CN106728413A - A kind of Chinese medicine composition and preparation method for improving severe ox immunity - Google Patents
A kind of Chinese medicine composition and preparation method for improving severe ox immunity Download PDFInfo
- Publication number
- CN106728413A CN106728413A CN201611262522.4A CN201611262522A CN106728413A CN 106728413 A CN106728413 A CN 106728413A CN 201611262522 A CN201611262522 A CN 201611262522A CN 106728413 A CN106728413 A CN 106728413A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- immunity
- severe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to technical field of traditional Chinese medicines, especially it is a kind of improve severe ox immunity Chinese medicine composition and preparation method, it is made with golden flower tea extractions, barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos by raw material, the Chinese medicine composition can significantly improve the immunocompetence of ox, and with antineoplastic action, its drug effect is notable, toxicity is low, consumption is small.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, especially a kind of Chinese medicine composition for improving severe ox immunity and preparation side
Method.
Background technology
Due to the influence of environmental factor, the weaker ox of some immunocompetences is easily caused various illnesss, can also draw when serious
Play death；For example in spring or summer, ox is subject to strong periods of direct sunlight because of head, it may appear that spiritual depressed, weakness of limbs, sternly
Cause CNS disorders or paralysis, violent spasm or tic when weight, it is rapid dead；And in autumn and winter, cold wet gas
Under time makes ox jaw, belly and perineum both sides rubefaction, there is the hard lesser tubercle such as broad bean size, itching is uneasy, with the state of an illness
Development, whole body coat loss is local rotten to the corn or suppurate, and infected cattle is gradually become thin, and has a delicate constitution and dead；Therefore how ox is strengthened
Immunity, this has turned into one very important problem of aquaculture；The ox of seriously disease is particularly suffered from, except treatment disease
Outward, in addition it is also necessary to booster immunization power, so as to improve chances of survival.
At present, the immunity of medicine raising ox of the prior art is deficienter, and majority improves immune in the way of dietotherapy
Power, time-consuming, DeGrain；For this present invention provides a kind of Chinese medicine composition for improving severe ox immunity, the Chinese medicine group
Compound can improve the immunity of body, suppress tumour growth, and therapeutic effect is better than existing medicine.
The content of the invention
In order to solve the above-mentioned technical problem, the present invention provide it is a kind of improve severe ox immunity Chinese medicine composition, be by
The raw material composition of following weight portion：
40~70 parts of golden flower tea extractions, 35~60 parts of barrenwort, 30~55 parts of the fruit of glossy privet, 30~50 parts of the Radix Astragali, Radix Codonopsis
20~40 parts, 20~40 parts of the bighead atractylodes rhizome, 20~40 parts of matrimony vine, 20~40 parts of Poria cocos；
Preferred raw material is in parts by weight：50~60 parts of golden flower tea extractions, 40~50 parts of barrenwort, the fruit of glossy privet 35~
50 parts, 35~45 parts of the Radix Astragali, 25~35 parts of Radix Codonopsis, 30~40 parts of matrimony vine, 30~40 parts of Poria cocos；
Preferred raw material is in parts by weight：55 parts of golden flower tea extractions, 50 parts of barrenwort, 45 parts of the fruit of glossy privet, the Radix Astragali
40 parts, 30 parts of Radix Codonopsis, 30 parts of matrimony vine, 30 parts of Poria cocos.
Preparation method is as follows：
Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add 6~10 times of medicines
The water of material amount, is decocted 2~5 hours, and filtrate is taken out in filtering, and the dregs of a decoction add cold water decocting, 3 times repeatedly, merge liquid, staticly settle medicine
Liquid 1~3 hour, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration
To 20~60 DEG C of temperature, relative density 1.2~1.3 obtains thick paste, spray-dried to obtain finished product.
Wherein described Chinese medicine composition also includes the bighead atractylodes rhizome and Sculellaria barbata.
The wherein described bighead atractylodes rhizome is 20~40 parts, Sculellaria barbata is 20~40 parts.
After the wherein described bighead atractylodes rhizome uses temperature for 30~50 DEG C of 1~3min of drying and processing, insert in vapor steam 10~
Used after 20min；Dry and cause that its dry property is relaxed, section becomes simple and easy to apply, and enhances the effect of invigorating the spleen, stomach invigorating；
Rational water steams the time so that the harder bighead atractylodes rhizome of script quality is effectively softened, this and traditional water treating softener mode,
The loss of active ingredient is reduced, while also have increasing lactone content, the property of medicine is relaxed, part carbohydrate hydrolysis is easily absorbed.
Wherein described Sculellaria barbata by with potassium dihydrogen phosphate according to mass ratio be 1:After 0.01~0.07 mixing, in temperature
To be fermented at 35~46 DEG C, process 5~7 days so that the cellulase pectase produced in fermentation process can destroy corn stigma
Plant cell wall, active ingredient is exposed, into vivo after, no longer influenceed because of the resistance of cell membrane absorb,
Various macromolecular substances such as tannin, pectin, mucilaginous substance and floccule are removed simultaneously, improve the utilization rate of effective ingredient.
Wherein described spray drying, spray tower air themperature is 140~160 DEG C, goes out tower air themperature 80~100
DEG C, the free water content of most output aggregate, the too low product free water that can be caused after spraying of temperature are influenceed due to spray drying temperature
Excessively, it is slurry material, temperature is too high to cause Disassembling Products to go bad, the rational control temperature of the present invention, in obtaining high-quality
Drug composition.
Camellia nitidissima is the evergreen shrubs or dungarunga of Theaceae Camellia, and its flower and leaf are Zhuang nationality in Guangxi tradition use among the people
Medicine, is pure day also containing trace elements such as selenium, zinc, germanium, alum containing the various active composition such as Tea Polyphenols, tea saponin, flavonoids
Right rare health treasure, with hypoglycemic, drop cholesterol in serum, suppresses tumour growth, improves immunity of organisms etc. various
Physiological function, the present invention wants raw material using based on golden flower tea extractions, and extracting method is as follows：Camellia nitidissima is broken through high-speed organization respectively
After broken machine is crushed, pectase is added, be heated to 35~40 DEG C, and be stirred continuously, constant temperature keeps 1~2h, treats pectinase treatment knot
Shu Hou, being heated rapidly to 100 DEG C carries out destroy the enzyme treatment, and 20% alcohol-water mixing leaching is added when temperature is down to 60~70 DEG C
Extract, input ultrasonic processor is shaken, and through filtering, residue adds the pure water to carry out second ultrasonication, merges twice
Filtrate, concentration, constant volume obtain final product extract.
Beneficial effect of the present invention：
The present invention uses golden flower tea extractions, barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos for raw material is prepared
Into Chinese medicine composition, wherein with Camellia nitidissima as monarch drug in a prescription, using ultrasonic wave extraction golden flower camellias, the active ingredient of Ye Hegen, phase
Than that in the mode of traditional decoction, can significantly improve drug effect, because Camellia nitidissima contains abundant slack skin element, it has significantly cell toxicant
Effect and antitumor activity, inducing apoptosis of tumour cell；The bighead atractylodes rhizome of addition and Sculellaria barbata have antitumor action, but both share
Than alone any one drug effect significantly, drugs against tumor ability of the present invention is further strengthened；The Radix Astragali in said composition, Radix Codonopsis, matrimony vine,
The addition of Poria cocos, enhancing medicine is improved to the immunocompetence of body, so as to improve the constitution of ox, resistance against diseases is effectively carried
Height, environment-adapting ability is strengthened to external world, and increases the chances of survival of the ox with severe；Medicine of the present invention by grinding repeatedly
Study carefully, raw material are selected by rational, and it is reasonably combined, it is allowed to possess the characteristics of drug effect is notable, toxicity is low, consumption is small.
Specific embodiment
Embodiment 1
Formula：Golden flower tea extractions 60g, barrenwort 50g, fruit of glossy privet 50g, Radix Astragali 45g, Radix Codonopsis 35g, matrimony vine 40g, Poria cocos
40g；
Preparation method：Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add
10 times of water of medicinal material amount, are decocted 3 hours, and filtrate is taken out in filtering, and the dregs of a decoction add cold water decocting, 3 times repeatedly, merge liquid, and it is heavy to stand
Shallow lake liquid 3 hours, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration
To 55~60 DEG C of temperature, relative density 1.2~1.3 obtains thick paste, spray-dried, and spray tower air themperature is 155~160
DEG C, go out 95~100 DEG C of tower air themperature, get product.
Embodiment 2
Formula：Golden flower tea extractions 50g, barrenwort 40g, 35 parts of the fruit of glossy privet, the Radix Astragali 35, Radix Codonopsis 25g, matrimony vine 30g, Poria cocos
30g；
Preparation method：Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add 6
The water of times medicinal material amount, is decocted 1 hour, and filtrate is taken out in filtering, and the dregs of a decoction add cold water decocting, 3 times repeatedly, merge liquid, staticly settle
Liquid 1 hour, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration is extremely
20~25 DEG C of temperature, relative density 1.2~1.3 obtains thick paste, spray-dried, and spray tower air themperature is 140~145 DEG C,
Go out 80~85 DEG C of tower air themperature, get product.
Embodiment 3
Formula：Golden flower tea extractions 55g, barrenwort 50g, fruit of glossy privet 45g, Radix Astragali 40g, Radix Codonopsis 30g, matrimony vine 30g, Poria cocos
30g；
Preparation method：
Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add 8 times of medicinal material amounts
Water, decoct 2 hours, filtering take out filtrate, the dregs of a decoction add cold water decoct, 3 times repeatedly, merge liquid, staticly settle liquid 2 small
When, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration to temperature 40
~45 DEG C, relative density 1.2~1.3 obtains thick paste, spray-dried, and spray tower air themperature is 150~155 DEG C, goes out tower empty
85~90 DEG C of temperature degree, gets product.
Embodiment 4
Formula：Golden flower tea extractions 52g, barrenwort 45g, fruit of glossy privet 40g, Radix Astragali 38g, Radix Codonopsis 32g, matrimony vine 37g, Poria cocos
38g；
Preparation method：
Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add 7 times of medicinal material amounts
Water, decoct 90min, filtering take out filtrate, the dregs of a decoction add cold water decoct, 3 times repeatedly, merge liquid, staticly settle liquid
150min, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration to temperature
30~35 DEG C of degree, relative density 1.2~1.3 obtains thick paste, and spray-dried spray tower air themperature is 145~150 DEG C, is gone out
90~95 DEG C of tower air themperature, gets product.
Embodiment 5
Formula：Golden flower tea extractions 58g, barrenwort 42g, fruit of glossy privet 45g, Radix Astragali 43g, Radix Codonopsis 33g, matrimony vine 37g, Poria cocos
34g；
Preparation method；
Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add 9 times of medicinal material amounts
Water, decoct 150min, filtering take out filtrate, the dregs of a decoction add cold water decoct, 3 times repeatedly, merge liquid, staticly settle liquid
90min, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration to temperature
50~55 DEG C, relative density 1.2~1.3 obtains thick paste, spray-dried, and spray tower air themperature is 155~160 DEG C, goes out tower
80~85 DEG C of air themperature, gets product.
Embodiment 6
Formula：Golden flower tea extractions 60g, barrenwort 48g, fruit of glossy privet 38g, Radix Astragali 35g, Radix Codonopsis 25g, matrimony vine 30g, Poria cocos
35g；
Preparation method：
Barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, is soaked 12 hours；Add 8 times of medicinal material amounts
Water, decoct 100min, filtering take out filtrate, the dregs of a decoction add cold water decoct, 3 times repeatedly, merge liquid, staticly settle liquid
170min, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration to temperature
40~45 DEG C of degree, relative density 1.2~1.3 obtains thick paste, spray-dried, and spray tower air themperature is 140~145 DEG C, is gone out
95~100 DEG C of tower air themperature, gets product.
Embodiment 7
Formula：Golden flower tea extractions 50g, barrenwort 40g, fruit of glossy privet 50g, Radix Astragali 35g, 25~35g of Radix Codonopsis, matrimony vine 32g,
Poria cocos 32g, bighead atractylodes rhizome 35g, Sculellaria barbata 35g；
Preparation method：
By barrenwort, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, clean, soak 12 hours；Place into processed white
Art and Sculellaria barbata, add 7 times of water of medicinal material amount, decoct 90min hour, and filtrate is taken out in filtering, and the dregs of a decoction add cold water pan-fried, and repeatedly 3
It is secondary, merge liquid, staticly settle liquid 90min, then with 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding gold
Jasmine tea extract, freeze concentration to 45~50 DEG C of temperature, relative density 1.2~1.3 obtains thick paste, spray-dried, spray tower
Air themperature is 145~150 DEG C, goes out 90~95 DEG C of tower air themperature, is got product.
Test example 1
Clinical test totally 240, is divided into 8 groups, every group of random 30 ox, male and female half and half, embodiment group daily this hair
Bright medicine, blank group refuses to obey medicine, after 30 days, carries out venous blood collection, and centrifugation prepares serum, and checks；Result of the test shows clothes
Medicine of the present invention is used, total protein, albumin, the content of IgA, IgG, IgM in ox body can be significantly improved, strengthen the immune of ox
Ability, reduces the content of internal glutamic-oxalacetic transaminease, so that the occurrence probability of disease is reduced, and wherein the effect of embodiment 3 shows the most
Write, albumin, IgA, IgG content are higher than embodiment 3 in embodiment 7, this is relevant with the bighead atractylodes rhizome of addition and Sculellaria barbata, further carries
Immunocompetence high.
Test example 2
Chronic toxicity test：
Experimental group：Group 1 takes small white mouse 10, and body weight 20g or so, male and female half and half are filled per daily drug dilution liquid of the present invention
Stomach, dosage：200mg/kg；Group 2 takes small white mouse 10, body weight 20g or so, male and female half and half, per daily drug dilution liquid of the present invention
Gavage, dosage：400mg/kg；Group 3 small white mouse 10, body weight 40g or so, male and female half and half, per daily drug dilution liquid of the present invention
Gavage, dosage：700mg/kg；Every group of continuous gavage 30 days, observes after being discontinued 14 days.
Control group：The 9g/L physiological saline of daily gavage equivalent.Continuous gavage 30 days, observes after being discontinued 14 days.
The mouse of 30 days processes of experiment, clinical observation test group and control group, the state of mind, diet, drinking-water, urination, defecation
And respond is showed no obvious abnormalities to external world, after being discontinued 14 days, mouse is catched and killed, collection blood separates serum, surveys
Determine the content of serum alt and AST, compared with control group, difference is not notable, all in normal range (NR).
After being discontinued 14 days, by cut open inspection, each group small white mouse heart, liver, spleen, lung, the form of kidney, color are normal, without substantially
Between naked eyes lesions visible, each group the heart of small white mouse, liver, spleen, lungs, Kidney coefficients difference not significantly, in illustrating this
Drug composition will not cause animal Solid organ injury or ANOMALOUS VARIATIONS.
By above testing and verification, the blood routine and organ coefficient of mouse, without significant difference, illustrate this hair with control group
Bright Chinese medicine composition will not produce chronic toxic action to small white mouse.
Acute toxicity test：
It is 40 small white mouses of 20g or so, male and female half and half, using drug dilution liquid gavage of the present invention, gavage to use body weight
Amount presses 0.5ml/10g, and the median lethal dose of Chinese medicine composition of the present invention can not be measured through prerun.Observation two weeks, the experiment of mouse
Activity is normal, and none mouse is dead, therefore drug oral toxicity very little of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for improving severe ox immunity, it is characterised in that its material composition is in parts by weight：Golden flower
40~70 parts of tea extraction, 35~60 parts of barrenwort, 30~55 parts of the fruit of glossy privet, 30~50 parts of the Radix Astragali, 20~40 parts of Radix Codonopsis, matrimony vine
20~40 parts, 20~40 parts of Poria cocos.
2. as claimed in claim 1 improve severe ox immunity Chinese medicine composition, it is characterised in that described material composition with
Weight portion is calculated as：50~60 parts of golden flower tea extractions, 40~50 parts of barrenwort, 35~50 parts of the fruit of glossy privet, 35~45 parts of the Radix Astragali, party
25~35 parts of ginseng, 30~40 parts of matrimony vine, 30~40 parts of Poria cocos.
3. as claimed in claim 1 improve severe ox immunity Chinese medicine composition, it is characterised in that described material composition with
Weight portion is calculated as：55 parts of golden flower tea extractions, 50 parts of barrenwort, 45 parts of the fruit of glossy privet, 40 parts of the Radix Astragali, 30 parts of Radix Codonopsis, 30 parts of matrimony vine,
30 parts of Poria cocos.
4. the Chinese medicine composition of severe ox immunity is improved as claimed in claim 1, it is characterised in that the Chinese medicine composition is also
Including the bighead atractylodes rhizome and Sculellaria barbata.
5. the Chinese medicine composition of severe ox immunity is improved as claimed in claim 1, it is characterised in that preparation method is：Will be excessive
The sheep leaves of pulse plants, the fruit of glossy privet, the Radix Astragali, Radix Codonopsis, matrimony vine, Poria cocos are cleaned, and are soaked 12 hours；6~10 times of water of medicinal material amount are added, is decocted
1~3 hour, filtrate was taken out in filtering, and the dregs of a decoction add cold water decocting, 3 times repeatedly, merge liquid, staticly settle liquid 1~3 hour, then
With 4 layers of filtered through gauze 3 times；Liquid is pumped into concentration tank, while adding golden flower tea extractions, freeze concentration to temperature 20~60
DEG C, relative density 1.2~1.3 obtains thick paste, spray-dried to obtain finished product.
6. the Chinese medicine composition of severe ox immunity is improved as claimed in claim 1, it is characterised in that the Camellia nitidissima is extracted
Thing, extracting method is as follows：After Camellia nitidissima is crushed through high-speed organization disintegrating machine respectively, pectase is added, be heated to 35~40 DEG C, and
It is stirred continuously, constant temperature keeps 1~2h, and after pectinase treatment terminates, being heated rapidly to 100 DEG C carries out destroy the enzyme treatment, treats temperature
20% alcohol-water mixing leaching liquor is added when being down to 60~70 DEG C, input ultrasonic processor is shaken, residual through filtering
Slag adds the pure water to carry out second ultrasonication, merges filtrate twice, and concentration, constant volume obtain final product extract.
7. as claimed in claim 4 improve severe ox immunity Chinese medicine composition, it is characterised in that the bighead atractylodes rhizome be 20~
40 parts, Sculellaria barbata be 20~40 parts.
8. the Chinese medicine composition of severe ox immunity is improved as claimed in claim 4, it is characterised in that the bighead atractylodes rhizome uses temperature
After for 40~50 DEG C of 2~5min of drying and processing, then insert 10~15min of steaming in vapor, you can.
9. the Chinese medicine composition of severe ox immunity is improved as claimed in claim 4, it is characterised in that the Sculellaria barbata, with phosphorus
Acid dihydride potassium is 1 according to mass ratio:After 0.01-0.07 mixing, fermentation process 5~7 days at being 35~46 DEG C in temperature.
10. the Chinese medicine composition of severe ox immunity is improved as claimed in claim 5, it is characterised in that the spray drying, spray
Mist tower air themperature is 140~160 DEG C, goes out 80~100 DEG C of tower air themperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262522.4A CN106728413A (en) | 2016-12-30 | 2016-12-30 | A kind of Chinese medicine composition and preparation method for improving severe ox immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262522.4A CN106728413A (en) | 2016-12-30 | 2016-12-30 | A kind of Chinese medicine composition and preparation method for improving severe ox immunity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106728413A true CN106728413A (en) | 2017-05-31 |
Family
ID=58953962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611262522.4A Pending CN106728413A (en) | 2016-12-30 | 2016-12-30 | A kind of Chinese medicine composition and preparation method for improving severe ox immunity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106728413A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685990A (en) * | 2018-08-27 | 2018-10-23 | 山东汇融畜牧养殖有限公司 | Enhance the nonreactive Chinese prescription and preparation method thereof of hog cholera vaccine immunization |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565552A (en) * | 2003-06-18 | 2005-01-19 | 薛永新 | Chinese traditional medicine for treating immune hypofunction and disfunction |
-
2016
- 2016-12-30 CN CN201611262522.4A patent/CN106728413A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565552A (en) * | 2003-06-18 | 2005-01-19 | 薛永新 | Chinese traditional medicine for treating immune hypofunction and disfunction |
Non-Patent Citations (1)
| Title |
|---|
| 秦小明等: "金花茶叶药用保健成分提取新工艺研究", 《食品工业科技》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685990A (en) * | 2018-08-27 | 2018-10-23 | 山东汇融畜牧养殖有限公司 | Enhance the nonreactive Chinese prescription and preparation method thereof of hog cholera vaccine immunization |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102258708B (en) | Health-preserving wine and preparation method thereof | |
| CN102204678B (en) | Instant cubilose powder with efficacy of immunity enhancement and preparation method thereof | |
| CN104435775A (en) | Chinese medicinal health-care spirit and preparation method thereof | |
| CN104000127B (en) | Semen phaseoli radiati refrigerant throat-moistening chewable tablet and production method thereof | |
| CN101589801B (en) | Process for manufacturing red ginseng honey slice | |
| CN102846852A (en) | Composite for lowering blood fat and regulating immunity | |
| CN106615431A (en) | Sliced helianthus tuberosus tea and making method thereof | |
| CN101248731B (en) | Cultivation method of acanthopanax root tree plant and acanthopanax root jujube tea with reinforced immunity function | |
| CN110170009A (en) | A kind of Chinese prescription of Antialcoholic liver-protecting, group formula extraction and its preparation method and application | |
| CN1558768A (en) | A pharmaceutical composition made from Chinese traditional medicine and preparation method thereof | |
| CN105028772A (en) | Health care tea used for reducing blood fat and preparation method for health care tea | |
| CN102604750A (en) | Method for preparing forest herbaceous plant biomass detergent | |
| CN108042760A (en) | For nursing one's health the Chinese herbal ointment formula of phlegm-dampness constitution and its processing method | |
| CN107912771A (en) | A kind of stem of noble dendrobium composition with enhancing immune function and preparation method thereof | |
| CN102823700A (en) | Preparation method of compound poria cocos and black garlic filled chocolate | |
| CN106728413A (en) | A kind of Chinese medicine composition and preparation method for improving severe ox immunity | |
| CN108079219A (en) | A kind of topical composition for treating burn and scald and preparation method thereof | |
| CN108813500B (en) | Health-preserving honey paste with effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and regulating human body functions | |
| CN101248877A (en) | Anti-aging functional food and preparation method thereof | |
| CN107812115A (en) | A kind of Chinese medicine composition for treating diabetes | |
| CN108260682A (en) | A kind of hypoglycemic, reducing blood lipid and the health protection tea of blood pressure lowering | |
| CN104189038B (en) | Chinese medicine preparation for nursing one's health female pathology health and immunologic function | |
| CN103181431A (en) | Liver-nourishing health protection tea and preparation method | |
| CN104687051A (en) | Marine organism nutrient solution and preparation method thereof | |
| CN109939188A (en) | Has effects that composition of relieving alcoholism and protecting liver and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171218 Address after: Bai Wei Zhen Nanning Shanglin Zhuang village 530000 the Guangxi Zhuang Autonomous Region towards the Korean Wei No. 25 (the operation of Bai Wei Zhen Chao Zhuang Cun Wei Chao) Applicant after: Guangxi Shanshui cattle husbandry Co., Ltd. Address before: Dong Ge 530022 Nanning Road, the Guangxi Zhuang Autonomous Region No. 118 Nanning Wanda Plaza Green Building No. 3501 West 1 Applicant before: Guangxi Shanshui Agriculture Co., Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |