CN106727937A - It is a kind of to improve the health care of sleep Chinese medicine composition of state and preparation method thereof - Google Patents
It is a kind of to improve the health care of sleep Chinese medicine composition of state and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/10—Peat; Amber; Turf; Humus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
It is specifically a kind of to improve the health care of sleep Chinese medicine composition of state and preparation method thereof the present invention relates to the field of Chinese medicines.It is characterized in that being made up of the raw material of following portions by weight：6~12 parts of amber, 9~15 parts of mother-of-pearl, 9~15 parts of Os Draconis, 9~15 parts of raw oyster, 20~40 parts of the red sage root.Compared with the existing technology, simple production process, low production cost, implementation are strong, it is easy to large-scale industrial production for the present invention；The Chinese medicine being compounded to form by amber, mother-of-pearl, Os Draconis, raw oyster, red sage root etc. has significant curative effect for improving the health care of sleep state, and for improving the health care of sleep state effect is significant, Small side effects can long-term taking；Dose is small simultaneously, convenient to take, and can preferably ensure medicine stability and effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition for improving the health care of sleep state and its preparation side
Method.
Background technology
Sleep-disorder syndrome is one group drops to the clinical common disease of main performance with sleep quality, with diet because
The factor such as element, environmental factor, disease, pressure is excessive is relevant, is apt to occur in the crowd of all age group.Patient is mainly shown as mistake
Dormancy, sleep paralysis, the symptoms such as preceding illusion, difficulty falling asleep, sleep-walking, sometimes sleeping and sometimes waking, Periodic leg movements are slept, had a strong impact on the normal of patient
Life, influences normal operating efficiency.Sleep-disorder syndrome has that the incidence of disease is high, disease time is long, recurrent exerbation the characteristics of.It is long
The patient that there is sleep-disorder phase easily triggers the complication such as neurological dysfunction, digestive function exception, physical dysfunction, reduces
Immunity of organisms, influences the physical and mental health of patient.Doctor trained in Western medicine is mainly treated using tranquilizing and allaying excitement class medicine, but long-term taking
There is dependence, the danger with habituation, abuse and excess, being excessively used Central nervous has damage, influences therapeutic effect, no
Suggestion long-term taking Western medicine drug.
Modern Chinese medicine thinks that sleep-disorder syndrome is the volt abnormal aggregation of the cause of fire, after effect body Mucosal system, especially
Small intestine and biliary tract mucous membrane, cause organism endocrine exception, disturb stress response system, cause " Neuro-endocrine-immunity " to regulate and control disorderly
Disorderly, one group of metabolic disorder syndrome of sleep center aberrant electrical signals is triggered.
This new knowledge highlights " volt the cause of fire son " and " body Mucosal system ", this be cause sleep-disorder syndrome at the beginning of
Beginning condition and reason.From this understanding, we can just shoot the arrow at the target on sleep-disorder syndrome technology is prevented and treated, science,
Specification, system give more active treatment for sleep-disorder syndrome.
Have confirmed now, brain stem tail end has very important relation with sleep, it is considered to be the place of sleep center.This
The various excitant lesions in position cause hypersomnia, and destructive lesion causes sleep to reduce.It has further been found that in having during sleep
The neurohumoral participation of pivot, stimulates serotoninergic neuron or injection 5-HTP, can produce nonrapid eye movement sleep, and
To Serotonin Antagonist, sleep is produced to reduce.Using norepinephrine antagonistic, then rapid eye movement sleep is reduced, and is given
Norepinephrine excitomotor, rapid eye movement sleep increases.
The content of the invention
The present invention is to overcome the deficiencies in the prior art, there is provided a kind of Chinese medicine composition, and it is used to improve the health care of sleep state effect
Fruit significantly, Small side effects, can long-term taking, and the Chinese medicine composition dose is small, convenient to take, and can preferably protect
Card medicine stability and effect.
To achieve the above object, a kind of Chinese medicine composition for improving the health care of sleep state is designed, it is characterised in that by following weight
The raw material of number is made：6~12 parts of amber, 9~15 parts of mother-of-pearl, 9~15 parts of Os Draconis, 9~15 parts of raw oyster, the red sage root 20~
40 parts.
The amber, mother-of-pearl, Os Draconis, raw oyster and the red sage root are its water extract or extractive with organic solvent.
A kind of preparation method of the Chinese medicine composition for improving the health care of sleep state as claimed in claim 1, it is characterised in that bag
Include following preparation process：
1）Step 1, takes amber, the red sage root of above-mentioned parts by weight, soaks 0.5~1 hour, is then heated to reflux 2~3 times,
1~3 hour every time, volatile oil is collected, volatile oil adds microcrystalline cellulose, be well mixed, obtain volatile oil figuration powder, liquid is while hot
Filtering, filtrate merges, and obtains a filtrate；
2）Step 2, takes mother-of-pearl, Os Draconis, the raw oyster of above-mentioned percentage by weight, then adds water to cook 2 times, first time 0.5
~2 hours, second 1~3 hour, filtration obtained No. two filtrates；
3）Step 3, merges a filtrate and No. two filtrates, with organic solvent filtering and concentrating, organic solvent is reclaimed, 25 DEG C~60
It is condensed into thick paste in the case of DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
Organic solvent in the step 3 is ethanol, organic solvent concentration condition for be concentrated into relative density for 1.08~
1.28, add ethanol to make the alcohol content of organic solvent be 50~70%.
Diluent, lubricant, adhesive, disintegrant, sweetener, stabilizer, anti-is added in the Chinese medicinal composition preparation
One or more mixture in rotten agent etc..
Described Chinese medicinal composition preparation is the one kind in pulvis, tablet, granule, capsule, soft capsule, spray.
Compared with the existing technology, simple production process, low production cost, implementation are strong, it is easy to large-scale industry for the present invention
Metaplasia is produced；The Chinese medicine being compounded to form by amber, mother-of-pearl, Os Draconis, raw oyster, red sage root etc. for improve the health care of sleep state have it is aobvious
The curative effect of work, for improving the health care of sleep state effect is significant, Small side effects can long-term taking；Dose is small simultaneously, convenient to take,
And can preferably ensure medicine stability and effect.
Specific embodiment
The property of medicine and pharmacology of the medicine selected by the present invention are respectively：
（1）Amber, meridian distribution of property and flavor：It is sweet, flat.The thoughts of returning home, liver, small intestine, bladder, lung, the spleen channel；Indication：Calmness, diuresis, promoting blood circulation.
For infantile convulsion, epilepsy, palpitaition, insomnia, difficult urination, odynuria, hematuria, amenorrhoea.
（2）Mother-of-pearl, meridian distribution of property and flavor：It is salty, cold.Return liver, the heart channel of Hang-Shaoyin；Indication：Soothing the liver, checking exuberance of yang, arresting convulsion, hemostasis.For
Dizzy, tinnitus, palpitaition, insomnia, demented, frightened epilepsy is spitted blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia
（3）Os Draconis, meridian distribution of property and flavor：It is sweet, puckery, flat, the thoughts of returning home, liver and kidney channel；Indication：Checking exuberant yang to ease mental strain, for hyperactivity of yang due to yin deficiency,
Irritable, palpitation and insomnia is had a dizzy spell, demented frightened grade disease
（4）Raw oyster, meridian distribution of property and flavor：It is salty, it is slightly cold.Return liver, courage, kidney channel；Indication：Calming the liver, transquilization with heavy material, softening hard masses dissipate
Knot, restrains astringent or styptic treatment for spontaneous sweating.For enriching yin, blood-nourishing, tonifying five zang organs, invigorate blood circulation, fill flesh etc..
（5）The red sage root, meridian distribution of property and flavor：It is bitter, be slightly cold.The thoughts of returning home, Liver Channel；Indication：Promoting blood circulation, it is inducing meastruation to relieve menalgia, clear away heart-fire and remove
It is tired, cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea warp
Close, sore swell and ache curative.
Heretofore described diluent includes but is not limited to lactose, starch, microcrystalline cellulose, mannitol etc.；Described
Lubricant includes but is not limited to magnesium stearate, talcum powder etc.；Described adhesive includes but is not limited to polyethylene Topiramate Los oxazolidinone, hydroxyl
Propyl cellulose etc.；Described disintegrant includes but is not limited to carboxymethylcellulose calcium, acetic acid carboxy starch sodium, PVPP
Deng；Described sweetener includes but is not limited to sucrose, fructose, D-sorbite etc.；Described stabilizer includes but is not limited to carboxylic first
Base sodium cellulosate, cyclodextrin, xanthans etc.；Described preservative includes but is not limited to potassium sorbate, nipagin esters etc..
Heretofore described method for concentration can be using the conventional method such as vacuum concentration or normal temperature be concentrated under reduced pressure.Drying side
Method can be using conventional methods such as spray drying or freeze-dryings.The method that filtrate and residue are separate can using filtering or
The conventional methods such as person's centrifugation.
Embodiment one：
Amber 6g, red sage root 20g are taken first, 0.5 hour is soaked and then is heated to reflux 3 times, 3 hours every time, collect volatilization
Oil, volatile oil adds microcrystalline cellulose, is well mixed, and obtains volatile oil figuration powder, and liquid is filtered while hot, and filtrate merges, and obtains No. one
Filtrate.
Mother-of-pearl 9g, Os Draconis 9g, raw oyster 9g then are weighed, is then added water to cook 2 times, for the first time 0.5 hour, second
Secondary 1.5 hours, filtration obtained No. two filtrates.
Finally a filtrate and No. two filtrates are merged, with organic solvent filtering and concentrating, organic solvent is reclaimed, 25 DEG C~
It is condensed into thick paste in the case of 60 DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
The present embodiment is used to improve the health care of sleep state.Orally, one time 10~20 grams every time（1~3 bag）, daily 1~3 time.
Embodiment two：
Amber 9g, red sage root 30g are taken, 1 hour is soaked and then is heated to reflux 2 times, 1.5 hours every time, collect volatile oil, volatilization
Oil plus microcrystalline cellulose, are well mixed, and obtain volatile oil figuration powder, and liquid is filtered while hot, and filtrate merges, and obtains a filtrate.
Mother-of-pearl 12g, Os Draconis 12g, raw oyster 12g then are weighed, is then added water to cook 2 times, 1 hour for the first time, the
Secondary 2 hours, filtration obtained No. two filtrates.
Finally a filtrate and No. two filtrates are merged, with organic solvent filtering and concentrating, organic solvent is reclaimed, 25 DEG C~
It is condensed into thick paste in the case of 60 DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
The present embodiment is used to improve the health care of sleep state.Orally, one time 10~20 grams every time（1~3 bag）, daily 1~3 time.
Embodiment three：
Amber 12g, red sage root 40g are taken, 1 hour is soaked and then is heated to reflux 3 times, 2 hours every time, collect volatile oil, volatilization
Oil plus microcrystalline cellulose, are well mixed, and obtain volatile oil figuration powder, and liquid is filtered while hot, and filtrate merges, and obtains a filtrate.
Mother-of-pearl 15g, Os Draconis 15g, raw oyster 15g then are weighed, is then added water to cook 2 times, 1 hour for the first time, the
Secondary 3 hours, filtration obtained No. two filtrates.
Finally a filtrate and No. two filtrates are merged, with organic solvent filtering and concentrating, organic solvent is reclaimed, 25 DEG C~
It is condensed into thick paste in the case of 60 DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
The present embodiment is used to improve the health care of sleep state.Orally, one time 10~20 grams every time（1~3 bag）, daily 1~3 time.
Model case：
80 patients for being diagnosed as sleep-disorder person are selected, MethodsThe cases enrolled is divided into treatment group and control group by random digits table, its
Middle treatment group 40, man 17, female 23；18~65 years old age, average 46.4 years old；The course of disease 2 months~3.5 years.Control group 40
Example, man 19, female 21；19~64 years old age, average 48.9 years old；The course of disease 1.5 months~3 years.And two groups of patients the age,
The physical data such as sex, course of disease comparing difference is without significant, P ＞ 0.05, with comparativity.
During treatment, the alone estazolam piece treatment of control group, daily 1~2mg sleeps first 30 minutes orally, is within 14 days 1 treatment
Journey.Take 2 courses for the treatment of.The oral present invention for the treatment of group according to particle obtained in specific embodiment 1, take after mixing it with water by boiling water, one time 10~
20 grams（1~3 bag）, daily 1~3 time, course for the treatment of 7 days.Take 4 courses for the treatment of.
| Group | n | Cure | Take a turn for the better | It is invalid | Total effective rate | Adverse reaction example |
| Control group | 40 | 7（17.5%） | 19（47.5%） | 14（35.0%） | 26（65.0%） | 0 |
| Treatment group | 40 | 21（52.5%） | 15（37.5%） | 4（10.0%） | 36（90.0%） | 20 |
Upper table is the comparitive study after the two groups of patients treatment with sleep-disorder syndrome, wherein the therapeutic evaluation cured
Standard be difficulty falling asleep, sleep terror fright at night, dreaminess, it is shallow sleep easily wake up etc. symptom substantially eliminate, length of one's sleep night reaches more than 5 hours, sleeps
Dormancy quality is good, hale and hearty after waking up；The standard of curative effect evaluation of improvement be difficulty falling asleep, sleep terror fright at night, dreaminess, it is shallow sleep easily wake up etc. symptom it is bright
Aobvious to alleviate, length of one's sleep night reaches more than 3 hours, but occasionally has difficulty falling asleep, dreaming often and waking easily, and spiritedness is tired, mental after waking up
The symptom such as blunt；Invalid the standard of curative effect evaluation is that symptom is same treats preceding thing notable difference.
Statistical procedures are carried out using the statistical softwares of SPSS 15.0, measurement data is checked using t, and enumeration data is used
χ2Inspection, is that difference is statistically significant with P ＜ 0.05.
From upper table, control group total effective rate compares P ﹤ 0.05 with treatment group.
Understand that the present invention can safely and effectively improve the health care of sleep state.
Claims (6)
1. a kind of Chinese medicine composition for improving the health care of sleep state, it is characterised in that be made up of the raw material of following portions by weight：Amber 6~
12 parts, 9~15 parts of mother-of-pearl, 9~15 parts of Os Draconis, 9~15 parts of raw oyster, 20~40 parts of the red sage root.
2. a kind of Chinese medicine composition for improving the health care of sleep state as claimed in claim 1, it is characterised in that：The amber, pearl
Mother, Os Draconis, raw oyster and the red sage root are its water extract or extractive with organic solvent.
3. a kind of preparation method of the as claimed in claim 1 Chinese medicine composition for improving the health care of sleep state, it is characterised in that including
Following preparation process：
1）Step 1, takes amber, the red sage root of above-mentioned parts by weight, soaks 0.5~1 hour, is then heated to reflux 2~3 times,
1~3 hour every time, volatile oil is collected, volatile oil adds microcrystalline cellulose, be well mixed, obtain volatile oil figuration powder, liquid is while hot
Filtering, filtrate merges, and obtains a filtrate；
2）Step 2, takes mother-of-pearl, Os Draconis, the raw oyster of above-mentioned percentage by weight, then adds water to cook 2 times, first time 0.5
~2 hours, second 1~3 hour, filtration obtained No. two filtrates；
3）Step 3, merges a filtrate and No. two filtrates, with organic solvent filtering and concentrating, organic solvent is reclaimed, 25 DEG C~60
It is condensed into thick paste in the case of DEG C, drying under reduced pressure is crushed, and is subsequently adding volatile oil figuration powder and auxiliary material, is mixed, is made
Grain, dries, whole grain, and packaging obtains final product Chinese medicinal composition preparation.
4. a kind of preparation method of the Chinese medicine composition for improving the health care of sleep state as claimed in claim 3, it is characterised in that：It is described
Organic solvent in step 3 is ethanol, and organic solvent concentration condition is 1.08~1.28 to be concentrated into relative density, adds ethanol
The alcohol content for making organic solvent is 50~70%.
5. a kind of preparation method of the Chinese medicine composition for improving the health care of sleep state as claimed in claim 3, it is characterised in that：It is described
One in diluent, lubricant, adhesive, disintegrant, sweetener, stabilizer, preservative etc. is added in Chinese medicinal composition preparation
Plant or more than one mixture.
6. a kind of preparation method of the Chinese medicine composition for treating osteocarcinoma as claimed in claim 3, it is characterised in that：In described
Drug composition preparation is the one kind in pulvis, tablet, granule, capsule, soft capsule, spray.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112617548A (en) * | 2020-12-25 | 2021-04-09 | 海南娜古芳沉香科技有限公司 | Kyara extract for preparing latex pillow for improving sleep, preparation method and latex pillow prepared from Kyara extract |
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| CN101642540A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for tranquilizing and allaying excitement |
| CN102526546A (en) * | 2012-01-04 | 2012-07-04 | 田胜利 | Chinese medicinal composition and preparation and preparation method thereof |
| CN104225501A (en) * | 2014-10-09 | 2014-12-24 | 马俊安 | Traditional Chinese medicine for treating cardiac neurosis and preparation method thereof |
| CN104825800A (en) * | 2015-05-27 | 2015-08-12 | 东阿阿胶股份有限公司 | Medicine for treating insomnia and method for manufacturing medicine |
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2017
- 2017-03-31 CN CN201710206265.0A patent/CN106727937A/en not_active Withdrawn
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|---|---|---|---|---|
| CN101199701A (en) * | 2007-11-17 | 2008-06-18 | 刘占红 | Chinese medicine for treating insomnia and preparing method thereof |
| CN101491625A (en) * | 2009-02-11 | 2009-07-29 | 陆小左 | Sedative anti-insomnia oral medicine |
| CN101642540A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for tranquilizing and allaying excitement |
| CN102526546A (en) * | 2012-01-04 | 2012-07-04 | 田胜利 | Chinese medicinal composition and preparation and preparation method thereof |
| CN104225501A (en) * | 2014-10-09 | 2014-12-24 | 马俊安 | Traditional Chinese medicine for treating cardiac neurosis and preparation method thereof |
| CN104825800A (en) * | 2015-05-27 | 2015-08-12 | 东阿阿胶股份有限公司 | Medicine for treating insomnia and method for manufacturing medicine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112617548A (en) * | 2020-12-25 | 2021-04-09 | 海南娜古芳沉香科技有限公司 | Kyara extract for preparing latex pillow for improving sleep, preparation method and latex pillow prepared from Kyara extract |
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Application publication date: 20170531 |