CN109939188A - Has effects that composition of relieving alcoholism and protecting liver and its preparation method and application - Google Patents
Has effects that composition of relieving alcoholism and protecting liver and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of compositions and its preparation method and application with relieving alcoholism and protecting liver, are made of blueberry, scaly holly root, Chinese knotweed, herba lysimachiae, Oroxylum indicum, strophanthus divaricatus, lophatherum gracile, screwtree root, the five fingers mandarin orange, Jinsha rattan and cherokee rose root.Composition provided by the invention have clearing heat and detoxicating, liver protecting, Dealcoholic sobering-up and it is anti-intoxication the effect of; the discomforts such as headache, dry after alcohol intolerance can effectively being alleviated, be still drank after a night; there is certain protective effect to hepatic injury caused by long-term alcohol, can take for a long time and without side-effects.
Description
Technical field
The invention belongs to the development and application of relieving alcoholism and protecting liver product, and in particular to a kind of combination with sobering up and liver protecting functions
Object, preparation method and application.
Background technique
Long-term alcohol can excessively cause alcoholic fatty liver, cirrhosis, lead to the chronic disease such as " three high ", cardiovascular and cerebrovascular disease
Disease occurs.In order to effectively remove internal excessive alcohol, and alleviate its damage caused by body, currently, dense frequently with drinking
Tea or take certain antialcoholic drugs or drink come alleviate it is drunk after a series of uncomfortable diseases.However, modern pharmacology research table
It is bright, strong tea is drunk after drunk, the theophylline in strong tea can excitor nerve maincenter, have effects that it is certain sober up, still, theophylline tool
There is diuresis, the dehydration of body when acute alcoholism can be aggravated；Meanwhile during alcohol metabolism is acetaldehyde, due to
Its diuresis causes acetaldehyde to have little time to decompose again and be just discharged from kidney, causes to damage to kidney；In addition, theophylline also has
The effect of certain excited heart, cardioacceleration, can aggravate the burden of heart；Theophylline can also cause the contraction of stomach lining, aggravate
Stimulation of the alcohol to stomach lining.Therefore, it is relieved the effect of alcohol using strong tea and improper.The currently used drug much to relieve the effect of alcohol is all west
Medicine may have good effect in a short time, but can not carry out the treatment and maintenance of system to human body, therefore, also uncomfortable
Close long-term take.And Chinese medicinal alcoholism-relieving medicine is mainly made using extracts such as kuh-seng, pueraria lobata, turmeric, ginsengs, not only mouthfeel
Difference, complex process, and dispelling effects of alcohol degree of recognition is poor, causes occupation rate of market low.
It has been reported that blueberry is able to extend alcohol tolerance time, the time of sobering up for shortening rat, slows down alcohol pair
The active influence of ADH, to achieve the effect that relieve the effect of alcohol, but single use blueberry, relieving alcoholism and protecting liver effect is to be improved, and pre- anti-intoxication
Wine it is not sufficiently effective.Therefore, need to propose a kind of relieving alcoholism and protecting liver composition, can either play relieve the effect of alcohol, anti-intoxication effect, simultaneously also
Can liver protecting, conditioning engine body function, alleviate drunk or excessive consumption of alcohol damaged caused by body.
Summary of the invention
The purpose of the present invention is to provide a kind of compositions and its preparation method and application with relieving alcoholism and protecting liver.
In order to achieve the above objectives, the invention adopts the following technical scheme:
A kind of to have effects that the composition of relieving alcoholism and protecting liver, the composition includes blueberry inspissated juice and Chinese medicine extract, institute
Chinese medicine extract is stated to be made of following Chinese medicine material medicine by mass: 2~5 parts of scaly holly root, 2~10 parts of Chinese knotweed, herba lysimachiae 2~
10 parts, 2~15 parts of Oroxylum indicum, 2~10 parts of strophanthus divaricatus, 2~8 parts of lophatherum gracile, 2~10 parts of screwtree root, 2~5 parts of the five fingers mandarin orange, Jinsha
2~5 parts and 2~5 parts of cherokee rose root of rattan；The volume ratio of the Chinese medicine extract and blueberry inspissated juice is 1:4~1:6, blueberry concentration
Total anthocyanidin content is 20%~28% based on mass fraction in juice.
Preferably, the Chinese medicine extract is by 2~3 portions of scaly holly roots, 4~6 parts of Chinese knotweeds, 3~5 portions of herba lysimachiaes, 2~3 parts
Oroxylum indicum, 2~3 parts of strophanthus divaricatus, 3~5 portions of lophatherum graciles, 3~4 portions of screwtree roots, 3~5 parts of the five fingers mandarin oranges, 3~4 parts of Jinsha rattans and 3~4
Part cherokee rose root is made.
Preferably, the Chinese medicine extract is by above-mentioned each ethanol water of the Chinese medicine material medicine through mass fraction 35%~50%
Chinese medical extract aqueous dispersions obtained from ethyl alcohol is evaporated off after solution extraction and decolourizes.
Preferably, the composition further includes corrigent；Corrigent is citric acid and white granulated sugar, wherein citric acid is in group
Closing the mass fraction in object is 0.1%~0.12%, and the mass fraction of white granulated sugar in the composition is 8%~10%.
The above-mentioned preparation method with the composition of relieving alcoholism and protecting liver, comprising the following steps:
1) after blueberry being beaten using enzymatic isolation method extract blueberry juice, by blueberry juice carry out color protection treatment after successively through clear
(specific means is the floccule that can not be digested completely by being centrifuged and removing pericarp etc.), concentration clearly, obtain total anthocyanidin
Content is the blueberry inspissated juice of 20~28% (mass fractions)；
2) by above-mentioned Chinese medicine bulk pharmaceutical chemicals scaly holly root, Chinese knotweed, herba lysimachiae, Oroxylum indicum, strophanthus divaricatus, lophatherum gracile, screwtree root, five
Ethyl alcohol is evaporated off after referring to mandarin orange, Jinsha rattan and cherokee rose root ethanol water refluxing extraction, obtains no alcohol leaching liquor；
3) decolorization will be carried out without alcohol leaching liquor, and will obtain Chinese medicine extract；
4) Chinese medicine extract obtained is uniformly mixed with blueberry inspissated juice according to volume ratio 1:4~1:6.
Preferably, in the step 1), the enzyme that extraction blueberry juice uses is pectase and cellulase, wherein pectin
The dosage of enzyme is 0.25%~0.5% of blueberry volume after being beaten, and the dosage of cellulase is blueberry volume after mashing
0.75%~1%, the temperature of enzymatic hydrolysis is 45~55 DEG C, and the time of enzymatic hydrolysis is 90~120min；The color protection treatment refers in indigo plant
The citric acid (inhibiting blueberry juice that brown stain occurs) of blueberry juice quality 0.6%~0.75% is added in certain kind of berries fruit juice；The concentration
The temperature of processing is 40~50 DEG C.
Preferably, in the step 2), refluxing extraction is specifically includes the following steps: by the drying of each Chinese medicine material medicine, smash
After mix, by the mass fraction of 2~20 times of quality of mixture be 35%~50% ethanol water extract 1~2 time, extraction
Temperature is controlled at 70~80 DEG C, extracts 2~2.5h every time, extracts obtained leaching liquor and merging by filtering separation each time, will
Leaching liquor after merging is concentrated under reduced pressure into no ethanol flavor at 75~80 DEG C, obtains no alcohol leaching liquor.
Preferably, in the step 3), decolorization is specifically includes the following steps: be added active carbon into no alcohol leaching liquor
Decoloration removal of impurities is carried out in 40~75 DEG C afterwards, is filtered after decoloration and (removes active carbon), obtained filtrate i.e. Chinese medicine extract.
Preferably, the preparation method of the composition is further comprising the steps of: the Chinese medicine extract and blueberry is dense
It is seasoned after the mixing of contracting juice with above-mentioned corrigent.
The above-mentioned composition with relieving alcoholism and protecting liver relieves the effect of alcohol in preparation and/or the drug of preventing drunkenness, health care product, function are eaten
Application in product and drink.
Preferably, the composition has the function of preventing and treating alcoholic liver injury.
Evaluation for the above-mentioned composition (abbreviation efficacy) with relieving alcoholism and protecting liver:
1) determine that ethanol-tolerant tests the modeling condition of drunk model
The main influence for investigating the stomach-filling of various dose alcohol to mouse, determines the best white wine stomach-filling amount of drunk mouse.It presses
Stomach-filling, the successful standard of model construction are carried out according to 0.1mL/10g~0.2mL/10g weight are as follows: 80%~90% mouse is drunk,
Quantity of reviving in 8 hours accounts for 80% or more, very low without the dead or death rate.
2) sober-up function
By mouse be divided into model group, tested material group (tested material include various dose efficacy, blueberry inspissated juice, in
Medicament extracting solution) and positive controls, modeling is gavaged by best white wine stomach-filling amount, it is tested after modeling (i.e. after white wine stomach-filling)
Object group gavages matched doses efficacy, blueberry inspissated juice or Chinese medicine extract, record cast group, tested material group (tested material
Including various dose efficacy, blueberry inspissated juice, Chinese medicine extract) and positive controls averagely sober up the time and (refer to drunk
It is drunk i.e. drunk to the time of revival), sleep latency (referring to that stomach-filling terminated to the drunk time), it is existing between comparative group
Difference investigates efficacy to the influence of situation of relieving the effect of alcohol of drinking.
3) anti-intoxication effect
By mouse be divided into model group, tested material group (tested material include various dose efficacy, blueberry inspissated juice, in
Medicament extracting solution) and positive controls, tested material group gavage matched doses efficacy, blueberry inspissated juice or Chinese medicine extract,
After gavaging 30min, each group mouse gavages modeling by best white wine stomach-filling amount, and white wine, which gavages, terminates record cast group, tested material group
It averagely sobers up with positive controls time, sleep latency, existing difference between comparative group investigates efficacy to anti-intoxication
The influence of situation.
4) influence of liver function
Mainly using mice serum ALT, AST as the index of liver protecting effect.
By mouse is divided into normal group, model group, (tested material includes that various dose efficacy, blueberry are dense to tested material group
Contracting juice, Chinese medicine extract) and positive controls, except normal group without white wine stomach-filling, remaining group is filled by best white wine stomach-filling amount
Modeling is taken, after modeling, model group is without any processing, and tested material group gavages matched doses efficacy, blueberry concentration
Juice or Chinese medicine extract take serum to detect mice serum ALT and AST after gavaging administration 1h, investigate efficacy to liver function
The influence of energy.
Under normal circumstances, ALT, AST content are very low in blood, are primarily present in liver cytoplasm.Work as hepatocellular injury
When, intracellular ALT, AST can enter in blood, increase so as to cause ALT, AST in blood, the level of ALT, AST illustrate machine
The quality of body liver function.If composition reduces model mice Serum ALT, AST, illustrate that there is certain liver protecting function
Effect, also illustrates that composition can be absorbed by alimentary canal, plays the role of protecting liver cell, inhibits ALT, AST raising, thus effectively
Prevent and treat alcoholic liver injury.
The beneficial effects of the present invention are embodied in:
The present invention is the primary raw material for preparing relieving alcoholism and protecting liver composition with blueberry and scaly holly root, Chinese knotweed and herba lysimachiae, with
The bulk pharmaceutical chemicals such as Oroxylum indicum, strophanthus divaricatus, lophatherum gracile, screwtree root, the five fingers mandarin orange, Jinsha rattan and cherokee rose root are compatible, relieve the effect of alcohol in promotion
Liver protecting effect is strengthened simultaneously, it is not only rapid-action, but also there is significant preventing drunkenness effect.
Further, the present invention improves blueberry inspissated juice and Chinese medicine extract in compatibility dosage by addition corrigent
Lower existing uncomfortable mouthfeel, improves the oral compliance of composition.
The method that the present invention prepares composition, step is simple, has been sufficiently reserved the effective active composition of raw material, by each component
Mixing can reach significant relieving alcoholism and protecting liver, anti-intoxication and other effects.
Specific embodiment
Invention is further described in detail with reference to embodiments.
(1) efficacy
1. the preparation of blueberry inspissated juice
Pectase and cellulase is added in blueberry after beating, with HCl acid for adjusting pH value to 3.5~3.8, is digested,
Wherein pectase additive amount 0.25% (v/v), cellulase additive amount 0.75% (v/v), enzymolysis time 100min, temperature 50
℃.With this condition, the crushing juice rate of blueberry reaches maximum (up to 90%).The blueberry juice of acquisition is by being added 0.6% (g/g) lemon
Acid carries out at color protection treatment, then clarified (25 DEG C of 4000rpm are centrifuged 20~25min), concentration (45 DEG C, 0.008~0.01MPa)
Blueberry inspissated juice is prepared in reason, and it is 20%~28% (because of blueberry fresh fruit batch that spectrophotometer method, which measures total anthocyanidin content,
It is different and have differences).
2. Chinese herbal medicine pre-processes
Weigh scaly holly root, Chinese knotweed, herba lysimachiae, Oroxylum indicum, strophanthus divaricatus, lophatherum gracile, screwtree root, the five fingers mandarin orange, Jinsha rattan and
Weighed Chinese herbal medicine is dried 2~4h by each 200g of cherokee rose root under the conditions of 80~90 DEG C in an oven respectively, then will be dried respectively
The medicinal pulverizer of dry medium-height grass crushes 30~45s, and herbal powder is obtained after sieving (with reference to the fine powder of States Pharmacopoeia specifications), in which:
Scaly holly root is Aquifoliaceae Holly gradations marked on the beam of steelyard tree (Ilex asprella (Hook.et Arn.) Champ.ex
Benth dry root), bitter, micro-sweet are cool in nature, have effects that it is clearing heat and detoxicating, promote the production of body fluid to quench thirst, reducing pharyngeal swelling, removing blood stasis and acesodyne,
For cold, fever, cough with lung heat, injury thirst, abscess of throat, bruise stasis caused pain etc..
Chinese knotweed is the drying herb of polygonaceae plant Chinese knotweed (Polygonum Chinense Linn), and property is sour, sweet, cool,
There is the effect of clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, can be used for treating the diseases such as diarrhea due to damp-heat, dysentery, jaundice, abscess of throat, damp and hot idoxuridine
Disease.
Herba lysimachiae is the drying herb of Ofthe Primulaceae Lysimachia christinae (Lysimachia christinae Hance), summer
The harvesting of two season of autumn, removes impurity, dries.
Oroxylum indicum is the dry mature seed of Bignoniaceae plant oroxylum indicum (Oroxylumindicum (L.) Vent.).Autumn,
Two season of winter harvests ripening fruits, is exposed to the sun to cracking of fruit, takes out seed, dry.
Strophanthus divaricatus is the dried leaf of Tiliaceae plant Fallopia nervosa (Microcos paniculata L.).Summer, Qiu Erji are adopted
It receives, removes discarding stalk and impurity, dry in the shade or dry.
Lophatherum gracile is the drying cauline leaf of grass henon bamboo leaf (Lophatherum gracile Brongn.).Summer
It taps, dries before not taking out flower spike.
Screwtree root is the dry root of Sterculiaceae plant screwtree root (Helicteresangusti-folia L.).There is nourishing to support
Blood, menstruation regulating kidney tonifying, protect liver, ease constipation, softening skin, the functions such as diuresis, laxative, for assisting in the treatment of chronic constipation, tinnitus, gums
Scorching, anaemia, alopecia, bicker ulcer and migraine, hypopsia, the diseases such as feel dizzy.
The five fingers mandarin orange is the herb of Verbenaceae five-leaved chaste tree (Vitex negundo L.), with anti-inflammatory, analgesia, antidiarrheal
Effect.
Jinsha rattan is perennial pteridophyte Lygodium japonicum (the Lygodium japonicum of Lygodiaceae Lygodium
(Thunb.) Sw.), Lygodium scandens (L.microphyllum (Cav.) R.Br.) or crankshaft Lygodium japonicum (L.flexuo-sum
(L.) Sw.) dry aerial parts.Has effects that clearing heat and detoxicating, promoting diuresis for stranguria.
Cherokee rose root is dry root, the root skin of the rosaceous plant fruit of Cherokee rose (Rosa laevigata Michx), and nature and flavor are sour and astringent
It is flat.
3. the leaching liquor of Chinese herbal medicine active constituent
Take scaly holly root 15g, Chinese knotweed 20g, herba lysimachiae 15g, Oroxylum indicum 15g, strophanthus divaricatus 15g, lophatherum gracile 15g, screwtree root
15g, the five fingers mandarin orange 20g, Jinsha rattan 15g and cherokee rose root 20g are added in the ethanol solution that 500mL concentration is 40% 2h that flows back, control
Temperature processed is 75 DEG C, and filters and obtain filtrate A, and gained filter residue repeats reflux 2h and filters to obtain liquor B, and filtrate A, B are merged,
It is concentrated under reduced pressure into no ethanol flavor at 75 DEG C, obtains no alcohol leaching liquor.
4. the purification of Chinese herbal medicine active constituent
To gained without being added in alcohol leaching liquor medical decoloration active carbon (every 10L adds 10g active carbon), decoloration (75 DEG C) 10~
20min removes peculiar smell and part resin, colloid substance, then filter repeatedly to filtrate it is limpid, it is transparent until, obtain Chinese medicine and mention
Take liquid.
5. the preparation of efficacy
The blueberry inspissated juice of 5 times of volumes is added into Chinese medicine extract, and citric acid is added and white granulated sugar is seasoned, group
The additive amount for closing citric acid in object is 0.1~0.12%, and the additive amount of white granulated sugar is 8~10%, after adjusting mouthfeel, obtains effect
Composition.
(2) it is evaluated the effect of composition
1. influence of the various dose alcohol stomach-filling to mouse
Healthy mice 110 are taken, half male and half female is adaptive feeding one week, random to be grouped, and every group 10, fasting before testing
12h, 52 degree or so of white wine carry out ethanol-tolerant test, and the results are shown in Table 1: when with 0.2mL/10g weight stomach-filling, mouse has
60% is dead, and mortality is excessive；When with 0.1mL/10g weight stomach-filling, mouse has 70% not drunk；With the filling of 0.16mL/10g weight
When stomach, mouse is most of drunk, and revival quantity is relatively more, and death is relatively fewer, therefore dead mouse when both having avoided test
Excessively test data is caused to lack, lack data because mouse is not drunk when in turn avoiding test, therefore uses 0.16mL/10g body
Weight is best white wine stomach-filling amount.
1. mouse ethanol-tolerant amount test result of table
2. composition sober-up function
Healthy mice 70, weight 20g or so are taken, half male and half female, adaptive feeding one week, stochastic averagina was divided into 7 groups, packet
Include model group, tested material low dose group, tested material middle dose group, tested material high dose group, blueberry inspissated juice group, Chinese medicine extract
Each group mouse after fasting 12h, is gavaged modeling by best white wine stomach-filling amount by group and positive controls, after modeling, tested material
Group composition the effect of various dose (0.2mL/10g, 0.4mL/10g, 0.8mL/10g) and blueberry inspissated juice, traditional Chinese medicine extraction
Liquid gavages, and positive controls are gavaged with Hai Wangjin cup (0.5mL/10g), and model group is without any processing.After drug gavages
Record.
2. tested material sober-up function result of table
Note: n=10, compared with model group:*P < 0.05,**p<0.01
As can be seen from Table 2, under equivalent assay conditions, tested material low dose group averagely sober up the time be 105min, by
Examination object middle dose group averagely sober up the time be 76min, tested material high dose group averagely sober up the time be 52min, positive controls
The time sober up averagely for 54min, intuitively finds out that tested material high dose group is similar with positive controls dispelling effects of alcohol.It is examined by t
Test it can be seen that, tested material group is low, there are significant difference (P < 0.05), tested material high dose group and moulds for middle dosage and model group
There are extremely significant sex differernce (P < 0.01) for type group.Sleep latency result is similar.In addition, blueberry inspissated juice, Chinese medicine extract
Group can effectively relieve the effect of alcohol, but sleep latency and time of sobering up are suitable with tested material middle dose group effect, thus may be used
To obtain, efficacy has apparent antialcoholism action to drunk, and is significantly better than and is mentioned using blueberry extract or Chinese medicine merely
Take object.
3. composition preventing drunkenness effect
Healthy mice 70, weight 20g or so, half male and half female, adaptive feeding one week, stochastic averagina was divided into 7 groups；If mould
Type group, tested material low dose group, tested material middle dose group, tested material high dose group, blueberry inspissated juice group, Chinese medicine extract group and
Positive controls, fasting 12h before groups of animals is tested, tested material group with various dose (0.2mL/10g, 0.4mL/10g,
0.8mL/10g) the effect of composition, blueberry inspissated juice, Chinese medicine extract gavage, positive controls Hai Wangjin cup (0.5mL/
It 10g) gavages, model group is without any processing, and after gavaging 30min, each group mouse is gavaged by best white wine stomach-filling amount, and white wine fills
It is recorded after clothes.
3. tested material preventing drunkenness efficacy outcomes of table
Note: n=10, compared with model group:*P < 0.05,**p<0.01
As can be seen from Table 3, under equivalent assay conditions, tested low object dosage group averagely sober up the time be 135min, by
Examination object middle dose group averagely sober up the time be 85min, tested material high dose group averagely sober up the time be 60min, positive controls
The time sober up averagely for 56min, intuitively finds out that positive controls are not bright in terms of pre- preventing drunkenness with tested material high dose group
Significant difference is different.By t examine it can be seen that, tested material low dose group, middle dose group and model group there are significant difference (P <
0.05), there are extremely significant sex differernce (P < 0.01), sleep latency result is similar for tested material high dose group and model group.Separately
Outside, blueberry inspissated juice, Chinese medicine extract group can effective preventing drunkenness, but commented according to sleep latency and time of sobering up
Valence, preventing drunkenness effect are generally between tested material low dose group and middle dose group, therefore deduce that, efficacy has
More obvious anti-drunk function is better than blueberry extract or Chinese medical extract.
4. composition liver protection function
Healthy mice 80, weight 20g or so, half male and half female adaptive feeding one week, is randomly divided into 8 groups；If normal
Group, model group, tested material low dose group, tested material middle dose group, tested material high dose group, blueberry inspissated juice group, traditional Chinese medicine extraction
Liquid group and positive controls.Fasting 12h before groups of animals is tested, normal group is pressed most preferably white without white wine stomach-filling, remaining each group
Wine stomach-filling amount gavages modeling, after modeling, normal group, model group it is without any processing, positive controls with sea Wang Jin crouching
(0.5mL/10g) is gavaged, and tested material group is combined with the effect of various dose (0.2mL/10g, 0.4mL/10g, 0.8mL/10g)
Object, blueberry inspissated juice, Chinese medicine extract gavage；After gavaging administration 1 hour, in all groups of mouse socket of the eye arteries and socket of the eye venous blood collection,
Serum is taken to detect mice serum ALT, AST.
4. composition liver protecting efficacy outcomes of table
Note: n=10, compared with normal group:##p<0.01；Compared with model group:*P < 0.05,**p<0.01
As seen from Table 4, model group Serum ALT, AST more normally organize significantly raised (P < 0.01)；It is handled through efficacy,
Tested material height, middle dose group Serum ALT, AST are significantly lower than model group.Blueberry inspissated juice group and Chinese medicine extract group equally have
Certain liver protecting effect, effect are suitable with tested material low dose group.It therefore deduces that, efficacy, which has, to be become apparent from
Liver protection function, be better than blueberry extract or Chinese medical extract.
(3) usage and dosage of composition
25~20 minutes before drinking, 250mL is disposably taken, is taken 1 time.
It 4 after drinking, respectively takes within 8,12 hours once, each taking 250mL, takes altogether 3 times.
It can be concluded that, composition has heat-clearing solution the effect of relieving alcoholism and protecting liver provided by the invention in conjunction with actually taking effect
Poison, liver protecting, Dealcoholic sobering-up and it is anti-intoxication the effect of, headache, dry etc. be not no after can effectively alleviating alcohol intolerance, be still drank after a night
It is suitable, there is certain protective effect to hepatic injury caused by long-term alcohol, can take for a long time and without side-effects.
Claims (10)
1. a kind of have effects that the composition of relieving alcoholism and protecting liver, it is characterised in that: the composition includes blueberry inspissated juice and Chinese medicine
Extracting solution, the Chinese medicine extract are made of following Chinese medicine material medicine by mass: 2~5 parts of scaly holly root, 2~10 parts of Chinese knotweed,
2~10 parts of herba lysimachiae, 2~15 parts of Oroxylum indicum, 2~10 parts of strophanthus divaricatus, 2~8 parts of lophatherum gracile, 2~10 parts of screwtree root, the five fingers mandarin orange 2
~5 parts, 2~5 parts of Jinsha rattan and 2~5 parts of cherokee rose root；The volume ratio of the Chinese medicine extract and blueberry inspissated juice is 1:4~1:
6, total anthocyanidin content is 20%~28% based on mass fraction in blueberry inspissated juice.
2. a kind of according to claim 1 have effects that the composition of relieving alcoholism and protecting liver, it is characterised in that: the Chinese medicine extract
By 2~3 portions of scaly holly roots, 4~6 parts of Chinese knotweeds, 3~5 portions of herba lysimachiaes, 2~3 portions of Oroxylum indicums, 2~3 parts of strophanthus divaricatus, 3~5 portions of henon bamboos
Leaf, 3~4 portions of screwtree roots, 3~5 parts of the five fingers mandarin oranges, 3~4 parts of Jinsha rattans and 3~4 parts of cherokee rose roots are made.
3. a kind of according to claim 1 have effects that the composition of relieving alcoholism and protecting liver, it is characterised in that: the Chinese medicine extract
It is obtained from each Chinese medicine material medicine is evaporated off ethyl alcohol after the extraction of the ethanol water of mass fraction 35%~50% and is decolourized
Chinese medical extract aqueous dispersions.
4. a kind of according to claim 1 have effects that the composition of relieving alcoholism and protecting liver, it is characterised in that: the composition also wraps
Including corrigent, corrigent is citric acid and white granulated sugar, wherein the mass fraction of citric acid in the composition is 0.1%~
0.12%, the mass fraction of white granulated sugar in the composition is 8%~10%.
5. a kind of preparation method with the composition of relieving alcoholism and protecting liver, it is characterised in that: the following steps are included:
1) after blueberry being beaten using enzymatic isolation method extract blueberry juice, by blueberry juice carry out color protection treatment after successively it is clarified,
Concentration obtains blueberry inspissated juice, and total anthocyanidin content is 20%~28% based on mass fraction in blueberry inspissated juice；
2) by 2~5 parts of Chinese medicine material medicine scaly holly root, 2~10 parts of Chinese knotweed, 2~10 parts of herba lysimachiae, 2~15 parts of Oroxylum indicum, paniculata
2~10 parts of leaf, 2~8 parts of lophatherum gracile, 2~10 parts of screwtree root, 2~5 parts of the five fingers mandarin orange, 2~5 parts of Jinsha rattan and 2~5 parts of cherokee rose root,
With ethyl alcohol is evaporated off after ethanol water refluxing extraction, no alcohol leaching liquor is obtained；
3) decolorization will be carried out without alcohol leaching liquor, and will obtain Chinese medicine extract；
4) Chinese medicine extract is uniformly mixed with blueberry inspissated juice according to volume ratio 1:4~1:6.
6. a kind of preparation method with the composition of relieving alcoholism and protecting liver according to claim 5, it is characterised in that: described
In step 1), the enzyme that extraction blueberry juice uses is pectase and cellulase, wherein the dosage of pectase is blueberry after mashing
The 0.25%~0.5% of volume, the dosage of cellulase are 0.75%~1% of blueberry volume after being beaten, and the temperature of enzymatic hydrolysis is
45~55 DEG C, the time of enzymatic hydrolysis is 90~120min；The color protection treatment refers to the addition blueberry juice quality in blueberry juice
0.6%~0.75% citric acid；The temperature of the concentration is 40~50 DEG C.
7. a kind of preparation method with the composition of relieving alcoholism and protecting liver according to claim 5, it is characterised in that: described
In step 2), refluxing extraction is specifically includes the following steps: in the matter of 2~20 times of quality after each Chinese medicine material medicine is dried, is smashed
It mixes and extracts 1~2 time in the ethanol water that amount score is 35%~50%, extraction temperature is controlled at 70~80 DEG C, every time
2~2.5h is extracted, each time is separated and extracts obtained leaching liquor and merging, the leaching liquor after merging is depressurized at 75~80 DEG C dense
It is reduced to no ethanol flavor.
8. a kind of preparation method with the composition of relieving alcoholism and protecting liver according to claim 5, it is characterised in that: described
In step 3), decolorization after addition active carbon into no alcohol leaching liquor in 40~75 DEG C specifically includes the following steps: taken off
Color removal of impurities, removes active carbon after decoloration, obtains Chinese medicine extract.
9. a kind of preparation method with the composition of relieving alcoholism and protecting liver according to claim 5, it is characterised in that: described
The preparation method of composition is further comprising the steps of: after the Chinese medicine extract is mixed with blueberry inspissated juice with corrigent into
Row seasoning.
10. a kind of composition as described in claim 1 with relieving alcoholism and protecting liver relieves the effect of alcohol and/or the medicine of preventing drunkenness preparing
Application in object, health care product, functional food and drink.
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| CN115336690A (en) * | 2022-08-22 | 2022-11-15 | 北京光信商贸有限公司 | Herbaceous plant concentrated solution, preparation method and application thereof, herbaceous plant beverage and preparation method thereof |
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| CN102894136A (en) * | 2011-07-26 | 2013-01-30 | 南通金土地绿色食品有限公司 | Herbal tea composition |
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| CN115336690A (en) * | 2022-08-22 | 2022-11-15 | 北京光信商贸有限公司 | Herbaceous plant concentrated solution, preparation method and application thereof, herbaceous plant beverage and preparation method thereof |
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