CN106728368A - A kind of anti-Fatigue Composition and preparation method thereof - Google Patents

A kind of anti-Fatigue Composition and preparation method thereof Download PDF

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Publication number
CN106728368A
CN106728368A CN201611149628.3A CN201611149628A CN106728368A CN 106728368 A CN106728368 A CN 106728368A CN 201611149628 A CN201611149628 A CN 201611149628A CN 106728368 A CN106728368 A CN 106728368A
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preparation
fatigue composition
capsule
fatigue
wilsonii
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王松平
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Shenzhen Yun Yun Industrial Co Ltd
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Shenzhen Yun Yun Industrial Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of anti-Fatigue Composition, it contains following component by weight percentage：Rhodiola root 15 45%, wilsonii 5 25%, barrenwort 10 30%, Psoralea corylifolia 8 20%, the fruit of Chinese wolfberry 3 18%, mulberries 5 20%, date 2 8%, starch 0.3 1.2%.Invention additionally discloses the preparation method of the anti-Fatigue Composition.Anti-Fatigue Composition provided by the present invention, organically it is combined together by by various raw materials, and each component effect collaboration, mechanism is complementary, can effectively supplement the natural nutrient component and physiological activator of needed by human body, effectively improves brain tissue pathological changes and finger tip detecting sphygmus and blood oxygen saturation, improve microcirculation, the function of human body anoxia endurance is improved, long-term taking has no toxic side effect, can comprehensively and systematically fatigue-relieving and strengthen immunity.

Description

A kind of anti-Fatigue Composition and preparation method thereof
Technical field
The invention belongs to health product technology field, and in particular to a kind of anti-Fatigue Composition and preparation method thereof.
Background technology
Into 21 century, China's economic fast development, material extreme enrichment, internet is advanced by leaps and bounds, various investments, wealth Effect, chases money, fame and gain, and people's spirit level there occurs basic transformation, operating pressure, life stress, social contradications, family Front yard entanglement, ideological change, all as unhealthful great inducement.Various diseases are hard to guard against, and inferior health turns into people First killer of class health.
All over the body under powerless lassitude, dizziness, nervous, pressure, gloomy, palpitaition, shortness of breath, eye-blurred, memory Drop, insomnia, are the presentations of inferior health with three omens high, and any risk factor of these recessive disorders all may directly be led Cause disease to deteriorate rapidly, or even extreme situation generation occur, preventing and treating is a great and urgent problem early.
The theoretical explanation of inferior health：Doctor trained in Western medicine thinks that above-mentioned symptom is the combined reaction of the complicated physiological acoustic signals of body, Body nerve, endocrine, immune all system fading margins can be caused not normal.The traditional Chinese medical science thinks, spleen governing muscles four limbs, deficiency-weakness of spleen-QI, spleen sun Not up to four ends, then limb muscle fatigue and weak；Liver blood cage bar arteries and veins, Shu Guanjie is brown bear pole sheet；Kidney essence and main bone life marrow, Kidney deficiency and liver, blood and essence asthenia then tendon and vessel lose in moisten support then see muscles and bones impotence；Done in kidney essense in brain, brain is hollow, then have a headache, remember Power goes down；Speen-kidney dificiency, deficiency of both vital energy and Yin are this pathogenetic Fundamentals as can be seen here.Inferior health is belonged into gas in motherland's medical science Empty, deficient, overstrain category, it is believed that this sick cause of disease is multi-source, has with exopathogen, feelings will, diet, overstrain and constitution factors Close, and be related to how dirty the heart, liver, spleen, lung, kidney etc. be is lacked of proper care by gas, blood, yin, yang function is undermined in various degree, the five internal organs are human bodies Most important internal organs, directly affect the various functions of human body.
China possesses extremely abundant natural Chinese medicinal herb resource, such as the sachalin rhodiola rhizome in Crassulaceae, in Araliaceae Wilsonii, the barrenwort in Berberidaceae plant, the fruit of Chinese wolfberry in plant of Solanaceae, the Psoralea corylifolia in legume etc. is all research and development The important source material of anti-fatigue effect food.Theoretical according to China's traditional " integration of drinking and medicinal herbs ", exploitation is anti-tired with national characters Labor food, " integration of drinking and medicinal herbs " theory is the unique advantage that China develops functional food.
Sachalin rhodiola rhizome belongs to Crassulaceae, and it can mitigate the Pituitary Adrenalcortical system that stress cause in form and work( Changing and the adrenal cortex function for having occurred and that failure function can also be made to recover normal quickly on energy.Meanwhile, largely Experimental study document also reports sachalin rhodiola rhizome and can improve the binding ability of hemoglobin and oxygen, supplements human body oxygen content, It is space flight in antifatigue, cardiac stimulant, radiation, the pharmacological action removed anerobic glycolysis product (lactic acid), remove the aspects such as free radical The indispensable equipment such as member, mountaineer.It is also widely used in improve microcirculation, improve body immunity, failure of memory, in The prescription that wind patient recovers, not any side effect report.
Wilsonii is Araliaceae wilsonii Acanthopanax senticosus (Rupr.et Maxim) Harms's Dry root and rhizome or stem.Wilsonii can significantly improve the lactic acid dehydrogenase activity after activity, reduce blood lactase acid and blood urea nitrogen Content, improve Mice Body in muscle glycogen and hepatic glycogen storage level, improve mouse movement endurance, with good antifatigue work With.Therefore the blood lactase acid for being caused to body anaerobic metabolism after motion is raised, and muscle glycogen, hepatic glycogen decline has good suppression to make With being widely used in the prescription component of the three high patients.
Barrenwort is the excessive sheep Epimedium breviornum Maxim of Berberidaceae plant, Epimedium sagittatum Epimedium Sagittatum (Sieb.et Zucc.) Maxim, E. Pubescens Epimedium pubescensMaxim, E. wushanense T. S. Ying Epimedium wushanense T.S.Ying's or korean epimedium herb Epimediunkoreanum Nakai dries overground part Point, effective kidney tonifying, lot of documents shows, barrenwort can in various degree improve sportsman's hemoglobin, blood sugar, blood lactase acid level, Improve metabolism, be conducive to maintaining high-intensity exercise ability, its equal Wheat Protein can make the MDA in blood plasma and tissue Reduce, the SOD activity of red blood cell increases.
The fruit of Chinese wolfberry is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L., is conventional nourishing class Chinese medicine.Its is sweet, mild-natured, returns liver and kidney channel, the function of having tonifying liver, kidney-nourishing, improving eyesight, for consumption consumptive loss, soreness of waist and knee joint, dizzy Dizzy tinnitus, Heat Diabetes, blood deficiency chlorosis, the dizzy illness such as not clear.
Psoralea corylifolia is the dry mature fruit of legumes psoraleae Psoralea corylifolia L., with expansion Blood vessel, increases the effect of myocardial contractive power, is conducive to improving some symptoms of anoxic and fatigue.
Mulberries, date are integration of drinking and medicinal herbs article, it is experimentally confirmed that mulberries, date have promotion hematopoietic growth, promote hematopoiesis The effect of functional rehabilitation, the body blood supply insufficiency for indirectly being caused to anoxic has improvement result.
The content of the invention
For the defect that prior art is present, the invention provides a kind of anti-Fatigue Composition, said composition is directed to five The loss of dirty function is not enough, improves function of five internal organs with help and starts with, and strengthens cardio-pulmonary function, improves body oxygen carrying and fortune oxygen energy Power, alleviating significantly includes the anoxic of the heart, brain tissue and other body tissues, removes free radical and fundamentally solves inferior health product Raw root, recovers physical vigor.The invention also discloses the preparation method of the anti-Fatigue Composition.
The purpose of the present invention is achieved through the following technical solutions：
A kind of anti-Fatigue Composition, it contains following component by weight percentage：Rhodiola root 15-45%, wilsonii 5- 25%, barrenwort 10-30%, Psoralea corylifolia 8-20%, fruit of Chinese wolfberry 3-18%, mulberries 5-20%, date 2-8%, starch 0.3- 1.2%.
Preferably, it contains following component by weight percentage：Rhodiola root 20-40%, wilsonii 10-20%, excessive sheep Leaves of pulse plants 10-25%, Psoralea corylifolia 8-18%, fruit of Chinese wolfberry 5-15%, mulberries 6-18%, date 3-7%, starch 0.5-1.0%.
Preferably, wherein per in antifatigue combination described in 100g, the content of rhodioloside is not less than 72mg, and Thick many candies contain Amount is not less than 200mg；And water content≤the 9.0wt% of the anti-Fatigue Composition.
A kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 40- 80 mesh sieves, take sieving standby；
2) the step of weighing formula ratio 1) in rhodiola root, wilsonii and barrenwort, add 5-15 times to measure volumetric concentration to be The alcohol reflux of 50-80% is extracted more than twice, each refluxing extraction 1-3 hours, and filtration, merging filtrate, filtrate is concentrated into leaching Cream；
3) the step of weighing formula ratio 1) in Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, date, add 6-15 times of decocting boil to Less twice, each 1-3 hours, filtration, merging filtrate, filtrate is concentrated into medicinal extract；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, be 60-80 DEG C in temperature, vacuum is Dry extract is vacuum dried to obtain under conditions of 0.04-0.1MPa, the dry extract is crushed, sieving takes sieving standby；
5) by step 4) obtained by dry extract add the starch of formula ratio, be well mixed, fill capsule, obtain final product described anti-tired Labor composition；
Preferably, wherein step 2) described in the condition that concentrates for vacuum is 0.07-0.08MPa, 60-65 DEG C of temperature.
Preferably, wherein step 3) described in the condition that concentrates be vacuum 0.07-0.08MPa, 60-65 DEG C of temperature.
Preferably, wherein step 2) described in relative density of the medicinal extract at 55-60 DEG C be 1.1-1.3.
Preferably, wherein step 3) described in relative density of the medicinal extract at 55-60 DEG C be 1.1-1.3.
Preferably, wherein step 4) mesh number of gained dry extract is 60-80 mesh.
Preferably, wherein also including step 5) capsule that obtains is placed in capsule polisher and polishes, until capsule surface It is bright and clean, do not glue powder.
Compared with prior art, the present invention at least has advantages below：
Anti-Fatigue Composition provided by the present invention, it uses pure natural raw material, sachalin rhodiola rhizome supplement heart and brain blood in side Oxygen content, strengthening the spleen and replenishing qi is promoting blood circulation and removing blood stasis, radioresistance, removes free radical；Wilsonii warmly invigorating spleen and stomach improves cardiopulmonary vigor, blood-nourishing peace God；Barrenwort kidney-replenishing, benefiting essence-blood；Psoralea corylifolia Psoralen establishing-Yang, strengthening the spleen and replenishing qi；The fruit of Chinese wolfberry is nourishing liver and kidney, strengthening the essence green blood；Mulberries, Nourishing kidney yin, promotes the production of body fluid to quench thirst；Organically be combined together these raw materials by date tonifying spleen calming heart, nourishing qi and blood, and each group is allocated as With collaboration, mechanism is complementary, can effectively supplement the natural nutrient component and physiological activator of needed by human body, effectively improves brain group Knit oxygen saturation and finger tip detecting sphygmus and blood oxygen saturation, improve microcirculation, improve the function of human body anoxia endurance, long-term taking without Toxic and side effect, can comprehensively and systematically fatigue-relieving and strengthen immunity.
(2) preparation method of anti-Fatigue Composition provided by the present invention, it is rationally molten according to the water-soluble of composition, alcohol Property, it is combined using water extraction and alcohol extraction process, be conducive to fully extracting the active ingredient in raw material, and use low-temperature vacuum drying Technology, keeps important activity composition, allows stable and controllable for quality, it can be ensured that curative effect；And capsule is easy to take, carry and transport, And small volume, with the wider feature of applicable crowd.
Brief description of the drawings
Fig. 1 is the process chart of the preparation method of anti-Fatigue Composition provided by the present invention；
Fig. 2 is that after anti-Fatigue Composition provided by the present invention is taken, subject closes dense in 6d test mesencephalic tissue oxygen The numerical value of degree；
Fig. 3 is that after anti-Fatigue Composition provided by the present invention is taken, finger tip blood oxygen of the subject in 6d tests is dense Degree (SpO2The numerical value of concentration average (including the measured value at upper and lower noon)
Fig. 4 is that after anti-Fatigue Composition provided by the present invention and instant coffee is taken, the brain tissue oxygen of subject is satisfied With the numerical value of degree.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples, and following examples are descriptive, are not Limited, it is impossible to protection scope of the present invention is limited with this.
When stated in the form of scope, preferred scope or preferred numerical upper limits and lower limit certain amount, concentration or its It is worth or when parameter, it should be understood that equivalent to specifically disclose by by any pair range limit or preferred value with appoint Any scope that meaning range lower limit or preferred value combine, without considering whether the scope specifically discloses.Unless referred in addition Go out, number range value listed herein is in the end points including scope, and all integers and fraction within the scope of this.
Unless otherwise indicated, all of percentage, number, ratio etc. are by weight herein.
The material of this paper, method and embodiment are exemplary, and unless stated otherwise, be should not be construed as restricted 's.
Details are as follows for the present invention：A kind of anti-Fatigue Composition, it contains following component by weight percentage：Rhodiola root 15-45%, wilsonii 5-25%, barrenwort 10-30%, Psoralea corylifolia 8-20%, fruit of Chinese wolfberry 3-18%, mulberries 5-20%, date 2-8%, starch 0.3-1.2%, the percentage by weight sum of above component is 100%.
Wherein, anti-Fatigue Composition provided by the present invention, by weight percentage, including 15-45% rhodiola root, more Preferably 20-40%, in anti-Fatigue Composition provided by the present invention in the antifatigue combinations of every 100g, the content of rhodioloside is not Less than 72mg, the content of Thick many candies is not less than 200mg, and the anti-Fatigue Composition water content≤9.0wt%.To rhodiola root Source is not particularly limited, using the rhodiola root for meeting the technical requirements familiar to the person skilled in the art.
Anti-Fatigue Composition provided by the present invention, the wilsonii of use, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry, mulberries and shallow lake Powder is purchased in market, or is prepared by method well known in the prior art.
As shown in figure 1, a kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 40- 80 mesh sieves, take sieving standby；
2) the step of weighing formula ratio 1) in rhodiola root, wilsonii and barrenwort, add 5-15 times to measure volumetric concentration to be The alcohol reflux of 50-80% is extracted more than twice, each refluxing extraction 1-3 hours, and filtration, merging filtrate, filtrate is concentrated into leaching Cream；
3) the step of weighing formula ratio 1) in Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, date, add 6-15 times of decocting boil to Less twice, each 1-3 hours, filtration, merging filtrate, filtrate is concentrated into medicinal extract；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, be 60-80 DEG C in temperature, vacuum is Dry extract is vacuum dried to obtain under conditions of 0.04-0.1MPa, the dry extract is crushed, sieving takes sieving standby；
5) by step 4) obtained by dry extract add formula ratio starch, be well mixed, fill capsule, obtain final product.
Anti-Fatigue Composition capsule provided by the present invention is 0.3g/, and eating method is daily one sooner or later.
Embodiment 1：
A kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 40 Mesh sieve, it is standby；
2) weigh by step 1) pulverize and sieve after rhodiola root 15kg, wilsonii 23kg and barrenwort 25kg, add 5 times Measure the alcohol reflux that volumetric concentration is 50% to extract twice, each refluxing extraction 1.5 hours, filtration, merging filtrate, filtrate is in pressure It is by force -0.07MPa, temperature is to be concentrated into medicinal extract at 60 DEG C, relative density of the gained medicinal extract in 55 DEG C of temperature is 1.12；
3) weigh by step 1) pulverize and sieve after Psoralea corylifolia 18kg, fruit of Chinese wolfberry 11kg and mulberries 5kg, and date 2kg, adds 6 times of decocting to boil three times, 1 hour every time, filters, merging filtrate, and filtrate is 0.08MPa in vacuum, and temperature is It is concentrated into medicinal extract at 60 DEG C, relative density of the gained medicinal extract in 55 DEG C of temperature is 1.1；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, be 60 DEG C in temperature, vacuum is Dry extract is vacuum dried to obtain under conditions of 0.04MPa, the dry extract is crushed, cross 60 mesh sieves, it is standby；
5) by step 4) obtained by dry extract add starch 1kg, be well mixed, fill capsule, obtain final product；
6) by step 5) capsule that obtains is placed in capsule polisher and polishes, until capsule surface is bright and clean, does not glue powder.
Embodiment 2：
A kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 50 Mesh sieve, it is standby；
2) weigh by step 1) pulverize and sieve after rhodiola root 25kg, wilsonii 15kg and barrenwort 30kg, add 6.5 Measure the alcohol reflux that volumetric concentration is 55% again to extract three times, each refluxing extraction 1 hour, filtration, merging filtrate, filtrate is in pressure It is by force -0.07MPa, temperature is to be concentrated into medicinal extract at 62 DEG C, relative density of the gained medicinal extract in 56 DEG C of temperature is 1.15；
3) weigh by step 1) pulverize and sieve after Psoralea corylifolia 8kg, fruit of Chinese wolfberry 5.7kg and mulberries 11kg, and date 5kg, adds 7 times of decocting to boil twice, 1.3 hours every time, filtration, and merging filtrate, filtrate is 0.07MPa, temperature in vacuum To be concentrated into medicinal extract at 62 DEG C, relative density of the gained medicinal extract in 55 DEG C of temperature is 1.13；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, be 60 DEG C in temperature, vacuum is Dry extract is vacuum dried to obtain under conditions of 0.05MPa, dry extract is crushed, cross 60 mesh sieves, it is standby；
5) by step 4) obtained by dry extract add starch 0.3kg, be well mixed, fill capsule, obtain final product；
6) by step 5) capsule that obtains is placed in capsule polisher and polishes, until capsule surface is bright and clean, does not glue powder.
Embodiment 3：
A kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 60 Mesh sieve, it is standby；
2) weigh by step 1) pulverize and sieve after rhodiola root 30kg, wilsonii 10kg and barrenwort 17kg, add 7.5 Measure the alcohol reflux that volumetric concentration is 60% again to extract three times, each refluxing extraction 1.8 hours, filtration, merging filtrate, filtrate exists Pressure is -0.075MPa, and temperature is to be concentrated into medicinal extract at 65 DEG C, and relative density of the gained medicinal extract in 57 DEG C of temperature is 1.18；
3) weigh by step 1) pulverize and sieve after Psoralea corylifolia 14kg, fruit of Chinese wolfberry 12kg and mulberries 11.8kg, Yi Ji great Jujube 4kg, adds 8 times of decocting to boil four times, 1.5 hours every time, filters, merging filtrate, and filtrate is 0.08MPa, temperature in vacuum Spend to be concentrated into medicinal extract at 65 DEG C, relative density of the gained medicinal extract in 58 DEG C of temperature is 1.2；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, be 69 DEG C in temperature, vacuum is Dry extract is vacuum dried to obtain under conditions of 0.065MPa, the dry extract is crushed, cross 70 mesh sieves, it is standby；
5) by step 4) obtained by dry extract add starch 1.2kg, be well mixed, fill capsule, obtain final product；
6) by step 5) capsule that obtains is placed in capsule polisher and polishes, until capsule surface is bright and clean, does not glue powder.
Embodiment 4：
A kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 75 Mesh sieve, it is standby；
2) weigh by step 1) pulverize and sieve after rhodiola root 38kg, wilsonii 5kg and barrenwort 10kg, add 11 times Measure the alcohol reflux that volumetric concentration is 70% to extract four times, each refluxing extraction 2 hours, filtration, merging filtrate, filtrate is in pressure It is -0.08MPa, to be concentrated into medicinal extract at 65 DEG C, relative density of the gained medicinal extract in temperature 60 C is 1.2 to temperature；
3) weigh by step 1) pulverize and sieve after Psoralea corylifolia 14kg, fruit of Chinese wolfberry 15kg and mulberries 11kg, and date 6.4kg, adds 13.5 times of decocting to boil four times, 2.1 hours every time, filters, merging filtrate, and filtrate is in vacuum 0.075MPa, temperature is to be concentrated into medicinal extract at 65 DEG C, and relative density of the gained medicinal extract in 58 DEG C of temperature is 1.23；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, be 70 DEG C in temperature, vacuum is Dry extract is vacuum dried to obtain under conditions of 0.08MPa, the dry extract is crushed, cross 75 mesh sieves, it is standby；
5) by step 4) obtained by dry extract add starch 0.6kg, be well mixed, fill capsule, obtain final product；
6) by step 5) capsule that obtains is placed in capsule polisher and polishes, until capsule surface is bright and clean, does not glue powder.
Embodiment 5：
A kind of preparation method of anti-Fatigue Composition, comprises the following steps：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 40- 80 mesh sieves, it is standby；
2) weigh by step 1) pulverize and sieve after rhodiola root 45kg, wilsonii 11kg and barrenwort 12kg, add 15 Volumetric concentration is measured again for the alcohol reflux of 50-80% is extracted twice, each refluxing extraction 3 hours, filtration, merging filtrate, filtrate It is -0.08MPa in pressure, to be concentrated into medicinal extract at 65 DEG C, relative density of the gained medicinal extract in temperature 60 C is 1.3 to temperature；
3) weigh by step 1) pulverize and sieve after Psoralea corylifolia 8kg, fruit of Chinese wolfberry 7kg and mulberries 9kg, and date 7kg, 15 times of decocting is added to boil twice, 3 hours every time, filtration, merging filtrate, filtrate is 0.08MPa in vacuum, and temperature is 65 DEG C Under be concentrated into medicinal extract, relative density of the gained medicinal extract in temperature 60 C is 1.3；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, temperature be 80 DEG C, vacuum is 0.1MPa Under conditions of be vacuum dried to obtain dry extract, by the dry extract crush, cross 80 mesh sieves, it is standby；
5) by step 4) obtained by dry extract add starch 1kg, be well mixed, fill capsule, obtain final product；
6) by step 5) capsule that obtains is placed in capsule polisher and polishes, until capsule surface is bright and clean, does not glue powder.
In above-described embodiment 1-5, obtained capsule meets following technical requirements：
1st, product performance index
1.1 organoleptic indicators
The organoleptic indicator of table 1
1.2 effective component indexs
The physical and chemical index of table 2
1.3 physical and chemical indexs and sanitary index
The physical and chemical index of table 3
Project Index
Net content and content uniformity g, % 32,9
Disintegration time min 30
Lead (in terms of Pb) 1.5
Arsenic (in terms of As) mg/kg≤ 1.0
Mercury (in terms of Hg) mg/kg≤ 0.3
Moisture % ＜ 9.0
Ash content % ＜ 9.0
BHC mg/kg ＜ 0.1
DDT mg/kg ＜ 0.1
1.4 microbiological indicators
The microorganism qualitative change of table 4
2nd, the experiment of practical effect is confirmed
2.1：Experimental subjects and experimental facilities
Experimental subjects：For a long time in the brain worker crowd of office, they are for a long time in an environment for relative closure Middle activity, is easiest to cause fatigue due to ischaemia, measures its brain tissue pathological changes to reflect their degree of fatigue.
Experimental facilities：Developed using biomedical engineering system of Tsing-Hua University, the TSAH-100 of An Hengguang major companies production is near Infrared tissue oxygenation nondestructive testing instrument detects tissue oxygenation saturation, using the PM9000 degree multi-parameter physiologicals of Shenzhen MINDRAY Measuring instrument detects heart rate, respiratory rate and blood pressure.
2.2nd, experimental technique
We use two groups of experiments, are divided into 2 two parts of experiment 1 and experiment, and all experiments are all detected using double blinding.
Experiment 1：Subject includes the people of Healthy Youth 6, is divided into experimental group (TS groups), 3, male, age (23.7 ± 1.2) Year；Control group (CS groups) 3, male in year at age (23.7 ± 1.2), is all from the clerk of Shenzhen factory, experimental group Personnel take the anti-Fatigue Composition capsule that above-described embodiment 1 is obtained, and control group personnel take starch capsule；Then static In the case of measure the parameters such as the cerebral tissue oxygen saturation of subject, heart rate, respiratory rate, electrocardio and blood pressure, gathered every 1 minute One secondary data, records three secondary datas before capsule is taken, and six secondary datas are recorded after capsule is taken.The daily upper and lower noon respectively completes Once test, after every subject takes capsule, every measurement is received after 30min again, test continues 6 day time.
Experiment 2：Subject includes the people of Healthy Youth 6, is divided into experimental group (TS groups), 3, male, age (24.3 ± 5.5) Year；Control group (CS groups) 3, male in year at age (21.7 ± 1.5), is all from the clerk of Shenzhen factory, experimental group Personnel take the anti-Fatigue Composition capsule that above-described embodiment 1 is obtained, and control group personnel take instant coffee；Then static feelings The parameters such as brain tissue pathological changes, heart rate are measured under condition, a side data is gathered every 30s, record 10min.Do not take within first day Anti-Fatigue Composition capsule and instant coffee, are taken for subsequent three days, and test is arranged in the afternoon, and everyone takes the gained of embodiment 1 After anti-Fatigue Composition capsule/instant coffee, measurement is received again every 30min, test continues 3 day time.
2.3 data analyses
Test data carries out statistical analysis in SPSS15.0 analysis softwares.Test 1 experimental analysis subject and take capsule The change of the aspects such as front and rear brain tissue pathological changes, heart rate, respiratory rate, blood pressure.Dynamic experiment then stresses before analysis takes capsule Afterwards, change of the subject in terms of flesh oxygen saturation and exercise heart rate.Because all of experiment is all completed in a short time, because What this analysis result reflected is health food in a short time to the action effect of human body.
The data for testing 1 experimental analysis have：(1) overall test data (including brain tissue oxygen, heart rate etc.) mutation analysis, i.e., The test result that each subject's (experimental group, control group) (contained the upper and lower noon) within 6 day time is done one averagely, number is seen According to variation tendency；(2) morning measurement data (including brain tissue oxygen, heart rate etc.) mutation analysis, will each subject's (reality Test group, control group) test result in the morning does one averagely within 6 day time, sees the variation tendency of data；(3) measurement in afternoon Data (including brain tissue oxygen, heart rate etc.) mutation analysis, will each subject's (experimental group, control group) within 6 day time The test result in afternoon does one averagely, sees the variation tendency of data.
The data for testing 2 experimental analyses have：Measurement data (including brain tissue oxygen, heart rate etc.) mutation analysis, will be each Individual subject's (experimental group, control group) test result in afternoon within 4 day time does one averagely, sees the variation tendency of data.
Brain tissue saturation degree comparative result is tested in experiment 1
As shown in Fig. 2 by the analysis to data, finding TS groups subject and CS groups subject in blood pressure, heart rate, breathing There is no significant difference in rate, and concentration (rSO is closed in brain tissue oxygen2) change value on, have between test value and control group aobvious Write sex differernce (p<0.05), subject number TS1 in Fig. 2, TS2, what TS3 was represented is TS group subjects, CS1, CS2, CS3Represent CS group subjects.It is shown that subject's brain tissue oxygen of 6 days closes concentration (rSO2) average (including the measured value at upper and lower noon) exists The numerical value before and after capsule is taken, Fig. 3 represents the finger tip blood oxygen saturation (SpO of subject 6d2Concentration average (including the upper and lower noon Measured value) numerical value before and after capsule is taken.
As shown in Fig. 2 subject's brain tissue oxygen closes concentration in test in 6 days, TS groups subject is taking antifatigue combination After composite capsule, its brain tissue oxygen and concentration are generally what be increased, and CS groups subject is then without consistent sex expression.Compare Finger tip arterial oxygen saturation in tester 98% or so, its domain of walker<1%, there is no significant change.
As shown in figure 4, after the experiment for taking anti-Fatigue Composition capsule and instant coffee that the present invention implements 1 gained, The brain tissue pathological changes of subject have conspicuousness raising (p<0.05).Wherein the brain tissue oxygen content of TS groups subject is put down The brain tissue oxygen content that improve 22%, CS group subjects averagely improves 3.7%.
Shown by above analysis of experimental data, take the anti-Fatigue Composition capsule and coffee of the gained of the embodiment of the present invention 1 Coffee can reflect the anti-tired of the gained of the embodiment of the present invention 1 for the subject being engaged in mental work from brain tissue oxygen and concentration Labor composition capsule and coffee can play certain fatigue-relieving effect.
Experiment shows that the anti-Fatigue Composition capsule and coffee of the gained of the embodiment of the present invention 1 are conducive to strengthening blood-pumping function, From the point of view of experimental result, subject after the anti-Fatigue Composition capsule and coffee for taking the gained of the embodiment of the present invention 1, brain tissue Oxygen saturation rises, and now finger tip detecting sphygmus and blood oxygen saturation regulation leeway is limited, because finger tip pulse under normal conditions Blood oxygen up to 98% or so, the change value after anti-Fatigue Composition or coffee is taken<1%.Because the conveying of brain tissue oxygen also takes The function of certainly up being irrigated in arteria carotis, therefore the rise surface of brain tissue pathological changes cardiac function enhanced advantage is aobvious It is existing, be conducive to the transmission and absorption of blood oxygen so as to reflect anti-Fatigue Composition capsule and coffee.
2.4th, the antifatigue effect of the embodiment of the present invention 2, embodiment 3 and the gained anti-Fatigue Composition of embodiment 4
Method of testing test embodiments of the invention 2, embodiment 3 and implementation according to the above-mentioned test embodiment of the present invention 1 The antifatigue effect of the anti-Fatigue Composition of example 4, test result is：Subject is taking the embodiment of the present invention 2, the and of embodiment 3 After the anti-Fatigue Composition capsule of the gained of embodiment 4, brain tissue pathological changes rise, and heart rate is normal, and now finger tip pulse blood Oxygen saturation regulation leeway is limited, because finger tip pulse blood oxygen is antifatigue taking up to 98% or so under normal conditions Composition capsule change value<1%.Because the conveying of brain tissue oxygen additionally depends on the function that arteria carotis is up irrigated, therefore brain group Knit rise surface the manifesting of the enhanced advantage of cardiac function of oxygen saturation, it is favourable so as to reflect anti-Fatigue Composition capsule In the transmission and absorption of blood oxygen, i.e., anti-Fatigue Composition of the invention has good anti-fatigue effect.
More than, the only present invention preferably specific embodiment, but the protection domain of invention is not limited thereto, any ripe Know those skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in should all be contained Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be defined by the protection domain of claims.

Claims (10)

1. a kind of anti-Fatigue Composition, it is characterised in that it contains following component by weight percentage：Rhodiola root 15-45%, Wilsonii 5-25%, barrenwort 10-30%, Psoralea corylifolia 8-20%, fruit of Chinese wolfberry 3-18%, mulberries 5-20%, date 2-8%, form sediment Powder 0.3-1.2%.
2. anti-Fatigue Composition according to claim 1, it is characterised in that its by weight percentage containing it is following into Point：Rhodiola root 20-40%, wilsonii 10-20%, barrenwort 10-25%, Psoralea corylifolia 8-18%, fruit of Chinese wolfberry 5-15%, mulberries 6- 18%, date 3-7%, starch 0.5-1.0%.
3. anti-Fatigue Composition according to claim 1 and 2, it is characterised in that red in antifatigue combination described in per 100g The content of red-spotted stonecrop glucoside is not less than 72mg, and the content of Thick many candies is not less than 200mg；And the water content of the anti-Fatigue Composition≤ 9.0wt%.
4. the preparation method of the anti-Fatigue Composition according to any one of claims 1 to 3, it is characterised in that including such as Lower step：
1) by rhodiola root, wilsonii, barrenwort, Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, pulverizer crushing is separately added into, crosses 40-80 mesh Sieve, takes sieving standby；
2) the step of weighing formula ratio 1) in rhodiola root, wilsonii and barrenwort, it is 50- to add the 5-15 times of volumetric concentration measured 80% alcohol reflux is extracted more than twice, each refluxing extraction 1-3 hours, and filtration, merging filtrate, filtrate is concentrated into medicinal extract；
3) the step of weighing formula ratio 1) in Psoralea corylifolia, the fruit of Chinese wolfberry and mulberries, date adds 6-15 times of decocting to boil at least two Secondary, each 1-3 hours, filtration, merging filtrate, filtrate is concentrated into medicinal extract；
4) by step 2) and step 3) obtained by medicinal extract merge, stir, temperature be 60-80 DEG C, vacuum is 0.04- Dry extract is vacuum dried to obtain under conditions of 0.1MPa, the dry extract is crushed, sieving takes sieving standby；
5) by step 4) obtained by dry extract add formula ratio starch, be well mixed, fill capsule, obtain final product described antifatigue group Compound.
5. preparation method according to claim 4, it is characterised in that step 2) described in the condition that concentrates be：Vacuum 0.07-.08MPa, 60-65 DEG C of temperature.
6. preparation method according to claim 5, it is characterised in that step 3) described in the condition that concentrates be vacuum 0.07-0.08MPa, 60-65 DEG C of temperature.
7. preparation method according to claim 6, it is characterised in that step 2) described in phase of the medicinal extract at 55-60 DEG C It is 1.1-1.3 to density.
8. preparation method according to claim 7, it is characterised in that step 3) described in phase of the medicinal extract at 55-60 DEG C It is 1.1-1.3 to density.
9. preparation method according to claim 8, it is characterised in that step 4) mesh number of gained dry extract is 60-80 mesh.
10. the preparation method according to any one of claim 4~9, it is characterised in that also including by step 5) obtain Capsule is placed in capsule polisher and polishes, until capsule surface is bright and clean, does not glue powder.
CN201611149628.3A 2016-12-13 2016-12-13 A kind of anti-Fatigue Composition and preparation method thereof Pending CN106728368A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107281320A (en) * 2017-07-21 2017-10-24 安徽全康药业有限公司 A kind of energy filling liver kidney, benefiting essence-blood, antifatigue, radiation proof Chinese medicinal composition capsules agent preparation method
CN117379490A (en) * 2023-12-11 2024-01-12 南昌大学 Traditional Chinese medicine composition for improving blood oxygen saturation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
郭建生等: "《保健品与亚健康》", 31 May 2009, 中国中医药出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107281320A (en) * 2017-07-21 2017-10-24 安徽全康药业有限公司 A kind of energy filling liver kidney, benefiting essence-blood, antifatigue, radiation proof Chinese medicinal composition capsules agent preparation method
CN117379490A (en) * 2023-12-11 2024-01-12 南昌大学 Traditional Chinese medicine composition for improving blood oxygen saturation

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Application publication date: 20170531