CN106727982A - It is a kind of to treat Chinese medicine composition of anxiety disorder and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of anxiety disorder and preparation method thereof Download PDFInfo
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- CN106727982A CN106727982A CN201710092971.7A CN201710092971A CN106727982A CN 106727982 A CN106727982 A CN 106727982A CN 201710092971 A CN201710092971 A CN 201710092971A CN 106727982 A CN106727982 A CN 106727982A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
It is specifically a kind of to treat Chinese medicine composition of anxiety disorder and preparation method thereof the present invention relates to key areas.It is made up of the raw material of following parts by weight：20~40 parts of lotus seeds, 10~20 parts of Sculellaria barbata, 10~20 parts of Chinese lobelia, 10~20 parts of Herba Andrographitis, 5~10 parts of santal.Compared with the existing technology, simple production process, low production cost, implementation are strong, it is easy to large-scale industrial production for the present invention；Dose is small, convenient to take, and can preferably ensure medicine stability and effect；For treating anxiety disorder effect is significant, Small side effects can long-term taking.
Description
Technical field
It is specifically a kind of to treat Chinese medicine composition of anxiety disorder and preparation method thereof the present invention relates to key areas.
Background technology
Anxiety disorder, is also called anxiety neurosis, is a most common class in neurosis, and anxiety disorder can be divided into chronic anxiety
With two kinds of forms of AAA, i.e. generalized anxiety disorder and panic disorder.According to World Health Organization's mental health
Data, anxiety disorder can influence 16% population.China has most carried out spiritual disease earlier than nineteen eighty-two in national 12 areas
The epidemiology survey of disease, in 15~59 years old crowd, the illness rate of anxiety disorder is 1.48 ‰, accounts for neurosis case
6.7%.The meta-analysis of Chinese general population's Prevalence of Anxiety Disorders in recent years shows that the point prevalence of anxiety disorder is
1.0%, lifetime prevalence is 3.2%, and wherein the point prevalence of generalized anxiety disorder is 0.6%, and panic disorder is 0.2%.
The height of the illness rate of anxiety disorder, the influence that symptom is lived after occurring to people is big, and the pain of anxiety patient is to be caused deeply
The attention of many scholars.Therefore, understand the pathogenic process of anxiety disorder in depth, find effective prevention and treatment measure to mitigate disease
The pain and burden that disease brings then seem most important.
The cause of disease and pathogenesis of anxiety disorder do not understand that the generation and heredity of anxiety disorder are thought in most of researchs still at present
, neuroimaging, Neurobiology are related to socio-psychological factor etc..
Current clinical practice drug treatment is still one for the treatment of anxiety disorder most common method.Many researchs before are
Confirming Clonazepam, diazepam, the benzodiazepine such as alprazolam has a good angst resistance effect, but such medicine
Thing is easily caused the adverse reactions such as sleepy, hepatic disorder, and long-term use easily forms dependence, tolerance, withdrawal reaction etc., therefore makes it
With being restricted, therefore normal short application use in clinic.Explore application side effect it is relatively light, can again will not be right with prolonged application
Patient causes the medicine of serious adverse consequences to substitute benzene nitrogen Zhuo class medicine, as pendulum need to face in face of clinician it is new
Problem.
Volt disease learn think, anxiety disorder is wet poison factor abnormal aggregation body, disturb adrenal gland energy hormone stress reaction and
Persistent state, causes a kind of common neurosis based on anxiety.
This new knowledge has two break-through points, and it is to cause the basic reason of anxiety that one highlights wet poison environment；Another
The change of the stress reaction and persistent state of adrenal gland energy hormone is specified, is the pathologic basis of anxiety.According to this new knowledge, I
The preventing and treating of anxiety disorder should also be set about from these two aspects.First it is to remove internal wet poison environment, is only afterwards on adjustment kidney
Expression status and form in parathyrine energy body.
Wet poison environment is that hollow organ field planting bacterium is largely downright bad, and field planting bacterium cellular content is excessive, and DNA or plasmid degraded are not
Fully, combined with body or intake free protein, caused active change foreign substances, caused the inflammation of localized sustained and be immunized
Reactiveness, the related hypothalamic-pituitary-adrenal signal path of activation inflammation（hypothalamic-pituitary-
Adrenal, HPA）, the stress reaction and normal secretions stable state of adrenal gland energy hormone are disturbed, cause sympathetic nerve-adrenal gland system different
Often regulation and control, autonomic nervous dysfunction, and then influence HPA stabilizations.
Especially wet poison factor invasion and attack gallbladder channel, enters Liver Channel, causes liver dysfunction, causes anxiety.Have confirmed, gall-bladder is smoothed
There are adrenergic α and beta receptor on flesh, smooth muscle of bile vesica motion is relevant with adrenal gland energy hormone.
The content of the invention
The present invention designs a kind of Small side effects to overcome the deficiencies in the prior art, and therapeutic effect significantly treats anxiety disorder
Chinese medicine composition and preparation method thereof.
To achieve the above object, a kind of Chinese medicine composition for treating anxiety disorder is designed, it is characterised in that by following weight portion
Several raw materials are made：20~40 parts of lotus seeds, 10~20 parts of Sculellaria barbata, 10~20 parts of Chinese lobelia, 10~20 parts of Herba Andrographitis, santal 5
~10 parts.
The lotus seeds, Sculellaria barbata, Chinese lobelia, Herba Andrographitis, santal are its water extract or extractive with organic solvent.
A kind of preparation method of the Chinese medicine composition for treating anxiety disorder, it is characterised in that including following preparation process：
Step 1, takes Sculellaria barbata, the santal of the parts by weight, soak and then it is heated to reflux 2 0.5~1 hour~
3 times, 1~3 hour every time, volatile oil is collected, volatile oil adds microcrystalline cellulose, is well mixed, and obtains volatile oil figuration powder,
Liquid is filtered while hot, and filtrate merges, and obtains a filtrate；
Step 2, takes lotus seeds, Chinese lobelia, the Herba Andrographitis of the parts by weight, then adds water to cook 2 times, first time 0.5~2
Hour, second 1~3 hour, filtration obtained No. two filtrates；
Step 3, a filtrate and No. two filtrates are merged, and with organic solvent filtering and concentrating, reclaim organic solvent, 25 DEG C~
It is condensed into thick paste in the case of 60 DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
Concentration condition in the step 3 is 1.08~1.28 to be concentrated into relative density, adds ethanol to make containing alcohol
Measure is 50~70%.
Diluent, lubricant, adhesive, disintegrant, sweetener, stabilizer, anti-is added in the Chinese medicinal composition preparation
One or more mixture in rotten agent etc..
Described Chinese medicinal composition preparation is the one kind in pulvis, tablet, granule, capsule, soft capsule, spray.
Compared with the existing technology, simple production process, low production cost, implementation are strong, it is easy to large-scale industry for the present invention
Metaplasia is produced；Dose is small, convenient to take, and can preferably ensure medicine stability and effect；For treating anxiety disorder effect
Significantly, Small side effects, can long-term taking.
Specific embodiment
Heretofore described diluent includes but is not limited to lactose, starch, microcrystalline cellulose, mannitol etc.；Described
Lubricant includes but is not limited to magnesium stearate, talcum powder etc.；Described adhesive includes but is not limited to polyethylene Topiramate Los oxazolidinone, hydroxyl
Propyl cellulose etc.；Described disintegrant includes but is not limited to carboxymethylcellulose calcium, acetic acid carboxy starch sodium, PVPP
Deng；Described sweetener includes but is not limited to sucrose, fructose, D-sorbite etc.；Described stabilizer includes but is not limited to carboxylic first
Base sodium cellulosate, cyclodextrin, xanthans etc.；Described preservative includes but is not limited to potassium sorbate, nipagin esters etc..
Embodiment one：
Sculellaria barbata 10g, santal 5g are taken, 0.5 hour is soaked and then is heated to reflux 3 times, 3 hours every time, collect volatilization
Oil, volatile oil adds microcrystalline cellulose, is well mixed, and obtains volatile oil figuration powder, and liquid is filtered while hot, and filtrate merges, and obtains one
Number filtrate.
Lotus seeds 20g, Chinese lobelia 20g, Herba Andrographitis 20g are weighed again, are then added water to cook 2 times, 0.5 hour for the first time, the
Secondary 1.5 hours, filtration obtained No. two filtrates.
Finally merge a filtrate and No. two filtrates, with organic solvent filtering and concentrating, organic solvent is reclaimed, at 50 DEG C
In the case of be condensed into thick paste, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, and is made particle, is done
Dry, whole grain, packaging obtains final product Chinese medicinal composition preparation.
Wherein method for concentration can be using the conventional method such as vacuum concentration or normal temperature be concentrated under reduced pressure.Drying means can be used
The conventional method such as spray drying or freeze-drying.The method that filtrate and residue are separate can be using filtering or centrifugation etc. often
Rule method.
Embodiment two：
Sculellaria barbata 15g, santal 6g are taken, 1 hour is soaked and then is heated to reflux 2 times, 1.5 hours every time, collect volatilization
Oil, volatile oil adds microcrystalline cellulose, is well mixed, and obtains volatile oil figuration powder, and liquid is filtered while hot, and filtrate merges, and obtains one
Number filtrate.
Lotus seeds 30g, Chinese lobelia 15g, Herba Andrographitis 15g are weighed again, is then added water to cook 2 times, for the first time 1 hour, second
Secondary 2 hours, filtration obtained No. two filtrates.
Finally merge a filtrate and No. two filtrates, with organic solvent filtering and concentrating, organic solvent is reclaimed, at 60 DEG C
In the case of be condensed into thick paste, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, and is made particle, is done
Dry, whole grain, packaging obtains final product Chinese medicinal composition preparation.
Embodiment three：
Sculellaria barbata 20g, santal 10g are taken, 1 hour are soaked and then is heated to reflux 3 times, 2 hours every time, collect volatile oil,
Volatile oil adds microcrystalline cellulose, is well mixed, and obtains volatile oil figuration powder, and liquid is filtered while hot, and filtrate merges, and obtains a filter
Liquid.
Lotus seeds 20g, Chinese lobelia 10g, Herba Andrographitis 10g are weighed again, is then added water to cook 2 times, for the first time 1 hour, second
Secondary 3 hours, filtration obtained No. two filtrates.
Finally merge a filtrate and No. two filtrates, with organic solvent filtering and concentrating, organic solvent is reclaimed, at 25 DEG C
In the case of be condensed into thick paste, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, and is made particle, is done
Dry, whole grain, packaging obtains final product Chinese medicinal composition preparation.
Model case：
Select 80 patients for being diagnosed as anxiety disorder, wherein man 43, female 37, the age between 15 to 55 years old, the course of disease 1 to 20
Year.80 patients are randomly divided into treatment group 40, control group 40, and between two groups the data such as age there was no significant difference.
Particle obtained in embodiment one in the oral present invention for the treatment of group, boiling water is taken after mixing it with water, and one time 15,2 times a day, the course for the treatment of 7 days；
The oral ALprazolanic of control group：Two times a day, each 0.4mg.The course for the treatment of 7 days.Treatment group and control group observation item include：Treatment
Front and rear mood is irritable, nervous, fear, frightened, dizzy, dizzy, uncomfortable in chest, palpitaition, expiratory dyspnea, dry, frequent micturition, perspire, tremble,
The symptoms such as motion uneasiness.
| Group | N | Cure | Take a turn for the better | It is invalid | Total effective rate | Adverse reaction |
| Treatment group | 42 | 22（52.4%） | 16（38.1%） | 4（9.5%） | 90.5% | 0 |
| Control group | 38 | 0（0%） | 28（73.7%） | 10（26.3%） | 73.7% | 20 |
Upper table is the treatment statistics for the treatment of group and control group, wherein the standard cured is clinical symptoms all disappear,
Laboratory examination is normal；The standard of improvement is clinical symptom relief, and laboratory examination improves or normal；Invalid standard is clinic
Symptom is without being clearly better or aggravate.
As seen from the table, the obtained medicine of the present invention can safely and effectively treat anxiety disorder.
Claims (6)
1. a kind of Chinese medicine composition for treating anxiety disorder, it is characterised in that be made up of the raw material of following parts by weight：Lotus seeds 20~
40 parts, 10~20 parts of Sculellaria barbata, 10~20 parts of Chinese lobelia, 10~20 parts of Herba Andrographitis, 5~10 parts of santal.
2. a kind of Chinese medicine composition for treating anxiety disorder as claimed in claim 1, it is characterised in that：The lotus seeds, Sculellaria barbata,
Chinese lobelia, Herba Andrographitis, santal are its water extract or extractive with organic solvent.
3. a kind of a kind of preparation method of the Chinese medicine composition for treating anxiety disorder as claimed in claim 1, it is characterised in that bag
Include following preparation process：
Step 1, takes Sculellaria barbata, the santal of the parts by weight, soak and then it is heated to reflux 2 0.5~1 hour~
3 times, 1~3 hour every time, volatile oil is collected, volatile oil adds microcrystalline cellulose, is well mixed, and obtains volatile oil figuration powder,
Liquid is filtered while hot, and filtrate merges, and obtains a filtrate；
Step 2, takes lotus seeds, Chinese lobelia, the Herba Andrographitis of the parts by weight, then adds water to cook 2 times, first time 0.5~2
Hour, second 1~3 hour, filtration obtained No. two filtrates；
Step 3, a filtrate and No. two filtrates are merged, and with organic solvent filtering and concentrating, reclaim organic solvent, 25 DEG C~
It is condensed into thick paste in the case of 60 DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
4. the preparation method of a kind of Chinese medicine composition for treating anxiety disorder as stated in claim 3, it is characterised in that：The step
Concentration condition in rapid 3 is 1.08~1.28 to be concentrated into relative density, add ethanol make alcohol content for 50~
70%.
5. the preparation method of a kind of Chinese medicine composition for treating anxiety disorder as stated in claim 3, it is characterised in that：In described
The one kind in diluent, lubricant, adhesive, disintegrant, sweetener, stabilizer, preservative etc. is added in drug composition preparation
Or more than one mixture.
6. the preparation method of a kind of Chinese medicine composition for treating anxiety disorder as stated in claim 3, it is characterised in that：Described
Chinese medicinal composition preparation is the one kind in pulvis, tablet, granule, capsule, soft capsule, spray.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710092971.7A CN106727982A (en) | 2017-02-21 | 2017-02-21 | It is a kind of to treat Chinese medicine composition of anxiety disorder and preparation method thereof |
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| CN201710092971.7A CN106727982A (en) | 2017-02-21 | 2017-02-21 | It is a kind of to treat Chinese medicine composition of anxiety disorder and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526546A (en) * | 2012-01-04 | 2012-07-04 | 田胜利 | Chinese medicinal composition and preparation and preparation method thereof |
| CN102949513A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medical health protection product for alleviating anxiety neurosis and preparation method thereof |
| CN106266730A (en) * | 2016-08-08 | 2017-01-04 | 青岛友诚高新技术有限公司 | One treats emophysematous Chinese medicine composition and preparation method thereof |
-
2017
- 2017-02-21 CN CN201710092971.7A patent/CN106727982A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526546A (en) * | 2012-01-04 | 2012-07-04 | 田胜利 | Chinese medicinal composition and preparation and preparation method thereof |
| CN102949513A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medical health protection product for alleviating anxiety neurosis and preparation method thereof |
| CN106266730A (en) * | 2016-08-08 | 2017-01-04 | 青岛友诚高新技术有限公司 | One treats emophysematous Chinese medicine composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 田胜利、何春梅: "《伏病论》", 30 June 2015 * |
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