CN106728976A - A kind of composition for preventing and treating hemorrhagic disease of grass carp - Google Patents

A kind of composition for preventing and treating hemorrhagic disease of grass carp Download PDF

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Publication number
CN106728976A
CN106728976A CN201710126206.2A CN201710126206A CN106728976A CN 106728976 A CN106728976 A CN 106728976A CN 201710126206 A CN201710126206 A CN 201710126206A CN 106728976 A CN106728976 A CN 106728976A
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parts
grass carp
hemorrhagic disease
preventing
composition
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苏金武
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Changsha Ruiduokang Biotechnology Co Ltd
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Changsha Ruiduokang Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia

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Abstract

The present invention relates to a kind of composition for preventing and treating hemorrhagic disease of grass carp, it is characterised in that be made up of the raw material of following weight portion:5~8 parts of bletilla, 10~15 parts of moutan bark, 5~8 parts of the root of large-flowered skullcap, 6~10 parts of mulberry leaf, 15~20 parts of Radix Isatidis, 3~6 parts of Chinese gall, 6~10 parts of Asian puccoon, 12~18 parts of rhizoma gastrodiae, 2~5 parts of radix bupleuri, 5~8 parts of manyflower glorybower root, 6~10 parts of Radix Glycyrrhizae.The present invention has preferable antivirus action, and energy effectively preventing hemorrhagic disease of grass carp is reduced because hemorrhagic disease of grass carp is dead, had no toxic side effect and medicament residue, and production cost is relatively low, easy to use.

Description

A kind of composition for preventing and treating hemorrhagic disease of grass carp
Technical field
The present invention is related to the disease treatment of the grass carp in aquaculture, and in particular to a kind of group for preventing and treating hemorrhagic disease of grass carp Compound.
Background technology
Hemorrhagic disease of grass carp is that a kind of Prevalent district is extensive, epidemic season is long, the incidence of disease is high, the death rate is high, harmfulness is big Fish disease caused by virus.The pathogen of this disease is Aquareovirus, is subordinate to Reoviridae, Aquareovirus Category, 70 ~ 80nm of diameter, 20 face body spheric granules contain 11 double-stranded RNAs of fragment.There are different strains in different regions.Should Viral mainly to cause CHINESE FRESHWATER to cultivate principal item grass carp in fingerling stage generation hemorrhage, its result often results in large quantities of Amount Grass Carp Juveniles or adult fish are dead.Water temperature is the most popular in more than 25-28%, and 8-9 months are epidemic peak, and the disease can lead to Crossing contaminated water, food etc. carries out horizontal transmission, also can carry out vertical transmission by ovum.The sick death rate is up to more than 85%, Brought about great losses to culture fishery.
The content of the invention
It is an object of the invention to overcome shortcoming present in prior art, there is provided a kind of reasonable recipe, prepare it is simple, A kind of composition of preventing and treating hemorrhagic disease of grass carp easy to use.
The composition of described a kind of preventing and treating hemorrhagic disease of grass carp, it is characterised in that be made up of the raw material of following weight portion:Bletilla 5~ 8 parts, 10~15 parts of moutan bark, 5~8 parts of the root of large-flowered skullcap, 6~10 parts of mulberry leaf, 15~20 parts of Radix Isatidis, 3~6 parts of Chinese gall, Asian puccoon 6~ 10 parts, 12~18 parts of rhizoma gastrodiae, 2~5 parts of radix bupleuri, 5~8 parts of manyflower glorybower root, 6~10 parts of Radix Glycyrrhizae.
A kind of preparation method of the composition of above-mentioned preventing and treating hemorrhagic disease of grass carp is:Each original is weighed by described weight portion Material, by the sum-rate 1 of bulk drug:10 add water, and soak 40 minutes, and conventionally decoct twice, and filtering merges twice Filtrate obtains final product composition.
The application method of a kind of composition for preventing and treating hemorrhagic disease of grass carp, it is characterised in that by liquid full pool spilling head, sprinkle The amount of spilling is 3~5ppm.
A kind of above-mentioned composition material effect parsing for preventing and treating hemorrhagic disease of grass carp:
Bletilla:Astringing to arrest bleeding, detumescence and promoting granulation, control traumatism and bleeding, sore swollen toxin, chapped skin;
Moutan bark:It is clearing heat and cooling blood, promoting blood circulation and removing blood stasis, control febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, Carbuncle sore tumefacting virus, injuries from falls as well;
The root of large-flowered skullcap:It is heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, there is wider antimicrobial spectrum, in vitro test has suppression to bacillus, coccus Make and use, infected by influenza, dermatophyte also have effect;
Mulberry leaf:Dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clear liver and improve vision, there is antibacterial, diuresis, step-down etc. to act on;
Radix Isatidis:Clearing heat and detoxicating, cool blood relieving sore-throat.Make with antibacterium, virus, antiendotoxin, anticancer, enhancing immunological regulation etc. With;
Chinese gall:To staphylococcus aureus, beta hemolytic streptococcus, pneumococcus, Pseudomonas aeruginosa, shigella dysenteriae, anthrax Bacillus, corynebacterium diphtheriae, Escherichia coli, Typhoid and paratyphoid bacillus etc. have obvious antibacterial and bactericidal action;
Asian puccoon:With the effect such as anti-inflammatory, antipyretic, calm, analgesia, resisting pathogenic microbes, antitumor, antifertility, excited smooth;
Rhizoma gastrodiae:QI invigorating power, nourishing and strengthening vital is made light of one's life by commiting suicide increasing year, subduing inflammation, lower extremity swelling and distension, blood under cold hernia;
Radix bupleuri:With anti-inflammatory, antipyretic, calm, analgesia, antibechic and anticonvulsant action;It is antiulcer, antibacterial, antiviral;
Manyflower glorybower root:The clear spot of clearing heat and detoxicating, cool blood.The heat-clearing and detoxifying drug classified under category antipyretic;
Radix Glycyrrhizae:Anti-inflammatory, antiulcer, antianaphylaxis, anticancer, antibacterial are antiviral, promote pancreatic secretion, have suppression in vitro intestines, Regulation immunologic function.
Beneficial effect:
1st, energy effectively preventing hemorrhagic disease of grass carp, reduces because hemorrhagic disease of grass carp is dead;
2nd, using the cooperation of Chinese herbal medicine formula, it is not likely to produce the resistance to the action of a drug;
3rd, many advantages, such as lacking with safe, residual.
Specific embodiment:
Embodiment one:
The composition of described a kind of preventing and treating hemorrhagic disease of grass carp, it is characterised in that be made up of the raw material of following weight portion:Bletilla 6 Part, 14 parts of moutan bark, 8 parts of the root of large-flowered skullcap, 8 parts of mulberry leaf, 18 parts of Radix Isatidis, 3 parts of Chinese gall, 7 parts of Asian puccoon, 18 parts of rhizoma gastrodiae, 4 parts of radix bupleuri, 5 parts of manyflower glorybower root, 9 parts of Radix Glycyrrhizae.
Embodiment two:
The composition of described a kind of preventing and treating hemorrhagic disease of grass carp, it is characterised in that be made up of the raw material of following weight portion:Bletilla 7 Part, 13 parts of moutan bark, 7 parts of the root of large-flowered skullcap, 9 parts of mulberry leaf, 19 parts of Radix Isatidis, 5 parts of Chinese gall, 8 parts of Asian puccoon, 15 parts of rhizoma gastrodiae, 3 parts of radix bupleuri, 6 parts of manyflower glorybower root, 8 parts of Radix Glycyrrhizae.
Embodiment three:
The composition of described a kind of preventing and treating hemorrhagic disease of grass carp, it is characterised in that be made up of the raw material of following weight portion:Bletilla 8 Part, 12 parts of moutan bark, 6 parts of the root of large-flowered skullcap, 10 parts of mulberry leaf, 20 parts of Radix Isatidis, 4 parts of Chinese gall, 9 parts of Asian puccoon, 12 parts of rhizoma gastrodiae, 5 parts of radix bupleuri, 7 parts of manyflower glorybower root, 7 parts of Radix Glycyrrhizae.
A kind of preparation method of the composition of preventing and treating hemorrhagic disease of grass carp of examples detailed above is:Weighed respectively by described weight portion Raw material, by the sum-rate 1 of raw material:10 add water, and soak 40 minutes, and conventionally decoct twice, and filtering merges twice Filtrate obtains final product.
The composition application method of described a kind of preventing and treating hemorrhagic disease of grass carp, it is characterised in that sprinkle the full pond of composition liquid Spill, the amount of splashing is 3~5ppm.
Experiment effect of the invention
The hemorrhagic disease of grass carp disease tail of fish 600 is taken, every group of 150 tails, point four ponds are placed, and the tail of disease fish 150, water depth are put into per pond 1.5 meters, control 25 DEG C or so of water temperature.Blank group routine feeding, experimental group 1 uses embodiments of the invention one, and experimental group 2 is used Embodiments of the invention two, experimental group 3 uses embodiments of the invention three, experimental group by the present composition by the full pond of liquid Splash, the amount of splashing is 5ppm.The data such as following table of record grass carp after 10 days:
Blank group Experimental group 1 Experimental group 2 Experimental group 3
Hemorrhage grass carp number 150 150 150 150
Survival number 58 142 138 136
Survival rate 38.7% 94.7% 92.0% 90.7%
The present invention has good curative effect to hemorrhagic disease of grass carp as can be seen from the above table.
The above, is only presently preferred embodiments of the present invention, is not the limitation for making other forms to the present invention, is appointed What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc. Effect embodiment.But it is every without departing from technical solution of the present invention content, according to technical spirit of the invention to above example institute Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.

Claims (1)

1. it is a kind of prevent and treat hemorrhagic disease of grass carp composition, it is characterised in that be made up of the raw material of following weight portion:5~8 parts of bletilla, 10~15 parts of moutan bark, 5~8 parts of the root of large-flowered skullcap, 6~10 parts of mulberry leaf, 15~20 parts of Radix Isatidis, 3~6 parts of Chinese gall, Asian puccoon 6~10 Part, 12~18 parts of rhizoma gastrodiae, 2~5 parts of radix bupleuri, 5~8 parts of manyflower glorybower root, 6~10 parts of Radix Glycyrrhizae.
CN201710126206.2A 2017-03-06 2017-03-06 A kind of composition for preventing and treating hemorrhagic disease of grass carp Withdrawn CN106728976A (en)

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CN201710126206.2A CN106728976A (en) 2017-03-06 2017-03-06 A kind of composition for preventing and treating hemorrhagic disease of grass carp

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107549065A (en) * 2017-10-27 2018-01-09 汉寿县武华淡水生态养殖有限公司 A kind of method for improving high-density breeding fish survival rate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961414A (en) * 2010-06-23 2011-02-02 天津生机集团股份有限公司 Medicament for preventing and curing grass carp bleeding disease
CN103055207A (en) * 2012-12-04 2013-04-24 青岛绿曼生物工程有限公司 Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961414A (en) * 2010-06-23 2011-02-02 天津生机集团股份有限公司 Medicament for preventing and curing grass carp bleeding disease
CN103055207A (en) * 2012-12-04 2013-04-24 青岛绿曼生物工程有限公司 Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107549065A (en) * 2017-10-27 2018-01-09 汉寿县武华淡水生态养殖有限公司 A kind of method for improving high-density breeding fish survival rate

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