add in fleece-flower root root mixed liquor quality 0.3wt% complex enzyme agent, wherein complex enzyme agent be by
Neutral proteinase and cellulase are 1 in mass ratio：2, then pH to 4.5 is adjusted with a concentration of 0.5mo1/L acetums, then
The sealing enzymolysis 70min at 40 DEG C is placed in drying box；
Removal filter residue is separated by filtration after the completion of III, enzymolysis, obtains enzymolysis liquid, ultrafiltration will be carried out under conditions of 25 DEG C of enzymolysis liquid, received
Collect filtrate；
Filtrate after above-mentioned ultrafiltration and absolute ethyl alcohol are 1 by volume by IV,:1 is mixed, then in ultrasonic power 600W,
Then at 480W Microwave Extraction 10min, rotary evaporation is put into after the completion of alcohol extracting by ultrasonic extraction 20min under the conditions of 45 DEG C for mixed liquor
Device rotates 1.5h at a temperature of 50 DEG C, recycles absolute ethyl alcohol, and concentration becomes the 1/8 of former mixeding liquid volume up to mixeding liquid volume,
Obtain concentrate；
Above-mentioned concentrate is freeze-dried 35min by V, at a temperature of subzero 35 DEG C, is pulverized after dry and is crossed 200 targets
Quasi- sieve is to get fleece-flower root root enzymatic hydrolyzed extract；
The Fructus Viticis extract is prepared by the following method to obtain：By fresh fructus viticis natural air drying, 40 mesh are crushed to, by 1:
60 weight ratios add in boiling water and carry out 3 decoctions, and decocting time difference 50min decocts hydration simultaneously every time, is concentrated under reduced pressure as fructus viticis
60 times of quality add in the absolute ethyl alcohol of 2 times of quality, and 6h is refrigerated at 2-8 DEG C, and second is then recovered under reduced pressure in centrifugation removal precipitation
Alcohol is concentrated into no alcohol taste, is dried at a temperature of 80 DEG C to constant weight, obtains Fructus Viticis extract；
The biological bactericide is gadol extract and Black Ganoderma extract, wherein gadol extract and Black Ganoderma extract
Mass ratio is 1：1；
The gadol extract is prepared by the following method to obtain：Rhodiola root raw material is taken, cleans and 65wt% second is added in after drying
Alcohol reflux extracts 3 times, extraction time 75min, and each Extracting temperature is 50 DEG C, every time rhodiola root raw material and ethyl alcohol during extraction
Rate of charge be 1：8 (g/ml) are filtered after the completion of extraction, are then combined with extracting solution, no alcohol taste are concentrated into after reduced pressure, 65
It is dried at a temperature of DEG C to constant weight, obtains gadol extract；
The preparation method of the Black Ganoderma extract includes the following steps：
I, is put into baking oven after Black Ganoderma fructification is sliced and dries, and then puts into pulverizer and carries out fine crushing, is crushed to
Gained Black Ganoderma powder is put into the 95wt% ethanol solutions of 10 times of quality by 40 mesh, impregnates 12h at 30 DEG C, after suction filtration again
It is placed at shady and cool ventilation and air-dries；
II, adds in the 1wt% ammonia spirits of 10 times of quality, and 2h is extracted at 95 DEG C, is collected by filtration filtrate, filter residue with condition again
Extraction merges filtrate twice；
Above-mentioned filtrate is placed in progress pre-freeze 40min in vacuum freeze drier by III, and the condenser temperature of vacuum freeze drying is zero
Lower 55 DEG C, vacuum degree 0.19Pa, dry 7h obtains the Black Ganoderma extract.
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