CN106727840A - 防治咽炎的药物组合物 - Google Patents
防治咽炎的药物组合物 Download PDFInfo
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Abstract
本发明公开了一种防治咽炎的药物组合物及其制备方法,本发明药物组合物是以鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓为原料药,配比而成,可按常规制剂工艺制成各种剂型,防治咽炎疗效显著。
Description
技术领域
本发明属于中药技术领域,尤其涉及一种防治咽炎的药物组合物及其制备方法。
背景技术
慢性咽炎为咽部黏膜、黏膜下及淋巴组织的弥漫性炎症,病理改变主要为咽喉部黏膜充血水肿,淋巴细胞、浆细胞、肥大细胞浸润,结缔组织及淋巴组织尤其是淋巴滤泡增生,腺体肥厚,分泌亢进。咽喉乃肺胃之门户,而慢性咽喉炎大多以咽干咽燥为主症,属中医的热证燥证,治燥必先求阴,肺肾阴虚往往引起咽炎,出现咽部红肿干燥作痛、音哑等证候。慢性咽炎西医认为其病因有急性咽炎反复发作,上呼吸道慢性炎症刺激 (如鼻窦炎、慢性扁桃体炎),烟酒过度、粉尘、有害气体等刺激及喜食刺激性食物,职业因素 (如教师、歌手)等。中医认为有脏腑虚损、耗伤阴分,虚火上炎于咽喉;因风热喉痹反复发作,余邪滞留;粉尘、浊气刺激,嗜好烟酒辛辣,劳伤过度引起。今中医治疗或宗 《丹溪心法》 “阴虚火炎”之说,治以滋阴降火、清肺利咽;或守 《南阳活人书》 “梅核气”痰气互结之论,治以理气化痰、利咽散结,但其中有一部分人治疗效果往往不理想。
鸡蛋参:为桔梗科植物鸡蛋参Codonopsis convolvulacea kurz 的干燥地下块茎。秋季挖取块茎洗净泥土,晒干。【性味】甘、微苦、涩,微凉。【功能与主治】补养气血、健脾、生津清热。用于感冒,咳嗽,扁桃体炎,胸痛,食欲不振,营养不良。【性状】本品呈不规则的卵圆形、圆形,长径2~3cm,短径13~28mm。表面灰褐色、灰白色或淡褐色,具不规则的须根痕。外皮呈片状剥离,外皮脱落后显类白色、淡黄白色或淡褐黄色,皱缩不平,有纵向或横向沟纹,有稍凸起的须根痕。上部有茎痕,近茎痕处有细密的环状纹理。质较坚实,破碎后,断面淡黄白色或粉白色,略显角质状。气微,味甜、微苦。收载于卫生部颁藏药标准(第一册),标准编号:WS3-BC-0051-95。
狼萁草:本品为里白科芒萁属植物铁芒萁Dicranopteris linearis(Burm.f.)Underw.[Polypodium lineare Burm.f.;Gleichenia linearis Clarke]的全草。全年均可采收,洗净,去须根与叶柄,将根茎与叶分开,晒干。【性味】苦;甘;平。【功能主治】止血;接骨;清热利湿;解毒消肿。主血崩;鼻衄;咳血;外伤出血;跌打骨折;热淋涩痛;白带;风疹瘙痒;疮肿;烫伤;痔瘘;蛇虫咬伤;咳嗽。【原植物形态】铁芒萁,大型陆生蕨类植物,植株高60-150cm。蔓生。根茎横走,深棕色,幼时基部被棕色毛,后变光滑;叶轴五至八回两叉分枝,一回叶轴长13-16cm,二回以上的羽轴较短,末回叶轴长3.5-6cm;各回腋芽卵形,密被锈色毛;具苞片,卵形,边缘具三角形裂片;除第一回分叉外,其余各回分叉处两侧均有1对托叶状羽片,斜向上,下部的长12-18cm,宽3.2-4cm,上部的变小,披针形或宽披针形;末回羽片与托叶状羽片相似,长5.5-15cm,宽2.5-4cm,篦齿状羽裂几达羽轴;裂片15-40对,披针形或线状披针形,长10-18mm,宽2-3mm,基部上侧的数对极小,三角形,长4-6mm;中脉下面凸起,侧脉斜展,每组有小脉3条,孢子囊群圆形,细小,1列,着生于基部上侧小脉的弯弓处,由5-7个孢子囊组成。收载于中药大辞典。
万年藓:本品为万年藓科万年藓属植物万年藓Climacium dendroides(Hedw.)Web.et Mohr[Leskea dendroides Hedw.]的植物体。春、夏季采收,洗净,晒干。【性味】 苦;寒。【功能主治】 清热除湿;舒筋活络。主风湿劳伤;筋骨疼痛。【化学成份】 含β-谷甾醇(β-sitosterol),豆甾醇(stigmasterol),麦角甾醇(ergosterol),菜油甾醇(campesterol),环鸦片甾烯醇(cyclolaudenol),31-去甲环鸦片甾烯醇(31-norcyclolaudenol),以及金属元素铁、锰、锌、铜等。【原植物形态】 植物体粗大呈树形,地下茎匍匐横生,具假根及膜质鳞状小叶。地上茎直立,多分枝,高达15-20cm,分枝密布绿色鳞毛。茎上部的叶及分枝基部的叶片呈宽卵状三角形或卵状披针形,基部略下延。中肋单一,达于叶尖前终止,叶片上部细胞狭菱形,叶角部细胞圆形,无色半透明。分枝上部的叶片较小,狭长披针形,叶缘锯齿达于中部。雌雄异株。蒴柄细长,长2-4cm,红色;孢蒴直立,长柱形,多出;蒴盖高圆雌形;蒴帽兜形,包盖全孢蒴。收载于中药大辞典。
刺五加苷E(Eleutheroside E):CAS号96038-87-8,分子式C34H46O18,分子量742.73。【药理作用】抗应激反应;预防前列腺和睾丸萎缩。【成分来源】无梗五加皮Acanthopanax sessiliflorus。
尖叶石松碱(Acrifoline):CAS号664-24-4,分子式C16H23NO2,分子量261.36。【成分来源】小接筋草Huperzia selago [Syn. Lycopodium selago],两年石松Lycopodiumannotinum var. acrifolium。
2个原料药化学结构:
尖叶石松碱(Acrifoline) 刺五加苷E(Eleutheroside E)。
发明内容
本发明的目的是克服背景技术的不足,提供一种有效防治咽炎的药物组合物及其制备方法。
本发明是采用如下技术方案实现的:
制成该防治咽炎的药物组合物的原料药的组成和重量份为:
鸡蛋参5200-5300重量份 狼萁草420-430重量份 刺五加苷E230-260重量份 尖叶石松碱50-60重量份 万年藓700-900重量份。
优选的用于防治咽炎的药物组合物,是由如下重量份的原料药组成:
鸡蛋参5250重量份 狼萁草425重量份 刺五加苷E245重量份 尖叶石松碱55重量份 万年藓800重量份。
一种防治咽炎的药物组合物,其特征在于药物组合物可以采用制剂学的常规方法制备成片剂或胶囊剂或滴丸。
一种防治咽炎的药物组合物,其特征在于药物组合物与化学药或中药组成的防治咽炎药物。
一种防治咽炎的药物组合物的制备方法,其特征在于按如下步骤制备:
原料药的组成和重量份为:鸡蛋参5200-5300重量份 狼萁草420-430重量份 刺五加苷E230-260重量份 尖叶石松碱50-60重量份 万年藓700-900重量份;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
优选的一种防治咽炎的药物组合物的制备方法,其特征在于按如下步骤制备:
原料药的组成和重量份为:鸡蛋参5250重量份 狼萁草425重量份 刺五加苷E245重量份 尖叶石松碱55重量份 万年藓800重量份;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
一种防治咽炎的药物组合物的制备方法,其特征在于药物组合物可以采用制剂学的常规方法制备成片剂或胶囊剂或滴丸。
一种防治咽炎的药物组合物的制备方法,其特征在于药物组合物与化学药或中药组成防治咽炎药物。
药物组合物防治咽炎疗效显著。
具体实施方式
实施例1:防治咽炎的药物组合物及其制备方法
防治咽炎的药物组合物的原料药的组成和重量份为:鸡蛋参5250g 狼萁草425g 刺五加苷E245g 尖叶石松碱55g 万年藓800g;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
实施例2:防治咽炎的药物组合物及其制备方法
防治咽炎的药物组合物的原料药的组成和重量份为:鸡蛋参5200g 狼萁草430g 刺五加苷E230g 尖叶石松碱60g 万年藓700g;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
实施例3:防治咽炎的药物组合物及其制备方法
防治咽炎的药物组合物的原料药的组成和重量份为:鸡蛋参5300g 狼萁草420g 刺五加苷E260g 尖叶石松碱50g 万年藓900g;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
实施例4:片剂的制备
取实施例1药物组合物198g,加入淀粉235g,混匀,制粒,干燥,加微晶纤维素113g,硬脂酸镁8g,混匀,压制成1400片, 即得药物组合物片剂。
实施例5:胶囊的制备
取实施例2药物组合物315g,加入淀粉476g,混匀,制粒,干燥,整粒,加入适量硬脂酸镁,混匀,装胶囊2300粒,即得药物组合物胶囊。
实施例6:滴丸的制备
称取聚乙二醇 6000 410g水浴(80℃)加热煮熔,加入实施例3药物组合物21.1g,充分搅拌均匀,以液体石蜡为冷却剂,置玻璃管(4*80cm)中,冷却温度为3℃,滴口内外径为7.0/2.0(mm/mm),滴口距液面为2.6cm,滴速以每分56滴为最佳条件,用棉布吸干滴丸表面的冷凝剂,即得药物组合物滴丸。
实施例7:防治咽炎的药物组合物
防治咽炎的药物组合物的原料药的组成和重量份为:
狼萁草480重量份 尖叶石松碱65重量份 万年藓860重量份。
实施例8:防治咽炎的药物组合物
防治咽炎的药物组合物的原料药的组成和重量份为:
刺五加苷E240重量份 尖叶石松碱70重量份 万年藓950重量份。
实施例9:防治咽炎的药物组合物
防治咽炎的药物组合物的原料药的组成和重量份为:
刺五加苷E270重量份 尖叶石松碱50重量份 万年藓750重量份。
实验例1:防治咽炎的试验研究
1 资料和方法
1.1 一般资料
15例均为门诊确诊患者,其中男性患者8例,女性患者7例;年龄20~50岁,平均35岁;病程1~15年,平均病程5年。
1.2 诊断标准
参照《中医病证诊断疗效标准》,主诉以咽部不适,或痒,或痛,或干燥为主症。咽部检查:咽部充血呈暗红色,咽黏膜增生肥厚或干燥变薄,咽后壁滤泡增生。
1.3 治疗方法
应用自制药物组合物(实施例1药物组合物),处方如下:药物组合物5g,随证加减:若声音嘶哑者加木蝴蝶10 g;干咳少痰、手足心热者加知母10 g;病久气血凝结者加桃仁10 g;心烦不寐者加夜交藤20 g;胸胁胀闷者加郁金12 g。中药每服煎煮两次,分成三份,早、中、晚三次饭后口服。10剂为1个疗程。
1.4 疗效标准
参照《耳鼻咽喉科疾病诊断疗效评定依据及有关解剖生理数据》制定,痊愈:症状完全消失,咽部检查咽充血消退,色泽光滑,无分泌物,滤泡基本消退;好转:症状基本缓解,咽部检查咽充血基本消退,滤泡较前消退;无效:症状与体征同治疗前。总有效率=(痊愈+好转)/总例数×100%。
2 结果
2.1 治疗结果及疗程
15例经上述治疗后,共痊愈10例,好转4例,无效1例,总有效率为93.33%。所有患者在治疗期间未出现不良反应。治疗周期,10d有8例,11~20d有4例,21~30 d有2例,30 d以上有1例,平均为1.6个疗程。
2.2 病案例举
病例1:患者,男,42岁,教师,2011 年 2月就诊,自述有吸烟史10年,平素偶有咳嗽,但不严重,2年前因感冒咳嗽后,逐渐自觉咽喉后壁有物附着,咳之不出、咽之不下、咽干而痒,手足心热,时常咳声阵阵,夜间尤甚,曾到多家医院就诊,时好时发,疗效不著,做钡餐透视,颈突拍片未见异常,后来我院诊治,症状:胸闷,咽干且痒,烦躁,手足心热。咽部检查:咽喉部黏膜弥漫性充血,色暗红,咽后壁有多数绿豆样大小颗粒突起的淋巴滤泡,舌红脉弦细,临床诊断为慢性咽炎,中医辨证属阴虚火旺、虚火上炎,治以滋阴降火、清热解毒、开胸利咽,给予药物组合物(实施例1药物组合物)加减,10 d后,自觉症状明显减轻,咽后壁附着物消失,检查咽喉部充血肿胀消退,突起颗粒缩小,再服药10 d,各项症状消失,为预防复发,嘱其续服前方10 d,以巩固疗效,随访2年未复发。
病例2:患者,女,37岁,2011年3月就诊。自诉因平常夫妻感情不和,常与丈夫发生口角,致精神抑郁,胸闷不适,3年前逐渐自觉咽喉部如有物梗阻,吐之不出,咽之不下,且双乳胀痛,经前尤甚,情绪抑郁,善太息。在当地医院经多次治疗,疗效不显。经介绍来我院诊治,主诉:胸闷、胸肋胀满、口苦、咽干、烦躁、乳房胀痛。咽部检查:咽喉部色暗红,肿胀明显,附有增生的淋巴滤泡,双侧乳腺增生,多发包块,边缘光滑,舌质红无苔、脉弦细。临床诊断为慢性咽炎,中医辨证为“梅核气”(肝郁气滞型),治以疏肝解郁、滋阴降火为主,给予药物组合物(实施例1药物组合物)加减,服上10剂后,自感咽喉中梗阻物消失,胸肋胀满亦减,乳房胀痛亦减轻。体格检查:咽喉壁肿胀消退、淋巴滤泡缩小、舌质红润、脉弦细,乳腺肿块缩小。上方再服10剂巩固,自诉乳房胀痛明显缓解,检查亦未扪及增生的硬结。嘱其保持心态平稳,避免辛辣刺激之品,于每次经前一周可以口服逍遥丸疏肝理气,后随访2年,一切正常。
Claims (8)
1.一种防治咽炎的药物组合物,其特征在于制成该药物组合物的原料药的组成和重量份为:
鸡蛋参5200-5300重量份 狼萁草420-430重量份 刺五加苷E230-260重量份 尖叶石松碱50-60重量份 万年藓700-900重量份。
2.根据权利要求1所述一种防治咽炎的药物组合物,其特征在于制成该药物组合物的原料药的组成和重量份为:
鸡蛋参5250重量份 狼萁草425重量份 刺五加苷E245重量份 尖叶石松碱55重量份 万年藓800重量份。
3.根据权利要求1所述一种防治咽炎的药物组合物,其特征在于药物组合物可以采用制剂学的常规方法制备成片剂或胶囊剂或滴丸。
4.根据权利要求1所述一种防治咽炎的药物组合物,其特征在于药物组合物与化学药或中药组成的防治咽炎药物。
5.一种防治咽炎的药物组合物的制备方法,其特征在于按如下步骤制备:
原料药的组成和重量份为:鸡蛋参5200-5300重量份 狼萁草420-430重量份 刺五加苷E230-260重量份 尖叶石松碱50-60重量份 万年藓700-900重量份;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
6.根据权利要求5所述一种防治咽炎的药物组合物的制备方法,其特征在于按如下步骤制备:
原料药的组成和重量份为:鸡蛋参5250重量份 狼萁草425重量份 刺五加苷E245重量份 尖叶石松碱55重量份 万年藓800重量份;
制备方法:
(1)按原料药配比取鸡蛋参、狼萁草、刺五加苷E、尖叶石松碱、万年藓,混匀,用重量百分比浓度23%乙醇作为溶剂,38℃温浸提取,提取次数为7次,每次提取时间为47小时,每次溶剂用量为原料药总重量的65倍,滤过,得药渣A和提取液A,提取液A回收乙醇,浓缩至相对密度1.12,滤过,药液通过LKS02大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度14.5%乙醇溶液洗脱LKS02大孔吸附树脂柱,收集重量百分比浓度14.5%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物A;
(2)取步骤(1)药渣A,用重量百分比浓度58%乙醇作为溶剂,加热回流提取16次,每次提取时间为0.3小时,每次溶剂用量为药渣A重量的42倍,滤过,得药渣B和提取液B,提取液B回收乙醇,浓缩至相对密度1.07,滤过,药液通过ADS-8大孔吸附树脂柱,先用水洗脱,再用重量百分比浓度38%乙醇溶液洗脱ADS-8大孔吸附树脂柱,收集重量百分比浓度38%乙醇洗脱液,回收乙醇,浓缩干燥,即得提取物B;
(3)将提取物A和提取物B混匀,即得药物组合物。
7.根据权利要求5所述一种防治咽炎的药物组合物的制备方法,其特征在于药物组合物可以采用制剂学的常规方法制备成片剂或胶囊剂或滴丸。
8.根据权利要求5所述一种防治咽炎的药物组合物的制备方法,其特征在于药物组合物与化学药或中药组成防治咽炎药物。
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