CN104000920A - Traditional Chinese medicine preparation for treating pain diseases or arthralgia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating pain diseases or arthralgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating pain diseases or arthralgia and a preparation method thereof. The traditional Chinese medicine preparation is prepared from traditional Chinese medicines of periploca forrestii schltr, nothapodytes pittosporoides, asiatic toddalia roots, radix psammosilenes, herba chloranthi serrate, cinnamomum camphora roots, radix gaultheriae, and borneolum luodian, zanthoxylum oil, polyvinyl formal-acetal, and 75% ethanol. The traditional Chinese medicine preparation of the invention has the efficacy of dispelling wind and eliminating dampness, and activating meridians to stop pain. Plastics of the preparation of the invention can treat arthralgia; since the medicine acts on the focus directly and continuous and high-efficient medicine release is carried out, the plastics are more effective and safer than medicines for oral administration, and have advantages in arthralgia treatment.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation for the treatment of pain disease or arthromyodynia and preparation method thereof.
Background technology
Epidemiological study shows, 80% adult is the light or heavy puzzlement that is subject to lumbago and skelalgia early or late, the Jin U.S., and annual medical treatment and economic loss expense reach 1,600,000,000.Due to illness about 2% lumbago patient leaves office.At present, China lumbago patient rejuvenation gradually, number of patients increases year by year, has a strong impact on China citizen's work and quality of life, at south China wind-cold damp pathogen, is mingled with, and 95% above lumbago patient all belongs to arthromyodynia according to incompletely statistics.The western medical treatment of lumbago arthromyodynia is except using nonsteroidal anti inflammatory analgesic, immunosuppressant treatment, there is no specific medicament, and there is larger side effect in oral drugs, though Chinese traditional treatment means are many at present, but without definite curative effect evaluation of clinical curative effect, differ, still do not form the unified standard of lumbago arthromyodynia treatment at present.
Liniment is a kind of Novel external dosage form, and current liniment is studied also fewer abroad, also finds no the report of liniment treatment arthromyodynia at present.At home, liniment is treated the less of arthromyodynia, and the report with liniment for arthromyodynia is not found in literature search over nearly 10 years.The Therapeutic Method of arthromyodynia is more, its evaluation of clinical curative effect differs, still do not form at present the unified standard of arthromyodynia treatment, along with medical science, industry and scientific and technical development, exploitation transdermal penetration Chinese medicine external liniment high, rapid-action, that effect is lasting, curative effect is sure, side effect is little and with strong points is the direction that we make great efforts from now on.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of have good expelling wind and removing dampness, the effect of removing obstruction in the collateral to relieve pain, in treatment lumbago arthromyodynia, curative effect is affirmed, overcome percutaneous drug delivery barrier, promotion medicine within a certain period of time transdermal penetration reaches the treatment pain disease of therapeutic dose or Chinese medicine preparation of arthromyodynia and preparation method thereof.
In order to solve the problems of the technologies described above, the present invention adopts following technical scheme:
It is to add that by raw material of Chinese medicine Heiguteng exract 100～200g, Lysimachia trientaloides Hemsl. 100～200g, Radix Toddaliae Asiaticae 70～150g, Radix Psammosilenes 70～150g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 70～150g, Radix Cinnamomi Camphorae 70～150g, Caulis et folium gaultheriae yunnanensis 70～150g, Blumeae preparatum Tabellae 5～20g contract first and second aldehyde 70～150g, 75% ethanol 20～50ml of Fructus Zanthoxyli oil 10～30g, polyethylene is prepared from.
Be preferably: it is to add that by raw material of Chinese medicine Heiguteng exract 150g, Lysimachia trientaloides Hemsl. 150g, Radix Toddaliae Asiaticae 100g, Radix Psammosilenes 100g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 100g, Radix Cinnamomi Camphorae 100g, Caulis et folium gaultheriae yunnanensis 100g, Blumeae preparatum Tabellae 15g contract the first and second aldehyde 100g, 75% ethanol 30ml of Fructus Zanthoxyli oil 20g, polyethylene is prepared from.
The preparation method of the Chinese medicine preparation of aforementioned therapies pain disease or arthromyodynia:
By Heiguteng exract, Lysimachia trientaloides Hemsl., Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis seven flavor medicine, add 10 times of amount water boiling and extraction 3 times at every turn, each decoction 1 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.12-1.16 (80 ℃), adds ethanol and makes medicinal liquid contain alcohol amount to reach 75%; Add polyvinyl formal-acetal, add after 75% soak with ethanol expansion, it is dissolved completely, stir evenly standby; After alcohol deposit fluid is added to Blumeae preparatum Tabellae and Fructus Zanthoxyli oil, stir with substrate, add 75% ethanol and adjust total amount to 1000g, obtain.
effect of the present invention:expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
trade name of the present invention: firkin dispel pain liniment;
Main component of the present invention is Heiguteng exract, Lysimachia trientaloides Hemsl., Rhizoma Drynariae, Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis, Blumeae preparatum Tabellae, Fructus Zanthoxyli oil composition.Heiguteng exract, Lysimachia trientaloides Hemsl. nature and flavor are pungent, and temperature, belongs to gunpowder, have that the meridian dredging, wind dispelling are wet, cold expelling qigong effect be take expelling wind and removing dampness, the cold expelling of regulating the flow of vital energy as principal agent; Ground Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis nature and flavor are pungent, and temperature, belongs to gunpowder, and having expelling wind and removing dampness, eliminating stasis to stop pain, promoting blood circulation to remove obstruction in the collateral is ministerial drug; Assistant helps that principal agent is played expelling wind and removing dampness altogether, the merit of the cold expelling of regulating the flow of vital energy; Blumeae preparatum Tabellae is arduous, warm, the key stagnated fire of faling apart, reducing swelling and alleviating pain; Pericarpium Zanthoxyli nature and flavor are pungent, and large heat belongs to the gunpowder of prosperity, warming middle-JIAO to relieve pain, dispelling cold and removing dampness.All medicines are all in accordance with master, minister, auxiliary Shui nationality medicine combination principle above, and prescription is rigorous, and cautiously grasping pathogenesis, for evil side, the effect of playing altogether expelling wind and removing dampness, removing obstruction in the collateral to relieve pain are attacked in external.Liniment treatment arthromyodynia, due to medicine direct effect focus, and continues efficient administration, and compared with oral medicine is more effective, safety has advantage to the treatment of arthromyodynia.
Prescription of the present invention is to take the extreme misery theory of Shui nationality medicine to be basis, the Shui nationality doctor replace according to life, the fluctuation of variation and river round the clock, having summed up Yi Shui and fire is the things attribute of outline, thinks: every have flow downward, liquid, passive, sombrely dark, static things is mostly aqueous; Every rising, sunlight, bright, warm, the changeable bad temper that belongs to, has tentatively produced the concept of negative and positive.Hydrothermal coordination, all things on earth is gentle; Extreme misery imbalance, all things on earth damages mutually; Extreme misery specific object shows as extreme misery, and clinical card marquis shows extreme misery, and rule for the treatment of Heibei provincial opera extreme misery is corrected prosperity and decline.The Shui nationality people are divided into gunpowder, the large class of water medicine two medicine.Principle of medication is calentura water medicine, cold disease gunpowder.In medicinal flavor classification, acrid in the mouth, temperature, sweet, numb, fragrant, peppery medicine belong to gunpowder; Cold, cool, sour, puckery, bitter, the salty genus water of all nature and flavor medicine.The diagnosis and treatment of Shui nationality medicine bone injury take extreme misery unbalance be core theory, card marquis shows extreme misery, rule for the treatment of Heibei provincial opera extreme misery is corrected prosperity and decline, depending on the heart upper be sun, kidney lower be the moon.The state of water is cold and cool, and traffic direction is descending, and pictograph is water, and what internal organs were corresponding is kidney; The state of fire is hot, and traffic direction is up, and pictograph is fire, and what internal organs were corresponding is heart.Arthromyodynia is a kind of commonly encountered diseases, frequently-occurring disease, and arthromyodynia patient is large, and multipair Changes in weather is more responsive, cloudy, rainy, cold, moist etc., and climate change all can be caused a disease or aggravate disease.And arthromyodynia morbidity domain of the existence, seasonality, regularity, the Shui nationality people live in subtropical zone mostly, overcast and rainy many, humid environment, and the temperature difference is large sooner or later, economical relatively backward, is the district occurred frequently of arthromyodynia.The Shui nationality people, in the process that very long and this disease are resisted, have accumulated rich experience, have dense national characters.Numbness, i.e. numbness resistance is obstructed.Arthromyodynia refer to human body machine table, meridians because of experience that wind, cold, wet, heat etc. cause with limbs joint and muscular soreness, numbness, weighing, joint stuffiness, even the class disease that the scorching hot grade of arthroncus is primary symptom.Main pathogenesis is that the resistance of QI and blood numbness is obstructed, and lose due to moisten and support in muscle arteries and veins joint.Shui nationality medicine thinks that arthromyodynia belongs to diseases caused by retention of the body fluid (cold sick), and treatment adopts gunpowder mostly.Therapeutic Principle is " with fire, controlling cold ".
[quality of medicinal material standard];
1. Heiguteng exract this product is asclepiadaceae plant Caulis et Radix Periplocae Forrestii
periploca forrestiischltr. dry root or Herb.Quality standard is referring to < < Guizhou Province Chinese crude drug, 2003 editions " Heiguteng exract " lower regulations of national quality of medicinal material standard > >.
2. Lysimachia trientaloides Hemsl. this product is to be root or the herb of Ofthe Primulaceae Lysimachia trientaloides Hemsl. Primuleae.Quality standard is referring to < < Guizhou Province Chinese crude drug, 2003 editions " Lysimachia trientaloides Hemsl. " lower regulations of national quality of medicinal material standard > >.
3. Radix Toddaliae Asiaticae this product is rutaceae Radix Toddaliae Asiaticae
toddalia asiatica(L.) the dry root bark of Lam..Quality standard is referring to < < Guizhou Province Chinese crude drug, 2003 editions " Radix Toddaliae Asiaticae root bark " lower regulations of national quality of medicinal material standard > >.
4. Radix Psammosilenes this product is pinkwort Radix Psammosilenes
psammosilene tunicoidesthe dry root of W.C.Wu et C.Y.Wu.Excavate autumn, removes crust and impurity, dries.
Quality standard is referring to 2010 editions one " Radix Psammosilenes " lower regulations of < < Chinese Pharmacopoeia > >.
5. Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) this product is Chloranthaceae plant Radix Chloranthi Serrati
chloranthus serratusroem.et Schulte., Chloranthus multistachys
chloranthus multistachys(H.-M.) Pei, silk fringe chu lan tree
chloranthus fortunei(A.Gray) Solma. and wide leaf Chloranthus spicatus
chloranthus heuryihemsl. dry rhizome and root.Quality standard is referring to < < Guizhou Province Chinese crude drug, 2003 editions " Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) " lower regulations of national quality of medicinal material standard > >.
6. Radix Cinnamomi Camphorae this product is canella Camphor tree
cinnamomum camphora(L.) the dry tree root of Presl.Spring, Qiu Erji excavate, and clean, and section, dries.Quality standard is referring to < < Guizhou Province Chinese crude drug, 2003 editions " Radix Cinnamomi Camphorae " lower regulations of national quality of medicinal material standard > >.
7. Caulis et folium gaultheriae yunnanensis is ericad Yunnan Gaultheria Gaultheriayunnanensis(Franch.) Rehd stem and leaf.Quality standard is referring to < < Guizhou Province Chinese crude drug, 2003 editions " Caulis et folium gaultheriae yunnanensis " lower regulations of national quality of medicinal material standard > >.
8. Blumeae preparatum Tabellae this product is feverfew Herba Blumeae Balsamiferae
blumea balsamifera(L.) fresh leaf of DC. is through extracting the crystallization of being processed into.Quality standard is referring to 2010 editions one " Blumeae preparatum Tabellae " lower regulations of < < Chinese Pharmacopoeia > >.
clinical data;
1.1 physical dataall cases are closure pain disease or arthromyodynia.
1.2 diagnostic criteriaall closure pain disease or arthromyodynias, doctor independently diagnoses, itemized record main suit and medical history.Or the following disease of reference treatment: acute and chronic bruise, rheumatic arthritis, rheumatoid arthritis, gout, scapulohumeral periarthritis, the limbs joint pain and swelling of caused by hyperosteogeny, and nervous headache.
1.3 inclusive criteria(1) meet above-mentioned diagnostic criteria person; (2) 18～65 years old age; (3) voluntarily as study subject, and energy reception test pharmaceutical dosage form, person's course for the treatment of guaranteed.
1.4 exclusion standard(1) do not meet above-mentioned Western medicine diagnose standard or TCM syndrome diagnostic criteria person; (2) age is under-18s and over-65s person; (3) used the medicine person of other treatment primary disease; (4) allergic constitution or to forming the known composition allergy sufferers of this medicine;
(5) be associated with the serious primary disease person of cardiovascular, cerebrovascular, Liver and kidney and hemopoietic system; (6) be associated with fracture, dislocation, important blood vessels, nerve injury person; (7) skin injury, skin eczema, or struvite infection causes pain, redness, the symptom such as livid purple; (8) flesh is good for, ligament rapture need be gone repairing patient.Possessing above any 1 person gets rid of.
1.5 stop research standard(1) in experiment, fail to adhere to by doctor's advice medication or use voluntarily other drug therapist instead; (2) in experiment, occur that local skin discomfort can not continual cure person; (3) there is serious adverse events; (4) in clinical trial process, there is serious other complications person.
2 research methoies;
2.1 Therapeutic Method;
2.1.1 groupingthis research adopts the method for clinical randomized controlled trial test, according to medical sequencing, is divided at random firkin drives pain liniment treatment group and matched group with table of random number method, carries out clinical observation on the therapeutic effect.Experimental group: 93 examples, matched group: 60 examples.
2.1.2 Therapeutic Method(1) experimental group: evenly spread upon patient's sore place with cotton swab after firkin is driven to logical liniment heating for dissolving, smear again after 10 minutes a time, this method operation 3 times; Every day 3 times.Matched group is used XUESHANJINLUOHAN ZHIOTNG TUMOJI as positive control, smears one time this method operation 3 times after 10 minutes again; Every day 3 times.Observe and record before treatment, treat the 1st, 3,7, if the clinical symptoms change situation of 14 days and skin irritation situation. there is local untoward reaction, give immediately respective handling or discontinue medication, and give record.Treating the course for the treatment of is 14 days.
2.2 observation index and evaluation criteria;
2.2.1. safety observation;
Before medication and when the course for the treatment of finishes, each detects once, as there is the abnormal of test index in process of the test, should check to normally.
(1) general physical examination;
(2) three is large conventional;
(3) renal function (blood urea nitrogen, creatinine), liver function (glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT), blood pressure, electrocardiogram;
(4) untoward reaction that may occur: patient's private prosecution untoward reaction (as dizzy, uncomfortable in chest etc.) and dermoreaction are observed (rubescent, itch, pimpling).
2.2.2 clinical symptoms integration(1) pain measurement: adopt visual analogue scales (VAS) to judge patient's pain intensity.Visual analogue scales (Visual Analogue Scale/Score is called for short VAS); This method is sensitiveer, has comparability.Specific practice is: the horizontal line of standardized 10cm on paper, and one end of horizontal line is 0, represents painless; The other end is 10, represents severe pain; Mid portion represents pain in various degree.Allow patient experience according to the oneself of pain in following grade, select corresponding score value to beat √ and make marks.
(regulation 0 is as painless, and 1～3 is mild pain, and 4～7 is moderate pain, and 8～10 is severe pain to adopt visual analogue scales (VAS) to judge pain intensity.)。1. normal: when VAS is 0 tranquillization and when movable all without pain; 2. slight: painless when VAS is 1～3 tranquillization, mild pain during the normal activity of mouth; Mild pain when 3. moderate: VAS is 4～7 tranquillization, during the normal activity of mouth, pain increases the weight of; Sharp ache when 4. severe: VAS is 8～10 tranquillization or when mouthful normal movable.(2) symptom and sign integration: A. pain integration method evaluation.1. normal: 0 minute without pain; 2. slight: within 1 minute, hypodynia discomfort does not affect activity; 3. moderate: pain was heavier in 2 minutes; 4. severe: 3 minutes hurt like hells; 5. serious: 4 minutes severe pain unbearably, is lain awake all night.B. tenderness integration method evaluation: 1. normal: 0 minute without tenderness; 2. slight: 1 minute not obvious, dark pressure can be bitterly; 3. moderate: tenderness was obvious in 2 minutes; 4. severe: 3 minutes light tenderness very; 5. serious: the severe pain of touching for 4 minutes, tenderness.C. dysfunction integration method evaluation: 1. normal: 0 minute is not limited;
2. slight: within 1 minute, function is not limited, slightly uncomfortable during conscious activity; 3. moderate: active movement in 2 minutes is slightly limited, passive activity pain; 4. severe: 3 minutes obvious limitation of activity, passive activity does not reach normal range; 5. serious: within 4 minutes, function is seriously limited, local function is lost.D. swelling integration method evaluation: 1. normal: 0 minute without swelling; 2. slight: 1 minute mild swelling, centre-height <0.5cm; 3. moderate: moderate swelling in 2 minutes, the about 0.5cm of centre-height; 4. severe: severe swelling in 3 minutes, centre-height is 1～1.5cm approximately; 5. serious: 4 minutes serious swellings, centre-height 1.5cm.
2.2.3 evaluation criteria(1) recovery from illness: pain and swelling disappears completely, without pressure pain point, muscular tone and spasm disappearance, ecchymosis disappearance, local function recovery is normal, and activity reaches normal range, and the rear integration for the treatment of is the above person of front minimizing >95%; (2) effective: pain and swelling disappears substantially, affected part or have slight tenderness, functional activity recovers or approaches normally, and addiction speckle area obviously reduces, and after treatment, integration is treated front minimizing>=70 but <95%; (3) take a turn for the better: pain and swelling obviously alleviates, and affected part still has tenderness, and function before makes moderate progress, ecchymosis area reducing, integration is treated front minimizing>=30% but <70%; (4) invalid: each symptom and sign is before not improved, integration is treated front minimizing <30%.
Note: computing formula for (nimodipine method) is: [integration before (the rear integration of integration one treatment before treatment) ten treatments] x 100%.
2.3 statistical analysisall data are all carried out analyzing and processing by SPSS 15. 0 version software bags on computers, and measurement data data represent with X ± S, between group, relatively use
tcheck, the statistical analysis χ of classified variable data
2check.
p< 0.05 has statistical significance.
four, result;
pain scores comparison before and after 4.1 liang of group treatmentsexperimental group pain, swelling, tenderness and dysfunction scoring and matched group comparison, the equal not statistically significant of difference (
p> 0.05).Table 1.
4.2 liang of group Clinical efficacy comparisonsexperimental group 93 examples, clinical cure 33 examples, effective 54 examples, effective 6 examples, invalid 0 example, total effective rate 100.00%; Matched group 60 examples, clinical cure 4 examples, effective 11 examples, effective 37 examples, invalid 8 examples, total effective rate 86.67%.Two groups of total effective rate comparisons, difference has statistical significance (χ
2=3.14,
p< 0.05).Table 2.
five, conclusion:
Firkin drives pain liniment treatment arthromyodynia and has good expelling wind and removing dampness, the effect of removing obstruction in the collateral to relieve pain.Treat clinically acute soft tissue injury determined curative effect, and safety is good.
Accompanying drawing explanation:
Fig. 1 is visual analogue scales figure.
The specific embodiment:
embodiment 1: raw material: Heiguteng exract 150g, Lysimachia trientaloides Hemsl. 150g, Radix Toddaliae Asiaticae 100g, Radix Psammosilenes 100g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 100g, Radix Cinnamomi Camphorae 100g, Caulis et folium gaultheriae yunnanensis 100g, Blumeae preparatum Tabellae 15g, Fructus Zanthoxyli oil 20g, polyethylene contract the first and second aldehyde 100g, 75% ethanol 30ml
preparation method: by Heiguteng exract, Lysimachia trientaloides Hemsl., Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis seven flavor medicine, add 10 times of amount water boiling and extraction 3 times at every turn, each decoction 1 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.12-1.16 (80 ℃), adds ethanol and makes medicinal liquid contain alcohol amount to reach 75%; Add polyvinyl formal-acetal, after adding 75% soak with ethanol to expand, it is dissolved completely, stir evenly standby; After alcohol deposit fluid is added to Blumeae preparatum Tabellae and Fructus Zanthoxyli oil, stir with substrate, add 75% ethanol and adjust total amount to 1000g, obtain.
embodiment 2: raw material: Heiguteng exract 100g, Lysimachia trientaloides Hemsl. 100g, Radix Toddaliae Asiaticae 70g, Radix Psammosilenes 70g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 70g, Radix Cinnamomi Camphorae 70g, Caulis et folium gaultheriae yunnanensis 70g, Blumeae preparatum Tabellae 5g, Fructus Zanthoxyli oil 10g, polyethylene contract the first and second aldehyde 70g, 75% ethanol 20ml
preparation method: by Heiguteng exract, Lysimachia trientaloides Hemsl., Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis seven flavor medicine, add 10 times of amount water boiling and extraction 3 times, each 1 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.12-1.16 (80 ℃), adds ethanol and makes medicinal liquid contain alcohol amount to reach 75%; Add polyvinyl formal-acetal, after adding 75% soak with ethanol to expand, it is dissolved completely, stir evenly standby; After alcohol deposit fluid is added to Blumeae preparatum Tabellae and Fructus Zanthoxyli oil, stir with substrate, add 75% ethanol and adjust total amount to 800g, obtain.
embodiment 3: raw material: Heiguteng exract 200g, Lysimachia trientaloides Hemsl. 200g, Radix Toddaliae Asiaticae 150g, Radix Psammosilenes 150g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 150g, Radix Cinnamomi Camphorae 150g, Caulis et folium gaultheriae yunnanensis 150g, Blumeae preparatum Tabellae 20g, Fructus Zanthoxyli oil 30g, polyethylene contract the first and second aldehyde 150g, 75% ethanol 50ml
preparation method: by Heiguteng exract, Lysimachia trientaloides Hemsl., Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis seven flavor medicine, add 10 times of amount water boiling and extraction 3 times at every turn, each decoction 1 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.12-1.16 (80 ℃), adds ethanol and makes medicinal liquid contain alcohol amount to reach 75%; Add polyvinyl formal-acetal, after adding 75% soak with ethanol to expand, it is dissolved completely, stir evenly standby; After alcohol deposit fluid is added to Blumeae preparatum Tabellae and Fructus Zanthoxyli oil, stir with substrate, add 75% ethanol and adjust total amount to 1200g, obtain.
Claims (3)
1. a Chinese medicine preparation for the treatment of pain disease or arthromyodynia, is characterized in that: it is to add that by raw material of Chinese medicine Heiguteng exract 100～200g, Lysimachia trientaloides Hemsl. 100～200g, Radix Toddaliae Asiaticae 70～150g, Radix Psammosilenes 70～150g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 70～150g, Radix Cinnamomi Camphorae 70～150g, Caulis et folium gaultheriae yunnanensis 70～150g, Blumeae preparatum Tabellae 5～20g contract first and second aldehyde 70～150g, 75% ethanol 20～50ml of Fructus Zanthoxyli oil 10～30g, polyethylene is prepared from.
2. the Chinese medicine preparation for the treatment of pain disease or arthromyodynia according to claim 1, is characterized in that: it is to add that by raw material of Chinese medicine Heiguteng exract 150g, Lysimachia trientaloides Hemsl. 150g, Radix Toddaliae Asiaticae 100g, Radix Psammosilenes 100g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 100g, Radix Cinnamomi Camphorae 100g, Caulis et folium gaultheriae yunnanensis 100g, Blumeae preparatum Tabellae 15g contract the first and second aldehyde 100g, 75% ethanol 30ml of Fructus Zanthoxyli oil 20g, polyethylene is prepared from.
3. described in claim 1 or 2, treat the preparation method of the Chinese medicine preparation of pain disease or arthromyodynia, it is characterized in that: by Heiguteng exract, Lysimachia trientaloides Hemsl., Radix Toddaliae Asiaticae, Radix Psammosilenes, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Radix Cinnamomi Camphorae, Caulis et folium gaultheriae yunnanensis seven flavor medicine, add 10 times of amount water boiling and extraction 3 times at every turn, each decoction 1 hour, filter, merging filtrate, the thick paste that while being evaporated to 80 ℃, relative density is 1.12-1.16, adds ethanol and makes medicinal liquid contain alcohol amount to reach 75%; After adding polyvinyl formal-acetal, 75% soak with ethanol to expand, it is dissolved completely, stir evenly standby; After alcohol deposit fluid is added to Blumeae preparatum Tabellae and Fructus Zanthoxyli oil, stir with substrate, add after 75% ethanol adjustment, obtain.
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| CN104547155A (en) * | 2014-12-31 | 2015-04-29 | 贵州苗康医药科技有限公司 | Meridian obstruction removing and blood circulation activating pharmaceutical preparation for external use and preparation method thereof |
| CN104666461A (en) * | 2015-02-12 | 2015-06-03 | 贵阳中医学院 | Medicament for treating rheumatoid arthritis and preparation method of medicament |
| CN108310091A (en) * | 2018-04-28 | 2018-07-24 | 吴晓勇 | A kind of externally applied drug and preparation method thereof for treating pain and rheumatism |
| CN108653651A (en) * | 2018-06-14 | 2018-10-16 | 山东融基健康管理股份有限公司 | A kind of pennywort dredging collateral dampness elimination drug moxa stick and its processing technology |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547155A (en) * | 2014-12-31 | 2015-04-29 | 贵州苗康医药科技有限公司 | Meridian obstruction removing and blood circulation activating pharmaceutical preparation for external use and preparation method thereof |
| CN104666461A (en) * | 2015-02-12 | 2015-06-03 | 贵阳中医学院 | Medicament for treating rheumatoid arthritis and preparation method of medicament |
| CN108310091A (en) * | 2018-04-28 | 2018-07-24 | 吴晓勇 | A kind of externally applied drug and preparation method thereof for treating pain and rheumatism |
| CN108653651A (en) * | 2018-06-14 | 2018-10-16 | 山东融基健康管理股份有限公司 | A kind of pennywort dredging collateral dampness elimination drug moxa stick and its processing technology |
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| Publication number | Publication date |
|---|---|
| CN104000920B (en) | 2016-03-09 |
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