CN106729095A - A kind of antifatigue medicament of Radix Sorghum vulgare Pers and preparation method thereof - Google Patents
A kind of antifatigue medicament of Radix Sorghum vulgare Pers and preparation method thereof Download PDFInfo
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Abstract
A kind of antifatigue medicament of Radix Sorghum vulgare Pers and preparation method thereof, is related to Chinese drugs agentia.The raw material of the antifatigue medicament of Radix Sorghum vulgare Pers is Radix Sorghum vulgare Pers.The raw material may also include auxiliary material, and the auxiliary material includes but is not limited at least one in clover leaching liquor, citric acid, white granulated sugar, vitamin C, potassium sorbate, honey, stevioside etc..The formulation of the antifatigue medicament of Radix Sorghum vulgare Pers can be the one kind in the formulations such as decoction, oral liquid, granule, tablet, pill, paste.After Radix Sorghum vulgare Pers are cleaned, dry, pulverize, sieve, obtain Radix Sorghum vulgare Pers powder, the requirement further according to formulation is further processed into the antifatigue medicament of Radix Sorghum vulgare Pers of various formulations.Other formulations need to be such as made, can be processed by existing common process.
Description
Technical field
The present invention relates to Chinese drugs agentia, more particularly, to antifatigue medicament of a kind of Radix Sorghum vulgare Pers and preparation method thereof.
Background technology
The key factor of human health is endangered as 21 century, fatigue is just gradually causing the concern of people.Cured for the modern times
Be defined as fatigue in 2011 caused by excessive body or cerebration by tired concept, fatigue association of Japan
The decline of ability and efficiency, shows body activity and Mental task respectively.
Sorghum (also known as black standing grain, chinese sorghum, another name for Sichuan Province sorghum) is grass family sorghum annual herb plant, in China existing five or six thousand
The plantation history in year, is one of ancient cereal crops of China.Sorghum has certain medicinal curative effect function, and the traditional Chinese medical science thinks sorghum
Property sweet taste, it is slightly cold, has functions that and stomach, invigorating the spleen, disperse accumulations.Sorghum is simultaneous crop that is edible, feeding, brewageing, be machined in one,
In recent years, with the enhancing and the popularization of nutrient knowledge of national health consciousness, the health importance of " supporting vital QI with five kinds of grains " is by increasingly
Many people recognize and receive.The healthy nutritive value of sorghum and production application value are received more and more attention.
The current pharmaceutical research on Radix Sorghum vulgare Pers is less, and Radix Sorghum vulgare Pers show in antibechic, eliminating the phlegm, suppressing panting calming medicine is prepared,
The position with blood coagulation resisting function has good antioxidation activity simultaneously in sorghum root extract, is Radix Sorghum vulgare Pers medicine-food two-purpose
Develop the condition that provides the foundation.Chinese patent CN102600390A discloses a kind of sorghum root extract, and matter is contained in the extract
Amount percentage is 2.2%~3.5% cyanogenic glycoside, disclosed sorghum root extract validity, security be good, cheap,
Preparation method is simple, low production cost.Results of pharmacodynamic test shows：The effect that the invention has antibechic, eliminating the phlegm, relievings asthma, can
Medicine for preparing treatment respiratory disease, its antibechic effect has exceeded codeine phosphate.
The content of the invention
It is an object of the invention to provide antifatigue medicament of a kind of Radix Sorghum vulgare Pers and preparation method thereof.
The raw material of the antifatigue medicament of Radix Sorghum vulgare Pers is Radix Sorghum vulgare Pers.The raw material may also include auxiliary material, and the auxiliary material includes
But it is not limited in clover leaching liquor, citric acid, white granulated sugar, vitamin C, potassium sorbate, honey, stevioside etc. at least one
Kind.
The formulation of the antifatigue medicament of Radix Sorghum vulgare Pers can be the formulations such as decoction, oral liquid, granule, tablet, pill, paste
In one kind.
The preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers is comprised the following steps：
After Radix Sorghum vulgare Pers are cleaned, dry, pulverize, sieve, obtain Radix Sorghum vulgare Pers powder, the requirement further according to formulation is processed further
Into the antifatigue medicament of Radix Sorghum vulgare Pers of various formulations.
The drying can be using drying, and the temperature of the drying can be 60 DEG C, and the sieving can cross 30 mesh sieves.
Oral liquid need to be such as made, can be by after Radix Sorghum vulgare Pers powder alcohol steep, suction filtration, filtrate concentration, it is quantitative after mistake again
Filter, separates after extraction, and allotment is filling, sterilized, and the antifatigue medicament of Radix Sorghum vulgare Pers of oral liquid formulation is obtained after cooling.
It is 40% alcohol steep that the extraction can use mass percent, and the extraction can be extracted 2 times, and the temperature of extraction can
It it is 70 DEG C, the 1st time of extraction can be 3h, and the time of the 2nd extraction can be 2h；The concentration can use concentrated by rotary evaporation.Institute
Stating allotment can add at least one and water in clover leaching liquor, citric acid, white granulated sugar, vitamin C, potassium sorbate etc. to carry out
Allotment, the crude product after allotment can be filtered through double-layer filter paper；It is described it is canned can first will canned, envelope after deployed beverage crude product preheating
Mouthful.
Other formulations need to be such as made, can be processed by existing common process.
The oxygen radical generation of body caused by excessive body or cerebration increases, and causes the damage of mitochondrial inner membrane
With the decline of function, it is impossible to produce enough ATP to supply and utilize, cell function it is low, under causing the ability to work of body
Drop, fatigue occur.Free radical causes immunologic function disorder, suppresses the hyperplasia differentiation of lymphocyte, suppresses it to stimulating the anti-of original
The function of answering property and cell.The cell subsets such as T, B, NK have different degrees of sensitiveness to free radical；Free radical is for T cell
Inhibitory action be a kind of reversible, the destructive effect of acellular.In the presence of free radical, NK cell killing tumour cells
Function be remarkably decreased.The elimination of free radical and free radical is of close concern to each other with fatigue, (anti-using exogenous free radical scavenger
Oxidation material) free radical is eliminated, interior free yl level is declined the raising with antiradical activities, freedom can be prevented
Infringement of the base to internal eucaryotic cell structure and function, improves the clearance rate of free radical, body is protected, with antifatigue effect.
Antifatigue medicament is constituted based on Radix Sorghum vulgare Pers, containing more flavone compound such as OPC to removing in sorghum
Oxygen radical, with anti-oxidant, free-radical scavenging activity, the raw function of protection cell etc., Radix Sorghum vulgare Pers also have good antioxygen
Change activity.Flavone compound Central nervous system has multiple biological activities, wherein with spirit such as antidepression and antianxieties
Based on regulation activity, its mechanism of action is related to various neurotransmitters and approach.Radix Sorghum vulgare Pers oxidation and removing free radicals, enhancing is immune
Power, the generation of dispelling fatigue and prevention fatigue.
Specific embodiment
Embodiment 1
Prepared by beverage Normal juice, comprise the following steps that：
A certain amount of Radix Sorghum vulgare Pers are weighed, is soaked with pure water, be heated to 100 DEG C, and be allowed to the 20min that seethes with excitement；Repetition fried 2~
3 times, by crude extract low-temperature centrifugation, supernatant is collected, as beverage Normal juice.
Beverage flavor allotment is as follows：
Normal juice has certain bitter taste, in order to improve beverage flavor, mouthfeel and increase the functional components of beverage, according to
Different proportion is diluted with pure water, and adds xylitol (2%~10%, g/mL), the citric acid (0.2% of different quality containing
~0.6%, g/mL) allotment, while addition mass fraction is 1% honey and 0.006% stevioside mixing to improve final wind
Taste.On the basis of single factor experiment, further optimized using orthogonal test, determine the optimal allotment formula of beverage.
Deployed beverage is dispensed into clean beverage bottle, is sealed.Using thermal sterilization mode, sterilization conditions are 127
DEG C, 8min is cooled to 60 DEG C.
Hereinafter give sensory evaluation standard：
Sensory evaluation operating process is:Every standards of grading, color and luster (T1), clarity (T2) to each group formulated drink,
Local flavor (T3), sweet acidity (T4) index carry out sensory evaluation and give a mark.Carried out according to T=0.3T1+0.2T2+0.2T3+0.3T4
Weighting method is scored and takes its average, compares the average value highest for selecting T, and preferable one group of effect is used as optimal allotment ratio.
Embodiment 2
The processing method of decoction is as follows：
3 decoctions of dose point, add water 500ml for the first time, decocts to the concoction of 200ml amounts；Add water 400ml for the second time, decocts
To 150ml；Add water 300ml for the third time, decocts to the concoction of 150ml amounts.
Experimental technique given below：
One, zooperies：By the zoopery of rat, experimental result display we have anti-infective enhance immunity,
Reach antifatigue effect.Every group of each 9 SD male rat (8 week old), is provided by Xiamen University's animal experimental center.It is antifatigue
The composition of medicine is as described above, decocting 3 times, is 100mL by the concentration of 500mL concoctions (per milliliter contained 0.3g).
Experiment one：After rat buys rest in a week, two groups, respectively control group and experimental group are divided into；Implement two
The gavage in week, control group implements physiological saline gavage, and experimental group carries out the gavage of above-mentioned medicine；Daily power of implementing exhausts swimming after gavage
Experiment (method is identical with experiment two).Measure swimming time and be respectively 141.4 ± 32.70 and 239.89 ± 68.41, experiment
The swimming time extension more notable than control group of group, p<0.005 (=0.000124), test result indicate that Radix Sorghum vulgare Pers have oxytolerant, resist
The effect of fatigue.
Experiment two：After rat buys rest in a week, start experiment and be immersed in 5 days in the cage of depth of water 0.22cm, often rat
The water of its replacing cage.Carry out within 6th day random packet and implement gavage and polyinosinic acid intraperitoneal injection, first group of control group reality
Apply gavage and the intraperitoneal injection of physiological saline；Second group of experimental group implements physiological saline gavage and polyinosinic acid intraperitoneal injection
(on 6th, it was 3mg/kg body weight to measure for intraperitoneal injection)；(amount is body to the 3rd group of gavage of experiment dosing group implementation anti-fatigue traditional Chinese
Weight 1%) and polyinosinic acid intraperitoneal injection, one week after implement the gavage of physiological saline and anti-fatigue traditional Chinese respectively daily；
Daily power of implementing exhausts experiment, the suitable lead of every rat tailses negative one its body weight 8%, allows rat in water temperature (25 ± 1 DEG C)
Pond went swimming record rat from enter water swimming time to power and exhaust (head submerged 10s can not emerge as power exhausts) when
Between.Average value and standard error are calculated, with its conspicuousness of t check analyses.Swimming time (unit is s) is compared as follows：The
One group of swimming time 148.59 ± 39.95；Second group of swimming time 144.30 ± 37.20；3rd group of power exhausts trip
The swimming time 156.16 ± 42.32.Second group of swimming time is shortened than first group, but without significant difference；Exhausted from power
Compare on swimming time, the 3rd group of swimming time increases and without significant difference than first group, and the 3rd group of swimming time
(p is significantly increased compared with second group<0.005).Show that there is Radix Sorghum vulgare Pers anti-infective raising immunocompetence to reach elimination tired
The effect of labor, it is compound to the immune related fatigue for causing to treat.
Clinical example given below：
1. Wei, man, grow up, symptoms include limbs lassitude hypodynamia, and lazy Yan , Satisfied are few, and dynamic then shortness of breath, greasy fur on tongue, veins is sliding gives
Medicine adds and subtracts 3 doses of decoctions, symptom mitigation.
2. Wu, man, grow up, limbs lassitude hypodynamia 2~3 days, and four limbs lassitude hypodynamia, backache, lazy move is received and subtracted, voluminous sweat
Go out, arteries and veins moistens, add sanction to give 3 doses of Chinese medicine decoctions, symptom mitigation to add medicine to.
3. Lin, man, grow up, and tired 4 days, four limbs lassitude hypodynamia, lazy move, brothers were tingle, loss of appetite, pale tongue with greasy fur, arteries and veins
Powerless, plan top plus-minus gives 3 doses and is decocted in water for oral dose, symptom mitigation.
4. Chen, female, adult, limbs lassitude hypodynamia, four limbs lassitude hypodynamia, refreshing tired, loss of appetite, cough, and foul wind likes clothing,
Drowsiness, pale tongue with greasy fur, arteries and veins is powerless, gives 3 doses of medicine-feeding plus-minus and is decocted in water for oral dose, symptom mitigation.
5. Lu, female, grow up, tired weary 5 days, limbs fatigue, burnout, and thermophilic sleeping, Muscular stiffness is nose heave, and food subtracts, and gastral cavilty is swollen
Full, tongue is greasy, and arteries and veins moistens, with plus-minus of adding medicine to being taken after 3 doses of decoctings, symptom mitigation.
6. Zhang, man, adult, four limbs lassitude hypodynamia, deficiency of QI with disinclination to talk, god is tired, drowsiness, and work pale tongue with greasy fur, wiry and rolling pulse without
Power, gives 2 doses and is decocted in water for oral dose with top plus-minus, symptom mitigation.
7. Feng, man, grow up, limbs lassitude hypodynamia, and few gas, lusterless complexion is numb in every limb, and food subtracts, tastelessness, tongue is weak
Tongue is greasy, and arteries and veins moistens, and medicine-feeding plus-minus is decocted in water for oral dose to 3 doses of Chinese medicines, and symptom subtracts greatly.
8. Lin, man, grow up, refreshing tired, lassitude hypodynamia, body weight, and knee joint soreness is nose heave, and pale tongue with greasy fur, arteries and veins is powerless, gives
State 3 doses of medicine to be decocted in water for oral dose, symptom mitigation.
9. flood certain, female, adult, refreshing tired body is tired, limbs fatigue, pale complexion, and few gas, pale tongue with greasy fur, arteries and veins is powerless, medicine-feeding plus
Sanction gives 3 doses to be decocted in water for oral dose, symptom mitigation.
10. what certain, man, adult, body is tired, and limbs fatigue, body weight, distraction, chest distress, tongue thickness is greasy, and arteries and veins moistens, and intends
Medicine-feeding plus-minus is taken after giving 3 doses of decoctings, symptom mitigation.
11. Qiu, man, adult, fatigue in both spirit and physical strength, refreshing tired, palpitaition, few gas lazy move, without appetite, pale tongue with white fur, arteries and veins is thin.More than
Medicine adds sanction to give 3 doses to be decocted in water for oral dose, and symptom subtracts greatly.
12. Lins, man, adult, lassitude hypodynamia, bitterly, foul wind, phlegm is white, receives and subtracts for Zhi Ti Acid, and tongue fur is white, and veins is sliding is powerless, the above
Component plus-minus gives 3 doses of doses, is decocted in water for oral dose, symptom mitigation.
13. Lins, man, adult, four limbs lassitude hypodynamia, nose heave, food subtracts, Zhi Ti Acid Chu, drowsiness, Xi Jing Acid bitterly, tongue is weak tongue
Thick greasy, arteries and veins moistens, and intends medicine-feeding plus sanction gives 3 doses to be decocted in water for oral dose, symptom mitigation.
14. Lins, female, adult, four limbs lassitude hypodynamia, god is tired, headache, and tongue side point is red, tongue is thin, deep,thready and forceless pulse, in plan
Side's plus-minus gives 3 doses and is decocted in water for oral dose, symptom mitigation.
15. Lins, female, adult, four limbs lassitude hypodynamia, drowsiness, appetite subtracts, and voluminous foul wind, body weight, tongue is greasy, and arteries and veins moistens.More than
To state carry out plus-minus based on medicine and give 3 doses and be decocted in water for oral dose, symptom mitigation.
16. Wang, man, adult, refreshing tired, limbs fatigue, deficiency of QI with disinclination to talk, body weight, lower limb slightly swell, oliguresis, pale tongue with greasy fur, arteries and veins
String.3 dosage are given to be decocted in water for oral dose with plus-minus of adding medicine to, symptom subtracts greatly.
17. Huangs, female, adult, the tired a few days, four limbs lassitude hypodynamia, god it is tired, it is drowsiness, especially with menstrual period aggravate, complexion without
China, tongue is weak, arteries and veins is thin, intends medicine-feeding plus-minus and gives 3 doses of symptom mitigations that are decocted in water for oral dose.
18. Soviet Unions certain, man, adult, refreshing tired, four limbs lassitude hypodynamia, voluminous foul wind, palpitaition, few gas, tooth print tongue is thin white, arteries and veins without
Power, intends plus-minus based on medicine-feeding and gives 3 doses and be decocted in water for oral dose, symptom mitigation.
19. Hus, man, adult, tired 5 days, four limbs lassitude hypodynamia, drowsiness, body weight, refreshing tired, lower limb were miserable, oliguria, tongue
Light tongue is greasy, arteries and veins is thin.Added and subtracted based on top and be decocted in water for oral dose with 5 doses, symptom subtracts greatly.
20. Chens, female, adult, weary, lassitude hypodynamia, body weight, nose heave, oliguria, tongue is greasy, and arteries and veins moistens, and is given with this side plus-minus
3 doses are decocted in water for oral dose, symptom mitigation.
Claims (10)
1. the antifatigue medicament of a kind of Radix Sorghum vulgare Pers, it is characterised in that its raw material is Radix Sorghum vulgare Pers；The raw material may also include auxiliary material, described
Auxiliary material is included but is not limited in clover leaching liquor, citric acid, white granulated sugar, vitamin C, potassium sorbate, honey, stevioside extremely
Few one kind.
2. as claimed in claim 1 a kind of antifatigue medicament of Radix Sorghum vulgare Pers, it is characterised in that the agent of the antifatigue medicament of Radix Sorghum vulgare Pers
Type is the one kind in decoction, oral liquid, granule, tablet, pill, paste formulation.
3. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers, its spy is characterised by comprising the following steps：
After Radix Sorghum vulgare Pers are cleaned, dry, pulverize, sieve, obtain Radix Sorghum vulgare Pers powder, the requirement further according to formulation is further processed into respectively
Plant the antifatigue medicament of Radix Sorghum vulgare Pers of formulation.
4. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 3, its spy is characterised by that the drying is using drying
Dry, the temperature of the drying is 60 DEG C.
5. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 3, its spy is characterised by that the sieving was 30 mesh
Sieve.
6. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 2, its spy is characterised by the preparation of the oral liquid
Method is as follows：After Radix Sorghum vulgare Pers powder alcohol steep, suction filtration, filtrate concentration is filtered again after quantifying, and is separated after extraction, is adjusted
Match somebody with somebody, it is filling, it is sterilized, the antifatigue medicament of Radix Sorghum vulgare Pers of oral liquid formulation is obtained after cooling.
7. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 6, its spy is characterised by that the extraction uses quality
Percentage is 40% alcohol steep, and the extraction is extraction 2 times, and the temperature of extraction is 70 DEG C, and the 1st time of extraction is 3h,
2nd time of extraction is 2h.
8. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 6, its spy is characterised by the concentration using revolving
Concentration.
9. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 6, its spy is characterised by that the allotment is addition three
At least one and water in leaf grass leaching liquor, citric acid, white granulated sugar, vitamin C, potassium sorbate are allocated, thick after allotment
Product are filtered through double-layer filter paper.
10. the preparation method of the antifatigue medicament of Radix Sorghum vulgare Pers as claimed in claim 6, its spy be characterised by it is described it is canned be that will first adjust
Canned, sealing after the beverage crude product preheating for preparing.
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|---|---|---|---|
| CN201611256767.6A CN106729095A (en) | 2016-12-30 | 2016-12-30 | A kind of antifatigue medicament of Radix Sorghum vulgare Pers and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611256767.6A CN106729095A (en) | 2016-12-30 | 2016-12-30 | A kind of antifatigue medicament of Radix Sorghum vulgare Pers and preparation method thereof |
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| CN106729095A true CN106729095A (en) | 2017-05-31 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156637A (en) * | 2007-11-15 | 2008-04-09 | 陈国荣 | A tea for warming, cold-resist, anti-fatigue and warming-up stomach as well as preparing method |
| CN102600390A (en) * | 2012-04-10 | 2012-07-25 | 华中农业大学 | Sorghum root extract and preparation method and application thereof |
-
2016
- 2016-12-30 CN CN201611256767.6A patent/CN106729095A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156637A (en) * | 2007-11-15 | 2008-04-09 | 陈国荣 | A tea for warming, cold-resist, anti-fatigue and warming-up stomach as well as preparing method |
| CN102600390A (en) * | 2012-04-10 | 2012-07-25 | 华中农业大学 | Sorghum root extract and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 温梦霞: "《传世中医秘方》", 31 July 2015, 福建科学技术出版社 * |
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Application publication date: 20170531 |
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