CN106795150B - 1,3,4-噻二唑化合物及其在治疗癌症中的用途 - Google Patents
1,3,4-噻二唑化合物及其在治疗癌症中的用途 Download PDFInfo
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- CN106795150B CN106795150B CN201580041233.9A CN201580041233A CN106795150B CN 106795150 B CN106795150 B CN 106795150B CN 201580041233 A CN201580041233 A CN 201580041233A CN 106795150 B CN106795150 B CN 106795150B
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- acetamide
- amino
- thiadiazol
- methoxy
- phenyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1409624.2 | 2014-05-30 | ||
| GBGB1409624.2A GB201409624D0 (en) | 2014-05-30 | 2014-05-30 | 1,3,4-thiadiazole compounds and their use in treating cancer |
| PCT/GB2015/051537 WO2015181539A1 (en) | 2014-05-30 | 2015-05-27 | 1, 3, 4-thiadiazole compounds and their use in treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106795150A CN106795150A (zh) | 2017-05-31 |
| CN106795150B true CN106795150B (zh) | 2019-10-15 |
Family
ID=51214473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580041233.9A Active CN106795150B (zh) | 2014-05-30 | 2015-05-27 | 1,3,4-噻二唑化合物及其在治疗癌症中的用途 |
Country Status (40)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201520959D0 (en) | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
| US9938265B2 (en) * | 2015-11-30 | 2018-04-10 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| US10323028B2 (en) | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| US10040789B2 (en) * | 2015-11-30 | 2018-08-07 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| JP7275053B2 (ja) * | 2017-06-13 | 2023-05-17 | メッドシャイン ディスカバリー インコーポレイテッド | Ｇｌｓ１阻害剤としての化合物 |
| JP2019064976A (ja) * | 2017-10-03 | 2019-04-25 | 国立大学法人 熊本大学 | 抗がん剤 |
| JP7026852B2 (ja) * | 2018-10-16 | 2022-02-28 | メッドシャイン ディスカバリー インコーポレイテッド | チアジアゾール誘導体及びｇｌｓ１阻害剤としてのその使用 |
| CN113508118B (zh) * | 2019-03-05 | 2024-07-19 | 阿斯利康(瑞典)有限公司 | 用作抗癌剂的稠合三环化合物 |
| WO2024233839A1 (en) * | 2023-05-10 | 2024-11-14 | Leal Therapeutics, Inc. | Small molecule inhibitors of glutaminase |
| CN116854582B (zh) * | 2023-07-10 | 2025-08-29 | 泰州葛林美克医药科技有限公司 | 一种对映纯α-甲氧基苯乙酸的制备方法 |
| CN117003745B (zh) * | 2023-07-20 | 2024-06-07 | 南京市第一医院 | Gls1/hdac双靶点抑制剂及其合成方法和应用 |
| WO2025196447A1 (en) | 2024-03-22 | 2025-09-25 | Sitryx Therapeutics Limited | Thiadiazoles as glutaminase 1 inhibitors |
| WO2025196446A1 (en) | 2024-03-22 | 2025-09-25 | Sitryx Therapeutics Limited | Thiadiazoles as glutaminase 1 inhibitors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013078123A1 (en) * | 2011-11-21 | 2013-05-30 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| US20140142081A1 (en) * | 2012-11-22 | 2014-05-22 | Agios Pharmaceuticals, Inc | Compounds and their methods of use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60332475D1 (de) * | 2002-10-30 | 2010-06-17 | Vertex Pharma | Zusammensetzungen verwendbar für die hemmung von rock und anderen kinasen |
| WO2012170664A2 (en) | 2011-06-10 | 2012-12-13 | President And Fellows Of Harvard College | Methods of cancer treatment and prevention through the modulation of sirt4 activity |
| EP2895623B1 (en) * | 2012-09-17 | 2018-08-22 | Agios Pharmaceuticals, Inc. | Use of e-cadherin and vimentin for selection of treatment responsive patients |
| RS62447B1 (sr) | 2012-11-16 | 2021-11-30 | Calithera Biosciences Inc | Heterociklični inhibitori glutaminaze |
| EP2922832B1 (en) | 2012-11-21 | 2019-10-09 | Agios Pharmaceuticals, Inc. | Glutaminase inhibitors and methods of use |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| CA2892817A1 (en) | 2012-12-03 | 2014-06-12 | Calithera Biosciences Inc. | Treatment of cancer with heterocyclic inhibitors of glutaminase |
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2014
- 2014-05-30 GB GBGB1409624.2A patent/GB201409624D0/en not_active Ceased
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2015
- 2015-05-27 BR BR112016028002-4A patent/BR112016028002B1/pt active IP Right Grant
- 2015-05-27 PE PE2016002393A patent/PE20170148A1/es unknown
- 2015-05-27 PL PL15726266T patent/PL3148994T3/pl unknown
- 2015-05-27 EP EP15726266.8A patent/EP3148994B1/en active Active
- 2015-05-27 KR KR1020167036577A patent/KR20170005875A/ko not_active Abandoned
- 2015-05-27 HU HUE15726266A patent/HUE039879T2/hu unknown
- 2015-05-27 LT LTEP15726266.8T patent/LT3148994T/lt unknown
- 2015-05-27 DK DK15726266.8T patent/DK3148994T3/en active
- 2015-05-27 CA CA2949598A patent/CA2949598C/en active Active
- 2015-05-27 HR HRP20181490TT patent/HRP20181490T1/hr unknown
- 2015-05-27 SI SI201530403T patent/SI3148994T1/sl unknown
- 2015-05-27 SG SG11201609880QA patent/SG11201609880QA/en unknown
- 2015-05-27 ES ES15726266.8T patent/ES2688396T3/es active Active
- 2015-05-27 AP AP2016009578A patent/AP2016009578A0/en unknown
- 2015-05-27 JP JP2017514983A patent/JP6538830B2/ja active Active
- 2015-05-27 MY MYPI2016704405A patent/MY192861A/en unknown
- 2015-05-27 EA EA201692260A patent/EA030937B1/ru not_active IP Right Cessation
- 2015-05-27 AU AU2015265703A patent/AU2015265703B2/en active Active
- 2015-05-27 MX MX2016015738A patent/MX2016015738A/es unknown
- 2015-05-27 PT PT15726266T patent/PT3148994T/pt unknown
- 2015-05-27 NZ NZ726790A patent/NZ726790A/en not_active IP Right Cessation
- 2015-05-27 TN TN2016000511A patent/TN2016000511A1/en unknown
- 2015-05-27 US US15/314,562 patent/US10040788B2/en active Active
- 2015-05-27 CR CR20160558A patent/CR20160558A/es unknown
- 2015-05-27 RS RS20181101A patent/RS57876B1/sr unknown
- 2015-05-27 SM SM20180516T patent/SMT201800516T1/it unknown
- 2015-05-27 WO PCT/GB2015/051537 patent/WO2015181539A1/en not_active Ceased
- 2015-05-27 CN CN201580041233.9A patent/CN106795150B/zh active Active
- 2015-05-28 UY UY0001036145A patent/UY36145A/es not_active Application Discontinuation
- 2015-05-29 TW TW104117531A patent/TWI693220B/zh not_active IP Right Cessation
- 2015-05-29 AR ARP150101720A patent/AR100694A1/es unknown
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2016
- 2016-11-17 IL IL249020A patent/IL249020B/en active IP Right Grant
- 2016-11-23 DO DO2016000308A patent/DOP2016000308A/es unknown
- 2016-11-28 GT GT201600250A patent/GT201600250A/es unknown
- 2016-11-29 CL CL2016003074A patent/CL2016003074A1/es unknown
- 2016-11-30 NI NI201600176A patent/NI201600176A/es unknown
- 2016-11-30 SV SV2016005330A patent/SV2016005330A/es unknown
- 2016-12-01 PH PH12016502394A patent/PH12016502394A1/en unknown
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2018
- 2018-07-02 US US16/025,455 patent/US10294221B2/en active Active
- 2018-09-20 CY CY181100975T patent/CY1120836T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013078123A1 (en) * | 2011-11-21 | 2013-05-30 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| US20140142081A1 (en) * | 2012-11-22 | 2014-05-22 | Agios Pharmaceuticals, Inc | Compounds and their methods of use |
Non-Patent Citations (1)
| Title |
|---|
| Small Molecule Glutaminase Inhibitors Block Glutamate Release from Stimulated Microglia;Ajit G. Thomas，等;《Biochem. Biophys. Res. Commun》;20140103;第443卷(第1期);第32–36页 * |
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